ライフサイエンスコーパス: proteolytic degradation

1 portant role in the regulation of FXIIIA via proteolytic degradation.

2 of exponential phase RNase R and subsequent proteolytic degradation.

3 s with extra rigidity and resistance against proteolytic degradation.

4 r channel them into alternative pathways for proteolytic degradation.

5 " them, in vivo, for regulatory roles beyond proteolytic degradation.

6 iciently unnatural that these polymers evade proteolytic degradation.

7 e, blood-brain barrier transport, and direct proteolytic degradation.

8 RASSF2-dependent protection of MST2 against proteolytic degradation.

9 ity to reduce FXIIIA levels and function via proteolytic degradation.

10 stability of StAR but offers protection from proteolytic degradation.

11 ulate, suggesting that OMA1 is attenuated by proteolytic degradation.

12 horylation, ubiquitination, and, ultimately, proteolytic degradation.

13 he transport of alpha-syn to the vacuole for proteolytic degradation.

14 gnized strategy to improve resistance toward proteolytic degradation.

15 the susceptibility of alpha/beta-peptides to proteolytic degradation.

16 and prevents dTRAF2 from ubiquitin-mediated proteolytic degradation.

17 nner membrane and to protect each other from proteolytic degradation.

18 renders PAI-1 vulnerable to plasmin-mediated proteolytic degradation.

19 cause it targets NEDD8 to the proteasome for proteolytic degradation.

20 xin secretion and not attributable to solely proteolytic degradation.

21 lar ErbB3 levels by marking the receptor for proteolytic degradation.

22 1 receptor domain of TLRs and promotes their proteolytic degradation.

23 poxia and VEGF can downregulate PEDF through proteolytic degradation.

24 th activates Chk1 and marks this protein for proteolytic degradation.

25 s, chemokine function is mostly regulated by proteolytic degradation.

26 s to the amino-terminus is essential for the proteolytic degradation.

27 ch more mechanically stable and resistant to proteolytic degradation.

28 otection of the enzyme from inactivation and proteolytic degradation.

29 1 stimulatory factor is susceptible to SpeB proteolytic degradation.

30 itionally, they protect protein samples from proteolytic degradation.

31 his domain was thermally stable and resisted proteolytic degradation.

32 ress to [4Fe-4S](2+) cluster disassembly and proteolytic degradation.

33 and it does not appear to be associated with proteolytic degradation.

34 tion of a 10-amino-acid tag that signals for proteolytic degradation.

35 capacity of FGF-2 and also protects it from proteolytic degradation.

36 brane receptors and ligands to lysosomes for proteolytic degradation.

37 from increased sensitivity to cathepsin-like proteolytic degradation.

38 subsequently induced its ubiquitination and proteolytic degradation.

39 y in the cytoplasm possibly due to increased proteolytic degradation.

40 n be removed by this mechanism without prior proteolytic degradation.

41 ic properties but an enhanced sensitivity to proteolytic degradation.

42 lac promoter/operator are crucial to reduce proteolytic degradation.

43 inked network that is much more resistant to proteolytic degradation.

44 monomers with extreme resistance to heat and proteolytic degradation.

45 DR corneas may occur because of an increased proteolytic degradation.

46 ormal proteins, targeting these proteins for proteolytic degradation.

47 ited a significantly increased resistance to proteolytic degradation.

48 , and protects the polypeptide backbone from proteolytic degradation.

49 gainst thermal and chemical denaturation and proteolytic degradation.

50 ass of antimicrobial agents are resistant to proteolytic degradation.

51 tion factor VIII (FVIII), protecting it from proteolytic degradation.

52 elevated temperature and humidity) and from proteolytic degradation.

53 e increased in obesity, when SirT1 undergoes proteolytic degradation.

54 through active transport, and resistance to proteolytic degradation.

55 aberrant and toxic proteins for refolding or proteolytic degradation.

56 urthermore, DnaG is prone to aggregation and proteolytic degradation.

57 amino acids (x and k), and was stable toward proteolytic degradation.

58 displayed a high stability against heat and proteolytic degradation.

59 terface and predicts their susceptibility to proteolytic degradation.

60 silencing by targeting an unknown factor for proteolytic degradation.

61 ting Factors (PIFs), which induces rapid PIF proteolytic degradation.

