ライフサイエンスコーパス: protein phosphorylation

1 tory subunit of human PI3Kalpha in lipid and protein phosphorylation.

2 ctivation induces TIS11b gene expression and protein phosphorylation.

3 etate (NCA) and diamide induced reproducible protein phosphorylation.

4 es, and vesicle trafficking, and can mediate protein phosphorylation.

5 phas-dependent cAMP response element-binding protein phosphorylation.

6 thereby stimulate protein synthesis through protein phosphorylation.

7 otosystem II (PSII) light-harvesting complex protein phosphorylation.

8 ts a versatile approach for the detection of protein phosphorylation.

9 (PBS) also caused significant alteration of protein phosphorylation.

10 expression is only moderately predictive of protein phosphorylation.

11 erties of storage starch and is regulated by protein phosphorylation.

12 hat cover the important field of prokaryotic protein phosphorylation.

13 over 3000 proteins in a manner analogous to protein phosphorylation.

14 ion and degranulation, or post-translational protein phosphorylation.

15 plasticity and cAMP response element-binding protein phosphorylation.

16 ent that leads to RB1 inactivation following protein phosphorylation.

17 idue-resolved quantitative information about protein phosphorylation.

18 e (AMPK)-dependent signaling, but also on S6 protein phosphorylation.

19 beling to assess absolute stoichiometries of protein phosphorylation.

20 a signal transduction pathway that involves protein phosphorylation.

21 e of STN8 completely abolished all PSII core protein phosphorylation.

22 ts that also led to an increase in PSII core protein phosphorylation.

23 ity at the post-translational level, e.g. by protein phosphorylation.

24 ed with genes involved in cell signaling and protein phosphorylation.

25 hat bind tightly to RS domains, enhancing SR protein phosphorylation.

26 protein kinase (PKA) and subsequent cardiac protein phosphorylation.

27 hibiting Chlamydomonas TOR kinase on dynamic protein phosphorylation.

28 f cell division and as a global regulator of protein phosphorylation.

29 cific cycling dynamics comparable to that of protein-phosphorylation.

30 effect on calyculin A-induced contraction or protein phosphorylations.

31 ted by distinct signalling modules involving protein phosphorylations.

32 Living organisms have evolved protein phosphorylation, a rapid and versatile mechanism

33 uorescently marked PC12 cells with sustained protein phosphorylation activity.

34 Tumor protein phosphorylation analysis may provide insight int

35 post-translational modifications, including protein phosphorylation and acetylation.

36 owever, hallmarks of cancer such as aberrant protein phosphorylation and calcium-mediated cell signal

37 eatment resulted in decreased retinoblastoma protein phosphorylation and cell cycle G(2)/M arrest.

38 Within the core molecular clock, protein phosphorylation and degradation play a vital rol

39 The balance between protein phosphorylation and dephosphorylation is critica

40 vision cycle requires tight coupling between protein phosphorylation and dephosphorylation.

41 nly a small subset of patients had increased protein phosphorylation and elevated gene expression pos

42 n phenomenon that is associated with altered protein phosphorylation and enhanced PSI cyclic electron

43 proteins, both components take advantage of protein phosphorylation and flexibility to switch confor

44 mor growth by decreasing retinoblastoma (RB) protein phosphorylation and inducing cell cycle arrest a

45 To date, protein phosphorylation and kinase expression have been

46 ng, peroxisome function, disease resistance, protein phosphorylation and light perception, including

47 of mutations, including one that eliminates protein phosphorylation and may alter division.

48 Protein phosphorylation and membrane proteins play an im

49 ctive Syk mediated linker adaptor for T cell protein phosphorylation and membrane signalosome formati

50 r, myofilament Ca(2+) sensitivity depends on protein phosphorylation and muscle length, and at presen

51 ntraction can be used as a tool to study how protein phosphorylation and mutant proteins alter access

52 TPase-activating protein DEPDC1B induces ERK protein phosphorylation and N-Myc protein stabilization.

53 rminal NF-kappaBeta2 critical site affecting protein phosphorylation and nuclear translocation, resul

54 l-oxidizing agent diamide on cardiac myocyte protein phosphorylation and oxidation.

