ライフサイエンスコーパス: proteolytic

1 rt, Seo et al. provide evidence that the non-proteolytic 19S subunit of the 26S proteasome also regul

2 e-treated mice, which indicated that reduced proteolytic ability mediated the decreased migration tow

3 infectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions.

4 For some toxins, proteolytic activation and pro-peptide removal will faci

5 ings point to the involvement of KLK5 in the proteolytic activation and spread of seasonal influenza

6 Solubilization and proteolytic activation are necessary steps for PLB perme

7 f C1, suggesting instead that intermolecular proteolytic activation between neighboring C1 complexes

8 id full-length rNanI, further supporting the proteolytic activation of NanI activity.

9 Shear stress triggers DLL4-dependent proteolytic activation of NOTCH1 to expose the transmemb

10 nd sequestered within cells, which abolished proteolytic activation of pro-VEGFC.

11 We examine seven proteolytic activation reactions within the contact path

12 HK both enhances and suppresses these proteolytic activation reactions, depending on the speci

13 nt-binding proteins to the Golgi complex for proteolytic activation.

14 C-terminal half of prothrombin following its proteolytic activation.

15 tric function and to stimulate the stomach's proteolytic activities in FD.

16 Alterations to the proteolytic activities in the over-expressing and knock-

17 lective molecular recognition properties and proteolytic activities of more than two dozen membrane-b

18 The interdependence of these proteolytic activities provides a paradigm for non-apopt

19 e detection of protein-protein interactions, proteolytic activities, and posttranslational modificati

20 es, Neutrase(R) and Alcalase(R), at the same proteolytic activity (1U/mL), using an enzyme/substrate

21 how in this study are critical for balancing proteolytic activity and adhesive activity to achieve a

22 barrier integrity by stimulating endogenous proteolytic activity and defines a previously unknown me

23 ation (PNS) substantially reduces MV-induced proteolytic activity and oxidative stress in the diaphra

24 First, CYCLO stimulated lysosomal proteolytic activity by increasing cathepsin D activity,

25 NA, but the role of this interaction for Lon proteolytic activity has not been characterized.

26 This method is useful for determining the proteolytic activity in different media and its effectiv

27 e-like structures, which are associated with proteolytic activity in other cell types.

28 cific pattern of Lon isoform expression, Lon proteolytic activity induction, and H2O2 stress adaptati

29 female-specific Lon isoform expression, Lon proteolytic activity induction, and H2O2 stress adaptati

30 ycosylated, active protease and that its own proteolytic activity mediates zymogen cleavage.

31 The proteolytic activity of adam13 is critical for the relea

32 The proteolytic activity of APN promotes cancer angiogenesis

33 nt of alpha-actinin bands due to increase in proteolytic activity of calpain.

34 Last, we show that CpaB does not abolish the proteolytic activity of CpaA against human Factor V.

35 To date, the enzymes responsible for the proteolytic activity of German cockroach allergen have n

36 Taken together, the enhanced proteolytic activity of Gly1629Glu can be readily explai

37 ts represent the first reconstitution of the proteolytic activity of MamE and show that its behavior

38 However, only the CUB1 domain inhibited proteolytic activity of MDTCS.

39 The sensing mechanism was based on the proteolytic activity of S. aureus proteases on a specifi

40 tease-inhibitory domains, which regulate the proteolytic activity of serine proteases.

41 These tumours also displayed elevated proteolytic activity of the primary biochemical target o

42 e clones, lysosomal pH was increased and the proteolytic activity of these organelles was deranged.

43 Our data demonstrate that the proteolytic activity of thrombin negatively regulates th

44 In parallel, the proteolytic activity of tumor necrosis factor alpha-conv

45 ses (MMPs) can disrupt the BBB through their proteolytic activity on basement membrane and tight junc

46 CLL cells in vitro with MI-2 inhibited MALT1 proteolytic activity reduced BCR and NF-kappaB signaling

47 Allergens possess proteolytic activity that is capable of disrupting the a

48 y elevates proteasome subunit expression and proteolytic activity to eradicate nuclear FOXO4 proteins

49 e-activated receptor activation but requires proteolytic activity toward a novel substrate.

