ライフサイエンスコーパス: proteolytic activation

1 d annexin-V staining, and caspase-3-mediated proteolytic activation.

2 as expected for mutations that block Rim101p proteolytic activation.

3 vealed that procaspases form dimers prior to proteolytic activation.

4 ve site in Plg(R561A), a mutant that resists proteolytic activation.

5 z-VAD-fmk also prevented PKCdelta and betaI proteolytic activation.

6 and that proteinuria contributes to aberrant proteolytic activation.

7 system, but it was only weakly active after proteolytic activation.

8 h likely remains bound to the receptor after proteolytic activation.

9 s directed at Lewis(y), all of which require proteolytic activation.

10 vides a mechanism for peptide inhibition and proteolytic activation.

11 cts downstream of, or in parallel to, Relish proteolytic activation.

12 o expose the ADAM cleavage site and initiate proteolytic activation.

13 nt-binding proteins to the Golgi complex for proteolytic activation.

14 C-terminal half of prothrombin following its proteolytic activation.

15 hat the C-terminal helix is formed only upon proteolytic activation.

16 he caspases tested, only caspase-7 underwent proteolytic activation after stimulation with lovastatin

17 m of Pseudomonas exotoxin that does not need proteolytic activation and a disulfide-stabilized Fv fra

18 Pseudomonas exotoxin (PE) that does not need proteolytic activation and a disulfide-stabilized Fv fra

19 By bypassing the need for proteolytic activation and decreasing molecular size we

20 a) remains in a zymogen-like state following proteolytic activation and depends on interactions with

21 histone acetylation, Protein kinase C delta proteolytic activation and DNA fragmentation in dopamine

22 1), which encodes a repressor blocking Srebp proteolytic activation and has targeting sites of miR-33

23 oxin, termed B1(dsFv)-PE33, does not require proteolytic activation and it is smaller than other immu

24 For some toxins, proteolytic activation and pro-peptide removal will faci

25 tion of Tyr-311 on PKCdelta can regulate the proteolytic activation and proapoptotic function of the

26 morphic epidermis revealed reduced prostasin proteolytic activation and profilaggrin proteolytic proc

27 ted receptor 1 (PAR-1) and instead reflected proteolytic activation and release of HGF with subsequen

28 ings point to the involvement of KLK5 in the proteolytic activation and spread of seasonal influenza

29 clear transport of active caspase-3 required proteolytic activation and substrate recognition.

30 ological processing of protoxin: solubility, proteolytic activation, and insertion into the Tm-BBMV.

31 Solubilization and proteolytic activation are necessary steps for PLB perme

32 hesized as inactive proproteins that undergo proteolytic activation as they travel through the eukary

33 ts could be attributed to thrombin-dependent proteolytic activation as well as vWbp-mediated non-prot

34 gical activator of pro-PSA following its own proteolytic activation, as part of a cascade system invo

35 f C1, suggesting instead that intermolecular proteolytic activation between neighboring C1 complexes

36 in MMP7(-/-) cecum and colon due to luminal proteolytic activation by alternative host and microbial

37 sembles into an inert particle that requires proteolytic activation by furin to enable transmission t

38 Bone morphogenetic proteins (BMPs) require proteolytic activation by members of the proprotein conv

39 pheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family a

40 (F1) domain, plays an essential role in its proteolytic activation by prothrombinase.

41 rses the sterol-mediated inhibition of SREBP proteolytic activation by reducing the level of Insig-1

42 hemolytic activity; 3) for susceptibility to proteolytic activation by the alternative pathway and co

43 on peptide, ap, is cleaved from fVIII during proteolytic activation by thrombin or factor Xa.

44 l connection, we show that cage assembly and proteolytic activation can be uncoupled.

45 rop2 ICD by enhancing abundance of the Trop2 proteolytic activation complex.

46 nts in picornaviral polymerases, including a proteolytic activation-dependent N-terminal structure th

47 Caspase-7, but not caspase-3, underwent proteolytic activation during lovastatin-induced apoptos

48 erved: hyperphosphorylation for PKCalpha and proteolytic activation for PKC delta and betaI.

49 tosis is executed by caspases, which undergo proteolytic activation in response to cell death stimuli

50 -I and -II proteins are required for Rim101p proteolytic activation in S. cerevisiae.

