ライフサイエンスコーパス: protein transport

1 TatA is unlikely to accompany Tat-dependent protein transport.

2 ion of Rab26 in coordinating plasma membrane protein transport.

3 ignal transduction, metabolism, and membrane protein transport.

4 ons in Escherichia coli TatC that inactivate protein transport.

5 es in accessibility when actively engaged in protein transport.

6 YEG, is responsible for the majority of this protein transport.

7 KMS1/KMS2 truncations inhibited ER to Golgi protein transport.

8 s play key roles in ciliogenesis and ciliary protein transport.

9 igators to probe the molecular mechanisms of protein transport.

10 rk involved in endo-lysosomal maturation and protein transport.

11 dative maturation required for intracellular protein transport.

12 coat subunits to promote efficient secretory protein transport.

13 P, many with established defects in vacuolar protein transport.

14 tional switch that results in activation for protein transport.

15 nuclear envelope regulates directionality of protein transport.

16 transcription, cellular ion homeostasis, and protein transport.

17 of SecA insertion into SecYEG during ongoing protein transport.

18 n, metabolism, iron assimilation, and type I protein transport.

19 ize the transmembrane electric potential for protein transport.

20 vent uncontrolled vesiculation of TGN during protein transport.

21 cycle control, cytoskeleton organization and protein transport.

22 ys a role in the regulation of intracellular protein transport.

23 pathway in regulating microtubule-dependent protein transport.

24 gamma-secretase activity with intracellular protein transport.

25 overall organization of Golgi membranes and protein transport.

26 p plays an important role in mRNA export and protein transport.

27 ubstrate in vivo for the role Drs2p plays in protein transport.

28 art, through the modulation of intracellular protein transport.

29 sses such as transcription, translation, and protein transport.

30 useful model system for studying chloroplast protein transport.

31 upon the transmembrane pH gradient to drive protein transport.

32 dent mRNA export in trypanosomes, similar to protein transport.

33 e TIM22 and TIM23 complexes in mitochondrial protein transport.

34 dynamics in interorganelle communication and protein transport.

35 eract with SecYEG during different stages of protein transport.

36 odel systems for studies of channel-assisted protein transport.

37 irming a general role of N-glycans in apical protein transport.

38 of an ~100 kDa multidomain enzyme and drive protein transport.

39 e, we consider the case of a single myosin-V protein transporting a cargo and show that, at realistic

40 Signal peptides (SPs) are critical for protein transport across cellular membranes, have a high

41 This strategy has the potential to improve protein transport across epithelial barriers, which coul

42 polymer conjugates that facilitate selective protein transport across membranes that are typically im

43 secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negat

44 SecA facilitates protein transport across the eubacterial plasma membrane

45 Stringent control of ion and protein transport across the mitochondrial membranes is

46 al peptide and early mature region initiates protein transport across the SecY or Sec61alpha channel

47 The mechanism of SecA-driven protein transport across the SecYEG channel complex has

48 ne, located inside the chloroplast, requires proteins transported across it for plastid biogenesis an

49 We therefore observe that protein transport along DNA by direct transfers occurs e

50 d, levels of GTP-bound Arf1 are elevated and protein transport along the secretory pathway is delayed

51 osylceramide to CLN3-deficient cells rescues protein transport and caveolar endocytosis.

52 s suggest that Pitx2 acts as an inhibitor of protein transport and cell apoptosis contributing to the

53 elationship may be important for directional protein transport and centrosome positioning, which are

54 lyzes multiple cellular functions, including protein transport and degradation, and to this end, the

55 torsinA, which is thought to play a role in protein transport and degradation.

56 bout the mechanisms coordinating presynaptic protein transport and deposition to achieve proper distr

57 -domain proteins contribute to both vacuolar protein transport and effector-triggered immunity (ETI).

58 and morphogenesis through control of apical protein transport and endo-lysosomal function.

