ライフサイエンスコーパス: protein phosphorylation

1 ts a versatile approach for the detection of protein phosphorylation.

2 (PBS) also caused significant alteration of protein phosphorylation.

3 expression is only moderately predictive of protein phosphorylation.

4 erties of storage starch and is regulated by protein phosphorylation.

5 hat cover the important field of prokaryotic protein phosphorylation.

6 over 3000 proteins in a manner analogous to protein phosphorylation.

7 plasticity and cAMP response element-binding protein phosphorylation.

8 ent that leads to RB1 inactivation following protein phosphorylation.

9 idue-resolved quantitative information about protein phosphorylation.

10 e (AMPK)-dependent signaling, but also on S6 protein phosphorylation.

11 beling to assess absolute stoichiometries of protein phosphorylation.

12 otubule network and cell signaling involving protein phosphorylation.

13 M2-7/GINS (CMG) complex, can be inhibited by protein phosphorylation.

14 o enhanced SRPK nuclear translocation and SR protein phosphorylation.

15 se domains can be dramatically influenced by protein phosphorylation.

16 membrane, which is regulated in part by ERM protein phosphorylation.

17 and to achieve rigorous characterization of protein phosphorylation.

18 essential and novel regulatory mechanism for protein phosphorylation.

19 eedback loop involving PKM Apl III-dependent protein phosphorylation.

20 o probe many biological processes, including protein phosphorylation.

21 g identical infusions to measure myofilament protein phosphorylation.

22 not necessary or sufficient for exclusion or protein phosphorylation.

23 ished through glucose-6-phosphate levels and protein phosphorylation.

24 tory subunit of human PI3Kalpha in lipid and protein phosphorylation.

25 ctivation induces TIS11b gene expression and protein phosphorylation.

26 es, and vesicle trafficking, and can mediate protein phosphorylation.

27 phas-dependent cAMP response element-binding protein phosphorylation.

28 thereby stimulate protein synthesis through protein phosphorylation.

29 otosystem II (PSII) light-harvesting complex protein phosphorylation.

30 cific cycling dynamics comparable to that of protein-phosphorylation.

31 effect on calyculin A-induced contraction or protein phosphorylations.

32 ted by distinct signalling modules involving protein phosphorylations.

33 Living organisms have evolved protein phosphorylation, a rapid and versatile mechanism

34 These results suggest that protein phosphorylation activates the enzyme, which supp

35 uorescently marked PC12 cells with sustained protein phosphorylation activity.

36 ts were used to detect protein expression or protein phosphorylation after immunoprecipitation by Wes

37 he conservation of known residues subject to protein phosphorylation among these natural strains.

38 Tumor protein phosphorylation analysis may provide insight int

39 n-independent signaling network that affects protein phosphorylation and autocrine/paracrine prostagl

40 eatment resulted in decreased retinoblastoma protein phosphorylation and cell cycle G(2)/M arrest.

41 Within the core molecular clock, protein phosphorylation and degradation play a vital rol

42 The balance between protein phosphorylation and dephosphorylation is critica

43 vision cycle requires tight coupling between protein phosphorylation and dephosphorylation.

44 nly a small subset of patients had increased protein phosphorylation and elevated gene expression pos

45 To date, protein phosphorylation and kinase expression have been

46 ng, peroxisome function, disease resistance, protein phosphorylation and light perception, including

47 of mutations, including one that eliminates protein phosphorylation and may alter division.

48 r, myofilament Ca(2+) sensitivity depends on protein phosphorylation and muscle length, and at presen

49 ntraction can be used as a tool to study how protein phosphorylation and mutant proteins alter access

50 rminal NF-kappaBeta2 critical site affecting protein phosphorylation and nuclear translocation, resul

51 efit was associated with increased signaling protein phosphorylation and O-GlcNAcylation.

