ライフサイエンスコーパス: protein phosphatase

1 dly than controls, but not when treated with protein phosphatase.

2 in reduces ERK activity via recruitment of a protein phosphatase.

3 tiate signal transduction inhibiting type 2C protein phosphatases.

4 d analyze the development of drugs targeting protein phosphatases.

5 TPase activation by inhibiting PP2C.D family protein phosphatases.

6 trin homology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) as a regulatory phosphata

7 trin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a member of the serine

8 disrupt protein-protein interactions between protein phosphatase 1 (PP1) and its regulator CPI-17, re

9 atase drives this reversal in budding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (

10 d amino acid within the domain important for protein phosphatase 1 (PP1) binding.

11 We also show that host cell protein phosphatase 1 (PP1) controls VP30 dephosphorylat

12 The serine-threonine protein phosphatase 1 (PP1) deactivates this pathway whe

13 The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of

14 acid, implicating PDGF-induced activation of protein phosphatase 1 (PP1) in CRMP2 regulation.

15 Here we show in vitro and in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosph

16 However, pretreatment of GCs with the protein phosphatase 1 (PP1) inhibitor tautomycin increas

17 regulatory subunit 1A (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor; however, its role

18 In particular, protein phosphatase 1 (PP1) is recruited to a DSB-mimick

19 ly, pharmacological or genetic inhibition of protein phosphatase 1 (PP1) prevented HTTex1 aggregation

20 We show that PKA directly phosphorylates the protein phosphatase 1 (PP1) regulatory subunit myosin ph

21 IF2alpha phosphatases comprising a catalytic protein phosphatase 1 (PP1) subunit in complex with a PP

22 Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regul

23 he mitotic chromosome periphery and recruits protein phosphatase 1 (PP1) to chromatin at anaphase ons

24 tes with the broadly acting serine/threonine protein phosphatase 1 (PP1) to dephosphorylate eIF2alpha

25 The Ska1 C-terminal domain (CTD) recruits protein phosphatase 1 (PP1) to kinetochores to promote t

26 Here, we show that Ska complex recruits protein phosphatase 1 (PP1) to kinetochores.

27 kinase activity of the IGF-1R by activating protein phosphatase 1 (PP1) to promote dephosphorylation

28 We also demonstrated that functional CK2 and protein phosphatase 1 (PP1) were selectively tethered to

29 ew study, we investigated the interaction of protein phosphatase 1 (PP1) with the SR protein splicing

30 /2 as a positive regulator, whereas purified protein phosphatase 1 (PP1), dephosphorylated Thr-450 in

31 this study we show that Gwl associates with protein phosphatase 1 (PP1), particularly PP1gamma, whic

32 R cytoplasmic domain (cd) and the associated protein phosphatase 1 (PP1), requiring NMDARcd movement,

33 gulation, pSer-68-PLM is dephosphorylated by protein phosphatase 1 (PP1).

34 ed levels of GADD34, a regulatory subunit of protein phosphatase 1 (PP1).

35 d calcineurin (CaN)-deactivated inhibitor of protein phosphatase 1 (PP1).

36 lated by the broadly acting serine/threonine protein phosphatase 1 (PP1).

37 (TTN) is highly selective for a single PPP, protein phosphatase 1 (PP1/PPP1C).

38 rate specificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dictated by PP1c-interac

39 n MEL-28/ELYS docks the catalytic subunit of protein phosphatase 1 (PP1c) to direct kinetochore disas

40 and cardiomyocytes, related to inhibition of protein phosphatase 1 activity.

