ライフサイエンスコーパス: proteolytic enzyme

1 based classification of peptidases (i.e. all proteolytic enzymes).

2 al metastatic effect of this multifunctional proteolytic enzyme.

3 examined the role of cathepsin B as a model proteolytic enzyme.

4 prompting speculation that it functions as a proteolytic enzyme.

5 f FAK, with no marked increases in genes for proteolytic enzymes.

6 ) phosphorylation and in gene expression for proteolytic enzymes.

7 r significantly reduced upon hydrolysis with proteolytic enzymes.

8 cyte lysate as sources of ubiquitinating and proteolytic enzymes.

9 ion, up-regulation, and secretion of various proteolytic enzymes.

10 cyte lysate as sources of ubiquitinating and proteolytic enzymes.

11 3) up-regulate a group of genes that include proteolytic enzymes.

12 sms have evolved to regulate the function of proteolytic enzymes.

13 gammaRIII-deficient neutrophils, to secrete proteolytic enzymes.

14 ot-based enzymatic probes in the presence of proteolytic enzymes.

15 he protein requires cleavage by two distinct proteolytic enzymes.

16 through the release of cathepsin B and other proteolytic enzymes.

17 e particularly susceptible to degradation by proteolytic enzymes.

18 g force in the evolution of parasite-derived proteolytic enzymes.

19 nd proteins is resistant to cleavage by most proteolytic enzymes.

20 been developed that degrade as cells secrete proteolytic enzymes.

21 d found to produce a range of glycosidic and proteolytic enzymes.

22 enced by matrix metalloproteinases and other proteolytic enzymes.

23 to an immobilized Ab and then digested with proteolytic enzymes.

24 rointestinal environments in presence of the proteolytic enzymes.

25 eta, a cytokine that can induce secretion of proteolytic enzymes.

26 interstitial tissues by mobilizing undefined proteolytic enzymes.

27 exploring molecular recognition elements in proteolytic enzymes.

28 kinetics were accelerated in the presence of proteolytic enzymes.

29 hether SCCA2 inhibited a different family of proteolytic enzymes.

30 an important opsonin (iC3b) are destroyed by proteolytic enzymes.

31 turing agents and aqueous buffers containing proteolytic enzymes.

32 ll basement membrane can both be affected by proteolytic enzymes.

33 eases belonging to five catalytic classes of proteolytic enzymes.

34 ilatory agents, antilymphogenic therapy, and proteolytic enzymes.

35 gical macromolecules, including proteins and proteolytic enzymes.

36 ection of the protein against degradation by proteolytic enzymes.

37 and selective reagents for a wide variety of proteolytic enzymes.

38 e caused by activation of calpain or caspase proteolytic enzymes.

39 itin was shown to be relatively resistant to proteolytic enzymes.

40 ling during cervical ripening via release of proteolytic enzymes.

41 isease (AD), is degraded by a diverse set of proteolytic enzymes.

42 Bacteria produce a range of proteolytic enzymes.

43 By targeting the actions of these proteolytic enzymes, a more controlled and physiological

44 A number of proteolytic enzymes activate pro-MMP-9 in vitro, but the

45 levels for myofibrillar proteins, increased proteolytic enzyme activities, and a lower myosin/actin

46 speculate that AgrB is a novel protein with proteolytic enzyme activity and a transporter facilitati

47 We suggest, therefore, that proteolytic enzyme activity contributes to loss of exocr

48 Proteolytic enzyme activity in lipid-rich atheroma may p

49 content due in part to less fluid, aberrant proteolytic enzyme activity, decline in amylase activity

50 ressed proinflammatory responses, as well as proteolytic enzyme activity, induced by ligature.

51 ed to construct sensing assemblies to detect proteolytic enzyme activity.

52 arch industry was hydrolyzed with commercial proteolytic enzymes (Alcalase, Neutrase, Flavourzyme) an

53 ocessing seed storage protein and that other proteolytic enzymes also can process storage proteins in

54 Using trypsin as the sole proteolytic enzyme and data from a single injection per

55 trate a role for a leucine zipper motif in a proteolytic enzyme and suggest that leucine zipper motif

56 in-kinin system (KKS) comprises a cascade of proteolytic enzymes and biogenic peptides that regulate

57 tion by stimulating the expression of matrix proteolytic enzymes and by downregulating the deposition

58 nd heterotypic adhesion while also secreting proteolytic enzymes and experiencing a haptotactic gradi

59 This method is compatible with a range of proteolytic enzymes and fragmentation methods, and shoul

60 ulating the bioavailability of extracellular proteolytic enzymes and growth factors.

