ライフサイエンスコーパス: protein translocation

1 hat a single SecY molecule is sufficient for protein translocation.

2 brane defects and premature, cotranslational protein translocation.

3 fers new avenues of approach to the study of protein translocation.

4 nal phenotype that may link to defective rod protein translocation.

5 ogical properties such as cell signaling and protein translocation.

6 hal toxin is used as a model system to study protein translocation.

7 physical model to characterize transmembrane protein translocation.

8 ch the membrane barrier is maintained during protein translocation.

9 the plug, which moves out of the way during protein translocation.

10 t this specific dimer likely promotes active protein translocation.

11 carrying Phe427, a residue known to catalyze protein translocation.

12 isulfide cross-links under varying stages of protein translocation.

13 ng, transcriptional control, DNA repair, and protein translocation.

14 ceptor complex, triggering Tha4 assembly and protein translocation.

15 mo-mechanical cycle of this nanomotor during protein translocation.

16 iation into monomers is not necessary during protein translocation.

17 akoid transmembrane proton gradient to power protein translocation.

18 e of the disulfide bridge in the dynamics of protein translocation.

19 rt, indicating that trapping by Mia40 drives protein translocation.

20 block GTPase activation severely compromise protein translocation.

21 l peptide conformation prior to the onset of protein translocation.

22 facilitate substrate-selective modulation of protein translocation.

23 sertion and retraction that promote stepwise protein translocation.

24 rmembrane space harbors diverse pathways for protein translocation.

25 pid, we propose a model for co-translational protein translocation.

26 uggesting defective assembly of the TTSS and protein translocation.

27 face, which was normally active for in vitro protein translocation.

28 the chemomechanical cycle of SecA-dependent protein translocation.

29 findings to current models of SecA-dependent protein translocation.

30 e insertion and retraction cycle that drives protein translocation.

31 rate unfolding, gate opening in the 20S, and protein translocation.

32 cific manner to facilitate the initiation of protein translocation.

33 ggest that the SecA dimer dissociates during protein translocation.

34 losterically activate SecA for ATP-dependent protein translocation.

35 d Ydj1p was essential for post-translational protein translocation.

36 nsient and dissipated upon the completion of protein translocation.

37 red by ligands that it interacts with during protein translocation.

38 f course, at the phenylalanine clamp) during protein translocation.

39 uption of clamp opening or closure abolishes protein translocation.

40 tion and hereby acts as a chaperone for PORA protein translocation.

41 play key roles in the molecular mechanism of protein translocation.

42 and supports the Brownian ratchet model for protein translocation.

43 art of the trimeric Ssh1 complex involved in protein translocation.

44 el system for understanding the mechanism of protein translocation.

45 allow substrate binding and movement during protein translocation.

46 nt to more general features of Gram-positive protein translocation.

47 sting that this enzyme at least partly fuels protein translocation.

48 te protein O-mannosylation in the context of protein translocation.

49 thereby suggesting a mechanism for effector protein translocation.

50 in a translation-dependent manner to confer protein translocation.

51 Sec71-Sec72 subcomplex in post-translational protein translocation.

52 ein recycling, cell cycle modifications, and protein translocation.

53 a number of additional functions, including protein translocation.

54 ethod can be used to quantify drug-dependent protein translocations.

55 Protein translocation across and insertion into membrane

56 Protein translocation across and insertion into membrane

57 unity to explore the molecular mechanisms of protein translocation across biological membranes in pre

58 Among the pathways for protein translocation across biological membranes, the D

59 cell invasion by apicomplexan parasites, and protein translocation across membranes in bacteria.

60 ngs establish a novel type of self-sustained protein translocation across membranes revealing the mol

61 suggest a novel self-sustained mechanism of protein translocation across membranes with a lipidic me

62 of proteins from aggregates, facilitation of protein translocation across membranes, and more special

63 Work on these problems included the study of protein translocation across membranes, the analysis of

64 within the proteasome pathway, facilitating protein translocation across organellar membranes, and e

65 ecretory mechanism that is based upon direct protein translocation across plasma membranes.

66 Protein translocation across the bacterial cytoplasmic m

67 A is an ATPase and motor protein that drives protein translocation across the bacterial plasma membra

68 Post-translational protein translocation across the bacterial plasma membra

69 Toc75 is the channel for protein translocation across the chloroplast outer envel

70 Protein translocation across the cytoplasmic membrane is

71 s ATP and the proton motive force to mediate protein translocation across the cytoplasmic membrane.