41 Pi04314 interacts with three host protein phosphatase 1 catalytic (PP1c) isoforms, causing

42 oduct of which recruits the alpha-isoform of protein phosphatase 1 catalytic subunit (PP1alpha) and e

43 Exposure of these CCM cells to protein phosphatase 1 caused a transitory increase in Ca

44 Finally, we show that protein phosphatase 1 counteracts Aurora B activity to e

45 electively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

46 MBS85), paxillin and CPI-17 (PKC-potentiated protein phosphatase 1 inhibitor protein of 17 kDa) phosp

47 etermined the expression and localization of protein phosphatase 1 regulatory inhibitor subunit 11 (P

48 Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is

49 Protein phosphatase 1 regulatory subunit 1B(+) BLA pyram

50 ction closest to the mapped region, PPP1R3B (protein phosphatase 1 regulatory subunit 3B), encodes a

51 nophilin (abbreviated spn; gene name Ppp1r9b protein phosphatase 1 regulatory subunit 9b) and the cla

52 Therefore the role of the protein phosphatase 1 should be considered as an additio

53 RK-1/2 via increased DUSP1 (dual-specificity protein phosphatase 1) expression.

54 se 5 (Cdk5), glycogen synthase kinase 3beta, protein phosphatase 1, or protein phosphatase 2A, but re

55 131, which affects the expression of ORMDL3, protein phosphatase 1, regulatory inhibitor subunit 1B (

56 between TIBC and a variant near the gene for protein phosphatase 1, regulatory subunit 3B (PPP1R3B; r

57 s dephosphorylation by kinetochore-localized protein phosphatase 1, which allows Cdc20 to activate th

58 neurons, NMDA receptor stimulation induces a protein phosphatase 1-dependent dephosphorylation of CDK

59 rora B, Mps1, and Plx1) and is suppressed by protein phosphatase 1.

60 ethod was expanded to detect the activity of protein phosphatase 1.

61 T840 dephosphorylation could be blocked by a protein phosphatase 1/2A (PP1/PP2A) inhibitor and was pa

62 brain slices of WKY rats pretreated with the protein phosphatase 1/2A, calcineurin, or casein kinase-

63 ion of the PH domain and leucine-rich repeat protein phosphatases 1 (PHLPP1), a phosphatase of Akt.

64 Inhibition of protein phosphatases 1 and 2A and activation of PKC incr

65 yrosine phosphatases or the serine/threonine protein phosphatases 1 and 2A decreased Ih at maximal ac

66 Inhibition of serine/threonine protein phosphatases 1 and 2A decreased maximal Ih and H

67 ttributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transm

68 sphorylation-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phospha

69 s mediated at least in part by inhibition of protein phosphatase-1 (PP1c) via persulfidation at Cys-1

70 The serine/threonine protein phosphatase-1 catalytic subunit (PP-1c) is a maj

71 in phosphatase (MP) holoenzyme consisting of protein phosphatase-1 catalytic subunit (PP1c) and MP ta

72 Increased protein phosphatase-1 in heart failure (HF) induces mole

73 Inhibiting protein phosphatase-1 through the overexpression of a co

74 c were determined to be potent inhibitors of protein phosphatase-1 with similar activity.

75 at involves the phosphatases calcineurin and protein phosphatase-1, as well the serine/threonine kina

76 We show that AR recruits protein phosphatase 1alpha (PP1alpha), resulting in P-TE

77 t mortalin can regulate MEK/ERK activity via protein phosphatase 1alpha (PP1alpha).

78 Protein phosphatase-1alpha (PP1alpha) was identified as

79 Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated

80 opsis (Arabidopsis thaliana) Shewanella-like protein phosphatase 2 (AtSLP2) is a bona fide Ser/Thr pr

81 The protein phosphatase 2 (PP2A) holoenzyme consists of a ca

82 how the potential of LB100, a small-molecule protein phosphatase 2 A (PP2A) inhibitor, as a monothera

83 rylating Tau at AD specific phospho-sites is protein phosphatase 2 A (PP2A).

