ライフサイエンスコーパス: protein tyrosine phosphatase 1B

1 T receptor activation through recruitment of protein tyrosine phosphatase 1B.

2 cting ligands of an allosteric pocket of the protein tyrosine phosphatase 1B.

3 photoreceptors against dephosphorylation by protein tyrosine phosphatase 1B.

4 1 over VH-1-related phosphatase, Cdc25B2, or protein-tyrosine phosphatase 1B.

5 in part by a reduction in the expression of protein-tyrosine phosphatase 1B.

6 yrosine phosphatase-alpha over the cytosolic protein-tyrosine phosphatase-1B.

7 reased skeletal muscle protein expression of protein-tyrosine phosphatase 1B (a negative regulator of

8 a chemical library of 704 compounds against protein tyrosine phosphatase 1B, a diabetes, obesity, an

9 Inhibition of protein tyrosine phosphatase 1B abrogated cAMP-mediated

10 -src) cleavage, but not early events such as protein-tyrosine phosphatase-1B activation.

11 ial signaling and its consequences depend on protein-tyrosine phosphatase 1B activity.

12 phosphorylation of autophosphorylated Src by protein tyrosine phosphatase 1B allowed Src to be inacti

13 Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl ci

14 enes for signal transduction proteins (e.g., protein tyrosine phosphatase 1B and regulatory subunits

15 ially S-oxidized and S-nitrosylated forms of protein tyrosine phosphatase 1B, as well as intact and l

16 NAFLD, including the histopathologic marker protein tyrosine phosphatase 1b, AST/ALT ratio, gamma-gl

17 agents initiated the proteolytic cleavage of protein tyrosine phosphatase 1B by calpain.

18 equired functionally active A1AT protein and protein tyrosine phosphatase 1B expression.

19 translocation, which is reversed by reducing protein tyrosine phosphatase 1B expression.

20 ase expression and correlated with increased protein-tyrosine phosphatase 1B expression.

21 , inhibiting the phosphotyrosine phosphatase protein tyrosine phosphatase 1B further stimulated insul

22 rylation of insulin receptor substrate-1 and protein tyrosine phosphatase-1B gene expression and the

23 Thus protein-tyrosine phosphatase 1B governs differential rec

24 nalysis, leukocyte antigen related (LAR) and protein-tyrosine phosphatase 1B had the greatest increas

25 NA levels, protein mass, and activity of the protein-tyrosine phosphatase-1B implicated in the attenu

26 Crystal structures of protein-tyrosine phosphatase 1B in complex with compound

27 hat both the native and the cleaved forms of protein tyrosine phosphatase 1B interact with p130(Cas)

28 Enzymatic cleavage of protein tyrosine phosphatase 1B occurs near the endoplas

29 o enzyme inhibition (glycogen phosphorylase, protein tyrosine phosphatase 1B) or by inhibiting renal

30 ould affect selectivity for CD45 over PTP1B (protein tyrosine phosphatase 1B) or vice versa.

31 Third, protein tyrosine phosphatase 1B preferentially dephospho

32 eraldehyde-3-phosphate dehydrogenase, HSP27, protein-tyrosine phosphatase 1B, protein kinase Calpha,

33 ogen synthase kinase-3beta, forkhead box O1, protein-tyrosine phosphatase-1B, PTEN (phosphatase and t

34 Protein tyrosine phosphatase 1B (PTP-1B) has been implic

35 c but enhanced the Ser-50 phosphorylation of protein tyrosine phosphatase 1B (PTP-1B) with a concomit

36 ro inhibition data against recombinant human protein tyrosine phosphatase 1B (PTP-1B).

37 osphotyrosine (pY) under the assistance of a protein tyrosine phosphatase-1B (PTP-1B).

38 Here we report that protein-tyrosine phosphatase 1B (PTP 1B) is an alpha-act

39 uppressor of cytokine signaling (SOCS)-3 and protein-tyrosine phosphatase 1B (PTP-1B) are two endogen

40 Protein-tyrosine phosphatase 1B (PTP-1B) is a major prot

41 The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), w

42 late radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and b

43 g with assays of zinc content was related to protein tyrosine phosphatase 1B (PTP1B) and extracellula

44 aling and reduced levels of the phosphatases protein tyrosine phosphatase 1B (PTP1B) and phosphatase

