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1 r complex HOPS (homotypic fusion and vacuole protein sorting).
2 uitous clathrin adaptor AP-1A in basolateral protein sorting.
3 ansfer and lipid A synthesis and possibly by protein sorting.
4 propriate UNC-104 activity randomized axonal protein sorting.
5 ous cellular functions such as signaling and protein sorting.
6 d level of specificity in ubiquitin-mediated protein sorting.
7 ent with its previously reported function in protein sorting.
8 known function of the class C Vps complex in protein sorting.
9 rminus is vital for both voltage sensing and protein sorting.
10 th a particular focus on pathways regulating protein sorting.
11 a function of the BLOC-1 complex in membrane protein sorting.
12 disease-related defects in the regulation of protein sorting.
13 four ESCRT complexes in multivesicular body protein sorting.
14 for degradation by ubiquitination-dependent protein sorting.
15 be important for the function of the GGAs in protein sorting.
16 lecular mechanisms governing plasma membrane protein sorting.
17 domain proteins may be effectors of PI3P for protein sorting.
18 hip between raft association and subcellular protein sorting.
19 omain formation as a mechanism for endosomal protein sorting.
20 r these proteins in membrane trafficking and protein sorting.
21 is a model for the study of metal-regulated protein sorting.
23 11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) domain-containing proteins.
27 that all six HOPS subunits (Vps11 [vacuolar protein sorting 11]/CG32350, Vps18/Dor, Vps16A, Vps33A/C
28 amino acid substitutions in Vps13 (vacuolar protein sorting 13), a large universally conserved eukar
31 viously described ESCRT-I subunits (vacuolar protein sorting 23, -28, and -37), suggesting a distinct
33 the protein-trafficking regulators vacuolar protein sorting 33A protein (VPS33A) or cappuccino prote
36 class III phosphoinositide 3-kinase vacuolar protein sorting 34 (Vps34) plays a central role in modul
38 wn of the autophagy-specific genes, vacuolar protein sorting 34 (VPS34), and autophagy-related protei
39 sphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes results in aber
40 beclin 1 is a core component of the vacuolar protein sorting 34 (Vps34)/class III phosphatidylinosito
42 ion of PI3KC3-C1 consisting of VPS (vacuolar protein sorting) 34, VPS15, BECN1 (Beclin 1), and ATG (a
43 bulation and membrane association of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), a
45 P-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting 35 homolog), and M6PR (mannose 6-phospha
46 he retromer core component FgVps35 (Vacuolar Protein Sorting 35) in the cytoplasm as fast-moving punc
48 inclusion in microvesicles, whereas vacuolar protein sorting 4 (VPS4) mediates scission of microvesic
49 lopment, we identified an allele of Vacuolar protein sorting 4 (Vps4), which encodes an AAA ATPase th
51 ase activity of SKD1 (also known as Vacuolar Protein Sorting 4 or VPS4), a critical component require
52 als, the AAA ATPase Vps4p/SKD1 (for Vacuolar protein sorting 4/SUPPRESSOR OF K(+) TRANSPORT GROWTH DE
53 EGFR signaling by repressing Vps4b (vacuolar protein-sorting 4 homolog B), encoding a protein implica
55 nsport is likely to be regulated by vacuolar protein sorting 74 (Vps74p), a peripheral Golgi protein
57 also requires a histone chaperone, vacuolar protein sorting 75 (Vps75), as well as the major chapero
58 g protein C, fast type [MYBPC2] and vacuolar protein sorting 8 [VPS8], 2 families, 4.2%) or in anothe
59 dition of HOPS (homotypic fusion and vacuole protein sorting), a Ypt7p (Rab)-effector complex with a
60 e findings demonstrate that Erv26p acts as a protein sorting adaptor for a variety of Type II transme
63 specific mechanisms in terms of biogenesis, protein sorting and fate, which are far from completely
65 d biological membranes, although its role in protein sorting and membrane function still remains uncl
66 hinery that is normally involved in vacuolar protein sorting and multivesicular body (MVB) biogenesis
67 titative live cell imaging method to analyze protein sorting and post-Golgi vesicular trafficking.
