ライフサイエンスコーパス: proteinase

1 d by Virgibacillus halodenitrificans SK1-3-7 proteinase.

2 stants when it is a zymogen in comparison to proteinase.

3 reby enforcing zymogen-like character in the proteinase.

4 ece to enforce zymogen-like character in the proteinase.

5 ed receptor activated by trypsin-like serine proteinases.

6 rendering it unable to interact with target proteinases.

7 stallites is assisted by enamel proteins and proteinases.

8 n this study can be readily applied to other proteinases.

9 protein-coupled receptor activated by serine proteinases.

10 ns are well-known inhibitors of C1A cysteine proteinases.

11 antibodies to myeloperoxidase (anti-MPO) or proteinase 3 (anti-PR3) was recorded when available.

12 Neutrophil serine proteases, proteinase 3 (PR3) and human neutrophil elastase (HNE),

13 Proteinase 3 (PR3) and myeloperoxidase (MPO) are two maj

14 Proteinase 3 (PR3) is a myeloid serine protease expresse

15 GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxidase (MPO).

16 gnant cells in advanced prostate cancer, and proteinase 3 (PR3), a serine protease present in inflamm

17 Proteinase 3 (PR3), the autoantigen in granulomatosis wi

18 3 activation was mediated by serine protease proteinase 3 (PR3), which is present in the cytosol of a

19 A-associated vasculitis, positive for either proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA, w

20 oplasmic antibodies (ANCAs) directed against proteinase 3 (PR3).

21 autoantigen genes myeloperoxidase (MPO) and proteinase 3 (PRTN3) in leukocytes of patients with ANCA

22 hepsin G (CG), neutrophil elastase (NE), and proteinase 3 cleaved C5aR to a 26- to 27-kDa membrane-bo

23 r caspase alone or of elastase or neutrophil proteinase 3 failed to prevent inflammatory disease.

24 ADAM8, neutrophil elastase, cathepsin G, and proteinase 3 from contributing to circulating sIL-6R.

25 hereas neutrophil elastase, cathepsin G, and proteinase 3 have been known as granule-associated serin

26 llateral involvement of cathepsin G, NE, and proteinase 3 in cigarette smoke-induced tissue damage an

27 cific regulators of the immune response, and proteinase 3 is a major target antigen in antineutrophil

28 P = 0.027) lower ratios of baseline 12-month proteinase 3 titers than patients who did not have CYP.

29 ir response to inflammatory cytokines and to proteinase 3, a major autoantigen in GPA, and analyzed t

30 proteases (NSPs): neutrophil elastase (NE), proteinase 3, and cathepsin G.

31 hil serine proteases (NSPs), cathepsin G and proteinase 3, coexist with NE in humans and mice, but th

32 serine proteases, elastase, cathepsin G, and proteinase 3, were absent.

33 Proteinase 3-stimulated renal and lung MECs triggered CD

34 arget antigens are myeloperoxidase (MPO) and proteinase 3.

35 antineutrophil cytoplasmic antibody antigen proteinase 3.

36 luding human leukocyte elastase (p < 0.001), proteinase-3 (p < 0.01), and myeloperoxidase (p < 0.001)

37 on, we examined the role of ADAM17 in active proteinase-3 (PR3)-positive ANCA-associated vasculitis (

38 during diabetic ketoacidosis, and selective proteinase-3 antagonists may offer future vascular- and

39 cell monolayers was increased by recombinant proteinase-3 application (p = 0.010).

40 Recombinant proteinase-3 applied to human brain microvascular endoth

41 eport here that both neutrophil elastase and proteinase-3 cleave the human PAR1 N terminus at sites d

42 eutrophil azurophilic enzymes examined, only proteinase-3 correlated with diabetic ketoacidosis sever

43 ocyte origin of human leukocyte elastase and proteinase-3 in diabetic ketoacidosis was confirmed with

44 the three azurophilic enzymes elevated, only proteinase-3 levels correlated with diabetic ketoacidosi

45 Proteinase-3 might mediate vasogenic edema during diabet

46 Circulating elastase and proteinase-3 were associated with infection, and serum e

47 trophil gelatinase-associated lipocalin, and proteinase-3) were elevated in the blood of patients wit

48 neutrophil proteases including elastase and proteinase-3, generating the 33-kDa isoform that is larg

49 irus infection, AUF1 is cleaved by the viral proteinase 3CD and that AUF1 can interact with the long

50 It has been shown that the viral proteinase 3CD cleaves PCBP2 and contributes to viral tr

51 gh proteolytic cleavage of AUF1 by the viral proteinase 3CD.

