ライフサイエンスコーパス: proteolysis

1 sensitivity and alters calpain-mediated cTnI proteolysis.

2 tive complex and hence the likelihood of Gag proteolysis.

3 erlinC72, which is particularly resistant to proteolysis.

4 to reporter expression through site-specific proteolysis.

5 asmic proteins through ubiquitin-independent proteolysis.

6 hia coli followed by oxidative refolding and proteolysis.

7 ctions with the extracellular matrix and for proteolysis.

8 y pathway rather than through 26S proteasome proteolysis.

9 geting PDK4 content through dissociation and proteolysis.

10 heat and were highly resistant to intestinal proteolysis.

11 itotic processes through ubiquitin-dependent proteolysis.

12 very of substrates to the 26S proteasome for proteolysis.

13 fusion may slow down the proteasome-mediated proteolysis.

14 nitrosation (by measuring nitrosamines), and proteolysis.

15 eptible to PAX4-induced enzymes that promote proteolysis.

16 % alpha-helix and are unusually resistant to proteolysis.

17 nhance the A1 domain's resistance to limited proteolysis.

18 , a negative regulator of Wnt signaling, for proteolysis.

19 o rapidly and robustly activate pericellular proteolysis.

20 transmission electron microscopy or limited proteolysis.

21 proteins whose detection required nontryptic proteolysis.

22 ich proteins are selected to be targeted for proteolysis.

23 w of the increasingly complex picture of APP proteolysis.

24 mentation of the cocoa beans by acid-induced proteolysis.

25 amers in their native state before and after proteolysis.

26 iomyocytes via protease-activated receptor 2 proteolysis.

27 ins or fibres in biscuits lowered or delayed proteolysis.

28 s and explain differential susceptibility to proteolysis.

29 ) caused by elevated basal caspase-dependent proteolysis.

30 und proteins undergo regulated intramembrane proteolysis.

31 defects caused by misregulated extracellular proteolysis.

32 conformational change in the substrate upon proteolysis.

33 s could fold, sheltered from aggregation and proteolysis.

34 minal fragment consistent with intramembrane proteolysis.

35 ins that unfold slower are more resistant to proteolysis.

36 he cleavage site has been mutated to inhibit proteolysis.

37 minal residues is important for Lon-mediated proteolysis.

38 llular processes such as DNA replication and proteolysis.

39 ads to destabilization by the RING E3 ligase PROTEOLYSIS 1 (PRT1) of the N-end rule pathway.

40 cytoskeletal mechanotransduction [5], and/or proteolysis [6], most likely under the control of transc

41 Upon proteolysis, a gradual increase in the golden color of t

42 Our findings indicate that PCSK9 proteolysis acts as a commonly perturbed but critical sw

43 Quantitative and qualitative evaluations of proteolysis after milk coagulation, determined by the no

44 Concomitant with TDP-43 aggregation and proteolysis after prolonged arsenite exposure, GADD34-bo

45 Here, through limited proteolysis analysis, we demonstrate that the evolutiona

46 that underwent the most intense response to proteolysis and adhesiveness.

47 this research is to identify biomarkers for proteolysis and adhesiveness.

48 eta-amino acid residues on susceptibility to proteolysis and agonist activity.

49 ooming phase while proteins participating in proteolysis and central carbon metabolism were abundant

50 Here we used time-resolved limited proteolysis and chemical cross-linking to examine nucleo

51 mutant neurons also show impaired lysosomal proteolysis and decreased activity of the lysosomal enzy

52 siologic effects, such as accelerated muscle proteolysis and diminished nutrient absorption, and may

53 did affect lactoferrin and alpha-lactalbumin proteolysis and emulsion disintegration.

54 ysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiq

55 the gut microbiota, reductions in microbial proteolysis and increases in microbial dietary choline p

56 ation in macrophages enhances lysosome-based proteolysis and killing of subsequently phagocytosed E.