70 ctyostelium, we demonstrate that WASH drives protein sorting and recycling from macropinosomes and is
71 d the shp1Delta mutation, implicated in both protein sorting and regulation of the Glc7p protein phos
72 ons block VPS4 recruitment, impair endosomal protein sorting and relieve dominant-negative VPS4 inhib
73 neration of functionally distinct membranes, protein sorting and the development of polarized differe
75 l cells are known, but when and how directed protein sorting and trafficking occur to initiate cell s
76 63-linked chains control ribosome function, protein sorting and trafficking, and endocytosis of memb
79 RT-II complex performs a central role in MVB protein sorting and vesicle formation, as it is recruite
82 e Vps-C complexes HOPS (homotypic fusion and protein sorting) and CORVET (class C core vacuole/endoso
84 ex termed HOPS (homotypic fusion and vacuole protein sorting), and soluble N-ethylmaleimide-sensitive
85 ESCRT-I/MVB12 subunits, Crag, a regulator of protein sorting, and bacterial pore-forming proteins mig
89 bind ubiquitylated proteins during vacuolar protein sorting, and probably many other biological proc
93 nally, we show that CHX17 and CHX20 affected protein sorting as measured by carboxypeptidase Y secret
94 equences of Arn1p were required for vacuolar protein sorting, as mutation of ubiquitinatable lysine r
96 other retromer components SNX-3 and vacuolar protein sorting-associated protein 35 (VPS-35) did not a
97 usceptibility protein domains and a vacuolar protein sorting-associated protein 9 with a coupling of
98 ons for signaling at cell-cell junctions and protein sorting at intracellular contact points between
100 scuss the implications of this mechanism for protein sorting at the exit sites of the Golgi and endop
103 tween Drs2p and the AP-1 clathrin adaptor in protein sorting at the TGN and early endosomes of Saccha
105 These results establish a role for active protein sorting at the trans-Golgi en route to the plasm
111 f plasma membrane proteins and receptors and protein sorting between the trans-Golgi network (TGN) an
112 tor proteins implicated in clathrin-mediated protein sorting between the trans-Golgi network and endo
113 in mouse erythroblasts, nor at the membrane protein-sorting boundary in human erythroblasts, which d
116 rough interactions with the class C vacuolar protein sorting (C-Vps) tethering complex and endosomal
117 mbrane fusion is essential for intracellular protein sorting, cell growth, hormone secretion, and neu
119 tosis/actin dynamics (SLA1, SLA2, and END3), protein sorting (class E vps), and vesicle-vacuole fusio
121 partner for the homotypic fusion and vacuole protein sorting complex (a master regulator of vacuole f
122 is enhanced by homotypic fusion and vacuole protein sorting complex (HOPS) and Sec17p/Sec18p, the va
123 8) and its effector homotypic fusion/vacuole protein sorting complex (HOPS) to (phago)lysosome membra
124 hering complex, homotypic fusion and vacuole protein sorting complex (HOPS), and phosphoinositides, w
125 ddition of pure homotypic fusion and vacuole protein sorting complex (HOPS), which bears the vacuolar
126 Pase Ypt7p, the homotypic fusion and vacuole protein sorting complex (HOPS)-VpsC Rab effector complex
130 -1, BLOC-2, and homotypic fusion and vacuole protein sorting complex subunits; clathrin; and phosphat
131 g complex HOPS (homotypic fusion and vacuole protein sorting complex), whereas the C-terminal SNARE m
133 vacuolar HOPS (homotypic fusion and vacuole protein sorting) complex in the yeast Saccharomyces cere
134 r4-Not complex, V-type ATPases, and vacuolar protein-sorting complexes as well as genes with unknown
136 e remodeling events that accompany endosomal protein sorting, cytokinesis, and enveloped RNA virus bu
137 rom the early endosomes (EE) requires active protein sorting decoded by a number of protein coats.