62 dulated by phosphorylation and site-specific proteolytic degradation.

63 -1 in hindlimb ischemia may be challenged by proteolytic degradation.

64 nstrated that the matrix protected FGF2 from proteolytic degradations.

65 Functional classes include defects in (1) proteolytic degradation, (2) ubiquitin signaling, and (3

66 l tissue on digestion, spectral evidence for proteolytic degradation after gel separation, and identi

67 association was found between sensitivity to proteolytic degradation and aggregation profiles.

68 this subcomplex protects each component from proteolytic degradation and also allows their coregulati

69 Short half-lives due to rapid proteolytic degradation and an inability to cross cell m

70 eliminated from the cytoplasmic membrane by proteolytic degradation and argue against a model in whi

71 n by Akt through mutagenesis accelerates its proteolytic degradation and chromatin condensation.

72 le the problems of inclusion body formation, proteolytic degradation and disulfide bond generation th

73 of cyclotides against chemical, thermal, or proteolytic degradation and has sparked growing interest

74 a key role in protecting the A subunit from proteolytic degradation and in delivering the enzymatic

75 sport pathways allude to their importance of proteolytic degradation and ion transport in maintaining

76 at the modified motif per se is resistant to proteolytic degradation and is a candidate antiinfective

77 use like most peptides, it is susceptible to proteolytic degradation and is challenging to synthesize

78 ort half-life, its susceptibility to in vivo proteolytic degradation and its propensity to in vitro a

79 MDA-MB-231 cells capable of proteolytic degradation and mesenchymal motion, invaded

80 Here, we used proteolytic degradation and mutational analysis to local

81 decreased transporter activity, followed by proteolytic degradation and possibly internalization of

82 These inhibitors resisted proteolytic degradation and rapidly inactivated PR3 in b

83 nt beta-glucuronidase and is associated with proteolytic degradation and reduced surface NaPi-2a.

84 The complementarity of fast, specific proteolytic degradation and slower, broad transcriptomic

85 bers, phyA is subject to rapid light-induced proteolytic degradation and so accumulates to relatively

86 opper), polypeptide half-life, resistance to proteolytic degradation and solubility, in an effort to

87 knowledge of tissue IGF-1 regulation through proteolytic degradation and suggest that chymase inhibit

88 1P was again able to protect Rubisco against proteolytic degradation and the consequent irreversible

89 estered intracellular cargo to lysosomes for proteolytic degradation and thereby maintains cellular h

90 y unstable proteins that were susceptible to proteolytic degradation and three (H94A, I101A, and N102

91 it was enzymatically active but sensitive to proteolytic degradation and unable to bind gangliosides,

92 results in endoplasmic reticulum retention, proteolytic degradation, and absence of adenosine 3',5'-

93 ng ligands, susceptibility to cell-triggered proteolytic degradation, and remodeling.

94 uorescent form, the susceptibility of GFP to proteolytic degradation, and the growth rate of the bact

95 accumulates due to a decrease in the rate of proteolytic degradation, and the resulting HIF-1alpha-HI

96 mulates because of a decrease in the rate of proteolytic degradation, and the resulting HIF1alpha-HIF

97 stabilize p53 protein through inhibition of proteolytic degradation, and this increase in p53 protei

98 ved that regulation of transcript clearance, proteolytic degradation, and translational rate contribu

99 tides") manifest decreased susceptibility to proteolytic degradation, and when properly designed thes

100 al class I binding oligopeptides that escape proteolytic degradation are potent crosspriming agents.

101 pecifically target either STAT1 or STAT2 for proteolytic degradation as a countermeasure for evading

102 o sequester SLBP in vivo, protecting it from proteolytic degradation as an inactive heterotetramer, o

103 ting occurs later and results from increased proteolytic degradation as well as decreased protein syn

104 ity of empty class II molecules, and thus to proteolytic degradation before export to the surface of

105 t and abrogate Bak function by promoting its proteolytic degradation both in vitro and in regenerated

106 active pool of PI4KIIbeta, shielding it from proteolytic degradation but also sequestering it to the

107 Gln-333 is geographically close to a site of proteolytic degradation but not to activator, cofactor,

108 The down-regulation of CXCR4 was not due to proteolytic degradation but rather to transcriptional re

109 ha subunits were typically very sensitive to proteolytic degradation, but alphaT*(R238E) exhibited a

110 core complex, in the presence of O(2), from proteolytic degradation by a serine metalloprotease.