59 se key proteins included cell proliferation, protein transport and folding, cytoskeletal remodelling

60 sential for a more complete understanding of protein transport and its role in tissue morphogenesis.

61 P155 function causes AF by altering mRNA and protein transport and link the NPC to cardiovascular dis

62 i) ribosomal large subunit biogenesis, (iii) protein transport and localization, and (iv) transcripti

63 EACH-domain proteins contributes to vacuolar protein transport and plant defense.

64 tner, Alix, which is known to be involved in protein transport and regulation of cell surface express

65 ertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

66 B cells may be highly dependent on ER-Golgi protein transport and that targeting this process may be

67 roteins are generally known as regulators of protein transport and trafficking.

68 the host plasma membrane and is involved in protein transport and trafficking.

69 3 ligase activities of ARD1 suggest roles in protein transport and turnover.

70 Yeast Vps13 is involved in vacuolar protein transport and, like hVps13A, participates in PI4

71 animal proteins that regulate intracellular protein transport and/or mitogen-activated protein kinas

72 y ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may

73 s encode a higher-than-expected frequency of proteins transported and utilized in organelles and a pa

74 has direct impact on cellular bioenergetics, protein transport, and molecular trafficking.

75 pressed, whereas genes in ionic homeostasis, protein transport, and plant hormonal regulation were re

76 ulation, signal transduction, transcription, protein transport, and protein modification tend to be e

77 ncluding use of distinct promoters, mRNA and protein transport, and regulated cleavage of proBDNF to

78 te and lymphocyte activation and chemotaxis, protein transport, and responses to nutrients.

79 e metabolism, down-regulated proteolysis and protein transport, and showed high levels of amino acids

80 : the glycan at position 68 is essential for protein transport, and those at positions 36 and 75 modu

81 s, such as endocytosis, adhesion, signaling, protein transport, apoptosis, and disease pathogenesis.

82 Current models for Tat protein transport are also discussed.

83 f cellular processes including intracellular protein transport as well as constitutive and regulated

84 s of SecA membrane insertion during in vitro protein transport as well as those documenting the membr

85 l functions, being involved in intracellular protein transport, as well as cellular signal transducti

86 To this end, we conducted in vitro thylakoid protein transport assays to look at the effect of VIPP1

87 Using a variety of protein transport assays, we show that the endoplasmic r

88 raction systems were produced for extracting protein transport assertions (transport), protein-protei

89 ein ligands, enabling it to function both in protein transport at endosomes and in cytokinesis and vi

90 Pma1-7 ubiquitination in mutants blocked in protein transport at various steps of the secretory path

91 on the location of KDEL-R, we tested whether protein transport between ER and the Golgi apparatus inv

92 Vesicle-mediated protein transport between organelles of the secretory an

93 form a deubiquitylation complex to regulate protein transport between the endoplasmic reticulum and

94 rotein complex responsible for intracellular protein transport between the endoplasmic reticulum and

95 ch is a clathrin adapter protein involved in protein transport between the Golgi and the vacuole, cau

96 Protein transport between the nucleus and cytoplasm requ

97 le of Rab8 GTPase, which modulates vesicular protein transport between the trans-Golgi network (TGN)

98 In budding yeast, protein transport between the trans-Golgi network (TGN)

99 ga adaptors participate in clathrin-mediated protein transport between the trans-Golgi network and en

100 s and genes involved in adaptive metabolism, protein transport, biosynthesis pathways, stress resista

101 The combined results suggest that the SloABC proteins transport both metals, although the SloR protei

102 nd are presumed to have an analogous role in protein transport, but they may be specifically adapted

103 or protein plays a central role in bacterial protein transport by binding substrate proteins and the

104 This finding suggests that TatA facilitates protein transport by sensitizing the membrane to transie

105 ExoU, a protein transported by the type III secretion system of

106 anding, we find that current observations on protein transport cannot rule out cisternal progression