138 The mammalian homologue of yeast vacuolar protein sorting defective 34 (mVps34) has been implicate
141 1 and Vps4p and exhibits synthetic vacuolar protein sorting defects when combined with mutations in
143 uired for transport (ESCRT), which regulates protein sorting during endosomal trafficking, this assoc
144 y was undertaken to explore whether aberrant protein sorting, during enucleation, creates these membr
146 Endosomes function as a hub for multiple protein-sorting events, including retrograde transport t
147 propose that the principle of membrane-based protein sorting extends to monotopic membrane proteins,
149 r a synthetic yeast prion, we identified two protein-sorting factors of the Hook family, termed Btn2
151 thers have observed in class C VPS (vacuolar protein sorting) family mutants and morphants, and we re
152 nent of the cellular machinery that controls protein sorting from endosomes to lysosomes and speciali
154 hree complexes, termed BLOC-1 to -3, mediate protein sorting from the early endosome to lysosomes and
155 he thylakoid-transfer signal is required for protein sorting from the stroma to thylakoids, mainly vi
157 asolateral plasma membrane domains depend on protein sorting from the trans-Golgi network (TGN) and v
161 odes a homolog of the class C yeast vacuolar protein sorting gene, Vps33, that contains a Sec1-like d
162 mutants disrupted established VPS (vacuolar protein sorting) genes, The sixth, LTE1, is a Low Temper
166 a member of the homotypic fusion and vacuole protein sorting (HOPS) complex that delivers biosyntheti
167 the GTPase Rab7 and the homotypic fusion and protein sorting (HOPS) complex, but adaptor proteins tha
168 ntrolled by the homotypic fusion and vacuole protein sorting (HOPS) complex, rescued the neurotransmi
169 bunit tethering homotypic fusion and vacuole protein sorting (HOPS) complex, which is essential for t
173 he multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is req
174 ther, the Vps-C/homotypic fusion and vacuole protein sorting (HOPS) subunit Vps41, and a SNARE, Vam3.
175 uolar/lysosomal homotypic fusion and vacuole protein sorting (HOPS) tethering complex combines both a
177 lipids, and the homotypic fusion and vacuole protein sorting (HOPS)/class C Vps complex, an effector
178 it of the yeast homotypic fusion and vacuole protein-sorting (HOPS) complex, bound to two individual
180 members of the homotypic fusion and vacuole protein-sorting (HOPS) multisubunit tethering complex, w
181 c fusion and protein-sorting/class C vacuole protein-sorting (HOPS/class C Vps) complex can tether lo
184 that COP9-associated CSN5 regulates exosomal protein sorting in both a deubiquitinating activity-depe
187 nd mechanisms that regulate polarized apical protein sorting in hepatocytes, the major epithelial cel
188 trameric adaptor protein 1 (AP-1) complex in protein sorting in intracellular compartments is not yet
190 ptor protein (AP) complex family involved in protein sorting in the endomembrane system of eukaryotic
192 dressing fundamental questions, ranging from protein sorting in the photoreceptor cilium to photorece
195 roteins involved in endocytosis and vacuolar protein sorting including Hrs, Vps27p, Stam1, and Eps15
196 The Legionella pneumophila effector vacuolar protein sorting inhibitor protein D (VipD) localizes to
198 embranes requires host functions involved in protein sorting into late endosomal multivesicular bodie
200 wo-step kinetic and affinity-based model for protein sorting into the sequence-dependent recycling pa
201 ry should stimulate work on the mechanism of protein sorting into vesicles and the role of vesicles i
202 role of the yeast Nedd4 homologue, Rsp5, in protein sorting into vesicles that bud into the multives
204 Stn2 and favor a model according to which SV protein sorting is guarded by both cargo-specific mechan
207 protein to a specific destination (known as protein sorting) is a crucial event that is intrinsicall
208 ecessarily be a sole determinant in membrane protein sorting, its properties can markedly modulate th
209 nsporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not
210 plast proteins engage one of four additional protein sorting mechanisms that direct targeting to the
212 ed in these studies regulates cargo-specific protein sorting mediated by the epithelial cell specific
214 dc1(Ts) suppressors as class E vps (vacuolar protein sorting) mutants and shows that these, as well a
215 hat there are probably multiple pathways for protein sorting/MVB vesicle formation in human cells and
216 inds two isoforms of the retromer-associated protein sorting nexin 3 (SNX3), including a novel isofor
217 ave identified a novel intracellular adaptor protein, sorting nexin 17 (SNX17), that binds specifical
218 ave identified a unique rodent intracellular protein, sorting nexin 27 (SNX27), which regulates the t
219 The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have e
221 pon the functioning of the cellular vacuolar protein sorting pathway and reveal yet another facet of
