ライフサイエンスコーパス: protein ubiquitination

1 subunit of SCF-type ubiquitin E3 ligases in protein ubiquitination.

2 ubiquitin chains and reverses the process of protein ubiquitination.

3 ls during axonal and synaptic development is protein ubiquitination.

4 results reveal a fast regulated turnover of protein ubiquitination.

5 large-scale analysis and characterization of protein ubiquitination.

6 Ubp3p has a general role in the reversal of protein ubiquitination.

7 late diverse cellular processes by mediating protein ubiquitination.

8 inheritance, and reveal a novel function for protein ubiquitination.

9 s that permitted their use in reconstituting protein ubiquitination.

10 -AP) gene, the product of which functions in protein ubiquitination.

11 d to other proteins in a manner analogous to protein ubiquitination.

12 E1a in the nucleus and may modulate nuclear protein ubiquitination.

13 cytosed bacilli to exosomes was dependent on protein ubiquitination.

14 ilities of IDRs in the regulation of dynamic protein ubiquitination.

15 SOCS box-containing protein 2 facilitates E protein ubiquitination.

16 te various cellular processes by controlling protein ubiquitination.

17 role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.

18 At DSBs, CHFR regulates the first wave of protein ubiquitination.

19 that down-regulation of Rnd3 attenuated NICD protein ubiquitination.

20 was shown to induce degradation of LDLR via protein ubiquitination.

21 lls exhibited a Triad1-dependent increase in protein ubiquitination.

22 acellular calcium signaling to regulation of protein ubiquitination.

23 e that regulate the targeting specificity of protein ubiquitination.

24 ere with Ub-E2 and E3 interaction to inhibit protein ubiquitination.

25 SCF(Fbx4) (the superscript denotes the F-box protein) ubiquitination activity toward the telomere reg

26 of the heat shock response to the extent of protein ubiquitination after heat shock.

27 RNA sequencing and protein ubiquitination analysis of the agroinfiltrated N

28 enance, but the critical pathways regulating protein ubiquitination and degradation are incompletely

29 In parallel, GLIPR1 also promoted c-Myc protein ubiquitination and degradation by glycogen synth

30 tion factors is essential to initiate muscle protein ubiquitination and degradation during atrophy.

31 nly the ITAM-containing domain also directed protein ubiquitination and degradation in the absence of

32 Additional LPS treatment promoted protein ubiquitination and degradation of LKB1.

33 reveals that a super-low dose of LPS causes protein ubiquitination and degradation of mitofusin 1 (M

34 These data suggest that the KFB-mediated protein ubiquitination and degradation regulates the pro

35 sponses, detection and repair of DNA damage, protein ubiquitination and degradation, mitogenic signal

36 ins, resulting in enhanced c-Cbl-mediated FA protein ubiquitination and degradation, myofibril degrad

37 opmental processes through the regulation of protein ubiquitination and degradation.

38 to facilitate their recruitment in mediating protein ubiquitination and degradation.

39 ry aspect of eukaryotic biology by promoting protein ubiquitination and degradation.

40 3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation.

41 Protein ubiquitination and deubiquitination are both med

42 farction accompanied by an increase in total protein ubiquitination and enhanced proteasome activity,

43 eIF2 alpha-kinase, and induction of hepatic protein ubiquitination and ER chaperones Grp78 and Grp94

44 lnerability to oxidative stress and elevated protein ubiquitination and exhibited disease-associated

45 to arginines led to an altered pattern of M protein ubiquitination and impaired viruslike particle (

46 ally, these studies demonstrate that reduced protein ubiquitination and increased protein stability l

47 ter APAP treatment followed by mitochondrial protein ubiquitination and mitophagy induction.

48 ng enzymes (DUBs) are negative regulators of protein ubiquitination and play an important role in ubi

49 ganisms, suggesting that UBC1 is involved in protein ubiquitination and possibly degradation during D

50 Thus we establish nuclear E1-dependent protein ubiquitination and propose that an increase in p

51 The frequently observed correlation between protein ubiquitination and proteasomal degradation is in

52 plex formation, which in turn triggers DELLA protein ubiquitination and proteolysis via the SCF(SLY1)

53 viral defense through cascades controlled by protein ubiquitination and Ser/Thr phosphorylation.

54 Protein ubiquitination and subsequent degradation by the

55 ction program in macrophages that stimulates protein ubiquitination and the degradation of regulators

56 ch as vesicle formation, mRNA stability, and protein ubiquitination and trafficking.