72 A critical event in protein translocation across the endoplasmic reticulum i

73 sociated protein (TRAP) complex required for protein translocation across the endoplasmic reticulum m

74 Protein translocation across the ER membrane and N-glyco

75 The first step during protein translocation across the glycosomal membrane of

76 sense plastids are defective specifically in protein translocation across the inner envelope membrane

77 Protein translocation across the mitochondrial inner mem

78 a hydrophobic interactions thereby mediating protein translocation across the outer membrane by a 'ho

79 sequences and receptor proteins, followed by protein translocation across the peroxisomal membrane.

80 x and utilizing its ATPase activity to drive protein translocation across the plasma membrane.

81 proteins appears to remain at least through protein translocation across the pore membrane to the IN

82 reports that have provided new insights into protein translocation across the PV membrane, characteri

83 5 superfamily, whose members are involved in protein translocation across, or integration into, cellu

84 of Clostridium botulinum neurotoxins (BoNTs) protein-translocation across membranes was investigated

85 mutants with FAS-positive insertions retain protein translocation activity.

86 uter membrane, which is postulated to aid in protein translocation after translation.

87 hods utilize a sequential "n-step" model for protein translocation along ssDNA and enable quantitativ

88 An understanding of the mechanism of protein translocation along ssDNA requires pre-steady st

89 inetic experiments that can be used to study protein translocation along ssDNA, along with the advant

90 he finding that a folding mutant that allows protein translocation alters an amino acid at the C term

91 ontains a disulfide bond that is crucial for protein translocation and channel gating.

92 This "phi-clamp" structure was required for protein translocation and comprised the major conductanc

93 in can interact with other components of the protein translocation and folding machinery to influence

94 ity and, hence, are essential for organellar protein translocation and folding.

95 our current mechanistic understanding of ER protein translocation and general principles of regulato

96 hia coli to promote protein folding, support protein translocation and handle protein misfolding.

97 These data show that SecA can promote protein translocation and ion channel activities both wh

98 the signal peptide specificity and increases protein translocation and ion channel activities.

99 the signal sequence, is required for proper protein translocation and maturation, while the extended

100 ing how the translocon, which is the site of protein translocation and membrane insertion, decides wh

101 simulating the minute-timescale dynamics of protein translocation and membrane integration via the S

102 veal key mechanistic features of early-stage protein translocation and membrane integration via the S

103 a central component of cellular pathways for protein translocation and membrane integration.

104 tive and exhibited defects in Ssa1-dependent protein translocation and misfolded protein degradation.

105 al role for Magmas and DnaJC19 in organellar protein translocation and mitochondria biogenesis, where

106 ication, thus highlighting its importance in protein translocation and mitochondrial biogenesis.

107 roteins, suggesting unexpected roles for the protein translocation and modification machinery in mRNA

108 , glucosidase IIbeta and SEC63p, function in protein translocation and quality control pathways in th

109 (ClpC1), an AAA-ATPase chaperone involved in protein translocation and quality control.

110 ne the polypeptide path during SecA-mediated protein translocation and suggest a mechanism by which A

111 assess the fate of different transcripts on protein translocation and superoxide production in human

112 as a SP-binding drug to selectively inhibit protein translocation and to reversibly regulate the exp

113 rom mitochondrial membrane change, apoptotic protein translocation, and apoptosis.

114 eased Nrf2 messenger RNA expression, nuclear protein translocation, and DNA binding compared with wil

115 l involved in bacterial envelope biogenesis, protein translocation, and metabolism.

116 TP synthesis, respiration, solute transport, protein translocation, and other physiological processes

117 s represent a family of proteins involved in protein translocation, and they are present in all domai

118 ethal secA mutant, was inactive for in vitro protein translocation, and was poorly active for translo

119 tic cycle of ATP and how they are coupled to protein translocation are not well understood.

120 he subunit status of SecA changes during the protein translocation as well as studies designed to elu

121 onstrate the beta-arrestin-green fluorescent protein translocation assay is an important tool in the

122 By using a Cre/loxP-based protein translocation assay, we found that proteins tran

123 s evaluated using arrestin-green fluorescent protein translocation assays and confocal fluorescence m

124 is technique potentially allows detection of protein translocation at the single-cell level.

125 We show that protein translocation between cytoplasm and nucleus not

126 l models of the cell cycle which incorporate protein translocation between cytoplasm and nucleus.

