ライフサイエンスコーパス: proteolytic cleavage

1 ynthesized as a zymogen that is activated by proteolytic cleavage.

2 ovarian tumor cells reduces PAR-2 N-terminal proteolytic cleavage.

3 d to the shielding of its adhesion sites and proteolytic cleavage.

4 ion, revealing a mechanistic requirement for proteolytic cleavage.

5 modeling, this loop was extremely labile to proteolytic cleavage.

6 ng residues are exposed at the N terminus by proteolytic cleavage.

7 d deamidation, residual leader sequence, and proteolytic cleavage.

8 , either through terminal differentiation or proteolytic cleavage.

9 lipogenesis whose activity is controlled by proteolytic cleavage.

10 nly after the thioester bond is exposed by a proteolytic cleavage.

11 t, with a novel limitation of Dkk4 action by proteolytic cleavage.

12 ubset of Wnts, but is further inactivated by proteolytic cleavage.

13 destabilization through receptor binding and proteolytic cleavage.

14 can reverse this by controlled intracellular proteolytic cleavage.

15 g protein, specifically by inhibiting CA-SP1 proteolytic cleavage.

16 ndoplasmic reticulum, disulfide bonding, and proteolytic cleavage.

17 initiates hemostasis before inactivation by proteolytic cleavage.

18 often were assumed to be due to nonspecific proteolytic cleavages.

19 ne leukemia virus Env protein matures by two proteolytic cleavages.

20 ural protein VP90 and undergoes a cascade of proteolytic cleavages.

21 5 to be MUC16, it is hypothesized to undergo proteolytic cleavage, a process that is considered to be

22 rane endothelial adhesion molecule and, upon proteolytic cleavage, a soluble chemoattractant for circ

23 ast, in the late phase (72 h), when the NCX3 proteolytic cleavage abruptly ceased, the occurrence of

24 Cyclin D1 induced abundance of the Trop2 proteolytic cleavage activation components (PS2, TACE) a

25 we demonstrate that kidney lysate possesses proteolytic cleavage activity toward SPAK.

26 1629Glu mutation drastically accelerates the proteolytic cleavage activity, even in the absence of fo

27 ent on the ATP-binding activity of RPT6, but proteolytic cleavage additionally requires its ATPase ac

28 L in multivesicular bodies is protected from proteolytic cleavage and 2) upon secretion, delivery of

29 growth factor by a protein that enhances its proteolytic cleavage and activation.

30 ks sterol regulatory element-binding protein proteolytic cleavage and activation.

31 ibility complex (MHC) molecules (MHCII) from proteolytic cleavage and assist in arranging proteins wi

32 In contrast, V634M fVIII undergoes proteolytic cleavage and dissociation from VWF.

33 -cell cross-presentation of insulin required proteolytic cleavage and endosomal localization and was

34 tein-coupled receptors that are activated by proteolytic cleavage and generation of a tethered ligand

35 form oligomeric pores in membranes following proteolytic cleavage and interaction with cell surface r

36 Based on these proteolytic cleavage and internalization mechanism, we d

37 ogous to mammalian RIP1 that is regulated by proteolytic cleavage and Lys-63-polyubiquitination.

38 Proteolytic cleavage and NPC1 binding at endosomal pH le

39 terminal cytoplasmic tail of PC1 can undergo proteolytic cleavage and nuclear translocation.

40 tive on the complexity of TLR9 regulation by proteolytic cleavage and offer potential ways to inhibit

41 The proteolytic cleavage and posttranslational acetylation m

42 Its surface glycoproteins undergo proteolytic cleavage and rearrangements to permit membra

43 Proteolytic cleavage and release from the cell surface o

44 IL-1beta enhanced the proteolytic cleavage and release of COMP from tendon exp

45 aling independent of direct cell contact and proteolytic cleavage and suggest the participation of Ep

46 teraction"), making it highly susceptible to proteolytic cleavage and the generation of neurotoxic fr

47 serine proteases through specific N-terminal proteolytic cleavage and the unmasking of a tethered lig

48 st to previous studies, which implicated Aap proteolytic cleavage and, specifically, the Aap B domain

49 al regions are highly protected from HDX and proteolytic cleavage and, thus, are part of the fibrilla

50 precipitation, an enhanced susceptibility to proteolytic cleavage, and a loss of viral protein activi

51 facilitates the study of the glycosylation, proteolytic cleavage, and shedding of fibrocystin.