52 Protein phosphorylation and protein ubiquitination regul

53 nts across the nuclei, by mechanisms such as protein phosphorylation and rapid changes in channel syn

54 lar processes in an intricate interplay with protein phosphorylation and serves as a key sensor of nu

55 rtant in presynaptic terminals in regulating protein phosphorylation and short term synaptic plastici

56 However, predictions of protein phosphorylation and signaling networks remain a

57 We detected the alterations in protein phosphorylation and signaling pathways in pancre

58 y reagents are valuable tools for monitoring protein phosphorylation and studying signaling events in

59 tyrosine kinases with diverse mechanisms of protein phosphorylation and the "eukaryote-like" Hanks-t

60 g post-translational modification, including protein phosphorylation and ubiquitination pathways, ass

61 nhibit CREB (cAMP-responsive element-binding protein) phosphorylation and thus decrease osteoblast pr

62 xpression, subcellular protein localization, protein phosphorylation, and tissue morphogenesis.

63 in accumulation, and Wiskott-Aldrich symptom protein phosphorylation are enhanced in SHIP-1(-/-) B ce

64 All domains of life utilize protein phosphorylation as a mechanism of signal transdu

65 Although protein phosphorylation as a mode of eukaryotic cell reg

66 activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of repre

67 eria, however, are not commonly known to use protein phosphorylation as part of their defense against

68 Protein phosphorylation assay confirmed that ERK1/2 dire

69 Protein phosphorylation at distinct tyrosine residues (p

70 ucible differences in protein expression and protein phosphorylation between embryonic stem cells and

71 ation, transcription, hormone responses, and protein phosphorylation but activate genes involved in p

72 c stimulation of the betaAR not only induces protein phosphorylation but also activates nitric oxide-

73 normal B lymphocytes, HB57-dex induced less protein phosphorylation but more cell proliferation and

74 only reveal processes that are regulated by protein phosphorylation, but also define potential anti-

75 nction is critically modulated by Ca(2+) and protein phosphorylation, but the interrelationship betwe

76 change alternative splicing and decrease SR-protein phosphorylation by activating protein phosphatas

77 Protein phosphorylation by cyclic AMP-dependent protein

78 MCM8 bound cyclin D1 and activated Rb protein phosphorylation by cyclin-dependent kinase 4 in

79 real-time electrochemical monitoring of the protein phosphorylation by detecting the release of prot

80 Scaffold proteins can enhance protein phosphorylation by facilitating an interaction b

81 t binding of SH2 and PTB domains can enhance protein phosphorylation by protecting the sites bound by

82 cations of myofilament proteins, myofilament protein phosphorylation by ROS-activated signaling enzym

83 reduction of GpsB amount leads to decreased protein phosphorylation by StkP and report that the esse

84 out to identify mechanisms of specificity in protein phosphorylation by YopO that would clarify its e

85 Disruption of regulatory protein phosphorylation can lead to disease and is parti

86 In disordered proteins, phosphorylation can tip the balance between or

87 pathways as follows: rapidly through direct protein phosphorylation cascades and slowly through indi

88 f genomic transcription triggered by protein-protein phosphorylation cascades initiated at membrane r

89 signaling module downstream of PRRs, linking protein phosphorylation cascades to metabolic regulation

90 elease of protons (H(+)) associated with the protein phosphorylation catalysed by kinases.

91 Reversible protein phosphorylation catalyzed by protein kinases and

92 Protein phosphorylation catalyzed by protein kinases pla

93 ranscription, regulation of gene expression, protein phosphorylation, cell wall organization.

94 The intra-species protein phosphorylation challenge organized by the IMPRO

95 Although protein phosphorylation clearly affects Shh signaling, l

96 hat mechanisms of viral defense that rely on protein phosphorylation constitute a conserved antiviral

97 Protein phosphorylation controls major processes in cell

98 ailed molecular understanding of ADP-induced protein phosphorylation could identify (1) critical hubs

99 lock of the cyanobacterium S. elongatus is a protein phosphorylation cycle consisting of three protei

100 Gene expression and protein phosphorylation data are available from ArrayExp

101 Gene sets, gene expression and protein phosphorylation data are available on request.

102 In the past few years, the Plant Protein Phosphorylation Database (P(3)DB, http://p3db.or

103 entire data set was uploaded into the Plant Protein Phosphorylation Database (www.p3db.org), includi

104 The Plant Protein Phosphorylation Database is a portal for all pla

105 ytokinin sensitivity correlates with the PIN protein phosphorylation degree.