84 2A (PP2A) regulatory subunit B family genes protein phosphatase 2, regulatory Subunit B', beta (PPP2

85 regulatory Subunit B', gamma (PPP2R5C); and protein phosphatase 2, regulatory Subunit B', delta (PPP

86 se 2, regulatory Subunit B', beta (PPP2R5B); protein phosphatase 2, regulatory Subunit B', gamma (PPP

87 BR1) interacted with the B'' subunit of rice protein phosphatase 2A (OsPP2A B'') and underwent revers

88 d sphingolipids are required to activate the protein phosphatase 2A (PP2A(Cdc55)) to attenuate Swe1 p

89 Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aalpha scaffold subunit ge

90 dding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) activities have each been

91 Protein phosphatase 2A (PP2A) activity can be enhanced p

92 etaphase entry or progression by suppressing protein phosphatase 2A (PP2A) activity.

93 Here, we show that protein phosphatase 2A (PP2A) acts as opsin phosphatase

94 ells was associated with a lower activity of protein phosphatase 2A (PP2A) and augmented activity of

95 /ERK and its subsequent dephosphorylation by protein phosphatase 2A (PP2A) and inhibition of focal ad

96 Non-canonically activated ERK activates protein phosphatase 2A (PP2A) and lengthens cell cycle d

97 dynamics of PIN proteins are affected by the protein phosphatase 2A (PP2A) and the PINOID kinase, whi

98 Here we show that cytoplasm-localized protein phosphatase 2A (PP2A) B' regulatory subunits int

99 Protein phosphatase 2A (PP2A) became more eNOS-associate

100 Protein phosphatase 2A (PP2A) complexes counteract many

101 un with chromatin is positively regulated by protein phosphatase 2A (PP2A) complexes targeted to c-Ju

102 kinase 1 (RACK1) as the regulatory subunit, protein phosphatase 2A (PP2A) dephosphorylates threonine

103 Observed deficits in protein phosphatase 2A (PP2A) function in a variety of h

104 ly conserved serine (Ser)/threonine-specific protein phosphatase 2A (PP2A) functions as a heterotrime

105 ivation chaperones control the biogenesis of protein phosphatase 2A (PP2A) holoenzymes that contain a

106 s, and that serine 59 is dephosphorylated by protein phosphatase 2A (PP2A) in mitosis.

107 Here, we show that overexpression of the protein phosphatase 2A (PP2A) inhibitor protein PME-1 dr

108 Protein phosphatase 2A (PP2A) is a highly conserved and

109 Protein phosphatase 2A (PP2A) is a member of the intrace

110 Herein, cellular serine/threonine protein phosphatase 2A (PP2A) is identified as a functio

111 Protein phosphatase 2A (PP2A) negatively regulates tumor

112 We found that deletion of protein phosphatase 2A (PP2A) or of protein phosphatase

113 Protein phosphatase 2A (PP2A) participates in multiple m

114 Protein phosphatase 2A (PP2A) plays important roles in c

115 Protein phosphatase 2A (PP2A) presents unique opportunit

116 de novo mutations revealed four mutations in protein phosphatase 2A (PP2A) regulatory subunit B famil

117 orylation and activation of serine/threonine protein phosphatase 2A (PP2A) regulatory subunit, B56bet

118 The protein phosphatase 2A (PP2A) subfamily of phosphatases,

119 lternative splice mutation in the regulatory protein phosphatase 2A (PP2A) subunit PPP2R2A.

120 in 2 subunits of serine/threonine (Ser/Thr) protein phosphatase 2A (PP2A) were identified in 16 indi

121 ated that activation of the tumor suppressor protein phosphatase 2A (PP2A), a negative regulator of m

122 f key regulators of hepatic gluconeogenesis, protein phosphatase 2A (PP2A), AMP-activated protein kin

123 The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (

124 xes that appear to act through regulation of protein phosphatase 2A (PP2A), but their functions in ma

125 Mechanistically, PI3Kgamma sequesters protein phosphatase 2A (PP2A), disrupting ERK-PP2A inter

126 Phosphatases, such as protein phosphatase 2A (PP2A), interestingly, also are c

127 PyST enhanced YAP association with protein phosphatase 2A (PP2A), leading to decreased YAP

128 SH-BC-893 activated protein phosphatase 2A (PP2A), leading to mislocalizatio

129 Binding of YAP to MT brings it together with protein phosphatase 2A (PP2A), leading to the dephosphor

130 Exposure of BL41-3 cells to an inhibitor of protein phosphatase 2A (PP2A), okadaic acid, resulted in

131 his study, we show that the tumor suppressor protein phosphatase 2A (PP2A), one of the major Ser/Thr