52 rmation of vasculature, we hypothesized that proteinase-activated receptor (Par)-2 (official name F2r

53 e use genetic epistasis analysis to identify proteinase-activated receptor (PAR)-2-dependent inflamma

54 cardiomyocytes, and cardiac fibroblasts via proteinase-activated receptor 1 (PAR-1) and mammalian ta

55 f the major high-affinity thrombin receptor, proteinase-activated receptor 1 (PAR-1), during the deve

56 er integrity following the activation of the proteinase-activated receptor 1 (PAR1) by thrombin.

57 cantly increased, together with those of the proteinase-activated receptor 1 (PAR1), an inflammation-

58 The high-affinity thrombin receptor, proteinase-activated receptor 1 (PAR1), has been implica

59 Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signalin

60 Proteinase-activated receptor 2 (PAR2 ) is a G protein-c

61 ulation signaling via tissue factor (TF) and proteinase-activated receptor 2 (PAR2) in obesity-mediat

62 Proteinase-activated receptor 2 (PAR2) is a G protein-co

63 ta), serine proteinases such as trypsin, and proteinase-activated receptor 2 (PAR2) promote tumor dev

64 1 (TRPA1)-deficient mice but not in c-kit or proteinase-activated receptor 2 mice.

65 ucts), which likely led to the initiation of proteinase-activated receptor 2-mediated pruritus and My

66 aggregation induced by low concentrations of proteinase-activated receptor 4-activating peptide, U466

67 Proteinase-Activated Receptor-2 (PAR2 ) is a G protein-c

68 Proteinase-activated receptor-2 (PAR2), a G protein-coup

69 inases can signal by cleaving and activating proteinase-activated receptor-2 (PAR2), a G-protein-coup

70 of the following key proinflammatory genes: proteinase-activated receptor-2 (PAR2), tumor necrosis f

71 ed 5,6-EET via a mechanism that involved the proteinase-activated receptor-2 and cytochrome epoxygena

72 trated markedly reduced capacity to activate proteinase-activated receptor-2.

73 ning GTPase activating protein 2) and F2rl2 (proteinase-activated receptor-3), 2 genes that were also

74 A role for proteinase-activated receptor-4 (PAR-4) was recently sug

75 telet aggregation by coordinately activating proteinase-activated receptors (PARs) 1 and 4.

76 nicity and airway inflammation by activating proteinase-activated receptors (PARs).

77 or disarming signal transduction mediated by proteinase-activated receptors (PARs).

78 ing/activating a G-protein-coupled family of proteinase-activated receptors (PARs).

79 ultures showing a reduction in extracellular proteinase activity as demonstrated by the reduction, or

80 o discovery pipeline with highly multiplexed proteinase activity assays.

81 study revealed that the preservatives reduce proteinase activity by 50% (EC50) at a much lower concen

82 Serine proteinase activity in liquid cultures was reduced in 83

83 We show evidence of increased neutrophil proteinase activity in older adults, namely, raised leve

84 The proteinase activity was analysed with a bioluminescent m

85 stinct from those of prostasin, lack general proteinase activity, and unlike prostasins resist antipr

86 se bone morphogenetic protein-1/tolloid-like proteinase activity, in a substrate-specific manner.

87 Each of the three serine proteinase activity-based probe-labelled enzymes isolate

88 (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADA

89 nd that expression of human rhinovirus 16 2A proteinase alone can cause efficient cytoplasmic relocal

90 adenosine-5'-phosphosulfate-kinase, cysteine proteinase and eIF(4G), thus confirming the involvement

91 am was prepared using Virgibacillus sp. SK33 proteinase and fractionated using sequential ultrafiltra

92 efore, we undertook a detailed study of this proteinase and its expression.

93 Rapamycin inhibits proteinase and selected peptidase activities of the cata

94 vity toward PAPP-A2, but not selected serine proteinases and metalloproteinases.

