ライフサイエンスコーパス: protein targeting

1 ns ADEPTs (Additional Domains for Eukaryotic Protein Targeting).

2 efficiency and fidelity of co-translational protein targeting.

3 , thus providing spatial coordination during protein targeting.

4 portant control points to drive and regulate protein targeting.

5 ic processes, possibly due to differences in protein targeting.

6 s as a model for studying multipass membrane protein targeting.

7 rther improve the efficiency and fidelity of protein targeting.

8 rate in several plant genes, often to expand protein targeting.

9 es to unload the cargo during late stages of protein targeting.

10 itical to cpFtsY function in cpSRP-dependent protein targeting.

11 tment, coupling GTP hydrolysis to productive protein targeting.

12 ms and physiological importance of bacterial protein targeting.

13 ycling of SRP and SR, but is not crucial for protein targeting.

14 is universally required for cotranslational protein targeting.

15 a novel link between E-cadherin and luminal protein targeting.

16 lead to GTPase activation are essential for protein targeting.

17 the transporter, whereas Pro-351 may affect protein targeting.

18 egulatory processes, including intracellular protein targeting.

19 ant larvae, which is involved in basolateral protein targeting.

20 four pathways are responsible for thylakoid protein targeting.

21 ical approaches for the study of chloroplast protein targeting.

22 activities are not limited to unidirectional protein targeting.

23 polarized cell poses important questions of protein targeting.

24 icularly suited for studies of intracellular protein targeting.

25 P), useful in studies of gene expression and protein targeting.

26 e SRPs have been shown to play a key role in protein targeting.

27 nd NAC regulate each others' activity during protein targeting.

28 ein complex could function in translation or protein targeting.

29 hich ensures accurate timing and fidelity of protein targeting.

30 elective cellular detection through membrane protein targeting.

31 to be more efficient than calcium-dependent protein targeting.

32 and neofunctionalization, and by changes in protein targeting.

33 ighted the semi-complementary, yet distinct, protein targeting.

34 to slow down the translation during membrane protein targeting.

35 go interaction drives efficient and faithful protein targeting.

36 kinetics of SRP-receptor interaction during protein targeting.

37 ites for both TF and SRP, in cotranslational protein targeting.

38 actions, in addition to performing a role in protein targeting.

39 dings provide the first evidence of an F-box protein targeting a small G protein for ubiquitination a

40 data represent the first example of a viral protein targeting adherens junction proteins and suggest

41 mbined bioinformatics and fluorescent fusion protein targeting analysis.

42 tion of thylakoid-transfer signal removal on protein targeting and accumulation by examining the loca

43 Our increasing understanding of protein targeting and accumulation should further improv

44 Protein targeting and administration of stable isotope p

45 al di-amino acid motif in NS1 that modulates protein targeting and affected viral replication.

46 he CagA protein that play essential roles in protein targeting and alteration of host-cell signaling

47 ese data indicate that mechanisms underlying protein targeting and biogenesis of hydrogenosomes and m

48 role of endosome-based pathways in membrane protein targeting and cardiac physiology.

49 served and likely plays an important role in protein targeting and cell polarity.

50 inal cytoplasmic domain of occludin controls protein targeting and endocytosis.

51 oteins often contain regions associated with protein targeting and enhanced translational termination

52 ds that are useful for protein purification, protein targeting and exploring protein-ligand interacti

53 f use in many settings, including studies of protein targeting and folding.

54 ety of co-translational processes, including protein targeting and folding.

55 lester at the carboxyl terminus and modulate protein targeting and function.

56 essential role for cholesterol in the apical protein targeting and further demonstrate that the mecha

57 translational endoplasmic-reticulum membrane protein targeting and insertion: a mechanism for reducin

58 Our data demonstrate that: (a) Protein targeting and internalization mediated by either

59 assembly, membrane biogenesis, and signaling protein targeting and localization via as yet poorly und

60 ht to function in non-erythroid cells during protein targeting and membrane domain formation.

61 es basic questions about organelle assembly, protein targeting and metabolite transport.

62 in EspP(1-25) that abolished its effects on protein targeting and protein folding altered the cross-

63 ith UBL4A and GET4 and functions in membrane protein targeting and protein quality control.

