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1 r complex HOPS (homotypic fusion and vacuole protein sorting).
2 omain formation as a mechanism for endosomal protein sorting.
3 r these proteins in membrane trafficking and protein sorting.
4 is a model for the study of metal-regulated protein sorting.
5 early endosome processing and ubiquitinated protein sorting.
6 uitous clathrin adaptor AP-1A in basolateral protein sorting.
7 ansfer and lipid A synthesis and possibly by protein sorting.
8 propriate UNC-104 activity randomized axonal protein sorting.
9 d level of specificity in ubiquitin-mediated protein sorting.
10 ent with its previously reported function in protein sorting.
11 known function of the class C Vps complex in protein sorting.
12 rminus is vital for both voltage sensing and protein sorting.
13 th a particular focus on pathways regulating protein sorting.
14 a function of the BLOC-1 complex in membrane protein sorting.
15 disease-related defects in the regulation of protein sorting.
16 four ESCRT complexes in multivesicular body protein sorting.
17 domain proteins may be effectors of PI3P for protein sorting.
18 ous cellular functions such as signaling and protein sorting.
19 hip between raft association and subcellular protein sorting.
21 11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) domain-containing proteins.
25 that all six HOPS subunits (Vps11 [vacuolar protein sorting 11]/CG32350, Vps18/Dor, Vps16A, Vps33A/C
26 amino acid substitutions in Vps13 (vacuolar protein sorting 13), a large universally conserved eukar
27 warblers to identify a single gene-vacuolar protein sorting 13A (VPS13A)-that is associated with dis
30 viously described ESCRT-I subunits (vacuolar protein sorting 23, -28, and -37), suggesting a distinct
31 20/VPS25 (ELL-associated protein 20/vacuolar protein sorting 25) and the Bro1 proteins HD-PTP (His do
33 the protein-trafficking regulators vacuolar protein sorting 33A protein (VPS33A) or cappuccino prote
36 class III phosphoinositide 3-kinase vacuolar protein sorting 34 (Vps34) plays a central role in modul
38 wn of the autophagy-specific genes, vacuolar protein sorting 34 (VPS34), and autophagy-related protei
39 sphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes results in aber
40 beclin 1 is a core component of the vacuolar protein sorting 34 (Vps34)/class III phosphatidylinosito
42 ion of PI3KC3-C1 consisting of VPS (vacuolar protein sorting) 34, VPS15, BECN1 (Beclin 1), and ATG (a
43 bulation and membrane association of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), a
45 of one of its major components, the vacuolar protein sorting 35 (VPS35), has been reported in Alzheim
47 P-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting 35 homolog), and M6PR (mannose 6-phospha
49 he retromer core component FgVps35 (Vacuolar Protein Sorting 35) in the cytoplasm as fast-moving punc
50 uncharacterized factors, including vacuolar protein sorting 37 homolog A (VPS37A), transmembrane pro
52 inclusion in microvesicles, whereas vacuolar protein sorting 4 (VPS4) mediates scission of microvesic
53 is was blocked by dominant-negative vacuolar protein sorting 4 (Vps4), indicating that the Wnt pathwa
54 lopment, we identified an allele of Vacuolar protein sorting 4 (Vps4), which encodes an AAA ATPase th
56 ase activity of SKD1 (also known as Vacuolar Protein Sorting 4 or VPS4), a critical component require
58 als, the AAA ATPase Vps4p/SKD1 (for Vacuolar protein sorting 4/SUPPRESSOR OF K(+) TRANSPORT GROWTH DE
59 EGFR signaling by repressing Vps4b (vacuolar protein-sorting 4 homolog B), encoding a protein implica
61 nsport is likely to be regulated by vacuolar protein sorting 74 (Vps74p), a peripheral Golgi protein
63 also requires a histone chaperone, vacuolar protein sorting 75 (Vps75), as well as the major chapero
64 g protein C, fast type [MYBPC2] and vacuolar protein sorting 8 [VPS8], 2 families, 4.2%) or in anothe
65 dition of HOPS (homotypic fusion and vacuole protein sorting), a Ypt7p (Rab)-effector complex with a
66 e findings demonstrate that Erv26p acts as a protein sorting adaptor for a variety of Type II transme
71 specific mechanisms in terms of biogenesis, protein sorting and fate, which are far from completely
72 CA512 RESP18HD being a condensing factor for protein sorting and granulogenesis early in the secretor
74 d biological membranes, although its role in protein sorting and membrane function still remains uncl
76 titative live cell imaging method to analyze protein sorting and post-Golgi vesicular trafficking.
