ライフサイエンスコーパス: protein trafficking

1 her explore the role of glycosylation in EMV protein trafficking.

2 y gene transactivation and nucleocytoplasmic protein trafficking.

3 on photoreceptor development, function, and protein trafficking.

4 es to endosomal membranes and is involved in protein trafficking.

5 gment development through regulating ciliary protein trafficking.

6 c kinase on mitochondrial membrane apoptotic protein trafficking.

7 is to form microdomains involved in membrane protein trafficking.

8 reticulum-associated degradation (ERAD) for protein trafficking.

9 ein PCM1, that are implicated in centrosomal protein trafficking.

10 disruptions of cilia structure and membrane protein trafficking.

11 regulation involves perturbation of membrane protein trafficking.

12 receptors involved in vesicle formation and protein trafficking.

13 e specialized platforms involved in membrane protein trafficking.

14 act on infectious virus production and viral protein trafficking.

15 alization and was sensitive to inhibitors of protein trafficking.

16 and suggest a possible mechanism to regulate protein trafficking.

17 etic programming, cytoskeleton dynamics, and protein trafficking.

18 es with the plasma membrane, thus regulating protein trafficking.

19 PI4K2B have roles in intracellular lipid and protein trafficking.

20 le in photoreceptor structure, function, and protein trafficking.

21 in the Golgi apparatus, where PKD regulates protein trafficking.

22 vel function of calcineurin in digestion and protein trafficking.

23 a-arrestins coordinate signaling events with protein trafficking.

24 r abnormal synaptic overgrowth and defective protein trafficking.

25 role of LRP6 as a platform for intracellular protein trafficking.

26 g/repair, transcription, RNA metabolism, and protein trafficking.

27 s, chemopreventative effects, and effects on protein trafficking.

28 th binding to 14-3-3zeta, a key regulator of protein trafficking.

29 paB activation and possibly in intracellular protein trafficking.

30 e structures, indicating a general defect in protein trafficking.

31 se results define a new function for Rab2 in protein trafficking.

32 rst time that GTRAP3-18 is a regulator of ER protein trafficking.

33 eotoxic and oxidative stresses, and impaired protein trafficking.

34 into host cells, proteolytic processing and protein trafficking.

35 vides a framework for understanding cellular protein trafficking.

36 th CEP290 being a key mediator involved in G protein trafficking.

37 /beta-catenin signaling through an effect on protein trafficking.

38 y of protein complexes and the regulation of protein trafficking.

39 pulations and that they act to control motor-protein trafficking.

40 nhibited by virus-induced disruption of host protein trafficking.

41 regulation, protein degradation and membrane protein trafficking.

42 ossibly as a consequence of participating in protein trafficking.

43 important role in ExPortal organization and protein trafficking.

44 ncode factors involved in diverse aspects of protein trafficking.

45 tion of enzyme function, cell signaling, and protein trafficking.

46 th corresponding roles in cell signaling and protein trafficking.

47 light on how sumoylation regulates membrane protein trafficking.

48 ifferent Golgi subcompartments by retrograde protein trafficking.

49 -length CEP290, restoring normal cilia-based protein trafficking.

50 nal damage has been associated with aberrant protein trafficking.

51 mice to study photoreceptor ciliogenesis and protein trafficking.

52 t sorting as an autoregulatory mechanism for protein trafficking.

53 e of physiological epoxides in intracellular protein trafficking.

54 tures suggesting novel mechanisms of ciliary protein trafficking.

55 ource of information regarding intracellular protein trafficking.

56 g stress responses, apoptosis, immunity, and protein trafficking.

57 escribe a role for K33-polyubiquitination in protein trafficking.

58 ocesses, including synaptic transmission and protein trafficking.

59 ts that if therapeutic strategies to correct protein trafficking abnormalities can be developed, it m

60 Protein trafficking across membranes is an essential fun

61 r results pinpoint a role of this complex in protein trafficking across the CC to the outer segments,

62 ed by loss of VLC-PUFAs or by mutated ELOVL4 protein trafficking/aggregation.

