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1 ting that this form of PKM is not a PKC zeta proteolytic fragment.
2 e gamma-PAK as a full-length enzyme and as a proteolytic fragment.
3 ns have diverse effects on the levels of APP proteolytic fragments.
4 ecular functions of differentially localized proteolytic fragments.
5 phosphorylation, 18 duplicate genes, and 44 proteolytic fragments.
6 m the lipoprotein(a) (Lp(a)) particle, or as proteolytic fragments.
7 , as evidenced by a change in the pattern of proteolytic fragments.
8 to the alpha-subunit was mapped to two large proteolytic fragments.
9 arget proteins were selectively cleaved into proteolytic fragments.
10 sistant oligomers of pig gastric AE2 and its proteolytic fragments.
11 e with endoproteinase Glu-C produces several proteolytic fragments.
12 vative was identified by antibody mapping of proteolytic fragments.
13 tibody, we mapped the locations of the major proteolytic fragments.
14 st cancer cell lines were used to assess the proteolytic fragments.
15 analyses of ADAMTS-4, ADAMTS-5, and aggrecan proteolytic fragments.
16 nits of a protein complex can yield isomeric proteolytic fragments.
17 -length proteins and their in situ-generated proteolytic fragments.
18 t but resulted in the secretion of two apo B proteolytic fragments (80 and 120 kD), which were found
19 17 x 10(6) M(-1)) were close to those of Fab proteolytic fragments (9.78 x 10(6) M(-1)) derived from
20 SR) of SP-B measured using the most abundant proteolytic fragment, a 10 amino acid peptide from the c
21 a precursor protein, and accumulation of its proteolytic fragment Abeta; (b) accumulations of phospho
23 ues has nuclease activity, whereas no stable proteolytic fragments accumulate from the N-terminal por
24 ed endocytosis and the transport of a 37-kDa proteolytic fragment across a membrane into the cytoplas
26 h PS1 and PS2 are each processed into stable proteolytic fragments after their biosynthesis in transf
28 pha by various methods (mass spectrometry of proteolytic fragments, amino acid analysis, molecular we
29 he amyloid-beta precursor protein and of its proteolytic fragment, amyloid-beta, associated with the
31 e molecule in solution but is exposed on the proteolytic fragments and probably when fibronectin is i
32 ructure and folding of the repressor and its proteolytic fragments and show excellent agreement for t
35 have been generated against sequences in the proteolytic fragments and used to demonstrate the time c
36 n in full-length human APPswe as well as its proteolytic fragments, and ameliorates cognitive deficit
38 nce common to all active synthetic peptides, proteolytic fragments, and recombinant constructs of Ebp
39 Using naturally occurring thymosin beta4, proteolytic fragments, and synthetic peptides, we find t
40 recursor (67 kDa) from eight non-overlapping proteolytic fragments, and the identity was confirmed by
41 accounting for the earlier observation that proteolytic fragments ( approximately 35 kDa) of lucifer
42 RNA synthetase (TrpRS) and a similar natural proteolytic fragment are potent angiostatic factors that
44 as it is from the Abeta monomer, while other proteolytic fragments are generated much more slowly.
47 ength beta(2)m induces pathophysiology or if proteolytic fragments are sufficient for inducing this e
48 tic activity, calpain also produces a stable proteolytic fragment at 50kDa using recombinant MetAP2.
49 Following the substrate cleavage, only the proteolytic fragments bearing biotin moieties are captur
50 abeling was contained within a 20-kilodalton proteolytic fragment beginning at Ser(173) that contains
51 incorporation was contained within a 20-kDa proteolytic fragment beginning at Ser-173, with alphaTyr
52 (APP) and intracellular accumulation of its proteolytic fragment beta-amyloid play a central role in
55 ical APP processing pathway, which generates proteolytic fragments capable of inhibiting neuronal act
56 ll-length Dll1, but not its N- or C-terminal proteolytic fragment, co-immunoprecipitates with ADAM12.
57 (APP) and intracellular accumulation of its proteolytic fragments collectively known as beta-amyloid
58 cell co-transfectants, we demonstrate that a proteolytic fragment consisting of the extravesicular do
60 nly in the alpha subunit with 70% being in a proteolytic fragment containing the M4 transmembrane seg
64 intact polypeptides and mass spectrometry of proteolytic fragments demonstrated that the 142-kD form
69 d reactivity for a calpain-specific spectrin proteolytic fragment during the period of recovery from
71 In addition, one of the major N-terminal Htt proteolytic fragments found in human HD tissue appears t
73 our original suggestion that zeugmatin is a proteolytic fragment from the N-terminal region of titin
76 dependent excitatory synaptogenesis, via two proteolytic fragments generated by calpain cleavage.