79 ctyostelium, we demonstrate that WASH drives protein sorting and recycling from macropinosomes and is
80 d the shp1Delta mutation, implicated in both protein sorting and regulation of the Glc7p protein phos
81 ons block VPS4 recruitment, impair endosomal protein sorting and relieve dominant-negative VPS4 inhib
82 neration of functionally distinct membranes, protein sorting and the development of polarized differe
84 l cells are known, but when and how directed protein sorting and trafficking occur to initiate cell s
85 idence that aberrant regulation of endosomal protein sorting and trafficking secondary to a dysfuncti
86 Recent evidence has implicated defective protein sorting and trafficking secondary to deficiencie
87 63-linked chains control ribosome function, protein sorting and trafficking, and endocytosis of memb
91 RT-II complex performs a central role in MVB protein sorting and vesicle formation, as it is recruite
94 e Vps-C complexes HOPS (homotypic fusion and protein sorting) and CORVET (class C core vacuole/endoso
96 ex termed HOPS (homotypic fusion and vacuole protein sorting), and soluble N-ethylmaleimide-sensitive
97 ESCRT-I/MVB12 subunits, Crag, a regulator of protein sorting, and bacterial pore-forming proteins mig
101 ctions in enveloped virus budding, endosomal protein sorting, and many other cellular processes.
105 nally, we show that CHX17 and CHX20 affected protein sorting as measured by carboxypeptidase Y secret
106 equences of Arn1p were required for vacuolar protein sorting, as mutation of ubiquitinatable lysine r
108 other retromer components SNX-3 and vacuolar protein sorting-associated protein 35 (VPS-35) did not a
109 usceptibility protein domains and a vacuolar protein sorting-associated protein 9 with a coupling of
110 ons for signaling at cell-cell junctions and protein sorting at intracellular contact points between
114 tween Drs2p and the AP-1 clathrin adaptor in protein sorting at the TGN and early endosomes of Saccha
116 in response to nutrient availability governs protein sorting at the TGN, likely by regulating sterol
117 These results establish a role for active protein sorting at the trans-Golgi en route to the plasm
123 f plasma membrane proteins and receptors and protein sorting between the trans-Golgi network (TGN) an
124 tor proteins implicated in clathrin-mediated protein sorting between the trans-Golgi network and endo
125 in mouse erythroblasts, nor at the membrane protein-sorting boundary in human erythroblasts, which d
128 rough interactions with the class C vacuolar protein sorting (C-Vps) tethering complex and endosomal
129 mbrane fusion is essential for intracellular protein sorting, cell growth, hormone secretion, and neu
131 tosis/actin dynamics (SLA1, SLA2, and END3), protein sorting (class E vps), and vesicle-vacuole fusio
133 partner for the homotypic fusion and vacuole protein sorting complex (a master regulator of vacuole f
134 is enhanced by homotypic fusion and vacuole protein sorting complex (HOPS) and Sec17p/Sec18p, the va
135 8) and its effector homotypic fusion/vacuole protein sorting complex (HOPS) to (phago)lysosome membra
136 hering complex, homotypic fusion and vacuole protein sorting complex (HOPS), and phosphoinositides, w
137 ddition of pure homotypic fusion and vacuole protein sorting complex (HOPS), which bears the vacuolar
141 -1, BLOC-2, and homotypic fusion and vacuole protein sorting complex subunits; clathrin; and phosphat
142 g complex HOPS (homotypic fusion and vacuole protein sorting complex), whereas the C-terminal SNARE m
144 vacuolar HOPS (homotypic fusion and vacuole protein sorting) complex in the yeast Saccharomyces cere
145 r4-Not complex, V-type ATPases, and vacuolar protein-sorting complexes as well as genes with unknown
147 e remodeling events that accompany endosomal protein sorting, cytokinesis, and enveloped RNA virus bu
148 rom the early endosomes (EE) requires active protein sorting decoded by a number of protein coats.
