ライフサイエンスコーパス: protein secretion

1 heir receptor site on SecA are essential for protein secretion.

2 n the cytoplasm before chaperone binding and protein secretion.

3 three nonstructural proteins also inhibited protein secretion.

4 e layer as a model system for studying plant protein secretion.

5 different point mutations generally affected protein secretion.

6 er, this did not result in the inhibition of protein secretion.

7 they are unexpectedly involved in modulating protein secretion.

8 1-induced reduction of both HGF mRNA and HGF protein secretion.

9 is essential for autophagy, endocytosis and protein secretion.

10 ion as an autocrine factor to stimulate tear protein secretion.

11 s, for example, from an increased demand for protein secretion.

12 on occurs distant from the site of precursor protein secretion.

13 cylation is a novel mechanism that regulates protein secretion.

14 m-independent mechanism for lacritin-induced protein secretion.

15 or 2BC in COS-1 cells strongly inhibits host protein secretion.

16 to poliovirus-induced inhibition of cellular protein secretion.

17 ead to defining its novel role in regulating protein secretion.

18 to increase [Ca(2+)](i) but not to stimulate protein secretion.

19 to increase [Ca(2+)](i) but not to stimulate protein secretion.

20 hion to potently silence gene expression and protein secretion.

21 overexpression of SEL1L efficiently improves protein secretion.

22 exes involved in multidrug efflux and type I protein secretion.

23 haperones, ensures the hierarchy in type III protein secretion.

24 d between trophic factor mRNA expression and protein secretion.

25 acrimal gland and to determine their role in protein secretion.

26 omerular podocytes; both displayed increased protein secretion.

27 to stimulate an increase in [Ca(2+)](i) and protein secretion.

28 mechanisms to increase [Ca(2+)](i) and cause protein secretion.

29 lates P2X7 receptors to increase [Ca2+]i and protein secretion.

30 ways not used by P2X7 receptors to stimulate protein secretion.

31 -associated protein degradation, and reduced protein secretion.

32 ink between staphylococcal cell division and protein secretion.

33 expression of miR-93 in cells abrogated VEGF protein secretion.

34 n of actin filaments has a general effect on protein secretion.

35 splenocyte cultures reduced IL-17F mRNA and protein secretion.

36 types that may also be related to defects in protein secretion.

37 ceptor-mediated activation of unconventional protein secretion.

38 f metabolism via its modulation of adipocyte protein secretion.

39 tivation or IL-1beta treatment increased NGF protein secretion.

40 the exoproteome showed that Slr1270 mediates protein secretion.

41 tersects sites involved in glycosylation and protein secretion.

42 gesting an inhibitory effect of mutations on protein secretion.

43 ve to construct efficient cell factories for protein secretion.

44 not been identified before in the context of protein secretion.

45 ereas p38 inhibition had no effect on IL-17C protein secretion.

46 hrough up-regulating TSLP mRNA expression or protein secretion.

47 de a unique system for the analysis of plant protein secretion.

48 em is the major protein-biogenic pathway for protein secretion across the cytoplasmic membrane or ins

49 s is the first in vitro system for analyzing protein secretion across the outer membrane of gram-nega

50 ve shown that type IV pili are important for protein secretion across the outer membrane, similar to

51 s similar in sequence to GldN, has a role in protein secretion across the outer membrane.

52 flammatory cytokine mRNA levels and cytokine protein secretion activities.

53 d (ii) In conjunction with PscO, it controls protein secretion activity by modulating the ability of

54 markedly enhanced soluble amyloid precursor protein secretion (alphaAPPs), alpha-secretase, and PKCa

55 reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions.

56 Osmotic support restores GPI protein secretion and actin polarization but not growth.

57 vestigation of the contributions of PrsA2 to protein secretion and activity as well as to bacterial v

58 viruses are needed that fail to inhibit host protein secretion and also exhibit robust growth propert

59 roles in ER stress-associated unconventional protein secretion and are potential therapeutic targets

60 s one of the best characterized pathways for protein secretion and assembly of cell surface appendage

61 D2 adenovirus, also increased Cch-stimulated protein secretion and decreased ERK activity.

62 1-Butanol increased Cch-stimulated protein secretion and decreased ERK activity.

