ライフサイエンスコーパス: protein transport

1 eract with SecYEG during different stages of protein transport.

2 odel systems for studies of channel-assisted protein transport.

3 irming a general role of N-glycans in apical protein transport.

4 of an ~100 kDa multidomain enzyme and drive protein transport.

5 TatA is unlikely to accompany Tat-dependent protein transport.

6 ion of Rab26 in coordinating plasma membrane protein transport.

7 ignal transduction, metabolism, and membrane protein transport.

8 ons in Escherichia coli TatC that inactivate protein transport.

9 es in accessibility when actively engaged in protein transport.

10 YEG, is responsible for the majority of this protein transport.

11 KMS1/KMS2 truncations inhibited ER to Golgi protein transport.

12 s play key roles in ciliogenesis and ciliary protein transport.

13 igators to probe the molecular mechanisms of protein transport.

14 rk involved in endo-lysosomal maturation and protein transport.

15 dative maturation required for intracellular protein transport.

16 coat subunits to promote efficient secretory protein transport.

17 P, many with established defects in vacuolar protein transport.

18 tional switch that results in activation for protein transport.

19 nuclear envelope regulates directionality of protein transport.

20 of gene transcription, mRNA translation, and protein transport.

21 transcription, cellular ion homeostasis, and protein transport.

22 n, metabolism, iron assimilation, and type I protein transport.

23 ize the transmembrane electric potential for protein transport.

24 vent uncontrolled vesiculation of TGN during protein transport.

25 cycle control, cytoskeleton organization and protein transport.

26 rase to produce a new strategy for measuring protein transport.

27 ys a role in the regulation of intracellular protein transport.

28 pathway in regulating microtubule-dependent protein transport.

29 gamma-secretase activity with intracellular protein transport.

30 overall organization of Golgi membranes and protein transport.

31 p plays an important role in mRNA export and protein transport.

32 he identification of new factors involved in protein transport.

33 of SecA insertion into SecYEG during ongoing protein transport.

34 dent mRNA export in trypanosomes, similar to protein transport.

35 e TIM22 and TIM23 complexes in mitochondrial protein transport.

36 dynamics in interorganelle communication and protein transport.

37 e, we consider the case of a single myosin-V protein transporting a cargo and show that, at realistic

38 Signal peptides (SPs) are critical for protein transport across cellular membranes, have a high

39 This strategy has the potential to improve protein transport across epithelial barriers, which coul

40 polymer conjugates that facilitate selective protein transport across membranes that are typically im

41 secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negat

42 SecA facilitates protein transport across the eubacterial plasma membrane

43 Stringent control of ion and protein transport across the mitochondrial membranes is

44 al peptide and early mature region initiates protein transport across the SecY or Sec61alpha channel

45 The mechanism of SecA-driven protein transport across the SecYEG channel complex has

46 ne, located inside the chloroplast, requires proteins transported across it for plastid biogenesis an

47 d, levels of GTP-bound Arf1 are elevated and protein transport along the secretory pathway is delayed

48 rst report on the mechanisms of HBV envelope protein transport among the organelles, and the results

49 s maturation dependent on intracellular host protein transport and autophagy for the accumulation of

50 osylceramide to CLN3-deficient cells rescues protein transport and caveolar endocytosis.

51 s suggest that Pitx2 acts as an inhibitor of protein transport and cell apoptosis contributing to the

52 elationship may be important for directional protein transport and centrosome positioning, which are

53 lyzes multiple cellular functions, including protein transport and degradation, and to this end, the

54 bout the mechanisms coordinating presynaptic protein transport and deposition to achieve proper distr

55 -domain proteins contribute to both vacuolar protein transport and effector-triggered immunity (ETI).

56 and morphogenesis through control of apical protein transport and endo-lysosomal function.

57 se key proteins included cell proliferation, protein transport and folding, cytoskeletal remodelling

58 sential for a more complete understanding of protein transport and its role in tissue morphogenesis.