95 psin S is one of the most important cysteine proteinases and plays key roles in nematodes and many ot

96 Proteinases and the innate immune receptor Toll-like rec

97 ted activities by inactivating their cognate proteinases, and are involved in multiple physiological

98 H prepared from V. halodenitrificans SK1-3-7 proteinase are potential functional food ingredients wit

99 factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogen

100 New opportunities exist to exploit proteinases as therapeutic targets in plaque rupture.

101 m of the central, structural pilins involves proteinase-assisted removal of their N-terminal beta str

102 Late in an adenovirus infection, the viral proteinase (AVP) becomes activated to process virion pre

103 uring assembly, activation of the adenovirus proteinase (AVP) during maturation and endosome escape f

104 Recently, mutations in the gene for the proteinase bone morphogenetic 1 (BMP1) were reported in

105 leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is trigg

106 rates a new biochemical mechanism by which a proteinase can locate its substrates, represents a new p

107 During renal injury, kidney-localized proteinases can signal by cleaving and activating protei

108 and IL-18 through activation of the cysteine proteinase caspase-1.

109 Several serine proteinases clearly influence vascular remodelling and a

110 These outcomes were induced by proteinase cleavage of the clotting protein fibrinogen,

111 G3BP1, which differs from the poliovirus 3C proteinase cleavage site previously identified.

112 We previously showed that poliovirus 3C proteinase cleaves the SG-nucleating protein G3BP1, bloc

113 roteolysis by the AAA+ protease casein lytic proteinase (Clp) XP.

114 in receptor-related protein 1 (LRP1) in both proteinase-complexed and uncomplexed forms.

115 pia mince hydrolyzed by V. halodenitrificans proteinases contained ACE inhibitory peptides that are p

116 Enhanced binding to zymogen versus proteinase correlates with the ability of the propiece t

117 the activity of MMP-25, suggesting that this proteinase could be a potential therapeutic target for i

118 indicate that current paradigms relevant to proteinase-dependent morphogenesis need be revisited, bu

119 Both proteins were sensitive to proteinase digestion.

120 tself subject to regulation by procollagen C-proteinase enhancer proteins (PCPEs) which can dramatica

121 P-9 expression, suggesting that the observed proteinase expression was regulated by the synthesis of

122 s represent a novel mechanism whereby serine proteinases facilitate epithelial cell survival and may

123 n that irreversibly inactivates the clotting proteinases factor Xa and thrombin by forming covalent c

124 d by Virgibacillus halodenitrificans SK1-3-7 proteinases for up to 24h.

125 We have identified three different serine proteinases from the German cockroach that may, via PAR2

126 Recognition of the strategic importance of proteinase function should inspire more work harnessing

127 les in regulating prothrombin activation and proteinase function.

128 Aspartic proteinases, which include HIV-1 proteinase, function with two aspartate carboxy groups a

129 hrills of discovery as we uncovered specific proteinase genes and defined specialized activities in d

130 ed under osmotic stress, along with the ClpP proteinase genes.

131 The helper component proteinase (HCPro) is an indispensable, multifunctional

132 al RNA silencing suppressor helper-component proteinase (HCpro), presumably in association with virus

133 MC/B mediators or receptors, such as serine proteinases, histamine 4-receptor, 5-lipoxygenase-activa

134 Following expression of poliovirus 2A proteinase in HeLa cells, we detect cleavage of specific

135 the region of AT that makes contact with the proteinase in the final acyl-enzyme complex.

136 depth analyses of in vivo roles of BMP1-like proteinases in bone and other tissues, and for their rol

137 y, isolate and characterize the trypsin-like proteinases in German cockroach allergen extracts used f

138 WSSV probably inhibits the activity of some proteinases in the proPO cascade.

139 Increasing evidence implicates serine proteinases in the proteolytic cascades leading to the p

140 ases (MMPs), particularly macrophage-derived proteinases, in COPD pathogenesis.

141 he conformational rearrangement required for proteinase inactivation, increase the risk of venous thr

142 The efficacy of alpha1 proteinase inhibitor (A1PI) augmentation treatment for a

143 Purified alpha1 proteinase inhibitor (A1PI) slowed emphysema progression

144 mpaired catalysis and inactivation by alpha1-proteinase inhibitor (alpha1-antitrypsin).

145 itors I and II were identified to be alpha-1-proteinase inhibitor (alpha1-PI) based on LC-MS/MS.

146 8-OHdG) and human neutrophil elastase/alpha1-proteinase inhibitor (HNE/alpha1-PI) complex have been r

147 evels of kallistatin, a member of the serine proteinase inhibitor (SERPIN) superfamily with antiangio

148 lic Acid Insensitive (SlGAI) and Cathepsin D Proteinase Inhibitor (SlPI) differed significantly in th

149 of the substrate-like Schistocerca gregaria proteinase inhibitor 2 (SGPI-2) to select reversible hig

150 The proteinase inhibitor activity and expression of JA-relat

151 Here, we report the proteinase inhibitor activity of NaStEP.

152 Our work identifies STC2 as a novel proteinase inhibitor and a previously unrecognized extra

153 pression of a biosafe, anti-feedant cysteine proteinase inhibitor and an anti-root invasion, non-leth

154 titors, T. forsythia possesses a serpin-type proteinase inhibitor called miropin.