107 mbly and structural evolution of COPII (coat protein) transport carriers that are essential for the t

108 ion and strongly support the notion that Amt proteins transport cations (NH4(+) or, in mutant protein

109 Dynein and kinesin motor proteins transport cellular cargoes toward opposite ends

110 The Sec translocon constitutes a ubiquitous protein transport channel that consists in bacteria of t

111 CLC proteins transport chloride (Cl(-)) ions across cell mem

112 CLC proteins transport chloride (Cl(-)) ions across cellular

113 Like prokaryotic Sec-dependent protein transport, chloroplasts utilize SecA.

114 ession assays show that this plasma membrane protein transports cholinergic compounds with the highes

115 NH(3)/NH(4)(+), whereas others think that Rh proteins transport CO(2) and Amt proteins NH(3).

116 ar pore complexes (NPCs) correspond to large protein transport complexes responsible for selective nu

117 teraction surfaces of pre-assembled scaffold protein transport complexes, thus, favouring physiologic

118 e production of other acinetobactin membrane protein transport components, such as BauB and BauE, or

119 n, cross-linked precursors were subjected to protein transport conditions.

120 inhibitor of endoplasmic reticulum-to-Golgi protein transport, consistent with an effect on traffick

121 or complex that regulates ciliary retrograde protein transport contains a heavy chain dynein ATPase/m

122 Cu-ATPase ATP7B (Wilson's disease protein) transports copper into the trans-Golgi network

123 understanding of the molecular mechanisms of protein transport, crystal nucleation, growth, and defec

124 bitor of endoplasmic reticulum (ER) to Golgi protein transport currently being developed as a novel a

125 complex to span the membrane to promote the protein transport cycle.

126 nt often with retinal degeneration caused by protein transport defects between the inner segment and

127 Our results demonstrate that apical protein transport depends on selective microtubule motor

128 In addition to protein transport, DnaJC15 also showed a dual role in ye

129 cleotidase, ecto (NT5E), transmembrane emp24 protein transport domain containing 6 (TMED6), and p21 p

130 yoimmunoelectron microscopy (CEM) to examine protein transport during HIV-1 assembly in productively

131 causes cargo-specific defects in anterograde protein transport early in the secretory pathway and per

132 gress has been made toward understanding how protein transport, endocytosis, and intercellular intera

133 Both proteins transport folates when expressed in Escherichia

134 simultaneously track thrombus formation and protein transport following injuries to mouse cremaster

135 tion and conversion, membrane integrity, and protein transport following produced water exposure, whi

136 ly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi netw

137 Protein transport from ER to the Golgi apparatus however

138 sing the kinase activity of PKCeta-inhibited protein transport from TGN to the cell surface.

139 Protein transport from the endoplasmic reticulum to and

140 blocks the formation of vesicles involved in protein transport from the endoplasmic reticulum to the

141 de-sensitive factor and reduces the speed of protein transport from the endoplasmic reticulum to the

142 f Rab4, a Ras-like small GTPase coordinating protein transport from the endosome to the plasma membra

143 consistent with Rab1 function in regulating protein transport from the ER to the Golgi.

144 er that allows real-time imaging of membrane protein transport from the ER to the INM using Lamin B r

145 cerevisiae, is required for vesicle-mediated protein transport from the Golgi and endosomes, suggesti

146 s, which may be linked to its involvement in protein transport from the Golgi apparatus to the endopl

147 pindle formation in mitosis, is required for protein transport from the Golgi complex to the cell sur

148 tionship between these two key regulators of protein transport from the TGN so far is elusive.

149 for Golgi-localized Gbetagamma in regulating protein transport from the TGN to the cell surface.

150 uld be required for the function of Drs2p in protein transport from the TGN.

151 ng proteins Ent3p and Ent5p are required for protein transport from the trans-Golgi network (TGN) to

152 The protein transports from the cell cytosol to the mitochon

153 equilibrative nucleoside transporter (hENT1) protein transports gemcitabine into cells.

