ライフサイエンスコーパス: protein stability

1 ylatable form, differentially affected their protein stability.

2 ods that were fitted specifically to predict protein stability.

3 w that COL12 overexpression did not alter CO protein stability.

4 BP-1a caused an increase of nuclear SREBP-1a protein stability.

5 e importance of the hydrogen bond network in protein stability.

6 ed to engage WBP2 primarily by affecting its protein stability.

7 haracterize the effect of STAT3 mutations on protein stability.

8 oteins - the intrinsically low thermodynamic protein stability.

9 ophila gene, stuxnet (stx), that controls Pc protein stability.

10 Depletion of KDM4A decreases DEPTOR protein stability.

11 cluster and dioxygen in cluster transfer and protein stability.

12 32 has an important role in regulating SRp20 protein stability.

13 EN ubiquitination sites in the regulation of protein stability.

14 g transcription and increasing IRF1 mRNA and protein stability.

15 these revealed primarily an influence on the protein stability.

16 d as a major system for regulated control of protein stability.

17 e of a proteostasis network that can "sense" protein stability.

18 action with the C terminus and also affected protein stability.

19 as the R381Q and V362I variants have reduced protein stability.

20 n globally quantifying the impact of SNVs on protein stability.

21 uated the effect of an implicated variant on protein stability.

22 ription, mRNA processing, mRNA stability, or protein stability.

23 me observed in vivo results from altered POR protein stability.

24 hat depended on combinations of affinity and protein stability.

25 uring the lifecycle operates at the level of protein stability.

26 ldrich interacting protein and decreases its protein stability.

27 r Mcl-1 mRNA levels but rather decreased its protein stability.

28 equences has comparable outcomes on a target protein stability.

29 indicating the important role of entropy in protein stability.

30 F-1alpha), likely through enhancement of its protein stability.

31 Oylation, which affect PTEN localization and protein stability.

32 ns to be affected primarily by disruption of protein stability.

33 n dynamics, likely leading to an increase in protein stability.

34 tein in neurons by chemically regulating its protein stability.

35 notypic errors via amino acids that increase protein stability.

36 rylation reduces plasticity due to increased protein stability.

37 gnals and actin depolymerization promote Ski protein stability.

38 smembrane domains of RNF170 are required for protein stability.

39 ential for maintaining ASXL2, but not ASXL1, protein stability.

40 directly interact with Ras, which increases protein stability.

41 t deubiquitinate UbK48 chains or affect E2F1 protein stability.

42 effect is not mediated through altered PTEN protein stability.

43 om proteasomal degradation and increased its protein stability.

44 demonstrate that PTPN14 increases the LAST1 protein stability.

45 AGT specific activity, and one that assesses protein stability.

46 f LIN28A increases its nuclear retention and protein stability.

47 d for predicting the effects of mutations on protein stability.

48 ence metabolic traits through altered TM6SF2 protein stability.

49 f the cytoplasm, which is expected to affect protein stability.

50 ng polyubiquitination of PTEN and decreasing protein stability.

51 , matching theoretical predictions of global protein stability.

52 the CaV2.1 protein level and enhances CaV2.1 protein stability.

53 tro, but leads to rickets by decreasing VEGF protein stability.

54 ndicated that PD184161 influenced HIF-1alpha protein stability.

55 ormal primary keratinocytes due to increased protein stability.

56 fic sites in ESR1 RNA and by increasing ESR1 protein stability.

57 network predominantly through increasing MYC protein stability.

58 atic pressure can both increase and decrease protein stability.

59 Disulfide bonds contribute to protein stability, activity, and folding in a variety of

60 utcomes such as protein-protein association, protein stability, activity, and improve imaging capabil

61 and drug discovery, the factors that govern protein stabilities and structures in a solvent-free env

62 tations causing a threshold-like decrease in protein stability and a concomitant loss of fluorescence

63 nt route to modify its properties, improving protein stability and activity as a formulation excipien

64 which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism

65 hese motions in order to accurately optimize protein stability and binding affinity.