63 raflagellar transport (IFT), a bidirectional protein trafficking along the cilium.

64 sed protein pseudokinase thought to regulate protein trafficking along the secretory pathway, and dem

65 ymorphism is suggested to lead to changes in protein trafficking although the mechanism is unclear.

66 regulates the functioning of Vps13, both in protein trafficking and actin cytoskeleton organization.

67 ur results offer new insights into HIV-1 Gag protein trafficking and activities and provide new poten

68 proteins offers new insights into HIV-1 Gag protein trafficking and activities and provides new pote

69 data show that glycine 553 is important for protein trafficking and are consistent with, but do not

70 ntified roles as modulators of transmembrane protein trafficking and autophagy is not known.

71 HDAC6 has critical roles in protein trafficking and autophagy, but its function in t

72 FTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung canc

73 al nucleotide binding domain restored proper protein trafficking and cell surface localization of mul

74 Mutations in key components of protein trafficking and cellular degradation machinery r

75 f I(Kv11.1) through interactions of abnormal protein trafficking and channel gating.

76 responses to biotic and abiotic challenges, protein trafficking and chromatin structure.

77 ults reveal the particular importance of the protein trafficking and clearance mechanisms, including

78 and ubiquitination regulate VEGF-induced TJ protein trafficking and concomitant vascular permeabilit

79 ng intracellular sorting mechanisms, such as protein trafficking and cytoskeletal assembly.

80 onal modification that dynamically regulates protein trafficking and degradation in response to synap

81 over a novel function of CRK1 in anterograde protein trafficking and elucidate the mechanistic role o

82 reviously shown to protect against defective protein trafficking and ER stress, partially reversed li

83 onarily conserved protein unit that controls protein trafficking and exocytosis.

84 g mutant, we show that HDLs correct impaired protein trafficking and folding induced by thapsigargin

85 ndogenous or expressed proteins, for imaging protein trafficking and for defining the molecular mecha

86 atty acids onto cysteine residues, regulates protein trafficking and function and is mediated by a fa

87 has a profound impact on spine dynamics and protein trafficking and function.

88 might function to regulate heterotrimeric G protein trafficking and G protein-coupled receptor-media

89 c compartments with functional roles in both protein trafficking and growth factor signal transductio

90 f3a, an anterograde motor critical for cilia protein trafficking and growth.

91 Myosin VI is found to play a key role in the protein trafficking and homeostasis of the Golgi complex

92 These results demonstrate that abnormal protein trafficking and impairment in MVB maturation in

93 The present experiments investigated protein trafficking and interactions among Plin, Atgl, a

94 2, and SorCS3) play pleiotropic functions in protein trafficking and intracellular and intercellular

95 ferent dominant-negative interactions govern protein trafficking and ion channel gating, and these ar

96 etabolism and requires machinery involved in protein trafficking and post-translational modifications

97 ntation and its effects on amyloid precursor protein trafficking and processing in AD, suggesting Gol

98 all unicellular organisms, yet the basis of protein trafficking and proteolytic modification in this

99 cation and signalling capacity, upregulating protein trafficking and secretion dynamically during inf

100 cosylation site but did not adversely affect protein trafficking and secretion.

101 atory cytokine production, and alteration of protein trafficking and secretion.

102 ling may arise, in part, from alterations of protein trafficking and secretion.

103 that the family members could be involved in protein trafficking and serve as cargo receptors.

104 iple cellular processes, including vesicular protein trafficking and signal transduction.

105 eir membrane association, and plays roles in protein trafficking and signaling.

106 lycosylation must occur in coordination with protein trafficking and sorting.

107 discoveries pointing to an important role in protein trafficking and sporozoite transmission that cou

108 physiological function of APP in regulating protein trafficking and suggest that intracellular traff

109 ditional roles of FLNa include regulation of protein trafficking and surface expression.