63 ew integrates new information about the role protein secretion and detection and production of ions a

64 The requirement of functional Slr1270 for protein secretion and drug resistance mechanisms suggest

65 at loss of Tango1, in addition to disrupting protein secretion and ER/Golgi morphology, causes ER str

66 RNA decoding, mRNA biogenesis/stability, and protein secretion and folding.

67 ammalian posttranslational pathway for small-protein secretion and identify an unexpected role for ca

68 gulation of CANT1 is associated with reduced protein secretion and increased degradation rates.

69 tural barrier that requires modification for protein secretion and large-molecule transport as well a

70 Protein secretion and localization are crucial during eu

71 bioactive species and lead to unconventional protein secretion and lytic cell death.

72 protein-channel component of the ubiquitous protein secretion and membrane protein insertion apparat

73 Relative to the wild type, deficiency of protein secretion and membrane protein insertion machine

74 ur data showed a significant increase of MIF protein secretion and mRNA expression in endometriotic c

75 embly process, as well as for studying other protein secretion and organelle biogenesis systems.

76 ct with other partner proteins to accomplish protein secretion and outer membrane protein assembly.

77 This study explored the relationship between protein secretion and pilus formation in Vibrio cholerae

78 of the S. pyogenes membrane, specialized for protein secretion and processing.

79 family proteins may play important roles in protein secretion and that the UPR may contribute to the

80 trating that Xps T2S is required for optimal protein secretion and the detrimental effects on host ce

81 nergic agonists use the PLD pathway to alter protein secretion and to identify the molecular signalin

82 ocator proteins EspB, EspD, and EspA mediate protein secretion and translocation from wild-type enter

83 offers unexpected mechanisms for modulating protein secretion and/or endosome recycling events at th

84 bacterial holo-translocon (HTL), capable of protein-secretion and membrane-protein insertion.

85 increase in levels of MMP-10 messenger RNA, protein secretion, and activity.

86 ficant reduction in LEE expression, effector protein secretion, and attaching and effacing (A/E) lesi

87 ited Cch-stimulated PLD1 activity, increased protein secretion, and decreased ERK activity.

88 nd and when stimulated increase [Ca(2+)](i), protein secretion, and ERK 1/2 activation.

89 virulence genes involved in iron metabolism, protein secretion, and glycosylation, which was leverage

90 TGF-beta promoter activity, reduced TGF-beta protein secretion, and inhibited TGF-beta-induced Smad2-

91 both Lep transcript accumulation and leptin protein secretion, and may play a role in the sexual dim

92 rdinated activities of host cell attachment, protein secretion, and motility by the parasite.

93 l for formation of the epithelium, polarized protein secretion, and proper multicellular morphogenesi

94 ily responsible for maintaining cell growth, protein secretion, and recovery from a reductive challen

95 the recruitment of COPII components, general protein secretion, and retrograde transport of the KDEL-

96 or pseudopilus length control, essential for protein secretion, and supports the Archimedes screw mod

97 ortant for cells, which are highly active in protein secretion, and that breakdown of this regulatory

98 ocesses such as cell migration and adhesion, protein secretion, and/or gene transcription.

99 A novel protein secretion apparatus called the Por secretion sys

100 lly, multiple virulent toxins from bacterial protein secretions are concurrently and naturally entrap

101 um-resident genes required for antimicrobial protein secretion as markers, we identified a heat-shock

102 ne-treated acinar cells, lacritin stimulated protein secretion as much as that in normal cells.

103 ates will contribute to our understanding of protein secretion as part of host-microbiome interaction

104 ults support a role for this gene product in protein secretion as well as in pili formation.