149 ular multiplication, CteG induced a vacuolar protein sorting defect when expressed in Saccharomyces c
150 The mammalian homologue of yeast vacuolar protein sorting defective 34 (mVps34) has been implicate
153 1 and Vps4p and exhibits synthetic vacuolar protein sorting defects when combined with mutations in
154 uired for transport (ESCRT), which regulates protein sorting during endosomal trafficking, this assoc
155 y was undertaken to explore whether aberrant protein sorting, during enucleation, creates these membr
158 Endosomes function as a hub for multiple protein-sorting events, including retrograde transport t
159 propose that the principle of membrane-based protein sorting extends to monotopic membrane proteins,
160 r a synthetic yeast prion, we identified two protein-sorting factors of the Hook family, termed Btn2
162 thers have observed in class C VPS (vacuolar protein sorting) family mutants and morphants, and we re
163 nent of the cellular machinery that controls protein sorting from endosomes to lysosomes and speciali
165 hree complexes, termed BLOC-1 to -3, mediate protein sorting from the early endosome to lysosomes and
166 he thylakoid-transfer signal is required for protein sorting from the stroma to thylakoids, mainly vi
168 asolateral plasma membrane domains depend on protein sorting from the trans-Golgi network (TGN) and v
172 mutants disrupted established VPS (vacuolar protein sorting) genes, The sixth, LTE1, is a Low Temper
176 a member of the homotypic fusion and vacuole protein sorting (HOPS) complex that delivers biosyntheti
177 the GTPase Rab7 and the homotypic fusion and protein sorting (HOPS) complex, but adaptor proteins tha
178 ntrolled by the homotypic fusion and vacuole protein sorting (HOPS) complex, rescued the neurotransmi
179 somal tethering homotypic fusion and vacuole protein sorting (HOPS) complex, was recently identified
180 bunit tethering homotypic fusion and vacuole protein sorting (HOPS) complex, which is essential for t
181 subunit of the homotypic fusion and vacuole protein sorting (HOPS) complex, which plays a key role i
184 hering (CORVET) and the homotypic fusion and protein sorting (HOPS) complexes, which have essential f
186 he multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is req
187 ther, the Vps-C/homotypic fusion and vacuole protein sorting (HOPS) subunit Vps41, and a SNARE, Vam3.
188 uolar/lysosomal homotypic fusion and vacuole protein sorting (HOPS) tethering complex combines both a
190 ane fusion, and homotypic fusion and vacuole protein sorting (HOPS), that serve as adaptors which tet
191 of their known roles in homotypic fusion and protein sorting (HOPS)-mediated vesicle tethering, are r
192 lipids, and the homotypic fusion and vacuole protein sorting (HOPS)/class C Vps complex, an effector
193 it of the yeast homotypic fusion and vacuole protein-sorting (HOPS) complex, bound to two individual
194 coding a subunit of the homotypic fusion and protein-sorting (HOPS) complex-as a critical determinant
196 members of the homotypic fusion and vacuole protein-sorting (HOPS) multisubunit tethering complex, w
197 c fusion and protein-sorting/class C vacuole protein-sorting (HOPS/class C Vps) complex can tether lo
200 that COP9-associated CSN5 regulates exosomal protein sorting in both a deubiquitinating activity-depe
203 e current model of polarized plasma membrane protein sorting in epithelial cells has been largely gen
204 nd mechanisms that regulate polarized apical protein sorting in hepatocytes, the major epithelial cel
205 trameric adaptor protein 1 (AP-1) complex in protein sorting in intracellular compartments is not yet
207 ptor protein (AP) complex family involved in protein sorting in the endomembrane system of eukaryotic
209 dressing fundamental questions, ranging from protein sorting in the photoreceptor cilium to photorece
211 M complex HOPS (homotypic fusion and vacuole protein sorting) increases the fusion of membranes beari
212 The Legionella pneumophila effector vacuolar protein sorting inhibitor protein D (VipD) localizes to
214 embranes requires host functions involved in protein sorting into late endosomal multivesicular bodie
216 wo-step kinetic and affinity-based model for protein sorting into the sequence-dependent recycling pa
217 role of the yeast Nedd4 homologue, Rsp5, in protein sorting into vesicles that bud into the multives
219 Stn2 and favor a model according to which SV protein sorting is guarded by both cargo-specific mechan
222 protein to a specific destination (known as protein sorting) is a crucial event that is intrinsicall
223 nsporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not
224 plast proteins engage one of four additional protein sorting mechanisms that direct targeting to the