110 Nef SMR binds a cellular protein involved in protein trafficking and that inhibition of this interact

111 bnormal processing of DBH mRNA and defective protein trafficking and that this disease could be treat

112 0-fold by targeting genes that regulate both protein trafficking and the formation of melanosomes, in

113 ypothesis that dynamin is required for viral protein trafficking and thus has pleiotropic inhibitory

114 dditionally known to inhibit hsp90-dependent protein trafficking and to promote proteasomal degradati

115 veolin-1 (Cav-1) interacts with and mediates protein trafficking and various cellular functions.

116 e for wt-p53 in the control of intracellular protein trafficking and/or secreted protein stability.

117 lar mechanisms of cell division and membrane protein trafficking (and vice versa).

118 ranscription and regulation, cell signaling, protein trafficking, and actin cytoskeleton organization

119 including tumor suppression, transcription, protein trafficking, and degradation.

120 s and play critical roles in cell signaling, protein trafficking, and elaboration of complex molecule

121 ic transmission, integration and plasticity, protein trafficking, and gene transcription.

122 and tubulovesicular structures, accelerates protein trafficking, and impairs accurate glycosylation

123 isruption of ER lipid rafts, perturbation of protein trafficking, and initiation of ER stress.

124 al processes, including signal transduction, protein trafficking, and pathogen entry and egress.

125 We assessed its biophysical, protein trafficking, and pharmacological mechanisms in a

126 rtant events as receptor signaling, membrane protein trafficking, and protein interactions to the nex

127 processes, including transport, metabolism, protein trafficking, and protein translation.

128 establish the relation among a salt bridge, protein trafficking, and receptor activation.

129 thological mechanisms of exosome biogenesis, protein trafficking, and signal transduction, especially

130 levels of regulation facilitate INM-directed protein trafficking, and that proteins participating in

131 tein biosynthesis, phospholipid and membrane protein trafficking, and the cellular roles of phospholi

132 equired for ciliogenesis, retrograde ciliary protein trafficking, and the regulation of Gli2/Gli3 act

133 uction, we inhibited protein ubiquitination, protein trafficking, and the ubiquitin-proteasome system

134 e lysine ubiquitination and HBV replication, protein trafficking, and virion release.

135 include rate-limiting factors in metabolism, protein trafficking, and, intriguingly, synaptic vesicle

136 Compartmentalization and polarized protein trafficking are essential for many cellular func

137 is study is to determine the role of ArsS in protein trafficking as a component of acid acclimation.

138 Given the importance of parasitic membrane protein trafficking as well as protein degradation in th

139 a multidomain protein involved in lysosomal protein trafficking, as a modifier of alpha-syn accumula

140 eticulum (ER) is rate-limiting for secretory protein trafficking because protein folding/assembly occ

141 chanistically, EHD3 is critical for membrane protein trafficking, because EHD3-deficient myocytes dis

142 ibition of endosomal acidification abrogates protein trafficking between early and late endosomal com

143 I complex, which is critical for anterograde protein trafficking between endoplasmic reticulum and Go

144 ycin, implicates the involvement of ERS25 in protein trafficking between the ER and the Golgi.

145 the role of the COG complex in facilitating protein trafficking between the Golgi and ER and provide

146 d -2 (flotillins) are implicated in membrane protein trafficking but exactly how has been elusive.

147 eparately in different tissues for efficient protein trafficking, but we know little of how cell sign

148 PII) mediates the initial steps of secretory protein trafficking by assembling onto subdomains of the

149 mics and actin-dependent slit diaphragm (SD) protein trafficking by manipulating the expression of IN

150 nuclear localization sequence (NLS) mediated protein trafficking by measuring biomolecular dynamics w

151 in Trypanosoma brucei, regulates anterograde protein trafficking by phosphorylating Sec31.