154 Magmas/Pam16, is required for mitochondrial protein transport, growth, and survival.

155 A role for Toc64 in protein transport has not been established, however.

156 the host cell, including a potential role in protein transport, however the further molecular players

157 has been proposed to have a role in ciliary protein transport; however, its function remains elusive

158 TP, an action critical for the regulation of protein transport in eukaryotic cells.

159 ic roles of biomedical predicates describing protein transport in GeneRIFs - manually curated sentenc

160 pathies will illuminate the role of membrane protein transport in human disease.

161 a support a diffusion retention model of INM protein transport in mammalian cells.

162 t from currently studied pathways of ciliary protein transport in mammals, which emphasize directed t

163 Impaired ciliary protein transport in olfactory sensory neurons (OSNs) le

164 ane potential on the rate and selectivity of protein transport in PEG-thiol-treated gold nanotube mem

165 outes are essential for our understanding of protein transport in primary cilia, a critically affecte

166 osis, total protein synthesis, and secretory protein transport in response to a secretory stimulus.

167 ore size affects the rate and selectivity of protein transport in synthetic membranes.

168 ated small GTPase that coordinates vesicular protein transport in the early secretory pathway, in the

169 ific phospholipid substrate requirements for protein transport in this pathway are unknown.

170 e ATPases essential for pilus biogenesis and protein transport in type IV secretion systems.

171 trongly suggest that efficient neurofilament protein transport in vivo minimally requires hetero-olig

172 gene regulation, protein export and ion and protein transport, indicating that cGMP/PfPKG acts as a

173 This system for extracting protein transport information from GeneRIFs performs wel

174 The protein transport inhibitor brefeldin-A prevented INa in

175 rotein synthesis inhibitor cycloheximide nor protein transport inhibitor monensin, indicating that HD

176 ring complex) and HOPS (homotypic fusion and protein transport) interact with endolysosomal Rabs to c

177 Protein transport into or across the membrane is then fa

178 A unique aspect of protein transport into plastids is the coordinate involv

179 In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is

180 In vps1 cells in which protein transport into the endosomal pathway is blocked,

181 For a long time, protein transport into the extracellular space was belie

182 ospholipids like phosphatidylcholine (PC) in protein transport into the inner membrane and the matrix

183 epair pathway disrupt binding of the encoded proteins, transport into the nucleus and initiation of h

184 structure, there is evidence that, for some proteins, transport is a regulated process.

185 c complex that facilitates posttranslational protein transport, is inactive as the GEF for SRbeta

186 via a variety of mechanisms, including motor protein transport, local binding, and diffusion barriers

187 he morphological structure of F-actin and in protein transport, loss of this function might be the tr

188 Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movem

189 s are evidence that tumor cells modulate the protein transport machinery thereby making the protein t

190 the notion that tumor cells can modulate the protein transport machinery thereby making the protein t

191 1 integrase can employ the classical nuclear protein transport machinery to enter the nucleus.

192 nents of the thylakoid deltapH-dependent/Tat protein transport machinery was analyzed in vitro.

193 nelles, with their unique and highly adapted protein transport machinery, have been studied extensive

194 ction of multiple signaling pathways and the protein transport machinery.

195 trategy to highjack the peroxisomal membrane proteins' transport machinery.

196 ytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means o

197 ll be critical for elucidating the bacterial protein transport mechanism.

198 ble reaction period; and 3) longer precursor proteins transported more slowly than shorter precursor

199 ocalization occurs through three mechanisms: protein transport, mRNA localization, and local translat

200 ans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of riboso

201 , Golgi-localized complex glycosylation, and protein transport, occur independently of oxygen availab

202 Protein transport occurs when Tha4 joins the receptor co

203 Plasma protein transport of copper from the intestine to liver

204 This translates to a DeltaG(protein) (transport) of some 27,300 kJ/mol protein impor

205 of Btn2p, involved in late endosome to Golgi protein transport, or its paralog Cur1p, cures [URE3].