105 Compared to the state-of-the-art protein secretion assay such as ELISpot and emerging mic

106 In antibiotic sensitivity and protein secretion assays, CsgG expression alone allowed

107 ancreatic beta cells have one of the highest protein secretion burdens in the body, as these cells mu

108 ne synthases--impaired biofilm formation and protein secretion but not cell viability.

109 hagy gene Atg1 is required for autophagy and protein secretion, but it is not required for endocytosi

110 n prostate cancer cells, myosin VI regulates protein secretion, but the overexpression of myosin VI h

111 hanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic s

112 likely caused by defects in collagen matrix protein secretion by costal chondrocytes.

113 s in up-regulation of C3 gene expression and protein secretion by HepG2 cells.

114 tein (oxLDL) increase C3 gene expression and protein secretion by human macrophages.

115 carotid endarterectomies and an analysis of protein secretion by lipid-loaded human vascular smooth

116 es and plays an important role in regulating protein secretion by pancreatic acinar cells, as does Ra

117 The mechanisms of protein secretion by pathogenic bacteria remain poorly u

118 To gain a better understanding of protein secretion by roots, we conducted a systematic pr

119 vation of proIL-1beta and for unconventional protein secretion by skin-derived keratinocytes.

120 Here we show that protein secretion by the type VI secretion system of Vib

121 This work highlights how regulated protein secretion can synergize with tissue movement to

122 here is increasing interest in improving its protein secretion capacity.

123 s neuronally expressed calcium activator for protein secretion (CAPS) homolog unc-31.

124 imply that CsgG is an ungated, non-selective protein secretion channel that is expected to employ a d

125 m for hierarchical trafficking regulation in protein secretion channels.

126 ilus assembly is homologous with the type II protein secretion complex.

127 alpha proximal promoter leading to increased protein secretion, confirming a pivotal role for NF-kapp

128 BiP cleavage in HepG2 hepatoma cells, (glyco)protein secretion continues unabated in SubAB-exposed He

129 rtment called compartment for unconventional protein secretion (CUPS).

130 whereas TNFalpha-mediated stimulation of C3 protein secretion depends on activation of MEK1/2, p38,

131 In biological membranes, various protein secretion devices function as nanomachines, and

132 ated up-regulation of C3 gene expression and protein secretion due to interference with NF-kappaB via

133 its components, encoded by the extracellular protein secretion (eps) genes.

134 leukin 6 (IL-6) and IL-8 mRNA expression and protein secretion from A549 lung epithelial cells.

135 c DSS model and impeded ex vivo pro-fibrotic protein secretion from stenotic CD biopsies.

136 In cell lines, TFG inhibition slows protein secretion from the endoplasmic reticulum (ER) an

137 date on the processes that mediate selective protein secretion from within eosinophil granules both a

138 Protein secretions from individual cells create spatiall

139 yte concentration, such as those produced by protein secretions from live cells.

140 Cell viability and serum protein secretion functions were assessed.

141 ons, but some fundamental processes, such as protein secretion, have been difficult to engineer using

142 ATP increased [Ca(2+)](i) and protein secretion in a concentration-dependent manner.

143 nd increased adiponectin gene expression and protein secretion in a dose-dependent manner.

144 able chemical biology tools for the study of protein secretion in a wide variety of different bacteri

145 stimulated Vegf messenger RNA expression and protein secretion in ChECs and RPE cells.

146 n tear glycoprotein that promotes basal tear protein secretion in cultured rat lacrimal acinar cells

147 The severe deficiency in alpha-hemolysin protein secretion in DeltafakA and DeltafakB1 DeltafakB2

148 ormal breast epithelial cells, induced IL-23 protein secretion in dendritic cells via induction of p1

149 ted PPARgamma; PgammaCA also induced Angptl4 protein secretion in ErbB2-transformed mammary epithelia

150 n turn activate MEK and ERK, which attenuate protein secretion in freshly isolated epithelial cells.

151 Perturbation of protein secretion in gibberellic acid-induced aleurone l

152 Protein secretion in Gram-negative bacteria is essential

153 16 on both Golgi apparatus fragmentation and protein secretion in HeLa cells.

