ライフサイエンスコーパス: protein turnover

1 e enabled proteome-wide analyses of cellular protein turnover.

2 ted phosphorylation of Slug facilitates Slug protein turnover.

3 uced alterations in the regulation of muscle protein turnover.

4 Here, we show that glucose increases tomosyn protein turnover.

5 their action depends on concomitant synaptic protein turnover.

6 MDA receptors, L-VDCCs, CaMKII, and synaptic protein turnover.

7 ethods to systematically interrogate in vivo protein turnover.

8 cellular activities by executing the bulk of protein turnover.

9 t for SPP-mediated intramembrane cleavage in protein turnover.

10 lved in preprotein processing or Tic subunit protein turnover.

11 mutation rendered resistance to EGF-induced protein turnover.

12 t biochemical defects, including accelerated protein turnover.

13 of limited protein repair systems and slowed protein turnover.

14 involved in signal transduction and membrane protein turnover.

15 ncovered an apparent role for LON2 in matrix protein turnover.

16 Its turnover agreed with that of protein turnover.

17 is necessary and sufficient to promote Slbo protein turnover.

18 ytic plasticity and/or tighter regulation of protein turnover.

19 ng lysine 344 for alanine (K344A) prohibited protein turnover.

20 mic equilibrium (fasted losses-fed gains) in protein turnover.

21 tyrosine 262 enhanced the rate of the GADD34 protein turnover.

22 ction of lysosomes, which mediate autophagic protein turnover.

23 ited MYC gene expression and accelerated its protein turnover.

24 ill-defined catabolic alterations in muscle protein turnover.

25 which synaptic strength is preserved despite protein turnover.

26 l DNA binding domain [TraR(170-234)] enhance protein turnover.

27 tomegaly and hepatic steatosis, and impaired protein turnover.

28 ntrol of the ubiquitin proteasome system and protein turnover.

29 lysis of mass isotopomer patterns to measure protein turnover.

30 d that the E46K mutation does not alter aSyn protein turnover.

31 l if they occurred in unison to handle rapid protein turnover.

32 reveals genes involved in cell division and protein turnover.

33 itin E3 ligases in ubiquitin-mediated muscle protein turnover.

34 close homolog, PGC-1beta, influences muscle protein turnover.

35 rimarily at the level of translation and not protein turnover.

36 rences correlated to differences in rates of protein turnover.

37 ent manner, although ATP is required for the protein turnover.

38 is essential, but little is known about PCNA protein turnover.

39 responsible for the differences in rates of protein turnover.

40 growth, synapse formation, and intriguingly, protein turnover.

41 neously monitor dynamic S-palmitoylation and protein turnover.

42 to the inbred organisms' increased levels of protein turnover.

43 l additional phytohormones also regulate ACS protein turnover.

44 roliferation of cancer cells mandates a high protein turnover.

45 e of advanced prostate cancer by reducing AR protein turnover.

46 n-mediated proteolytic pathway for regulated protein turnover.

47 ife that undergoes rapid proteasome-mediated protein turnover.

48 -grade B-cell lymphoma characterized by high protein turnover.

49 rather than regulation of Csk mRNA levels or protein turnover.

50 usly anticipated in the global regulation of protein turnover.

51 ced activation, although it had no impact on protein turnover.

52 ession of Bim(EL), mainly through control of protein turnover.

53 artic acid, be used as a reliable measure of protein turnover.

54 iquitinating process in proteasome-dependent protein turnover.

55 nsible for most of the cytosolic and nuclear protein turnover.

56 SMAD2 protein as a consequence of increased protein turnover.

57 own to slow and enhance, respectively, Mcl-1 protein turnover.

58 t TM6SF2 expression by affecting the rate of protein turnover.

59 the mechanism of FBXO31-regulated cyclin D1 protein turnover.

60 identify USP9X as a key regulator of Themis protein turnover.

61 intracellular transport, cell signalling and protein turnover.

