ライフサイエンスコーパス: protein methyltransferase

1 We demonstrate that this protein is a protein methyltransferase.

2 also selective toward other AdoMet-dependent protein methyltransferases.

3 the physiological and pathological roles of protein methyltransferases.

4 can be successfully applied to Rossmann-fold protein methyltransferases.

5 probe to study the activities of endogenous protein methyltransferases.

6 ly been used to label substrates of specific protein methyltransferases.

7 m by which p53 represses gene expression via protein methyltransferases.

8 s involved in regulating this novel class of protein methyltransferases.

9 ts homologues contain motifs conserved among protein methyltransferases.

10 oteins, and now designate it Hpm1 (Histidine protein methyltransferase 1).

11 ut similar amounts of ADMA-producing enzyme, protein methyltransferase-1) in the human failing myocar

12 ent in Drosophila melanogaster: the arginine protein methyltransferase 5 (dPRMT5/Csul/Dart5) and its

13 s neural crest gene expression; however, the protein methyltransferases active in neural crest precur

14 We show that the protein methyltransferase activity of the human Skb1 hom

15 activators, including CARM1 and its specific protein methyltransferase activity, in transcriptional a

16 s and nuclei, as well as stimulation of Skb1 protein methyltransferase activity.

17 aevis PRMT5 catalytic domain has appreciable protein methyltransferase activity.

18 mutations in pcm (encoding the L-isoaspartyl protein methyltransferase) and surE led to the finding t

19 Protein methyltransferases are emerging as promising dru

20 roles of SETD7 in cells and further validate protein methyltransferases as a druggable target class.

21 will also be important to isolate additional protein methyltransferases by molecular cloning and to c

22 paper, we identify a class I, non-SET domain protein methyltransferase, calmodulin-lysine N-methyltra

23 ngle gene product can produce a bifunctional protein methyltransferase capable of catalyzing both (al

24 ses of coactivators: a p160 coactivator, the protein methyltransferase CARM1, and any of the three pr

25 tone acetyltransferases p300 and CBP and the protein methyltransferase CARM1.

26 n component, (b) CH3-H4pteridine:cob(I)amide-protein methyltransferase, catalyzed by the intact gamma

27 siae YBR261C/TAE1 gene encodes an N-terminal protein methyltransferase catalyzing the modification of

28 y of the system to stimuli is modulated by a protein methyltransferase (CheR) and a protein methylest

29 (p/CAF), as well as the recently identified protein methyltransferase, coactivator-associated argini

30 ore, we provided evidence that inhibition of protein methyltransferases, especially arginine methyltr

31 These results identify NSD3 as the first protein methyltransferase essential for neural crest gen

32 ProSeAM can be processed by multiple protein methyltransferases for substrate labeling.

33 amily and facilitate the characterization of protein methyltransferase function in vivo when combined

34 esize that it may also serve as a peptide or protein methyltransferase in eukaryotes.

35 apparently a consequence of a monofunctional protein methyltransferase incapable of methylating Lys-1

36 for this conserved protein and suggests that protein methyltransferases may have a role in cellular s

37 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase (MeTr) from Clostridium thermo

38 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase (MeTr) from Clostridium thermo

39 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase (MeTr) from Clostridium thermo

40 ffering only in expression of the DNA repair protein methyltransferase (MGMT), a TMZ-sensitivity dete

41 a member, by sequence homology, of a nuclear protein-methyltransferase (MTase) superfamily involved i

42 he enzymes catalysing methylation reactions, protein methyltransferases (MTases), generally use S-ade

43 tides are first demethylated by a KDM, and a protein methyltransferase (PMT) is added to methylate th

44 Protein methyltransferase (PMT)-mediated posttranslation

45 t-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylas

46 Protein methyltransferases (PMTs) are a promising target

47 The human protein methyltransferases (PMTs) constitute a large enz

48 Protein methyltransferases (PMTs) have emerged as import

49 Protein methyltransferases (PMTs) play critical roles in

50 ng physiological and pathogenic functions of protein methyltransferases (PMTs) relies on knowing thei

51 Mounting evidence suggests that protein methyltransferases (PMTs), which catalyze methyl

52 ations is protein methylation carried out by protein methyltransferases (PMTs).

53 The distinct transition states between protein methyltransferases present the opportunity to de

54 ell, Yamagata et al. identify a role for the protein methyltransferase, PRMT1, in Akt-dependent regul

55 ) analogues that are targeted toward a yeast protein methyltransferase RMT1.

56 The protein methyltransferase Set7/9 was recently shown to r

57 encodes ten predicted SET domain-containing protein methyltransferases, six of which have been shown

58 genetic studies suggested that a presumptive protein methyltransferase, Skb1, functions as a positive

59 essor gene and a member of a nuclear histone/protein methyltransferase superfamily.

60 ach, we identified Skb1p, a highly conserved protein methyltransferase that has been implicated previ

61 ed arginine methyltransferase 1 (CARM1) is a protein methyltransferase that negatively regulates syna

62 sferase 1 (PRMT1), another arginine-specific protein methyltransferase that shares a region of high h

63 bed in this paper, is similar to a family of protein methyltransferases that modify RNA-binding prote

64 G9a and GLP are conserved protein methyltransferases that play key roles during ma