ライフサイエンスコーパス: protein translation

1 c initiation factor 2alpha to inhibit global protein translation.

2 of translation factors to mRNA, and blocked protein translation.

3 ontrol for VEGF-D expression at the level of protein translation.

4 icroRNAs (miRNAs)--block gene expression and protein translation.

5 ces the fraction of viral genomes engaged in protein translation.

6 d 5'-untranslated region predicted to impair protein translation.

7 of SLC4A4 and CFTR mRNAs, thereby inhibiting protein translation.

8 anslocated proteins that interfere with host protein translation.

9 s a protein kinase involved in regulation of protein translation.

10 to be associated with reduced cap-dependent protein translation.

11 ons show loss-of-function effects and impair protein translation.

12 a uniquely selective reduction of cytosolic protein translation.

13 mpared with IL-5 and GM-CSF, with a focus on protein translation.

14 radation of misfolded proteins, and reducing protein translation.

15 and defects in both ribosome biogenesis and protein translation.

16 mycin (mTOR) pathway component that inhibits protein translation.

17 an aminoacyl-tRNA transferase needed during protein translation.

18 hrough ribosomal S6 kinase (RSK) and enhance protein translation.

19 IF2S1 or EIF2A), which affects regulation of protein translation.

20 bophagy activity to both nutrient supply and protein translation.

21 d cellular distribution of the machinery for protein translation.

22 n at multiple levels, including splicing and protein translation.

23 l insights into the regulatory mechanisms of protein translation.

24 control the speed and hence the fidelity of protein translation.

25 acellular NADH oxidoreductase activities and protein translation.

26 e incorporated either during or after mutant protein translation.

27 via ERK1/2 and Akt, to regulate the rate of protein translation.

28 rial energy production and the regulation of protein translation.

29 f the apoptotic response and upregulation of protein translation.

30 he homologous region of ZEB1 does not affect protein translation.

31 ved in the regulation of gene expression and protein translation.

32 ional modification that appears to influence protein translation.

33 ein (FMRP), control Dscam expression through protein translation.

34 d stress response (ISR) genes and reprograms protein translation.

35 transcription and enhanced overall cellular protein translation.

36 er transport, Casparian strip formation, and protein translation.

37 range of high-throughput gene expression and protein translation.

38 ol plasticity-related gene transcription and protein translation.

39 ink changes in neuronal firing to changes in protein translation.

40 ight help to contribute radiation energy for protein translation.

41 ivating transcription factor 4 signaling and protein translation.

42 mTOR is a major regulator of host protein translation.

43 he function of this protein in mitochondrial protein translation.

44 acy and nutrient starvation responses during protein translation.

45 ARABIDOPSIS AP2/ERF (ORA)59 independently of protein translation.

46 tion of 16 additional genes independently of protein translation.

47 ecules, which is the essential first step of protein translation.

48 ease of functional mRNA and highly efficient protein translation.

49 d function by regulating gene expression and protein translation.

50 cted signaling pathway, leading to increased protein translation.

51 have been shown to have a negative effect on protein translation.

52 eased by C3P3, suggesting a direct effect on protein translation.

53 -RNA incorporation, in addition to enhancing protein translation.

54 mic signaling pathways that control neuronal protein translation.

55 tion is important for cell motility by local protein translation.

56 t overproduction of transcripts required for protein translation.

57 nsport, metabolism, protein trafficking, and protein translation.

58 is an acetyltransferase toxin that inhibits protein translation.

59 ithin viral inclusions, which did not impair protein translation.

60 degradation of target mRNAs or inhibition of protein translation.

61 read mark-up, GFF3-based feature tracks and protein translations.

62 of the most important negative regulators of protein translation, 4E binding protein 1 (4E-BP1) binds

63 Because OCTR-1 downregulates protein translation activities, the OCTR-1 pathway could

64 the in vitro studies on the DB7 fusion gene, protein translation activity is decreased in the hippoca

65 that this tRNA complement could restore the protein translation activity of tRNA-depleted E. coli ly

66 onstituent of ribosomes and participating in protein translation, additional extraribosomal functions

67 /iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide

68 We also observed higher basal protein translation and an absence of DHPG-induced incre

69 ity and mechanical allodynia require de novo protein translation and are mediated by TRPV1 and oxidat

70 an alternative way for understanding altered protein translation and brain circuit excitability assoc

71 sensor of nutrients and energy, and controls protein translation and cell growth.

72 s) in association with neuronal development, protein translation and cytoplasm transportation.

73 Protein translation and degradation are critical for pro

74 reasing or decreasing mRNA expression and/or protein translation and degradation.