152 ption of Kv11.1 channel synthesis (class 1), protein trafficking (class 2), gating (class 3), or perm

153 nesis require the exocyst, a conserved eight-protein trafficking complex that traffics ciliary protei

154 We previously showed that the exocyst, a protein trafficking complex, is essential for ciliogenes

155 rically, suggest that abnormal regulation of protein trafficking contributes to proliferation in mela

156 lvement in membrane deformation and cellular protein trafficking, could orchestrate autophagy-mediate

157 is a key enzyme that functions in endosomal protein trafficking, cytokinesis, and retroviral budding

158 te in cell signaling including intracellular protein trafficking, cytoskeletal dynamics, cell migrati

159 show that loss of ATP13A2 causes a specific protein trafficking defect, and that Atp13a2 null mice d

160 se phosphosites to alanine recapitulates the protein trafficking defects caused by Sec31 depletion.

161 owth factor signaling or ER stress caused by protein trafficking defects.

162 s relative to wild-type cells, indicative of protein trafficking defects.

163 host proteins involved in L domain-dependent protein trafficking) diminished extracellular enveloped

164 tivity or expression but results in impaired protein trafficking downstream of the inositol trisphosp

165 Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45

166 which upon internalization serves to follow protein trafficking during endocytosis.

167 tein degradation elements, identification of protein trafficking elements, discovery of short functio

168 protein COOH terminus (GIPC) is involved in protein trafficking, endocytosis, and receptor clusterin

169 eby affecting the endocytic vesicle-mediated protein trafficking events that destabilized the TJ barr

170 genesis of chloroplasts involves a series of protein trafficking events.

171 pretation of morphogen signals by regulating protein-trafficking events in target cells.

172 rates the importance of chaperonin-dependent protein trafficking for plant stem cell function.

173 bidopsis BEX5/RabA1b as a novel regulator of protein trafficking from a TGN/EE compartment to the pla

174 onent of both the COPII coat, which mediates protein trafficking from the endoplasmic reticulum to th

175 Protein trafficking from the ER to the Golgi, determined

176 ing GAG chain synthesis does not affect core protein trafficking from these cells.

177 nd SYM-4/WDR44 proteins, which are linked to protein trafficking, function as additional components o

178 as well as protein-protein interactions and protein trafficking functions.

179 Mutation of the protein-trafficking gene Hps6, known to impair the forma

180 as regulating key cellular processes such as protein trafficking, gene transcription, and signaling.

181 An RNA interference screen targeting protein trafficking genes in S2 cells revealed a require

182 cular machinery in the host cell that permit protein trafficking, harvesting of nutrients, and mechan

183 However, protein trafficking has clear potential uses for importa

184 potassium channel, novel mechanisms altering protein trafficking have been discovered.

185 eticulum (ER) stress and reduced ER-to-Golgi protein trafficking have been implicated, the exact mech

186 The mechanisms underlying COPII-mediated protein trafficking have been well defined, but the exte

187 ps) proteins, factors that mediate vesicular protein trafficking, have additional roles in regulating

188 and cellular mechanisms of retromer-mediated protein trafficking, highlighting key examples of retrom

189 a variety of biological processes, including protein trafficking, HIV and HCV infection/replication,

190 es; regulation of signaling transduction and protein trafficking, immunity and storage; and their pre

191 In the absence of Cdx2, defective protein trafficking impairs apical-basal transport and i

192 Impairments in protein trafficking in AFLD are likely a direct result o

193 arch programs describe a specialized mode of protein trafficking in cilia, reveal that genetic disrup

194 road requirement for clathrin in basolateral protein trafficking in epithelial cells.

195 proteins play critical roles in membrane and protein trafficking in eukaryotes.

196 roteins play a critical role in membrane and protein trafficking in eukaryotes.

197 mbrane events that regulate ciliary membrane protein trafficking in existing organelles.

198 EHD3 is a critical component of protein trafficking in heart and is essential for the pr

199 and CaV3.2 as substrates for EHD3-dependent protein trafficking in heart, provide in vivo data on en

200 Recent quantitative analyses of ribosomal protein trafficking in HeLa cells have revealed a promin

201 e little-understood mechanisms that regulate protein trafficking in infected cells.