59 atopoietic homeostasis through regulation of protein transport and Jam-C expression remains unknown.

60 P155 function causes AF by altering mRNA and protein transport and link the NPC to cardiovascular dis

61 i) ribosomal large subunit biogenesis, (iii) protein transport and localization, and (iv) transcripti

62 hemical properties, to regulate GPI-anchored protein transport and maintain homeostasis in the early

63 complex, which governs endoplasmic reticulum protein transport and passive calcium leakage.

64 EACH-domain proteins contributes to vacuolar protein transport and plant defense.

65 tner, Alix, which is known to be involved in protein transport and regulation of cell surface express

66 haracterized new actors in the mechanisms of protein transport and secretion and opens stimulating pe

67 tin looping and eQTL mapping are enriched in protein transport and secretion pathways.

68 ertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

69 B cells may be highly dependent on ER-Golgi protein transport and that targeting this process may be

70 roteins are generally known as regulators of protein transport and trafficking.

71 3 ligase activities of ARD1 suggest roles in protein transport and turnover.

72 Yeast Vps13 is involved in vacuolar protein transport and, like hVps13A, participates in PI4

73 y ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may

74 s encode a higher-than-expected frequency of proteins transported and utilized in organelles and a pa

75 (S485A) strain has impaired membrane-related protein transport, and its cell size did not become larg

76 has direct impact on cellular bioenergetics, protein transport, and molecular trafficking.

77 ulation, signal transduction, transcription, protein transport, and protein modification tend to be e

78 ncluding use of distinct promoters, mRNA and protein transport, and regulated cleavage of proBDNF to

79 te and lymphocyte activation and chemotaxis, protein transport, and responses to nutrients.

80 e metabolism, down-regulated proteolysis and protein transport, and showed high levels of amino acids

81 s, such as endocytosis, adhesion, signaling, protein transport, apoptosis, and disease pathogenesis.

82 Current models for Tat protein transport are also discussed.

83 f cellular processes including intracellular protein transport as well as constitutive and regulated

84 s of SecA membrane insertion during in vitro protein transport as well as those documenting the membr

85 l functions, being involved in intracellular protein transport, as well as cellular signal transducti

86 In vitro protein transport assays in the presence of a SecY inhib

87 To this end, we conducted in vitro thylakoid protein transport assays to look at the effect of VIPP1

88 stems work-has been limited to discontinuous protein transport assays with poor time resolution or re

89 Using a variety of protein transport assays, we show that the endoplasmic r

90 raction systems were produced for extracting protein transport assertions (transport), protein-protei

91 ein ligands, enabling it to function both in protein transport at endosomes and in cytokinesis and vi

92 Vesicle-mediated protein transport between organelles of the secretory an

93 form a deubiquitylation complex to regulate protein transport between the endoplasmic reticulum and

94 rotein complex responsible for intracellular protein transport between the endoplasmic reticulum and

95 ch is a clathrin adapter protein involved in protein transport between the Golgi and the vacuole, cau

96 In budding yeast, protein transport between the trans-Golgi network (TGN)

97 le of Rab8 GTPase, which modulates vesicular protein transport between the trans-Golgi network (TGN)

98 ga adaptors participate in clathrin-mediated protein transport between the trans-Golgi network and en

99 s and genes involved in adaptive metabolism, protein transport, biosynthesis pathways, stress resista

100 nd are presumed to have an analogous role in protein transport, but they may be specifically adapted

101 or protein plays a central role in bacterial protein transport by binding substrate proteins and the

102 This finding suggests that TatA facilitates protein transport by sensitizing the membrane to transie

103 anding, we find that current observations on protein transport cannot rule out cisternal progression

104 ion and strongly support the notion that Amt proteins transport cations (NH4(+) or, in mutant protein

105 mycobacterial membrane protein large (MmpL) proteins transport cell envelope lipids and siderophores