111 activation requires autophosphorylation and proteolytic degradation by caspases.

112 Proteolytic degradation by collagenase IV was observed i

113 fied elastin and significantly decreased its proteolytic degradation by elastolytic enzymes belonging

114 Prolonged activation of MORs promotes their proteolytic degradation by endocytic trafficking to lyso

115 and rendered the protein fully resistant to proteolytic degradation by gingipains.

116 site shields the S100A9 C-terminal tail from proteolytic degradation by proteinase K.

117 the outer membrane vesicles is accessible to proteolytic degradation by proteinase K.

118 in untransformed melanocytes are targeted to proteolytic degradation by the 26 S proteasome due to re

119 re the MOG40-48 epitope is protected against proteolytic degradation by the endolysosomal serine prot

120 tion of Met144 has little effect on rates of proteolytic degradation by the proteasome/Hsp90 or the s

121 ctor-alpha (HIFalpha), which is targeted for proteolytic degradation by the VHL gene product pVHL.

122 ransfected cells normally, and none suffered proteolytic degradation by trypsin.

123 itic joints occur concurrently with enhanced proteolytic degradation by up-regulated cathepsin B and

124 mic equilibrium between matrix synthesis and proteolytic degradation, by counteracting deposition of

125 Although this proteolytic degradation can be blocked by the protease i

126 stable, and exhibits increased resistance to proteolytic degradation compared with the linear peptide

127 ects of proteasome inhibition indicated that proteolytic degradation controls agonist efficacy by set

128 port that the loss of CFA activity is due to proteolytic degradation dependent on expression of the h

129 This proteolytic degradation derepresses transcription of all

130 Mutations disrupting this signal blunted proteolytic degradation downstream of E3 ubiquitin ligas

131 for viral RNA synthesis, was stable against proteolytic degradation during expression.

132 Exogenously added peptides are subject to proteolytic degradation for extended periods of time bef

133 phagosome must then balance microbicidal and proteolytic degradation functions with the generation of

134 Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely

135 -crystallin showed a significant increase in proteolytic degradation in both lens fiber and reticuloc

136 aposin C is required for GCase resistance to proteolytic degradation in the cell.

137 ion domain C terminus that is protected from proteolytic degradation in the context of the proteolipo

138 its nuclear translocation and preventing its proteolytic degradation in the cytoplasm.

139 pal E3 ubiquitin ligase responsible for Set8 proteolytic degradation in the S phase of the cell cycle

140 on across the inner membrane, and preventing proteolytic degradation, incorrect disulfide-bond format

141 Clearance of fibrin through proteolytic degradation is a critical step of matrix rem

142 Protein proteolytic degradation is an essential component to pro

143 Furthermore, TRIF-induced proteolytic degradation is extended to TLR3, TLR6, TLR7,

144 of the biofilms to multiple antibiotics and proteolytic degradation is significantly affected.

145 bility of biologically active peptides where proteolytic degradation limits therapeutic value.

146 Proteolytic degradation may contribute to the nonrespons

147 s stabilization of certain turns and against proteolytic degradation, methods to introduce D-stereoce

148 ive regulators (e.g., PIFs) by light-induced proteolytic degradation might be sufficient to promote p

149 alpha- (mI-kappa B), which does not undergo proteolytic degradation, NF-kappa B remains in the cytos

150 ion enzymes, alleviation is partially due to proteolytic degradation of a subunit of the enzyme.

151 demonstrate that antibody fragment mediated proteolytic degradation of Abeta peptide can be a potent

152 otropic glutamate receptors, consistent with proteolytic degradation of all three Sp1-related factors

153 Proteolytic degradation of an HsEg5.NSC622124 complex re

154 pairs activity and eventually results in the proteolytic degradation of at least one of the core prot

155 d" (1, a recently described inhibitor of the proteolytic degradation of Axin) stimulated cardiomyogen

156 ecyl sulfate gel electrophoresis detected no proteolytic degradation of biotinylated IgG.