52 Reports have identified proteolytic cleavage as a mechanism capable of releasing

53 ty, localization, and maturation, as well as proteolytic cleavage as a mediator in signaling pathways

54 of biological pathways that utilize specific proteolytic cleavage as a precision control mechanism in

55 ve disease, with unfolding, aggregation, and proteolytic cleavage as different facets of the process.

56 s, which liberate fluorescent reporters upon proteolytic cleavage, as well as acid phosphatase cytoch

57 Using in vitro O-glycosylation and proteolytic cleavage assays, a cell line deficient in O-

58 Recently, it has been postulated that proteolytic cleavage at Ala(1800) and protein kinase A p

59 tro-translated Nup98 with 2A(pro) results in proteolytic cleavage at multiple sites in vitro, indicat

60 ggers dephosphorylation at several sites and proteolytic cleavage at one of these sites, resulting in

61 hesized as pro-PanD, which undergoes an auto-proteolytic cleavage at residue Ser25 to yield the catal

62 yaluronan receptor CD44 undergoes sequential proteolytic cleavage at the cell surface.

63 mAb4C11) and the neoepitope generated after proteolytic cleavage at the prostasin/kallikrein cleavag

64 are G protein-coupled receptors activated by proteolytic cleavage at their amino termini by serine pr

65 rsor (chem163S), and its activation requires proteolytic cleavages at its C terminus, involving prote

66 S226A) into 5XFAD mice decreases APP and tau proteolytic cleavage, attenuates AD pathologies, and rev

67 prion protein (PrPC) undergoes constitutive proteolytic cleavage between residues 111/112 to yield a

68 ructural changes in collagen associated with proteolytic cleavage by both enzymes.

69 We show that proteolytic cleavage by CalpA generates Cactus fragments

70 pro-IL-1beta is a complex process involving proteolytic cleavage by caspase-1.

71 The proteolytic cleavage by gamma-secretase of its C-termina

72 al IL-15Ralpha was shed by keratinocytes via proteolytic cleavage by matrix metalloproteinases upon s

73 es the susceptibility of the core protein to proteolytic cleavage by matrix metalloproteinases.

74 ein-coupled receptor that is activated after proteolytic cleavage by serine proteases, including mast

75 rom its full-length 135-kDa precursor though proteolytic cleavage by serine proteases.

76 of an intracellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a

77 leavage sites, thus allowing activation upon proteolytic cleavage by the respective proteases.

78 possesses inflammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypepti

79 PAR-2 is activated via proteolytic cleavage by trypsin-like serine proteases, i

80 rms that arise from alternative splicing and proteolytic cleavage during inflammatory responses.

81 on for CIDEB downregulation, which utilize a proteolytic cleavage event that is independent of the ce

82 that the imposition of ER stress leads to a proteolytic cleavage event that selectively removes the

83 in vivoresults in CIDEB downregulation via a proteolytic cleavage event.

84 First, that targeted, limited proteolytic cleavage events by a wide repertoire of prot

85 Alterations--such as deletion, mutation, and proteolytic cleavage events--to the extracellular ligand

86 rmation of Gag via an orchestrated series of proteolytic cleavage events.

87 d amino-acid residue(s) can be identified by proteolytic cleavage followed by liquid chromatography-m

88 Diminished levels of VAPB and its proteolytic cleavage fragment have also been reported in

89 m of 2C that then becomes fully activated by proteolytic cleavage from the adjacent 2B viroporin doma

90 for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA)

91 s a discrete native-like trimer and that its proteolytic cleavage generates the mature glycoprotein.

