ライフサイエンスコーパス: protein synthesis

1 sfer RNA modifications play pivotal roles in protein synthesis.

2 in abundance with no detectable increase in protein synthesis.

3 s ribosomal RNA transcription and attenuates protein synthesis.

4 to the cytoplasm, their site of function for protein synthesis.

5 o the cytoplasm, and resultant disruption of protein synthesis.

6 determinant of the rate and processivity of protein synthesis.

7 tely high-protein meals improves 24-h muscle protein synthesis.

8 s with a short half-life and minimal ongoing protein synthesis.

9 concurrently with eEF2K-dependent increased protein synthesis.

10 w that the guidance of axons by Shh requires protein synthesis.

11 eved to drive disease by slowing the rate of protein synthesis.

12 in the cytosol together possibly engaged in protein synthesis.

13 IF2alpha) resulting in inhibition of general protein synthesis.

14 n, indicating a role for S6K1 independent of protein synthesis.

15 naptic plasticity and memory require de novo protein synthesis.

16 machinery to direct the initiation of viral protein synthesis.

17 alpha-subunit of eIF2 downregulates cellular protein synthesis.

18 ve one cellular block that occurs after late protein synthesis.

19 f RNA and proteins and it is responsible for protein synthesis.

20 commissural axons up a Shh gradient requires protein synthesis.

21 that is marked by global inhibition of host protein synthesis.

22 inhibition of either ribosome biogenesis or protein synthesis.

23 azF-mt6 cleaves 23S rRNA Helix 70 to inhibit protein synthesis.

24 describe a novel mechanism that limits ZEB2 protein synthesis.

25 layed a dominant role in the shutoff of host protein synthesis.

26 mplex 1 (mTORC1), and subsequent increase in protein synthesis.

27 ation factor that exerts strong control over protein synthesis.

28 regulation of cellular mRNA is essential for protein synthesis.

29 translation are followed by normalization of protein synthesis.

30 ut pathogens react to bile by adapting their protein synthesis.

31 rated the role of USP36 in ribosomal RNA and protein synthesis.

32 g differentiation, despite decreased general protein synthesis.

33 ar-signal regulated kinase-dependent de novo protein synthesis.

34 am of viral replication but upstream of late protein synthesis.

35 acid to the growing polypeptide chain during protein synthesis.

36 osomes defines the location and capacity for protein synthesis.

37 the translocation of deacylated tRNA during protein synthesis.

38 ctor RF2, which catalyses the termination of protein synthesis.

39 s coordinated changes in gene expression and protein synthesis.

40 density, and increased shutoff of host cell protein synthesis.

41 earning, and memory by controlling dendritic protein synthesis.

42 a signaling pathway that regulates synaptic protein synthesis.

43 C1, a multisubunit host kinase that controls protein synthesis.

44 erase I regulatory factors and regulators of protein synthesis.

45 or L-LTP through regulating activity-induced protein synthesis.

46 n with a phase opposite to that of ribosomal protein synthesis.

47 e signalling that is required for fibrogenic protein synthesis.

48 ide sequence with amino acid sequence during protein synthesis.

49 ve processes, the most demanding of which is protein synthesis.

50 occur, in order to preserve the integrity of protein synthesis.

51 expression in cis, thereby inhibiting Ndc80 protein synthesis.

52 genes to the disparate, cytoplasmic sites of protein synthesis.

53 e imino acid proline is a poor substrate for protein synthesis.

54 f mefloquine derivatives to inhibit parasite protein synthesis.

55 in induces ribosomal pausing and compromises protein synthesis.

56 of E-site codons to modulate the dynamics of protein synthesis.

57 es IRE-mRNA/IRP1 binding, increasing encoded protein synthesis.

58 layer 5 pyramidal neurons and lower general protein synthesis.

59 IF2alpha dephosphorylation and resumption of protein synthesis.

60 esponse that couples energy availability and protein synthesis.

61 ization but also genes important for general protein synthesis.