45 Protein tyrosine phosphatase 1B (PTP1B) and SH2 domain-c

46 e of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of le

47 We identified protein tyrosine phosphatase 1B (PTP1B) as a major targe

48 There has been considerable interest in protein tyrosine phosphatase 1B (PTP1B) as a therapeutic

49 We have recently shown that protein tyrosine phosphatase 1B (PTP1B) associates with

50 Protein tyrosine phosphatase 1B (PTP1B) attenuates insul

51 ued by expression of a truncated fragment of protein tyrosine phosphatase 1B (PTP1B) corresponding to

52 Protein tyrosine phosphatase 1B (PTP1B) counteracts lept

53 Protein tyrosine phosphatase 1B (PTP1B) displays a prefe

54 Protein tyrosine phosphatase 1B (PTP1B) has been implica

55 Protein tyrosine phosphatase 1B (PTP1B) has been implica

56 Protein Tyrosine phosphatase 1B (PTP1B) has been implica

57 To investigate the role of nonreceptor protein tyrosine phosphatase 1B (PTP1B) in beta1-integri

58 In this report, we identify a role for protein tyrosine phosphatase 1B (PTP1B) in the VCAM-1 si

59 ries of azolidinediones has been prepared as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

60 Protein tyrosine phosphatase 1B (PTP1B) is a negative re

61 Protein tyrosine phosphatase 1B (PTP1B) is a negative re

62 Protein tyrosine phosphatase 1B (PTP1B) is a protein tyr

63 Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitousl

64 Protein tyrosine phosphatase 1B (PTP1B) is a validated t

65 Protein tyrosine phosphatase 1B (PTP1B) is an abundant i

66 Protein tyrosine phosphatase 1B (PTP1B) is an enzyme tha

67 at increased NO production via inhibition of protein tyrosine phosphatase 1B (PTP1B) is associated wi

68 Protein tyrosine phosphatase 1B (PTP1B) is implicated as

69 Protein tyrosine phosphatase 1B (PTP1B) is implicated in

70 Protein tyrosine phosphatase 1B (PTP1B) is implicated in

71 Protein tyrosine phosphatase 1B (PTP1B) is postulated to

72 Protein tyrosine phosphatase 1B (PTP1B) negatively regul

73 Protein tyrosine phosphatase 1B (PTP1B) plays important

74 invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2

75 idic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived fro

76 A highly potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with a nanomolar

77 e we show how these pillars are connected in Protein Tyrosine Phosphatase 1B (PTP1B), a drug target f

78 Protein tyrosine phosphatase 1B (PTP1B), a major new pha

79 ran and benzothiophene biphenyl analogues of protein tyrosine phosphatase 1B (PTP1B), a target for in

80 tion machinery modulates an interaction with protein tyrosine phosphatase 1B (PTP1B), an ER-associate

81 rreversible sulphinic and sulphonic acids of protein tyrosine phosphatase 1B (PTP1B), an important en

82 imarily to transcriptional downregulation of protein tyrosine phosphatase 1B (PTP1B), an inhibitory p

83 omerase, nucleophosmin-1, chaperonin, actin, protein tyrosine phosphatase 1B (PTP1B), and glucosidase

84 gative inhibitor of insulin signaling, i.e., protein tyrosine phosphatase 1B (PTP1B), and increased p

85 SirT1, protein tyrosine phosphatase 1B (PTP1B), and PTP1B mutan

86 lpain-1 null (Capn1-/-) platelets accumulate protein tyrosine phosphatase 1B (PTP1B), which correlate

87 nalysis of the redox-dependent regulation of protein tyrosine phosphatase 1B (PTP1B), which is revers

88 of Ca2+/calpain and resulting activation of protein tyrosine phosphatase 1B (PTP1B).

89 ilize the oxidized, inactive conformation of protein tyrosine phosphatase 1B (PTP1B).

90 t, competitive, and reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B).

91 s implications for the in vivo regulation of protein tyrosine phosphatase 1B (PTP1B, EC 3.1.3.48): th

92 Protein tyrosine phosphatase-1b (Ptp1b) inhibits insulin

93 signal termination is less well understood, protein tyrosine phosphatase-1B (PTP1B) is implicated in

94 Protein tyrosine phosphatase-1B (PTP1B) negatively regul

95 Based on in vitro and ex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was implicated i

96 to discover novel inhibitors for the enzyme protein tyrosine phosphatase-1B (PTP1B), a tyrosine phos

97 cell infiltration, expression of MMP-9, and protein tyrosine phosphatase-1B (PTP1B), which negativel

98 Here, we report that protein tyrosine phosphatases 1B (PTP1B) directly dephos

99 Structural analyses of the protein-tyrosine phosphatase 1B (PTP1B) active site and

100 s zinc transport into hepatocytes to inhibit protein-tyrosine phosphatase 1B (PTP1B) activity, which