206 n of genes encoding functions in ER-to-Golgi protein transport, oxidative protein folding, and ER-ass

207 sterol biosynthesis, fatty acid metabolism, protein transport, oxidoreductase activity, and peroxiso

208 n a folded conformation by the twin arginine protein transport pathway (Tat) transport pathway.

209 sport (IFT) is assumed to be the predominant protein transport pathway in cilia, but it remains large

210 r engineering, including manipulation of the protein transport pathway, codon optimization, and co-ex

211 h compounds known to the block the classical protein transport pathway, including monensin, brefeldin

212 However, precise protein transport pathways requiring Drs2p and how it co

213 Protein transport plays a critical role in the interacti

214 Many of these proteins transport primarily H(+) or K(+) but also trans

215 , possibly through rescuing transcription or protein transport problems.

216 otein transport machinery thereby making the protein transport process a viable therapeutic target.

217 otein transport machinery thereby making the protein transport process a viable therapeutic target.

218 of macrophages profoundly count on vesicular protein transport processes, down-regulation of 7SL RNA

219 gnal recognition particle-mediated vesicular protein transport processes, we have tested and found th

220 rotein called PCSK9 and Sec24A, a well known protein-transport protein, could lead to the development

221 olved in cell cycle, cytoskeleton, adhesion, protein transport, protein modification, transcription,

222 egories; signal transduction, transcription, protein transport, protein synthesis, smooth muscle cont

223 w that regional differences in intrathrombus protein transport rates emerge early in the hemostatic r

224 involve similar structural mechanics to the protein transport reaction.

225 To date, the mechanism it utilizes for protein transport remains unclear.

226 During inflammation, serum amyloid A proteins transport retinol to infected tissues.

227 d transcription factors, and neurite growth, protein transport, RNA processing, cholesterol biosynthe

228 ing at the beginning, inside or outside of a protein transport role.

229 c parsing, and because the boundaries of our protein transport roles often did not match up with synt

230 ule-based methods previously used to extract protein transport roles.

231 t the stereociliary bundle but not along the protein transport route in the cell body.

232 During protein transport, SecYEG is likely to interact also wit

233 Our models were able to label protein transport semantic roles with 87.6% precision an

234 Rab1 GTPase coordinates vesicle-mediated protein transport specifically from the endoplasmic reti

235 of Rab1, a Ras-like GTPase that coordinates protein transport specifically from the ER to the Golgi,

236 chniques showed that transition to an active protein transport state resulted in an alignment of the

237 s) are required in multiple vesicle-mediated protein transport steps and are proposed to be phospholi

238 We have previously implicated Drs2p in protein transport steps in the late secretory pathway re

239 raflagellar transport (IFT), the predominant protein transport system in flagella.

240 ies of the Tat (twin arginine translocation) protein transport system.

241 Influenza A virus uses cellular protein transport systems (e.g., CRM1-mediated nuclear e

242 location (Tat) pathway is one of two general protein transport systems found in the prokaryotic cytop

243 h and facilitate import of the bacterial DNA-protein transport (T) complexes into the plant cell nucl

244 secrete many proteins via the twin arginine protein transport (Tat) pathway, including several prote

245 umbers of lipoproteins via the twin arginine protein transport (Tat) pathway.

246 The Escherichia coli twin-arginine protein transport (Tat) system is a molecular machine de

247 The twin arginine protein transport (Tat) system translocates folded prote

248 These data suggest that the wild-type protein transports the inhibitory protein to the pathway

249 Many think Rh and Amt proteins transport the same substrate, NH(3)/NH(4)(+), w

250 While engaged in protein transport, the bacterial translocon SecYEG must

251 ecause protein synthesis is much slower than protein transport, the use of YidC as an additional inte

252 is, and suggest that distinct virus movement proteins transport their cargos to plasmodesmata for cel

253 These mini-stacks are able to carry out protein transport, though with reduced efficiency compar

254 otic target cells by a process that involves protein transport through a contractile bacteriophage ta

255 In particular, protein transport through a fibrin network, an important

256 results represent the first demonstration of protein transport through a nucleoside salvage pathway.