62 ity, seizures, and elevated de novo synaptic protein synthesis.

63 ion of noncanonical functions of EPRS beyond protein synthesis.

64 can both be characterized by slower rates of protein synthesis.

65 MBONs through sequential ORB-regulated local protein synthesis.

66 dation of extinction memory requires de novo protein synthesis.

67 nimal model using only three constraints: 1) protein synthesis, 2) protein degradation, and 3) positi

68 We detected initiation of protein synthesis above measurement background for 47 co

69 sis rates and the ability to increase muscle protein synthesis after protein ingestion.

70 nutrient shifts owing to a rigid strategy of protein synthesis allocation, which is not directed towa

71 , this fusion is active in E. coli live-cell protein synthesis allowing peptidyl transfer at a rate s

72 rease in cytoplasmic TDP-43 represses global protein synthesis, an effect which is rescued by overexp

73 pends on two functionally distinct phases of protein synthesis: an early phase that appears to prime

74 Furthermore, cyclosporin A decreased protein synthesis and abolished proliferation in wild-ty

75 t resource for studies on the roles of local protein synthesis and axon degeneration in ALS and can s

76 sis that results in impaired skeletal muscle protein synthesis and breakdown (proteostasis).

77 ning (RET) has a beneficial effect on muscle protein synthesis and can be augmented by protein supple

78 ion, and its absence leads to suppression of protein synthesis and cell cycle arrest.

79 3K-mediated signalling, attenuates excessive protein synthesis and corrects dendritic spine abnormali

80 ately predicts underlying rate parameters of protein synthesis and degradation as well as experimenta

81 In many cell types, imbalance between protein synthesis and degradation can induce endoplasmic

82 investigated how rates of mRNA translation, protein synthesis and degradation contribute to the stea

83 the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking,

84 esis but also regulates the tight balance of protein synthesis and degradation.

85 d by contraction-induced, increased rates of protein synthesis and dietary protein availability.

86 ich exhibited a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV

87 s facilitating eukaryotic cells to attenuate protein synthesis and energy consumption to adapt to ene

88 to be involved solely in ribosome-dependent protein synthesis and essential primary metabolism proce

89 ISRIB additionally normalized the lower protein synthesis and higher E/I ratio in the PFC.

90 omal translation factors are fundamental for protein synthesis and highly conserved in all kingdoms o

91 t pathology and functional decline, dampened protein synthesis and increased tolerance of proteostati

92 acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA translation ar

93 he CaMKII inhibitor tatCN21 increased global protein synthesis and induced behavioral resistance to k

94 ctivated by interferons and dsRNAs, inhibits protein synthesis and induces apoptosis.

95 nd in particular the PERK branch, can reduce protein synthesis and initiate cell death through induct

96 s growth signals with metabolic pathways and protein synthesis and is hyperactivated in many human ca

97 ent upon actin but is independent of de novo protein synthesis and is modulated by stress conditions

98 ion activates AMPK (Threonine 172), blunting protein synthesis and mTOR signaling, culminating in a d

99 l site for the regulation of skeletal muscle protein synthesis and muscle mass, it does not appear to

100 ons exhibited enrichment of mRNAs related to protein synthesis and nerve regeneration.

101 Usp14 inhibition did not appreciably alter protein synthesis and only partially delayed protein deg

102 its of the mitoribosome acting to coordinate protein synthesis and OXPHOS assembly events and thus th

103 o low-energy-induced stress as infected cell protein synthesis and productive replication were reduce

104 me Entry Site (IRES) structure to facilitate protein synthesis and promote genome replication.

105 show that the process of E. coli induction, protein synthesis and protein export is highly stochasti

106 ity of TrpRS, which subsequently compromised protein synthesis and reduced cell viability.

107 IRS1 proteins antagonize PKR to promote HCMV protein synthesis and replication; however, the mechanis

108 nhardtii to quantify the effects of miRNA on protein synthesis and RNA abundance.

109 lation is a potential mechanism of ribosomal protein synthesis and stoichiometry.