92 ell differentiation and is activated through proteolytic cleavage in response to ligand engagement.

93 er, the role of histone variants and histone proteolytic cleavage in senescence remains unclear.

94 FGFR3 was previously shown to undergo proteolytic cleavage in the bovine rib growth plate, but

95 It is also recognized that apoE undergoes proteolytic cleavage in the brain and the resultant apoE

96 Proteolytic cleavage in the hinge region by tumor-associ

97 We further show that Astn2 undergoes proteolytic cleavage in the second transmembrane domain

98 tification, mass spectrometry (MS), requires proteolytic cleavage in the vicinity of a PTM to yield p

99 tly hypothesized, crucial pathogenic role of proteolytic cleavage in TTR amyloid fibrillogenesis.

100 g to obtain and have been thought to require proteolytic cleavage into two-component subunits, gp120

101 In fact, the fate of pVIn following proteolytic cleavage is completely unknown.

102 binding by API2-MALT1 is API2 dependent and proteolytic cleavage is dependent on MALT1 paracaspase a

103 ing of SREBP-2, a transcription factor whose proteolytic cleavage is known to activate a variety of p

104 Maturation by proteolytic cleavage is known to activate the enzyme.

105 In the case of human adenovirus, this proteolytic cleavage is mediated by the virally encoded

106 Proteolytic cleavage is not required for TLR3 signaling

107 Proteolytic cleavage is stimulated by an anti-alpha5/bet

108 se assembly depends on a conserved, specific proteolytic cleavage leading to conformational activatio

109 Proteolytic cleavages led to the generation of two solub

110 dysfunction in dry eye, and that galectin-3 proteolytic cleavage may contribute to impaired ocular s

111 loss of membrane-tethered VTCN1 is linked to proteolytic cleavage mediated by the metalloproteinase n

112 level, neuronal death is accompanied by the proteolytic cleavage, misfolding and aggregation of hunt

113 mutations in the FGF23 (176)RXXR(179)/S(180) proteolytic cleavage motif can cycle from unaffected sta

114 t shock protein 27 (HSP27), to block the two proteolytic cleavages necessary for the formation of ful

115 nally truncated version, suggesting that the proteolytic cleavage occurs before or during fibre forma

116 s spectrometric analysis confirms that major proteolytic cleavage occurs within a region that is sele

117 Proteolytic cleavage occurs within a serine-rich, intrin

118 demonstrate that sEGFR is generated through proteolytic cleavage of a cell surface precursor of an a

119 NGF is derived by proteolytic cleavage of a large precursor protein, proNG

120 y virus type 1 (HIV-1) virions is derived by proteolytic cleavage of a trimeric gp160 glycoprotein pr

121 Blood ACE concentrations are determined by proteolytic cleavage of ACE from the endothelial cell su

122 Further, proteolytic cleavage of alpha1C is not required for beta

123 By inducing acute cell-surface proteolytic cleavage of alpha2delta, voltage-dependent a

124 codes the alphaENaC subunit, was reduced and proteolytic cleavage of alphaENaC decreased.

125 n alters cellular bioenergetics and triggers proteolytic cleavage of AMPKalpha and HIF-1alpha express

126 The work strengthens the understanding of proteolytic cleavage of antibodies expressed in plants a

127 (APP)-cleaving enzyme 1) mediates the first proteolytic cleavage of APP, leading to amyloid beta-pep

128 This interaction promotes a proteolytic cleavage of arid3a and its translocation to

129 CR, an interaction that is inhibited through proteolytic cleavage of AUF1 by the viral proteinase 3CD

130 er and stable incorporation which includes a proteolytic cleavage of BclA after residue 19.

131 Our evidence points to proteolytic cleavage of beta-catenin by calpain as the m

132 uces detachment of existing biofilms through proteolytic cleavage of biofilm matrix components.