66 ation-defective mutant (S69G) that increased protein stability and blocked BIM induction.

67 ereas currently available tools can increase protein stability and combining them into a meta-predict

68 , the effects of hydrodynamic flow fields on protein stability and conformation remain poorly underst

69 ellular Notch (NICD), resulting in increased protein stability and constitutive Notch1 signaling.

70 ization showed that four mutations increased protein stability and could be amplified through ThreeFo

71 document that gankyrin regulates HIF-1alpha protein stability and cyclin D1 expression, ultimately m

72 s indicate that Nasu-Hakola mutations impact protein stability and decrease folded TREM2 surface expr

73 e R161Q and R161G CblC mutants display lower protein stability and decreased dealkylation but not dec

74 ed pathogenic roles for (a) perturbations in protein stability and degradation, (b) altered homeostas

75 ereas loss of HDAC5 by siRNA diminished LSD1 protein stability and demethylation activity.

76 oportional to their thermodynamic impacts on protein stability and DNA binding, which is consistent w

77 ective method for localizing and determining protein stability and dynamics.

78 Several EA2-causing mutants exhibit impaired protein stability and exert dominant-negative suppressio

79 t proteins in yeast, demonstrating a loss of protein stability and failure to restore growth to profi

80 rotein synthesis was accompanied by enhanced protein stability and folding and not by markers of prot

81 harge-charge interactions are fundamental to protein stability and folding kinetics in cells.

82 (57) and Cys(146), which have been linked to protein stability and folding via forming a disulfide bo

83 Regulation of protein stability and function in vivo begins during pro

84 bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer

85 all organisms, play a crucial role in tuning protein stability and function under variable external c

86 ted single amino acid replacements affecting protein stability and function.

87 or (CFTR), leading to detrimental changes to protein stability and function.

88 They are also costly, because they reduce protein stability and help create toxic misfolded protei

89 Hypercapnia suppressed HIF-alpha protein stability and HIF target gene expression both in

90 d immunoblot analysis were used to determine protein stability and immunoreactivity, respectively.

91 vestigate the effect of somatic mutations on protein stability and in vitro fibril formation of singl

92 ith holdase chaperone activity, enhances PSY protein stability and increases the enzymatically active

93 their impact on signaling, gene expression, protein stability and interactions, and enzyme kinetics.

94 tiple functions on CLC-proteins: it modifies protein stability and intracellular trafficking as well

95 cylation, and O-GlcNAcylation promoted Bmi-1 protein stability and its oncogenic activity.

96 n addition, TGFbeta signaling increases GRM3 protein stability and knockdown of GRM3 enhances TGFbeta

97 t drug screening of P450s is limited by poor protein stability and lack of consistent measurement of

98 rmore, the N-glycans are shown to extend the protein stability and lifetime by protection against pro

99 The protein stability and loading capacity was further impro

100 mutating residue 173 from Asn to Thr alters protein stability and misfolding only subtly, whilst cha

101 we show these ERF mutations cause decreased protein stability and mostly occur in tumours without ER

102 dy suggests that these variants affect MRPP1 protein stability and mt-tRNA processing without affecti

103 osting membrane expression of TRPC6, whereas protein stability and multimerization of TRPC6 are not a

104 ver, promoting mono-ubiquitination increases protein stability and nuclear localization of mutant PTE

105 Analysis of protein stability and oligomeric state demonstrates that

106 ts of the beta2-alpha2 loop sequence on both protein stability and on specific misfolding pathways.

107 n of MAF protein, resulting in increased MAF protein stability and PI resistance.

108 ulation technology that effectively enhances protein stability and PK while mitigating the immune res

109 tical role in this process by regulating its protein stability and plasma membrane targeting.IMPORTAN

110 distal to the active site and essential for protein stability and possible heterodimerization with o

111 king the destruction box and hence increased protein stability and prolonged inhibition of replicatio

112 Moreover, we observed changes in protein stability and protein-protein interactions in th

113 ing approaches for identifying regulators of protein stability and reveal Siah2 as a previously unide

114 well with predicted effects of mutations on protein stability and RNA binding affinity.