132 The phosphorylation of Tau is regulated by protein phosphatase 2A (PP2A), which in turn is modulate

133 Protein phosphatase 2A (PP2A), YAP, Src family tyrosine

134 ll death in a number of mammalian cells in a protein phosphatase 2A (PP2A)-dependent manner.

135 Here we report that MEF2 induces a Protein phosphatase 2A (PP2A)-mediated dephosphorylation

136 d Bub1 kinase and the Sgo1-bound phosphatase protein phosphatase 2A (PP2A)-Rts1 underlie a tension-de

137 t translational modification and activity of protein phosphatase 2A (PP2A).

138 activities of a group of phosphatases called protein phosphatase 2A (PP2A).

139 reduced Janus kinase-mediated inhibition of protein phosphatase 2a (PP2A).

140 ifications, make it a nanomolar inhibitor of protein phosphatase 2A (PP2A).

141 that interact with the catalytic subunit of protein phosphatase 2A (PP2Ac).

142 (ATM) activation by a mechanism dependent on protein phosphatase 2A activity.

143 In vitro, FAM13A interacts with protein phosphatase 2A and recruits protein phosphatase

144 yeasts to be mediated by recruitment of the protein phosphatase 2A B' (PP2A B').

145 t, Cdr2-T166 phosphorylation is regulated by protein phosphatase 2A but not by the Sds23-PP6 pathway.

146 Here we discovered that the protein phosphatase 2A heterotrimer, PP2A(Ppp2r2d), regu

147 this is mediated by metabolic activation of protein phosphatase 2A in complex with the B55beta targe

148 Protein phosphatase 2A mediated the reduction in NF-kapp

149 have previously shown that the Dictyostelium protein phosphatase 2A regulatory subunit B56, encoded b

150 cts with protein phosphatase 2A and recruits protein phosphatase 2A with glycogen synthase kinase 3be

151 (armadillo/huntingtin, elongation factor 3, protein phosphatase 2A, and the yeast kinase TOR1) or BE

152 named after Huntingtin, elongation factor 3, protein phosphatase 2A, and yeast kinase TOR1) repeat.

153 hase kinase 3beta, protein phosphatase 1, or protein phosphatase 2A, but reduces p35 subunit of Cdk5.

154 ties of tau kinases and phosphatases such as protein phosphatase 2A, irrespective of fisetin treatmen

155 more, we show that a novel host cell factor, protein phosphatase 2A, is involved in NS2 dephosphoryla

156 f six (A-F) Huntingtin, elongation factor 3, protein phosphatase 2A, target of rapamycin (HEAT) repea

157 Inhibition of protein phosphatase 2A, which also contributes to sustai

158 stead, both agents increased the activity of protein phosphatase 2A, which inactivates protein kinase

159 We identified PROTEIN PHOSPHATASE 2A-3 (PP2A-3), a catalytic subunit o

160 ase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A-A), a key factor that fac

161 are mediated by protein kinase C but not by protein phosphatase 2A.

162 ed for NF-kappaB activation by regulation of protein phosphatase 2A.

163 YAP, small t antigen brings it together with protein phosphatase 2A.

164 up a CAR surface, allowing interaction with protein phosphatase 2A.

165 Protein phosphatase-2A (PP2A) is an abundant serine/thre

166 in protein kinase A dependent activation of protein phosphatase-2A (PP2A).

