ライフサイエンスコーパス: protein translocation

1 in a translation-dependent manner to confer protein translocation.

2 ein recycling, cell cycle modifications, and protein translocation.

3 a number of additional functions, including protein translocation.

4 hat a single SecY molecule is sufficient for protein translocation.

5 brane defects and premature, cotranslational protein translocation.

6 fers new avenues of approach to the study of protein translocation.

7 nal phenotype that may link to defective rod protein translocation.

8 hal toxin is used as a model system to study protein translocation.

9 physical model to characterize transmembrane protein translocation.

10 ch the membrane barrier is maintained during protein translocation.

11 the plug, which moves out of the way during protein translocation.

12 carrying Phe427, a residue known to catalyze protein translocation.

13 isulfide cross-links under varying stages of protein translocation.

14 ng, transcriptional control, DNA repair, and protein translocation.

15 ceptor complex, triggering Tha4 assembly and protein translocation.

16 mo-mechanical cycle of this nanomotor during protein translocation.

17 iation into monomers is not necessary during protein translocation.

18 akoid transmembrane proton gradient to power protein translocation.

19 e of the disulfide bridge in the dynamics of protein translocation.

20 block GTPase activation severely compromise protein translocation.

21 c insights into eukaryotic posttranslational protein translocation.

22 l peptide conformation prior to the onset of protein translocation.

23 facilitate substrate-selective modulation of protein translocation.

24 sertion and retraction that promote stepwise protein translocation.

25 rmembrane space harbors diverse pathways for protein translocation.

26 pid, we propose a model for co-translational protein translocation.

27 uggesting defective assembly of the TTSS and protein translocation.

28 face, which was normally active for in vitro protein translocation.

29 the chemomechanical cycle of SecA-dependent protein translocation.

30 Sec71-Sec72 subcomplex in post-translational protein translocation.

31 ogical properties such as cell signaling and protein translocation.

32 t this specific dimer likely promotes active protein translocation.

33 rt, indicating that trapping by Mia40 drives protein translocation.

34 losterically activate SecA for ATP-dependent protein translocation.

35 f course, at the phenylalanine clamp) during protein translocation.

36 uption of clamp opening or closure abolishes protein translocation.

37 tion and hereby acts as a chaperone for PORA protein translocation.

38 play key roles in the molecular mechanism of protein translocation.

39 and supports the Brownian ratchet model for protein translocation.

40 art of the trimeric Ssh1 complex involved in protein translocation.

41 el system for understanding the mechanism of protein translocation.

42 allow substrate binding and movement during protein translocation.

43 ependent conformational changes of SecA with protein translocation.

44 nt to more general features of Gram-positive protein translocation.

45 sting that this enzyme at least partly fuels protein translocation.

46 channel is activated for post-translational protein translocation.

47 te protein O-mannosylation in the context of protein translocation.

48 thereby suggesting a mechanism for effector protein translocation.

49 ethod can be used to quantify drug-dependent protein translocations.

50 Protein translocation across and insertion into membrane

51 Protein translocation across and insertion into membrane

52 unity to explore the molecular mechanisms of protein translocation across biological membranes in pre

53 cell invasion by apicomplexan parasites, and protein translocation across membranes in bacteria.

54 ngs establish a novel type of self-sustained protein translocation across membranes revealing the mol

55 suggest a novel self-sustained mechanism of protein translocation across membranes with a lipidic me

56 of proteins from aggregates, facilitation of protein translocation across membranes, and more special

57 ysis to perform mechanical work resulting in protein translocation across membranes, protein degradat

58 Work on these problems included the study of protein translocation across membranes, the analysis of

59 ecretory mechanism that is based upon direct protein translocation across plasma membranes.

60 Protein translocation across the bacterial cytoplasmic m

61 Post-translational protein translocation across the bacterial plasma membra

62 Toc75 is the channel for protein translocation across the chloroplast outer envel

63 Protein translocation across the cytoplasmic membrane is

64 s ATP and the proton motive force to mediate protein translocation across the cytoplasmic membrane.

65 A critical event in protein translocation across the endoplasmic reticulum i

66 sociated protein (TRAP) complex required for protein translocation across the endoplasmic reticulum m

67 Protein translocation across the ER membrane and N-glyco

68 The first step during protein translocation across the glycosomal membrane of

69 Protein translocation across the mitochondrial inner mem

70 a hydrophobic interactions thereby mediating protein translocation across the outer membrane by a 'ho

71 sequences and receptor proteins, followed by protein translocation across the peroxisomal membrane.