62 les or precludes its use for measurements of protein turnover.

63 velopment, requires ubiquitination-dependent protein turnover.

64 itin and K63-ubiquitin, central mediators of protein turnover.

65 h enhances cell survival by accelerating Bim protein turnover.

66 ds are well known to be key effectors of gut protein turnover.

67 hibition was not a result of changes in NOXA protein turnover.

68 loric restriction or rapamycin) that altered protein turnover (42 conditions in total).

69 Protein turnover also informs of biomarker kinetics, as

70 l decrease in protein level, suggesting that protein turnover also plays a critical role in TSC regul

71 r attempts to show that the higher levels of protein turnover among inbred organisms can be attribute

72 Previously, we showed that protein turnover and activity are tightly linked through

73 WTX knockdown accelerates CBP/p300 protein turnover and attenuates this modification of p53

74 mice with immunofluorescence for markers of protein turnover and autophagy.

75 post-Golgi vesicles, thereby influencing its protein turnover and axon protective capacity.

76 Through analysis of protein turnover and by disrupting different steps in th

77 l death in mitotically competent tissues and protein turnover and cellular repair in postmitotic tiss

78 g pulse-chase analysis, we characterized SMN protein turnover and confirmed that SMN was ubiquitinate

79 g trajectories are important in the study of protein turnover and dynamics, in which label incorporat

80 ther with specific hallmarks associated with protein turnover and epigenetics.

81 Protein turnover and homeostasis are regulated by the pr

82 We found that polyQ-AR reduced long-term protein turnover and impaired autophagic flux in motor n

83 esulting in inhibition of autophagy-mediated protein turnover and impaired degradation of internalize

84 in mass by appropriate stimulation of muscle protein turnover and inhibition of protein breakdown.

85 d caveolae, which functions in both membrane protein turnover and intracellular signaling.

86 roteasome system plays a significant role in protein turnover and may be involved in these posttransc

87 hese results suggest that ubiquitin-mediated protein turnover and MURF2 in particular play an unrecog

88 re hypothesized to play an important role in protein turnover and nuclear remodeling in HSV-1-infecte

89 has a modulating effect on both steady-state protein turnover and on ubiquitination induced by TNF-al

90 cal signaling properties in spite of ongoing protein turnover and perturbations to activity?

91 results implicate AIP-1 in the regulation of protein turnover and protection against Abeta toxicity a

92 ssion of Spop was able to restore proper Gli protein turnover and rescue phenotypes in Dzip1-depleted

93 Given the challenges of both normal channel protein turnover and short-term plasticity, how is the b

94 ect of enteral protein feeding on whole-body protein turnover and studied critically ill patients rec

95 employed by the UBA6-USE1 cascade to promote protein turnover and suggests that the UBA6 and UBA1 pat

96 ing LTP maintenance, in the midst of ongoing protein turnover and synaptic activity, remain elusive.

97 Whole-body protein turnover and the contribution of dietary protein

98 at plays a role in many processes, including protein turnover and the remodeling of macromolecular co

99 ge in color, which can be exploited to study protein turnover and trafficking.

100 cluding the regulation of signalling events, protein turnover and transcription, sometimes with confl

101 ets proteasome biogenesis to control overall protein turnover and tumor cell proliferation.

102 WWP2-C have a preference for Smad7 based on protein turnover and ubiquitination studies.

103 er K146 or K171 is required for iron-induced protein turnover, and 35S-IRT1K146R,K171R plants contain

104 possibility of heterozygous cell selection, protein turnover, and deletion efficiency with no succes

105 ing in mitochondrial protein ubiquitylation, protein turnover, and disease.

106 en energy status, protein intake, and muscle protein turnover, and explores future research directive

107 utations in genes involved in cell division, protein turnover, and glutamate transport.

108 oxidative damage of the reaction center, D1 protein turnover, and inhibition of electron transfer.