167 ion were reduced in TRAIL(-/-) mice, whereas protein phosphatase 2Ac levels were increased compared w

168 to and deactivates the catalytic subunit of protein phosphatase 2Ac, resulting in increased nuclear

169 kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2B (calcineurin) to modulate second

170 in the non-miR-185 targets serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform,

171 ibitors of NMDA-type glutamate receptors and protein phosphatase 2B prevented depolarization-induced

172 Statin-activated PXR scaffolds the protein phosphatase 2C (PP2C) and SGK2 to stimulate PP2C

173 itory and RelA phosphatase activities of the protein phosphatase 2C (PP2C) phosphatase family member,

174 , together with a plant-specific subclade of protein phosphatase 2C (PP2C), form functional holorecep

175 receptor (RCAR)/PYR1/PYL] and an associated protein phosphatase 2C (PP2C).

176 and Brassica napus gene paralogues encoding protein phosphatase 2C (PP2C, group A), which is known t

177 The protein phosphatase 2C HAB1, a critical component in ABA

178 ors, which alleviates negative regulation by protein phosphatases 2C (PP2Cs) of the protein kinase OP

179 eventing its inhibitory dephosphorylation by protein phosphatase-2C rather than inducing de novo kina

180 Interestingly, protein phosphatase 2Cs prevent non-specific Ca(2+)-sign

181 e the cellular phosphatase catalytic subunit protein phosphatase 4C (PP4C) in the regulation of this

182 Protein phosphatase 5 (PP5) is auto-inhibited by intramo

183 Here we show that protein phosphatase 5 (PP5) reciprocally regulates each

184 The serine/threonine phosphatase protein phosphatase 5 (PP5) regulates hormone- and stres

185 al differentially expressed proteins, namely protein phosphatase 5 (PP5), formyl peptide receptor 2,

186 y, when paired with the deactivation of a GR-protein phosphatase 5 pathway, resulted in sustained GR

187 In addition, protein phosphatase-5 (PP5) increased its association wi

188 etion of protein phosphatase 2A (PP2A) or of protein phosphatase 6 (PP6) protects cells from the redu

189 -A, DNA-PK catalytic subunit (DNA-PKcs), and protein phosphatase 6 (PP6), which interacts with DNA-PK

190 We identify the catalytic subunit of protein phosphatase 6 (PP6c) as the critical substrate w

191 Furthermore, protein phosphatase 6 (ppp6c), a negative regulator that

192 and this phosphosite is dephosphorylated by protein phosphatase 6.

193 Two of them belong to clade A of type 2C protein phosphatases: ABA-HYPERSENSITIVE GERMINATION 1 (

194 hree Clade E Growth-Regulating (EGR) Type 2C protein phosphatases act as negative growth regulators t

195 N function in ICL repair is dependent on its protein phosphatase activity and ability to be SUMOylate

196 of phosphate and tensin homolog through its protein phosphatase activity and that the increase in IN

197 Here we report inherited dysregulation of protein phosphatase activity as a cause of intellectual

198 d concomitant with a significant increase in protein phosphatase activity for two colon cancer cell l

199 iety of PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with

200 A Deltacdc55 mutation affecting Cdc55-PP2A protein phosphatase activity prevented Orm dephosphoryla

201 of 709 genes, among which genes involved in protein phosphatase activity were overrepresented, sugge

202 transcriptional coactivators with intrinsic protein phosphatase activity.

203 tein kinase activity must be counteracted by protein phosphatase activity.

204 ence that DOG1 can interact with the type 2C protein phosphatases AHG1 and AHG3 and that this represe

205 d erbB4 and decreased receptor-type tyrosine-protein phosphatase-alpha (RPTPalpha) and dysbindin-1, e

206 n inducible model of loss of function of the protein phosphatase and tensin homologue (PTEN), a phosp

207 lated Pah1 was a substrate for the Nem1-Spo7 protein phosphatase and was degraded by the 20S proteaso

208 annels, membrane receptors, protein kinases, protein phosphatases and proteins of unknown function.

209 components PYL/RCAR ABA receptors, PP2C-type protein phosphatases, and protein kinases.