72 x and utilizing its ATPase activity to drive protein translocation across the plasma membrane.

73 proteins appears to remain at least through protein translocation across the pore membrane to the IN

74 reports that have provided new insights into protein translocation across the PV membrane, characteri

75 5 superfamily, whose members are involved in protein translocation across, or integration into, cellu

76 of Clostridium botulinum neurotoxins (BoNTs) protein-translocation across membranes was investigated

77 mutants with FAS-positive insertions retain protein translocation activity.

78 uter membrane, which is postulated to aid in protein translocation after translation.

79 ng of the TRPA1 channels with O(2)-dependent protein translocation allows astrocytes to act as acute

80 hods utilize a sequential "n-step" model for protein translocation along ssDNA and enable quantitativ

81 An understanding of the mechanism of protein translocation along ssDNA requires pre-steady st

82 inetic experiments that can be used to study protein translocation along ssDNA, along with the advant

83 he finding that a folding mutant that allows protein translocation alters an amino acid at the C term

84 ontains a disulfide bond that is crucial for protein translocation and channel gating.

85 This "phi-clamp" structure was required for protein translocation and comprised the major conductanc

86 in can interact with other components of the protein translocation and folding machinery to influence

87 ity and, hence, are essential for organellar protein translocation and folding.

88 tool for fundamental mechanistic enquiry of protein translocation and for inhibitor (drug) screening

89 our current mechanistic understanding of ER protein translocation and general principles of regulato

90 hia coli to promote protein folding, support protein translocation and handle protein misfolding.

91 e major insight into potential mechanisms of protein translocation and injectisome assembly.

92 cular steps affected by the absence of CL in protein translocation and insertion, we analyzed translo

93 These data show that SecA can promote protein translocation and ion channel activities both wh

94 the signal peptide specificity and increases protein translocation and ion channel activities.

95 the signal sequence, is required for proper protein translocation and maturation, while the extended

96 ing how the translocon, which is the site of protein translocation and membrane insertion, decides wh

97 veal key mechanistic features of early-stage protein translocation and membrane integration via the S

98 simulating the minute-timescale dynamics of protein translocation and membrane integration via the S

99 a central component of cellular pathways for protein translocation and membrane integration.

100 eview recent insights into the mechanisms of protein translocation and membrane protein insertion fro

101 tive and exhibited defects in Ssa1-dependent protein translocation and misfolded protein degradation.

102 al role for Magmas and DnaJC19 in organellar protein translocation and mitochondria biogenesis, where

103 ication, thus highlighting its importance in protein translocation and mitochondrial biogenesis.

104 roteins, suggesting unexpected roles for the protein translocation and modification machinery in mRNA

105 , glucosidase IIbeta and SEC63p, function in protein translocation and quality control pathways in th

106 (ClpC1), an AAA-ATPase chaperone involved in protein translocation and quality control.

107 ne the polypeptide path during SecA-mediated protein translocation and suggest a mechanism by which A

108 assess the fate of different transcripts on protein translocation and superoxide production in human

109 as a SP-binding drug to selectively inhibit protein translocation and to reversibly regulate the exp

110 in diminished protein expression, disturbed protein translocation, and an increase in calcium leakag

111 rom mitochondrial membrane change, apoptotic protein translocation, and apoptosis.

112 eased Nrf2 messenger RNA expression, nuclear protein translocation, and DNA binding compared with wil

113 l involved in bacterial envelope biogenesis, protein translocation, and metabolism.

114 TP synthesis, respiration, solute transport, protein translocation, and other physiological processes

115 s represent a family of proteins involved in protein translocation, and they are present in all domai

116 ethal secA mutant, was inactive for in vitro protein translocation, and was poorly active for translo

117 We conclude that N-linked glycosylation and protein translocation are not directly coupled in yeast

118 tic cycle of ATP and how they are coupled to protein translocation are not well understood.

119 By using a Cre/loxP-based protein translocation assay, we found that proteins tran

120 s evaluated using arrestin-green fluorescent protein translocation assays and confocal fluorescence m

121 is technique potentially allows detection of protein translocation at the single-cell level.

122 We show that protein translocation between cytoplasm and nucleus not

123 l models of the cell cycle which incorporate protein translocation between cytoplasm and nucleus.

124 s previously shown to impair Sec61-dependent protein translocation, but the underlying molecular mech

125 dicate a unified hand-over-hand mechanism of protein translocation by Cdc48 and other AAA+ ATPases.

