ライフサイエンスコーパス: protein prenylation

1 D) is characterized by a severe reduction in protein prenylation.

2 in-2 (SREBP-2) cleavage, causing decrease of protein prenylation.

3 terol trafficking secondary to inhibition of protein prenylation.

4 e synthase (FPPS) in osteoclasts, preventing protein prenylation.

5 carboxyl-terminal mutation used to eliminate protein prenylation.

6 ful to the community of researchers studying protein prenylation.

7 yl pyrophosphate synthase (FPPS) and inhibit protein prenylation.

8 ocalization was not altered by inhibitors of protein prenylation.

9 mino-terminal domain, even in the absence of protein prenylation.

10 with an isoprenyl lipid via a process called protein prenylation.

11 CAAX motif, a well-characterized signal for protein prenylation.

12 umulation appears dissociated from increased protein prenylation.

13 IFN-gamma in MVECs through interference with protein prenylation.

14 erol and isoprenoid synthesis, and increased protein prenylation.

15 , probably as a consequence of inhibition of protein prenylation.

16 zoledronic acid monohydrate, an inhibitor of protein prenylation, act synergistically to reverse outc

17 We conclude that protein prenylation, acting downstream of Hmgcr1b and po

18 ition of geranylgeranyl transferase 1 (GGT1) protein prenylation activity also resulted in abnormal g

19 In addition, aplexone treatment inhibits protein prenylation and blocking the activity of geranyl

20 we investigated the effect of lovastatin on protein prenylation and cell signaling.

21 a significant inhibitory effect of Abeta on protein prenylation and identify SREBP-2 as a target of

22 peptides that should be useful in studies of protein prenylation and other structurally related biolo

23 on a subbranch of the pathway important for protein prenylation, and showed improved mitochondrial f

24 ieties on proteins, differentiation specific protein prenylation, and the ability of peptidomimetic p

25 Significant to AD, reduced levels of protein prenylation are present in the cerebral cortex o

26 with its potential utility for the study of protein prenylation, are discussed.

27 ith concurrent reversal of the inhibition of protein prenylation as shown by protein RhoA geranylgera

28 in CD43 redistribution is through decreased protein prenylation because the cholesterol-dependent li

29 effects of FPP could not be accounted for by protein prenylation, because inhibition of farnesylation

30 The ability to measure protein prenylation before and after FTI and GGTI treatm

31 ts, we provide evidence that isoprenoids and protein prenylation, but not cholesterol, are required i

32 The pattern of protein prenylation by epithelial and fiber cells was si

33 describe protocols to measure the degree of protein prenylation by farnesyl transferase or geranylge

34 This study demonstrates that inhibition of protein prenylation by lovastatin leads to disruption of

35 dia containing 3H-mevalonolactone to examine protein prenylation by mevalonate-derived isoprenes.

36 ndicating that increased cellular demand for protein prenylation cannot explain increased statin sens

37 pyrophosphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, fo

38 cells with lovastatin, a drug that disrupts protein prenylation, changed the relative electrophoreti

39 hree post-translational processing reactions-protein prenylation, endoproteolysis, and carboxymethyla

40 l or geranylgeranyl lipids, a process called protein prenylation, facilitates interactions of protein

41 To determine whether protein prenylation (farnesyl/geranylgeranylation) regul

42 pleiotropic effects that establish roles for protein prenylation in abscisic acid (ABA) signaling and

43 synthesis of isoprenoid lipids required for protein prenylation in bone-resorbing osteoclasts.

44 of prenylated proteins and reveal a role for protein prenylation in host defense against viral infect

45 these peptides open the door for studies of protein prenylation in living cells, including enzymatic

46 beta production and elucidate the effects of protein prenylation in monocytes.

47 gulation in the synthesis of isoprenoids for protein prenylation in obesity might be a factor determi

48 on of clodronate and alendronate, effects on protein prenylation in osteoclasts and macrophages in vi

49 ese results demonstrate unique properties of protein prenylation in P. falciparum: a limited specific

50 an cells and yeast, however, the function of protein prenylation in plants is not well understood and

51 or farnesol (FOH) to investigate the role of protein prenylation in platelet-derived growth factor (P

52 sferase specificity and functional roles for protein prenylation in Rho GTPase function.

53 d showed improved mitochondrial function and protein prenylation in the presence of statins.

54 not squalene, indicating the involvement of protein prenylation in this process.

55 cant progress has been made in understanding protein prenylation in vitro, we have been interested in

56 a an arteriovenous-dependent requirement for protein prenylation in zebrafish and human endothelial c

57 nyl pyrophosphate (GGPP), which are used for protein prenylation, including the oncoproteins of the R

58 Protein prenylation, involving the alkylation of a speci

59 Protein prenylation is a common post-translational modif

60 Protein prenylation is a post-translational modification

61 Protein prenylation is a post-translational modification

62 Protein prenylation is a posttranslational lipid modific

63 Inhibiting protein prenylation is an attractive means to modulate c

64 Protein prenylation is carried out by a pair of cytosoli

65 mised individuals, is one pathogen for which protein prenylation is essential for survival.

66 Protein prenylation is required for a variety of growth

67 f prenyltransferase inhibitors indicate that protein prenylation is required for malaria parasite dev

68 Although protein prenylation is widely studied, there are few goo

69 osis induced by statins (other inhibitors of protein prenylation) is dependent on protein synthesis.

70 inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, markedly increased cytosolic accumu

71 in-vitro studies suggest that inhibition of protein prenylation may underlie the myotoxic effects of

72 Protein prenylation occurs in the protozoan that causes

73 We have previously shown that protein prenylation occurs in the Trypanosomatids Trypan

74 It is not clear how protein prenylation of small GTPases relates to GTP hydr

75 production versus mevalonate pathway-driven protein prenylation, on the emergence of the so-called p

76 plants were treated with some inhibitors of protein prenylation or by further monoterpenes.

77 the last of the three-step posttranslational protein prenylation process for the so-called CaaX prote

78 ence on both sterol metabolite synthesis and protein prenylation processes.

79 o oAbeta(42)-treated neurons recovers normal protein prenylation, reduces cholesterol sequestration,

80 Inhibition of protein prenylation represents a mechanism of oAbeta(42)

81 retreatment with lovastatin, an inhibitor of protein prenylation, resulted in superinduction of NOS-2

82 Exogenous farnesol, which enhances membrane protein prenylation, reversed viperin-mediated inhibitio

83 poptotic cell death induced by inhibitors of protein prenylation such as bisphosphonates.

84 tatins are caused primarily through impaired protein prenylation that results in mitochondria dysfunc

85 cific inhibitors, the relative importance of protein prenylation versus terminal cholesterol synthesi

86 ailability of the intermediates required for protein prenylation was responsible for decreased gammah

87 o the unprenylated form of RaplA, effects on protein prenylation were assessed by Western blot analys

88 of senescent human fibroblasts by inhibiting protein prenylation, without affecting the senescent gro

89 doubts about whether any treatment targeting protein prenylation would be particularly effective.