55 nts across the nuclei, by mechanisms such as protein phosphorylation and rapid changes in channel syn

56 lar processes in an intricate interplay with protein phosphorylation and serves as a key sensor of nu

57 rtant in presynaptic terminals in regulating protein phosphorylation and short term synaptic plastici

58 However, predictions of protein phosphorylation and signaling networks remain a

59 We detected the alterations in protein phosphorylation and signaling pathways in pancre

60 cal processes: myeloid cell differentiation, protein phosphorylation and synaptic signaling.

61 tyrosine kinases with diverse mechanisms of protein phosphorylation and the "eukaryote-like" Hanks-t

62 f Stt7 and Stl1 protein kinases, we examined protein phosphorylation and the state transition phenome

63 suggest that extensive erythrocyte membrane protein phosphorylation and ubiquitination are involved

64 ork involved in MPs formation exhibited more protein phosphorylation and ubiquitination in SCD patien

65 g post-translational modification, including protein phosphorylation and ubiquitination pathways, ass

66 regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows th

67 bition by alanine, 2) mimicked inhibition by protein phosphorylation, and 3) prevented binding of fru

68 increased swelling, potassium loss, aberrant protein phosphorylation, and dysregulated energy metabol

69 xpression, subcellular protein localization, protein phosphorylation, and tissue morphogenesis.

70 Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data ident

71 aft rearrangement and subsequent decrease of protein phosphorylation are central in EFV effects and e

72 All domains of life utilize protein phosphorylation as a mechanism of signal transdu

73 Although protein phosphorylation as a mode of eukaryotic cell reg

74 activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of repre

75 eria, however, are not commonly known to use protein phosphorylation as part of their defense against

76 Protein phosphorylation at distinct tyrosine residues (p

77 cells also displayed an upregulation of IRS1 protein phosphorylation at serine-312 at baseline (witho

78 ssion and was associated with retinoblastoma protein phosphorylation attenuation, which resulted in G

79 sclosed a moss-specific pattern of thylakoid protein phosphorylation, both with respect to specific t

80 c stimulation of the betaAR not only induces protein phosphorylation but also activates nitric oxide-

81 normal B lymphocytes, HB57-dex induced less protein phosphorylation but more cell proliferation and

82 Protein phosphorylation by cyclic AMP-dependent protein

83 MCM8 bound cyclin D1 and activated Rb protein phosphorylation by cyclin-dependent kinase 4 in

84 real-time electrochemical monitoring of the protein phosphorylation by detecting the release of prot

85 Protein phosphorylation by eukaryotic protein kinases (e

86 Scaffold proteins can enhance protein phosphorylation by facilitating an interaction b

87 t binding of SH2 and PTB domains can enhance protein phosphorylation by protecting the sites bound by

88 cations of myofilament proteins, myofilament protein phosphorylation by ROS-activated signaling enzym

89 reduction of GpsB amount leads to decreased protein phosphorylation by StkP and report that the esse

90 out to identify mechanisms of specificity in protein phosphorylation by YopO that would clarify its e

91 Disruption of regulatory protein phosphorylation can lead to disease and is parti

92 pathways as follows: rapidly through direct protein phosphorylation cascades and slowly through indi

93 bservations that growth factor responses and protein phosphorylation cascades are intimately linked t

94 f genomic transcription triggered by protein-protein phosphorylation cascades initiated at membrane r

95 signaling module downstream of PRRs, linking protein phosphorylation cascades to metabolic regulation

96 elease of protons (H(+)) associated with the protein phosphorylation catalysed by kinases.

97 Reversible protein phosphorylation catalyzed by protein kinases and

98 Protein phosphorylation catalyzed by protein kinases pla

99 ell-intrinsic mechanism whereby differential protein phosphorylation causes splicing-dependent altera

100 ranscription, regulation of gene expression, protein phosphorylation, cell wall organization.