225 ed in these studies regulates cargo-specific protein sorting mediated by the epithelial cell specific
227 hat there are probably multiple pathways for protein sorting/MVB vesicle formation in human cells and
228 inds two isoforms of the retromer-associated protein sorting nexin 3 (SNX3), including a novel isofor
229 ring RNA screens, we find that the endosomal protein sorting nexin 5 (SNX5)(3,4) is essential for vir
230 ave identified a novel intracellular adaptor protein, sorting nexin 17 (SNX17), that binds specifical
231 ave identified a unique rodent intracellular protein, sorting nexin 27 (SNX27), which regulates the t
232 The Phox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have e
233 the ESCRT proteins of the cellular vacuolar protein sorting pathway for efficient egress from the ce
236 y virus type 1 (HIV-1) exploits the vacuolar protein-sorting pathway by engaging Tsg101 and ALIX thro
237 demonstrate that the polarization of the EMV protein-sorting pathway can occur in morphologically non
240 d levels of EMV cargoes (i) polarize the EMV protein-sorting pathway, (ii) generate a nascent posteri
245 is a homologue of the yeast class C vacuolar protein sorting protein Vps33p that is involved in the b
246 date the great diversity in secretory cargo, protein sorting receptors are required in a number of in
247 incorporation into COPII transport vesicles, protein sorting receptors release bound cargo in pre-Gol
251 il, containing the G-protein recognition and protein sorting sequences, exhibited a high mobility, in
255 Rabs and coiled transport factors to enable protein sorting specificity, could be applicable to vesi
256 m a coat-like complex, with AP-5 involved in protein sorting, SPG15 facilitating the docking of the c
257 the most distal stop and hence the ultimate protein-sorting station for distinct apical and basolate
259 d the class C Vps/HOPS (HOmotypic fusion and Protein Sorting) tether follow this model as their inter
260 AREs, the HOPS (homotypic fusion and vacuole protein sorting) tethering and SNARE-assembly complex, a
261 it of the HOPS (homotypic fusion and vacuole protein sorting) tethering complex, all of which are req
262 ring) and HOPS (homotypic fusion and vacuole protein sorting) tethering complexes require their organ
263 plex) and HOPS (homotypic fusion and vacuole protein sorting)-tethering complex to elicit neuroprotec
264 tethering complex HOPS (homotypic fusion and protein sorting); the small GTPases Rab2, Rab7, and its
265 urvive under cell wall stress and for proper protein sorting through the carboxypeptidase Y pathway.
269 that (1) AP-3, BLOC-1, and BLOC-3 facilitate protein sorting to lysosomes to support ultimate secreti
273 that enolase deficiency also prevents normal protein sorting to the vacuole, exacerbating the fusion
274 s-Golgi network (TGN), but the mechanism for protein sorting to this regulated secretory pathway (RSP
276 provides a platform for receptor signaling, protein sorting, transport, and endocytosis, whose regul
277 erved protein complex composed of a vacuolar protein sorting trimer (Vps 26/29/35) that participates
278 -enriched endosomal membranes and a vacuolar protein sorting (Vps) 26/29/35 trimer that participates
279 We validated the role of a set of vacuolar protein sorting (VPS) genes during infection, VPS51 to V
280 ires the recruitment of the class E vacuolar protein sorting (VPS) machinery by short, virally encode
281 ished a compilation of the 41 yeast vacuolar protein sorting (vps) mutant groups and described a larg
282 t in controlling dissociation using vacuolar protein sorting (vps) mutants that accumulate proteins i
283 ed protein complexes in the class E vacuolar protein sorting (VPS) pathway required for the sorting o
284 transport-1) complex protein in the vacuolar protein sorting (vps) pathway, to the plasma membrane du
286 een shown that ESCRT-I contains the vacuolar protein sorting (Vps) proteins Vps23, Vps28, and Vps37.
287 is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate ves
290 mammalian cells, the class III PI3K vacuolar protein sorting (Vps)34 is thought to play a critical ro
294 ursor protein (APP) mediated by the vacuolar protein sorting (Vps10) family of receptors plays a deci
295 bset of the mutations implicated in vacuolar protein sorting, vps34Delta, vps15Delta, vps45Delta, and
297 uncated peripherin/rds (Xper38)-GFP chimeric protein sorting was followed by immunofluorescence micro
298 Stn2) in mice compromises the fidelity of SV protein sorting, whereas the apparent speed of SV retrie
299 r, the endosome represents a dynamic site of protein sorting with a majority of proteins destined for