202 ys demonstrated an increase in intercellular protein trafficking in kob1-3, including increased diffu

203 that Numb plays a part in the regulation of protein trafficking in other types of cilia.

204 Primary cilia regulate polarized protein trafficking in photoreceptors, which are dynamic

205 transferase (NMT), an enzyme responsible for protein trafficking in Plasmodium falciparum , the most

206 , actin-based mechanoenzyme that facilitates protein trafficking in Rab11a-specific recycling vesicle

207 entriolar satellites have been implicated in protein trafficking in relation to the centrosome and ci

208 dentifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and estab

209 is a Galpha subunit cofactor essential for G protein trafficking in sensory cilia.

210 nvestigation into the role and regulation of protein trafficking in the early embryo, as well as serv

211 rough its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the ce

212 ytosis and recycling, as well as in membrane protein trafficking in the somatodendritic and axonal co

213 lyzed a requirement for V-ATPase activity in protein trafficking in the yeast secretory pathway.

214 taining protein 3 (EHD3) with endosome-based protein trafficking in ventricular cardiomyocytes.

215 complex and Arf1 as major regulators of PCP protein trafficking in vivo.

216 ession of proteins involved in intracellular protein trafficking; in particular, the phenotype was pa

217 Active protein trafficking into and out of the nucleus is depen

218 ol and produces PI3P, has been implicated in protein trafficking, intracellular survival, and virulen

219 Endosomal protein trafficking is an essential cellular process tha

220 Endocytic protein trafficking is directed by sorting signals on ca

221 Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding

222 Protein trafficking is regulated by small GTPases.

223 structural domains and found that deficient protein trafficking is the dominant mechanism for all do

224 n also has nonproteolytic functions, such as protein trafficking, kinase and phosphatase activation,

225 TPase geranylgeranylation impairs monoclonal protein trafficking, leading to endoplasmic reticulum st

226 ns) implicated in the regulation of membrane protein trafficking, leukocyte recruitment, and adhesion

227 have been proposed for the regulation of EMV protein trafficking, little attention has been paid to N

228 logical processes and many components of the protein trafficking machinery are ubiquitous.

229 PTEX is a putative protein trafficking machinery responsible for the export

230 c tail of CD4 to components of the host-cell protein trafficking machinery.

231 hitherto unknown components of the endosomal protein trafficking machinery.

232 ions and that a role for this light chain in protein trafficking may be independent of the myosin II

233 e crystalloid organelle, and suggest a novel protein-trafficking mechanism to deliver PbSR to the ooc

234 been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites

235 r agents, ocular drug delivery vehicles, and protein trafficking modulators.

236 ether, these results indicate that targeting protein-trafficking molecules markedly increases melanom

237 mmaS) binding by ARF6, which participates in protein trafficking near the plasma membrane, including

238 Endosome-based protein trafficking of membrane-bound ion channels and t

239 tly of CETN2; however, mouse CETN2 regulates protein trafficking of olfactory cilia and participates

240 e, we examine the biochemical properties and protein trafficking of wild-type and mutant GPR56.

241 including multisubunit structures related to protein trafficking or mitochondrial function.

242 formation that directly relates structure to protein trafficking or to activation.

243 hat the core retromer, a complex involved in protein trafficking, participates in OB biogenesis, lipi

244 s underlying their biogenesis and associated protein trafficking pathways remains limited.

245 Protein-trafficking pathways are targeted here in human

246 mediates transcytosis and endosome-to-Golgi protein trafficking, plays a key role in Wnt signaling.

247 onse to osmotic stress, and altered membrane protein trafficking, predicting variant alleles that wor

248 -ranging functions, including involvement in protein trafficking, prevention of protein aggregation,

249 entalized signaling; however, unlike soluble protein trafficking, processes targeting integral membra

250 e expression, cell migrations, extracellular protein trafficking, proteolytic processing, and cross-l

251 tion causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency.