57 79, 80, 130, and 247 to arginines restored M protein ubiquitination and VLP production, suggesting th

58 of specific substrates, generally increased protein ubiquitination, and accelerated protein turnover

59 icking, protein or lipid phosphorylation and protein ubiquitination, and affect autophagosome number

60 ffect on intracellular proteasome content or protein ubiquitination, and did not increase the vulnera

61 ow less urea-induced protein unfolding, less protein ubiquitination, and higher proteasome activity.

62 olism, in gluconeogenesis and glycolysis, in protein ubiquitination, and in insulin, interleukin-4, e

63 and subsequent development requires specific protein ubiquitination, and possibly degradation.

64 The results revealed an increase in protein ubiquitination, and specifically LCK ubiquitinat

65 rapamycin (mTOR) targets, autophagy markers, protein ubiquitination, and the intracellular amino acid

66 ns, including doa4 and ubc4, that compromise protein ubiquitination, and these ubiquitination defects

67 is enhanced proteasomal degradation required protein ubiquitination, and within 30 min after mTOR inh

68 ), (iv) proteasome impairment with increased protein-ubiquitination, and (v) oxidative stress with gl

69 olved in cell cycle, cell cycle checkpoints, protein-ubiquitination, and apoptosis were altered.

70 anization, actin filament-based process, and protein ubiquitination are associated with meat tenderne

71 suggesting that the observed alterations in protein ubiquitination are specific to the apoptotic pro

72 lational modifications (PTMs), which include protein ubiquitination, are critically involved in anima

73 se studies have identified the regulation of protein ubiquitination as a novel function of Hox transc

74 , these data validate proteomic profiling of protein ubiquitination as a viable approach for identify

75 In this study we have explored protein ubiquitination as one potential mechanism for th

76 As Hsp27 has well-characterized roles in protein ubiquitination as well as in adhesion-induced cy

77 el strategy for determining posttraslational protein ubiquitination based on the N-terminal sulfonati

78 n-like protein NEDD8 (neddylation) regulates protein ubiquitination by promoting the assembly of cull

79 y with beta-TrCP1 and significantly elevated protein ubiquitination by SCF(beta-TrCP1).

80 The completion of mitosis depends on protein ubiquitination by the anaphase-promoting complex

81 As with phosphorylation, protein ubiquitination can be reversed, through the acti

82 sine selection is a long-standing problem in protein ubiquitination catalyzed by the RING ubiquitin l

83 ncluding cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcrip

84 Protein ubiquitination controls protein stability and su

85 roliferation, c-Myc and CUL1 expression, and protein ubiquitination/degradation in IgM-stimulated B6

86 By countering protein ubiquitination, deubiquitinating enzymes (DUBs)

87 Because protein ubiquitination, especially polyubiquitination, c

88 Temporal profiling of protein ubiquitination events across a series of time po

89 try enables the in-depth characterization of protein ubiquitination events at the site-specific level

90 ncreased diaphragm interleukin-6 production, protein ubiquitination, expression of Atrogin-1 and Murf

91 umber of cellular signaling pathways utilize protein ubiquitination for activation of signaling casca

92 We found an overall reduction of protein ubiquitination, free ubiquitin, K48-linked ubiqu

93 Protein ubiquitination has been implicated in many impor

94 Protein ubiquitination has been implicated in the intrac

95 Protein ubiquitination has been implicated in the regula

96 Protein ubiquitination has been implicated recently in n

97 Disordered protein ubiquitination has been linked to neurodegenerat

98 ght protein ubiquitin to substrate proteins (protein ubiquitination) has proven to be yet another wid

99 1 inhibits proteasomal degradation distal to protein ubiquitination in a BAG domain-dependent manner.

100 The discovery of protein ubiquitination in a broad range of organisms and

101 evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag f

102 To understand the dynamic role of protein ubiquitination in biological processes, robust t

103 E3 ligase Rsp5, and demonstrate a role for G protein ubiquitination in cell polarization.

104 DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and

105 the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in diverse cellular functions, in

106 The SCF ubiquitin ligases catalyze protein ubiquitination in diverse cellular processes.

107 t makes only a minor contribution to overall protein ubiquitination in HeLa cell extracts.

108 otential roles of mitochondrial function and protein ubiquitination in oxidative stress resistance.

109 We propose a new function for protein ubiquitination in regulating the activity of cer

110 itation experiments were performed to assess protein ubiquitination in T cell lysates.