106 Enhanced myofilament protein phosphorylation detected after hRFRP-1 treatment

107 Reversible protein phosphorylation determines growth and adaptive d

108 The reversible nature of protein phosphorylation dictates that any protein kinase

109 1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1.

110 Protein phosphorylation, driven by specific recognition

111 ure in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activ

112 applied a technique optimal for detection of protein phosphorylation, electron transfer dissociation,

113 uxes, production of reactive oxygen species, protein phosphorylation, ethylene biosynthesis and callo

114 omatal closure, was regulated via reversible protein phosphorylation events involving ABA signaling c

115 The identification of dynamic protein phosphorylation events is critical for understan

116 Biochemical investigation of protein phosphorylation events is limited by inefficient

117 Thus, protein phosphorylation events responsive to 5 min of 0.

118 ed insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regu

119 to perform high-resolution respirometry and protein phosphorylation/expression.

120 utant stn7/8 demonstrate the central role of protein phosphorylation for the structural alterations.

121 this step and consequently the efficiency of protein phosphorylation for these cases.

122 e trafficking and degradation, regulators of protein phosphorylation, GTPases, and a number of protei

123 Protein phosphorylation has a key role in cell regulatio

124 The effect this protein phosphorylation has on muscle mechanics during a

125 and structural consequences of site-specific protein phosphorylation has remained limited by our inab

126 d to other types of modifications of the Sp1 protein, phosphorylation has been studied far more exten

127 al studies, but the effects of postmortem on protein phosphorylation have not been received enough at

128 arrays (TIRF-PBM) to evaluate the effects of protein phosphorylation, higher-order polymerization and

129 n kinase protein complex 1 (mTORC1)-targeted protein phosphorylation, (ii) inhibited translation of a

130 The PRISM-SRM quantification of protein phosphorylation illustrates the potential for si

131 heterogeneity in PP1 activity and downstream protein phosphorylation in AF may be attributed to alter

132 nce indicating that AMN+LEP increased STAT-3 protein phosphorylation in Arc and VMH.

133 To characterize protein phosphorylation in developing seed, a large-scal

134 technology for the highly efficient assay of protein phosphorylation in high-throughput format withou

135 s of investigation into the role of secreted protein phosphorylation in human biology and disease.

136 Here, we provide direct evidence that protein phosphorylation in individual living mammalian c

137 proach to carry out an extensive analysis of protein phosphorylation in M. tuberculosis.

138 ked maximal-intensity contractions (MICs) on protein phosphorylation in mouse skeletal muscle.

139 Methotrexate did not affect protein phosphorylation in other intracellular signallin

140 reports have revealed the regulatory role of protein phosphorylation in photosynthesis, various other

141 reverse genetics to assess the importance of protein phosphorylation in Plasmodium falciparum asexual

142 hat GpsB plays a key - but unknown - role in protein phosphorylation in pneumococci.

143 d increased protein kinase A (PKA)-dependent protein phosphorylation in purified medullary ICs that w

144 signaling molecules, and tight junction (TJ) protein phosphorylation in response to a 2 degrees C ris

145 ates an extensive spectrum of human platelet protein phosphorylation in response to ADP and Iloprost,

146 Current techniques for detecting protein phosphorylation in single cells often involve th

147 in kinases and reveal an unexpected role for protein phosphorylation in spore biology.