155 samples was impaired using a broad-spectrum proteinase inhibitor cocktail, but not the pan-specific

156 pressed multifunctional member of the serine proteinase inhibitor family.

157 Purification of proteinase inhibitor from common carp (Cyprinus carpio)

158 The sugar beet serine proteinase inhibitor may be more effective for insect co

159 or clear zone that corresponded to the BvSTI proteinase inhibitor that was not detected in the untran

160 This enabled us to construct an alpha1-proteinase inhibitor variant (Ile-Lys-Pro-Arg-/-Ser-Ile-

161 covalent complexation between PR3 and alpha1-proteinase inhibitor was delayed in the presence of MCPR

162 Serine proteinase inhibitor, clade E, member 2 (SERPINE2), is a

163 Our data are the first to identify STC1 as a proteinase inhibitor, suggesting a previously unrecogniz

164 e volatile (E)-alpha-bergamotene and trypsin proteinase inhibitors (TPIs), which are also found in he

165 These include proteinase inhibitors and biosynthetic enzymes for produ

166 ng the exposure of the insects to sugar beet proteinase inhibitors and build up of non-sensitive midg

167 ent in the ECB saliva induce defense-related proteinase inhibitors in both tomato (PIN2) and maize (M

168 Proteinase inhibitors provide a means of engineering pla

169 spermiogenesis (metalloproteinase and serine proteinase inhibitors), and steroidogenesis (CYP21A2 and

170 njunction with an up-regulation of genes for proteinase inhibitors, in particular those containing th

171 reconfigurations to produce toxic compounds, proteinase inhibitors, oxidative enzymes, and behavior-m

172 We therefore conclude that the STCs are proteinase inhibitors, probably restricted in specificit

173 Coincidentally, proteinases inside the endosome cleave the EGF and insul

174 Recently, we showed the adenovirus proteinase interacts productively with its protein subst

175 with thrombospondin motifs-4) is a secreted proteinase involved in inflammation and matrix degradati

176 the cleavage of PCBP2 by the poliovirus 3CD proteinase is a necessary step for efficient viral RNA r

177 Virgibacillus sp. SK37 proteinase is a potential processing-aid for the product

178 Although neither proteinase is required for branching morphogenesis, tran

179 We show that expression of poliovirus 2A proteinase is sufficient to cause the nucleocytoplasmic

180 tion with receptors, and cleavage by tolloid proteinases is thought to relieve this inhibition.

181 ndopeptidase (AEP), a pH-controlled cysteine proteinase, is activated during ageing and mediates APP

182 ne endopeptidase (AEP), a lysosomal cysteine proteinase, is activated during aging and proteolyticall

183 ed receptor activated by trypsin-like serine proteinases, is expressed on intestinal epithelial cells

184 by bone morphogenetic protein-1/tolloid-like proteinases, is itself subject to regulation by procolla

185 Two types of proteinase K (PK)-resistant and self-perpetuating recomb

186 This was true for samples containing both proteinase K (PK)-sensitive and PK-resistant PrP(Sc) and

187 Most importantly, a putative proteinase K (PK)-sensitive form of PrP(Sc) (sPrP(Sc)) i

188 selectively cleaved by the serine protease, proteinase K (PK).

189 ion, 'cracking', second fixation, (optional) Proteinase K (Pro-K) or sonication treatment, antibody s

190 Data obtained using proteinase K accessibility, TX-114 phase partitioning, a

191 pore linker of hERG is the target domain for proteinase K cleavage.

192 In the absence of cholesterol, trypsin or proteinase K cleaved cytosolic loop 4, generating a prot

193 duced by DeltapgfS was highly susceptible to proteinase K degradation, in contrast to the high-molecu

194 Synaptic and fine granular proteinase K digestion (PrPres) immunoreactivity is foun

195 and Hyper) were subjected to dgPMCAb, their proteinase K digestion profile underwent a dramatic tran

196 Proteinase K digestion revealed conformational differenc

197 Limited proteinase K digestion revealed strain-specific PrP(Sc)

198 Spx1 was resistant to limited proteinase K digestion, but was unrelated to the express

199 TM domain to assess membrane insertion using proteinase K digestion.

200 f the alpha-synuclein fibrils was studied by proteinase K digestion.