101 regulation of transcription and translation, protein phosphorylation, cellular signal transduction, a

102 The intra-species protein phosphorylation challenge organized by the IMPRO

103 s that allow proteome-wide quantification of protein phosphorylation changes (phosphoproteomics).

104 Although protein phosphorylation clearly affects Shh signaling, l

105 hat mechanisms of viral defense that rely on protein phosphorylation constitute a conserved antiviral

106 Dynamic protein phosphorylation constitutes a fundamental regula

107 Protein phosphorylation controls major processes in cell

108 ailed molecular understanding of ADP-induced protein phosphorylation could identify (1) critical hubs

109 Protein phosphorylation, critical for cellular regulator

110 lock of the cyanobacterium S. elongatus is a protein phosphorylation cycle consisting of three protei

111 Gene expression and protein phosphorylation data are available from ArrayExp

112 Gene sets, gene expression and protein phosphorylation data are available on request.

113 ytokinin sensitivity correlates with the PIN protein phosphorylation degree.

114 Enhanced myofilament protein phosphorylation detected after hRFRP-1 treatment

115 Reversible protein phosphorylation determines growth and adaptive d

116 The reversible nature of protein phosphorylation dictates that any protein kinase

117 1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1.

118 ure in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activ

119 pearance and physiological role of thylakoid protein phosphorylation during evolution of oxygenic pho

120 uxes, production of reactive oxygen species, protein phosphorylation, ethylene biosynthesis and callo

121 omatal closure, was regulated via reversible protein phosphorylation events involving ABA signaling c

122 The identification of dynamic protein phosphorylation events is critical for understan

123 Biochemical investigation of protein phosphorylation events is limited by inefficient

124 Thus, protein phosphorylation events responsive to 5 min of 0.

125 also comes from monitoring the reduction of protein phosphorylation events that characterize the int

126 e trafficking and degradation, regulators of protein phosphorylation, GTPases, and a number of protei

127 Protein phosphorylation has a key role in cell regulatio

128 The effect this protein phosphorylation has on muscle mechanics during a

129 and structural consequences of site-specific protein phosphorylation has remained limited by our inab

130 d to other types of modifications of the Sp1 protein, phosphorylation has been studied far more exten

131 al studies, but the effects of postmortem on protein phosphorylation have not been received enough at

132 arrays (TIRF-PBM) to evaluate the effects of protein phosphorylation, higher-order polymerization and

133 n kinase protein complex 1 (mTORC1)-targeted protein phosphorylation, (ii) inhibited translation of a

134 The PRISM-SRM quantification of protein phosphorylation illustrates the potential for si

135 heterogeneity in PP1 activity and downstream protein phosphorylation in AF may be attributed to alter

136 low basically allow simultaneous analysis of protein phosphorylation in B cell (sub)populations, with

137 reactive oxygen species (ROS) levels and Src protein phosphorylation in CD34(+) cells.

138 studies have suggested a role for Ca(2+) and protein phosphorylation in CO(2) -induced stomatal closi

139 To characterize protein phosphorylation in developing seed, a large-scal

140 ive mass spectrometry to identify changes in protein phosphorylation in ETAA1- or TOPBP1-deficient ce

141 s of investigation into the role of secreted protein phosphorylation in human biology and disease.

142 ls the previously unappreciated diversity of protein phosphorylation in human cells, and opens up ave

143 Here, we provide direct evidence that protein phosphorylation in individual living mammalian c

144 ked maximal-intensity contractions (MICs) on protein phosphorylation in mouse skeletal muscle.

145 Methotrexate did not affect protein phosphorylation in other intracellular signallin

146 reports have revealed the regulatory role of protein phosphorylation in photosynthesis, various other

147 hat GpsB plays a key - but unknown - role in protein phosphorylation in pneumococci.