57 It also exacerbates proteolysis and leads to muscle depletion.

58 The kinetics of proteolysis and lipolysis differed according to the phys

59 Tumors displaying active VCAN proteolysis and low total VCAN were associated with robu

60 is correlated with increased sensitivity to proteolysis and lower-resolution diffraction, particular

61 Using limited proteolysis and mass spectrometry, we found that in the

62 The restricted proteolysis and milk-clotting potential are attractive p

63 Most circulating SAA is protected from proteolysis and misfolding by binding to plasma high-den

64 Time showed positive effect on proteolysis and negatively affected angiotensin I-conver

65 Numerous studies have shown that proteolysis and oxidative stress are among the major eff

66 nt limitation by coordinately promoting LapA proteolysis and preventing de novo LapA synthesis and se

67 rovides insights into the basic mechanism of proteolysis and propeptide autolysis, as well as the evo

68 PSE was more susceptible to proteolysis and protein oxidation than normal meat durin

69 epair and glucose metabolism, down-regulated proteolysis and protein transport, and showed high level

70 ineered receptor is cleaved by intramembrane proteolysis and releases a protein fragment that regulat

71 eus, IFN-gamma treatment led to decreased L1 proteolysis and retention of L2 and the viral genome in

72 sense SNPs within PCSK9, alterations in both proteolysis and secretion are common.

73 necting coagulation initiation to epithelial proteolysis and signaling.

74 its gastrointestinal kinetics of lipolysis, proteolysis and structural disintegration.

75 Limited proteolysis and surface-topology mapping of protein G'e

76 the specific genomic sites targeted for H3NT proteolysis and the functional significance of H3NT clea

77 cking and diminished regulated intramembrane proteolysis and transcriptional activity; class 2 ATF6 m

78 milar assays with HtrA2 showed minimal ApoE4 proteolysis and trypsin had no preference between ApoE4

79 nd structural features that ensure efficient proteolysis and ubiquitin recycling while preventing non

80 In addition, lower pH values, higher proteolysis, and a decrease in toughness, elasticity and

81 specific self-recognition and resistance to proteolysis, and an extended form, which most likely all

82 ddition, via chemical cross-linking, limited proteolysis, and mass spectrometry, we identified protei

83 Intrinsic fluorescence, limited proteolysis, and molecular dynamics studies suggest the

84 Immunofluorescence assay, surface proteolysis, and novel cell fractionation schemes reveal

85 epletion in vivo renders uS11 susceptible to proteolysis, and precludes eS26 incorporation into the 9

86 -canonical caspase substrate recognition and proteolysis, and the direct roles for caspases in gene e

87 itin recycling while preventing nonselective proteolysis, and the regulation of proteasome activity b

88 d fluorogenic probes of citrulline-dependent proteolysis, and the resultant beads (1.3 million) were

89 Intracellular peptides generated by limited proteolysis are likely to function inside and outside ce

90 y for the astrotactins, reveal intramembrane proteolysis as a feature of astrotactin maturation, and

91 indings provide a rationale for testing VCAN proteolysis as a predictive and/or prognostic immune bio

92 ism, and include enzymes involved in general proteolysis as well as highly specific processing protea

93 ransferrin receptor eliminates intramembrane proteolysis, as does leucine substitution of residues th

94 ficiency in lysosomes and impaired lysosomal proteolysis, as evidenced by aberrant accumulation of se

95 o identify small peptides arising from actin proteolysis, as influenced by the type of processing.

96 e been broadly attributed to protection from proteolysis, as the extracellular milieu is an aggressiv

97 el of the soluble Abeta peptides produced by proteolysis, as well as the Abeta42/Abeta40 ratio, both

98 gand transmembrane receptor that can undergo proteolysis at the cell surface to release a soluble ect

99 are initially cleaved during gastroduodenal proteolysis at three major sites between residues 39-40,

100 (HA) of influenza virus must be activated by proteolysis before the virus can become infectious.

101 Slight changes were observed in proteolysis, bioactivity, water mobility, texture profil

102 It renders APP less susceptible to proteolysis by BACE without inhibiting BACE enzymatic ac

103 The main consequence of proteolysis by Calotropis procera extract or chymosin wa

104 t is unclear how antitoxins are selected for proteolysis by cellular proteases.

105 assumption that uncontrolled ADEP-activated proteolysis by ClpP is the common mode of killing.