106 Dynein and kinesin motor proteins transport cellular cargoes toward opposite ends

107 The SecYEG translocon constitutes the major protein transport channel in bacteria and transfers an e

108 The Sec translocon constitutes a ubiquitous protein transport channel that consists in bacteria of t

109 CLC proteins transport chloride (Cl(-)) ions across cell mem

110 CLC proteins transport chloride (Cl(-)) ions across cellular

111 Like prokaryotic Sec-dependent protein transport, chloroplasts utilize SecA.

112 ession assays show that this plasma membrane protein transports cholinergic compounds with the highes

113 NH(3)/NH(4)(+), whereas others think that Rh proteins transport CO(2) and Amt proteins NH(3).

114 ar pore complexes (NPCs) correspond to large protein transport complexes responsible for selective nu

115 teraction surfaces of pre-assembled scaffold protein transport complexes, thus, favouring physiologic

116 e production of other acinetobactin membrane protein transport components, such as BauB and BauE, or

117 n, cross-linked precursors were subjected to protein transport conditions.

118 inhibitor of endoplasmic reticulum-to-Golgi protein transport, consistent with an effect on traffick

119 nt inhibited both anterograde and retrograde protein transport, consistent with the loss of membrane

120 or complex that regulates ciliary retrograde protein transport contains a heavy chain dynein ATPase/m

121 Cu-ATPase ATP7B (Wilson's disease protein) transports copper into the trans-Golgi network

122 bitor of endoplasmic reticulum (ER) to Golgi protein transport currently being developed as a novel a

123 complex to span the membrane to promote the protein transport cycle.

124 nt often with retinal degeneration caused by protein transport defects between the inner segment and

125 Our results demonstrate that apical protein transport depends on selective microtubule motor

126 In addition to protein transport, DnaJC15 also showed a dual role in ye

127 cleotidase, ecto (NT5E), transmembrane emp24 protein transport domain containing 6 (TMED6), and p21 p

128 yoimmunoelectron microscopy (CEM) to examine protein transport during HIV-1 assembly in productively

129 Each CDF protein transports either one specific metal or multiple

130 gress has been made toward understanding how protein transport, endocytosis, and intercellular intera

131 Both proteins transport folates when expressed in Escherichia

132 simultaneously track thrombus formation and protein transport following injuries to mouse cremaster

133 tion and conversion, membrane integrity, and protein transport following produced water exposure, whi

134 ly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi netw

135 sing the kinase activity of PKCeta-inhibited protein transport from TGN to the cell surface.

136 Protein transport from the endoplasmic reticulum to and

137 blocks the formation of vesicles involved in protein transport from the endoplasmic reticulum to the

138 de-sensitive factor and reduces the speed of protein transport from the endoplasmic reticulum to the

139 f Rab4, a Ras-like small GTPase coordinating protein transport from the endosome to the plasma membra

140 er that allows real-time imaging of membrane protein transport from the ER to the INM using Lamin B r

141 cerevisiae, is required for vesicle-mediated protein transport from the Golgi and endosomes, suggesti

142 pindle formation in mitosis, is required for protein transport from the Golgi complex to the cell sur

143 tionship between these two key regulators of protein transport from the TGN so far is elusive.

144 for Golgi-localized Gbetagamma in regulating protein transport from the TGN to the cell surface.

145 ng proteins Ent3p and Ent5p are required for protein transport from the trans-Golgi network (TGN) to

146 The protein transports from the cell cytosol to the mitochon

147 equilibrative nucleoside transporter (hENT1) protein transports gemcitabine into cells.

148 Magmas/Pam16, is required for mitochondrial protein transport, growth, and survival.

149 brucei genome, but its function in lipidated protein transport has not been characterized.

150 A role for Toc64 in protein transport has not been established, however.

151 the host cell, including a potential role in protein transport, however the further molecular players

152 has been proposed to have a role in ciliary protein transport; however, its function remains elusive

153 Tubby-related proteins regulate ciliary protein transport; however, their roles in remodeling ci

154 the steps that constitute posttranslational protein transport in bacteria.