148 d increased protein kinase A (PKA)-dependent protein phosphorylation in purified medullary ICs that w

149 signaling molecules, and tight junction (TJ) protein phosphorylation in response to a 2 degrees C ris

150 ates an extensive spectrum of human platelet protein phosphorylation in response to ADP and Iloprost,

151 in kinases and reveal an unexpected role for protein phosphorylation in spore biology.

152 Here, we analyzed thylakoid protein phosphorylation in the moss Physcomitrella paten

153 ased after 1 h of 40 Hz flicker stimulation, protein phosphorylation in the NF-kappaB pathway was upr

154 us agents through a mechanism which involves protein phosphorylation in the nucleus.

155 urthermore, BnMPK4 activation also increased protein phosphorylation in the phosphoproteome, from whi

156 genetic and pharmacological perturbations of protein phosphorylation in vivo.

157 ate a comprehensive and detailed map of IL-2 protein phosphorylations in cytotoxic T cells (CTL).

158 re to WIN enhances the effects of cocaine on protein phosphorylation, including ERK/MAPK-targets like

159 P responses include changes in intracellular protein phosphorylation, including the activation of mit

160 n during locomotor sensitization, basal SGK1 protein phosphorylation increased despite blunting of Sg

161 post-translational modification analogous to protein phosphorylation; increased intracellular protein

162 anization, extensive changes in the state of protein phosphorylation, increases in intracellular pH (

163 tative phosphoproteome analysis, we examined protein phosphorylation induced by SDF-1/CXCR4 signaling

164 effects of AEE788, proteome-wide changes in protein phosphorylation induced by the drug were determi

165 ctivity, CREB (cAMP-response element-binding protein) phosphorylation, induction of p21, and growth i

166 s for the label-free real-time monitoring of protein phosphorylation inside cells.

167 asurements such as gene expression levels or protein phosphorylation intensities are collected sequen

168 es that are being commonly employed to sense protein phosphorylation, introduces a few novel and attr

169 Protein phosphorylation is a central mechanism of signal

170 dicate that mTORC2-catalyzed cotranslational protein phosphorylation is a core function of this compl

171 Protein phosphorylation is a critical post-translational

172 Period (PER) protein phosphorylation is a critical regulator of circa

173 Protein phosphorylation is a dynamic post-translational

174 Protein phosphorylation is a key post-translational modi

175 Protein phosphorylation is a key regulator of protein fu

176 In all eukaryotes, protein phosphorylation is a key regulatory mechanism in

177 Protein phosphorylation is a major form of post-translat

178 Protein phosphorylation is a post-translational modifica

179 Protein phosphorylation is a reversible regulatory proce

180 Protein phosphorylation is a ubiquitous post-translation

181 Reversible protein phosphorylation is an essential post-translation

182 Protein phosphorylation is an essential step for the exp

183 Reversible protein phosphorylation is an important and ubiquitous p

184 Protein phosphorylation is an important post-translation

185 vides strong evidence that the regulation of protein phosphorylation is critical for driving successf

186 Protein phosphorylation is critical for regulating cellu

187 However, protein phosphorylation is determined by the balance of

188 Protein phosphorylation is one of the most prominent pos

189 Programmable protein phosphorylation is poised to help reveal the str

190 Protein phosphorylation is the best characterized post-t

191 Protein phosphorylation is the most common post-translat

192 Protein phosphorylation is the most common post-translat

193 portant and perfusion has to be avoided when protein phosphorylation is to be studied.

194 ation of gene expression, its crosstalk with protein phosphorylation is vital for cell signaling.

195 a protein substrate, a modification known as protein phosphorylation, is catalyzed by protein kinases

196 response, (ii) epidermal development, (iii) protein phosphorylation, (iv) regulation of catalytic ac

197 esis, metabolic process, catalytic activity, protein phosphorylation, kinase activity, pollination, a

198 Biopsies were analyzed for protein phosphorylation, kinase activity, protein-protei

199 of the TAF1/TAF7 interaction within TFIID by protein phosphorylation leads to activation of TAF1 HAT

200 The protein phosphorylation level of seven individual protei

201 y states, which allows us to incorporate the protein phosphorylation level, pharmacological intervent

202 y characterized by pronounced changes in the protein phosphorylation level.