115 indicate that they have a role in regulating protein stability and signaling transduction pathways.

116 due loop region that appear to play roles in protein stability and SMC3 substrate binding.

117 and GPCR signals differentially regulate Ski protein stability and sorting in hepatocytes, and this c

118 hat the Polo-like kinase Cdc5 regulates Ndj1 protein stability and SPB separation.

119 es of glycosylation can distinctly influence protein stability and structure.

120 Protein ubiquitination controls protein stability and subcellular localization of tyrosi

121 on MgCh in vitro and in vivo but retains its protein stability and tetrapyrrole binding capacity.

122 esized that AD-HIES mutations decrease STAT3 protein stability and that mutant STAT3 activity can be

123 erturb the folding equilibrium for examining protein stability and the protein folding process.

124 PTP1B dephosphorylates PITX1 to weaken its protein stability and the transcriptional activity for p

125 ess usually involves an initial reduction in protein stability and then the subsequent oligomerizatio

126 ccordingly, we show that CHIP regulates PKM2 protein stability and thereafter the energy metabolic pr

127 reas its overexpression influences both hp53 protein stability and transcription of targeted genes.

128 Although Akt is known to regulate protein stability and transcription, we found that gB- a

129 ation of HIF-1alpha and increases HIF-1alpha protein stability and transcriptional activity.

130 on of Tyr429*, pathogenic mutations decrease protein stability and trigger protein misfolding.

131 eveal that the S5-pore helix loop influences protein stability and vanilloid and proton responses, bu

132 in vitro assays of specific DNA binding and protein stability, and (ii) cell culture-based assays of

133 ations that regulate its enzymatic activity, protein stability, and cellular location.

134 onships between mutation, protein structure, protein stability, and epistasis and quantitatively depi

135 n conformational changes, yet their role for protein stability, and for unfolding, remains elusive.

136 energy homeostasis by controlling PGC-1alpha protein stability, and further implicate altered mitocho

137 s of SUMO in IFN signaling, gene expression, protein stability, and IFN-induced biological responses.

138 d its cytosolic domain link the mutations to protein stability, and the ability to induce an active d

139 Using a global protein stability approach, we determined the half-life

140 While both kinetic and thermodynamic protein stability are analysed by varying scan rates and

141 Tcf1 isoforms indicate that Tcf1 dosage and protein stability are critical in suppressing IFN-gamma

142 and regulatory mechanisms that control SOX9 protein stability are poorly understood.

143 intact endosomal compartment, and controlled protein stability are the likely prerequisites for AQP1

144 he effects of protein-ligand interactions on protein stability are typically monitored by a number of

145 , the addition of FAD significantly improved protein stability, arguing for a chaperone-like action s

146 17A acts to increase TNF-alpha-induced COX-2 protein stability as confirmed by cycloheximide chase ex

147 Both DCHS1 mutations reduce protein stability as demonstrated in zebrafish, cultured

148 ll-molecule chemical features and changes in protein stability as evidence to train a predictive mode

149 elch superfamily of proteins, which modulate protein stability as substrate-specific adaptors for ubi

150 information beyond that needed for defining protein stability at single amide resolution.

151 ying these tools are needed to avoid gaining protein stability at the cost of solubility.

152 e unprecedented ability to accurately assess protein stability at the resolution of a single amino ac

153 ical factors at determining the DFE, such as protein stability, back-mutations, species complexity, a

154 does not affect CSB's catalytic activity or protein stability, but greatly affects genome stability,

155 c cells was not due to a difference in CXCL1 protein stability, but instead to a decrease in Cxcl1 mR

156 epends on its phosphorylation status and its protein stability, but the regulation of BES1 is not wel

157 remain challenging, not only because of poor protein stability, but they also experience fast clearan

158 oposed to predict the effect of mutations on protein stability; but most require features from experi

159 vel molecular mechanism for regulating PD-L1 protein stability by a cell cycle kinase and reveals the

160 Rather, BOK is controlled at the level of protein stability by components of the endoplasmic retic

161 ber BOK, which is controlled at the level of protein stability by ER-associated degradation component

162 omotes C/EBPdelta expression at the level of protein stability by inhibition of the FBXW7 pathway.