51 ting it from escorting SREBPs to the site of proteolytic activation in the Golgi complex.

52 from escorting SREBPs from ER to the site of proteolytic activation in the Golgi complex.

53 eavage products of CED-3 associated with its proteolytic activation in vivo.

54 Proteolytic activation is a unique feature of the epithe

55 tional exposure of the heavy chain following proteolytic activation is required for inhibition.

56 In contrast to the classical proteolytic activation mechanism of trypsinogen-like ser

57 The irreversibility of PAR1's proteolytic activation mechanism stands in contrast to t

58 of G protein-coupled receptors with a unique proteolytic activation mechanism.

59 Neither proteolytic activation nor nuclear localization of SRE-B

60 ourse of limited trypsinolysis revealed that proteolytic activation occurred following cleavage of a

61 ic studies of the coupled conformational and proteolytic activation of [Lys]Pg, SKDeltaK414 exhibited

62 Thrombomodulin also accelerates the proteolytic activation of a plasma procarboxypeptidase r

63 on in a multiplexed format, and tracking the proteolytic activation of an inactive pro-protease to it

64 pressure homeostasis, and is responsible for proteolytic activation of angiotensin I to angiotensin I

65 terior of cells, that it plays a role in the proteolytic activation of anthrax toxin PA, and that PAC

66 Collectively, these results indicate that proteolytic activation of Bid and the subsequent inducti

67 in converting enzyme-1 (ECE-1) catalyzes the proteolytic activation of big endothelin-1 to endothelin

68 membranes play a significant role during the proteolytic activation of blood coagulation proteins.

69 A activator is reported and it is shown that proteolytic activation of both subunits is essential for

70 complement by binding to C3b and inhibiting proteolytic activation of C3 and C5.

71 ear residue 865, appears to be important for proteolytic activation of C5.

72 that eventually led to cytochrome c release, proteolytic activation of caspase 3 and PARP1, and execu

73 Proteolytic activation of caspase 3 was determined by im

74 l-2, cytochrome c release from mitochondria, proteolytic activation of caspase-3 and -9, and cleavage

75 k and by cycloheximide, which also prevented proteolytic activation of caspase-3 and poly(ADP-ribose)

76 l interfering RNAs abrogated the UVB-induced proteolytic activation of caspase-3 in these cells.

77 poptosis during myogenesis by inhibiting the proteolytic activation of caspase-3, whereas the R120G a

78 s link spontaneous monocyte apoptosis to the proteolytic activation of caspase-3.

79 Subsequent proteolytic activation of caspase-8 at the DISC leads to

80 s receptor Fas, resulting in recruitment and proteolytic activation of caspase-8, which initiates the

81 onsistent with this idea, Aven inhibited the proteolytic activation of caspases in a cell-free extrac

82 mple interaction with zAsc, induced specific proteolytic activation of Caspy and enhanced Caspy-depen

83 Expression of CED-4 enhances the proteolytic activation of CED-3.

84 ular patterns and include identical steps of proteolytic activation of complement component C4, forma

85 Proteolytic activation of CREBH in the liver exhibits ty

86 somes" that activate caspase-1, resulting in proteolytic activation of cytokines interleukin (IL)-1be

87 portant functions in processes as diverse as proteolytic activation of cytokines, cell death, and mem

88 of Ca(2+), most probably by Ca(2+)-dependent proteolytic activation of Dicer.

89 ic activation of initiator caspases leads to proteolytic activation of downstream (effector) caspases

90 Consequently P49 blocked proteolytic activation of effector caspases at a unique

91 xpression levels increased, and blocking the proteolytic activation of either MMP-9 or uPA inhibited

92 In Xenopus laevis oocytes, we monitored proteolytic activation of ENaC currents and the appearan

93 To evaluate the possibility that proteolytic activation of ENaC may contribute to the vir

94 ine protease inhibitors, which might prevent proteolytic activation of ENaC.

95 ted by overexpressed Insig-1, which prevents proteolytic activation of endogenous SREBPs.