148 d were associated with increased neuronal S6 protein phosphorylation in the brains of affected indivi

149 eptin promotes cAMP response element-binding protein phosphorylation in the extCeA, but not NAc, of l

150 The role of protein phosphorylation in the life cycle of malaria par

151 e analysis of both nascent transcription and protein phosphorylation in the tailbud, to distinguish e

152 genetic and pharmacological perturbations of protein phosphorylation in vivo.

153 ate a comprehensive and detailed map of IL-2 protein phosphorylations in cytotoxic T cells (CTL).

154 P responses include changes in intracellular protein phosphorylation, including the activation of mit

155 n during locomotor sensitization, basal SGK1 protein phosphorylation increased despite blunting of Sg

156 post-translational modification analogous to protein phosphorylation; increased intracellular protein

157 anization, extensive changes in the state of protein phosphorylation, increases in intracellular pH (

158 tative phosphoproteome analysis, we examined protein phosphorylation induced by SDF-1/CXCR4 signaling

159 effects of AEE788, proteome-wide changes in protein phosphorylation induced by the drug were determi

160 ctivity, CREB (cAMP-response element-binding protein) phosphorylation, induction of p21, and growth i

161 s for the label-free real-time monitoring of protein phosphorylation inside cells.

162 es that are being commonly employed to sense protein phosphorylation, introduces a few novel and attr

163 Protein phosphorylation is a central mechanism of signal

164 dicate that mTORC2-catalyzed cotranslational protein phosphorylation is a core function of this compl

165 Protein phosphorylation is a critical posttranslational

166 Period (PER) protein phosphorylation is a critical regulator of circa

167 Protein phosphorylation is a critical regulator of signa

168 Protein phosphorylation is a critical signaling mechanis

169 Protein phosphorylation is a dynamic post-translational

170 Protein phosphorylation is a fundamental mechanism regul

171 Dysregulated protein phosphorylation is a hallmark of malignant trans

172 Protein phosphorylation is a major form of post-translat

173 Protein phosphorylation is a post-translational modifica

174 Protein phosphorylation is a post-translational modifica

175 Protein phosphorylation is a reversible regulatory proce

176 Protein phosphorylation is a ubiquitous post-translation

177 Reversible protein phosphorylation is an essential regulatory compo

178 Protein phosphorylation is an essential step for the exp

179 Reversible protein phosphorylation is an important and ubiquitous p

180 Protein phosphorylation is an important and ubiquitous p

181 Protein phosphorylation is an important component of vas

182 Protein phosphorylation is an important post-translation

183 vides strong evidence that the regulation of protein phosphorylation is critical for driving successf

184 Protein phosphorylation is critical for regulating cellu

185 However, protein phosphorylation is determined by the balance of

186 The functional role of protein phosphorylation is impacted by its fractional st

187 Protein phosphorylation is one of the most prominent pos

188 Programmable protein phosphorylation is poised to help reveal the str

189 Protein phosphorylation is the hallmark of checkpoint ac

190 Protein phosphorylation is the most common post-translat

191 Protein phosphorylation is the most frequent post-transl

192 portant and perfusion has to be avoided when protein phosphorylation is to be studied.

193 Reversible protein phosphorylation is vital for many fundamental ce

194 Biopsies were analyzed for protein phosphorylation, kinase activity, protein-protei

195 ory factor 7, as indicated by either lack of protein phosphorylation, lack of nuclear accumulation, o

196 of the TAF1/TAF7 interaction within TFIID by protein phosphorylation leads to activation of TAF1 HAT

197 The protein phosphorylation level of seven individual protei

198 y characterized by pronounced changes in the protein phosphorylation level.

199 ectral features, correlating with changes in protein phosphorylation levels and the subsequent develo

200 Using gene expression to infer changes in protein phosphorylation levels induced in cells by vario

201 Protein phosphorylation levels were quantified by Wester

202 ischemia and ischemia-associated changes in protein phosphorylation levels, which can misguide the e

203 in phosphatase, which concomitantly restores protein phosphorylation levels.