163 The mutations disrupted protein stability by interfering with homodimerization o

164 was tolerated, the G4934V mutation decreased protein stability by introducing clashes with neighborin

165 Here, we report the regulation of SETD2 protein stability by the proteasome system, and the iden

166 Thus, the regulation of protein stability by Urm1 and the proteasome in archaea

167 Mechanistically, miR-542-3p increased p53 protein stability by weakening interactions between p53

168 to proteins and not specifically fitted for protein stability calculations, performs well compared t

169 e, we describe the FEP+ method as applied to protein stability calculations, summarize the large-scal

170 sponse correlation with gene expression, and protein stability changes for all mutLBSgenes using inte

171 irely new representation of mutation induced protein stability changes that could not be obtained fro

172 For the prediction of membrane protein stability changes upon mutation, the proposed to

173 sting methods in the predictions of globular protein stability changes upon mutation.

174 ons of protein-ligand binding affinities and protein stability changes upon mutation.

175 Besides the classic role in maintaining protein stability, chaperones have additional roles in t

176 rent steps of transcription, translation and protein stability control by a variety of cell-intrinsic

177 interactions and other local determinants of protein stability, cooperativity, and potentially also o

178 pressive effects of hypercapnia on HIF-alpha protein stability could be mimicked by reducing intracel

179 idence that N-termini could act as important protein stability determinants in plastids.

180 yrate (PBA), a chemical chaperone, increased protein stability, enzymatic activity, membrane-associat

181 try assays and confocal imaging; 2) decrease protein stability estimated from cycloheximide chase ass

182 tion from an HDX dataset to generate a HDXMS protein stability fingerprint.

183 proach to predict the effect of mutations on protein stability from non-equilibrium unfolding simulat

184 lculations can be used to predict changes in protein stability from point mutations without parameter

185 iency in alkene production and in regulating protein stability, heme iron coordination, and spin stat

186 OR signaling significantly diminishes FBP1/2 protein stability in a caspase-3/-7-dependent manner.

187 HSF1 as a critical factor in modulating HSF1 protein stability in addition to its previously identifi

188 additional MIB2 variant (p.V984L) affecting protein stability in an unrelated isolated case with LVN

189 modifications and are major determinants of protein stability in bacteria, eukaryotes, and perhaps a

190 T58 is a critical function in regulating Myc protein stability in breast cancer.

191 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells.

192 fect of transient attractive interactions on protein stability in cells and provide a new explanation

193 2 that contributes to the regulation of Mdm2 protein stability in cells.

194 Here, we quantify protein stability in living Escherichia coli cells befor

195 We found that Rad9 is required for Neil1 protein stability in mouse ES cells, whereas it regulate

196 d decreased caspase-8 protein expression and protein stability in normal fibroblasts compared with ca

197 host interactions and pathogen-mediated host protein stability in order to promote intracellular surv

198 been developed for in silico predictions of protein stability in recent years, ranging from sequence

199 escribe biosensors that provide readouts for protein stability in the cytosolic compartment of prokar

200 Importantly, this compound alters Bax protein stability in vitro and promotes the insertion of

201 nates iron in a 2Fe-2S cluster that enhances protein stability in vitro.

