ライフサイエンスコーパス: protein processing

1 es a new paradigm for cellular regulation of protein processing.

2 heterologous cells, reflects loss of normal protein processing.

3 f the wild-type I7 protein in trans restored protein processing.

4 a major defect in viral translation or viral protein processing.

5 , Env, and genomic RNA incorporation and Gag protein processing.

6 n motifs implicated in vesicle transport and protein processing.

7 sly unrecognized importance in polyglutamine protein processing.

8 ltransferase involved in post-isoprenylation protein processing.

9 nt with a role for the pwi/WRB protein in TA-protein processing.

10 l of the replication, protein synthesis, and protein processing.

11 essary for initiation of translation and for protein processing.

12 udding, Gag-Pol and genome incorporation, or protein processing.

13 d by catalytic activity, mRNA induction, and protein processing.

14 recursor protein are important in regulating protein processing.

15 in E function, and altered amyloid precursor protein processing.

16 t gamma-secretase, on beta-amyloid precursor protein processing.

17 ses an impairment of protein degradation and protein processing.

18 spectively, with viral replication and viral protein processing.

19 s and genes involved in lipid metabolism and protein processing.

20 mic reticulum (ER) is intimately involved in protein processing.

21 negative regulator of the amyloid precursor protein processing.

22 to affect virus particle production and Gag protein processing.

23 that regulates vital cellular functions and protein-processing.

24 or a Smo-agonist-induced inhibition of Gli3 protein processing, a known in vivo indicator of Hh sign

25 t GSK-3 alpha may regulate amyloid precursor protein processing and Abeta formation.

26 led with reduced levels of amyloid precursor protein processing and Abeta production, compared with t

27 with IVA, which lead to abnormalities in IVD protein processing and activity.

28 rther understanding of mechanisms regulating protein processing and aggregation, as well as of the to

29 proteins during the whole lifetime; abnormal protein processing and aggregation; and cellular toxic e

30 ritical relevance in disparate areas such as protein processing and beta-amyloid and prion behavior.

31 ependent gamma-glutamyl carboxylation during protein processing and block the secretion of under-gamm

32 (32) mutants exhibited stable IN and RT, and protein processing and cDNA production were unaffected.

33 fusion, although still allowing efficient F-protein processing and cell surface transport.

34 tive extracellular matrix assembly to faulty protein processing and cellular trafficking caused by ge

35 n contributions of N-linked glycosylation to protein processing and correct disulfide bond formation,

36 nts, suggesting a unique role of VPEgamma in protein processing and degradation in Arabidopsis.

37 it suggests a role for hBH in intracellular protein processing and degradation.

38 se results suggest that slower nonstructural protein processing and delayed 26S RNA synthesis in wild

39 Furthermore, scaffolding protein processing and DNA encapsidation were inhibited

40 d number of animals, evidence of abnormal ER protein processing and dysregulation of translational co

41 the importance of the maintenance of proper protein processing and folding as a partial antidote to

42 We examined cellular protein processing and functional expression of photorec

43 pression mimicked the I3C inhibition of CD40 protein processing and G(1) cell cycle arrest, whereas s

44 nd 11, two enzymes involved in both cytokine protein processing and induction of apoptosis, were redu

45 hat the protein does not have a role in seed protein processing and maturation.

46 Abnormal protein processing and modification is associated with A

47 -Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this org

48 results offer unexpected insights into viral protein processing and pathogenesis that may be applicab

49 nses ranging from intracellular signaling to protein processing and presentation.

50 transcriptional mechanisms involving altered protein processing and rapid turnover exist to limit E-c

51 CF-causing mutation and results in defective protein processing and reduced CFTR function, leading to

52 e folding defect, which disrupted ovine CFTR protein processing and reduced membrane stability.

53 lon2 defects in auxin metabolism and matrix protein processing and rescued the abnormally large size

54 case, proteins related to amyloid precursor protein processing and secretion are S-nitrosated, corre

55 ed regarding the mechanisms that control Wnt protein processing and secretion from cells, transport t

56 owever, genes whose products are involved in protein processing and secretion were not highly regulat

57 Among these are proteins with key roles in protein processing and secretion, such as calreticulin,

58 -terminal sequences of LFNG, which allow for protein processing and secretion, with the N-terminus of

59 at rapid LFNG turnover could be regulated by protein processing and secretion.

60 cessing, mRNA half-life and translation, and protein processing and secretion.