257 nnecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesic

258 m length of 20 mum, is an extreme example of protein transport through channels.

259 We found that VIPP1 does indeed enhance protein transport through the cpTat pathway by up to 100

260 our understanding of the molecular basis for protein transport through the Golgi and within the endoc

261 Monensin, an inhibitor of protein transport through the Golgi apparatus, blocks as

262 ordihydroguaiartic acid (NDGA), which blocks protein transport through the Golgi, were investigated.

263 he gene for a 55 kDa protein associated with protein transport through the inner chloroplast membrane

264 istor, whereby gate voltage mediates DNA and protein transport through the nanopore.

265 ng events and template the directionality of protein transport through the secretory and endocytic pa

266 ition of another major anabolic pathway, the protein transport through the secretory pathway, and to

267 of cisternal maturation matches the rate of protein transport through the secretory pathway, suggest

268 If protein transport through the SecYEG pore is the rate-li

269 tabolism, (ii) sporozoite biology, and (iii) protein transport to and from the host erythrocyte.

270 e second messenger Ca(2+), allowing membrane protein transport to be adjusted according to physiologi

271 counting of the cost in Gibbs free energy of protein transport to be undertaken.

272 mutants gfs3 and gfs12 with a defect in seed protein transport to PSV.

273 the GPI anchor or when we inhibited general protein transport to the cell surface, indicating that a

274 nction for the polarity protein Par6alpha in protein transport to the centrosome.

275 Cotranslational protein transport to the endoplasmic reticulum is contro

276 l signal sequence region of cdE2 affected E2 protein transport to the plasma membrane, while nonbuddi

277 uggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane.

278 ible roles for degradation and alteration of protein transport to the plasma membrane.

279 t, but not a PM-targeted GRK2ct, also blocks protein transport to the PM.

280 However, TGN protein transport to the PVC is accelerated in mutants l

281 of the need for electric fields in achieving protein transport to the substrate and confirmed experim

282 tin causes complex dissociation and triggers protein transport to the target organelle.

283 ythrocyte surface antigen (RESA), a parasite protein transported to the host spectrin network, on def

284 e used this approach to identify and compare proteins transported to synapses by kinesin (Kif) comple

285 otor kinesins to identify the populations of proteins transported to synapses.

286 lization of biosynthetic and endocytic cargo proteins transported to the multivesicular body (MVB).

287 This category of protein transport, together with the similar process tha

288 containing a deletion mutant of the C03H5.2 protein transport UDP-N-acetylglucosamine at rates compa

289 evertheless largely competent in anterograde protein transport using two different assays.

290 Similar to protein transport vesicles (PTVs), VTVs require coat com

291 Time-lapse imaging of synaptic vesicle protein transport vesicles (STVs) indicates that STVs pa

292 Nrxns comigrate as cargo on synaptic vesicle protein transport vesicles (STVs).

293 Kes1p also represses formation of protein transport vesicles from the trans-Golgi network

294 bstrates must be discriminated from those of proteins transported via other pathways.

295 secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pat

296 In this study, the role of DBC2 in protein transport was analyzed using vesicular stomatiti

297 he mechanism and energetics of bacterial Tat protein transport, we developed an efficient in vitro tr

298 ndoplasmic reticulum-to-Golgi and post-Golgi protein transports were impaired in betaIII spectrin-dep

299 rip coated with POEGMA facilitates effective protein transport while also confining the colorimetric

300 The former blocked G-protein transport, while the latter allowed transport to