203 ectral features, correlating with changes in protein phosphorylation levels and the subsequent develo

204 Using gene expression to infer changes in protein phosphorylation levels induced in cells by vario

205 ve applied such algorithms to data measuring protein phosphorylation levels, assuming that the phosph

206 ischemia and ischemia-associated changes in protein phosphorylation levels, which can misguide the e

207 in phosphatase, which concomitantly restores protein phosphorylation levels.

208 ers, namely Il1b and TNFa mRNA and IKB-alpha protein phosphorylation levels.

209 Their tight regulation by small GTPases and protein phosphorylation make interrogation of these key

210 g pathways, however, suggest that catalyzing protein phosphorylation may not be the only function of

211 lopment are largely controlled by changes in protein phosphorylation mediated by signaling pathways a

212 Protein phosphorylation, mediated by protein kinases, pl

213 Protein phosphorylation mediates essentially all aspects

214 Orm protein phosphorylation mediating feedback regulation of

215 d modules, including regulation of hormones, protein phosphorylation, meristem development and epigen

216 B. subtilis hints at the importance of this protein phosphorylation module in the morphogenesis of t

217 nanoplasmonic sensing makes the detection of protein phosphorylation more reliable and effective.

218 In addition, we have found indications of protein phosphorylation near the N-terminal Arg and the

219 making it difficult to reconstruct the true protein phosphorylation network.

220 xidative stress-derived redox signalling and protein phosphorylation networks and serve as a resource

221 We show that common protein phosphorylation networks can implement optimal d

222 Protein phosphorylation networks play an important role

223 k significantly enhances causal discovery of protein phosphorylation networks.

224 Reversible protein phosphorylation of MEI-1 may ensure temporal act

225 In experiments with recombinant proteins, phosphorylation of recombinant human PDE3A iso

226 premier tool for identifying and quantifying protein phosphorylation on a global scale.

227 nd on accurate methods to quantify levels of protein phosphorylation on a global scale.

228 e mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.

229 in the past 3 decades came as a surprise, as protein phosphorylation on Ser, Thr, and Tyr amino acids

230 Reversible protein phosphorylation on serine, threonine, and tyrosi

231 ling, to detect the effects of site-specific protein phosphorylation on the thermal stability of thou

232 In contrast, protein phosphorylation on Tyr has not been described pr

233 An appropriate level of protein phosphorylation on tyrosine is essential for cel

234 ter matrices, and exhibit a range of altered protein phosphorylation or protein conformational change

235 llosteric inhibitor, 2) prevented inhibitory protein phosphorylation, or 3) mimicked allosteric activ

236 , high-frequency depression does not involve protein phosphorylation- or calpain-dependent mechanisms

237 t the NCA-mediated effect on cardiac myocyte protein phosphorylation orchestrates alterations in the

238 long been dominated by the investigation of protein phosphorylation; other PTMs, such as methylation

239 mbrane to the actin cytoskeleton by membrane protein phosphorylation, our data suggest an actin-depen

240 nd plants, distinct differences in thylakoid protein phosphorylation patterns have emerged from studi

241 Protein phosphorylation plays a central role in creating

242 Multisite protein phosphorylation plays a critical role in cell re

243 Reversible protein phosphorylation plays a critical role in cell si

244 While reversible protein phosphorylation plays an important role in many

245 Protein phosphorylation plays important roles in short-t

246 tional modification of the proteome, such as protein phosphorylation, plays a fundamental role in the

247 e expression data from 26 stimuli to develop protein phosphorylation prediction models and were ranke

248 propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination

249 e, this is the first report of assessment of protein phosphorylation quantification on eIF3.

250 Reversible protein phosphorylation regulated by kinases and phospha

251 Protein phosphorylation regulates numerous cellular proc

252 ein can govern its mitophagic fate, and that protein phosphorylation regulates these determinants.