64 quences for neuronal and epithelial membrane protein targeting and represents a novel cytoplasmic sig

65 nal recognition particle (SRP) takes part in protein targeting and secretion in all organisms.

66 hat a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts

67 plant cells requires multiple mechanisms of protein targeting and trafficking.

68 ed between the classes, multiple pathways of protein targeting and translocation have been defined.

69 logical membranes plays an important role in protein targeting and transmembrane signaling.

70 is Bag6 complex is involved in tail-anchored protein targeting and various protein quality-control pa

71 n of peptides, 2D protein recrystallization, protein targeting, and biological sensing.

72 ractions inhibit VPS4 recruitment, lysosomal protein targeting, and HIV-1 budding.

73 role in intracellular vesicular trafficking, protein targeting, and other cellular processes.

74 aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors.

75 ection of drug-resistant viruses during core protein-targeting antiviral therapy.

76 The discovery of novel core protein-targeting antivirals, such as benzamide derivati

77 Within one of these two loci, protein targeting appeared to be plastidic when the 5' u

78 of the molecular mechanism of SRP-dependent protein targeting are conserved in all three kingdoms of

79 signal transduction pathway and establishes protein targeting as a mechanism that regulates signalin

80 erto unique entree into companion cell-to-SE protein targeting, as well as a new tool for studying wh

81 terized by the presence of nucleic acid- and protein-targeting autoantibodies and an aberrant type I

82 ct chaperone complexes in organelle-specific protein targeting between yeast and higher eukaryotes.

83 tisense-based knockdown protocols and fusion proteins targeting both proteins, we have shown that MsC

84 be involved not in light-harvesting complex protein targeting, but instead in the stabilization of t

85 e (lgl) and discs large (dlg) regulate basal protein targeting, but not apical complex formation or s

86 d on nuclear transcription and site-specific protein targeting, but the molecular mechanisms that coo

87 SRP RNA participates in the central step of protein targeting by catalyzing the interaction of the S

88 We studied RER protein targeting by expressing fluorescent protein fusi

89 le of such control occurs in cotranslational protein targeting by the signal recognition particle (SR

90 Cotranslational protein targeting by the signal recognition particle (SR

91 Protein targeting by the signal recognition particle (SR

92 During cotranslational protein targeting by the signal recognition particle (SR

93 Silencing by Sir protein targeting can also be initiated at a telomere-pr

94 hat this region is translated and influences protein targeting capacity.

95 Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD1

96 Fusion proteins targeting CD20 or tumor-associated glycoprotein

97 A chimeric compound, protein-targeting chimeric molecule 1 (Protac-1), was sy

98 de the first example of a viral transforming protein targeting Chk1 and provide important insights in

99 e molecular nature of the functional Get3-TA protein targeting complex remains unknown.

100 B3) is a well-known component of a thylakoid protein-targeting complex that interacts with the chloro

101 omal mRNA transport and its implications for protein targeting, complex assembly, and septin biology.

102 including transcription factors, E3 ligases, protein targeting components, and protein kinases, and v

103 ation of the autophagic/cytoplasm-to-vacuole protein-targeting components have revealed the essential

104 plast biogenesis at various steps: thylakoid protein targeting (cpSecE), chloroplast gene expression

105 t mutants defective for cytoplasm-to-vacuole protein targeting (cvt) and autophagy (apg) revealed sev

106 Cotranslational protein targeting delivers proteins to the bacterial cyt

107 regulatory information and N- and C-terminal protein targeting domains.

108 fined flanking sequences around epitopes and protein targeting dramatically increased the efficacy of

109 ry, the trifunctional agents may find use as protein-targeting drugs and as probes for conformational

110 rasite exploits new or unusual mechanisms of protein targeting (e.g. post-secretory membrane insertio

111 geting sequences de novo as well as modulate protein targeting efficiency and function in response to

112 Intracellular protein targeting experiments demonstrated that FIS1b, b

113 ncodes a paralog of the well-known thylakoid protein targeting factor ALB3.