133 AP-binding motif of C9b, but did not require proteolytic cleavage of C9b.

134 iredoxin 4 protein expression while reducing proteolytic cleavage of caspase 3 in oligodendrocytes re

135 ntimicrobial peptide LL-37 is generated upon proteolytic cleavage of cathelicidin and limits invading

136 This regulation is mediated by proteolytic cleavage of CD2831 and CD3246 by the zinc me

137 Doxorubicin stimulates proteolytic cleavage of CREB3L1 by Site-1 Protease and S

138 ols the ER-to-Golgi transport and subsequent proteolytic cleavage of CREBH in a circadian manner.

139 In the mammalian host, proteolytic cleavage of CSP regulates the switch to an a

140 Moreover, inhibiting proteolytic cleavage of dystroglycan that occurs in OGD

141 Local proteolytic cleavage of EC JAM-C by neutrophil elastase

142 We suggest a role for the proteolytic cleavage of ENaC by cathepsin B, and we sugg

143 ition 171 (P171G) eliminated a site-specific proteolytic cleavage of FGF21 identified in mice and cyn

144 Fibrin, the product of thrombin's proteolytic cleavage of fibrinogen, provides biophysical

145 HTRA1 promotes IVD degeneration through the proteolytic cleavage of fibronectin and subsequent activ

146 f the MYC oncoprotein family, generated by a proteolytic cleavage of full-length MYC.

147 Proteolytic cleavage of Gag by the viral protease (PR) i

148 undergo a maturation process mediated by the proteolytic cleavage of gag to give rise to the isolated

149 Subsequent proteolytic cleavage of Gag triggers rearrangement of th

150 A treatment of Arabidopsis seedlings induced proteolytic cleavage of GAPC2 and inhibited Arabidopsis

151 he cathepsin-cleavage loop, and prevents the proteolytic cleavage of GP that is required for virus en

152 r cell and that activation of CLEC-2 induces proteolytic cleavage of GPVI and FcgammaRIIa but not of

153 Proteolytic cleavage of Htt into toxic N-terminal fragme

154 csA protein on the bacterial surface through proteolytic cleavage of IcsA.

155 n-like growth factor (IGF) signaling through proteolytic cleavage of IGF-binding proteins (IGFBPs).

156 Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG.

157 The role of the proteolytic cleavage of IL-15Ralpha in this process was

158 romoted calpain activation and increased the proteolytic cleavage of IL-1alpha.

159 Generated by proteolytic cleavage of immunoglobulin, Fab fragments po

160 transfection into 293T cells causes partial proteolytic cleavage of interferon regulatory factor 3 (

161 -1beta transcription and caspase-1-dependent proteolytic cleavage of intracellular pro-IL-1beta.

162 ty of the insulin receptor (IR) requires the proteolytic cleavage of its proform by intra-Golgi furin

163 is produced in pancreatic beta-cells through proteolytic cleavage of its prohormone.

164 Thus, nerve injury promotes proteolytic cleavage of KCC2 through NMDA receptor-calpa

165 ase at the onset of anaphase is triggered by proteolytic cleavage of kleisin.

166 own-regulation of ERK1/2 phosphorylation and proteolytic cleavage of LC3 in tumor cells.

167 ADAM9 inhibition reduces HG-induced proteolytic cleavage of Mer tyrosine receptor kinase (Me

168 Proteolytic cleavage of MerTK at an unidentified site le

169 rate a crucial role for this sheddase in the proteolytic cleavage of MIC by means of silencing and ph

170 Thus, Sap-mediated proteolytic cleavage of Msb2 is required for activation

171 by integrin alphavbeta5 in part by promoting proteolytic cleavage of MUC1 and highlight the ability o

172 downstream signaling proteins, as well as by proteolytic cleavage of multiple substrates.