204 cardial proteomics identified alterations in protein phosphorylation linked to the miR-499 cardiomyop

205 Their tight regulation by small GTPases and protein phosphorylation make interrogation of these key

206 g pathways, however, suggest that catalyzing protein phosphorylation may not be the only function of

207 ivation in satellite cells and inhibition of protein phosphorylation may provide a new therapeutic to

208 Complex patterns of protein phosphorylation mediate many cellular processes.

209 lopment are largely controlled by changes in protein phosphorylation mediated by signaling pathways a

210 Protein phosphorylation mediates essentially all aspects

211 Orm protein phosphorylation mediating feedback regulation of

212 Protein phosphorylation modulates centrosome function, a

213 nanoplasmonic sensing makes the detection of protein phosphorylation more reliable and effective.

214 We show that common protein phosphorylation networks can implement optimal d

215 We illustrate the approach in the context of protein phosphorylation networks, using data simulated f

216 We examined changes in protein phosphorylation occurring when HEK293 cells expr

217 rget of rapamycin (mTOR), and also increased protein phosphorylation of ERK2, CREB, and mTOR 2 months

218 nique autoregulatory mechanisms that control protein phosphorylation of human Chk1, as well as checkp

219 Reversible protein phosphorylation of MEI-1 may ensure temporal act

220 d retraction processes through intracellular protein phosphorylation of numerous cytoskeletal, adhesi

221 o investigate the postmortem (PM) changes in protein phosphorylation of the myofibrillar proteins in

222 In experiments with recombinant proteins, phosphorylation of recombinant human PDE3A iso

223 is well known that the GSK3 kinase-catalyzed protein phosphorylation often requires a stable kinase-s

224 nd on accurate methods to quantify levels of protein phosphorylation on a global scale.

225 ing to determine absolute stoichiometries of protein phosphorylation on a large scale.

226 Here we report that protein phosphorylation on arginine residues plays a phy

227 tudies, we also evaluated the effect of core protein phosphorylation on assembly and RNA binding, usi

228 e mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.

229 in the past 3 decades came as a surprise, as protein phosphorylation on Ser, Thr, and Tyr amino acids

230 In contrast, protein phosphorylation on Tyr has not been described pr

231 An appropriate level of protein phosphorylation on tyrosine is essential for cel

232 , high-frequency depression does not involve protein phosphorylation- or calpain-dependent mechanisms

233 long been dominated by the investigation of protein phosphorylation; other PTMs, such as methylation

234 mbrane to the actin cytoskeleton by membrane protein phosphorylation, our data suggest an actin-depen

235 Protein phosphorylation plays a central role in creating

236 Reversible protein phosphorylation plays a critical role in cell si

237 Reversible protein phosphorylation plays a major role in the acclim

238 While reversible protein phosphorylation plays an important role in many

239 tional modification of the proteome, such as protein phosphorylation, plays a fundamental role in the

240 e expression data from 26 stimuli to develop protein phosphorylation prediction models and were ranke

241 propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination

242 Protein phosphorylation provides a mechanism for the rap

243 e, this is the first report of assessment of protein phosphorylation quantification on eIF3.

244 Reversible protein phosphorylation regulated by kinases and phospha

245 Protein phosphorylation regulates numerous cellular proc

246 Protein phosphorylation regulates virtually all biologic

247 Analysis of protein phosphorylation remains a significant challenge

248 ed, the molecular mechanism and the sites of protein phosphorylation required for Ca(V)1 channel regu

249 The low stoichiometry of protein phosphorylation requires sensitive analysis by t

250 h orthovanadate or fluoride yielded a global protein phosphorylation response and rapid release of MP

251 the genes that convert Ca(2+) signal (CS) to protein phosphorylation responses (PPRs) remain highly c

252 -challenges was devoted to the prediction of protein phosphorylation responses in human bronchial epi

253 mutation; and (3) measurements of force and protein phosphorylation responses to cholinergic neurost

254 ntal and developmental signals to downstream protein phosphorylation responses.