127 s previously shown to impair Sec61-dependent protein translocation, but the underlying molecular mech

128 SecA facilitates bacterial protein translocation by its association with presecreto

129 We propose that InvE controls protein translocation by regulating the function of the

130 ed to C. burnetii effector proteins to study protein translocation by the Dot/Icm system.

131 Here, we examined the proposal that protein translocation can occur by means of a SecA monom

132 The complementation assay for protein translocation (CAPT) is derived from beta-galact

133 le for mediating the interaction between the protein translocation channel and the STT3A complex.

134 Toc75 is known to act as a protein translocation channel at the outer membrane of t

135 The protein translocation channel at the plastid outer envel

136 ether the SRP receptor (SR) locates a vacant protein translocation channel by interacting with the ye

137 mplex associates with the ribosome to form a protein translocation channel in the bacterial plasma me

138 Toc75 is postulated to form the protein translocation channel in the chloroplastic outer

139 Toc75 is a protein translocation channel in the outer envelope memb

140 een the open and closed conformations of the protein translocation channel maintains a balance betwee

141 olic cochaperone that associates with the ER protein translocation channel Sec61.

142 aryltransferase is localized adjacent to the protein translocation channel to catalyze co-translation

143 smic reticulum and facilitate opening of the protein translocation channel to the passage of substrat

144 The mammalian Sec61 complex forms a protein translocation channel whose function depends upo

145 ribosome-nascent chain complex (RNC) to the protein translocation channel.

146 the evolutionary origin of the chloroplastic protein translocation channel.

147 xes (RNCs) that display a signal sequence to protein translocation channels in target membranes.

148 plexes (RNCs) displaying signal sequences to protein translocation channels in the plasma membrane of

149 arch biosynthesis, fermentation, and plastid protein translocation common to plants and algae but lac

150 In bacteria, the SecYEG protein translocation complex employs the cytosolic ATPa

151 , the ribosome funnel and the channel of the protein translocation complex SecYEG are aligned.

152 presence of homologues to pea chloroplastic protein translocation components, Tic110 and Toc75, in b

153 eins, such as SNAREs, apoptosis factors, and protein translocation components.

154 embrane-bound SecA dimer is critical for the protein translocation cycle, although these results cann

155 h severe cold sensitivity and a Sec-specific protein translocation defect.

156 certain residues in the gating motif cause a protein translocation defect.

157 We highlight protein translocation defects across the endoplasmic ret

158 oles for maintaining proper protein folding, protein translocation, degradation of unfolded protein,

159 Moreover, HOCl impaired protein translocation early in the course of bacterial k

160 brane bias values, a substantial fraction of protein translocation events are detected.

161 mark the location of repeated T6SS-mediated protein translocation events between bacterial cells.

162 riggered calcium signaling and intracellular protein translocation events, respectively.

163 oteomic method that allows global mapping of protein translocation events.

164 hibited BAD (Bcl-2-associated death protein) protein translocation from the cell cytosol to the membr

165 omonas aeruginosa Exotoxin A, which inhibits protein translocation from the ER to the cytosol, abroga

166 In contrast, dynamin-2 facilitates Fas protein translocation from the Golgi apparatus via the t

167 Our data also provide clear evidence for the protein translocation function of Omp85 transporters.

168 ed to maintain essential functions including protein translocation, glycosylation, degradation, and t

169 nsertion and retraction at SecYEG that drive protein translocation in a stepwise fashion.

170 P-driven conformational changes that promote protein translocation in a stepwise manner.

171 els with only one active pore likely mediate protein translocation in all organisms.

172 machinery constitutes the major pathway for protein translocation in bacteria.

173 luorescent imaging of Arr2-green fluorescent protein translocation in dissociated ommatidia, we show

174 Protein translocation in Escherichia coli is initiated b

175 The SecA nanomotor promotes protein translocation in eubacteria by binding both prot

176 of guanylate cyclase 1 (GC1) on light-driven protein translocation in rod and cone cells.

177 report on the dynamics of transcription and protein translocation in single cells.

178 ptide interaction is critical for initiating protein translocation in the bacterial Sec-dependent pat

179 The role of VIPP1 in protein translocation in the chloroplast has not been in

180 Examples include protein translocation in the endoplasmic reticulum and t

181 on of calmodulin specifically impaired small-protein translocation in vitro and in cells.

182 ting their interactions to promote efficient protein translocation in vivo.

183 gest that SecA functions as a monomer during protein translocation in vivo.