109 d post-steady state exercise MPS, whole-body protein turnover, and mammalian target of rapamycin 1 (m

110 eceptor trafficking, local mRNA translation, protein turnover, and new gene synthesis.

111 n lipid, glucose, and xenobiotic metabolism, protein turnover, and redox balance, as revealed by hepa

112 genes implicated in chloroplast biogenesis, protein turnover, and stress.

113 cate that apical patterning requires Aux/IAA protein turnover, and that apical domain auxin response

114 at matriptase enhances the rate of claudin-2 protein turnover, and that this is mediated indirectly t

115 ritical illness on muscle morphology, muscle protein turnover, and the associated muscle-signaling pa

116 ling is critical to the regulation of muscle protein turnover, and this regulation depends on suppres

117 ligase complexes that lead to alterations in protein turnover are important mechanisms in driving tum

118 ctors that control the dynamics of regulated protein turnover are largely unknown.

119 When relatively high rates of protein turnover are maintained despite advancing age, d

120 Although the basal rates of protein turnover are not altered with aging, age is asso

121 e on the regulation of human skeletal muscle protein turnover are not well described.

122 d threonine and their relation to whole-body protein turnover are presented.

123 Its effects on protein turnover are substrate-specific, for unknown rea

124 but additional levels of control, including protein turnover, are also essential for proper function

125 These two processes govern cellular protein turnover, are tightly regulated, and are modulat

126 ar processes, cell cycle, RNA-processing and protein turnover as cells acquire neural fate.

127 , which in turn increased ubiquitination and protein turnover, as well as decreased activity.

128 RT-PCR quantification of message levels and protein turnover assays indicate that up-regulation of c

129 tic transmission is facilitated by efficient protein turnover at lysosomes and identify a potential s

130 trates that help to maintain the dynamism of protein turnover at the IS.

131 However, little is known about ERM protein turnover at the membrane-cortex interface.

132 ndplate swellings may be caused by decreased protein turnover at the synapse.

133 Interestingly, increased protein turnover attenuates ROS levels and this novel an

134 dying cell membrane trafficking and membrane protein turnover because they render exo-/endocytosis-as

135 as been considered to play a primary role in protein turnover but not in catalytic activity.

136 a suggest that the UPS not only orchestrates protein turnover, but also dynamically regulates the act

137 and stretch have different effects on muscle protein turnover, but little is known about the metaboli

138 several hours after PERIOD and CRYPTOCHROME protein turnover, but the mechanism underlying this proc

139 eurons presents a challenge for the study of protein turnover, but the understanding of protein turno

140 rily lysosomal proteases involved in general protein turnover, but they also have specific proteolyti

141 l peptides are liberated during constitutive protein turnover, but this conflicts with the observatio

142 The N-terminus and SID equally enhance SR protein turnover by altering the stability of several ca

143 data suggest that CCP1/Nna1 plays a role in protein turnover by cleaving proteasome-generated peptid

144 27 plays a dual role in the regulation of D1 protein turnover by facilitating cotranslational biosynt

145 Here we quantify protein turnover by feeding animals with a (15)N-labelle

146 Our data suggest that the regulation of Wnd protein turnover by Hiw can function as a damage surveil

147 Cullin-Ring ubiquitin ligases regulate protein turnover by promoting the ubiquitination of subs

148 med the utility of the SNAP-tag for studying protein turnover by pulse-chase labelling.

149 ing cellular proliferation, development, and protein turnover by the proteasome.

150 uggest the novel idea that accelerated cMLCK protein turnover by the ubiquitin-proteasome system unde

151 ion of HIV-1-associated alterations in brain protein turnover by the ubiquitin-proteasome system was

152 lpain activation contribute to the demise of protein turnover by the ubiquitin/proteasome pathway.

153 Alterations of CYP3A4 protein turnover can influence clinically relevant drug

154 resistance is to inhibit other steps in the protein turnover cascade mediated by the proteasome.

155 llular processes including stress responses, protein turnover, cell growth, and ribosome biogenesis.

