ライフサイエンスコーパス: protein targeting

1 ns ADEPTs (Additional Domains for Eukaryotic Protein Targeting).

2 ssential for the fidelity of cotranslational protein targeting.

3 n turnover, protein-protein interaction, and protein targeting.

4 kinetics of SRP-receptor interaction during protein targeting.

5 ites for both TF and SRP, in cotranslational protein targeting.

6 actions, in addition to performing a role in protein targeting.

7 , thus providing spatial coordination during protein targeting.

8 portant control points to drive and regulate protein targeting.

9 ic processes, possibly due to differences in protein targeting.

10 s as a model for studying multipass membrane protein targeting.

11 rther improve the efficiency and fidelity of protein targeting.

12 rate in several plant genes, often to expand protein targeting.

13 es to unload the cargo during late stages of protein targeting.

14 itical to cpFtsY function in cpSRP-dependent protein targeting.

15 tment, coupling GTP hydrolysis to productive protein targeting.

16 ms and physiological importance of bacterial protein targeting.

17 ycling of SRP and SR, but is not crucial for protein targeting.

18 is universally required for cotranslational protein targeting.

19 a novel link between E-cadherin and luminal protein targeting.

20 lead to GTPase activation are essential for protein targeting.

21 the transporter, whereas Pro-351 may affect protein targeting.

22 SRP-SR assembly and impairs cotranslational protein targeting.

23 egulatory processes, including intracellular protein targeting.

24 ant larvae, which is involved in basolateral protein targeting.

25 four pathways are responsible for thylakoid protein targeting.

26 ical approaches for the study of chloroplast protein targeting.

27 activities are not limited to unidirectional protein targeting.

28 polarized cell poses important questions of protein targeting.

29 icularly suited for studies of intracellular protein targeting.

30 P), useful in studies of gene expression and protein targeting.

31 e SRPs have been shown to play a key role in protein targeting.

32 nd NAC regulate each others' activity during protein targeting.

33 ein complex could function in translation or protein targeting.

34 efficiency and fidelity of co-translational protein targeting.

35 hich ensures accurate timing and fidelity of protein targeting.

36 elective cellular detection through membrane protein targeting.

37 to be more efficient than calcium-dependent protein targeting.

38 and neofunctionalization, and by changes in protein targeting.

39 ighted the semi-complementary, yet distinct, protein targeting.

40 to slow down the translation during membrane protein targeting.

41 go interaction drives efficient and faithful protein targeting.

42 sm employed by single viral immunomodulatory protein targeting a broad spectrum of cell surface molec

43 dings provide the first evidence of an F-box protein targeting a small G protein for ubiquitination a

44 data represent the first example of a viral protein targeting adherens junction proteins and suggest

45 mbined bioinformatics and fluorescent fusion protein targeting analysis.

46 tion of thylakoid-transfer signal removal on protein targeting and accumulation by examining the loca

47 Our increasing understanding of protein targeting and accumulation should further improv

48 Protein targeting and administration of stable isotope p

49 al di-amino acid motif in NS1 that modulates protein targeting and affected viral replication.

50 he CagA protein that play essential roles in protein targeting and alteration of host-cell signaling

51 ese data indicate that mechanisms underlying protein targeting and biogenesis of hydrogenosomes and m

52 role of endosome-based pathways in membrane protein targeting and cardiac physiology.

53 served and likely plays an important role in protein targeting and cell polarity.

54 s and regulation and serve critical roles in protein targeting and cellular signaling.

55 icle (SRP), responsible for co-translational protein targeting and delivery to cellular membranes, de

56 inal cytoplasmic domain of occludin controls protein targeting and endocytosis.

57 oteins often contain regions associated with protein targeting and enhanced translational termination

58 ds that are useful for protein purification, protein targeting and exploring protein-ligand interacti

59 ety of co-translational processes, including protein targeting and folding.

60 f use in many settings, including studies of protein targeting and folding.