106 e molecular mechanisms that regulate the RCL proteolysis by co-existing host and bacterial elastases

107 In bacteria, the adaptor ClpS mediates proteolysis by delivering substrates bearing specific N-

108 and enhancing focalized extracellular matrix proteolysis by directing the delivery and accumulation o

109 Since full-length amelogenin undergoes proteolysis by matrix metalloproteinase 20 (MMP20, ename

110 l islet cells' VTCN1 is caused by the active proteolysis by metalloproteinase N-arginine dibasic conv

111 were less hydrophobic and more resistant to proteolysis by proteinase K.

112 dence suggests that the accepted view of APP proteolysis by the canonical alpha-, beta-, and gamma-se

113 ircumvents specific genetic requirements for proteolysis causes biomineralization defects, showing th

114 To more precisely determine how sequential proteolysis contributes to CoV infection, we introduced

115 These cell type-specific requirements for proteolysis correlated with S conformations during cell

116 igh-resolution NMR spectroscopy, and limited proteolysis coupled with mass spectrometry, we show that

117 After proteolysis, CTF2 remains associated with beta-catenin,

118 conformationally sensitive epitopes supports proteolysis data.

119 ich is one of the factors that leads to ToxR proteolysis, decreased the interaction between ToxRp and

120 a potential approach for rescuing lysosomal proteolysis deficits in AD.

121 adoxically, PGC1beta represses the ubiquitin-proteolysis degradation pathway genes resulting in ubiqu

122 Limited proteolysis demonstrates that a structural core of Nanog

123 he zymogen-locked version of prostasin and a proteolysis-dependent function of activated prostasin in

124 d as a new therapeutic strategy for treating proteolysis-driven chronic inflammatory diseases, but it

125 dation before digestion resulted in impaired proteolysis during digestion.

126 Excessive proteolysis during dry-cured ham processing may lead to

127 anscription factor ATF6alpha is activated by proteolysis during endoplasmic reticulum (ER) stress.

128 us assembly and the 6-helix bundle regulates proteolysis during maturation.

129 binds an autoprocessing domain to activate a proteolysis event that releases the N-terminal glucosylt

130 In agreement with MAS NMR data, proteolysis experiments performed on the full length KpO

131 In addition, limited proteolysis experiments showed a reduced stability of L1

132 intestinal conditions), physicochemical (pH, proteolysis, fatty acids), bioactivity (antioxidant effe

133 f ubiquitin-proteasome system (UPS)-mediated proteolysis following heat stress.

134 ements, dynamic light scattering, controlled proteolysis, gel electrophoresis, site-directed mutagene

135 sages, myofibrillar proteins undergo intense proteolysis generating small peptides and free amino aci

136 inely degraded via the N-end rule pathway of proteolysis in an oxygen- and nitric oxide-dependent man

137 te in adenosine triphosphate (ATP)-dependent proteolysis in bacteria.

138 f glycosylation and protect against ADAMTS13 proteolysis in both the VWF A2 domain and FLVWF.

139 This was associated with less cTnI proteolysis in cTnIS200D hearts.

140 tyrosol induced a shift toward inhibition of proteolysis in endothelial cells, with decreased express

141 PSY in clpc1, counterbalancing Clp-mediated proteolysis in maintaining PSY protein homeostasis.

142 actatemia, insulin resistance, and increased proteolysis in mouse skeletal muscle.

143 upport the necessity of MMP-9-dependent H3NT proteolysis in regulating gene pathways required for pro

144 TCP14 proteolysis in spy-3 suppressed all TCP14 misexpression

145 e addition of co-culture influenced (p<0.01) proteolysis in the cheese and resulted in a higher conte

146 tion-dependent nuclear export and subsequent proteolysis in the cytoplasm.

147 ion of gamma-secretase and metalloproteinase proteolysis in the NOTCH pathway, or silencing of alpha2

148 ine-rich repeat protein 17) targets Sufu for proteolysis in the nucleus.

149 In addition to its role in proteolysis in the stroma, biochemical and genetic evide

150 assays, and display remarkable resistance to proteolysis, in cases remaining active after extended ex

151 trated to signal via regulated intramembrane proteolysis, in which ectodomain shedding and subsequent

152 After elution, RBPs are subjected to partial proteolysis, in which the protein regions still bound to

153 sequence specificities of PCSK9 cleavage and proteolysis-independent secretion.

154 We found that hams of higher proteolysis index had statistically significant increase

155 In addition, higher proteolysis index hams showed increased degradation for

156 increased remarkably in samples with higher proteolysis index scores.