156 nctions, such as translation, transcription, protein turnover, cell growth, differentiation, cell sur

157 tile organelles, involved in many aspects of protein turnover, cellular homeostasis, membrane traffic

158 Protein ubiquitination plays key roles in protein turnover, cellular signaling, and intracellular

159 pon completion of cell division and that the protein turnover characteristics of CSLD5 are altered in

160 Consistent with their crucial role in protein turnover, ClpP, HslV, and FtsH affect a number o

161 nctive responses of diabetes-induced retinal protein turnover compared with muscle and liver that may

162 The Ser --> Asp mutant had enhanced protein turnover compared with the Ser --> Ala mutant an

163 ntrast, we observed indications of decreased protein turnover, concomitant with heightened DNA repair

164 Together, our results suggest that Dia2 protein turnover does not involve an autocatalytic mecha

165 n, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent

166 Altered protein turnover due to impaired COP1 function led to ac

167 ns lacking eEF1Bgamma show severe defects in protein turnover during conditions of oxidative stress.

168 ether Adam9 regulates PMN recruitment or ECM protein turnover during inflammatory responses, we compa

169 rom this information, we have calculated the protein turnover energy costs in different leaves and th

170 ise on the molecular substrates that control protein turnover following brain trauma.

171 However, despite the importance of SV protein turnover for neuronal health, the molecular mech

172 lated by high iron, 24 proteins had elevated protein turnover for the cells in the high-iron medium.

173 a data analysis tool, DeuteRater, to measure protein turnover from metabolic D 2 O labeling.

174 ty in clpc1 results in a reduced rate of PSY protein turnover, further supporting the role of Clp pro

175 plification, novel protein interactions, and protein turnover has progressed rapidly.

176 autophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegene

177 These results suggest that disruption of protein turnover homeostasis via ribosome or proteasome

178 method exists for the measurement of global protein turnover (i.e., proteome dynamics) that can be a

179 ing a time-resolved map of insulin-regulated protein turnover in adipocytes using metabolic pulse-cha

180 Modulating protein turnover in ATM-depleted cells also has an adver

181 Pulse-chase experiments indicated decreased protein turnover in beta-cells treated with PA/glucose.

182 e important for understanding of the role of protein turnover in cellular and organism health as well

183 ing recognized as important in regulation of protein turnover in eukaryotic cells.

184 Here we show that, despite rapid Cdt1 protein turnover in G2 phase, Geminin promotes Cdt1 accu

185 in vivo studies in understanding the role of protein turnover in genotype/phenotype relationships and

186 Subcellular compartments with fast protein turnover in HeLa and HEK293T cells, and newly gr

187 Here, we report a widespread increase in protein turnover in HGPS-derived cells compared to norma

188 effect of heme on the rate of mature ALAS-1 protein turnover in human cells and tissues and explored

189 8Q) mutant is also responsible for increased protein turnover in human erythroid cells.

190 B has many house-keeping functions, such as protein turnover in lysosomes.

191 etermined the relative protein abundance and protein turnover in M. tuberculosis H37Rv under these tw

192 f protein turnover, but the understanding of protein turnover in neurons and its modulation in respon

193 on with age, the effect of obesity on muscle protein turnover in older adults remains unknown.

194 morphology, we discuss the relevance of mDia protein turnover in other processes where ubiquitin-medi

195 ophila to compare the rates of mitochondrial protein turnover in parkin mutants, PINK1 mutants, and c

196 fect of tumor burden and resection on muscle protein turnover in patients with nonmetastatic colorect

197 chromatography-mass spectrometry studies of protein turnover in plants.

198 inase USP9x regulate cytokine-mediated MCL-1 protein turnover in rodent beta-cells.

199 Thus, measuring protein turnover in stressed Mycobacterium cells has imp

200 cathepsin activities and rates of autophagic protein turnover in TgCRND8 mice by genetically deleting

201 f degradation and is the primary mediator of protein turnover in the cell.