184 Post-translational protein translocation in yeast requires both the Sec61 t

185 lity to identify inhibitors of mitochondrial protein translocation in yeast validates the generation

186 Furthermore, Yme1 has a new function in protein translocation, indicating that the intermembrane

187 rotein EspD, which is essential for effector protein translocation into host cells.

188 ity of reporter systems to monitor bacterial protein translocation into host cells.

189 Alder et al. examine protein translocation into intact mitochondria by adapti

190 how that SecA alone is sufficient to promote protein translocation into liposomes and to elicit ionic

191 We previously reported that Tat-dependent protein translocation into membrane vesicles of Escheric

192 Tim23 mediates protein translocation into mitochondria.

193 We propose a model to study protein translocation into the chamber of biological unf

194 mechanisms regulating secretory and membrane protein translocation into the endoplasmic reticulum (ER

195 accurately measuring the in vivo fidelity of protein translocation into the endoplasmic reticulum (ER

196 Protein translocation into the endoplasmic reticulum is

197 nd the translocon leads to the initiation of protein translocation into the endoplasmic reticulum lum

198 be cotransin, a small molecule that inhibits protein translocation into the endoplasmic reticulum.

199 gnition by the machinery for cotranslational protein translocation into the ER.

200 provide strong evidence for PTEX function in protein translocation into the host cell.

201 nner mitochondrial membrane, is critical for protein translocation into the matrix.

202 s of MURA and MURB can occur at the level of protein translocation into the nucleus, a cytoplasmicall

203 However, protein translocation involves oligomers of the SecY com

204 Thus, protein translocation is a physiologically regulated pro

205 Cotranslational protein translocation is a universally conserved process

206 Protein translocation is also critical for microbial pat

207 ng the molecular mechanisms of mitochondrial protein translocation is crucial for understanding the i

208 basis of this information, the evolution of protein translocation is discussed.

209 Light-driven protein translocation is responsible for the dramatic re

210 however, its oligomeric state during active protein translocation is still unresolved.

211 er-stroke and brownian-ratchet mechanisms of protein translocation is the process through which noneq

212 Among the various protein-translocation machineries, the peptidase-contain

213 brane and secretory proteins to the cellular protein translocation machinery during translation.

214 SecDF is an important component of the Sec protein translocation machinery embedded in the bacteria

215 ations in SEC63, encoding a component of the protein translocation machinery in the ER, also cause th

216 tation in a basic component of the cell's ER protein translocation machinery, Sec61alpha1.

217 or is a central component of the eubacterial protein translocation machinery.

218 complex SecYEG form the core of an essential protein translocation machinery.

219 with the SRP receptor, delivers them to the protein-translocation machinery on the target membrane.

220 in vitro lipid binding analyses and cellular protein translocation measurements.

221 mass as plastidial HMR, support a retrograde protein translocation mechanism in which HMR is targeted

222 ggest that the colicin channel has a general protein translocation mechanism.

223 ous studies have proposed that, unlike other protein translocation mechanisms, Yops are not recognize

224 families of effector proteins containing the protein translocation motif RXLR-dEER.

225 scence (enhanced green fluorescent protein), protein translocation (nuclear localization sequence), D

226 tent, to the inner segments, where polarized protein translocation occurs.

227 transcriptional regulation and intra-nuclear protein translocation of FoxM1 in polyploid cells, respe

228 Kinetic characterizations of protein translocation on DNA are nontrivial because the

229 ion, whereas others appear to be involved in protein translocation or in ribosomal RNA processing and

230 ient transthylakoid proton gradient to drive protein translocation or other processes.

231 an essential component of the Sec-dependent protein translocation pathway across cytoplasmic membran

232 an essential component in the Sec-dependent protein translocation pathway and, together with ATP, pr

233 re essential components of the twin arginine protein translocation pathway in Escherichia coli.

234 The Sec-dependent protein translocation pathway promotes the transport of

235 esponse is coupled with the co-translational protein translocation pathway to maintain protein homeos

236 at functions in bacterial post-translational protein translocation pathway.

237 the compatibility and regulation of multiple protein translocation pathways that each makes distinct

238 Protein translocation presumably occurs through a protei

239 igomeric state of functional SecA during the protein translocation process is controversial.

240 at induced robust betaarr2-green fluorescent protein translocation produced similar analgesia profile

241 d unbinding rate parameters that balance the protein translocation rate and the efficiency of the sea

242 of SecA could change dynamically during the protein translocation reaction.