110 ubstitutes for polyamines to promote general protein synthesis and that the hypusine modification on

111 oduction from 2-(methylthio)ethanol requires protein synthesis and that this process is regulated.

112 l amino acid for humans and is important for protein synthesis and the formation of polyamines and is

113 or components of the ribosomal machinery for protein synthesis and they also serve in non-ribosomal p

114 insufficiency that would otherwise restrict protein synthesis and virus replication.

115 res such as reduced proliferation, decreased protein synthesis, and activation of p53 and its target

116 NAPRT silencing reduced energy status, protein synthesis, and cell size in ovarian and pancreat

117 phosphorylation that requires SMADs, de novo protein synthesis, and contribution from JAK1.

118 Cell size, protein synthesis, and fat and glycogen storage are repr

119 observed reduced myotube diameter, impaired protein synthesis, and increased autophagy flux in respo

120 onine at position 56, resulting in increased protein synthesis, and made mice resistant both biochemi

121 Myotube diameter, protein synthesis, and molecular responses in C2C12 muri

122 ions cannot reach the timescales relevant to protein synthesis, and most conventional structure-based

123 d proliferation rates, alterations in global protein synthesis, and perturbations in redox homeostasi

124 uptake, CAT1 and CAT2 protein levels, total protein synthesis, and phosphorylation of mTOR, S6K, and

125 hanges in protein translation, mitochondrial protein synthesis, and posttranslational regulation of t

126 th HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand

127 cin A chain can cause toxicity by inhibiting protein synthesis, and ricin B can bind to the galactose

128 f mitochondrial stress signalling, increased protein synthesis, and suppression of signatures of cell

129 blasts, responsible for extracellular matrix protein synthesis, and the macrophages infiltrating the

130 antagonist), and NLRP3 transcripts, de novo protein synthesis, and the release of pro- and mature IL

131 es controlling cell survival, proliferation, protein synthesis, and vesicle trafficking.

132 oderate cell-line-specific effects on global protein synthesis, as determined by metabolic labeling.

133 defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term m

134 nsuming RS diets may have had depressed milk protein synthesis because these animals had decreased ca

135 is notion, post-reactivation pharmacological protein synthesis blockage results in mnemonic failure i

136 splay an overall inhibition in mitochondrial protein synthesis but rather have a problem in cytochrom

137 rophy was primarily driven by an increase in protein synthesis, but a reduction in ubiquitin-dependen

138 ompared to reloading alone, and myofibrillar protein synthesis, but not DNA synthesis, was also eleva

139 as transcription and both host and bacterial protein synthesis, but not urease, NapA, VacA, CagA, or

140 Translation is a critical process in protein synthesis, but translational regulation in antig

141 sponse pathways in bacteria, RelE shuts down protein synthesis by cleaving mRNA within the ribosomal

142 a role for casein kinase 2 in regulation of protein synthesis by downregulating stress granule forma

143 e demonstrating that optimal control of host protein synthesis by IAV PA-X and/or NS1 proteins is req

144 ggests that miscoding antibiotics may impact protein synthesis by impairing the recognition of peptid

145 active oxygen species generation, and matrix protein synthesis by inhibiting AMP-activated protein ki

146 tein kinase (AMPK) by low energy could limit protein synthesis by inhibiting mTORC1.

147 r of the unique alpha-kinase family, impedes protein synthesis by phosphorylating eEF-2.

148 ion of mTORC1-dependent pathways controlling protein synthesis can result in T-cell dysfunction, indi

149 ite widespread reductions in translation and protein synthesis, certain oncogenic mRNAs are spared.