201 ctive ingredients, we devised a method using proteinase K followed by heating to deactivate proteins

202 s for improved DNA recovery as compared with proteinase K for forensic, biochemical research, genetic

203 nsing platform to detect the presence of the proteinase K in human wound fluid, highlighting the pote

204 In contrast, the addition of proteinase K inhibited biofilm formation in all strains

205 The proteinase K LFH <3 kDa and a previously characterized p

206 rting enzyme (ACE)-inhibitory activity, only proteinase K LFH <3 kDa exerted an in vivo antihypertens

207 ting the need for the cumbersome spheroplast-proteinase K method for topology determinations.

208 Our data suggest that relative proteinase K resistance does not significantly influence

209 human brain display a distinct intermediate proteinase K resistance, suggesting the detection of a c

210 of hyperphosphorylated and abnormally folded proteinase K resistant tau.

211 of phosphorylated alpha-synuclein that were proteinase K sensitive, detergent insoluble, and formic

212 Proteinase K studies demonstrate that BbHtrA is surface

213 background uninfected PBMC counts increased; proteinase K treatment demonstrated some benefit in rest

214 ferred motility upon a pagM null mutant, and proteinase K treatment eliminated motility.

215 a disappeared in parallel with SpoVAD during proteinase K treatment of germinated spores.

216 fugation, size-exclusion chromatography, and proteinase K treatment of plant extracts suggest this RN

217 as a soluble complex that was insensitive to proteinase K treatment, consistent with MIR2911 being st

218 Upon incubation with proteinase K, a conspicuous blue shift of the EOT is obs

219 developed as a biosensing platform to detect proteinase K, an enzyme which is a readily available mod

220 were accompanied by an altered resistance to Proteinase K, higher sedimentation velocities in gradien

221 d showed resistance to low concentrations of proteinase K, it was not overtly detrimental to the flie

222 signal, extracts were treated with RNase A, Proteinase K, or heat.

223 Treatment of target cells with proteases (proteinase K, papain, alpha-chymotrypsin, and trypsin) a

224 to proteolytic digestion in vitro by either Proteinase K, pepsin or pancreatin.

225 The microaggregate species were resistant to proteinase K, phosphorylated at serine-129, oxidized, an

226 was largely accessible to exogenously added proteinase K, suggesting that this protease can access t

227 gents to permeabilize the tissue rather than proteinase K, which can damage the antigens.

228 Secreted into the plasma by the liver, the proteinase K-like serine protease PCSK9 binds the low-de

229 the plasma membrane upon reculture following proteinase K-mediated clearance of cell-surface proteins

230 ns of clinically sick mice accumulate longer proteinase K-resistant (PrP(res)) fragments of approxima

231 In addition, larger proteinase K-resistant aggregates developed, along with

232 hat NPT100-18A decreased the accumulation of proteinase K-resistant alpha-synuclein aggregates in the

233 triatum led to decrease in the levels of the proteinase K-resistant fraction of alpha-synuclein, amel

234 es, a form characterized by short C-terminal proteinase K-resistant fragments, in a prion strain of s

235 ce again resulted in significantly augmented proteinase K-resistant prion protein deposition and acce

236 f PrP(C), leading to increased generation of proteinase K-resistant prion protein.

237 However, detailed analysis revealed that the proteinase K-resistant profile of PrP(Sc) changed in res

238 the hallmark features of CJD, spongiosis and proteinase K-resistant PrP aggregates, initially develop

239 spongiform encephalopathy, and formation of proteinase K-resistant PrP(TSE).

240 induced conversion of PrP(C) to the abnormal proteinase K-resistant state, referred to as atypical Pr

241 gregated alpha-synuclein within Lewy bodies (proteinase K-resistant).

242 t extracts suggest this RNA resides within a proteinase K-sensitive complex.

243 Here we show a linear increase of proteinase K-sensitive PrP isoforms distinct from classi

244 physiological, presynaptic alpha-synuclein (proteinase K-sensitive) and highly aggregated alpha-synu

245 In contrast, proteinase K-treated AD homogenates and Sarkosyl-soluble

246 ubstrates and/or immunoblot band profiles of proteinase K-treated RT-QuIC reaction products indicated

247 degradation even in the presence of protease proteinase K.

248 bit excellent proteolytic resistance against proteinase K.

249 lysis when intact bacteria were treated with proteinase K.

250 ophores by means of enzymatic digestion with proteinase K.