157 physicochemical parameters, including their proteolysis indices and instrumental adhesiveness.

158 Proteins of samples with extreme proteolysis indices were separated by two-dimensional el

159 sed capacity for protein synthesis, enhanced proteolysis, inefficient energy generation and reduced c

160 ubiquitin-proteasome system-mediated muscle proteolysis, inflammation, and decreased mitochondrial c

161 nodes whereas it partially limits in vivo Ag proteolysis inside DCs.

162 Proteolysis is a major process in the biology of MHC-II,

163 Toxoplasma persistence and suggests that VAC proteolysis is a prospective target for pharmacological

164 Because ECM proteolysis is an abundant biochemical process that is c

165 Such proteolysis is carried out either by endogenous enzymes

166 It is not well understood how ligand proteolysis is controlled at the molecular level or how

167 In living cells intracellular proteolysis is crucial for protein homeostasis, and ClpP

168 Lysosomal proteolysis is essential for the quality control of intr

169 Regulated intramembrane proteolysis is initiated by shedding, and the remaining

170 Astn2 intramembrane proteolysis is insensitive to replacement of TM2 by the

171 Although proteasome-mediated proteolysis is known to produce antigenic peptides in ad

172 Curiously, whereas OGT-mediated HCF-1 proteolysis is limited to vertebrate species, invertebra

173 Enhanced N-terminal histone H3 proteolysis is observed in GDH1 mutants, consistent with

174 ast differentiation, we discovered that H3NT proteolysis is selectively targeted near transcription s

175 structural data, and suggest that PCSK9 self-proteolysis is the rate-limiting step of secretion.

176 arginyl residue of the EGF domain, and that proteolysis is the regulated and rate-limiting step in g

177 cellular proteostasis, controlled in part by proteolysis, is essential in maintaining the integrity o

178 Limited proteolysis, kinetic simulations, and MS analyses confir

179 e that impaired O-glycosylation and enhanced proteolysis lead to attenuated receptor signaling, becau

180 promoted the expression of genes related to proteolysis, lipolysis and amino acid/lipid catabolism a

181 to the postfusion conformation using limited proteolysis, mass spectrometry, and single-particle EM.

182 O-GlcNAc homeostasis and host cell factor 1 proteolysis may play roles in mediation of XLID in indiv

183 ow-derived progenitors, suggesting that VCAN proteolysis may promote differentiation of tumor-seeding

184 GST-PEX9 inhibited MMP-9-driven gelatin proteolysis, measured by gelatin zymography, FITC-gelati

185 ase toxic proteins culminating in widespread proteolysis, nucleolysis, and cell engulfment.

186 ve site, we show here that glycosylation and proteolysis occur through separable mechanisms.

187 EN-box receptor was only required for normal proteolysis of a subset of substrates and the ABBA motif

188 he D-box receptor was required for efficient proteolysis of all Cdh1 substrates, despite the absence

189 docyte injury in vitro, including diminished proteolysis of alpha-actinin-4.

190 The MMP-20 proteolysis of amelogenin was studied, and the morpholog

191 gamma-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into shor

192 One response to stress is selective proteolysis of antitoxin proteins which releases their c

193 to inhibit toxin activity and the regulated proteolysis of antitoxins.

194 but this remains to be realized due to rapid proteolysis of apelin-derived peptides by proteases, inc

195 d poly(ADP-ribosyl)ation, which promotes the proteolysis of Axin and consequent stabilization of beta

196 lates the metalloproteinase-mediated limited proteolysis of beta1AR.

197 eperfusion injury, potentially by decreasing proteolysis of cTnI.

198 Ubiquitin-dependent proteolysis of cyclin D1 is associated with normal and t

199 We show here that, by promoting proteolysis of cyclins and Cdc25B at the germinal vesicl

200 fetal dendritic cell progenitors attenuated proteolysis of endocytosed OVA for delayed presentation

201 We monitored the proteolysis of farnesylated prelamin A peptide by ZMPSTE

202 tPA) administration revealed that incomplete proteolysis of fibrin polymers markedly facilitated clot

203 can be attributed in part to MCPT4-mediated proteolysis of fibronectin.