173 report that synaptic activity induces acute proteolytic cleavage of neuroligin-1 (NLG1), a postsynap

174 ated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK)

175 Increased Cdk5 activity, via proteolytic cleavage of p35 to a p25 fragment by the cal

176 Proteolytic cleavage of PAR(2) reveals a tethered ligand

177 f PAR-2 is a substrate for testisin and that proteolytic cleavage of PAR-2 by recombinant testisin ac

178 Besides inhibiting the proteolytic cleavage of peptide substrates in vitro, it

179 unction of PLTP in the lung and suggest that proteolytic cleavage of PLTP by cathepsin G may enhance

180 oluble HMW-EGF, that HMW-EGF is active, that proteolytic cleavage of pro-EGF first occurs at the C-te

181 vation of the NLRP3-containing inflammasome, proteolytic cleavage of pro-IL-1beta by caspase-1, and r

182 protein containing a CARD (ASC), to catalyze proteolytic cleavage of pro-interleukin-1beta (pro-IL-1b

183 LC3 undergoes two processing steps, the proteolytic cleavage of pro-LC3 and the de-lipidation of

184 ain (ED) binds and activates ErbB4 following proteolytic cleavage of pro-NRG1 precursor protein.

185 Although proteolytic cleavage of recombinant human FGF21 in precl

186 The principle of detection was the specific proteolytic cleavage of redox-tagged peptides by trypsin

187 re reactive phenotype enabled by suppressing proteolytic cleavage of sIL-6R from IL-6R and downregula

188 opment of SIPS through the cathepsin-induced proteolytic cleavage of SIRT1, a mechanism linking cell

189 omain that mediates SltB autoproteolysis and proteolytic cleavage of SltA.

190 It has previously been shown that proteolytic cleavage of SNAP25 by botulinum toxin A redu

191 les as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and t

192 Here, we identify a novel calpain-dependent proteolytic cleavage of talin that results in the releas

193 disrupts the dimeric structure, such as the proteolytic cleavage of TDP-43 within the RRM2 that remo

194 Proteolytic cleavage of the 3L4 was found to abolish tra

195 Following proteolytic cleavage of the A domain, which has been sho

196 N(1801) motif in alpha1C is not required for proteolytic cleavage of the alpha1C C-terminus, and dele

197 lation of residues in alpha1C and C-terminal proteolytic cleavage of the alpha1C subunit.

198 Proteolytic cleavage of the amyloid precursor protein (A

199 on is the activity-dependent endocytosis and proteolytic cleavage of the amyloid precursor protein (A

200 al modification of alpha-tubulin, or whether proteolytic cleavage of the C-terminal tail (CTT) of alp

201 ncrease membrane association, and subsequent proteolytic cleavage of the C-terminus.

202 mediated by CLCA1 does not appear to involve proteolytic cleavage of the channel because a mutant N-t

203 riggers negative feedback regulation through proteolytic cleavage of the channel within the core of t

204 of the P. falciparum CSP, which inhibits the proteolytic cleavage of the CSP, a key requirement for p

205 PCSK7 contributed to the mRNA expression and proteolytic cleavage of the cytokine TGFbeta1a.

206 s that are released from the cell surface by proteolytic cleavage of the cytoskeleton.

207 Proteolytic cleavage of the dynamin-like guanosine triph

208 ard an infectious virion requires sequential proteolytic cleavage of the Gag polyprotein leading to t

209 tween HIV-2 RNA dimerization and the correct proteolytic cleavage of the Gag polyprotein.