61 ticulum (ER) stress that inhibits normal Wnt protein processing and secretion.

62 ns influence G551D-CFTR function, we studied protein processing and single-channel behaviour.

63 The W173G mutation affects protein processing and stability and results in severe m

64 Analysis of the protein processing and stability by metabolic pulse-chas

65 ns of PLP1 with CS1 and CS2 are critical for protein processing and suggest that the interactions pla

66 n regulating amyloidogenic amyloid precursor protein processing and support a model wherein Abeta pro

67 n this review is on the enzymology of prenyl protein processing and the functional significance of pr

68 beta-Amyloid precursor protein processing and the generation of Abeta have been

69 erase Pin1, which is able to regulate Notch3 protein processing and to stabilize the cleaved product,

70 This finding may have important roles in protein processing and trafficking in the Golgi as well

71 nk between the mitotic regulator, Lte1p, and protein processing and trafficking in the secretory/endo

72 ould be useful for numerous other studies on protein processing and transport.

73 hat blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of

74 g phenotype, we show that the effects on Gag protein processing and virus particle production of both

75 CS2, but not at CS1, and results in altered protein processing and virus replication.

76 irs severely channel gating without altering protein processing and which affects a residue in the sa

77 mutations in GALC can cause GLD by impairing protein processing and/or folding and that pharmacologic

78 s suggested that mutations negatively affect protein processing and/or function, and a bmp9-deficient

79 Proteases, which are involved in an array of protein-processing and intracellular signaling events in

80 ence with farnesyltransferase function ( ie, protein processing), and blockade of signal transduction

81 -Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Ab

82 ding inflammation, oxidative stress, altered protein processing, and decreased mitochondrial function

83 machinery, protein trafficking, constitutive protein processing, and immune function.

84 n expression pattern, apparent regulation of protein processing, and mesoderm-inducing activity suppo

85 rch has been focused on the gene expression, protein processing, and mutations of MYOC/TIGR, which is

86 g neuropeptide metabolism, amyloid precursor protein processing, and neuronal apoptosis are up-regula

87 n implicated in learning and memory, amyloid protein processing, and neuronal plasticity.

88 FTR function, Pro205 is critical for correct protein processing, and Pro99 may contribute either dire

89 e at nsP1 538 on viral growth, nonstructural protein processing, and RNA synthesis.

90 onal relationship between membrane topology, protein processing, and subcellular distribution, and su

91 unction in transcription, energy production, protein processing, and the upregulation of cyclophilin

92 tide metabolism, DNA replication and repair, protein processing, and virion structure.

93 Although amyloid precursor protein processing appeared unaffected, we find that LPS

94 if issues related to Nodal transcription and protein processing are not considered.

95 The mechanisms that couple translation and protein processing are poorly understood in higher eukar

96 ation-induced defects in anchor assembly and protein processing are rapid, and occur without altered

97 hesized to perform a unique function in seed protein processing, but we demonstrated previously that

98 Inhibition of protein processing by ER stress (ionomycin and dithiothr

99 nto the molecular elements that regulate Gli protein processing by the proteasome.

100 n eeyarestatin I, and specifically inhibited protein processing by the ubiquitin-proteasome system.

101 Foamy virus Pol precursor protein processing by the viral protease occurs at only

102 CAAX-box protein processing can be an important part of host-path

103 Rescue of ER protein processing capacity by the combined action of UP

104 Instead, the lesion was in the protein processing capacity of the ER lumen, where p58(I

105 at demand for ER membrane is integrated with protein processing capacity was initially suggested by g

106 n distinct proteolytic systems for precursor protein processing catalyzed by the mitochondrial and st

107 Increased APP (amyloid precursor protein) processing causes beta-amyloid (Abeta) accumula

108 calization were characterized by analysis of protein processing, cDNA production, genomic RNA protect

109 tivity support the hypothesis that localized protein processing controls production of a dorsal mesod

110 i) sORF peptides trigger proteasome-mediated protein processing, converting the Shavenbaby (Svb) tran

111 ded with the increased auxin sensitivity and protein processing correlated with the manifestation of

112 However, inhibition of K-RasB protein-processing could not be detected.

113 Suppression of translation relative to ER protein processing (cycloheximide) produced approximatel

114 To identify compounds that could inhibit protein processing dependent on the HERV-K10 protease, a

115 nated archaeosortase A (ArtA), as the likely protein-processing enzyme for PGF-CTERM.