204 t paradigm that nuclear export regulates the proteolysis of FOXO3A/4 tumour suppressors in the contex

205 utations within this site selectively impair proteolysis of full-length MKKs yet have no impact on cl

206 se, is a target for these proteases and that proteolysis of galectin-3 is a novel immune evasion mech

207 H oxidase was abrogated by bacterium-derived proteolysis of galectin-3, and SspB was identified as th

208 leading to the idea that ubiquitin-mediated proteolysis of Gcn4 is required for its activity.

209 ral different aggregating sites from limited proteolysis of harvested aggregates and effects of mutat

210 Our work suggests that proteolysis of IP3R1 may represent a novel form of modul

211 Pasteurization enhanced the proteolysis of lactoferrin (P < 0.01) and reduced that o

212 of the mutation, CBZ application stimulated proteolysis of misfolded collagen X by either autophagy

213 ation, but this can be alleviated by induced proteolysis of Mrc1 after checkpoint activation.

214 because it is both responsible for regulated proteolysis of Notch receptors and catalyzes the non-amy

215 g a framework for mechanistic studies in the proteolysis of outer membrane proteins.

216 ions of native HNPs toward ADAMTS13-mediated proteolysis of peptidyl VWF73 and multimeric VWF are 3.5

217 s NUP98-RAE1 away from APC/CCDH1, triggering proteolysis of polo-like kinase 1 (PLK1), a tumor suppre

218 Proteomics frequently requires proteolysis of proteins into peptide fragments.

219 Together, our data suggest that proteolysis of RAGE is critical to mediate signaling and

220 Limited proteolysis of RNase-A yields a short N-terminal S-pepti

221 high structural stability and resistance to proteolysis of SAA oligomers at pH 3.5-4.5 help them esc

222 ing of the Rgg2/3 pathway through a means of proteolysis of SHP peptide pheromones.

223 Limited proteolysis of spheroplasts revealed that the C-terminal

224 -GMP effector protein LapD, and resulting in proteolysis of the adhesin LapA and the subsequent relea

225 utgrowth and guidance is mediated by calpain proteolysis of the adhesion proteins talin and focal adh

226 show that ester formation can indeed lead to proteolysis of the adjacent peptide bond, thereby provid

227 Proteolysis of the amyloid precursor protein (APP) liber

228 beta), which is generated through sequential proteolysis of the amyloid precursor protein (APP), firs

229 Abeta43, a product of the proteolysis of the amyloid precursor protein APP, is rel

230 We show that limited proteolysis of the detergent-solubilized and purified ye

231 nc-containing active site, thus impeding its proteolysis of the endogenous protein substrate, synapto

232 The main focus was on catabolites formed by proteolysis of the fusion protein in rabbit following in

233 Although limited proteolysis of the histone H3 N-terminal tail (H3NT) is

234 signaling is determined by the efficiency of proteolysis of the N terminus, which is regulated by all

235 -secretase-dependent regulated intramembrane proteolysis of the p75 neurotrophin receptor (also known

236 AD mouse model were strongly associated with proteolysis of the protein phosphatase calcineurin (CN)

237 Limited proteolysis of the recombinant A6 protein identified an

238 In this article, we report that proteolysis of the tolerogenic matrix proteoglycan versi

239 -GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1.

240 Proteolysis of versican generates a hyaluronan-binding G

241 Therefore, proteolysis of VWF appears promising to disaggregate pla

242 conducted to assess the effect of amelogenin proteolysis on calcium phosphate formation.

243 rce to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tu

244 Molecular dynamics simulation showed that proteolysis only occurred in the vibrant regions of the

245 ns on the CBM have little impact on binding, proteolysis, or activity in the whole-enzyme context.

246 Collectively, our data reveal how Cad6B proteolysis orchestrates multiple pro-EMT regulatory inp

247 iotics L. acidophilus), physicochemical (pH, proteolysis, organic acids, fatty acids, and volatile pr

248 in-selective chaperone Cdc48, revealing that proteolysis per se is not required for Gcn4 activity.

249 information for a better characterisation of proteolysis phenomena during the processing of dry-cured

250 are naturally generated in foods through the proteolysis phenomena taking place during processing.

251 ation initiation, cell cycle, DNA damage and proteolysis processes that affect multiple key neural de

252 ed that gamma found in Pol III HE might be a proteolysis product of tau.