154 The rate of protein secretion in host cells is inhibited during infe

155 tentiates LPS-induced C3 gene expression and protein secretion in macrophages, whereas oxLDL differen

156 periment was to investigate lacritin-induced protein secretion in normal and cytokine-pretreated (inf

157 onkey acinar cells, lacritin stimulated tear protein secretion in normal cells without elevating intr

158 ed by selective inhibitors to interfere with protein secretion in pathological settings.

159 Using a high-throughput assay for type III protein secretion in Salmonella enterica serovar Typhimu

160 uorescence and visible detection of type III protein secretion in Salmonella typhimurium.

161 functions as a facilitator of extracellular protein secretion in some Gram-negative bacterial pathog

162 P4 correlated with IL-10 gene expression and protein secretion in Th1 cultures.

163 ontributes to region-specific, age-dependent protein secretion in vitro.

164 ation, and KC (mouse IL-8) and IL-6 mRNA and protein secretion in wild-type mouse embryonic fibroblas

165 ukaryotic cells maintain strict control over protein secretion, in part by using the pH gradient main

166 uses have broader functions beyond flagellar protein secretion, including activation of essential two

167 vates robust vesicle-mediated unconventional protein secretion, including exosome release and membran

168 highly dedicated pathways for extracellular protein secretion, including the type II secretion (T2S)

169 residues serve as an allosteric modulator of protein secretion independent of its role in proteolysis

170 nd quantitative assay for analyzing type III protein secretion inhibitors.

171 vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and path

172 Protein secretion is a common property of pathogenic mic

173 Bacterial protein secretion is a highly orchestrated process that

174 The essential process of protein secretion is achieved by the ubiquitous Sec mach

175 Type III protein secretion is essential for many gram-negative ba

176 The inhibition of protein secretion is global, affecting the movement of a

177 MacE-induced Golgi modification showed that protein secretion is inhibited, with no effect on the ac

178 Thus, Mia3's role in protein secretion is much broader than previously realiz

179 These data suggest that protein secretion is required to maintain viability unde

180 A central event in protein secretion is the type I signal peptidase (SPase)

181 when mutant rdw-Tg (Tg-G2298R, defective for protein secretion) is co-expressed with wild-type Tg, th

182 e protein involved in drug efflux and type I protein secretion, is required for the virulence of the

183 ing substrate of the haemolysin co-regulated protein secretion island II T6SS (H2-T6SS).

184 es displaying significantly reduced effector protein secretion levels.

185 ucture and assembly of a broadly distributed protein secretion machine.

186 Curli formation requires a dedicated protein secretion machinery comprising the outer membran

187 Type III protein secretion machines have evolved to deliver bacte

188 ermore, an intact trehalose pathway controls protein secretion, mating, and cell wall integrity in C.

189 Differences in protein secretion may indicate that hES-RPE may not func

190 es made regarding mechanisms of conventional protein secretion, mechanistic insights into the unconve

191 Both IL-6 transcription and protein secretion mediated by alpha(1)-ARs were signific

192 molecular interactions in the regulation of protein secretion, membrane integration, and integral me

193 es, including host cell egress and invasion, protein secretion, motility and cell cycle regulation.

194 The bulk of bacterial protein secretion occurs through the conserved SecY tran

195 Protein secretion occurs via translocation by the evolut

196 ficient cultured eosinophils, had attenuated protein secretion of a subset of IL-33-induced genes, in

197 n beta-defensin (HBD)-2, HBD-3, and CAMP and protein secretion of HBD-2 and HBD-3.

198 reased palmitate-induced mRNA expression and protein secretion of IL-6 and IL-1beta.

199 roliferation but induced mRNA expression and protein secretion of interferon (IFN)-gamma and interleu

200 caspase-1 activity regulates unconventional protein secretion of many other proteins involved in inf

201 We characterize the fluctuations in protein secretion of single cells, and of small cell col

202 a and IL-1beta increased mRNA production and protein secretion of the neutrophil chemotactic CXCL1, C

203 versus Cox2 KO BMMs, and RANKL induced Saa3 protein secretion only from WT BMMs.