116 ngs contain high levels of amyloid precursor protein processing enzymes (BACE1 and presenilin 2) and

117 mmodate the difference in specificity of the protein-processing enzymes of procaryotes.

118 ated superfamily of deeply membrane-embedded protein-processing enzymes.

119 These results demonstrate how one protein-processing event can activate latent protease re

120 ptional activation domain, is generated by a protein-processing event.

121 iption isoform is generated through a unique protein-processing event.

122 NRG-2 antibodies were generated to analyze protein processing, expression, and subcellular distribu

123 Although many UPR-regulated genes encode ER protein processing factors, others, such as those encodi

124 zed into four groups: transcription factors, protein processing factors, RNA-binding proteins, and pl

125 Cellular channel protein processing fails in every one of the non-functio

126 angles as well as aberrant amyloid precursor protein processing found in AD.

127 CA3 region and a switch in amyloid precursor protein processing from non-amyloidogenic to amyloidogen

128 otide polymorphisms at pre-mRNA splicing and protein processing/functional levels.

129 , including one which contains four CAAX-box protein processing genes.

130 rough different mechanisms to interfere with protein processing (i.e., tunicamycin, brefeldin A, and

131 However, the role of post-isoprenylation protein processing in ABA signal transduction has not be

132 hances the understanding of alpha-crystallin protein processing in aging and diseased human lenses.

133 an essential role for peptide deformylase in protein processing in all plant plastids.

134 we demonstrated previously that Asn-specific protein processing in developing Arabidopsis seeds occur

135 s, tyrosinase (TYR) and Pmel17, to elucidate protein processing in early or late steps of the secreto

136 gnificant downregulation of genes related to protein processing in endoplasmic reticulum, as well as

137 Akt signaling pathway, hemoglobin chaperone, protein processing in endoplasmic reticulum, detoxificat

138 tarch and sucrose metabolism, RNA transport, protein processing in endoplasmic reticulum, etc.

139 in family of proteins, suggesting a role for protein processing in limb, cardiac and reproductive sys

140 ns revealed pervasive, functionally relevant protein processing in normal and diseased tissue-from 40

141 We investigated POMC expression and protein processing in normal human keratinocytes.

142 portant aspects of postendoplasmic reticulum protein processing in plants.

143 The lack of understanding of the protein processing in silk glands has prevented the reca

144 eterminant domain, functions as a signal for protein processing in the context of not only Gli2 and G

145 ysiological importance of GADD34 turnover in protein processing in the endoplasmic reticulum and the

146 ed cells suggest that torsinA contributes to protein processing in the secretory pathway, endocytosis

147 systems suggests that mutant torsinA alters protein processing in the secretory pathway.

148 isease mutations underlying PNKD may disrupt protein processing in vivo, a hypothesis supported by ou

149 lesterol synthesis affects amyloid precursor protein processing in vivo, we crossed cholesterol 24-hy

150 ed methodologies permit in vitro and in vivo protein processing in ways previously not possible using

151 s in GALC activity and a lack of appropriate protein processing into an N-terminal GALC fragment for

152 Since nonstructural protein processing is known to regulate alphavirus RNA s

153 We found that the terminal protein processing is most likely a consequence of the i

154 exocytic vesicles are properly generated and protein processing is normal in the exo70 mutants.

155 t function in glycolysis, transcription, and protein processing is not affected in kcs1Delta.

156 The role(s) of specific proteases in seed protein processing is only vaguely understood; indeed, t

157 hether the requirement for the RCE1-mediated protein processing is related to the absence of the endo

158 indicate that the intracellular site of CAAX protein processing is the ER membrane, presumably on its

159 us, some aspect of translation or subsequent protein processing leads to non-functional or absent ACh

160 f nsp3 as a conserved component of the viral protein processing machinery, which is intimately associ

161 ar mechanism of the defect likely relates to protein processing, metabolic turnover rate, or transloc

162 e functionally involved in amyloid precursor protein processing, notch receptor signaling, and progra

163 ight be regulated, we examined intracellular protein processing of each subunit.

164 e temporal relationship between LOX mRNA and protein, processing of LOXL1 protein, FBLN5 and tropoela

165 lnerability to other insults due to abnormal protein processing or changes in signaling pathways whic

166 ithout detectably altering amyloid precursor protein processing or extracellular Abeta/beta-amyloid b

167 viruses showed no apparent alteration to Gag protein processing or reduction in the yield of virions

168 ic reticulum GTPases that may be involved in protein processing or trafficking.