150 Cell-free protein synthesis (CFPS) has the potential to produce en

151 o expression of this protein using cell-free protein synthesis (CFPS) technology in the presence of a

152 Here, we present an approach of cell-free protein synthesis (CFPS) that provides proteins with two

153 tegrative stress response to inhibit general protein synthesis coincident with preferential translati

154 monstrate the robust nature of the cell-free protein synthesis component in the presence of a variety

155 lism, increased protein degradation, reduced protein synthesis, decreased amino acid metabolism and d

156 , we show that trace fear memory undergoes a protein synthesis-dependent reconsolidation process foll

157 eemingly relies on their ability to activate protein-synthesis-dependent homeostatic mechanisms that

158 cytoplasm, and virus-induced shutoff of host protein synthesis downregulated the abundance of RNA5SP1

159 ilization involved transcription-independent protein synthesis driven by mitogen-activated protein ki

160 ing that this process is dependent on active protein synthesis during darkness.

161 Concurrent with reduced global protein synthesis, eIF2alpha-P and the accompanying inte

162 use these animals had decreased capacity for protein synthesis, enhanced proteolysis, inefficient ene

163 otypes in the Fmr1(-/y), including excessive protein synthesis, exaggerated mGluR-LTD, and audiogenic

164 , involved in cytoskeleton remodeling and in protein synthesis, folding and trafficking, key processe

165 Key proteins required for protein synthesis, folding, and degradation are also sub

166 The relationship between protein synthesis, folding, and disulfide formation with

167 or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance,

168 ehends a collection of mechanisms related to protein synthesis, folding, trafficking, secretion and d

169 The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation t

170 nd associates with polyribosomes to increase protein synthesis in a CAP-independent manner.

171 insights into the dynamics and regulation of protein synthesis in a cell.

172 y mechanism that dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates

173 However, regulation of local protein synthesis in developing axons remains poorly und

174 Efficient protein synthesis in eukaryotes requires diphthamide mod

175 n to be essential for accurate and efficient protein synthesis in eukaryotic cells.

176 uantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed

177 GA4-mRNA with SSB proteins resulted in ITGA4 protein synthesis in HEK293 cells only, whereas in MSCs,

178 he PA-X and NS1 proteins to inhibit the host protein synthesis in infected cells.

179 Local protein synthesis in mature axons may play a role in syn

180 xpected relationship between lipogenesis and protein synthesis in mitotic cell divisions.

181 SK inhibitors blocked cell proliferation and protein synthesis in multiple dual-resistant melanoma li

182 e mutation and promoted full-length SERPINB7 protein synthesis in NPPK keratinocytes.

183 ir ability to inhibit both proliferation and protein synthesis in patient-derived melanoma cell lines

184 of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle.

185 variant Def6 results in deregulation of Bcl6 protein synthesis in T cells as a result of enhanced act

186 The rate of protein synthesis in the adult heart is one of the lowes

187 l amino acid tagging (BONCAT) to interrogate protein synthesis in vegetative Arabidopsis (Arabidopsis

188 eIF2alphaP is required for induction of ATF4 protein synthesis in vivo in erythroid cells during ID.

189 ts derivatives have pleiotropic functions in protein synthesis including aminoacylation, decoding and

190 s ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memor

191 ly site formation even in the absence of new protein synthesis, indicating that the dissociated Gag m

192 fter disruption of original consolidation by protein synthesis inhibition (PSI) begun shortly after t

193 umulated in BCR-stimulated cells, leading to protein synthesis inhibition and cell cycle block.

194 Moreover, protein synthesis inhibition following early FOS express

195 of rapamycin inhibitor temsirolimus and the protein synthesis inhibitor anisomycin.

196 Here, we demonstrate that mefloquine is a protein synthesis inhibitor.

197 Here, we report that specific protein synthesis inhibitors could either significantly

198 Streptogramins A is a class of protein synthesis inhibitors that target the peptidyl tr

199 s can be directly modulated by commonly used protein synthesis inhibitors.

200 s venezuelae, represent minimalist macrolide protein synthesis inhibitors.

201 t aggressive human cancer cell lines and for protein synthesis inhibitory activity.

202 Protein synthesis is a key process in all living organis

203 n contribute to this rejuvenation, but local protein synthesis is also likely.