96 cell adhesion molecule, and also Ctr-induced proteolytic activation of epithelial cell adhesion molec

97 PreF(0) cleavage was completed before proteolytic activation of F(0) into its F(1) and F(2) su

98 more consistent with the interpretation that proteolytic activation of factor V simply eliminates ste

99 Thrombin catalyzes the proteolytic activation of factor VIII, cleaving two site

100 ng was selective with an IC(50) of 30 nM for proteolytic activation of factor X by the TF(1-218)-VIIa

101 proteases, the details of the mechanisms of proteolytic activation of fusion are still incompletely

102 n of FV, which is normally released upon the proteolytic activation of FV by thrombin and binds tight

103 eutralize FVIII activity by interfering with proteolytic activation of FVIII by thrombin or factor Xa

104 ric structure of FXI is essential for normal proteolytic activation of FXI by FXIIa, thrombin, or FXI

105 , required prothrombin and triggered the non-proteolytic activation of FXIII in vitro.

106 ytic activation as well as vWbp-mediated non-proteolytic activation of FXIII zymogen.

107 tic and nonproteolytic mechanisms, including proteolytic activation of hepatocyte growth factor.

108 Most notably, circumventing the defect in proteolytic activation of Hgf by the downstream expressi

109 We demonstrate here that proteolytic activation of hPAK65, a p21-activated kinase

110 s responsible for the inflammasome-dependent proteolytic activation of IL-1 cytokine family members,

111 nflammatory caspase-1 is responsible for the proteolytic activation of IL-1beta.

112 defensins, termed cryptdins (Crps), requires proteolytic activation of inactive precursors (pro-Crps)

113 f mouse alpha-defensins (cryptdins) requires proteolytic activation of inactive precursors by matrix

114 Proteolytic activation of initiator procaspases is a cru

115 FD potently prevented factor D (FD)-mediated proteolytic activation of its macromolecular substrate C

116 ate, C1 inhibitor (C1 inh), and promotion of proteolytic activation of its natural substrate, C4.

117 It was previously shown that proteolytic activation of lysyl oxidase is much reduced

118 The important role of furin in the proteolytic activation of many pathogenic molecules has

119 eaved by furin, the protease responsible for proteolytic activation of many viral fusion proteins.

120 e conformational changes associated with the proteolytic activation of matriptase.

121 Mammalian lipid homeostasis requires proteolytic activation of membrane-bound sterol regulato

122 Proteolytic activation of membrane-bound transcription f

123 Proteolytic activation of MERS-S during viral uptake int

124 show that the lipid environment controls the proteolytic activation of Mga2 by stabilizing alternativ

125 e studies suggest a novel regulation for the proteolytic activation of MMP-9 in human tissue, which i

126 MMP expression, resulting in the coordinated proteolytic activation of MMP2, and (ii) a receptor-medi

127 cell functions, including cell migration and proteolytic activation of MMP2.

128 ents and IL-13, most likely by mediating the proteolytic activation of MMPs.

129 -SP1-specific antibody inhibitor blocked the proteolytic activation of MSP-1 at the cell surface of p

130 id full-length rNanI, further supporting the proteolytic activation of NanI activity.

131 ease inhibitors become diluted, allowing for proteolytic activation of near-silent channels, and (iii

132 Gamma secretase inhibitors (GSI) block proteolytic activation of NOTCH receptors and may provid

133 In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vi

134 Shear stress triggers DLL4-dependent proteolytic activation of NOTCH1 to expose the transmemb

135 e host cell serine endoprotease furin in the proteolytic activation of numerous pathogens points to t

136 ngth PAK-2 stimulates cell survival, whereas proteolytic activation of PAK-2p34 is involved in progra

137 Thus, proteolytic activation of PAK2 represents a guanosine tr

138 binding to alpha(9)beta(1) and simultaneous proteolytic activation of PAR-1.

139 In podocytes, aPC inhibits apoptosis through proteolytic activation of PAR-3 independent of endotheli

140 In this study, we report that proteolytic activation of PAR1 by thrombin induces persi

141 alloprotease of Listeria, is involved in the proteolytic activation of PC-PLC.

142 on of PC-PLC or Mpl, the enzyme required for proteolytic activation of PC-PLC.

143 alloprotease of Listeria, is involved in the proteolytic activation of PC-PLC.