169 eceptor downmodulation, signal transduction, protein processing or translocation, protein-protein int

170 ion but do not affect reverse transcription, protein processing, or catalytic activity in vitro.

171 n regulating cellular stress associated with protein-processing pathologies.

172 The additional modifications in the prenyl protein processing pathway also affected the interaction

173 ological reasons, including probing the CaaX protein processing pathway.

174 t furin is involved in at least two separate protein processing pathways that each contribute to the

175 array analysis showed that genes involved in protein processing pathways that were germane to the act

176 are suggestive of a role for cotranslational protein-processing pathways in maintaining epithelial lu

177 These results confirm the predicted protein processing pattern for mature SARS-CoV replicase

178 nts were analyzed and shown to have restored protein processing phenotypes in vivo.

179 However, despite the impact on seed protein processing, plants devoid of all known functiona

180 no acids in short linear motifs (SLiMs), and protein processing promote multifunctional behaviour.

181 r of the Kex2/furin family of eukaryotic pro-protein processing proteases, which cleave sites consist

182 he NS proteins include enzymes necessary for protein processing (proteases) and viral replication (RN

183 s a major role in endoplasmic reticulum (ER) protein processing, protein quality control, maintaining

184 l important aspects including NT/N precursor protein processing, ratios of different NT/N mRNA isofor

185 The many protein processing reactions of the ATP-hydrolyzing Hsp7

186 improved product purification or maximizing protein processing, remain areas for novel vector and ho

187 uscle, is unique to ALS, dysregulation of ER protein processing, responsible for correct protein fold

188 these proteins are known to be necessary for protein processing, reverse transcription, and integrati

189 potential roles for the IN CTD in precursor protein processing, reverse transcription, integration,

190 a variety of drug treatments known to affect protein processing similarly reduced Abeta release from

191 deficiency did not affect amyloid precursor protein processing, soluble Abeta oligomer levels, Abeta

192 Ca(2+) is required for protein processing, sorting, and secretion in eukaryotic

193 ucleotide mutation of this gene that affects protein processing, stability, and function.

194 used to illustrate the complete sequence of protein processing steps available with the platform.

195 show that a complete integrated sequence of protein processing steps can be performed on this platfo

196 dergoes several critical cell-mediated viral protein processing steps, including unfolding and cleava

197 tion in receptor binding but not in envelope protein processing, suggesting that addition of the GFP

198 in phospholipid biosynthesis, transcription, protein processing/synthesis, and protein trafficking.

199 N-Linked glycosylation is a common form of protein processing that can profoundly affect protein ex

200 , despite these differences in intracellular protein processing, the T cell and antibody responses ge

201 s suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defecti

202 pt for the absence of A19 and decreased core protein processing, they appeared to have a similar prot

203 ferentiation and has also been implicated in protein processing through its interaction with the ER c

204 Brefeldin A and monensin, inhibitors of protein processing through the Golgi, both blocked the 8

205 e SREBP-1 (sterol regulatory element-binding protein) processing through the conventional cholesterol

206 t on Gli3 by regulating the full-length Gli3 protein processing to generate a Gli3 repressor gradient

207 y dependent on exogenously added trypsin for protein processing to release the HA2 fusion peptide.

208 an engineered-enzyme that may be useful as a protein processing tool.

209 teasome system (UPS) is a major regulator of protein processing, trafficking, and degradation.

210 scription and modification, DNA replication, protein processing, virion assembly, and virion structur

211 sis, nucleotide metabolism, DNA replication, protein processing, virion structure and assembly, and v

212 Inhibition of H-Ras, N-Ras, and lamin B protein processing was observed at concentrations of R11

213 correct biochemical step (I7L-mediated core protein processing) was being inhibited.

214 To analyze env protein processing, we used the herpes simplex virus pro

215 the hydrophobic core that prevented envelope protein processing were also found.

216 375, and each was shown to restore envelope protein processing when combined with the C-terminal 81T

217 that of HIV-1 generated a virus with normal protein processing which could package the HIV-1-based v

218 viral particles in spite of normal envelope protein processing, wild-type levels of cell surface exp

219 We identify conditions allowing efficient protein processing with high peptide yields and demonstr

220 P in coordinating endoplasmic reticular (ER) protein processing with mRNA translation was examined in

221 Aberrant protein processing with tissue deposition is associated