202 xpression of ASB11 can increase Ribophorin 1 protein turnover in vivo.

203 re enriched in a number of key regulators of protein turnover, including ubiquitin, VCP/p97 and prote

204 r structural cohesion contributes to reduced protein turnover, increasingly abnormal proteostasis and

205 Further analysis of protein turnover indicated that the half-life of Zip14 i

206 ences aligned with divergences in lean mass, protein turnover, insulin sensitivity and the molecular

207 Dysfunction of protein turnover is a feature of many human diseases, an

208 Protein turnover is a key component in cellular homeosta

209 Protein turnover is a key process for bacterial survival

210 This suggests that protein turnover is a sensitive parameter to assess the

211 Protein turnover is an important metabolic and regulator

212 Rapid Myc protein turnover is critical for maintaining basal level

213 Control of protein turnover is critical for meiotic progression.

214 Accurate measurement of muscle protein turnover is critical for understanding the physi

215 Regulation of protein turnover is essential to the survival of eukaryo

216 Knowledge of rates of protein turnover is important for a quantitative underst

217 Protein turnover is important for general health on cell

218 ated transcription of SYT11, while increased protein turnover is regulated by SYT11 ubiquitination an

219 Therefore, we hypothesized that retinal protein turnover is regulated differently than in other

220 Proper protein turnover is required for cardiac homeostasis and

221 Here, we show that increased protein turnover is responsible for the reduced cellular

222 s near completely labeled in a few hours and protein turnover is the limiting factor in establishing

223 study provides an example of how changes in protein turnover kinetics can be used to detect physiolo

224 MLN4924 disrupts cullin-RING ligase-mediated protein turnover leading to apoptotic death in human tum

225 Cellular mechanisms involving protein turnover may be key defense mechanisms against a

226 Notably, we found that NS3 protein turnover may vary in ovine but not in Culicoides

227 remove noise and increase confidence in the protein turnover measurement for each protein.

228 cence, and identifies a p53 isoform-specific protein turnover mechanism that orchestrates p53-mediate

229 possible investigations of poorly understood protein turnover mechanisms at the inner nuclear membran

230 a suggest that autophagy, and its consequent protein turnover, mediate the acquisition of the senesce

231 Regulation of protein turnover mediated by ZEITLUPE (ZTL) constitutes

232 otein, AtCHIP, also plays important roles in protein turnover metabolism.

233 inated in the cellular environment and their protein turnover must be regulated via an alternate path

234 Little is known about the rate at which protein turnover occurs in living tendon and whether the

235 Furthermore, Pin1 promotes protein turnover of APP by inhibiting GSK3beta activity.

236 Mechanistically, ARF knockdown suppressed protein turnover of beta-catenin/YAP, and therefore enha

237 promotes polyubiquitination and accelerates protein turnover of CaV2.1.

238 ly, EGF was found to be capable of promoting protein turnover of epithelial protein lost in neoplasm

239 toxin has no effect on the transcription or protein turnover of HIF-1alpha, but instead it acts to i

240 ation of TRIM56 abundance did not affect the protein turnover of N(pro) and IRF3.

241 ly parallel multiplexing strategy to monitor protein turnover on a global scale by coupling flow cyto

242 dings show that RNA CCUG repeats misregulate protein turnover on both the levels of translation and p

243 stem were specifically impaired in PAA2/HMA8 protein turnover on media containing elevated copper con

244 lation and degradation of kinases in regular protein turnover or during stress when kinases are denat

245 AMP-2A and Hsc73, key components of the host protein turnover pathway known as chaperone-mediated aut

246 gled residues within the conserved IE govern protein turnover, presumably through interactions with E

247 ariety of biological signal transduction and protein turnover processes.