204 t growth, but they have no apparent roles in protein secretion or endocytosis.

205 placental apoptosis, necrosis, alteration in protein secretion, or increased transcription.

206 The ExPortal protein secretion organelle in Streptococcus pyogenes is

207 thway has been identified as the most common protein secretion pathway among Gram-negative bacteria.

208 Autotransporter (AT) is a protein secretion pathway found in Gram-negative bacteri

209 t SOD1 has a substantial impact on astrocyte protein secretion pathways, contributing to motor neuron

210 retion system effector Hcp1, suggesting that protein secretion play a role colonisation in rice.

211 h carbon sugar transport and utilization and protein secretion, potentially indicating that Endozoico

212 cell adhesion proteins and a highly dynamic protein secretion process.

213 Mutation of PA1303 resulted in an altered protein secretion profile and increased N-butanoyl homos

214 gy was used for assessing differences in the protein secretion profile of ACT made with collagen scaf

215 ial connective tissue (AACT) had a different protein secretion profile to that of clot-embedded AACT.

216 tegrates microfluidic cell handling, in situ protein secretion profiling, and information theory to d

217 rgJ that specifically alter the hierarchy of protein secretion provides additional support for a comp

218 n about how individual cells may alter their protein secretion rates on the timescale of minutes or s

219 Eukaryotic protein secretion requires efficient and accurate delive

220 racellular clusterin and decreased clusterin protein secretion, resulting in the p53-dependent induct

221 tial roles for mucin-type O-glycosylation in protein secretion, stability, processing, and function.

222 icient pseudopilus assembly is essential for protein secretion, structure-based functional analyses a

223 eased proinflammatory cytokines depress tear protein secretion, suggesting that a decline in lacrimal

224 genome of Q8r1-96 and identified a type III protein secretion system (T3SS) gene cluster that has ov

225 Type VI protein secretion system (T6SS) is important for bacteri

226 The type VII protein secretion system (T7SS) plays a critical role in

227 gen Pseudomonas syringae requires a type-III protein secretion system and the effector proteins it in

228 tures with the previously described type III protein secretion system effector ILEs and are considere

229 virulence mechanisms, including the type VII protein secretion system ESX-1, biosynthesis of polyketi

230 considerably advance knowledge of the plant protein secretion system in general and emphasize the ve

231 In this model, the protein secretion system of insulin-producing pancreatic

232 nd ChiX operate in tandem as components of a protein secretion system used by gram-negative bacteria.

233 rect or indirect restriction of the type III protein secretion system's (T3SS) ability to inject type

234 O, which encode components of a bacteroidete protein secretion system, blocked the transport of RemA

235 The Type VII protein secretion system, found in Gram-positive bacteri

236 Recently, a novel protein secretion system, the Por secretion system (PorS

237 A novel protein secretion system, the type IX secretion system (

238 A novel protein secretion system, the type IX secretion system (

239 imers, to engineer the first light-triggered protein secretion system.

240 is injected into plant cells by the type III protein secretion system.

241 Type III protein secretion systems (T3SSs), which have evolved to

242 rmation for further understanding chlamydial protein secretion systems and modeling COMC and EB struc

243 Type III protein secretion systems are being considered for vacci

244 hylum Bacteroidetes, suggesting that similar protein secretion systems are common among members of th

245 Protein secretion systems are critical to bacterial viru

246 Type III protein secretion systems are unique bacterial nanomachi

247 e that GBPs detect the presence of bacterial protein secretion systems as "patterns of pathogenesis"

248 Bacterial type III protein secretion systems deliver effector proteins into

249 Mycobacteria use the dedicated type VII protein secretion systems ESX-1 and ESX-5 to secrete vir

250 Type III protein secretion systems have specifically evolved to d

251 Protein secretion systems in Gram-negative bacteria evol

252 ponents of multidrug efflux pumps and type I protein secretion systems of gram-negative bacteria.