253 rNanI species corresponding to proteolysis products also promoted the cytotoxic activit

254 phase of the hair cycle, or elucidate which proteolysis products from keratinocytes promote skin inf

255 lular state, multiplexed signaling pathways, proteolysis products, and mRNA transcripts.

256 imulations of acyl-enzyme intermediates with proteolysis rates spanning 3 orders of magnitude, we ide

257 Proteolysis releases the SREBP transcription factor doma

258 owever, the mechanisms and functions of RGS2 proteolysis remain poorly understood.

259 g, the immunoregulatory consequences of VCAN proteolysis remain unknown.

260 llulose conversion via their contribution to proteolysis resistance.

261 gulating VCAN levels at the tumor site, VCAN proteolysis results in the generation of bioactive fragm

262 ition enhances productive autophagy and mHtt proteolysis, revealing a useful pharmacological point of

263 aired functioning in regulated intramembrane proteolysis (RIP) of OASIS, ATF6 and SREBP transcription

264 mphocryptovirus enables B cells to protect a proteolysis-sensitive immunodominant myelin oligodendroc

265 red, highly inhomogeneous and susceptible to proteolysis; some of them withstand the dithiothreitol t

266 shear stress, or alpha-chymotrypsin-mediated proteolysis, suggesting that PON-2 did not alter the reg

267 plex comprises the core particle (CP), where proteolysis takes place, and one or two regulatory parti

268 Here we report the development of a proteolysis targeting chimera (PROTAC) based on the comb

269 degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce

270 Proteolysis Targeting Chimera (PROTAC) technology is a r

271 a new potent SIRT2 inhibitor (MZ242) and its proteolysis targeting chimera (SH1) acting together with

272 Proteolysis targeting chimeras (PROTACs) are bifunctiona

273 Proteolysis targeting chimeras (PROTACs) are bispecific

274 Additionally, bifunctional proteolysis targeting chimeras (PROTACs) containing a VH

275 , a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demon

276 The design of proteolysis-targeting chimeras (PROTACs) is a powerful s

277 ng bivalent compounds known as PROTACs (for 'proteolysis-targeting chimeras').

278 cluding activity-based protein profiling and proteolysis-targeting chimeras.

279 hannels lacking CNGB3 were more resilient to proteolysis than CNGA3/CNGB3 channels, suggesting a hind

280 zymes operate a more complex Gag polypeptide proteolysis than the HIV-1 protease, thus hypothetically

281 to be effectively regulated by extracellular proteolysis that is mediated by various enzymes.

282 to this hypothesis, we demonstrate following proteolysis that N- and C-termini of IP3 R1 remain assoc

283 for the enzymatic analyses of intramembrane proteolysis, the cleavage rate strongly depends on deter

284 After elution and proteolysis, the peptides were analyzed by mass spectrom

285 Arg/N-end rule pathway of ubiquitin-mediated proteolysis, through oxygen-dependent degradation of gro

286 ecessary for leucine generated via lysosomal proteolysis to exit lysosomes and activate mTORC1.

287 Here, we use limited proteolysis to investigate the role of the N and C termi

288 en the two proteins decreases, allowing ToxR proteolysis to proceed.

289 to Golgi to undergo regulated intramembrane proteolysis to release a cytosolic domain containing a b

290 ption) based on ligand-induced intramembrane proteolysis to reveal monosynaptic connections arising f

291 Da secreted VacA protein can undergo limited proteolysis to yield two domains, designated p33 and p55

292 levels through several mechanisms, including proteolysis, to permit their EMT and migration.

293 Stimulation of intracellular proteolysis using CBZ treatment may therefore be a clini

294 iotic chromosome axes are hubs for regulated proteolysis via SUMO-dependent control of the ubiquitin-

295 This proteolysis was inhibited by chymostatin and not GM6001.

296 Consequently, the kinetics of proteolysis were much slower for the rennet gel, confirm

297 erlin, we have applied the method of limited proteolysis, which allows nonspecific digestion of unfol

298 Prolonged periods of pepsin-mediated Pen a 1 proteolysis, which simulates gastric digestion, were req

299 Here, we identify a key role for proteolysis within the parasite lysosomal organelle (the

300 eptides similar to those expected from Arg-C proteolysis, yet with fewer missed and nonspecific cleav