210 ely, suppressor of cytokine signaling (SOCS) proteins, phosphatases, and protein inhibitor of activat

211 nvolvement of specific calcineurin isoforms, protein phosphatase at 14D (Pp2B-14D)/calcineurin A at 1

212 Here we identify the Ca(2+)-dependent protein phosphatase calcineurin (CaN) as a key regulator

213 strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated ex

214 gically blocked by antagonists of either the protein phosphatase calcineurin or neurotensin receptors

215 av activates the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin, which is essential for

216 activation of the type 2 NT receptor and the protein phosphatase calcineurin.

217 n increase in the expression/activity of the protein phosphatase calcineurin.

218 Application of AID to the calcium-regulated protein phosphatase, calcineurin, revealed functions in

219 genetics to show that the calcium-regulated protein phosphatase, calcinuerin, regulates invasion in

220 nhibition of activities of PP2A or PP2A-like protein phosphatases can increase transcript levels of s

221 kinases phosphorylate client proteins, while protein phosphatases catalyze their dephosphorylation an

222 We also describe that the protein phosphatase Cdc14 is implicated in Swe1 regulati

223 ) or control of RPA phosphorylation (the PP4 protein phosphatase complex) are not recruited to the ge

224 ors by comparison with the reported vanadium-protein phosphatase complexes.

225 ted this specificity and found that distinct protein phosphatases counteract Ssp1 activity toward its

226 nine phosphatase motif (TPM), and a tyrosine protein phosphatase domain.

227 PRR complexes are under tight control by protein phosphatases, E3 ligases, and other regulatory p

228 Cell detachment induces several protein phosphatases, five of which - DUSP6, PPTC7, PTPN

229 on of Gadd34 (Ppp1r15A),which targets type 1 protein phosphatase for dephosphorylation of eIF2alpha-P

230 rypanosoma brucei, as the translocation of a protein phosphatase from the cytosol forms part of a cru

231 horylated ABI5 may prevent PP2A or PP2A-like protein phosphatases from removing the phosphate from AB

232 rstanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of kno

233 e characterize a mitochondrial IMS-localized protein phosphatase identified in photosynthetic eukaryo

234 us on comprehensively identifying and naming protein phosphatases in available apicomplexan genomes,

235 The role of protein phosphatases in pathogenic bacteria has been stu

236 vity by interacting with casein kinase-2 and protein phosphatases in the hypothalamus and that imbala

237 directly interacts with several clade A PP2C protein phosphatases, including ABI1.

238 presence of micromolar concentrations of the protein phosphatase inhibitor okadaic acid, implicating

239 ic calmodulin mutants or pretreatment with a protein phosphatase inhibitor, calyculin A.

240 Protein phosphatase inhibitors are often considered as t

241 Knockdown of 29 protein phosphatases interfered with SMN accumulation in

242 nd PP6, are multifunctional serine/threonine protein phosphatases involved in many cellular processes

243 also inhibited the increase, implying that a protein phosphatase is involved.

244 persensitive germination3 (AHG3), encoding a protein phosphatase, is specifically transcribed in the

245 kt and PHLPP1 (PH domain leucine-rich repeat protein phosphatase isoform 1), a Ser473-specific Akt ph

246 ent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and PP2A, appear directly

247 Protein phosphatase magnesium dependent 1A (PPM1A) has b

248 Loss of expression of protein phosphatase magnesium-dependent 1A during kidney

249 Protein phosphatase magnesium-dependent-1A (PPM1A) depho

250 endent engagement of specific members of the protein phosphatase metallo-dependent (PPM/PP2C) family

251 ne carboxyl methyltransferase 1 (LCMT-1) and protein phosphatase methylesterase 1 (PME-1) and regulat

252 ce that overexpress the PP2A methylesterase, protein phosphatase methylesterase-1 (PME-1), or the PP2

253 The common rs1440581 T allele in the protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K) gene

254 he phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP) downstream of PTEN is highly

255 eckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) suppresses receptor tyrosine