61 lester at the carboxyl terminus and modulate protein targeting and function.

62 essential role for cholesterol in the apical protein targeting and further demonstrate that the mecha

63 translational endoplasmic-reticulum membrane protein targeting and insertion: a mechanism for reducin

64 assembly, membrane biogenesis, and signaling protein targeting and localization via as yet poorly und

65 ht to function in non-erythroid cells during protein targeting and membrane domain formation.

66 es basic questions about organelle assembly, protein targeting and metabolite transport.

67 in EspP(1-25) that abolished its effects on protein targeting and protein folding altered the cross-

68 ith UBL4A and GET4 and functions in membrane protein targeting and protein quality control.

69 quences for neuronal and epithelial membrane protein targeting and represents a novel cytoplasmic sig

70 nal recognition particle (SRP) takes part in protein targeting and secretion in all organisms.

71 hat a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts

72 h the lipid palmitate, is a key regulator of protein targeting and trafficking.

73 plant cells requires multiple mechanisms of protein targeting and trafficking.

74 ed between the classes, multiple pathways of protein targeting and translocation have been defined.

75 n the roles played by Tat signal peptides in protein targeting and translocation.

76 logical membranes plays an important role in protein targeting and transmembrane signaling.

77 is Bag6 complex is involved in tail-anchored protein targeting and various protein quality-control pa

78 n of peptides, 2D protein recrystallization, protein targeting, and biological sensing.

79 ractions inhibit VPS4 recruitment, lysosomal protein targeting, and HIV-1 budding.

80 role in intracellular vesicular trafficking, protein targeting, and other cellular processes.

81 aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors.

82 ection of drug-resistant viruses during core protein-targeting antiviral therapy.

83 The discovery of novel core protein-targeting antivirals, such as benzamide derivati

84 Within one of these two loci, protein targeting appeared to be plastidic when the 5' u

85 of the molecular mechanism of SRP-dependent protein targeting are conserved in all three kingdoms of

86 signal transduction pathway and establishes protein targeting as a mechanism that regulates signalin

87 erto unique entree into companion cell-to-SE protein targeting, as well as a new tool for studying wh

88 terized by the presence of nucleic acid- and protein-targeting autoantibodies and an aberrant type I

89 ct chaperone complexes in organelle-specific protein targeting between yeast and higher eukaryotes.

90 tisense-based knockdown protocols and fusion proteins targeting both proteins, we have shown that MsC

91 be involved not in light-harvesting complex protein targeting, but instead in the stabilization of t

92 e (lgl) and discs large (dlg) regulate basal protein targeting, but not apical complex formation or s

93 d on nuclear transcription and site-specific protein targeting, but the molecular mechanisms that coo

94 SRP RNA participates in the central step of protein targeting by catalyzing the interaction of the S

95 We studied RER protein targeting by expressing fluorescent protein fusi

96 le of such control occurs in cotranslational protein targeting by the signal recognition particle (SR

97 Cotranslational protein targeting by the signal recognition particle (SR

98 Protein targeting by the signal recognition particle (SR

99 During cotranslational protein targeting by the signal recognition particle (SR

100 hat this region is translated and influences protein targeting capacity.

101 Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD1

102 Fusion proteins targeting CD20 or tumor-associated glycoprotein

103 A chimeric compound, protein-targeting chimeric molecule 1 (Protac-1), was sy

104 de the first example of a viral transforming protein targeting Chk1 and provide important insights in

105 e molecular nature of the functional Get3-TA protein targeting complex remains unknown.

106 B3) is a well-known component of a thylakoid protein-targeting complex that interacts with the chloro

107 omal mRNA transport and its implications for protein targeting, complex assembly, and septin biology.