75 d synaptic scaling, a process which required protein translation and eukaryotic elongation factor-2 k

76 formation to biochemical characterization of protein translation and folding in T. thermophilus.

77 de highly sensitive and specific markers for protein translation and genome replication.

78 ion, thus establishing a direct link between protein translation and HSF1 activity.

79 unction (i.e. increased frameshifting during protein translation and hypersensitivity toward the eEF2

80 t elevating neural network activity requires protein translation and is dependent on fragile X mental

81 action of RA at inhibitory synapses requires protein translation and is mediated by a nontranscriptio

82 s-induced activation of dHSCs by restricting protein translation and levels of reactive oxygen specie

83 t indicate RNA folding demarcates regions of protein translation and likely affects microRNA-mediated

84 Here, we formulate a time-delay model of protein translation and mRNA degradation by systematical

85 echanism by which Gp1 mGluR and FMRP mediate protein translation and neural network activity, potenti

86 termine the mechanism by which FMRP mediates protein translation and neural network activity, we demo

87 l mechanism through which Gp1 mGluR mediates protein translation and neural plasticity.

88 e approach to study how the cell coordinates protein translation and nitrogen assimilation to optimiz

89 of a variety of RNA molecules that regulate protein translation and other cellular functions.

90 shed Ras(V12)-induced rRNA transcription and protein translation and prevented both the in vitro and

91 ant cancer cell lines converged on ribosomal protein translation and proteasomal protein degradation

92 lated via gene amplification, transcription, protein translation and protein stability.

93 icated that IRF5 re-expression inhibited HCV protein translation and RNA replication.

94 pe adenocarcinoma with elevated eIF4E-driven protein translation and squamous cell carcinoma marked b

95 (betaTrCP) and miR-21 to suppression of SKP2 protein translation and stability.

96 that interact with ezrin were implicated in protein translation and stress granule dynamics.

97 gh dynamic control of glucose uptake, global protein translation and transcriptional regulation.

98 same genome browser, along with gene models, protein translation and variation tracks.

99 How FMRP impacts synaptic protein translation and which mRNAs are most important f

100 ferentiation, likely due to perturbations in protein translation and/or stability rather than transcr

101 on of Dgkkappa, indirectly controls synaptic proteins translation and membrane properties by impactin

102 ns of capping are to promote mRNA stability, protein translation, and concealment from cellular prote

103 onal mutations affecting JAK/STAT signaling, protein translation, and epigenetic control, providing n

104 ture analogs also differed in suppression of protein translation, and expression of cyclin D1.

105 G(1) checkpoint, attenuates the recovery of protein translation, and impairs induction of NOXA, a me

106 tein response (UPR) that serves to attenuate protein translation, and increase protein refolding or d

107 have altered presynaptic function, enhanced protein translation, and increased levels of F-actin.

108 n harbor genes related to ribosome function, protein translation, and proteasomal degradation, wherea

109 l activity, inhibition of in vitro bacterial protein translation, and the effect of dimerization on t

110 pidation that is dependent on RNA synthesis, protein translation, and the methyltransferase activity

111 mTORC1 is critically involved in RNA-to-protein translation, and we found that the first alcohol

112 uple environmental cues to the regulation of protein translation are not well understood.

113 Antibiotics that inhibit protein translation are promising candidates for reposit

114 rticular interest as members function during protein translation, are essential for viability, and ar

115 eIF2A-phosphorylation-mediated inhibition of protein translation as a critical mediator of the antile

116 es eEF2 and regulates the elongation step of protein translation, as a major molecular substrate medi

117 kt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation

118 In vitro ADP-ribosylation and protein translation assays demonstrate that the resultin

119 Nutritional restriction leads to protein translation attenuation that results in the stor

120 ncluding cell proliferation, RNA processing, protein translation, autophagy, apoptosis and antiviral

121 combined Pax3 and Zic1 gain-of-function and protein translation blockade, we uncovered 25 Pax3 and Z

122 PIM inhibition decreased cap-dependent protein translation, blocked JAK-STAT signaling, and mar

123 ies not only suggest that Gib2 has a role in protein translation but also present Gib2 as a physical

124 depressant effects of ketamine require rapid protein translation, but not transcription, resulting in

125 RNAs) are small noncoding RNAs that regulate protein translation by binding to complementary target m

126 se findings we propose that p190A may affect protein translation by controlling the assembly of funct

127 applicable strategy for robustly controlling protein translation by integrating synthetic translation

128 PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosph

129 These EFs are GTPases that participate in protein translation by presenting aminoacylated-tRNAs to

130 and Akt in the stimulation of mTOR-dependent protein translation by the AT1 receptor using HEK293 and

131 Active protein translation can be assessed and measured using r

132 y active niche signaling integration and low protein translation capacity.