255 Analysis of protein phosphorylation revealed approximately 25% reduc

256 n kinase C-dependent Raf-1 kinase inhibitory protein phosphorylation, sensitization of cholecystokini

257 ays known to be involved with cancer such as protein phosphorylation, signaling, gene regulation, and

258 The stoichiometry of protein phosphorylation significantly impacts protein fu

259 encoding schemes to develop a rice-specific protein phosphorylation site predictor.

260 Most known IF protein phosphorylation sites are serines localized in t

261 ally-determined or computationally-predicted protein phosphorylation sites for distinctive species ar

262 _phospho 1.0 outputs reliable predictions of protein phosphorylation sites in rice, and will serve as

263 s spectrometry (MS) is vital for identifying protein phosphorylation sites involved in cellular regul

264 lex, is associated with an abnormal membrane protein phosphorylation state, with destabilization of t

265 trast to a similar cross-species response in protein phosphorylation states 5 and 25 min after exposu

266 he actin binding by cMyBPC is independent of protein phosphorylation status and is not significantly

267 come indicates that successful prediction of protein phosphorylation status in human based on rat pho

268 " This effect was mediated by changes in the protein phosphorylation status of occludin via the actio

269 nt activation, cooperativity, and sarcomeric protein phosphorylation status.

270 Following in the footsteps of protein phosphorylation studies, new modifications are b

271 an autonomous mechanism for break-localized protein phosphorylation that generates sub-nuclear foci.

272 lated largely through dynamic and reversible protein phosphorylation that is modulated by opposing ac

273 have made it possible to monitor changes in protein phosphorylation that occur at different steps in

274 metry-based workflow to study the changes in protein phosphorylation that occur in mouse skeletal mus

275 the further understanding of the networks of protein phosphorylation that program CTL fate.

276 ible approach for the broadscale analysis of protein phosphorylation that relies on a single phosphop

277 thod for enhanced detection of low-abundance protein phosphorylation that uses selective introduction

278 iques, we analyzed changes in BCR-stimulated protein phosphorylation that were dependent on the activ

279 A-dependent cAMP-responsive element-binding protein phosphorylation, the effect of changing the prof

280 lter nucleotide exchange and, thus, regulate protein phosphorylation, the presence of activating resi

281 we used proteomics with special attention to protein phosphorylation to analyze the composition of th

282 The importance of reversible protein phosphorylation to cellular regulation cannot be

283 nnels as target sensors for nitric oxide and protein phosphorylation together with high concentration

284 nces of PKCalpha fragmentation on myocardial protein phosphorylation, transgenic mice were created co

285 In this work, we assessed STT7-dependent protein phosphorylation under high light in C. reinhardt

286 gulation of signaling pathways controlled by protein phosphorylation underlies the pathogenesis of he

287 pite distinct changes occurring in thylakoid protein phosphorylation upon light intensity changes, th

288 e STT7 protein substrates and STT7-dependent protein phosphorylation variations that were reliant on

289 anding challenge for the characterization of protein phosphorylation via conventional mass spectromet

290 In bacteria, protein phosphorylation was classically thought to be me

291 ct of protonation on amino acid monomers and protein phosphorylation was studied by means of a combin

292 , progression through mitosis is driven by a protein phosphorylation wave.

293 rom an underlying asymmetric distribution of protein phosphorylation, we use mathematical modeling to

294 o different case studies-gene expression and protein phosphorylation-we demonstrate the sensitivity o

295 No changes in thin filament protein phosphorylation were evident.

296 olved in defense response, wound healing and protein phosphorylation when compared to normal human pl

297 The best characterised PTM is protein phosphorylation which is reversibly catalysed at

298 single-molecule, site-specific detection of protein phosphorylation with protein nanopore technology

299 20C, and this complex enhances extracellular protein phosphorylation within the secretory pathway.

300 as accompanied by decreases in ERK2 mRNA and protein phosphorylation within the VTA, while stress alo