61 In addition, the release of proteolytic enzymes and inhibitors is imbalanced.

62 Proteins were digested with proteolytic enzymes and peptides masses determined by ma

63 mine further the expression of a spectrum of proteolytic enzymes and protease inhibitors.

64 Fab and abeta(1-40) complex was treated with proteolytic enzymes and the digested complexes were dire

65 hich requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors.

66 believed to result from an imbalance between proteolytic enzymes and their inhibitors.

67 Characterization of proteolytic enzymes and their substrates presents a form

68 idolysis assay is readily adaptable to other proteolytic enzymes and their substrates.

69 The terms "proteolytic enzyme" and "peptidase" have been treated as

70 Peptidases (proteolytic enzymes) and their natural, protein inhibito

71 olved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthes

72 hat now implicates cytokines and chemokines, proteolytic enzymes, and oxidants in the inflammatory ca

73 of accurate mass data, expected cleavages by proteolytic enzymes, and postsource decay sequencing all

74 of nonionic detergents, reducing agents, and proteolytic enzymes, and successive products of the reac

75 These proteolytic enzymes are also the first in which the nucl

76 Proteolytic enzymes are essential for initiation of the

77 In this technique, samples containing proteolytic enzymes are first resolved in nonreducing SD

78 disintegrin and metalloproteinase) family of proteolytic enzymes are implicated in the processing of

79 Proteolytic enzymes are key signaling molecules in both

80 Proteolytic enzymes are known to be associated with deve

81 Proteolytic enzymes are necessary for the mineralization

82 ases that disrupt host tissue and that these proteolytic enzymes are regulated by multiple transcript

83 Proteolytic enzymes are required to mediate tumor cell i

84 Peptidases (proteolytic enzymes) are of great relevance to biology,

85 n be used to dissect the biological roles of proteolytic enzymes as well as to develop diagnostic and

86 ix-degrading metalloproteinases, a family of proteolytic enzymes, as mediators of collagen damage in

87 tated by the catalytic activities of granule proteolytic enzymes, assists in the targeting (storage)

88 teine proteases (PLCPs) are a large class of proteolytic enzymes associated with development, immunit

89 been developed for detecting the activity of proteolytic enzymes based on fluorescent conjugated poly

90 enzymes with the milk proteins and the main proteolytic enzymes becomes important in determining the

91 hordin are in turn regulated by the secreted proteolytic enzymes BMP1 and Xolloid.

92 Zymography detects and characterizes proteolytic enzymes by electrophoresis of protease-conta

93 atially heterogeneous biochemical network of proteolytic enzymes called blood coagulation.

94 d/or the regulation of a group of endogenous proteolytic enzymes called kallikreins.

95 Cleavage is suppressed by inhibitors of the proteolytic enzyme, calpain I.

96 Proteolytic enzyme, calpain, is a potential candidate fo

97 -/-) mice is associated with activation of a proteolytic enzyme, Calpain-1.

98 e release of cytochrome c, which activates a proteolytic enzyme cascade, resulting in specific nuclea

99 tein present in platelets but also regulates proteolytic enzyme cascades, including the blood coagula

100 cl-micelles was observed in the presence of proteolytic enzymes (cathepsin B).

101 -40% to 86-89%, respectively with increasing proteolytic enzyme concentration.

102 ecreted virulence factors, including various proteolytic enzymes, contribute to the establishment and

103 This steroidal modulation of proteolytic enzymes could help to explain why pregnancy

104 modified peptides, to improve resistance to proteolytic enzyme degradation, and to modulate physico-

105 hat the CPZ-1 enzyme functions directly as a proteolytic enzyme degrading cuticular proteins before e

106 tion, and augments superoxide production and proteolytic enzyme degranulation.