108 including transcription factors, E3 ligases, protein targeting components, and protein kinases, and v

109 ation of the autophagic/cytoplasm-to-vacuole protein-targeting components have revealed the essential

110 plast biogenesis at various steps: thylakoid protein targeting (cpSecE), chloroplast gene expression

111 t mutants defective for cytoplasm-to-vacuole protein targeting (cvt) and autophagy (apg) revealed sev

112 Cotranslational protein targeting delivers proteins to the bacterial cyt

113 grade trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy f

114 regulatory information and N- and C-terminal protein targeting domains.

115 fined flanking sequences around epitopes and protein targeting dramatically increased the efficacy of

116 ry, the trifunctional agents may find use as protein-targeting drugs and as probes for conformational

117 rasite exploits new or unusual mechanisms of protein targeting (e.g. post-secretory membrane insertio

118 geting sequences de novo as well as modulate protein targeting efficiency and function in response to

119 Intracellular protein targeting experiments demonstrated that FIS1b, b

120 ncodes a paralog of the well-known thylakoid protein targeting factor ALB3.

121 portant reversible modification that impacts protein targeting, folding, stability, and interactions

122 ovalent binders, achieving specific covalent protein targeting for biological studies and therapeutic

123 SRP; the precise role of this fingerloop in protein targeting has remained elusive.

124 Viral expression of zinc finger proteins targeting histone acetylation to the Cdk5 promo

125 N) responses at different levels, with viral proteins targeting IFN induction, signaling, and antivir

126 -interleukin-2 [IL-2]), a recombinant fusion protein targeting IL-2 receptor-expressing malignant T l

127 s, slow elongation is important for membrane protein targeting in E. coli, which utilizes mechanisms

128 Because the study of protein targeting in germ cells is hampered by the lack

129 tablished as a marker of gene expression and protein targeting in intact cells and organisms.

130 , these data support a model for basolateral protein targeting in mammalian epithelial cells dependen

131 osin II inhibits, actomyosin-dependent basal protein targeting in neuroblasts.

132 ve critical roles in endosome-based membrane protein targeting in other cell types.

133 ll growth, and vectorial processes including protein targeting in polarized cellular settings.

134 ught to discover novel pathways for membrane protein targeting in primary cardiomyocytes.

135 oplast-encoded protein, cytochrome f, and in protein targeting in the etioplast, a nonphotosynthetic

136 Basolateral membrane protein targeting in the pronephric duct epithelial cell

137 the two-faced guest--just as is observed for protein targeting in vivo--dictates the kinetic pathway

138 ologue; and (d) by its role in SRP-dependent protein targeting in vivo.

139 at have diverged by deletion and creation of protein targeting information.

140 An SRP/FtsY-like protein targeting/integration pathway in chloroplasts me

141 We conclude that protein targeting is a completely independent function o

142 Cotranslational protein targeting is a conserved process for membrane pr

143 We now show that rhoptry protein targeting is also dependent on a dileucine motif

144 that the basic mechanism of co-translational protein targeting is conserved between bacteria and mamm

145 Protein targeting is critical in all living organisms an

146 Protein targeting is essential for domain specialization

147 The specificity of polycomb group protein targeting is incompletely understood.

148 ution of membrane curvature to transmembrane protein targeting is unknown because of the numerous sor

149 tion, a key regulatory mechanism controlling protein targeting, is catalyzed by DHHC-family palmitoyl

150 rs via the mono-ubiquitination of the FANCD2 protein, targeting it to nuclear foci where it co-locali

151 understand and manipulate plant peroxisomal protein targeting, it is important to establish the univ

152 genetically modified to produce insecticidal proteins targeting Lepidopteran pests and is therefore o

153 trin-containing polycation, transferrin (Tf) protein targeting ligand, and siRNA.

154 or (SR), which together comprise a conserved protein targeting machine and mediate the cotranslationa

155 tion particle (SRP), a universally conserved protein targeting machine.

156 minus, presents major challenges to cellular protein targeting machineries.

157 alization is essential to cells and requires protein-targeting machineries to both effectively captur

158 a central component of the co-translational protein targeting machinery that binds to the N-terminal

159 SRP RNA is an indispensable component of the protein targeting machinery.

160 s on the Guided Entry of Tail-Anchored (Get) protein targeting machinery.