204 The extent to which local protein synthesis is conserved in human neurons is unkno

205 Protein synthesis is crucial for regulating cell homeost

206 We determine that global protein synthesis is elevated as a consequence of activa

207 ns cause host shutoff, a state in which host protein synthesis is globally inhibited.

208 When mTORC1 is inhibited, protein synthesis is reduced in an intricate process tha

209 ecessary for viral replication if continuous protein synthesis is required.

210 nger RNAs (mRNAs) engaged with ribosomes for protein synthesis, is still an elaborate procedure requi

211 P signalling causes sustained attenuation of protein synthesis, leading to memory impairment and neur

212 so revealed that individual cells with lower protein synthesis levels exhibited higher UGA readthroug

213 -a model of TS-rescues GSK3beta activity and protein synthesis levels, thus highlighting ERK1/2 as a

214 ly at precise subcellular locations by local protein synthesis (LPS) to facilitate localized growth r

215 asticity is the localization of RNAs and the protein synthesis machinery at synaptic sites.

216 nscription has been proposed to limit muscle protein synthesis, making ribosome biogenesis central to

217 Local protein synthesis occurs in axons and dendrites of neuro

218 , we present evidence that regulated de novo protein synthesis occurs within distal, perisynaptic ast

219 The metabolic function and protein synthesis of engineered liver scaffolds with hum

220 lear La/SSB into the cytoplasm, enhanced the protein synthesis of LAMB1 by activating its internal ri

221 antibody-toxin fusion proteins that inhibit protein synthesis of mammalian cells via ADP-ribosylatio

222 sylation activity and decisively affects the protein synthesis of the host cells.

223 Massage enhances protein synthesis of the myofibrillar and cytosolic, but

224 Muscle fibre cross sectional area and protein synthesis of the myofibrillar fraction, but not

225 od to enable precise addition of payloads to proteins, synthesis of antibody-drug conjugates, and ide

226 s that selectively target CaMKs and regulate protein synthesis offer novel strategies for treatment o

227 or interferon expression, downregulation of protein synthesis, or host cell death.

228 esses that each cause a rapid attenuation of protein synthesis: oxidative stress induced by hydrogen

229 s, intramuscular signaling, and myofibrillar protein synthesis.Plasma appearance rates of protein-der

230 Local axonal protein synthesis plays a crucial role in the formation

231 ed that a pathogen-mediated blockade of host protein synthesis provokes the production of specific pr

232 The paradigm protein synthesis rate is regulated by structural comple

233 ly, maintenance of the overall mitochondrial protein synthesis rate.

234 ensity along the mRNA and on the concomitant protein synthesis rate.

235 thesis rates or increase postprandial muscle protein synthesis rates after ingestion of 25 g protein

236 th HIGH PRO on basal and postprandial muscle protein synthesis rates after the ingestion of 25 g whey

237 PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.

238 tenance is largely regulated by basal muscle protein synthesis rates and the ability to increase musc

239 Protein synthesis rates are determined, at the translati

240 d show that, at high levels of reinitiation, protein synthesis rates are dominated by the time requir

241 lood samples were collected to assess muscle protein synthesis rates as well as dietary protein diges

242 tion, and termination/reinitiation-determine protein synthesis rates even at low ribosome availabilit

243 We measured protein synthesis rates from a reporter library of over

244 esponse plays a critical role in controlling protein synthesis rates in cells.

245 Muscle protein synthesis rates increased from 0.031% +/- 0.004%

246 Slower hindlimb linear growth and muscle protein synthesis rates match reduced hindlimb blood flo

247 circulation and does not lower basal muscle protein synthesis rates or increase postprandial muscle

248 ate slower hindlimb linear growth and muscle protein synthesis rates that match the reduced hindlimb

249 lls with low glucose uptake capacity and low protein synthesis rates were less ligand-sensitive, impl

250 the importance of codon usage in determining protein synthesis rates, and the negative correlation be

251 meric GTPase, which plays a critical role in protein synthesis regulation.

252 ibosome abundance, to reinitiate the de novo protein synthesis required for resuscitation.