210 Activity of ENaC is enhanced by proteolytic cleavage of the gamma-subunit and putative r

211 Furthermore, we observed that proteolytic cleavage of the host extracellular matrix pr

212 Host cell-mediated proteolytic cleavage of the human immunodeficiency virus

213 Here, we provide evidence that proteolytic cleavage of the macrophage efferocytosis rec

214 Proteolytic cleavage of the molecule induced a conformat

215 with the scaffold protein Sav1 and prevents proteolytic cleavage of the Mst1 kinase, resulting in in

216 the 29KE/31KE MA mutant displays a defect in proteolytic cleavage of the murine leukemia virus Env cy

217 s (GPCRs) that are irreversibly activated by proteolytic cleavage of the N terminus, which unmasks a

218 TLR7/8 activation leads to a furin-dependent proteolytic cleavage of the N-terminal part of FcgRIIA,

219 itself does not process VEGF-C, it promotes proteolytic cleavage of the otherwise poorly active 29/3

220 Proteolytic cleavage of the peptide sequence results in

221 eptidase enhancer 1 (Pcolce), which enhances proteolytic cleavage of the procollagen C-terminal prope

222 main (PLP2) that plays a crucial role in the proteolytic cleavage of the PRRSV replicase polyproteins

223 e range of evidence, including resistance to proteolytic cleavage of the putative dimerization portio

224 We postulated that proteolytic cleavage of the reactive center loop produce

225 with a MET therapeutic antibody that induces proteolytic cleavage of the receptor at the cell surface

226 DSL ligands activate Notch by inducing proteolytic cleavage of the receptor ectodomain, an even

227 athways revealed that loss of Casp8 prevents proteolytic cleavage of the receptor-interacting protein

228 bjects also possessed statistically elevated proteolytic cleavage of the reporter relative to normal

229 Low oxygen stimulates proteolytic cleavage of the SREBP homolog Sre1, generati

230 required to induce lung injury in mice, and proteolytic cleavage of the stalk region by MMP-7 reduce

231 s or the phosphorylation, ubiquitination, or proteolytic cleavage of the transcription factor.

232 Thus, the proteolytic cleavage of TLR3 appears to fulfill function

233 response to host DNA is the requirement for proteolytic cleavage of TLR9 in endosomes to generate a

234 Interestingly, ADAM15 mediated the proteolytic cleavage of TRIF.

235 epatic stellate cells with PLS, which caused proteolytic cleavage of TSP1 and decreased activation of

236 coagulation factor VIII (FVIII) accelerates proteolytic cleavage of von Willebrand factor (VWF) by A

237 tivated and degranulated neutrophils inhibit proteolytic cleavage of von Willebrand factor (VWF) by A

238 ot formation, is sufficient for accelerating proteolytic cleavage of VWF by ADAMTS13 under fluid shea

239 t chain of human FVIII (hFVIII-LC) increases proteolytic cleavage of VWF by ADAMTS13 under shear in a

240 us lengths of Abeta peptide are generated by proteolytic cleavages of the amyloid precursor protein (

241 statin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activ

242 c peptide probe requires dual (reductive and proteolytic) cleavages on both disulfide and amide bond

243 hese substrates (e.g. midkine) were prone to proteolytic cleavage only by KLK7 (and not by other skin

244 nnot be easily monitored (e.g. compared with proteolytic cleavage or amino acid phosphorylation); PDI

245 nt to initiate amyloidogenic transition, and proteolytic cleavage or removal of the C-terminal tail o

246 Following proteolytic cleavage, PAR(2) is activated through a teth

247 Differences in proteolytic cleavage patterns and chemical cross-linking

248 y to the peptide WE14, a naturally occurring proteolytic cleavage product from ChgA.

249 loid formation from the precursor peptide (a proteolytic cleavage product of prostatic acid phosphata

250 ncing revealed these smaller fragments to be proteolytic cleavage products and identified a limited n

251 monstrated in vitro, and the accumulation of proteolytic cleavage products in SCA7 patients and mouse

252 Expression of cyclin E proteolytic cleavage products, low-molecular weight cycl

253 n and signaling molecule or via its numerous proteolytic cleavage products.

