ライフサイエンスコーパス: proteinase-activated receptor

1 generation of plasmin, it was independent of proteinase-activated receptor 1 (PAR-1) and instead refl

2 cardiomyocytes, and cardiac fibroblasts via proteinase-activated receptor 1 (PAR-1) and mammalian ta

3 f the major high-affinity thrombin receptor, proteinase-activated receptor 1 (PAR-1), during the deve

4 er integrity following the activation of the proteinase-activated receptor 1 (PAR1) by thrombin.

5 cantly increased, together with those of the proteinase-activated receptor 1 (PAR1), an inflammation-

6 The high-affinity thrombin receptor, proteinase-activated receptor 1 (PAR1), has been implica

7 Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signalin

8 riginating in the G-protein-coupled receptor proteinase-activated receptor 1 (PAR1).

9 Proteinase-activated-receptor 1 (PAR-1) and epidermal gr

10 As thrombin binding to the G protein-coupled proteinase activated receptor-1 (PAR-1) induces endothel

11 he mechanisms of restoration of cell surface proteinase-activated receptor-1 (PAR-1) by investigating

12 Proteinase-activated receptor-1 (PAR-1) is protective ag

13 ility by the activation of G protein-coupled proteinase-activated receptor-1 (PAR-1).

14 the NH(2) terminus of the G protein-coupled proteinase-activated receptor-1 (PAR-1).

15 o transactivation of EGF receptor (EGFR) via proteinase-activated receptor 2 (PAR(2)) activation.

16 Proteinase-activated receptor 2 (PAR-2) is a recently ch

17 The proteinase-activated receptor 2 (PAR-2) is important for

18 al sequencing, while its ability to activate proteinase-activated receptor 2 (PAR-2) was determined u

19 ses activate the G protein-coupled receptor, proteinase-activated receptor 2 (PAR-2), via cleavage an

20 Proteinase-activated receptor 2 (PAR2 ) is a G protein-c

21 NB thymosin beta (TMSNB) and proteinase-activated receptor 2 (PAR2) (both downregulat

22 Thrombin receptor and proteinase-activated receptor 2 (PAR2) define a family o

23 ulation signaling via tissue factor (TF) and proteinase-activated receptor 2 (PAR2) in obesity-mediat

24 Proteinase-activated receptor 2 (PAR2) is a G protein-co

25 Proteinase-activated receptor 2 (PAR2) is a receptor for

26 ta), serine proteinases such as trypsin, and proteinase-activated receptor 2 (PAR2) promote tumor dev

27 We report that agonists of Galphaq-coupled proteinase-activated receptor 2 (PAR2) stimulate formati

28 Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 (PAR2) to induce alterat

29 Proteinase-activated receptor 2 (PAR2), a seven-transmem

30 fibers of the respiratory tract by cleaving proteinase-activated receptor 2 (PAR2).

31 We then demonstrated that injection of the proteinase-activated receptor 2 activating peptide into

32 Using a specific proteinase-activated receptor 2 activating peptide, we f

33 to noxious stimulation of the pancreas with proteinase-activated receptor 2 agonists.

34 ents after intrapancreatic administration of proteinase-activated receptor 2 agonists.

35 ctions was performed with antibodies against proteinase-activated receptor 2 and vanilloid receptor 1

36 Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown mechanis

37 These observations suggest that proteinase-activated receptor 2 contributes to nocicepti

38 gnals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal reg

39 The proteinase-activated receptor 2 is expressed on a subset

40 Thus, tryptase inhibitors and antagonists of proteinase-activated receptor 2 may be useful anti-infla

41 1 (TRPA1)-deficient mice but not in c-kit or proteinase-activated receptor 2 mice.

42 Proteinase-activated receptor 2 was expressed by virtual

43 imary spinal afferent neurons, which express proteinase-activated receptor 2, also contain the proinf

44 ucts), which likely led to the initiation of proteinase-activated receptor 2-mediated pruritus and My

45 Our findings suggest a novel proteinase-activated receptor 2-mediated role for trypsi

46 Preinfusion of the pancreatic duct with proteinase-activated receptor 2-specific activating pept

47 Both trypsin and a proteinase-activated receptor 2-specific peptide agonist

48 an also activate nociceptive neurons via the proteinase-activated receptor 2.

49 te inflammatory edema induced by agonists of proteinase-activated receptor 2.