107 Treatment of the pigmented cells with proteolytic enzymes, denaturant, and hot concentrated ac

108 Additionally, inhibitors of these proteolytic enzymes did not affect the biological activi

109 Because the proteolytic enzyme dispase dissociates tissues, the hypo

110 ing those that target inflammatory cells and proteolytic enzymes (eg, integrin alphavbeta3 and matrix

111 acologically active member of the sulfhydryl proteolytic enzyme family, obtained from Ananas comosus

112 The first structure of an ant proteolytic enzyme, fire ant chymotrypsin, was determine

113 Matrix metalloproteinase-9 (MMP-9), a proteolytic enzyme for matrix proteins, chemokines and c

114 y show that cathepsin L functions as a major proteolytic enzyme for the production of POMC-derived pe

115 ng phage display have been widely applied to proteolytic enzymes for substrate selection and optimiza

116 cera can be used as an alternative source of proteolytic enzymes for the effective tenderising of mea

117 icular the roles of excitotoxic amino acids, proteolytic enzymes, free radicals, nitric oxide, and le

118 shown that there is an interesting group of proteolytic enzymes from carnivorous pitcher plants of t

119 The proteolytic enzymes generating short N-terminal fragment

120 of inhibitors with enhanced potency against proteolytic enzymes has many applications for the treatm

121 se" have been treated as synonymous, and all proteolytic enzymes have been considered to be hydrolase

122 For a long time, proteolytic enzymes have been employed as key tools of i

123 Proteolytic enzymes have been proposed to play a role in

124 ticular attention focuses on the impact that proteolytic enzymes have on the tumour's progression.

125 Proteolytic enzymes have shown efficacy in cancer therap

126 t following apoptosis, the caspase family of proteolytic enzymes have the potential to generate immun

127 n CcI3, with more esterolytic, lipolytic and proteolytic enzymes having signal peptides.

128 Cathepsin E (Cath E) is a proteolytic enzyme highly expressed in PDAC.

129 phosphoproteome that uses endo-Lys C as the proteolytic enzyme, immobilized metal affinity chromatog

130 oteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remod

131 During this process Ce-CPL-1 may act as a proteolytic enzyme in the processing/degradation of cuti

132 a multigene family of 56 subtilisin-related proteolytic enzymes in Arabidopsis thaliana.

133 roviding information about the activities of proteolytic enzymes in blood, which may be correlated wi

134 The abundance of proteolytic enzymes in cancer cells makes it difficult t

135 in the levels of bacterial and host-derived proteolytic enzymes in oral inflammatory exudates.

136 h of more recent developments of the role of proteolytic enzymes in physiological regulation and an o

137 proaches to study activity and substrates of proteolytic enzymes in relevant biological models, both

138 extracellular matrix barriers by mobilizing proteolytic enzymes in response to epidermal growth fact

139 ocalize various members of the MMP family of proteolytic enzymes in the Bruch's-choroid complex.

140 To assess the role of inflammatory cells and proteolytic enzymes in the development of chronic allogr

141 ges of the parasite that would be exposed to proteolytic enzymes in the digestive tract of the host.

142 e proteinases were the predominant digestive proteolytic enzymes in the guts of these insects at this

143 cs of matrix gene expression and activity of proteolytic enzymes in the lesion were evaluated.

144 The presence of proteolytic enzymes in the OMV did not contribute to cap

145 The immobilized HSA was digested by various proteolytic enzymes in the presence of normal water, whi

146 gnificantly lower and less complex levels of proteolytic enzymes, in comparison with leaf extracts, w

147 rointestinal digestion (SGID) performed with proteolytic enzymes, in vitro.

148 selectivity for HRV-14 3CP compared to other proteolytic enzymes, including chymotrypsin and cathepsi

149 Proteolytic enzymes, including fibroblast collagenase, h

150 60-kDa protein was stable in the presence of proteolytic enzyme inhibitors but was gradually converte

151 were stored in artificial saliva containing proteolytic enzyme inhibitors, or pure mineral oil.

152 g, to more subtle effects on the activity of proteolytic enzymes involved in antigen processing.

153 In our search for novel proteolytic enzymes involved in MHC class I (MHC-I) pres

154 Degradation of the extracellular matrix by proteolytic enzymes is a central aspect of physiological

155 e degradation of basement membrane matrix by proteolytic enzymes is a hallmark of tumor invasion and

156 atrix (ECM) through the regulated release of proteolytic enzymes is a key process for development, mo

157 Degradation of Abeta by specific proteolytic enzymes is an important process that regulat

158 tion to this colloquium, the past history of proteolytic enzymes is briefly reviewed against the back

159 The activity of certain proteolytic enzymes is often an indicator of disease sta

160 Peptide mapping using proteolytic enzymes is one useful technique to character

161 mical evidence that cleavage by two distinct proteolytic enzymes is required for effective activation