202 otency gradient correlated directly with ATH protein stability, including in response to Notch signal

203 Z in the whole protein resulted in decreased protein stability, including pre-fusion conformation sta

204 turation temperatures, our results show that protein stability increases by 55 degrees C in the ionic

205 Studies analyzing protein stability indicate that HPV may also protect Rad

206 of the thermodynamic impact of mutations on protein stability indicated that although the G4934A mut

207 ns has emerged as a useful method to enhance protein stability, investigate protein-protein interacti

208 and the molecular mechanisms controlling Ski protein stability involve the participation of actin cyt

209 Here we show conclusively that protein stability is affected by volume exclusion and th

210 ll is a densely crowded environment in which protein stability is affected differently than in dilute

211 In addition, Cdc25C protein stability is also decreased following DNA damage

212 Increasing protein stability is an especially challenging task, wit

213 The rational and predictable enhancement of protein stability is an important goal in protein design

214 Protein stability is concurrently affected by the resist

215 Ski protein stability is decreased by TGF-beta/Smads, GPCR/R

216 r the first time, we are reporting that MUC4 protein stability is drastically affected in PC, under h

217 CaV2.1 protein stability is dynamically regulated by RNF138 and

218 A key regulatory system for protein stability is given by the ubiquitin proteasome p

219 Here, we show that G9a protein stability is increased in hypoxia via reduced pr

220 We show also that DeltaNp63alpha protein stability is negatively regulated by the interac

221 lymphopoiesis, and demonstrate how Cyclin D3 protein stability is negatively regulated during exit fr

222 Protein stability is positively regulated by anti-adapto

223 BCL6 protein stability is regulated by F-box protein 11 (FBXO

224 Mdm2 protein stability is regulated by several mechanisms inc

225 en together, our findings indicate that MLL4 protein stability is tightly regulated by its H3K4 methy

226 current acellular pertussis vaccines due to protein stability issues and a poor understanding of its

227 ever, little is known regarding how GSK3beta protein stability itself is regulated and how its stabil

228 is largely a result of Hofmeister effects on protein stability leading to protein unfolding in the he

229 Reduction in HIF-1alpha protein stability led to attenuation of the binding with

230 c activity but instead negatively influenced protein stability, likely due to a loss of supportive in

231 standing of how this modification influences protein stability, localization, and function.

232 that dimerization-driven regulation of bHLH protein stability may be a conserved mechanism for diffe

233 his chemical strategy for controlling target protein stability may have implications for therapeutica

234 atory systems, including miRNAs and multiple protein stability mechanisms, work at different levels t

235 We propose that protein stability, mediated by DNA repair protein comple

236 -wide human E3-substrate interaction network.Protein stability modulation by E3 ubiquitin ligases is

237 ing effect is not mediated by increased SNC1 protein stability, nor is it fully dependent on the accu

238 ng these polymorphisms primarily affect Msh3 protein stability, not activity.

239 D2 are partially independent regarding their protein stability, nuclear localization and chromatin re

240 Additionally, the protein stability of cell surface-expressed Kv1.2 channe

241 The protein stability of CLC-1 is notably increased by FKBP8

242 The protein stability of FOXO3A is regulated by Casein Kinas

243 -mediated acetylation of HIPK2 increases the protein stability of HIPK2 and enhances its tumor suppre

244 udy, we present evidence suggesting that the protein stability of HIPK2 can be regulated by p300-medi

245 The lower protein stability of isolated mitochondria and the lack

246 ethylation levels in ES cells, decreases the protein stability of MLL3 and MLL4 but not that of H3K4

247 The opposite regulation of protein stability of MYCs and JAZs by FR-enriched light

248 t Y160, Y175, and Y179 to further weaken the protein stability of PITX.

249 nalyses showed that general features such as protein stability of the Pmt4 variants were not signific

250 further demonstrated that HDAC5 promoted the protein stability of USP28, a bona fide deubiquitinase o

251 putational prediction of mutation impacts on protein stability offers a fast, economical and potentia

252 n structure and function, either by altering protein stability or interactions with its partners, she

253 se mutation in VPS35 does not compromise its protein stability or localization to endosomal and lysos

254 ined that KEAP1 does not regulate total MCM3 protein stability or subcellular localization.

255 mutated without a loss in binding affinity, protein stability, or enzymatic activity, suggesting pla

256 in 2 families) affected BRF1 mRNA splicing, protein stability, or expression and/or function.

257 atively little effect on protein expression, protein stability, or PTEN polyubiquitination.