248 We determined the global protein turnover profiles for Mycobacterium smegmatis un

249 wo time intervals, gene networks involved in protein turnover, protein phosphorylation, molecular tra

250 The protein turnover quantitation experiments and computatio

251 We observed that Rad17 protein turnover rate in breast epithelial cells is much

252 rsibility of the inhibition and the very low protein turnover rate observed for the enzyme are partic

253 Low light conditions increased SAUR63:HA protein turnover rate.

254 ing within the isotope envelope to calculate protein turnover rate.

255 e role of the host-specific variation in NS3 protein turnover rate.

256 , creating a reference dataset of 496 plasma protein turnover rates from 4 healthy adults.

257 ates in rats in vivo, measure variability of protein turnover rates in any animal model, and utilize

258 quilibria, possibly relating to the modified protein turnover rates in heterotrophic plastids.

259 study is the first to measure global plasma protein turnover rates in rats in vivo, measure variabil

260 Analysis of in vitro degradation rates and protein turnover rates in vivo of specific proteins indi

261 g stage, where measurement of amino acid and protein turnover rates is accomplished using a heavy wat

262 Measured protein turnover rates will be important for understandi

263 However, these mutants displayed a defect in protein turnover rates.

264 ich in many cases are mediated by changes in protein turnover rates.

265 differential equations was used to calculate protein turnover rates.

266 hesis, increased because of stabilization of protein turnover rather than transcriptional activation.

267 tween mRNA stability regulated by PABPN1 and protein turnover regulated by ARIH2.

268 ophagy, a cellular process for organelle and protein turnover, regulates innate immune responses.

269 Increased protein turnover renders mesenchymal sub-populations hig

270 Therefore, maintenance of protein turnover represents an important proteostatic me

271 We assessed muscle NF-kappaB activity and protein turnover signaling in progressive stages of clin

272 significant overall slowing of mitochondrial protein turnover, similar to but less severe than the sl

273 lysosomal degradation, accompanied by a high-protein-turnover state.

274 ies, including translation, respiration, and protein turnover, stimulate behavioral avoidance of norm

275 Protein turnover studies on a proteome scale based on me

276 Protein turnover study revealed that overexpression of I

277 HE1 has a key function in situations of high protein turnover, such as seed production and the use of

278 ate that c-MYC is a target of CRY2-dependent protein turnover, suggesting a molecular mechanism for c

279 cits and reduce function of two of the major protein turnover systems: autophagy and proteasome.

280 repression also involves modulation of REST protein turnover through actions on the ubiquitin ligase

281 Protein turnover through cullin-3 is tightly regulated b

282 processes and is hypothesized to facilitate protein turnover, thus promoting further DNA processing.

283 pathway that mechanistically links misfolded protein turnover to components of the systemic RNAi mach

284 ing of an important regulatory loop, linking protein turnover to gene regulation.

285 ne of the proteome, cells use the process of protein turnover to replace potentially impaired polypep

286 which act by distinct mechanisms, including protein turnover, transcription complex formation and se

287 we link Dubs to diverse processes, including protein turnover, transcription, RNA processing, DNA dam

288 eins, respectively, are capable of normal D1 protein turnover under moderate growth light intensity.

289 microvascular blood volume (MBV) and muscle protein turnover under post-absorptive and fed state (i.

290 eral platform for proteome-scale analysis of protein turnover under various physiological and disease

291 eased SCCA expression leads to inhibition of protein turnover, unfolded protein response, activation

292 proteins and participate in plasma membrane protein turnover, vacuolar/lysosomal hydrolase delivery,

293 MPS and whole-body protein turnover were determined by using primed continu

294 ression, and those relating to chaperone and protein turnover were overrepresented in the genes with

295 s of feed utilisation such as metabolism and protein turnover were the reason for change in REI.

296 pression of CDK inhibitors and decreased p53 protein turnover, which blocked their tumorigenic capaci

297 1/EOLs in vivo plays a role in mediating ACS protein turnover, with increased levels leading to a dec

298 likely due to the exocrine function and high protein turnover within the pancreas.

299 GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription.

300 not regulated by transcription but rather by protein turnover: ZFP809 protein is stable in embryonic