50 Of note, APC proteolytic activity was required for inhibiting NETosis

51 showed that albumin fraction (15-30 kDa) and proteolytic activity were negatively correlated with bre

52 ing-enzyme (ACE)-inhibition, antioxidant and proteolytic activity) of camel milk fermented with indig

53 hibitors, together with inhibitors of BoNT/A proteolytic activity, may be useful for reducing the mor

54 milder effects but still strongly diminished proteolytic activity, without affecting the subcellular

55 cific expression of Lon protein isoforms and proteolytic activity.

56 for Lon binding with DNA and effects on Lon proteolytic activity.

57 rt to lysosomes, thereby restoring lysosomal proteolytic activity.

58 ors (NgR1) as a downstream target of MT3-MMP proteolytic activity.

59 cleave the tripeptide S-2302, demonstrating proteolytic activity.

60 tion with mature TACE, thereby licensing its proteolytic activity.

61 chanisms, one of which is impaired lysosomal proteolytic activity.

62 ria is a highly controlled process involving proteolytic adaptors that regulate protein degradation d

63 The proteolytic and antioxidant activity of water soluble ex

64 es related to microbial activity, as well as proteolytic and lipolytic phenomena, decisive steps in s

65 se include proteins regulating inflammatory, proteolytic, and cytoskeletal functions.

66 nd to display resistance to gastrointestinal proteolytic attack.

67 were observed in the abundance of anaerobic, proteolytic bacteria such as Peptostreptococcus, Porphyr

68 se, leading to the generation of an invasive proteolytic bacterial surface.

69 of the ATPase spiral relative to the planar proteolytic base.

70 Similar proteolytic capacities were found in Staphylococcus epid

71 rily conserved process that governs cellular proteolytic capacity and eliminates inactive particles.

72 teins in ftsh4 was the limited ATP-dependent proteolytic capacity of ftsh4 mitochondria, arising from

73 e potential in mice of an Ab that blocks the proteolytic capacity of uPA in the CIA model and the del

74 A proteolytic cascade involving kallikrein and Factor XII

75 shed GBM cell invasion through impairing the proteolytic cascade of cathepsin B/urokinase-type plasmi

76 The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally act

77 vidence implicates serine proteinases in the proteolytic cascades leading to the pathological destruc

78 upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosac

79 lly to generate and recruit inflammatory and proteolytic cells.

80 substrates and their translocation into the proteolytic chamber of HslV.

81 and translocation to the negatively charged proteolytic chamber.

82 ring form the core complex that contains the proteolytic chamber.

83 Some of the proteolytic changes discovered in vitro also occurred in

84 1629Glu mutation drastically accelerates the proteolytic cleavage activity, even in the absence of fo

85 ogous to mammalian RIP1 that is regulated by proteolytic cleavage and Lys-63-polyubiquitination.

86 Proteolytic cleavage and NPC1 binding at endosomal pH le

87 The proteolytic cleavage and posttranslational acetylation m

88 Proteolytic cleavage and release from the cell surface o

89 ty, localization, and maturation, as well as proteolytic cleavage as a mediator in signaling pathways

90 of biological pathways that utilize specific proteolytic cleavage as a precision control mechanism in

91 ve disease, with unfolding, aggregation, and proteolytic cleavage as different facets of the process.

92 Using in vitro O-glycosylation and proteolytic cleavage assays, a cell line deficient in O-

93 of an intracellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a

94 First, that targeted, limited proteolytic cleavage events by a wide repertoire of prot

95 rmation of Gag via an orchestrated series of proteolytic cleavage events.

96 ell differentiation and is activated through proteolytic cleavage in response to ligand engagement.

97 We further show that Astn2 undergoes proteolytic cleavage in the second transmembrane domain

98 tification, mass spectrometry (MS), requires proteolytic cleavage in the vicinity of a PTM to yield p

99 Maturation by proteolytic cleavage is known to activate the enzyme.

100 Further, proteolytic cleavage of alpha1C is not required for beta

101 This interaction promotes a proteolytic cleavage of arid3a and its translocation to

102 Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG.