161 cate that the membrane carriers and membrane protein-targeting machinery of hydrogenosomes and mitoch

162 teins is mediated by a universally conserved protein-targeting machinery, the signal recognition part

163 We propose that Isu protein targeting may be particularly important when env

164 nt for viruses such as SV5, that express a V protein targeting mda-5 but do not encode antagonists su

165 mammalian cells, suggesting the KASH and SUN protein targeting mechanisms are conserved.

166 Protein targeting mechanisms in flagellated protozoan pa

167 Although evidence supports the use of common protein targeting mechanisms in the biogenesis of these

168 ymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should h

169 al studies using immunoadhesins suggest that protein targeting might be a useful approach for analyzi

170 hagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria into autophagosomes for

171 tin that is covalently attached to substrate proteins targeting most for degradation.

172 within the diverse and widespread TIM barrel proteins, targeting murine adenosine deaminase (mADA) th

173 Chaperones that mediate membrane protein targeting not only need to protect the nascent t

174 To understand better how protein targeting occurs in the human system, the human

175 knowledge, the first example of differential protein targeting of orthologs in eukaryotes and reveals

176 coid receptor labeled with green fluorescent protein, targeting of the receptor to response elements

177 TPase substrates and may correct mistakes in protein targeting or topogenesis.

178 ces in studies of the tail-anchored membrane protein targeting pathway, which revealed a network of c

179 substrate binding to downstream steps in the protein targeting pathway.

180 The signal recognition particle (SRP) protein-targeting pathway plays a pivotal role in membra

181 al recognition particle-independent (SND) ER protein-targeting pathway, as being necessary for expres

182 in SRP54, a key member of the cotranslation protein-targeting pathway, lead to syndromic neutropenia

183 y is achieved is not well understood for any protein-targeting pathway.

184 ndoplasmic reticulum membrane by a dedicated protein-targeting pathway.

185 rates for prokaryotic SRP-dependent membrane protein targeting pathways, from that of eukaryotic SRP

186 issue in the analysis of structured peptides/proteins targeting pharmaceutical or pharmacological uti

187 ALB4 and STIC2 both participate in thylakoid protein targeting, potentially for a specific subset of

188 The microtubule-associated protein targeting protein for Xenopus kinesin-like prote

189 rganisms and may act generally as an adapter protein, targeting proteins for regulated degradation.

190 ion of the key regulator of ciliary membrane protein targeting, Rab8.

191 e that sigma(32) localization results from a protein targeting reaction facilitated by the signal rec

192 During the protein targeting reaction, the 4.5S SRP RNA accelerates

193 ocalization and activation at the end of the protein targeting reaction.

194 hat EC and neuroendocrine cells share common protein targeting recognition signals or receptors.

195 we report novel mutations in the N-terminal protein targeting regions of CYP2E1 that markedly affect

196 Posttranslational protein targeting requires chaperone assistance to direc

197 Basal protein targeting requires microfilament and myosin func

198 ional database designed to represent data on protein targeting sequences, mutant signals, subcellular

199 The protein targeting signal recognition particle (SRP) path

200 te metabolism, vacuolar/lysosomal transport, protein targeting, sorting, and translocation, cell grow

201 ion initiation has acted in the evolution of protein targeting specificity for those proteins capable

202 or proteins responsible for these different protein targeting strategies are not known.

203 s investigation and the development of novel protein targeting strategies were required to bring this

204 S41, a gene required for vacuolar fusion and protein targeting, suggesting a role for Mot3 in the reg

205 gy, Ferrandez and Condemine describe a novel protein targeting system in the enteric phytopathogen, D

206 in-arginine translocation (Tat) pathway is a protein targeting system present in many prokaryotes.