162 hydrolysis of food proteins using commercial proteolytic enzymes is the most commonly employed proces

163 Genes in these regions include the proteolytic enzymes kallikrein (KLKB1) and Factor XII (F

164 ion is thought to be mediated by a family of proteolytic enzymes known as matrix metalloproteinases (

165 The proteins collected were identified using proteolytic enzymes, MALDI-TOF MS and MSFit database sea

166 Before the cleavage by its target, proteolytic enzyme MMP-2, the probe, an activatable cell

167 Whole human saliva contains a number of proteolytic enzymes, mostly derived from white blood cel

168 rm ciliary ectosomes, act as carriers of the proteolytic enzyme necessary for the liberation of daugh

169 roteinase inhibitors confine the activity of proteolytic enzymes of inflammatory cells, but fail to p

170 Protease sensitivity analysis using six proteolytic enzymes of varying specificity showed that R

171 Current methods require proteolytic enzymes or chemical agents and typically a s

172 Peptidases (proteolytic enzymes or proteases), their substrates and

173 The database has been expanded to include proteolytic enzymes other than peptidases.

174 When levels of acid and proteolytic enzymes overwhelm the mucosal defense mechan

175 r governed by the capacity to degrade ECM by proteolytic enzymes, particularly matrix metalloproteina

176 c stationary phase for immobilization of the proteolytic enzyme pepsin.

177 on an enzyme-assisted (EA) extraction using proteolytic enzymes (pepsin or pepsin-pancreatin).

178 ls and subjected to hydrolysis by SGID using proteolytic enzymes (pepsin, trypsin, chymotrypsin and p

179 min inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin.

180 activating human plasminogen to generate the proteolytic enzyme plasmin.

181 Parasite proteolytic enzymes play an essential but poorly underst

182 Proteolytic enzymes play fundamental roles in many biolo

183 sp molecules because treatment of hsp71 with proteolytic enzymes, polymyxin, or ATP abrogated this in

184 these findings suggest that the response of proteolytic enzyme preparations to static or free-fall p

185 These experiments showed that proteolytic enzymes present in the apoplasm and medium c

186 lows for the exposure of procytokines to the proteolytic enzymes produced by activated neutrophils, n

187 nd phloem revealed the existence of distinct proteolytic enzyme profiles within these tissues.

188 specific removal of fast inactivation by the proteolytic enzyme pronase eliminated charge immobilizat

189 The proteolytic enzyme Pronase reduced the uptake of transfe

190 sitivity of the B cell FCXM, we utilized the proteolytic enzyme pronase to remove Fc receptors from l

191 Proteolytic enzymes (proteases) participate in a vast ra

192 proteins may occur through the activation of proteolytic enzymes rather than exclusively through tran

193 ffects involve specific receptor activation, proteolytic enzymes, reactive oxygen species, or deliver

194 e extracellular matrix through production of proteolytic enzymes, release of proinflammatory factors

195 To identify the proteolytic enzyme responsible for shedding of meprin A,

196 n production and activity and determined the proteolytic enzymes responsible for corin cleavage.

197 ix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for myocardial extracell

198 Gamma-secretase is the second of two proteolytic enzymes responsible for the release of the a

199 should facilitate the identification of the proteolytic enzymes responsible for their formation.

200 e paradox of how functional loss of a single proteolytic enzyme results in an apparent increase in bo

201 ane protrusions and (b) functional for using proteolytic enzyme(s) for ECM degradation.

202 various pH values, (2) protein digestion by proteolytic enzyme(s), during which all the rapidly exch

203 le death is probably caused by the action of proteolytic enzymes secreted by neighboring fibroblasts.

204 Proteolytic enzymes secreted by the cold-adapted microor

205 -medium adhesion, and that increases in both proteolytic enzyme secretion rate and the coefficient of

206 between cell-cell and cell-medium adhesion, proteolytic enzyme secretion, cell birth and death proce

207 The protein chips with immobilized proteolytic enzymes showed the usefulness for fast in si

208 nd showed loss and gain of saliva-associated proteolytic enzymes, similar to NOD.B10-H2(b).C-Stat6(+/

209 Proteolytic enzyme studies indicate that the two histidy

210 in vitro by organomercurial compounds and by proteolytic enzymes such as trypsin, chymotrypsin, and s

211 eaved to some extent (ca. 50% after 24 h) by proteolytic enzymes, such as cathepsin B, cathepsin D, p

212 pared by cleaving the proteins with specific proteolytic enzymes, such as trypsin.