126 SecA facilitates bacterial protein translocation by its association with presecreto

127 ed to C. burnetii effector proteins to study protein translocation by the Dot/Icm system.

128 Here, we examined the proposal that protein translocation can occur by means of a SecA monom

129 The complementation assay for protein translocation (CAPT) is derived from beta-galact

130 le for mediating the interaction between the protein translocation channel and the STT3A complex.

131 Toc75 is known to act as a protein translocation channel at the outer membrane of t

132 The protein translocation channel at the plastid outer envel

133 ether the SRP receptor (SR) locates a vacant protein translocation channel by interacting with the ye

134 prokaryotes involves a universally conserved protein translocation channel formed by the Sec61 comple

135 mplex associates with the ribosome to form a protein translocation channel in the bacterial plasma me

136 Toc75 is postulated to form the protein translocation channel in the chloroplastic outer

137 een the open and closed conformations of the protein translocation channel maintains a balance betwee

138 olic cochaperone that associates with the ER protein translocation channel Sec61.

139 aryltransferase is localized adjacent to the protein translocation channel to catalyze co-translation

140 he STT3A complex interacts directly with the protein translocation channel to mediate cotranslational

141 he STT3A complex interacts directly with the protein translocation channel to mediate glycosylation o

142 The mammalian Sec61 complex forms a protein translocation channel whose function depends upo

143 ribosome-nascent chain complex (RNC) to the protein translocation channel.

144 the evolutionary origin of the chloroplastic protein translocation channel.

145 xes (RNCs) that display a signal sequence to protein translocation channels in target membranes.

146 plexes (RNCs) displaying signal sequences to protein translocation channels in the plasma membrane of

147 arch biosynthesis, fermentation, and plastid protein translocation common to plants and algae but lac

148 In bacteria, the SecYEG protein translocation complex employs the cytosolic ATPa

149 , the ribosome funnel and the channel of the protein translocation complex SecYEG are aligned.

150 c61alpha forms the central subunit of the ER protein translocation complex, and the binding of ipomoe

151 eins, such as SNAREs, apoptosis factors, and protein translocation components.

152 embrane-bound SecA dimer is critical for the protein translocation cycle, although these results cann

153 certain residues in the gating motif cause a protein translocation defect.

154 h severe cold sensitivity and a Sec-specific protein translocation defect.

155 We highlight protein translocation defects across the endoplasmic ret

156 oles for maintaining proper protein folding, protein translocation, degradation of unfolded protein,

157 Moreover, HOCl impaired protein translocation early in the course of bacterial k

158 brane bias values, a substantial fraction of protein translocation events are detected.

159 mark the location of repeated T6SS-mediated protein translocation events between bacterial cells.

160 riggered calcium signaling and intracellular protein translocation events, respectively.

161 oteomic method that allows global mapping of protein translocation events.

162 artment in the secretory pathway involved in protein translocation, folding, glycosylation, quality c

163 hibited BAD (Bcl-2-associated death protein) protein translocation from the cell cytosol to the membr

164 omonas aeruginosa Exotoxin A, which inhibits protein translocation from the ER to the cytosol, abroga

165 In contrast, dynamin-2 facilitates Fas protein translocation from the Golgi apparatus via the t

166 Our data also provide clear evidence for the protein translocation function of Omp85 transporters.

167 nsertion and retraction at SecYEG that drive protein translocation in a stepwise fashion.

168 P-driven conformational changes that promote protein translocation in a stepwise manner.

169 els with only one active pore likely mediate protein translocation in all organisms.

170 machinery constitutes the major pathway for protein translocation in bacteria.

171 luorescent imaging of Arr2-green fluorescent protein translocation in dissociated ommatidia, we show

172 Protein translocation in Escherichia coli is initiated b

173 The SecA nanomotor promotes protein translocation in eubacteria by binding both prot

174 of guanylate cyclase 1 (GC1) on light-driven protein translocation in rod and cone cells.

175 report on the dynamics of transcription and protein translocation in single cells.

176 ptide interaction is critical for initiating protein translocation in the bacterial Sec-dependent pat

177 The role of VIPP1 in protein translocation in the chloroplast has not been in

178 Examples include protein translocation in the endoplasmic reticulum and t

179 is associated with many functions, including protein translocation in the endoplasmic reticulum, vesi

180 a substantial, yet selective, inhibition of protein translocation in vitro and a broad ranging inhib

181 on of calmodulin specifically impaired small-protein translocation in vitro and in cells.

182 ting their interactions to promote efficient protein translocation in vivo.