258 th this regulatory change, which reduced RCO protein stability, preventing pleiotropic effects caused

259 t the molecular level, Ctr9 enhances ERalpha protein stability, promotes recruitment of ERalpha and R

260 at more crowded conditions can only increase protein stability, recent work shows that crowding can d

261 (PVP), which leads to significantly improved protein stability, reduced macrophage uptake, prolonged

262 ional properties, but lead to, e.g., reduced protein stability, reduced protein expression, or defect

263 isms involved in the maintenance of GSK3beta protein stability remain ambiguous.

264 ver, the molecular regulation of Smad2/Smad3 proteins stability remains a mystery.

265 gorous free energy-based approach applied to protein stability reported to date: 700+ single-point mu

266 sis through regulation of ABA 8'-hydroxylase protein stability, representing a novel control point in

267 between HBZ and APH-2 transcript levels and protein stability, respectively.

268 ein, and that p.Leu208Pro results in reduced protein stability, resulting in decreased HA inactivatio

269 Ogamma-H...Ndelta1 His H-bond and decreases protein stability, results in a 25% increase in (2h)J(NN

270 reover, PLK1 activity is important for FOXC2 protein stability, since PLK1 inhibition reduces FOXC2 p

271 ivity, which is attributed to differences in protein stability, subcellular distribution, and/or RNA

272 Engineering of these loop regions can alter protein stability, substrate binding and even dramatical

273 evolutionarily and associated with decreased protein stability, suggesting a likely impact on protein

274 on on EGFR-K521 that associated with reduced protein stability, suggesting a structural basis for red

275 Y/Q917H was more significantly impaired than protein stability, suggesting that surface trafficking o

276 thin the kinase domain, or are important for protein stability, suggesting they lead to a loss of the

277 468Q, N348Q/N812Q, and N468Q/N812Q decreased protein stability/synthesis and nearly abolished steady-

278 Asn-348, Asn-468, and Asn-812 contribute to protein stability/synthesis of CaValpha2delta1, and furt

279 nificantly greater BV incorporation rate and protein stability than the bacteriophytochrome (BPH) FPs

280 have defined a role for heme in conditional protein stability that has been subsequently described i

281 volves a genetic selection for intracellular protein stability that is based on the folding quality c

282 the ability of GSK-3beta to modulate IL-22R protein stability that might have significant implicatio

283 s follows: those that significantly decrease protein stability; those that destroy favorable intermol

284 novel regulatory mechanism that controls ACS protein stability through a heterodimerization of ACS is

285 es-whereas knockdown of ZFP871 increases-p53 protein stability through a proteasome-dependent degrada

286 chains contribute significantly to membrane protein stability through either aromatic-aromatic inter

287 ssesses the effects of these interactions on protein stability through measuring resistance to unfold

288 st that HDAC5 is critical in regulating LSD1 protein stability through post-translational modificatio

289 e found a novel mechanism that regulates Ski protein stability through TGF-beta and G protein-coupled

290 ibitors (HDACi) as agents reducing DeltaNp63 protein stability through the E3 ubiquitin ligase, Fbw7.

291 There is great interest in increasing proteins' stability to enhance their utility as biocatal

292 BRG2 variants were functionally assessed for protein stability, trafficking, postsynaptic clustering,

293 Accurately predicting changes in protein stability upon amino acid substitution is a much

294 the effect of Gly-to-d-Ala substitutions on protein stability using experimental approaches together

295 ally, we discovered that DDB1 enhances FOXO1 protein stability via degrading the circadian protein cr

296 attributed to gankyrin mediating HIF-1alpha protein stability via the ubiquitin-proteasome pathway.

297 By comparing protein stabilities, we show that SMXL3/4/5 proteins fun

298 cids from mammals or vertebrates can enhance protein stability when incorporated into human proteins.

299 of the roles of various phytohormones on ACS protein stability, which brings new insights into crosst

300 which SET9 controls DNA methyltransferase-1 protein stability, which represses the transcriptional a