207 We provide evidence for anintrinsic protein targeting system through visualization of mitoch

208 e of the similarities and differences of the protein-targeting systems of the three domains of life,

209 pectedly wide distribution of sortase-driven protein-targeting systems.

210 Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are n

211 be sets, effectors of RNAi, microarrays, and protein-targeting technologies.

212 sed to generate a highly specific six-finger protein targeting the ERBB-2 promoter.

213 says demonstrated that NocR is a DNA binding protein, targeting the 126-bp intergenic region between

214 decades, revealing multifunctional bioactive proteins targeting the host's hemostasis and immune syst

215 We show here that antibody-protamine fusion proteins targeting the human integrin lymphocyte functio

216 generated two monobodies, synthetic binding proteins, targeting the Prdm14 SET domain and demonstrat

217 ntral role vesicular trafficking occupies in protein targeting, the molecular coding of the trafficki

218 Consistent with a role for apo Ffh in protein targeting, the side chains of the empty active-s

219 During co-translational protein targeting, the signal recognition particle (SRP)

220 ddition to its traditional role in mediating protein targeting, the signal was found to play a surpri

221 ization, stability, signal transduction, and protein targeting; their interaction is critical for ery

222 roteins is to selectively conjugate cellular proteins, targeting them directly to lysosome.

223 system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation.

224 by promoting the ubiquitination of substrate proteins, targeting them for proteasomal degradation.

225 ling by cleavage and release of myofibrillar proteins, targeting them for ubiquitination and proteaso

226 perties, adds short peptide tags to abnormal proteins, targeting these proteins for proteolytic degra

227 e monoubiquitination of the FANCD2 and FANCI proteins, targeting these proteins to discrete nuclear f

228 ese proteins are known to promote autophagy, protein targeting to aggresomes, and the processing of p

229 Signal sequences function in protein targeting to and translocation across the endopl

230 on that chaperones play an important role in protein targeting to chloroplasts.

231 Studies of misfolded protein targeting to endoplasmic reticulum-associated de

232 vily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction.

233 Protein targeting to glycogen (PTG) enhances glycogen ac

234 We generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTG(OE

235 Protein targeting to glycogen (PTG) is a scaffolding pro

236 n of the protein phosphatase 1 (PP1) subunit protein targeting to glycogen (PTG) markedly enhances ce

237 Protein targeting to glycogen (PTG), also known as PPP1R

238 le-specific regulatory subunit (RGL) and the protein targeting to glycogen (PTG), are strikingly incr

239 overexpression of one member of the family, protein targeting to glycogen (PTG), causes large increa

240 g subunits of protein phosphatase-1, such as protein targeting to glycogen (PTG), direct the phosphat

241 One regulator of this phosphorylation is protein targeting to glycogen (PTG/R5), a scaffold prote

242 ressed in 3T3-L1 adipocytes (called PTG, for protein targeting to glycogen) was cloned and characteri

243 e glycogen-targeting proteins, G(L) and PTG (protein targeting to glycogen), as being encoded by Mlx-

244 eins and shows promise as a general tool for protein targeting to lipid vesicles and cellular membran

245 cognition particle-dependent cotranslational protein targeting to membrane, and mRNA catabolic proces

246 Cotranslational protein targeting to membranes is regulated by two GTPas

247 likely represents one mode of non-canonical protein targeting to MT.

248 l for parasite viability through its role in protein targeting to multiple locales and its interactio

249 the ankyrinG-binding motif is sufficient for protein targeting to nodes of Ranvier.

250 ane and the endosome; however, their role in protein targeting to other organelles is less clear.

251 threshold near 500 nM required for efficient protein targeting to peroxisomes.

252 oc159 family represent distinct pathways for protein targeting to plastids and are consistent with th

253 The results raise opportunities for F-box protein targeting to preserve mitochondrial function.

254 proteins is one basis for the selectivity of protein targeting to rafts.

255 n accessible system for the investigation of protein targeting to secondary endosymbiotic organelles.