103 oluble HMW-EGF, that HMW-EGF is active, that proteolytic cleavage of pro-EGF first occurs at the C-te

104 LC3 undergoes two processing steps, the proteolytic cleavage of pro-LC3 and the de-lipidation of

105 les as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and t

106 lation of residues in alpha1C and C-terminal proteolytic cleavage of the alpha1C subunit.

107 Furthermore, we observed that proteolytic cleavage of the host extracellular matrix pr

108 Here, we provide evidence that proteolytic cleavage of the macrophage efferocytosis rec

109 s (GPCRs) that are irreversibly activated by proteolytic cleavage of the N terminus, which unmasks a

110 TLR7/8 activation leads to a furin-dependent proteolytic cleavage of the N-terminal part of FcgRIIA,

111 DSL ligands activate Notch by inducing proteolytic cleavage of the receptor ectodomain, an even

112 nnot be easily monitored (e.g. compared with proteolytic cleavage or amino acid phosphorylation); PDI

113 Differences in proteolytic cleavage patterns and chemical cross-linking

114 ee of hydrolysis (DH) observed suggests that proteolytic cleavage rapidly occurred within the first 1

115 ic Abs across epithelia to the mucosa, where proteolytic cleavage releases the ectodomain (secretory

116 mbrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1).

117 rulus in vivo We found evidence that defined proteolytic cleavage results in various proteoforms of i

118 2015, particularly at the hemagglutinin (HA) proteolytic cleavage site (PCS) that can affect virus ac

119 he covalently bound ligands did not mask any proteolytic cleavage sites of pepsin, trypsin or chymotr

120 Aap requires proteolytic cleavage to act as an intercellular adhesin.

121 S226A) into 5XFAD mice decreases APP and tau proteolytic cleavage, attenuates AD pathologies, and rev

122 are an autoantibody subclass that, following proteolytic cleavage, recognize cryptic epitopes exposed

123 increases open probability of the channel by proteolytic cleavage, resulted in significantly higher c

124 illogenesis in vitro, catalysed by selective proteolytic cleavage, which produces a high yield of gen

125 d deamidation, residual leader sequence, and proteolytic cleavage.

126 lipogenesis whose activity is controlled by proteolytic cleavage.

127 nly after the thioester bond is exposed by a proteolytic cleavage.

128 t, with a novel limitation of Dkk4 action by proteolytic cleavage.

129 ubset of Wnts, but is further inactivated by proteolytic cleavage.

130 m163S is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin form

131 The proteasome is a nuclear-cytoplasmic proteolytic complex involved in nearly all regulatory pa

132 the C-terminal 65 kDa to be labile in native proteolytic conditions in absence of the 20 kDa N-termin

133 (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases alphaFXIIa and a

134 Notably, proteolytic core and regulatory proteasome particles wer

135 Our analysis suggests that p28 assists the proteolytic core particle to select a specific conformat

136 use like most peptides, it is susceptible to proteolytic degradation and is challenging to synthesize

137 ects of proteasome inhibition indicated that proteolytic degradation controls agonist efficacy by set

138 Mutations disrupting this signal blunted proteolytic degradation downstream of E3 ubiquitin ligas

139 of the biofilms to multiple antibiotics and proteolytic degradation is significantly affected.

140 However, the proteolytic degradation of eIF4G alone by the human rhin

141 giogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intr

142 pericytes contribute to rapid and localized proteolytic degradation of the BBB during cerebral ische

143 th high affinity and specificity, leading to proteolytic degradation of the ERG protein.

144 However, their susceptibility to proteolytic degradation often limits their utility in th

145 cell stimulation, our findings indicate that proteolytic degradation tightly couples RGS2 transcripti

146 Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely

147 ofolate, are direct targets of As2O3-induced proteolytic degradation, providing a mechanism for arsen

148 aberrant and toxic proteins for refolding or proteolytic degradation.

149 amino acids (x and k), and was stable toward proteolytic degradation.

150 ity to reduce FXIIIA levels and function via proteolytic degradation.