144 lle structures may be similarly dependent on proteolytic activation of physiological fibrillogenic su

145 The findings suggest that proteolytic activation of PKC delta by a CPP32-like prot

146 H(2)O(2)-induced proteolytic activation of PKC was delta mediated by the

147 These findings support proteolytic activation of PKCdelta in the cellular respo

148 se data demonstrate that caspase-3-dependent proteolytic activation of PKCdelta plays a key role in o

149 SSPD downward arrow G (D383A) site inhibited proteolytic activation of PKCepsilon.

150 hese results suggest that the expression and proteolytic activation of PKCeta play an important role

151 -promoting activity essentially required the proteolytic activation of plasminogen and was completely

152 genesis thus involves two maturation events: proteolytic activation of POMC in ISGs and a transition

153 ouse Paneth cell alpha-defensins require the proteolytic activation of precursors by matrix metallopr

154 bactericidal activity of cryptdins requires proteolytic activation of precursors by matrix metallopr

155 region inhibited Apaf-1 self-association and proteolytic activation of pro-casp9.

156 Substantial proteolytic activation of pro-caspase 3 was relatively d

157 y proteins did not prevent caspase-8-induced proteolytic activation of pro-caspase-3; however, they s

158 The proteolytic activation of pro-matrix metalloproteinase (

159 Furthermore, TNF-alpha promotes proteolytic activation of pro-MMP-9 by conversion of the

160 We found that proteolytic activation of pro-MMP-9 was mediated by a ti

161 orm of MSP in circulating blood and to study proteolytic activation of pro-MSP by its target cell.

162 ion, as well as delays and reductions in the proteolytic activation of pro-sigmaE and sigmaE-directed

163 ic gene expression that is essential for the proteolytic activation of pro-sigmaE in the neighbouring

164 nd sequestered within cells, which abolished proteolytic activation of pro-VEGFC.

165 show that Smac/DIABLO promotes not only the proteolytic activation of procaspase-3 but also the enzy

166 Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the

167 itical event in the apoptotic cascade is the proteolytic activation of procaspases to active caspases

168 Proteolytic activation of prophenoloxidase in insects is

169 duced chemotaxis of monocytes is mediated by proteolytic activation of protease-activated receptor-1

170 e mediator of thrombus formation through the proteolytic activation of protease-activated receptors (

171 rophil elastase inhibitor (NEI), blocked the proteolytic activation of protegrins and diminished the

172 ion cascade, its main role is catalyzing the proteolytic activation of prothrombin to thrombin.

173 talytic mechanism that is distinct from GD's proteolytic activation of Snk.

174 ions extracellularly, likely by blocking the proteolytic activation of Spaetzle, the Toll receptor li

175 1 enhances the ability of sterols to inhibit proteolytic activation of SREBP-1, which activates trans

176 In previous studies with cultured cells, proteolytic activation of SREBP-1a and SREBP-2 has been

177 nt of SCAP/SREBP to the Golgi and consequent proteolytic activation of SREBP.

178 olesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degrad

179 oplasmic reticulum to the Golgi, followed by proteolytic activation of SREBPs by S1P and S2P in the G

180 a membrane-bound glycoprotein, regulates the proteolytic activation of sterol regulatory element bind

181 ene 1 (INSIG1) encodes a protein that blocks proteolytic activation of sterol regulatory element bind

182 of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-bind

183 of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-bind

184 It is possible that the proteolytic activation of TEPs is a target of host-paras

185 equired for efficient ER exit and subsequent proteolytic activation of the alpha/beta-subunit precurs

186 We found that ER stress induces proteolytic activation of the BH3-only protein BID as a

187 Proteolytic activation of the caspase-3 precursor was de

188 p17 peptide fragment, which results from the proteolytic activation of the caspase-3 precursor, was d

189 rved in IPAH PASMCs was directly impacted by proteolytic activation of the cell cycle regulator, host

190 hat Na(+) regulates ENaC in part by altering proteolytic activation of the channel.