213 r research is aimed at the definition of the proteolytic enzyme systems in these oral streptococci wh

214 Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microb

215 Matrix metalloproteinase-9 (MMP-9) is a proteolytic enzyme that degrades the extracellular matri

216 amel matrix serine proteinase 1 (EMSP1) is a proteolytic enzyme that has been isolated from the devel

217 trate that the Kell blood group protein is a proteolytic enzyme that processes big ET-3, generating E

218 of matrix metalloproteinase 9 (MMP9), a key proteolytic enzyme that regulates wound remodeling.

219 as a chaperone at low temperatures and as a proteolytic enzyme that removes denatured or damaged sub

220 synergistically increasing micro-calpain, a proteolytic enzyme that targets E-cadherin.

221 est and activation of the caspase cascade of proteolytic enzymes that accompany apoptotic cell death.

222 roup of delayed response genes including two proteolytic enzymes that appear to execute the tail reso

223 Caspases are proteolytic enzymes that are closely involved in the ind

224 Caspases are proteolytic enzymes that are essential for apoptosis.

225 ovium produces proinflammatory cytokines and proteolytic enzymes that are important in the tissue deg

226 Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury and

227 and the system is subject to degradation by proteolytic enzymes that can break down its mechanical i

228 ix metalloproteinases (MMPs) are a family of proteolytic enzymes that can degrade all the components

229 e pulmonary disease and alters expression of proteolytic enzymes that contribute to disease pathology

230 metalloproteinases (MMPs) are extracellular proteolytic enzymes that contribute to pericellular remo

231 Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix pr

232 stresses may stimulate the cells to produce proteolytic enzymes that degrade the duct wall, making i

233 MMP-1, interstitial collagenase), one of the proteolytic enzymes that degrade type I collagen, in nor

234 elial and stromal cells and by production of proteolytic enzymes that facilitate the invasion of trop

235 ut some of these proteins are substrates for proteolytic enzymes that generate soluble cytokines with

236 determining the cleavage site specificity of proteolytic enzymes that involves pooled sequencing of p

237 Calpains are proteolytic enzymes that modulate cellular function thro

238 Matrix metalloproteinases (MMPs) are proteolytic enzymes that play an important role in these

239 xycycline can reach the choroid to attenuate proteolytic enzymes that remodel Bruch's membrane and pr

240 A low extracellular pH further activates proteolytic enzymes that remodel the extracellular matri

241 s and activational states of a family of ECM proteolytic enzymes, the matrix metalloproteinases (MMPs

242 atoid synoviocytes express a multiplicity of proteolytic enzymes, the primary effectors of cartilage,

243 a randomized, phase III, controlled trial of proteolytic enzyme therapy versus chemotherapy.

244 The proteolytic enzyme thrombin is produced during activatio

245 As a case study, we targeted the proteolytic enzyme thrombin, involved in blood coagulati

246 ni of two monomers (chains) were modified by proteolytic enzymes to different extents with no effect

247 Schistosomes employ proteolytic enzymes to digest host hemoglobin from inges

248 Blood-feeding parasites employ a battery of proteolytic enzymes to digest the contents of their bloo

249 The industrial preparation, modified within proteolytic enzyme, totally soluble (average 98%), was c

250 better quality of life than those who chose proteolytic enzyme treatment.

251 ubsequent treatment of plasma membranes by a proteolytic enzyme (trypsin) causes the loss of some of

252 A can be treated with mild concentration of proteolytic enzymes (trypsin or thermolysin).

253 iris and ciliary body was digested with the proteolytic enzyme V8 protease to solubilize the protein

254 rived by treatment of insoluble MAA with the proteolytic enzyme, V8 protease.

255 te targeting' by small-molecule effectors of proteolytic enzymes, which if generally applicable may s

256 alpain is a nearly ubiquitous Ca2+-activated proteolytic enzyme whose precise physiological function

257 f proteolytic activities or perhaps a single proteolytic enzyme with broad amino acid specificity.

258 alloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity agai

259 tion of NEP represents a unique example of a proteolytic enzyme with dual action, namely, degradation

260 In addition, the induction of a proteolytic enzyme within the Type II pneumocyte suggest