253 SRE encode all six known protein secretion systems present in gram-negative bacte

254 ly secretory antigen target 6 kDa secretion) protein secretion systems require FtsK/SpoIIIE family AT

255 hogens use at least 6 distinct extracellular protein secretion systems to export proteins through the

256 Bacteria utilise specialised protein secretion systems to interact with host organism

257 Genes associated with other bacterial protein secretion systems were less common.

258 ce modifications but more genes for Sec-like protein secretion systems, anaplerotic CO(2) incorporati

259 Its virulence depends on protein secretion systems, in particular, the Dot/Icm ty

260 enesis pathway is one of the best-understood protein secretion systems, thanks largely to innovative

261 Among protein secretion systems, there are specialized ATPases

262 Hemin binding proteins, secretion systems, response regulators, and ge

263 . pneumophila (lspF) mutants lacking type II protein secretion (T2S) are also impaired for a surfacta

264 Type II protein secretion (T2S) by Legionella pneumophila is req

265 o be sequenced, encodes a functional type II protein secretion (T2S) system.

266 ureus secrete virulence factors via type VII protein secretion (T7S), a system that intriguingly requ

267 that establish a threshold for the level of protein secretion that can be induced by LPS stimulation

268 sA2 and HtrA, the increase in PrfA-dependent protein secretion that occurs following bacterial entry

269 icant increase in Shh gene transcription and protein secretion that was dependent on BBS-induced GPCR

270 mixture of reacting glandular metabolite and protein secretions that provides critical support functi

271 Notably, protein secretion through the curli export pathway facil

272 rG (residues 52-73) is important in blocking protein secretion through the T3SS.

273 -LcrV interaction is important in regulating protein secretion through the T3SS.

274 ulators lasR and rhlR, and genes involved in protein secretion, translation, and response to oxidativ

275 Protein secretion typically involves translocation of un

276 Chemical control of protein secretion using a small molecule approach provid

277 contact with enterocytes induces a burst of protein secretion via its type III secretion apparatus (

278 sed as a secretion signal to direct selected protein secretion via the flagellar type III secretion (

279 nd the human huntingtin protein to show that protein secretion via this specialized export pathway pr

280 was less than additive, but the increase in protein secretion was additive.

281 sperm storage) continued when only canonical protein secretion was compromised in adult glands.

282 Unconventional protein secretion was followed by cell necrosis and NLRP

283 eta, TNF, and IL-4 production, whereas IL-10 protein secretion was increased.

284 Protein secretion was induced by lacritin or carbachol (

285 Protein secretion was measured by fluorescence assay.

286 t analysis was performed for 20 minutes, and protein secretion was measured spectrophotometrically.

287 Protein secretion was measured with a fluorescence assay

288 Protein secretion was measured with ELISAs and multiplex

289 hES-RPE and fRPE protein secretion was similar on equatorial BM except fo

290 Peroxidase secretion, our index for protein secretion, was measured spectrophotometrically.

291 LCB on adiponectin and leptin expression and protein secretion were also investigated.

292 IL-6, IL-8, and CXCL12 mRNA expression and protein secretion were evaluated by quantitative polymer

293 sA2 and PrsA1 to L. monocytogenes growth and protein secretion were investigated in vitro and in vivo

294 la cells, and Mbnl-dependent translation and protein secretion were observed for a subset of mRNAs wi

295 involved in vesicle-mediated trafficking and protein secretion were required to prevent spontaneous a

296 tly decreased ATP-stimulated [Ca(2+)](i) and protein secretion, whereas the P2X(3) receptor agonist a

297 sed interleukin-6 (IL-6) mRNA expression and protein secretion, which is probably an important yet un

298 e/ouabain were not involved in activation of protein secretion, while dopamine-induced saliva contain

299 s highly stochastic, yielding variability in protein secretion, with E. coli cells undergoing divisio

300 This allele is predicted to prevent protein secretion without altering the activity of LFNG,