151 portant role in the regulation of FXIIIA via proteolytic degradation.

152 losome (Cdc20-APC/C), thereby preventing the proteolytic destruction of securin and cyclin and delayi

153 Subsequent peptide-centric analysis, through proteolytic digestion of C9 and liquid chromatography (L

154 detect protease activity (trypsin) based on proteolytic digestion of protamine, and polyanions (pent

155 res of a set of glycopeptides resulting from proteolytic digestion of the well-characterized glycopro

156 multiplexed inhibitor beads with subsequent proteolytic digestion of unbound proteins and peptide-ba

157 the elongating new peptide, protect it from proteolytic digestion, and guide its emergence.

158 er the intact protein mass or, after on-chip proteolytic digestion, the peptide mass fingerprint and/

159 nvolved in disulfide bonding from nonreduced proteolytic digests, due to the concurrent detection of

160 o undergo a conformational change during the proteolytic disassembly of virions to infectious subviri

161 delivery of peptide therapeutics into highly proteolytic environments such as osteoarthritis.

162 c stationary phase for immobilization of the proteolytic enzyme pepsin.

163 Proteolytic enzymes (proteases) participate in a vast ra

164 enzymes with the milk proteins and the main proteolytic enzymes becomes important in determining the

165 For a long time, proteolytic enzymes have been employed as key tools of i

166 Proteolytic enzymes have shown efficacy in cancer therap

167 proaches to study activity and substrates of proteolytic enzymes in relevant biological models, both

168 hydrolysis of food proteins using commercial proteolytic enzymes is the most commonly employed proces

169 Genes in these regions include the proteolytic enzymes kallikrein (KLKB1) and Factor XII (F

170 and the system is subject to degradation by proteolytic enzymes that can break down its mechanical i

171 A low extracellular pH further activates proteolytic enzymes that remodel the extracellular matri

172 and selective reagents for a wide variety of proteolytic enzymes.

173 r significantly reduced upon hydrolysis with proteolytic enzymes.

174 In conclusion, this study identifies a novel proteolytic event that regulates the trafficking of VE-c

175 eadout to evaluate the single-turnover PCSK9 proteolytic event.

176 king that is important for VLP assembly, not proteolytic F cleavage.

177 nctional knowledge available for the central proteolytic fragment of the cascade, C3b.

178 Increased p25, a proteolytic fragment of the regulatory subunit p35, is k

179 MALDI-MS identified proteolytic fragments from ovalbumin and lysozyme, exhib

180 dependent excitatory synaptogenesis, via two proteolytic fragments generated by calpain cleavage.

181 For proteolytic fragments linked by more than one disulfide

182 Proteolytic fragments of Dau c 1 matched its T-cell-acti

183 our group have implicated calpain-dependent proteolytic fragments of menin, the product of the MEN1

184 CH, PSH and AMA in relation to levels of APP proteolytic fragments reported from AD-associated mutati

185 ke other LCAT enzymes it is cleaved into two proteolytic fragments that share the residues of the cat

186 ns have diverse effects on the levels of APP proteolytic fragments.

187 events on caspases have been shown to block proteolytic function by a number of mechanisms, so we so

188 esidue in certain BPH subfamilies, suggest a proteolytic function for BPH distinct from those of know

189 ed as a chemical probe to delineate Skp2 non-proteolytic function in tumorigenesis.

190 lete biochemical characterization of PCSK9's proteolytic function, which could inform therapeutic app

191 Recently, however, many non-proteolytic functions of ubiquitination have emerged as

192 Apoptotic activation triggered equivalent proteolytic gating of Panx1 channels in all three Jurkat

193 ter reactivity to ligand analogously to such proteolytic gating.

194 P. gingivalis secretes proteolytic gingipains (Kgp and RgpA/B) as zymogens inhi

195 ic digestion to increase the average mass of proteolytic IgG peptides (>/=4.5 kDa) and produce peptid

196 local availability and reduce the extent of proteolytic inactivation by other proteases in atheroscl

197 e of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage

198 s of peptides are currently limited by their proteolytic instability and impermeability to the cell m

199 Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.