157 ds is both necessary and sufficient to cause proteolytic degradation of both ERK2 and green fluoresce

158 tment with calpain inhibitor I prevented the proteolytic degradation of both GFAP and alpha-fodrin in

159 In addition, we analyzed photoinduced proteolytic degradation of both types of CRYs in vivo in

160 6 and E7 to antagonize BRCA1 did not involve proteolytic degradation of BRCA1.

161 tly overexpressed in PCa, is involved in the proteolytic degradation of BRCA2 in PCa cells, suggestin

162 -MMP by glioma and fibrosarcoma cells led to proteolytic degradation of cell surface tissue transglut

163 ent endopeptidases which are involved in the proteolytic degradation of components of the extracellul

164 ation has been ascribed to the following: 1) proteolytic degradation of corneodesmosomes (CDs); 2) di

165 nt focal ischemia may be mediated by reduced proteolytic degradation of critical blood-brain barrier

166 on injury may directly result, in part, from proteolytic degradation of cTnI, resulting in alteration

167 Progressive proteolytic degradation of cutaneous elastic fibers, tha

168 These data suggest that proteolytic degradation of CXCL12 is characteristic of b

169 that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibit

170 ese results suggest that CUL-4A mediates the proteolytic degradation of DDB2 and that this degradatio

171 IL-4 treatment led to proteolytic degradation of dimethylarginine dimethylamin

172 These data suggest that proteolytic degradation of DNA-protein cross-links may b

173 ans invades mucosal tissues by promoting the proteolytic degradation of E-cadherin in epithelial adhe

174 However, the proteolytic degradation of eIF4G alone by the human rhin

175 inhibit either ligand-induced endocytosis or proteolytic degradation of endocytosed receptors.

176 roles in the regulation of the activity and proteolytic degradation of enzymes involved in primary c

177 Internalization and proteolytic degradation of epidermal growth factor (EGF)

178 that EA and TA may be useful for preventing proteolytic degradation of existing dermal elastic fiber

179 giogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intr

180 is characterized by chronic inflammation and proteolytic degradation of extracellular matrix.

181 gical and pathological processes through the proteolytic degradation of extracellular or transmembran

182 originating from fibrillar collagen, and the proteolytic degradation of fibrils is a mechanism allowi

183 Significantly, we found that upon proteolytic degradation of fluorescently labeled sAbeta,

184 Aided by the model, we also quantified the proteolytic degradation of GFP[AAV], GFP[ASV], and GFP[L

185 n that growth factor stimulation induces the proteolytic degradation of hSpry2 by stimulating tyrosin

186 An enhanced proteolytic degradation of hSpry2 is also observed in re

187 F-kappa B and diminished phosphorylation and proteolytic degradation of I kappa B-alpha.

188 first study to demonstrate the extracellular proteolytic degradation of IFN-gamma by ADAM17.

189 hat secretory component does not prevent the proteolytic degradation of IgA1 by IgA1 protease.

190 IGFBP-5 to bind IGF-I, but it increased the proteolytic degradation of IGFBP-5.

191 sphorylation, ubiquitination, and ultimately proteolytic degradation of IkappaB, which frees NF-kappa

192 cation of NF-kappaB, and phosphorylation and proteolytic degradation of IkappaBalpha in macrophages.

193 paBalpha kinase-dependent phosphorylation or proteolytic degradation of IkappaBalpha.

194 During this process, cells initiate proteolytic degradation of internalized protein Ags into

195 ature cCF10 peptide could be formed from the proteolytic degradation of its signal peptide.

196 It is thought that irrevocable proteolytic degradation of key cell-cycle regulators mak

197 Proteolytic degradation of mitotic regulatory proteins f

198 that phosphorylation at Ser-8 inhibited the proteolytic degradation of monomeric Abeta by the insuli

199 AO1 on PIA-AMV was correlated with increased proteolytic degradation of MucA, and required envelope p

200 Proteolytic degradation of MYCN protein is regulated in

201 an Aurora A conformation-specific effect on proteolytic degradation of MYCN, rather than simple nano

202 eptin, were found to effectively inhibit the proteolytic degradation of nNOS.

203 tem with geldanamycin, leads to the enhanced proteolytic degradation of nNOS.