114 portant reversible modification that impacts protein targeting, folding, stability, and interactions

115 SRP; the precise role of this fingerloop in protein targeting has remained elusive.

116 N) responses at different levels, with viral proteins targeting IFN induction, signaling, and antivir

117 -interleukin-2 [IL-2]), a recombinant fusion protein targeting IL-2 receptor-expressing malignant T l

118 s, slow elongation is important for membrane protein targeting in E. coli, which utilizes mechanisms

119 Because the study of protein targeting in germ cells is hampered by the lack

120 tablished as a marker of gene expression and protein targeting in intact cells and organisms.

121 , these data support a model for basolateral protein targeting in mammalian epithelial cells dependen

122 osin II inhibits, actomyosin-dependent basal protein targeting in neuroblasts.

123 ve critical roles in endosome-based membrane protein targeting in other cell types.

124 ll growth, and vectorial processes including protein targeting in polarized cellular settings.

125 ught to discover novel pathways for membrane protein targeting in primary cardiomyocytes.

126 oplast-encoded protein, cytochrome f, and in protein targeting in the etioplast, a nonphotosynthetic

127 Basolateral membrane protein targeting in the pronephric duct epithelial cell

128 the two-faced guest--just as is observed for protein targeting in vivo--dictates the kinetic pathway

129 ologue; and (d) by its role in SRP-dependent protein targeting in vivo.

130 at have diverged by deletion and creation of protein targeting information.

131 An SRP/FtsY-like protein targeting/integration pathway in chloroplasts me

132 of weak promoter activity, visualization of protein targeting into the nucleus and various plastids,

133 We conclude that protein targeting is a completely independent function o

134 We now show that rhoptry protein targeting is also dependent on a dileucine motif

135 that the basic mechanism of co-translational protein targeting is conserved between bacteria and mamm

136 Protein targeting is critical in all living organisms an

137 Protein targeting is essential for domain specialization

138 The specificity of polycomb group protein targeting is incompletely understood.

139 ution of membrane curvature to transmembrane protein targeting is unknown because of the numerous sor

140 tion, a key regulatory mechanism controlling protein targeting, is catalyzed by DHHC-family palmitoyl

141 rs via the mono-ubiquitination of the FANCD2 protein, targeting it to nuclear foci where it co-locali

142 understand and manipulate plant peroxisomal protein targeting, it is important to establish the univ

143 trin-containing polycation, transferrin (Tf) protein targeting ligand, and siRNA.

144 or (SR), which together comprise a conserved protein targeting machine and mediate the cotranslationa

145 minus, presents major challenges to cellular protein targeting machineries.

146 alization is essential to cells and requires protein-targeting machineries to both effectively captur

147 a central component of the co-translational protein targeting machinery that binds to the N-terminal

148 SRP RNA is an indispensable component of the protein targeting machinery.

149 s on the Guided Entry of Tail-Anchored (Get) protein targeting machinery.

150 cate that the membrane carriers and membrane protein-targeting machinery of hydrogenosomes and mitoch

151 teins is mediated by a universally conserved protein-targeting machinery, the signal recognition part

152 We propose that Isu protein targeting may be particularly important when env

153 nt for viruses such as SV5, that express a V protein targeting mda-5 but do not encode antagonists su

154 mammalian cells, suggesting the KASH and SUN protein targeting mechanisms are conserved.

155 Protein targeting mechanisms in flagellated protozoan pa

156 Although evidence supports the use of common protein targeting mechanisms in the biogenesis of these

157 ymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should h

158 al studies using immunoadhesins suggest that protein targeting might be a useful approach for analyzi

159 hagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria into autophagosomes for

160 tin that is covalently attached to substrate proteins targeting most for degradation.

161 To understand better how protein targeting occurs in the human system, the human

162 knowledge, the first example of differential protein targeting of orthologs in eukaryotes and reveals

163 coid receptor labeled with green fluorescent protein, targeting of the receptor to response elements

164 substrate binding to downstream steps in the protein targeting pathway.

165 The signal recognition particle (SRP) protein-targeting pathway plays a pivotal role in membra

166 in SRP54, a key member of the cotranslation protein-targeting pathway, lead to syndromic neutropenia

167 ndoplasmic reticulum membrane by a dedicated protein-targeting pathway.

168 y is achieved is not well understood for any protein-targeting pathway.