222 the ESCRT proteins of the cellular vacuolar protein sorting pathway for efficient egress from the ce
225 y virus type 1 (HIV-1) exploits the vacuolar protein-sorting pathway by engaging Tsg101 and ALIX thro
226 demonstrate that the polarization of the EMV protein-sorting pathway can occur in morphologically non
229 d levels of EMV cargoes (i) polarize the EMV protein-sorting pathway, (ii) generate a nascent posteri
233 e most, if not all, previously characterized protein sorting pathways, the information that identifie
235 is a homologue of the yeast class C vacuolar protein sorting protein Vps33p that is involved in the b
236 the cytosolic tail (C-tail) of the vacuolar protein sorting receptor, Vps10p, is also efficiently tr
237 date the great diversity in secretory cargo, protein sorting receptors are required in a number of in
238 incorporation into COPII transport vesicles, protein sorting receptors release bound cargo in pre-Gol
242 il, containing the G-protein recognition and protein sorting sequences, exhibited a high mobility, in
246 Rabs and coiled transport factors to enable protein sorting specificity, could be applicable to vesi
247 m a coat-like complex, with AP-5 involved in protein sorting, SPG15 facilitating the docking of the c
248 the most distal stop and hence the ultimate protein-sorting station for distinct apical and basolate
250 d the class C Vps/HOPS (HOmotypic fusion and Protein Sorting) tether follow this model as their inter
251 it of the HOPS (homotypic fusion and vacuole protein sorting) tethering complex, all of which are req
252 ring) and HOPS (homotypic fusion and vacuole protein sorting) tethering complexes require their organ
253 plex) and HOPS (homotypic fusion and vacuole protein sorting)-tethering complex to elicit neuroprotec
254 tethering complex HOPS (homotypic fusion and protein sorting); the small GTPases Rab2, Rab7, and its
255 urvive under cell wall stress and for proper protein sorting through the carboxypeptidase Y pathway.
259 that (1) AP-3, BLOC-1, and BLOC-3 facilitate protein sorting to lysosomes to support ultimate secreti
261 together, these data indicate that membrane protein sorting to the INM is an active process involvin
264 I) 3-kinase in Saccharomyces cerevisiae, for protein sorting to the vacuole in yeast has exemplified
265 that enolase deficiency also prevents normal protein sorting to the vacuole, exacerbating the fusion
267 s-Golgi network (TGN), but the mechanism for protein sorting to this regulated secretory pathway (RSP
269 provides a platform for receptor signaling, protein sorting, transport, and endocytosis, whose regul
270 erved protein complex composed of a vacuolar protein sorting trimer (Vps 26/29/35) that participates
271 -enriched endosomal membranes and a vacuolar protein sorting (Vps) 26/29/35 trimer that participates
272 show that ESCRT-I and other class E vacuolar protein sorting (VPS) factors are linked by a complex se
273 P-1/ALIX, both of which are class E vacuolar protein sorting (VPS) factors, normally required for the
274 We validated the role of a set of vacuolar protein sorting (VPS) genes during infection, VPS51 to V
276 ires the recruitment of the class E vacuolar protein sorting (VPS) machinery by short, virally encode
277 require components of the cellular vacuolar protein sorting (VPS) machinery for efficient viral rele
278 Tsg101, a component of the class E vacuolar protein sorting (VPS) machinery, is required for the bud
279 ished a compilation of the 41 yeast vacuolar protein sorting (vps) mutant groups and described a larg
280 t in controlling dissociation using vacuolar protein sorting (vps) mutants that accumulate proteins i
281 ed protein complexes in the class E vacuolar protein sorting (VPS) pathway required for the sorting o
282 transport-1) complex protein in the vacuolar protein sorting (vps) pathway, to the plasma membrane du
283 tions in both HIV-1 budding and the vacuolar protein sorting (VPS) pathway, where it binds ubiquityla
285 een shown that ESCRT-I contains the vacuolar protein sorting (Vps) proteins Vps23, Vps28, and Vps37.
286 is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate ves
289 mammalian cells, the class III PI3K vacuolar protein sorting (Vps)34 is thought to play a critical ro
292 veloped viruses exploit the class E vacuolar protein-sorting (VPS) pathway to bud from cells, and use
293 ) and SNX2, homologues of the yeast vacuolar protein-sorting (Vps)5p, contain a phospholipid-binding
294 ursor protein (APP) mediated by the vacuolar protein sorting (Vps10) family of receptors plays a deci
295 bset of the mutations implicated in vacuolar protein sorting, vps34Delta, vps15Delta, vps45Delta, and
297 uncated peripherin/rds (Xper38)-GFP chimeric protein sorting was followed by immunofluorescence micro
298 Stn2) in mice compromises the fidelity of SV protein sorting, whereas the apparent speed of SV retrie
299 r, the endosome represents a dynamic site of protein sorting with a majority of proteins destined for
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