204 er cells induced targeted ubiquitination and proteolytic degradation of nuclear and cytoplasmic free

205 t not RTK agonist-induced nuclear export and proteolytic degradation of p21Cip1 in HASMC proliferatio

206 s was because reduced PI3-K activity lead to proteolytic degradation of p27.

207 human papillomaviruses (HPVs), which mediate proteolytic degradation of p53, the E6 protein of cutane

208 apoptosis and controls the caspase-dependent proteolytic degradation of PKC isotypes.

209 Proteolytic degradation of procaspase-3 was observed in

210 n shown to play a role in assisting with the proteolytic degradation of proteins involved in competen

211 significantly before the onset of detectable proteolytic degradation of receptors ( approximately 60

212 ed geldanamycin-activated ubiquitination and proteolytic degradation of RIP1.

213 Proteolytic degradation of RPT6 was dependent on the loc

214 simple, fast, reliable method for evaluating proteolytic degradation of sarcoplasmic proteins during

215 This effect is not due to direct proteolytic degradation of secreted pheromone by the pro

216 e effects observed are modulated through the proteolytic degradation of several cytoplasmic proteins

217 transcriptional program, and light-regulated proteolytic degradation of several photoreceptors and si

218 Proteolytic degradation of Smad1 and Cbfa1 is proteasome

219 otein ligase and enhances ubiquitination and proteolytic degradation of some TLRs.

220 crosis, a process associated with additional proteolytic degradation of specific autoantigens.

221 that is implemented at least partly through proteolytic degradation of specific signaling proteins.

222 ata support a role for Tribbles in promoting proteolytic degradation of String/Cdc25, a key regulator

223 s loop in transformed cells was dependent on proteolytic degradation of suppressor of cytokine signal

224 type I enzymes, this control is mediated by proteolytic degradation of that subunit of the complex w

225 Degrons within AD1 do not promote proteolytic degradation of the 120-kDa Nrf1 glycoprotein

226 erivative of DM1 is subsequently released by proteolytic degradation of the antibody moiety within th

227 ransition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichi

228 Up-regulation of MMP activity, favoring proteolytic degradation of the basement membrane and ext

229 pericytes contribute to rapid and localized proteolytic degradation of the BBB during cerebral ische

230 This is in part owing to proteolytic degradation of the BH3-only family of pro-ap

231 omplex with the F-box protein Slimb mediates proteolytic degradation of the centrosomal regulatory ki

232 Our data suggest that, if coupled with proteolytic degradation of the crosslinked protein, the

233 vations indicate for the first time that the proteolytic degradation of the ECM by MMPs is a necessar

234 The second step is proteolytic degradation of the ECM, led by advancing pro

235 munoreactivity was assessed before and after proteolytic degradation of the ELP partner.

236 talytic inactivation, dephosphorylation, and proteolytic degradation of the enzyme.

237 th high affinity and specificity, leading to proteolytic degradation of the ERG protein.

238 Postgermination proteolytic degradation of the essential ABI5 transcript

239 A protease and is not coupled to 2A-mediated proteolytic degradation of the eukaryotic initiation fac

240 Proteolytic degradation of the extracellular matrix (ECM

241 eceptor (uPAR) provides a rendezvous between proteolytic degradation of the extracellular matrix and

242 Because proteolytic degradation of the extracellular matrix is a

243 atic activities suggests a mechanism of host proteolytic degradation of the extracellular matrix resu

244 n activator inhibitor-1, an inhibitor of the proteolytic degradation of the extracellular matrix.

245 bition of Rho strongly inhibited Src-induced proteolytic degradation of the extracellular matrix.

246 nt endopeptidases that play crucial roles in proteolytic degradation of the extracellular matrix.

247 ue remodeling is disturbed,(3) and excessive proteolytic degradation of the joint matrices leads to j

248 esions, and occurred even with inhibition of proteolytic degradation of the matrix.

249 slation process of the oxidized mRNA and the proteolytic degradation of the modified full-length luci

250 om molecular nanofibrils and accelerates the proteolytic degradation of the molecular nanofibrils.

251 Proteolytic degradation of the murine cardiac mitochondr

252 products plus dityrosine was only seen after proteolytic degradation of the oxidatively modified hemo

253 t cryptochrome photoreaction that results in proteolytic degradation of the photopigment.

254 Proteolytic degradation of the provisional fibrin matrix

255 naling is perturbed in the CF airways due to proteolytic degradation of the receptor.