169 rates for prokaryotic SRP-dependent membrane protein targeting pathways, from that of eukaryotic SRP

170 ALB4 and STIC2 both participate in thylakoid protein targeting, potentially for a specific subset of

171 The microtubule-associated protein targeting protein for Xenopus kinesin-like prote

172 rganisms and may act generally as an adapter protein, targeting proteins for regulated degradation.

173 ion of the key regulator of ciliary membrane protein targeting, Rab8.

174 e that sigma(32) localization results from a protein targeting reaction facilitated by the signal rec

175 During the protein targeting reaction, the 4.5S SRP RNA accelerates

176 ocalization and activation at the end of the protein targeting reaction.

177 hat EC and neuroendocrine cells share common protein targeting recognition signals or receptors.

178 we report novel mutations in the N-terminal protein targeting regions of CYP2E1 that markedly affect

179 Basal protein targeting requires microfilament and myosin func

180 ional database designed to represent data on protein targeting sequences, mutant signals, subcellular

181 The protein targeting signal recognition particle (SRP) path

182 te metabolism, vacuolar/lysosomal transport, protein targeting, sorting, and translocation, cell grow

183 ion initiation has acted in the evolution of protein targeting specificity for those proteins capable

184 or proteins responsible for these different protein targeting strategies are not known.

185 s investigation and the development of novel protein targeting strategies were required to bring this

186 S41, a gene required for vacuolar fusion and protein targeting, suggesting a role for Mot3 in the reg

187 gy, Ferrandez and Condemine describe a novel protein targeting system in the enteric phytopathogen, D

188 in-arginine translocation (Tat) pathway is a protein targeting system present in many prokaryotes.

189 e of the similarities and differences of the protein-targeting systems of the three domains of life,

190 pectedly wide distribution of sortase-driven protein-targeting systems.

191 Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are n

192 be sets, effectors of RNAi, microarrays, and protein-targeting technologies.

193 sed to generate a highly specific six-finger protein targeting the ERBB-2 promoter.

194 says demonstrated that NocR is a DNA binding protein, targeting the 126-bp intergenic region between

195 We show here that antibody-protamine fusion proteins targeting the human integrin lymphocyte functio

196 generated two monobodies, synthetic binding proteins, targeting the Prdm14 SET domain and demonstrat

197 ntral role vesicular trafficking occupies in protein targeting, the molecular coding of the trafficki

198 Consistent with a role for apo Ffh in protein targeting, the side chains of the empty active-s

199 During co-translational protein targeting, the signal recognition particle (SRP)

200 ddition to its traditional role in mediating protein targeting, the signal was found to play a surpri

201 ization, stability, signal transduction, and protein targeting; their interaction is critical for ery

202 roteins is to selectively conjugate cellular proteins, targeting them directly to lysosome.

203 system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation.

204 by promoting the ubiquitination of substrate proteins, targeting them for proteasomal degradation.

205 ling by cleavage and release of myofibrillar proteins, targeting them for ubiquitination and proteaso

206 perties, adds short peptide tags to abnormal proteins, targeting these proteins for proteolytic degra

207 e monoubiquitination of the FANCD2 and FANCI proteins, targeting these proteins to discrete nuclear f

208 Signal sequences function in protein targeting to and translocation across the endopl

209 on that chaperones play an important role in protein targeting to chloroplasts.

210 Studies of misfolded protein targeting to endoplasmic reticulum-associated de

211 Protein targeting to glycogen (PTG) enhances glycogen ac

212 We generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTG(OE

213 Protein targeting to glycogen (PTG) is a scaffolding pro

214 n of the protein phosphatase 1 (PP1) subunit protein targeting to glycogen (PTG) markedly enhances ce

215 Protein targeting to glycogen (PTG), also known as PPP1R

216 le-specific regulatory subunit (RGL) and the protein targeting to glycogen (PTG), are strikingly incr

217 overexpression of one member of the family, protein targeting to glycogen (PTG), causes large increa

218 g subunits of protein phosphatase-1, such as protein targeting to glycogen (PTG), direct the phosphat

219 One regulator of this phosphorylation is protein targeting to glycogen (PTG/R5), a scaffold prote

220 ressed in 3T3-L1 adipocytes (called PTG, for protein targeting to glycogen) was cloned and characteri

221 e glycogen-targeting proteins, G(L) and PTG (protein targeting to glycogen), as being encoded by Mlx-

222 eins and shows promise as a general tool for protein targeting to lipid vesicles and cellular membran

223 Cotranslational protein targeting to membranes is regulated by two GTPas

224 likely represents one mode of non-canonical protein targeting to MT.