133 about 7 to 16% on the fraction of cytosolic protein translation carried out by ribosomes accessible

134 osomal RNA and core genes mainly involved in protein translation, catalysed new ideas for cellular ev

135 rthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress

136 r mitoribosome assembly impair mitochondrial protein translation, causing combined OXPHOS enzyme defi

137 f Rapamycin Complex 1 (mTORC1), reduction of protein translation, cell cycle arrest, and conservation

138 tochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabo

139 pathway in promoting morphine-induced spinal protein translation changes and associated morphine tole

140 s, epigenetic or transcriptional regulation, protein translation, circadian disruption, and interacti

141 MicroRNAs (miRNAs) are regulators of protein translation, comprising a group of more than 150

142 ontroversial, growing evidence suggests that protein translation control may play a crucial role.

143 Protein translation controlled through activation of mam

144 NPs by 6 different routes and high levels of protein translation could be measured using in vivo imag

145 F2alpha) phosphorylation, a key regulator of protein translation, could enhance HbF post-transcriptio

146 B-cell lymphoma, we report that by reducing protein translation, CR can reduce expression of the pro

147 ses of PEAK1-depleted PDAC cells, we defined protein translation, cytoskeleton organization, and cell

148 s developed to identify compounds modulating protein translation directed from the internal ribosome

149 ein synthesis was associated with diminished protein translation efficiency but, surprisingly, not wi

150 Refining protein translation efficiency by customizing ribosome b

151 ntribute to variability of mRNA stability or protein translation efficiency.

152 Data revealed that inhibition of protein translation eliminated the mGluR1-mediated inhib

153 res its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu).

154 lar functions, including genome maintenance, protein translation, energy conversion, and the antivira

155 suppression on mGluR1/5-dependent dendritic protein translation, enhancing mGluR1/5-dependent synapt

156 lated regions of the evolutionally conserved protein translation factor SUI1 gene and ribosomal prote

157 We report that the protein translation factor, eukaryotic translation initi

158 led ribosomal fractions identified ribosomal proteins, translation factors and RNA-binding proteins (

159 es in cells and identified several ribosomal proteins, translation factors, and mRNAs.

160 cations of psymberin uncoupled inhibition of protein translation from cytotoxicity, suggesting that p

161 2) Bcl-2 PPI analyses by imaging fluorescent protein translation from mRNA outputs.

162 gulatory process that determines the rate of protein translation from mRNA.

163 at in addition to the production of the A2AR protein, translation from an upstream, out-of-frame AUG

164 ation in stroke may regulate MetAP2-mediated protein translation giving calpains a larger role in the

165 m of cellular defense involving de novo NRF2 protein translation governed by the EF1a interaction wit

166 Gelonin, a plant-derived toxin that inhibits protein translation, has attracted much attention in thi

167 an RNA-binding protein that regulates local protein translation, has been shown to be enriched in NL

168 By preventing protein translation, HNP1 functions as a "molecular brak

169 telet mRNA is only associated with low-level protein translation; however, platelets have a unique me

170 ate that pools of transfer RNA available for protein translation impact on the configuration of epith

171 ivity while retaining the ability to inhibit protein translation in a cell-free in vitro assay can be

172 egulation of vimentin mRNA transcription and protein translation in a dose-dependent manner.

173 re, we present the first genome-wide view of protein translation in an IgG-producing CHO cell line, m

174 axonal damage, virus infection induces local protein translation in axons, and viruses likely exploit

175 dominant transcriptional effect of blocking protein translation in cancer cells was inactivation of

176 re used to study intracellular signaling and protein translation in cells activated with IL-3, GM-CSF

177 how that SQRD-1 is also required to maintain protein translation in H2S.

178 Multiple data implicate modulation of protein translation in longevity.

179 quirement for ribosomal frameshifting during protein translation in order to produce the polyprotein

180 ies, the innate immune system down-regulates protein translation in response to viral infection throu

181 nthetic Escherichia coli tRNAs could support protein translation in the cell-free system.

182 Adaptive changes in protein translation in the nervous system are thought to

183 memory consolidation by impairing requisite protein translation in the VHIPP.

184 In this study, we investigate protein translation in zebrafish models of CdLS.

185 ing protein (involved in local regulation of protein translation) in MB-V3 neurons impairs LTM.