191 Although proteolytic activation of the complement protein C5 init

192 9 and -8, respectively) that converge on the proteolytic activation of the downstream executioner cas

193 er fluid secretion and pathogen clearance by proteolytic activation of the epithelial sodium channel

194 yrosine residue in PKCdelta can regulate the proteolytic activation of the kinase during oxidative st

195 resistant acid phosphatase 5b was expressed, proteolytic activation of the latent pro-enzyme was inhi

196 r proteins LC3-II and p62, and decreased the proteolytic activation of the lysosomal hydrolase cathep

197 ro-inflammatory and pro-fibrotic effects via proteolytic activation of the major thrombin receptor, p

198 The proteolytic activation of the membrane-associated transc

199 The proteolytic activation of the mother cell transcription

200 suggest that PS1 plays a central role in the proteolytic activation of the Notch-1-signaling pathway

201 These responses are often accompanied by proteolytic activation of the phenoloxidase zymogen that

202 crobial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines

203 Proteolytic activation of the protective antigen (PA) co

204 fic thrombin substrate and thereby regulates proteolytic activation of the protein cofactor.

205 propeptide dissociated from the toxin after proteolytic activation of the protoxin (AT(pro)) and to

206 ion as a signaling platform that enables the proteolytic activation of the Rim101 transcription facto

207 activates human fibrinolysis by inducing non-proteolytic activation of the serine proteinase zymogen,

208 by cholesterol through its inhibition of the proteolytic activation of the sterol regulatory element

209 this type of recombinant toxin does not need proteolytic activation of the toxin domain.

210 th in neutral-alkaline environments requires proteolytic activation of the transcription factor Rim10

211 Such processing includes proteolytic activation of the zymogen for lysyl oxidase.

212 Proteolytic activation of these proteins results in a co

213 lecular signaling complexes that control the proteolytic activation of two highly proinflammatory IL-

214 Phagocytosis triggered the proteolytic activation of two lipogenic transcription fa

215 e caerulein have been shown to stimulate the proteolytic activation of zymogens within the pancreatic

216 After proteolytic activation on the host cell surface, PA form

217 After proteolytic activation, only conditioned media from COS

218 Nuclear translocation does not involve proteolytic activation or degradation of scuPA.

219 leaved kininogen index (CKI), an index of HK proteolytic activation or HK and LK destruction (with re

220 s but had no effect on its receptor binding, proteolytic activation, or ability to oligomerize and bi

221 Given its irreversible mechanism of proteolytic activation, PAR(2) is a model to study the p

222 Caspase-mediated proteolytic activation parallels cell death and appears

223 pparently is made as a zymogen that requires proteolytic activation, possibly by furin intracellularl

224 We examine seven proteolytic activation reactions within the contact path

225 HK both enhances and suppresses these proteolytic activation reactions, depending on the speci

226 s synthesized as a procytokine that requires proteolytic activation, release of the mature cytokine f

227 Proteolytic activation removes most of the regulatory do

228 Consistent with the known proteolytic activation requirement for ETX toxicity, try

229 reactive site loop strikingly similar to the proteolytic activation site in prophenoloxidase (pro-PO)

230 rg-Val-Val-Gly-Gly motif that may serve as a proteolytic activation site.

231 e HIV-1 envelope glycoprotein (Env) requires proteolytic activation; specifically, cleavage of a gp16

232 Our observations reveal a proteolytic activation step in the malarial PV that may

233 We show that this proteolytic activation step occurs in the gut of lepidop

234 After binding to cellular receptors and proteolytic activation, the protective antigen component

235 ender NOTCH1 sensitive to ligand-independent proteolytic activation through two distinct mechanisms.

236 that the full-length CED-3 protein undergoes proteolytic activation to generate a CED-3 cysteine prot

237 enzyme, mainly by macrophages, and undergoes proteolytic activation to generate an active form.

238 kDa precursor (IL-1alpha p), which undergoes proteolytic activation to release the mature carboxyl te

239 omoting prostate stem cell self-renewal upon proteolytic activation via a gamma-secretase cleavage co

240 Spz3 expression in muscle and proteolytic activation via the Easter protease was neces

241 Proteolytic activation was also observed with a substrat

242 H2O2-mediated caspase-3 proteolytic activation was inhibited by anti-TfR antibod

243 3 was detected in monocyte extracts, but its proteolytic activation was not efficient in the presence

244 Upon proteolytic activation with cathepsin S (EC 3.4.22.27),

245 carboxypeptidase activity that develops upon proteolytic activation with the release of an activation