183 gest that SecA functions as a monomer during protein translocation in vivo.

184 Post-translational protein translocation in yeast requires both the Sec61 t

185 lity to identify inhibitors of mitochondrial protein translocation in yeast validates the generation

186 Furthermore, Yme1 has a new function in protein translocation, indicating that the intermembrane

187 ity of reporter systems to monitor bacterial protein translocation into host cells.

188 rotein EspD, which is essential for effector protein translocation into host cells.

189 Alder et al. examine protein translocation into intact mitochondria by adapti

190 how that SecA alone is sufficient to promote protein translocation into liposomes and to elicit ionic

191 We previously reported that Tat-dependent protein translocation into membrane vesicles of Escheric

192 Tim23 mediates protein translocation into mitochondria.

193 provides new insights about the mechanism of protein translocation into mitochondria.

194 We propose a model to study protein translocation into the chamber of biological unf

195 mechanisms regulating secretory and membrane protein translocation into the endoplasmic reticulum (ER

196 accurately measuring the in vivo fidelity of protein translocation into the endoplasmic reticulum (ER

197 Protein translocation into the endoplasmic reticulum is

198 be cotransin, a small molecule that inhibits protein translocation into the endoplasmic reticulum.

199 ation plays a direct role in cotranslational protein translocation into the ER.

200 gnition by the machinery for cotranslational protein translocation into the ER.

201 tion, Sec61-dependent Ca(2+) homeostasis and protein translocation into the ER.

202 provide strong evidence for PTEX function in protein translocation into the host cell.

203 nner mitochondrial membrane, is critical for protein translocation into the matrix.

204 However, protein translocation involves oligomers of the SecY com

205 Protein translocation is a fundamental process in biolog

206 Thus, protein translocation is a physiologically regulated pro

207 Cotranslational protein translocation is a universally conserved process

208 Protein translocation is also critical for microbial pat

209 ng the molecular mechanisms of mitochondrial protein translocation is crucial for understanding the i

210 basis of this information, the evolution of protein translocation is discussed.

211 Light-driven protein translocation is responsible for the dramatic re

212 however, its oligomeric state during active protein translocation is still unresolved.

213 er-stroke and brownian-ratchet mechanisms of protein translocation is the process through which noneq

214 cytoplasmic membrane is a principal site of protein translocation, lipid and peptidoglycan biogenesi

215 Among the various protein-translocation machineries, the peptidase-contain

216 brane and secretory proteins to the cellular protein translocation machinery during translation.

217 SecDF is an important component of the Sec protein translocation machinery embedded in the bacteria

218 ations in SEC63, encoding a component of the protein translocation machinery in the ER, also cause th

219 tation in a basic component of the cell's ER protein translocation machinery, Sec61alpha1.

220 complex SecYEG form the core of an essential protein translocation machinery.

221 with the SRP receptor, delivers them to the protein-translocation machinery on the target membrane.

222 in vitro lipid binding analyses and cellular protein translocation measurements.

223 mass as plastidial HMR, support a retrograde protein translocation mechanism in which HMR is targeted

224 ous studies have proposed that, unlike other protein translocation mechanisms, Yops are not recognize

225 families of effector proteins containing the protein translocation motif RXLR-dEER.

226 scence (enhanced green fluorescent protein), protein translocation (nuclear localization sequence), D

227 tent, to the inner segments, where polarized protein translocation occurs.

228 transcriptional regulation and intra-nuclear protein translocation of FoxM1 in polyploid cells, respe

229 Kinetic characterizations of protein translocation on DNA are nontrivial because the

230 ion, whereas others appear to be involved in protein translocation or in ribosomal RNA processing and

231 ient transthylakoid proton gradient to drive protein translocation or other processes.

232 an essential component of the Sec-dependent protein translocation pathway across cytoplasmic membran

233 an essential component in the Sec-dependent protein translocation pathway and, together with ATP, pr

234 The Sec-dependent protein translocation pathway promotes the transport of

235 esponse is coupled with the co-translational protein translocation pathway to maintain protein homeos

236 at functions in bacterial post-translational protein translocation pathway.

237 the compatibility and regulation of multiple protein translocation pathways that each makes distinct

238 Protein translocation presumably occurs through a protei

239 igomeric state of functional SecA during the protein translocation process is controversial.

240 g and thinning, which may be central for the protein translocation process.