101 epatocytes with or without expression of the protein-tyrosine phosphatase 1B (PTP1B) and in wild-type

102 enylalanine (F(2)Pmp)-containing peptides to protein-tyrosine phosphatase 1B (PTP1B) and its substrat

103 Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte an

104 Protein-tyrosine phosphatase 1B (PTP1B) and T cell prote

105 Previous studies suggested that protein-tyrosine phosphatase 1B (PTP1B) antagonizes insu

106 The approach was applied to protein-tyrosine phosphatase 1B (PTP1B) as a first examp

107 Neuronal protein-tyrosine phosphatase 1B (PTP1B) deficiency in mi

108 Protein-tyrosine phosphatase 1B (PTP1B) dephosphorylates

109 Protein-tyrosine phosphatase 1B (PTP1B) has been implica

110 Protein-tyrosine phosphatase 1B (PTP1B) has been implica

111 tically inactive mutant (C215S) of the human protein-tyrosine phosphatase 1B (PTP1B) has been solved

112 The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was

113 h as silencer of cell signaling 1 (SOCS1) or protein-tyrosine phosphatase 1B (PTP1B) in this process.

114 Protein-tyrosine phosphatase 1B (PTP1B) is a major negat

115 Protein-tyrosine phosphatase 1B (PTP1B) is a physiologic

116 Protein-tyrosine phosphatase 1B (PTP1B) is an important

117 Protein-tyrosine phosphatase 1B (PTP1B) is an important

118 Protein-tyrosine phosphatase 1B (PTP1B) is an ubiquitous

119 Catalysis by protein-tyrosine phosphatase 1B (PTP1B) occurs through a

120 aim of our work was to study the role of the protein-tyrosine phosphatase 1B (PTP1B) on the cellular

121 Protein-tyrosine phosphatase 1B (PTP1B) regulates food i

122 ermal growth factor (EGF) on the activity of protein-tyrosine phosphatase 1B (PTP1B) was investigated

123 We have demonstrated that protein-tyrosine phosphatase 1B (PTP1B) was underexpress

124 colocalization of S-nitrosothiol (S-NO) and protein-tyrosine phosphatase 1B (PTP1B), and Akt phospho

125 The expression and activity of the protein-tyrosine phosphatase 1B (PTP1B), but not protein

126 our candidate protein-tyrosine phosphatases (protein-tyrosine phosphatase 1B (PTP1B), SH2 domain-cont

127 -compound virtual library against the target protein-tyrosine phosphatase 1B (ptp1b).

128 tor-kappaB (NF-kappaB)-mediated induction of protein-tyrosine phosphatase 1B (PTP1B).

129 The protein-tyrosine phosphatase 1B (PTP1B; PTPN1) is an imp

130 Protein-tyrosine phosphatase-1B (PTP1B) has been implica

131 organic phosphate to the intracellular human protein tyrosine phosphatase 1B(PTP1B).

132 In response to insulin, protein-tyrosine phosphatase 1B (PTPase 1B) dephosphoryl

133 To understand the physiological role of protein-tyrosine phosphatase 1B (PTPase 1B) in insulin a

134 Here we show that protein-tyrosine phosphatase 1B (PTPIB) activates Src, t

135 VH1-related dual-specificity phosphatase or protein tyrosine phosphatase 1b, respectively.

136 Protein levels of protein tyrosine phosphatase-1B, Src homology phosphatas

137 The amount of protein tyrosine phosphatase-1B, Src homology phosphatas

138 had a significantly higher IRbeta-associated protein tyrosine phosphatase-1B than the mean of WL5 and

139 This interaction may serve to relocate protein tyrosine phosphatase 1B to sites of focal contac

140 we experimentally validate a cryptic site in protein tyrosine phosphatase 1B using a covalent ligand

141 Consistent with these observations, protein tyrosine phosphatase 1b was elevated in the y/y

142 Actin and protein tyrosine phosphatase 1B were identified in vitro

143 Both actin and protein-tyrosine phosphatase-1B were superior substrates

144 are distinctly different from those seen in protein tyrosine phosphatase 1B where a five-membered su

145 The PTPN1 gene encodes protein tyrosine phosphatase-1B, which is ubiquitously e

146 ave identified a small-molecule inhibitor of protein tyrosine phosphatase 1B with low micromolar inhi

147 Human placental protein tyrosine phosphatase 1B, with absolute specifici