254 host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link betwee

255 ee of hydrolysis (DH) observed suggests that proteolytic cleavage rapidly occurred within the first 1

256 are an autoantibody subclass that, following proteolytic cleavage, recognize cryptic epitopes exposed

257 ic Abs across epithelia to the mucosa, where proteolytic cleavage releases the ectodomain (secretory

258 embrane Notch receptor undergoes two ordered proteolytic cleavages releasing Notch intracellular doma

259 etalloprotease- and gamma-secretase-mediated proteolytic cleavage, releasing the intracellular protei

260 te immune response to this allergen-mediated proteolytic cleavage represents an ancient type of dange

261 Proteolytic cleavage requires the eight-amino acid Loop1

262 Mlh1-Pms1 DNA binding activity, and in vivo proteolytic cleavage resulted in a complete defect in MM

263 increases open probability of the channel by proteolytic cleavage, resulted in significantly higher c

264 mbrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1).

265 m163S is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin form

266 Mouse and human (h)TLR7 undergo proteolytic cleavage, resulting in the generation of a C

267 rulus in vivo We found evidence that defined proteolytic cleavage results in various proteoforms of i

268 2015, particularly at the hemagglutinin (HA) proteolytic cleavage site (PCS) that can affect virus ac

269 a polypeptides allowed identification of the proteolytic cleavage site of IL-15Ralpha and characteriz

270 The presence of multibasic residues at the proteolytic cleavage site of the fusion (F) protein has

271 m and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA

272 owing that CLCA proteins contain a consensus proteolytic cleavage site recognized by a novel zincin m

273 difficulty via the insertion of a Factor Xa proteolytic cleavage site to acquire the optimal glutama

274 when ligand binding induces exposure of the proteolytic cleavage site, termed S2, within the NRR.

275 fication of 1672 unique protein N-termini or proteolytic cleavage sites from 690 unique proteins.

276 he covalently bound ligands did not mask any proteolytic cleavage sites of pepsin, trypsin or chymotr

277 s of flexible segments that are likely to be proteolytic cleavage sites.

278 an Nrf1 is also ER-associated and subject to proteolytic cleavage, suggesting a conserved mechanism o

279 The sPLA2-X protein is regulated by proteolytic cleavage, suggesting that an inflammatory en

280 -terminal region is unprotected from HDX and proteolytic cleavage, suggesting that it is exposed and

281 The proteolytic cleavage that releases ephrinA1 occurs at th

282 CD44 undergoes sequential proteolytic cleavages that produce an intracytoplasmic d

283 By non-covalent association after proteolytic cleavage, the pro-domains modulate the activ

284 Aap requires proteolytic cleavage to act as an intercellular adhesin.

285 ressed as inactive proenzymes, which undergo proteolytic cleavage to become functional enzymes.

286 expressed near tumor tissue, iRGD encounters proteolytic cleavage to expose the CendR motif that prom

287 that can be activated by caspase-3-dependent proteolytic cleavage to induce dopaminergic neuronal cel

288 Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been imp

289 ind to the anthrax receptor, the consecutive proteolytic cleavage to PA(63), oligomerization, prepore

290 ped chromosomal cohesin complex is opened by proteolytic cleavage to release pairs of sister chromati

291 on the coupling of the sirtuin reaction to a proteolytic cleavage using internally fluorescence-quenc

292 -EEE capsids exhibited a much slower rate of proteolytic cleavage when compared with CTDs of Cp183-WT

293 dding of MIC molecules that are sensitive to proteolytic cleavage, whereas the release of the short M

294 illogenesis in vitro, catalysed by selective proteolytic cleavage, which produces a high yield of gen

295 e CaV1.2 distal C-terminus is susceptible to proteolytic cleavage, which yields a truncated CaV1.2 su

296 e chaperone protein GRP78, through specific, proteolytic cleavage with the immunotoxin EGF-SubA repre

297 arasite surface and subsequently released by proteolytic cleavage within its transmembrane domain.

298 In addition, a secondary proteolytic cleavage within the membrane-associated SIRP

299 These peptides are produced by sequential proteolytic cleavage within the transmembrane helix of t

300 lusion, human kidney gammaENaC is subject to proteolytic cleavage, yielding fragments compatible with