256 dies showed that overexpression of E7 caused proteolytic degradation of the tumor suppressor Rb.

257 cycling-defective mutant B2ARs also enhanced proteolytic degradation of the wild-type B2AR after agon

258 abrogated upon light exposure by phy-induced proteolytic degradation of these PIFs, allowing the init

259 and model phagosomes differed, as a discrete proteolytic degradation of this SNARE was detected on my

260 role in TLR5-elicited responses by inducing proteolytic degradation of TLR5.

261 ombination of transcriptional regulation and proteolytic degradation of TrfA by ClpCP.

262 he binding of cells to fibronectin (Fn), the proteolytic degradation of tTG by MT1-MMP specifically s

263 In contrast, the proteolytic degradation of tTG stimulated migration of c

264 ons on the mechanical stability and in vitro proteolytic degradation of type I collagen.

265 We report that DUX4-triggered proteolytic degradation of UPF1, a central component of

266 ve mechanisms of graft injury with roles for proteolytic degradation of uromodulin (UMOD) and several

267 eration of the blood-retinal barrier through proteolytic degradation of VE-cadherin.

268 iabetes contributes to BRB breakdown through proteolytic degradation of VE-cadherin.

269 ovirus disassembly is the cathepsin-mediated proteolytic degradation of viral outer capsid protein si

270 into the rate-limiting phosphorylation (and proteolytic degradation) of IkappaBalpha, the inhibitory

271 However, their susceptibility to proteolytic degradation often limits their utility in th

272 the absence of Mzm1, Rip1 is prone to either proteolytic degradation or temperature-induced aggregati

273 The mechanism of this selective proteolytic degradation, or in essence how the nNOS beco

274 N-Formyl peptides are derived from proteolytic degradation/processing of bacterial and mito

275 Moreover, we observed distinct proteolytic degradation products for hcTnT and mcTnT.

276 e AR and that detection of the corresponding proteolytic degradation products in urine provides a non

277 ofolate, are direct targets of As2O3-induced proteolytic degradation, providing a mechanism for arsen

278 way by geldanamycin, an effect partly due to proteolytic degradation rather than disulfide reduction.

279 Proteolytic degradation reduces the levels of unfolded a

280 homologue shows substantial protection from proteolytic degradation relative to the Bim BH3 alpha-pe

281 itial autocleavage of IrvR and exposure of a proteolytic degradation sequence followed by Clp-depende

282 injection, optoporated peptide showed little proteolytic degradation, suggesting that the cells were

283 lpha/beta-peptide is far less susceptible to proteolytic degradation than is an analogous alpha-pepti

284 TTSS-dependent effectors are subject to the proteolytic degradation that appears to be rate-limiting

285 Phosphorylation of I kappa B targets it for proteolytic degradation, thereby releasing NF-kappa B fo

286 that redirects IRF3 to the endolysosome for proteolytic degradation, thus allowing HIV to avoid the

287 cell stimulation, our findings indicate that proteolytic degradation tightly couples RGS2 transcripti

288 basement membrane is rendered distensible by proteolytic degradation to allow it to be moved and remo

289 e ligand density, mechanical properties, and proteolytic degradation to study the impact of ECM prope

290 results suggest that ToxT protein undergoes proteolytic degradation to terminate virulence gene expr

291 ild and harsh acidic conditions, storage and proteolytic degradation--unlike native bFGF.

292 that these subunits are protected from rapid proteolytic degradation until they are assembled in the

293 A-crystallins were labeled with (125)I, and proteolytic degradation was determined using both lens f

294 aC-crystallins were labeled with (125)I, and proteolytic degradation was determined using both lens f

295 lipid binding, chaperone-like function, and proteolytic degradation were systematically examined by

296 Balpha by phosphorylation, ubiquination, and proteolytic degradation, which allows NF-kappaB to trans

297 P49 are phosphorylated proteins that undergo proteolytic degradation with fiber cell age; however, th

298 biospecific cell adhesion and cell-mediated proteolytic degradation with independently adjustable ma

299 LEDGF from heat, acid-base deactivation, and proteolytic degradation with trypsin and chymotrypsin an

300 The internalized protein undergoes proteolytic degradation, yielding amino acids including