243 We propose that regulation of protein translocation represents a potentially general m

244 Because efficient protein translocation requires at least a 100-fold accel

245 ec and signal recognition particle-dependent protein translocation, respectively.

246 wn whether they can be exploited to modulate protein translocation selectively.

247 h178 seems to occur prior to SEC61-dependent protein translocation, since inhibition of MHC-I translo

248 charged residues play a critical role in the protein translocation step that follows TatA assembly.

249 Traditionally, in vitro protein translocation studies have been performed using

250 e increased by ER stress and diminished when protein translocation substrates were depleted.

251 The twin-arginine protein translocation system (Tat) transports folded pro

252 he toxin component of the phage tail-derived protein translocation system Afp, which causes enteric r

253 r components of the Eubacteria Sec-dependent protein translocation system are the heterotrimeric chan

254 The bacterial Sec protein translocation system catalyzes the transport of

255 d to the host cytosol by the Dot/Icm type IV protein translocation system during infection.

256 he dispensability of the cotranslational SRP protein translocation system in a bacterium.

257 ereby S-motility reversals are mediated by a protein translocation system that delivers motility prot

258 The Escherichia coli Tat apparatus is a protein translocation system that serves to export folde

259 Legionella pneumophila requires the Dot/Icm protein translocation system to replicate within host ce

260 lipids that, in the absence of a specialized protein translocation system, appear to constitute the m

261 nt with recent structural insights into this protein translocation system.

262 experiments that defined the SecY-dependent protein translocation system.

263 of this vacuole requires the Dot/Icm type IV protein translocation system.

264 Protein translocation systems consist of complex molecul

265 teria, are members of a large superfamily of protein translocation systems that are widely distribute

266 General chaperones are common components of protein translocation systems where they maintain cargo

267 erspectives in studies of phage tail-derived protein translocation systems, which are preserved from

268 be found in, and may be important for, other protein translocation systems.

269 lationship similar to that observed in other protein translocation systems.

270 The thylakoid twin arginine protein translocation (Tat) system is thought to have a

271 The twin-arginine protein translocation (Tat) system mediates transport of

272 The thylakoid twin arginine protein translocation (Tat) system operates by a cyclica

273 We develop a reaction-diffusion theory of protein translocation that accounts for transport both o

274 the precise sequence of events that leads to protein translocation, the energetic requirements, or th

275 roove are shown to have a dramatic effect on protein translocation through the ClpB central pore, sug

276 standing of the ATP power stroke that drives protein translocation through the ClpB hexamer.

277 gical studies to form a clamp that catalyzes protein translocation through the pore.

278 SecA plays a critical role in protein translocation through the SecYEG membrane channe

279 his disulfide bond is critical for efficient protein translocation through the TIM23 complex and for

280 pose a repulsive electrostatic mechanism for protein translocation through the type III secretion app

281 n motive force could be used to energize the protein translocation through these nanomachines.

282 The findings further suggest that protein translocation to the cell envelope is one import

283 -2A is a transmembrane protein component for protein translocation to the lysosome.

284 transmission and at the inner segment during protein translocation to the outer segment.

285 s shown by defects in ATRIP (ATR-interacting protein) translocation to sites of UV damage, UV-induced

286 EGF stimulated HDAC6 enzymatic activity and protein translocation toward the leading edge of the cel

287 trate the utility of this system by inducing protein translocation, transcription and Cre recombinase

288 Protein translocation under a proton motive force is cat

289 RP-ribosome nascent chain complex to promote protein translocation under physiological ionic strength

290 scribe a method for quantitatively assessing protein translocation using proximity-induced enzyme com

291 427 residues of protective antigen catalyses protein translocation via a charge-state-dependent Brown

292 nsistent with its proposed role in enhancing protein translocation via Tat.

293 The free energy cost of protein translocation via the chloro-plast DeltapH-depen

294 oding a highly conserved ATPase required for protein translocation via the flagellar type III secreti

295 ity cup to localize secretion substrates for protein translocation via the flagellar-specific type II

296 the regulation of Sec-mediated pathways for protein translocation vs. membrane integration are discu

297 nsight into the mechanism of autotransporter protein translocation, we performed a structure-function

298 these are the first studies on Tat-dependent protein translocation where both oxidative folding and c

299 assessing rod tet-ARR1 and its reduction via protein translocation, which can be combined with other

300 We applied this analysis to protein translocations within long DNA molecules.