253 Protein phosphorylation regulates virtually all biologic

254 Analysis of protein phosphorylation remains a significant challenge

255 The low stoichiometry of protein phosphorylation requires sensitive analysis by t

256 h orthovanadate or fluoride yielded a global protein phosphorylation response and rapid release of MP

257 the genes that convert Ca(2+) signal (CS) to protein phosphorylation responses (PPRs) remain highly c

258 -challenges was devoted to the prediction of protein phosphorylation responses in human bronchial epi

259 mutation; and (3) measurements of force and protein phosphorylation responses to cholinergic neurost

260 ntal and developmental signals to downstream protein phosphorylation responses.

261 ta on gene expression, pathway activity, and protein phosphorylation, revealed similarities among neu

262 ays known to be involved with cancer such as protein phosphorylation, signaling, gene regulation, and

263 The stoichiometry of protein phosphorylation significantly impacts protein fu

264 encoding schemes to develop a rice-specific protein phosphorylation site predictor.

265 Most known IF protein phosphorylation sites are serines localized in t

266 ally-determined or computationally-predicted protein phosphorylation sites for distinctive species ar

267 _phospho 1.0 outputs reliable predictions of protein phosphorylation sites in rice, and will serve as

268 s spectrometry (MS) is vital for identifying protein phosphorylation sites involved in cellular regul

269 We identified >6,000 protein phosphorylation sites that can be used to infer

270 lex, is associated with an abnormal membrane protein phosphorylation state, with destabilization of t

271 ights into the spatiotemporal control of the protein phosphorylation state.

272 trast to a similar cross-species response in protein phosphorylation states 5 and 25 min after exposu

273 come indicates that successful prediction of protein phosphorylation status in human based on rat pho

274 nt activation, cooperativity, and sarcomeric protein phosphorylation status.

275 an autonomous mechanism for break-localized protein phosphorylation that generates sub-nuclear foci.

276 lated largely through dynamic and reversible protein phosphorylation that is modulated by opposing ac

277 have made it possible to monitor changes in protein phosphorylation that occur at different steps in

278 metry-based workflow to study the changes in protein phosphorylation that occur in mouse skeletal mus

279 the further understanding of the networks of protein phosphorylation that program CTL fate.

280 iques, we analyzed changes in BCR-stimulated protein phosphorylation that were dependent on the activ

281 A-dependent cAMP-responsive element-binding protein phosphorylation, the effect of changing the prof

282 lter nucleotide exchange and, thus, regulate protein phosphorylation, the presence of activating resi

283 The importance of reversible protein phosphorylation to cellular regulation cannot be

284 nnels as target sensors for nitric oxide and protein phosphorylation together with high concentration

285 In this work, we assessed STT7-dependent protein phosphorylation under high light in C. reinhardt

286 gulation of signaling pathways controlled by protein phosphorylation underlies the pathogenesis of he

287 pite distinct changes occurring in thylakoid protein phosphorylation upon light intensity changes, th

288 e STT7 protein substrates and STT7-dependent protein phosphorylation variations that were reliant on

289 anding challenge for the characterization of protein phosphorylation via conventional mass spectromet

290 In bacteria, protein phosphorylation was classically thought to be me

291 , progression through mitosis is driven by a protein phosphorylation wave.

292 ight into the role and dynamics of thylakoid protein phosphorylation, we used targeted proteomics to

293 o different case studies-gene expression and protein phosphorylation-we demonstrate the sensitivity o

294 No changes in thin filament protein phosphorylation were evident.

295 , and western blotting quantification of the protein phosphorylation were used for the assessment of

296 olved in defense response, wound healing and protein phosphorylation when compared to normal human pl

297 single-molecule, site-specific detection of protein phosphorylation with protein nanopore technology

298 We now present evidence indicating that protein phosphorylation within the mitochondrial matrix

299 20C, and this complex enhances extracellular protein phosphorylation within the secretory pathway.

300 as accompanied by decreases in ERK2 mRNA and protein phosphorylation within the VTA, while stress alo