200 a G protein-coupled receptor that undergoes proteolytic irreversible activation by coagulant and ant

201 The HslUV proteolytic machine consists of HslV, a double-ring self

202 nents forming and controlling this endosomal proteolytic machinery.

203 ing cells, researchers take advantage of the proteolytic maturation of HIV, type 1 (HIV-1), which can

204 y, invasion, and egress and are subjected to proteolytic maturation prior to organellar storage and d

205 red for capsid assembly and trypsin-mediated proteolytic maturation.

206 one in which VEGFD activation by a distinct proteolytic mechanism may be stimulated during inflammat

207 he necessity of NLGN3 for glioma growth, the proteolytic mechanism of NLGN3 secretion, and the furthe

208 mphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in whic

209 Podosomes are actin-based proteolytic microdomains of the plasma membrane found in

210 docyte cytoskeleton are regulated targets of proteolytic modification, which is altered upon podocyte

211 se proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targets these cargos

212 Proteolytic neuronal injury biomarkers (alphaII-spectrin

213 The proteolytic P-ring and the structurally similar R-ring f

214 larly important if a component of a relevant proteolytic pathway (e.g. a specific ubiquitin ligase) i

215 ted with enhanced proteasomal and autophagic proteolytic pathway activities and is triggered by inhib

216 partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system an

217 implying that other attachment sites and/or proteolytic pathways exist.

218 ntributions to pathogenesis by regulators of proteolytic pathways have become increasingly apparent.

219 vere sepsis, but it is unclear as to how the proteolytic pathways that are involved in its developmen

220 of candidate peptides through comparison of proteolytic peptides derived from the plasma of cancer p

221 n macrophages that maintains Mtb in spacious proteolytic phagolysosomes.

222 Several proteolytic processes were clearly site-specific, were c

223 P combination enhances mature glycosylation, proteolytic processing and cell-surface expression of al

224 mal degradation pathway and autophagy on the proteolytic processing and turnover of C99.

225 t a 25-kDa fragment, probably resulting from proteolytic processing by eta-secretase.

226 an unanticipated role of IN for polyprotein proteolytic processing during virion morphogenesis.

227 Site-specific mutagenesis to prevent proteolytic processing generated a full-length enzyme th

228 Proteolytic processing inside producing cells is a novel

229 Together, our data demonstrate that proteolytic processing is an important event that allows

230 sponsive transcription factor PacC, and PacC proteolytic processing occurred normally during calcium

231 beta-Amyloid peptides (Abeta), derived from proteolytic processing of amyloid precursor protein (APP

232 Proteolytic processing of amyloid precursor protein (APP

233 In addition, proteolytic processing of cadherin extracellular and cyt

234 edly, T124N/T174I IN substitutions inhibited proteolytic processing of HIV-1 polyproteins Gag and Gag

235 ediated knockout of caspase b, which acts by proteolytic processing of il1beta, results in increased

236 ubsequent study suggested that site-specific proteolytic processing of Nrf1 by the proteasome yields

237 aracterized the synaptic consequences of the proteolytic processing of Nrxns in cultured hippocampal

238 min-related protein 1) at Ser637 and altered proteolytic processing of OPA1 (optic atrophy 1).

239 ic function, we address the relevance of the proteolytic processing of presynaptic neurexins (Nrxns)

240 m open reading frame repression requires the proteolytic processing of PTEF by PfCalpain.

241 Proteolytic processing of synaptic adhesion components c

242 Proteolytic processing of the laminin-gamma2 chain is a

243 Proteolytic processing of the protein leads to a number

244 omplex array of glycosylation substrates and proteolytic processing of the transcription factor host

245 eavage fragments produced by pathogen-driven proteolytic processing should be further characterized t

246 Multiple proteolytic processing sites in Glass bottom boat (Gbb),

247 eavage of the transit peptide and additional proteolytic processing, mature HMR, which begins from Ly

248 cked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability t

249 oteins and activated by the inflammasome via proteolytic processing.

250 upling entry into the endocytic pathway with proteolytic processing.

251 post-translation modifications, isoforms and proteolytic processing.