241 prehensive computer simulations of denatured protein translocation processes through the nanopores sh

242 at induced robust betaarr2-green fluorescent protein translocation produced similar analgesia profile

243 d unbinding rate parameters that balance the protein translocation rate and the efficiency of the sea

244 We propose that regulation of protein translocation represents a potentially general m

245 Because efficient protein translocation requires at least a 100-fold accel

246 wn whether they can be exploited to modulate protein translocation selectively.

247 h178 seems to occur prior to SEC61-dependent protein translocation, since inhibition of MHC-I translo

248 charged residues play a critical role in the protein translocation step that follows TatA assembly.

249 n on the contraction of bacterial phage-like protein-translocation structures directed towards eukary

250 Traditionally, in vitro protein translocation studies have been performed using

251 e increased by ER stress and diminished when protein translocation substrates were depleted.

252 The twin-arginine protein translocation system (Tat) transports folded pro

253 he toxin component of the phage tail-derived protein translocation system Afp, which causes enteric r

254 r components of the Eubacteria Sec-dependent protein translocation system are the heterotrimeric chan

255 The bacterial Sec protein translocation system catalyzes the transport of

256 d to the host cytosol by the Dot/Icm type IV protein translocation system during infection.

257 he dispensability of the cotranslational SRP protein translocation system in a bacterium.

258 ereby S-motility reversals are mediated by a protein translocation system that delivers motility prot

259 Legionella pneumophila requires the Dot/Icm protein translocation system to replicate within host ce

260 lipids that, in the absence of a specialized protein translocation system, appear to constitute the m

261 nt with recent structural insights into this protein translocation system.

262 of this vacuole requires the Dot/Icm type IV protein translocation system.

263 experiments that defined the SecY-dependent protein translocation system.

264 teria, are members of a large superfamily of protein translocation systems that are widely distribute

265 General chaperones are common components of protein translocation systems where they maintain cargo

266 erspectives in studies of phage tail-derived protein translocation systems, which are preserved from

267 be found in, and may be important for, other protein translocation systems.

268 The thylakoid twin arginine protein translocation (Tat) system is thought to have a

269 The twin-arginine protein translocation (Tat) system mediates transport of

270 The thylakoid twin arginine protein translocation (Tat) system operates by a cyclica

271 We develop a reaction-diffusion theory of protein translocation that accounts for transport both o

272 the precise sequence of events that leads to protein translocation, the energetic requirements, or th

273 For post-translational protein translocation, the Sec-channel - SecYEG - associ

274 rmeation through a phospholipid membrane and protein translocation through a channel.

275 re, we report the rectification behaviour of protein translocation through silicon-based truncated py

276 gle-molecule microscopy we could distinguish protein translocation through the central and peripheral

277 roove are shown to have a dramatic effect on protein translocation through the ClpB central pore, sug

278 standing of the ATP power stroke that drives protein translocation through the ClpB hexamer.

279 gical studies to form a clamp that catalyzes protein translocation through the pore.

280 SecA plays a critical role in protein translocation through the SecYEG membrane channe

281 his disulfide bond is critical for efficient protein translocation through the TIM23 complex and for

282 pose a repulsive electrostatic mechanism for protein translocation through the type III secretion app

283 n motive force could be used to energize the protein translocation through these nanomachines.

284 The findings further suggest that protein translocation to the cell envelope is one import

285 -2A is a transmembrane protein component for protein translocation to the lysosome.

286 transmission and at the inner segment during protein translocation to the outer segment.

287 s shown by defects in ATRIP (ATR-interacting protein) translocation to sites of UV damage, UV-induced

288 EGF stimulated HDAC6 enzymatic activity and protein translocation toward the leading edge of the cel

289 trate the utility of this system by inducing protein translocation, transcription and Cre recombinase

290 Protein translocation under a proton motive force is cat

291 scribe a method for quantitatively assessing protein translocation using proximity-induced enzyme com

292 ved in diverse cellular processes, including protein translocation, vesicle trafficking, and apoptosi

293 427 residues of protective antigen catalyses protein translocation via a charge-state-dependent Brown

294 nsistent with its proposed role in enhancing protein translocation via Tat.

295 ity cup to localize secretion substrates for protein translocation via the flagellar-specific type II

296 the regulation of Sec-mediated pathways for protein translocation vs. membrane integration are discu

297 and high light stress; and when Sec-mediated protein translocation was impaired.

298 nsight into the mechanism of autotransporter protein translocation, we performed a structure-function

299 these are the first studies on Tat-dependent protein translocation where both oxidative folding and c

300 assessing rod tet-ARR1 and its reduction via protein translocation, which can be combined with other