186 ylation and desuppression of rapid dendritic protein translation, including BDNF (brain-derived neuro

187 ivation of the UPR results in a cessation of protein translation, increased chaperone expression, and

188 proteins and altered rates of mitochondrial protein translation, indicating a pivotal relationship b

189 pted by the peripheral administration of the protein translation inhibitor anisomycin it is reflected

190 support a role for anti-NOTCH1 therapies and protein translation inhibitor combinations in the treatm

191 The protein translation inhibitor cordycepin, injected at th

192 -bromo cAMP; (4) failure to be reversed by a protein translation inhibitor; (5) priming in females as

193 We also investigated the effect of protein translation inhibitors on the switch of mGluR fu

194 smic-nuclear shuttling protein important for protein translation initiation and both RNA processing a

195 Overall, this study provides evidence of protein translation initiation at noncanonical TISs and

196 Protein translation initiation is a tightly controlled p

197 Protein translation initiation is controlled by levels o

198 ntiviral protein that inhibits cap-dependent protein translation initiation via phosphorylation of eI

199 , including mRNA-binding proteins, ribosomal proteins, translation initiation factors and translation

200 These included ribosomal proteins, nucleolar proteins, translation initiation factors, helicases, and

201 ulum (ER) translocon complex, which mediates protein translation into the ER, and the coat protein co

202 dditional evidence that ensuring fidelity of protein translation is a major role of hydroxylation.

203 drives the search for new antimalarials, and protein translation is a promising pathway to target.

204 Protein translation is an energetically demanding proces

205 Localized protein translation is critical in many biological conte

206 However, since protein translation is energetically expensive and tight

207 are consistent with a model in which ongoing protein translation is in constant kinetic competition w

208 Protein translation is inhibited by the unfolded protein

209 Protein translation is initiated with methionine in euka

210 In contrast, global protein translation is not altered in wild-type animals

211 The function of UTRs in protein translation is well established.

212 itiation, a major rate-limiting step of host protein translation, is a critical target in many viral

213 is normally considered a protein involved in protein translation, is a morphogenic protein.

214 s the 3'UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity

215 In addition, to detect any changes in protein translation levels as a result of Xa21 gene expr

216 ble to phage display that would overcome the protein translation limitations of microorganisms.

217 ous transmission signals to the postsynaptic protein translation machinery through Ca(2+)-induced Ca(

218 profoundly influence gene transcription and protein translation machinery to change hematopoietic ce

219 The components of the cellular protein translation machinery, such as ribosomal protein

220 nd that "off- and reloading" distributes the protein translation machinery.

221 ith elongation factor 1A, a component of the protein translation machinery.

222 hock response, accompanied by attenuation of protein translation, massive protein aggregation, growth

223 ed phenotypes, (2) deregulated EIF2-mediated protein translation may represent a mechanism for vulner

224 Our results demonstrate that impaired protein translation mediated by poly-PR and poly-GR pept

225 nt temperature triggers metabolic changes in protein translation, mitochondrial protein synthesis, an

226 n-like growth factor-1, dietary restriction, protein translation, mitochondrial signaling) in a longi

227 wed elevated expression of the mitochondrial protein translation (MPT) gene pathway relative to tumor

228 mall GTPase and an associated local synaptic protein translation network in this process.

229 some have been instrumental in understanding protein translation, no such probes exist to study ribos

230 e find that glutamate treatments up-regulate protein translation not only in intact rat cortical neur

231 Whether protein translation occurs in the nucleus is contentious

232 mycin complex 1 by Akt resulted in increased protein translation of DNMT3a.

233 We reconstituted protein translation of Thermus thermophilus in vitro fro

234 which serves as a regulatory switch to turn protein translation on or off.

235 This will reveal the importance of localized protein translation on various cellular processes.

236 by base-pairing with mRNA targets to affect protein translation or mRNA stability.

237 ponse measurements related to proliferation, protein translation, or pathway inhibition.

238 addition, we found additional inhibition of protein translation owing to diminished mTORC1 (mammalia

239 x and ER homeostasis, which is essential for protein translation, pancreatic function, and cellular a

240 nse via activation of the Bip-PERK-eIF2alpha protein translation pathway.

241 Misregulation of protein translation plays a critical role in human cance

242 involved in ribosome biosynthesis and in the protein translation process.

243 gluconeogenesis, inflammatory responses, and protein translation processes.

244 eoformans was associated with alterations in protein translation rate and activation of several stres

245 NA fragments in the absence of NSun2 reduces protein translation rates and activates stress pathways

246 ellular variations in mRNA transcription and protein translation rates attributed to cell-to-cell dif

247 ritical for eEF-2K to appropriately regulate protein translation rates.