256 nding module (CBM48) and are homologs of the PROTEIN TARGETING TO STARCH (PTST) protein; thus, we nam

257 at synthesises amylose, and the discovery of PROTEIN TARGETING TO STARCH1 (PTST1) that targets GBSS t

258 and (3) altered affinity of GBSS for binding PROTEIN TARGETING TO STARCH1-a protein that targets GBSS

259 tioning of organelles necessitates efficient protein targeting to the appropriate subcellular locatio

260 Protein targeting to the bacterial plasma membrane was g

261 signal-recognition particle (SRP)-dependent protein targeting to the bacterial plasma membrane, two

262 revent cell surface removal of CD4 by Nef or protein targeting to the canonical ubiquitination-depend

263 The accuracy of tail-anchored (TA) protein targeting to the endoplasmic reticulum (ER) depe

264 cognition complex) pathway for tail-anchored protein targeting to the endoplasmic reticulum (ER) has

265 okaryotes) are essential for cotranslational protein targeting to the endoplasmic reticulum in eukary

266 tion particle (SRP) and its receptor mediate protein targeting to the endoplasmic reticulum or to the

267 sensing the ribosome during cotranslational protein targeting to the endoplasmic reticulum.

268 te the biologically required specificity for protein targeting to the endoplasmic reticulum.

269 ts indicate that the basic signals mediating protein targeting to the ER lumen are conserved througho

270 cretory pathway is not required for membrane protein targeting to the Golgi complex, at least in inse

271 confirm the existence of a novel pathway for protein targeting to the IM.

272 ro assay we previously showed that efficient protein targeting to the INM depends on nucleotide hydro

273 ure kinetics and investigate requirements of protein targeting to the INM.

274 To identify the determinants of protein targeting to the inner envelope membrane (IM), w

275 yrosine-based sorting system, which mediates protein targeting to the lysosome-like rhoptry secretory

276 e has now been identified as a mechanism for protein targeting to the nucleolus.

277 lated region of C5aR mRNA in regulating C5aR protein targeting to the plasma membrane.

278 ses, including protein synthesis and vesicle/protein targeting to the plasma membrane.

279 sible role for SGs in cargo transport and/or protein targeting to the plasma membrane.

280 activation of Rab8, a key mediator of cargo protein targeting to the primary cilium.

281 e detailed understanding of the mechanism of protein targeting to the Tat pathway has been hampered b

282 nction; the actin cytoskeleton is intact and protein targeting to the vacuole is normal.

283 n with Sortin2, a biomodulator that promotes protein targeting to the vacuole, altered PI4P abundance

284 omologous N-protein interactions, and that P protein targeting to the viroplasm requires N-P protein

285 To study possible pathways of protein targeting to these membranes, we have investigat

286 s significantly to the challenge of studying protein targeting to various membrane sub-compartments w

287 id translation and its regulation, including protein targeting/translocation to thylakoid membrane vi

288 Proteinaceous complexes responsible for protein targeting/translocation/insertion into membranes

289 lipids, proteins, and other compounds and in protein targeting/transport.

290 During cotranslational protein targeting, two guanosine triphosphatase (GTPase)

291 Viral proteins targeting UDG, such as the bacteriophage protei

292 ental proteomic analyses followed by in vivo protein targeting validations.

293 f many therapeutic proteins, and attempts at protein targeting via the circulatory system (i.e., "mag

294 wo novel S. cerevisiae peroxins required for protein targeting via the PTS2 branch of peroxisomal bio

295 he forming vesicle is an important aspect of protein targeting via vesicular trafficking.

296 tic origin of this effect, similar rescue of protein targeting was also observed with mutant SRP rece

297 is that the favorable ablative properties of protein-targeting wavelengths rest on selective heating

298 ng roles for RanGTP/importin beta in ciliary protein targeting, we further investigated the effect of

299 One such approach is protein targeting, which is based on the application of

300 o, including 5' and 3' flanking elements and protein targeting within plant cells.