111 ngs demonstrate that PJA1 can be involved in protein ubiquitination in the brain and is a suitable ca

112 These bat species also show low levels of protein ubiquitination in total protein lysates along wi

113 ing enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction b

114 Protein ubiquitination involves E1, E2, and E3 trienzyme

115 The central chemical step in Lys 63-linked protein ubiquitination involves the reaction of a specif

116 Protein ubiquitination is a common form of post-translat

117 Protein ubiquitination is a core regulatory determinant

118 Protein ubiquitination is a highly versatile post-transl

119 Protein ubiquitination is a key regulatory process essen

120 Protein ubiquitination is a post-translational modificat

121 Protein ubiquitination is a post-translational modificat

122 Protein ubiquitination is a powerful regulatory modifica

123 Protein ubiquitination is a versatile protein modificati

124 Protein ubiquitination is a widespread protein posttrans

125 rotein to UBCs, the developmental pattern of protein ubiquitination is altered in ubcB-null cells.

126 Protein ubiquitination is an important regulator of cyto

127 Protein ubiquitination is catalyzed by ubiquitin-conjuga

128 Protein ubiquitination is controlled by the coordinate a

129 Recent findings suggest that protein ubiquitination is crucial for proper regulation

130 The specificity of protein ubiquitination is determined by E3 ubiquitin lig

131 d at a lesion site, and Rad6-Rad18-dependent protein ubiquitination is important for polymerase excha

132 Protein ubiquitination is mediated sequentially by ubiqu

133 Protein ubiquitination is one of the most powerful postt

134 atabolic signalling via forkhead box O 1 and protein ubiquitination is SIRT1 dependent.

135 Since protein ubiquitination is the predominant sorting signal

136 al that, in a cellular context, mislocalized protein ubiquitination is the result of a dynamic equili

137 While protein ubiquitination is utilized for many cellular pro

138 cation, whereas the HECT domain, involved in protein ubiquitination, is not necessary for Rsp5p-media

139 Although TRIM32 is involved in protein ubiquitination, its substrates and the molecular

140 ubiquitination, suggesting that presynaptic protein ubiquitination makes a crucial contribution to t

141 In nerve terminals, protein ubiquitination may play a role both in the regul

142 These results indicate that protein ubiquitination mediated by Rsp5p plays an essent

143 VEGF and PKC promote degradation-independent protein ubiquitination of FLNB to control intracellular

144 s mechanism, resulting in elevated levels of protein ubiquitination on mTOR activation.

145 h was not associated with increase in global protein ubiquitination or unfolded protein response indu

146 ciated with the acute-phase response and the protein ubiquitination pathway were enriched during infe

147 opic COP/DET/FUS group of proteins defined a protein ubiquitination pathway.

148 In addition, protein ubiquitination plays a regulatory role in the im

149 Protein ubiquitination plays a role in essentially every

150 Protein ubiquitination plays an essential regulatory rol

151 Protein ubiquitination plays an important role in activa

152 Protein ubiquitination plays an important role in regula

153 Protein ubiquitination plays an important role in the de

154 Protein ubiquitination plays key roles in protein turnov

155 Abeta-mediated P-gp reduction, we inhibited protein ubiquitination, protein trafficking, and the ubi

156 Protein ubiquitination provides an efficient and reversi

157 ed clusters of cellular processes, including protein ubiquitination, purine and pyrimidine metabolism

158 m avicin G treatment may be due to increased protein ubiquitination, rather than inhibition of 26S pr

159 Protein phosphorylation and protein ubiquitination regulate most aspects of cell lif

160 Protein ubiquitination regulates important innate immune

161 Protein ubiquitination regulates key cellular functions,

162 Protein ubiquitination regulates many cellular processes

163 Protein ubiquitination regulates many cellular processes

164 Protein ubiquitination regulates numerous cellular funct

165 of CUL4A and DDB1 markedly enhances RASSF1A protein ubiquitination resulting in reduced RASSF1A leve

166 Consistent with a role in protein ubiquitination, Rhp23 binds ubiquitin, as determ

167 ex implicated primarily in the regulation of protein ubiquitination, supporting a direct biochemical

168 eolytic and non-proteolytic functions of the protein ubiquitination system and describe how it is inv

169 ur results define a regulatory mechanism for protein ubiquitination that involves the signal-induced

170 ife of newly synthesised proteins, and total protein ubiquitination, thus providing a possible explan

171 Additionally, we identified protein ubiquitination to be associated among East-Asian

172 tential binary switch function for TOPORS in protein ubiquitination versus sumoylation.

173 A similar general decrease in protein ubiquitination was observed in nonneuronal cells

174 Conversely, when protein ubiquitination was prevented, or when purified p

175 uscle was accompanied by a sharp increase in protein ubiquitination, which could be blocked by argini

176 ive mechanism for suppression of transporter protein ubiquitination, which in turn decreases proteaso

177 abeled internal lysine residue indicative of protein ubiquitination, with peptides and ubiquitination