248 m, fatty acid and mycolic acid biosynthesis, protein translation, redox regulation and detoxification

249 cription regulation and mGluR5/FMRP-mediated protein translation regulation through coregulation of a

250 kinetoplastid-specific ribosomal features in protein-translation regulation, an essential step toward

251 multiple categories including regulation of protein translation, regulation of protease activity, an

252 model where age-dependent down-regulation of protein translation-related components contributes to ex

253 een host microRNAs and Plasmodium falciparum protein translation; remodeling of red cell cytoskeletal

254 (translation initiation factor eIF4E-binding protein) translation repressor protein Caf20, and the Go

255 ifying genome-wide levels of mRNA and active protein translation, respectively, we analyzed the respo

256 Finally, the inhibitor of protein translation reversed hyperalgesic priming only w

257 hat glutamine is both an energy source and a protein-translation rheostat that is responsive to WNT a

258 e, an antibiotic that inhibits mitochondrial protein translation, selectively eradicates CML LSCs bot

259 physiological and pathological processes of protein translation, signal transduction, immunity, lung

260 mmon inherited mutation located close to the protein translation start site that is thought to produc

261 Antisense inhibition of WT1 protein translation strongly reduced Aoc1 transcripts in

262 st likely complex cells with a sophisticated protein translation system and a DNA genome encoding hun

263 m mammalian cells, bacteria, and a cell-free protein translation system, we show that the SARM1-TIR d

264 her levels of eIF4A cap-binding activity and protein translation than IgM(+) B cells.

265 g protein (CPEB) mRNA, a master regulator of protein translation that coimmunoprecipitated with PKCep

266 d34 (Ppp1r15a) and triggered reactivation of protein translation that exacerbated intracellular reten

267 of riboswitches regulates the initiation of protein translation, the fate of whether an RNA message

268 emia/reperfusion also triggers a decrease in protein translation through activation of the unfolded p

269 Protein translation through eukaryotic initiation factor

270 PI-3K signaling is known to regulate protein translation through mTORC1-dependent phosphoryla

271 A recent study connects increased protein translation to activation of HSF1 in malignant c

272 response to diverse stresses shut down most protein translation to conserve energy and lead to rapid

273 Expression of the DB7 fusion gene may reduce protein translation to impair brain functions and thereb

274 family kinase signaling and m-Tor-dependent protein translation to locally cluster presynaptic and p

275 asmic reticulum (ER) stress, cells attenuate protein translation to prevent accumulation of unfolded

276 nature of Gag translocation from the site of protein translation to the inner leaflet of the plasma m

277 induces oxidative stress and interferes with protein translation, to ATRA sharply increases APL cell

278 Protein translation typically begins with the recruitmen

279 okaryotic ribosomal RNA and interfering with protein translation, ultimately resulting in bacterial c

280 vel function of p50 in its regulation of p53 protein translation under stress conditions.

281 hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in m

282 ion of ERK1/2 and Akt activity and stimulate protein translation via both Akt-mTOR-p70/85S6K and ERK1

283 novel working model of strong inhibition of protein translation via interactions of G4 with potentia

284 variety of cellular conditions and regulates protein translation via phosphorylation of the translati

285 ed a novel function of p50 in modulating p53 protein translation via regulation of the miR-190/PHLPP1

286 Consistent with this, global protein translation was diminished and autophagosome bio

287 DEBS1, substantial premature termination of protein translation was observed.

288 Moreover, HIF-1alpha protein translation was upregulated via activating the A

289 rget of rapamycin (mTOR), which governs most protein translation, was activated in rat spinal dorsal

290 somal rRNA and is required for mitochondrial protein translation, was markedly reduced in Gabpalpha-n

291 ns, BDNF-induced mTOR pathway activation and protein translation were blocked by calpain inhibition.

292 lts in defective GTP-dependent initiation of protein translation, which can be rescued by administrat

293 ribosome biogenesis is reflected in reduced protein translation, which is inversely correlated with

294 ed S6K and 4EBP1 phosphorylation to decrease protein translation, which slowed down cell growth and p

295 R) and reflected ARF-dependent impairment of protein translation, which was exaggerated by drug treat

296 y highlights a novel regulatory mechanism of protein translation with AUUUA motifs in the 3' UTR of m

297 Growing cells coordinate protein translation with metabolic rates.

298 Inhibiting protein translation with puromycin blocks miR-122-mediat

299 ow that HNP1 enters macrophages and inhibits protein translation without inducing the unfolded-protei

300 nd ribosome assembly, mRNA transcription and protein translation without intact cells.