155 TP, an action critical for the regulation of protein transport in eukaryotic cells.

156 ic roles of biomedical predicates describing protein transport in GeneRIFs - manually curated sentenc

157 pathies will illuminate the role of membrane protein transport in human disease.

158 e importance of protein surface diffusion in protein transport in ion-exchange chromatography.

159 a support a diffusion retention model of INM protein transport in mammalian cells.

160 t from currently studied pathways of ciliary protein transport in mammals, which emphasize directed t

161 Impaired ciliary protein transport in olfactory sensory neurons (OSNs) le

162 outes are essential for our understanding of protein transport in primary cilia, a critically affecte

163 unit complex that plays an important role in protein transport in primary cilia.

164 osis, total protein synthesis, and secretory protein transport in response to a secretory stimulus.

165 gulates membrane morphogenesis and signaling protein transport in specialized sensory cilia.

166 ific phospholipid substrate requirements for protein transport in this pathway are unknown.

167 e ATPases essential for pilus biogenesis and protein transport in type IV secretion systems.

168 priate targeting factors, are sufficient for protein transport in vitro However, in vivo the SecYEG t

169 gene regulation, protein export and ion and protein transport, indicating that cGMP/PfPKG acts as a

170 This system for extracting protein transport information from GeneRIFs performs wel

171 The protein transport inhibitor brefeldin-A prevented INa in

172 rotein synthesis inhibitor cycloheximide nor protein transport inhibitor monensin, indicating that HD

173 ring complex) and HOPS (homotypic fusion and protein transport) interact with endolysosomal Rabs to c

174 Protein transport into or across the membrane is then fa

175 A unique aspect of protein transport into plastids is the coordinate involv

176 In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is

177 For a long time, protein transport into the extracellular space was belie

178 ospholipids like phosphatidylcholine (PC) in protein transport into the inner membrane and the matrix

179 Protein transport into the nucleus is mediated by transp

180 epair pathway disrupt binding of the encoded proteins, transport into the nucleus and initiation of h

181 structure, there is evidence that, for some proteins, transport is a regulated process.

182 via a variety of mechanisms, including motor protein transport, local binding, and diffusion barriers

183 he morphological structure of F-actin and in protein transport, loss of this function might be the tr

184 The HTL is a dynamic and flexible protein transport machine capable of coordinating protei

185 Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movem

186 VII secretion systems (T7SSs) are dedicated protein transport machineries that fulfill diverse and c

187 hlights the enormous plasticity of bacterial protein transport machineries.

188 s are evidence that tumor cells modulate the protein transport machinery thereby making the protein t

189 the notion that tumor cells can modulate the protein transport machinery thereby making the protein t

190 1 integrase can employ the classical nuclear protein transport machinery to enter the nucleus.

191 nelles, with their unique and highly adapted protein transport machinery, have been studied extensive

192 ction of multiple signaling pathways and the protein transport machinery.

193 trategy to highjack the peroxisomal membrane proteins' transport machinery.

194 ytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means o

195 ll be critical for elucidating the bacterial protein transport mechanism.

196 d 14-3-3 participated in cytosolic precursor protein transport mediated by the coordinated activities

197 ubule functions (sodium and water transport, protein transport, metabolic functions, endocrine functi

198 ble reaction period; and 3) longer precursor proteins transported more slowly than shorter precursor

199 ocalization occurs through three mechanisms: protein transport, mRNA localization, and local translat

200 ans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of riboso

201 , Golgi-localized complex glycosylation, and protein transport, occur independently of oxygen availab

202 Protein transport occurs when Tha4 joins the receptor co

203 Plasma protein transport of copper from the intestine to liver

204 This translates to a DeltaG(protein) (transport) of some 27,300 kJ/mol protein impor

205 of Btn2p, involved in late endosome to Golgi protein transport, or its paralog Cur1p, cures [URE3].