252 terminus and 65 kDa carboxy terminus, after proteolytic processing.

253 endoplasmic reticulum (ER) to the Golgi for proteolytic processing.

254 via inhibition of CA-SP1 cleavage during Gag proteolytic processing.

255 that these mutant proteins were impaired in proteolytic processing.

256 ting in AMIGO2 silencing and changes in PTK7 proteolytic processing.

257 that S-OPA1 is a functionally insignificant proteolytic product of L-OPA1 because the accumulation o

258 evelopment and function of the CNS; however, proteolytic production of p25 from p35 under stress cond

259 ection in the absence of IFN-gamma, where L1 proteolytic products are produced during endosomal capsi

260 Morphine alters the circulating proteolytic profile in mice: functional consequences on

261 f morphine administration on the circulating proteolytic profile of tumor-free mice.

262 ion, in inducing blood coagulation by direct proteolytic ProT activation.

263 Here, we report the discovery of a proteolytic regulator of CHS, namely, KFB(CHS), a Kelch

264 ional Readout with rapid Kinetics), in which proteolytic release of a membrane-tethered transcription

265 erated by TNF-alpha converting enzyme (TACE) proteolytic release of the transmembrane TNF (tmTNF) ect

266 ight-induced changes in gene expression, the proteolytic removal of specific proteins by the ubiquiti

267 placing glutamate with aspartate in an HCF-1 proteolytic repeat was shown to prevent peptide backbone

268 transgenic mice with inducible expression of proteolytic-resistant alpha1C Prevention of C-terminal c

269 ry analyses results in variants with greater proteolytic robustness.

270 In addition to its proteolytic roles, the 26S proteasome is involved in reg

271 s into the core particle, which contains the proteolytic sites of the proteasome.

272 These proteolytic sites were identified with the intact molecu

273 Two proteolytic sites within the GLP1 peptide sequence of du

274 trategy is now reported to increase both the proteolytic stability and cell permeability of peptidyl

275 ulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability.

276 Furthermore, we improved the proteolytic stability by substituting the N-terminal arg

277 uch suppressor changes resulted in decreased proteolytic stability of the Rz double mutants in vivo U

278 te specific protein interactions to increase proteolytic stability or tune activation of different si

279 ainst HIV-1 infection and markedly increased proteolytic stability relative to its disulfide-tethered

280 h submicromolar affinities for TNKS and high proteolytic stability that are able to disrupt the inter

281 A polyamide backbone is used for tuning the proteolytic stability to avoid retention within the body

282 site ("RPRL" motif) showed improved in vitro proteolytic stability while maintaining receptor-binding

283 Peptide 12f exhibited proteolytic stability, with no apparent hemolytic activi

284 ake in two different cell lines and improved proteolytic stability.

285 ty of 3 while preserving its selectivity and proteolytic stability.

286 activity, substrate binding, and thermal and proteolytic stability.

287 However, the proteolytic substrates of MarP that mediate these phenot

288 ClpXP is composed of a proteolytic subunit, ClpP, and a chaperone-like subunit,

289 ctivation to the protease plasmin generate a proteolytic surface that GAS employs to circumvent host

290 ing of the roles these fragments and the APP proteolytic system as a whole in normal aging and diseas

291 In Escherichia coli, a proteolytic system comprising the periplasmic PDZ-protea

292 o the effects of mutations in APP as the APP proteolytic system has not been investigated systematica

293 e of accommodating the complexity of the APP proteolytic system is required to integrate available ev

294 s the recognition component of the GID-based proteolytic system termed the Pro/N-end rule pathway.

295 Deregulation of proteolytic systems is a known path leading to disease m

296 age of proteins for degradation by different proteolytic systems, the common characteristic shared by

297 ins talin and focal adhesion kinase (FAK) as proteolytic targets of calpain in Xenopus laevis spinal

298 ted that Calotropis procera extract was more proteolytic than chymosin and that kappa-casein was prot

299 Non-proteolytic ubiquitin signaling mediated by Lys(63) ubiq

300 particles and become increasingly acidic and proteolytic, ultimately fusing with lysosomes, in a proc