251 capsulation mitigated enzyme inactivation by proteinase K.

252 ophobic and more resistant to proteolysis by proteinase K.

253 erminal tail from proteolytic degradation by proteinase K.

254 Progressive aggregation of proteinase-K resistant and Ser129-phosphorylated alpha-s

255 ecombinant PrP amyloid fibrils with extended proteinase-K resistant beta-sheet cores and infrared spe

256 d4 as a result of decreased MMP2, a secreted proteinase key for brain tumor invasion.

257 through the deregulation of kallikrein-like proteinase (KLK) family members.

258 viral proteins, one of them being the leader proteinase L.

259 trix metalloproteinase 3, a matrix-degrading proteinase linked to pulmonary fibrosis.

260 BMP1 and the closely related proteinase mammalian tolloid-like 1 (mTLL1) are co-expre

261 OA cartilage such that we hypothesized this proteinase may also contribute to matrix turnover.

262 valent complex between the inhibitor and the proteinase, mediated by Cys-120 of STC2.

263 ed expression of PD-L1 and of matrix metallo-proteinases (MMPs) and CD-10 in those cells.

264 ng the nucleating factor G3BP1 via the viral proteinase NS6(Pro) This work provides new insights into

265 BP1), which is mediated by the viral 3C-like proteinase NS6(Pro) Using mutational analysis, we identi

266 olysin with karilysin, as well as a cysteine proteinase of another periodontal pathogen, Prevotella i

267 hydrolysis with a non-commercially available proteinase of fig-leaf gourd fruit (Cucurbita ficifolia)

268 The secreted aspartyl proteinases of Candida albicans have long been implicate

269 represents a prime target for 3C or 3C-like proteinases of different viruses.

270 d that NEMO is also cleaved by 3C or 3C-like proteinases of picornavirus and artertivirus.

271 t characteristic of emphysema, extracellular proteinases, particularly those with elastolytic ability

272 However, the roles that these proteinases play during mammary gland development in viv

273 A Ficus carica L. latex proteinase preparation was investigated for its ability

274 es showed a 57%-71% sequence identity with a proteinase previously cloned from the American cockroach

275 is a readily available model system for the proteinase produced by Pseudomonas aeruginosa.

276 heighten inflammation as a result of excess proteinase release during inaccurate chemotaxis, as well

277 Neutrophil proteinases released at sites of inflammation can affect

278 teinases (MMPs) are a family of host-derived proteinases reported to mediate multiple functions assoc

279 endent conformations of PrP(Sc), we purified proteinase-resistant PrP(Sc) (PrP(RES)) from mouse brain

280 subunit of fimbriae and an arginine-specific proteinase, respectively, was downregulated in the pgn_1

281 -type 6 (MT6) MMP (also known as MMP25) as a proteinase responsible for CD16 downmodulation.

282 rances, mating competency, secreted aspartyl proteinase (Sap) activities, and virulence.

283 The A. bisporus serine proteinase SPR1 is induced by humic acids and is highly

284 proteaseStreptococcus pyogenescell envelope proteinase (SpyCEP), thus blunting neutrophil-mediated k

285 adults, namely, raised levels of neutrophil proteinase substrate-derived peptides and evidence of pr

286 dentification of metalloproteinase and other proteinase substrates and their respective cleavage site

287 The propeptides of subtilisin-like serine proteinases (subtilases, SBTs) serve dual functions as i

288 orming growth factor-beta (TGF-beta), serine proteinases such as trypsin, and proteinase-activated re

289 We devised an approach for proteinase target identification that combines an in sil

290 tance1 (mir1) gene product, a cysteine (Cys) proteinase that is a key defensive protein against chewi

291 type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-type plasm

292 type plasminogen activator (uPA) is a serine proteinase that, upon binding to its receptor (uPAR), ca

293 like elastases (CELAs) are pancreatic serine proteinases that digest dietary proteins.

294 An activated adenovirus proteinase, the AVP-pVIc complex, was shown to slide alo

295 r the past 5 years in relating extracellular proteinases to plaque rupture, the cause of most myocard

296 We conclude that neutrophil proteinases trigger biased PAR1 signaling and we describ

297 trated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel initiator o

298 an meal hydrolysed by Virgibacillus sp. SK37 proteinases (VH), Alcalase (AH) and Neutrase (NH) were i

299 ccal CXC protease, S. pyogenes cell envelope proteinase, we developed a combination vaccine that is h

300 Aspartic proteinases, which include HIV-1 proteinase, function wi