206 that changes in the kinetics of expression, protein transport, or protein binding dramatically alter

207 n of genes encoding functions in ER-to-Golgi protein transport, oxidative protein folding, and ER-ass

208 sterol biosynthesis, fatty acid metabolism, protein transport, oxidoreductase activity, and peroxiso

209 d insights into the mechanism by which these proteins transport P(i), whereas in vivo and ex vivo cel

210 n a folded conformation by the twin arginine protein transport pathway (Tat) transport pathway.

211 sport (IFT) is assumed to be the predominant protein transport pathway in cilia, but it remains large

212 r engineering, including manipulation of the protein transport pathway, codon optimization, and co-ex

213 h compounds known to the block the classical protein transport pathway, including monensin, brefeldin

214 However, precise protein transport pathways requiring Drs2p and how it co

215 Protein transport plays a critical role in the interacti

216 Many of these proteins transport primarily H(+) or K(+) but also trans

217 otein transport machinery thereby making the protein transport process a viable therapeutic target.

218 otein transport machinery thereby making the protein transport process a viable therapeutic target.

219 of macrophages profoundly count on vesicular protein transport processes, down-regulation of 7SL RNA

220 gnal recognition particle-mediated vesicular protein transport processes, we have tested and found th

221 cking, coincident with reduced levels of the protein transport protein Sec31A in CRT-deficient cells.

222 chemical proteomics to identify Sec61alpha (protein transport protein Sec61 subunit alpha isoform 1)

223 rotein called PCSK9 and Sec24A, a well known protein-transport protein, could lead to the development

224 egories; signal transduction, transcription, protein transport, protein synthesis, smooth muscle cont

225 w that regional differences in intrathrombus protein transport rates emerge early in the hemostatic r

226 involve similar structural mechanics to the protein transport reaction.

227 To date, the mechanism it utilizes for protein transport remains unclear.

228 During inflammation, serum amyloid A proteins transport retinol to infected tissues.

229 d transcription factors, and neurite growth, protein transport, RNA processing, cholesterol biosynthe

230 ing at the beginning, inside or outside of a protein transport role.

231 c parsing, and because the boundaries of our protein transport roles often did not match up with synt

232 ule-based methods previously used to extract protein transport roles.

233 t the stereociliary bundle but not along the protein transport route in the cell body.

234 During protein transport, SecYEG is likely to interact also wit

235 Our models were able to label protein transport semantic roles with 87.6% precision an

236 of Rab1, a Ras-like GTPase that coordinates protein transport specifically from the ER to the Golgi,

237 chniques showed that transition to an active protein transport state resulted in an alignment of the

238 s) are required in multiple vesicle-mediated protein transport steps and are proposed to be phospholi

239 While DASS proteins transport substrates via an elevator mechanism,

240 raflagellar transport (IFT), the predominant protein transport system in flagella.

241 ies of the Tat (twin arginine translocation) protein transport system.

242 Influenza A virus uses cellular protein transport systems (e.g., CRM1-mediated nuclear e

243 location (Tat) pathway is one of two general protein transport systems found in the prokaryotic cytop

244 emarkably, impairments in cytoskeleton-based protein-transport systems often underlie cognitive defic

245 h and facilitate import of the bacterial DNA-protein transport (T) complexes into the plant cell nucl

246 The twin-arginine protein transport (Tat pathway) is found in prokaryotes

247 secrete many proteins via the twin arginine protein transport (Tat) pathway, including several prote

248 umbers of lipoproteins via the twin arginine protein transport (Tat) pathway.