252 1) (two proteins that regulate intracellular protein trafficking) reduces GH receptor cell-surface ex

253 Melanoma cells depleted of either of the protein-trafficking regulators vacuolar protein sorting

254 Protein trafficking requires proper ion and pH homeostas

255 DHA selectivity seems to be dictated by the protein trafficking route, independent of the functional

256 Light-dark cycle-regulated protein trafficking serves as a mechanism to segregate r

257 nce suggests that ubiquitination serves as a protein trafficking signal in addition to its well chara

258 Maurer clefts are organelles essential for protein trafficking, sorting, and assembly of protein co

259 This unusual protein trafficking system involves long-known parasite-

260 s of Plasmodium falciparum assemble a unique protein trafficking system that targets parasite protein

261 In addition to their functions in protein trafficking, the Vps10 family proteins modulate

262 nd elucidate the mechanistic role of CRK1 in protein trafficking through regulation of the COPII subu

263 receptor and CaMKII activation, and involved protein trafficking through specific PDZ domains of GIRK

264 dies of Rpgr suggest a role in intracellular protein trafficking through the connecting cilia, the go

265 nofluorescence microscopy was used to assess protein trafficking through the connecting cilium and to

266 clarify the mechanisms of amyloid precursor protein trafficking through the endosomal system in norm

267 ASP proteins, alone or combined, accelerates protein trafficking through the Golgi membranes but also

268 The proper glycosylation of proteins trafficking through the Golgi apparatus depends

269 Proteins trafficking through the secretory pathway must

270 hroughput flow cytometry to detect real-time protein trafficking to and from the plasma membrane in l

271 Functionally, protein trafficking to and from the postsynaptic membran

272 been most commonly associated with enabling protein trafficking to and interaction with cellular mem

273 ibution of centriolar satellites involved in protein trafficking to centrosomes as well as cilia asse

274 As expected, mutations disrupting protein trafficking to cilia often disrupt protein traff

275 ajor challenge in the field is to understand protein trafficking to cilia.

276 Recently, Rab32 has been implicated in protein trafficking to melanosomes and shown to function

277 ls are insufficient to explain how polarized protein trafficking to subcellular domains is accomplish

278 It has been suggested that deficient protein trafficking to the cell membrane is the dominant

279 tinal epithelial cells through regulation of protein trafficking to the cell surface.

280 , as suggested by current models of parasite protein trafficking to the erythrocyte.

281 xonal morphology as well as of intracellular protein trafficking to the lysosome compartment, as a ph

282 II spectrin interaction with Arp1 and normal protein trafficking to the membrane.

283 g protein trafficking to cilia often disrupt protein trafficking to the OS and cause photoreceptor de

284 that microtubules play an important role in protein trafficking to the plasma membrane.

285 istically, we show that Ocrl1 is involved in protein trafficking to the primary cilia in an Rab8-and

286 ntracellular pathways selectively regulating protein trafficking to the synapse.

287 ggesting that TNO1 is required for efficient protein trafficking to the vacuole.

288 nd that enolase and Bor1p regulate selective protein trafficking to the vacuole.

289 There was no evidence of any of the Ank proteins trafficking to the nucleus.

290 Regulatory associations in membrane protein trafficking, turnover, and phosphorylation inclu

291 Modulation of protein trafficking via cell-surface signaling by bindin

292 s in normal fibroblasts, whereas anterograde protein trafficking was much less affected.

293 Intracellular protein trafficking was pharmacologically blocked in viv

294 Anterograde and retrograde protein trafficking was slower in cells overexpressing L

295 eyond Golgi-endoplasmic reticulum retrograde protein trafficking, we disrupted COPI functions in the

296 To gain insight into protein trafficking, we micrografted Arabidopsis thalian

297 of research linking dysfunction in membrane protein trafficking with human cardiovascular disease, e

298 lacking an aqueous core but share aspects of protein trafficking with secretory membrane compartments

299 Although numerous linear motifs that direct protein trafficking within cells have been identified, t

300 Ciliobrevins perturb protein trafficking within the primary cilium, leading t