256 onstrated that PH domain leucine-rich repeat protein phosphatase (PHLPP), a novel family of Ser/Thr p

257 Here we show that the protein phosphatase Phlpp1 regulates endochondral ossifi

258 eins via hyperactivation of the Mn-dependent protein phosphatase PhpP, a key enzyme involved in the r

259 The data imply that an allosteric SR protein-phosphatase platform balances phosphorylation le

260 Protein phosphatases play vital roles in phosphorylation

261 osphatase (PHLPP), a novel family of Ser/Thr protein phosphatases, plays an important role in regulat

262 copy (MS) analysis, which identified several protein phosphatases (PP), including PP2A A and C subuni

263 hat balances the activities of SRPK1 and the protein phosphatase PP1, thereby regulating the phosphor

264 Type I protein phosphatase (PP1), in particular, has been shown

265 its positive functional influence on type I protein phosphatase (PP1), likely resulting in negative

266 The catalytic activity of the protein phosphatase PP2A has been implicated in the regu

267 hat KAP1 (KRAB-associated protein 1) and the protein phosphatase PP2A interact with URI.

268 ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A.

269 ced obesity via a mechanism involving type 2 protein phosphatase (PP2A) dephosphorylation of endothel

270 caffolding A subunit of the serine/threonine protein phosphatase, PP2A, and that phosphorylation of A

271 tor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the ki

272 ys were used to assess the expression of the protein phosphatase PP5 in endobronchial biopsies and AS

273 High-level amplification of the protein phosphatase PPM1D (WIP1) is present in a subset

274 ase domain related to the eukaryotic phospho-protein phosphatase (PPP) family.

275 I-mediated signaling, consisting of WHIP and protein phosphatase PPP6C.

276 kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium development

277 ca mutant plants, revealing that active PP2C protein phosphatases protect and stabilize RopGEF1 from

278 Here we report that the lipid and protein phosphatase, PTEN, has a novel role in the nucle

279 kinases are popular drug targets, targeting protein phosphatases remains a challenge.

280 pathways and disease pathologies, targeting protein phosphatases remains an underexplored opportunit

281 EMENT In the present study, we show that the protein phosphatase Shp2 is an important mediator of oli

282 GULATORY COMPONENT OF ABA RECEPTORS, TYPE 2C PROTEIN PHOSPHATASE Sucrose non-fermenting1-related prot

283 ed in photosynthetic eukaryotes as well as a protein phosphatase target of the highly conserved eukar

284 PTEN is a lipid/protein phosphatase that also has nuclear phosphatase-in

285 sphorylation by inhibiting the activity of a protein phosphatase that constitutively dephosphorylates

286 dc55) is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular

287 hosphatase 2 (AtSLP2) is a bona fide Ser/Thr protein phosphatase that is targeted to the mitochondria

288 pyruvate dehydrogenase kinase, and a type 2C protein phosphatase that may catalyze the dephosphorylat

289 m- and calmodulin-dependent serine/threonine protein phosphatase that plays a role in a wide range of

290 ly conserved transcriptional coactivator and protein phosphatase that plays vital roles in multiple d

291 y establish a functional precedent for CDC25 protein phosphatases that lies outside of their canonica

292 ancy pathways converge at clade A of type 2C protein phosphatases.The DOG1 protein is a major regulat

293 tly reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to re

294 Protein phosphatase type 2A complex (PP2A) has been know

295 Serine/threonine protein phosphatase type-1 (PP1), a major phosphatase in

296 ecipitation experiments demonstrated loss of protein phosphatases type 1 and type 2 from the RyR comp

297 The serine/threonine protein phosphatases type 2A (PP2A) are implicated in se

298 ations is suppressed by inactivation of PhpP protein phosphatase, which concomitantly restores protei

299 enously phosphorylated Pah1 by the Nem1-Spo7 protein phosphatase, which is highly specific for the si

300 DUSP3 is a small dual-specificity protein phosphatase with an unknown physiological functi