225 l for parasite viability through its role in protein targeting to multiple locales and its interactio

226 the ankyrinG-binding motif is sufficient for protein targeting to nodes of Ranvier.

227 ane and the endosome; however, their role in protein targeting to other organelles is less clear.

228 threshold near 500 nM required for efficient protein targeting to peroxisomes.

229 oc159 family represent distinct pathways for protein targeting to plastids and are consistent with th

230 The results raise opportunities for F-box protein targeting to preserve mitochondrial function.

231 proteins is one basis for the selectivity of protein targeting to rafts.

232 n accessible system for the investigation of protein targeting to secondary endosymbiotic organelles.

233 nding module (CBM48) and are homologs of the PROTEIN TARGETING TO STARCH (PTST) protein; thus, we nam

234 tioning of organelles necessitates efficient protein targeting to the appropriate subcellular locatio

235 Protein targeting to the bacterial plasma membrane was g

236 signal-recognition particle (SRP)-dependent protein targeting to the bacterial plasma membrane, two

237 revent cell surface removal of CD4 by Nef or protein targeting to the canonical ubiquitination-depend

238 The accuracy of tail-anchored (TA) protein targeting to the endoplasmic reticulum (ER) depe

239 cognition complex) pathway for tail-anchored protein targeting to the endoplasmic reticulum (ER) has

240 okaryotes) are essential for cotranslational protein targeting to the endoplasmic reticulum in eukary

241 tion particle (SRP) and its receptor mediate protein targeting to the endoplasmic reticulum or to the

242 ts indicate that the basic signals mediating protein targeting to the ER lumen are conserved througho

243 cretory pathway is not required for membrane protein targeting to the Golgi complex, at least in inse

244 confirm the existence of a novel pathway for protein targeting to the IM.

245 ro assay we previously showed that efficient protein targeting to the INM depends on nucleotide hydro

246 ure kinetics and investigate requirements of protein targeting to the INM.

247 To identify the determinants of protein targeting to the inner envelope membrane (IM), w

248 yrosine-based sorting system, which mediates protein targeting to the lysosome-like rhoptry secretory

249 e has now been identified as a mechanism for protein targeting to the nucleolus.

250 ses, including protein synthesis and vesicle/protein targeting to the plasma membrane.

251 sible role for SGs in cargo transport and/or protein targeting to the plasma membrane.

252 lated region of C5aR mRNA in regulating C5aR protein targeting to the plasma membrane.

253 activation of Rab8, a key mediator of cargo protein targeting to the primary cilium.

254 e detailed understanding of the mechanism of protein targeting to the Tat pathway has been hampered b

255 nction; the actin cytoskeleton is intact and protein targeting to the vacuole is normal.

256 omologous N-protein interactions, and that P protein targeting to the viroplasm requires N-P protein

257 To study possible pathways of protein targeting to these membranes, we have investigat

258 To study possible pathways of protein targeting to these membranes, we have investigat

259 s significantly to the challenge of studying protein targeting to various membrane sub-compartments w

260 id translation and its regulation, including protein targeting/translocation to thylakoid membrane vi

261 Proteinaceous complexes responsible for protein targeting/translocation/insertion into membranes

262 lipids, proteins, and other compounds and in protein targeting/transport.

263 During cotranslational protein targeting, two guanosine triphosphatase (GTPase)

264 Viral proteins targeting UDG, such as the bacteriophage protei

265 ental proteomic analyses followed by in vivo protein targeting validations.

266 f many therapeutic proteins, and attempts at protein targeting via the circulatory system (i.e., "mag

267 wo novel S. cerevisiae peroxins required for protein targeting via the PTS2 branch of peroxisomal bio

268 he forming vesicle is an important aspect of protein targeting via vesicular trafficking.

269 tic origin of this effect, similar rescue of protein targeting was also observed with mutant SRP rece

270 is that the favorable ablative properties of protein-targeting wavelengths rest on selective heating

271 One such approach is protein targeting, which is based on the application of

272 o, including 5' and 3' flanking elements and protein targeting within plant cells.