253 amine-which goes far beyond satisfying their protein synthesis requirements-has only recently come in

254 of Atf4, BMP2 activates mTORC1 to stimulate protein synthesis, resulting in an endoplasmic reticulum

255 Simultaneous measurements of RN and protein synthesis revealed that these processes were lar

256 inding that loss of RH50 renders chloroplast protein synthesis sensitive to erythromycin and exposure

257 Inhibition of protein synthesis serves as a general measure of cellula

258 Identifying mechanisms that drive selective protein synthesis should facilitate understanding both v

259 While host protein synthesis shutoff benefits the virus by relocati

260 regulation in the context of an overall host protein synthesis shutoff to meet energy expenditure.

261 ANCE Many viral infections cause global host protein synthesis shutoff.

262 regulated during vaccinia virus-induced host protein synthesis shutoff.

263 Antimicrobial agents that inhibit protein synthesis such as macrolides, along with fluoroq

264 a reduction in Akt and p70s6k signaling and protein synthesis, suggesting a link between myonuclear

265 ion mechanism might selectively impact viral protein synthesis, suggesting that an NP-mediated transl

266 ding errors that suppress the termination of protein synthesis supports their potential as therapeuti

267 crucial in glutamine-deprived ECs to restore protein synthesis, suppress ER stress, and reactivate mT

268 ulted in greater stimulation of myofibrillar protein synthesis than did the ingestion of egg whites,

269 inactivate GSK3beta, resulting in increased protein synthesis that is independent of Akt/mTORC1 acti

270 During protein synthesis, the ribosome simultaneously binds up

271 nthesis with a concomitant increase in viral protein synthesis, though the mechanism by which the vir

272 d in plants and can in principle enter human protein synthesis through foods.

273 lating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR sig

274 s processes ranging from DNA replication and protein synthesis to cytoskeletal dynamics and cofactor

275 Here, we used cell-free protein synthesis to directly incorporate the hepatitis

276 own mature mRNA transport and thereby tailor protein synthesis to maintain energy homeostasis under s

277 the computational results, we used chemical protein synthesis to prepare three ShK polypeptide chain

278 oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth.

279 Creating long-term memory (LTM) requires new protein synthesis to stabilize learning-induced synaptic

280 hibition slows translation, thereby matching protein synthesis to the limited amino acid supply.

281 onine amino acid codons and genes related to protein synthesis, transport and degradation.

282 ovides insight in the human brain's regional protein synthesis, transport, and density, but also repr

283 amino acid biosynthesis, energy metabolism, protein synthesis, transport/binding, and transcriptiona

284 In eukaryotic cells, protein synthesis typically begins with the binding of e

285 ors for growth and proliferation, as well as protein synthesis via assembly of the 7-methyl-guanosine

286 Host protein synthesis was substantially suppressed in MACV-

287 amily member, Mcl-1, following inhibition of protein synthesis, we show for the first time that immun

288 UII-induced GMC proliferation and ECM protein synthesis were dependent on TRPC4 channel-mediat

289 t, mitochondrial dynamics, and mitochondrial protein synthesis were dysregulated.

290 osynthetic proteins and those of chloroplast protein synthesis were significantly lower in L. rostrat

291 ubunit is buried by the small subunit during protein synthesis, whereas that on the small subunit rem

292 of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part,

293 hosphorylation of mTORC1 substrates inhibits protein synthesis while activating autophagy.

294 erized by a progressive decrease in cellular protein synthesis with a concomitant increase in viral p

295 We measured new protein synthesis with O-propargyl-puromycin and L-homop

296 iated with decreased postprandial whole-body protein synthesis with RM than with FCM (40% compared wi

297 s uncover pervasive translational control of protein synthesis, with widespread alternative translati

298 course analysis revealed that C3P3 increased protein synthesis within the first 2 days of a reverse g

299 However, measurement of protein synthesis without consideration for cell prolife

300 nces suppression efficiency during cell-free protein synthesis, without significantly impacting cell