50 orthern blot analysis completed with a human proteinase activated receptor-2 (PAR-2) cDNA as probe de

51 rk shows that the G-protein-coupled receptor proteinase activated receptor-2 activates signals that s

52 emarkably similar to the organization of the proteinase activated receptor-2 gene in which the putati

53 cally cleaved receptors that may include the proteinase activated receptor-2.

54 We hypothesized that proteinase-activated receptor-2 (PAR(2)) modulates intes

55 Proteinase-Activated receptor-2 (PAR(2)), a G-protein-co

56 Proteinase-activated receptor-2 (PAR-2) is a G protein-c

57 Proteinase-activated receptor-2 (PAR-2) is a G protein-c

58 Proteinase-activated receptor-2 (PAR-2) is a G-protein-c

59 The proteinase-activated receptor-2 (PAR-2) is the second me

60 Proteinase-activated receptor-2 (PAR-2) may participate

61 e disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal

62 synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2), which is consis

63 Proteinase-Activated Receptor-2 (PAR2 ) is a G protein-c

64 Proteinase-activated receptor-2 (PAR2), a G protein-coup

65 inases can signal by cleaving and activating proteinase-activated receptor-2 (PAR2), a G-protein-coup

66 of the following key proinflammatory genes: proteinase-activated receptor-2 (PAR2), tumor necrosis f

67 ctivated receptor-2, either through specific proteinase-activated receptor-2 activating peptides or t

68 contrast, Rho activity did not affect either proteinase-activated receptor-2 activity or mRNA and pro

69 ed 5,6-EET via a mechanism that involved the proteinase-activated receptor-2 and cytochrome epoxygena

70 New insights into the role of proteinase-activated receptor-2 in the pancreas add to t

71 We show that proteinase-activated receptor-2 mediated phagocytosis in

72 These data are the first to show that proteinase-activated receptor-2 mediated phagocytosis is

73 Proteinase-activated receptor-2 mediated Rho activation

74 We explored the signaling mechanisms of proteinase-activated receptor-2 mediated Rho activation

75 uman keratinocytes is Rho dependent and that proteinase-activated receptor-2 signals to activate Rho.

76 iated phagocytosis is Rho dependent and that proteinase-activated receptor-2 signals to Rho and cAMP

77 an keratinocytes and show that activation of proteinase-activated receptor-2, either through specific

78 trated markedly reduced capacity to activate proteinase-activated receptor-2.

79 ning GTPase activating protein 2) and F2rl2 (proteinase-activated receptor-3), 2 genes that were also

80 aggregation induced by low concentrations of proteinase-activated receptor 4-activating peptide, U466

81 Proteinase-activated receptors 4 (PAR(4)) is a class A G

82 A role for proteinase-activated receptor-4 (PAR-4) was recently sug

83 cornea are activation of thrombin-sensitive, proteinase-activated receptors and cleavage of fibrinoge

84 Proteinase-activated receptors and peroxisome proliferat

85 Proteinase-activated receptors are a family of seven-tra

86 reviously known to regulate inflammation via proteinase-activated receptors, can also play a substant

87 Binding and barrier assays in proteinase activated receptor (PAR)(2)-expressing and PA

88 These targets include proteinase-activated receptor (PAR) 1 or histamine recep

89 Proteases and proteinase-activated receptor (PAR) activation are invol

90 diseases, is the increased expression of the proteinase-activated receptor (PAR) subtype PAR-2.

91 to examine whether HCECs express functional proteinase-activated receptor (PAR)-1 and -2 and evaluat

92 rmation of vasculature, we hypothesized that proteinase-activated receptor (Par)-2 (official name F2r

93 e use genetic epistasis analysis to identify proteinase-activated receptor (PAR)-2-dependent inflamma

94 ochemistry, we confirmed renal expression of proteinase-activated receptor (PAR-2) and demonstrated i

95 A second proteinase-activated receptor (PAR-2) was cloned recentl

96 A proteinase-activated receptor (PAR-2)-specific agonist p

97 telet aggregation by coordinately activating proteinase-activated receptors (PARs) 1 and 4.

98 Proteinase-activated receptors (PARs) are novel G-protei

99 Proteases cleave proteinase-activated receptors (PARs) to expose N-termin

100 or disarming signal transduction mediated by proteinase-activated receptors (PARs).

101 nicity and airway inflammation by activating proteinase-activated receptors (PARs).

102 ing/activating a G-protein-coupled family of proteinase-activated receptors (PARs).

103 Proteases regulate cells by cleaving proteinase-activated receptors (PARs).

104 ding prostaglandin subtypes, growth factors, proteinase-activated receptors, peroxisome proliferator-