249 The twin arginine protein transport (Tat) system translocates folded prote

250 These data suggest that the wild-type protein transports the inhibitory protein to the pathway

251 Many think Rh and Amt proteins transport the same substrate, NH(3)/NH(4)(+), w

252 While engaged in protein transport, the bacterial translocon SecYEG must

253 ecause protein synthesis is much slower than protein transport, the use of YidC as an additional inte

254 is, and suggest that distinct virus movement proteins transport their cargos to plasmodesmata for cel

255 otic target cells by a process that involves protein transport through a contractile bacteriophage ta

256 In particular, protein transport through a fibrin network, an important

257 results represent the first demonstration of protein transport through a nucleoside salvage pathway.

258 nnecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesic

259 m length of 20 mum, is an extreme example of protein transport through channels.

260 We found that VIPP1 does indeed enhance protein transport through the cpTat pathway by up to 100

261 our understanding of the molecular basis for protein transport through the Golgi and within the endoc

262 ordihydroguaiartic acid (NDGA), which blocks protein transport through the Golgi, were investigated.

263 istor, whereby gate voltage mediates DNA and protein transport through the nanopore.

264 e directionality of the Brownian ratchet for protein transport through the Sec machinery.

265 ng events and template the directionality of protein transport through the secretory and endocytic pa

266 ition of another major anabolic pathway, the protein transport through the secretory pathway, and to

267 of cisternal maturation matches the rate of protein transport through the secretory pathway, suggest

268 If protein transport through the SecYEG pore is the rate-li

269 tabolism, (ii) sporozoite biology, and (iii) protein transport to and from the host erythrocyte.

270 e second messenger Ca(2+), allowing membrane protein transport to be adjusted according to physiologi

271 counting of the cost in Gibbs free energy of protein transport to be undertaken.

272 matodendritic compartment, where it controls protein transport to establish and maintain neuron polar

273 mutants gfs3 and gfs12 with a defect in seed protein transport to PSV.

274 the GPI anchor or when we inhibited general protein transport to the cell surface, indicating that a

275 nction for the polarity protein Par6alpha in protein transport to the centrosome.

276 l signal sequence region of cdE2 affected E2 protein transport to the plasma membrane, while nonbuddi

277 ible roles for degradation and alteration of protein transport to the plasma membrane.

278 uggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane.

279 t, but not a PM-targeted GRK2ct, also blocks protein transport to the PM.

280 of the need for electric fields in achieving protein transport to the substrate and confirmed experim

281 tin causes complex dissociation and triggers protein transport to the target organelle.

282 ythrocyte surface antigen (RESA), a parasite protein transported to the host spectrin network, on def

283 e used this approach to identify and compare proteins transported to synapses by kinesin (Kif) comple

284 otor kinesins to identify the populations of proteins transported to synapses.

285 lization of biosynthetic and endocytic cargo proteins transported to the multivesicular body (MVB).

286 This category of protein transport, together with the similar process tha

287 containing a deletion mutant of the C03H5.2 protein transport UDP-N-acetylglucosamine at rates compa

288 Similar to protein transport vesicles (PTVs), VTVs require coat com

289 Time-lapse imaging of synaptic vesicle protein transport vesicles (STVs) indicates that STVs pa

290 Nrxns comigrate as cargo on synaptic vesicle protein transport vesicles (STVs).

291 Kes1p also represses formation of protein transport vesicles from the trans-Golgi network

292 n for its fast shuffling of synaptic vesicle protein transport vesicles in axons.

293 bstrates must be discriminated from those of proteins transported via other pathways.

294 In this study, the role of DBC2 in protein transport was analyzed using vesicular stomatiti

295 he mechanism and energetics of bacterial Tat protein transport, we developed an efficient in vitro tr

296 ndoplasmic reticulum-to-Golgi and post-Golgi protein transports were impaired in betaIII spectrin-dep

297 ithin a pre-protein is an unexplored area of protein transport, which may apply to other protein tran

298 rip coated with POEGMA facilitates effective protein transport while also confining the colorimetric

299 a novel mechanism of SRP-dependent membrane protein transport with the cpSRP54/uL4 interaction as a

300 ve developed a mathematical model of nuclear protein transport within a myotube that recapitulates th