79 nt data suggest that ARS molecules and their proteolytic fragments generated during the cell death pr
80 sely related homolog by sequence analysis of proteolytic fragments generated from the purified enzyme
81 d CaM induced alterations in the kinetics of proteolytic fragment generation during limited trypsinol
83 in digests by MALDI-MS because these anionic proteolytic fragments have low ionization efficiencies.
84 erative binding (ka) of both gp32 and of its proteolytic fragment *I (which lacks 48 residues from th
85 on is supported by the observations that SUS proteolytic fragments: (i) were detected and possessed r
86 spectrometry (MALDI-MS) characterization of proteolytic fragments identified disulfide bonds between
88 ated Edman degradation of native CP2 and its proteolytic fragments in conjunction with mass spectrome
90 ighted the generation of specific C-terminal proteolytic fragments, in particular the accumulation of
92 Proteolysis of PTPmu generates a series of proteolytic fragments, including a soluble catalytic int
94 In both reactions, the extreme N-terminal proteolytic fragment is released from fibrils as rapidly
95 -terminal sequence analysis of nAChR-subunit proteolytic fragments isolated by SDS-PAGE and/or revers
96 s to the 3'-5' exonuclease site of the large proteolytic fragment (Klenow fragment) of DNA polymerase
99 iption factor/antitoxin MrpC and its related proteolytic fragment MrpC2 are increased, inhibiting the
101 through improved insulin sensitivity, and a proteolytic fragment of adiponectin stimulates beta oxid
104 ement program, expressed a novel M(r) 75,000 proteolytic fragment of beta-catenin (beta-cat(75)).
105 ithdrawal support the conclusion that CCt, a proteolytic fragment of Ca(V)1.2, autoregulates Ca(V)1.2
111 escribed wherein SAMDI is used to identify a proteolytic fragment of cystatin C in cerebral spinal fl
113 anscription is induced by D dimer, a plasmin proteolytic fragment of fibrin, supporting its role in n
114 Furthermore, application of fibronectin or a proteolytic fragment of fibronectin containing the centr
117 Link protein N-terminal peptide (LPP) is a proteolytic fragment of link protein, an important cross
118 oth muscle heavy meromyosin, a double-headed proteolytic fragment of myosin lacking the COOH-terminal
120 Protein sequencing of an internal 61-kDa proteolytic fragment of NTPPHase (61-kDa NTPPHase) deter
127 ough the therapeutic value of angiostatin, a proteolytic fragment of plasminogen, has been recognized
132 ease-sensitive site results in an N-terminal proteolytic fragment of Pol2, called Pol2core, that cons
134 inal amino acid sequencing of a 16-kDa Lys-C proteolytic fragment of the 23-kDa storage granule prote
135 e plaques is amyloid-beta peptide (Abeta), a proteolytic fragment of the amyloid precursor protein (A
136 y at single-residue resolution a 156-residue proteolytic fragment of the androgen receptor that conta
139 th this cDNA insert representing an internal proteolytic fragment of the full length 127-kDa NTPPHase
140 ariant chain-derived peptide (CLIP), a short proteolytic fragment of the invariant chain, and exhibit
141 motif(s) is located within the NH2-terminal proteolytic fragment of the protein consisting of residu
144 f aggregated amyloid beta peptide (Abeta), a proteolytic fragment of the transmembrane amyloid precur
146 nits, specific labeling was contained within proteolytic fragments of 14 and 21 kDa, respectively, be
147 3A)R subunit was initially mapped to subunit proteolytic fragments of 8 kDa, containing the M4 transm
149 ess, which may be initiated by IDE-generated proteolytic fragments of Abeta, was prevented by three d
151 of proteins within virus particles detected proteolytic fragments of alpha-smooth muscle actin and m
152 identified 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins rele
153 ve different N-terminal lipid modifications, proteolytic fragments of alphao isoforms were immunoprec
154 associated with extracellular deposition of proteolytic fragments of amyloid precursor protein (APP)
155 e, because 1 month of activity decreased the proteolytic fragments of APP [for alpha-C-terminal fragm
156 mapping and N-terminal sequence analysis of proteolytic fragments of azidoATP-photolabeled GLUT1.
157 d by automated Edman degradation analysis of proteolytic fragments of both the heavy and light chains
163 lpha(5) integrin also reversed the effect of proteolytic fragments of denatured collagen on contracti
164 expression is modulated in part by specific proteolytic fragments of fibronectin (FN), which are ass
165 etitive binding assays using recombinant and proteolytic fragments of FN revealed that the cell-bindi
167 bind to non-GPCR nuclear signaling proteins, proteolytic fragments of GPCRs capable of ligand-indepen
168 our group have implicated calpain-dependent proteolytic fragments of menin, the product of the MEN1
169 id disease associated with the deposition of proteolytic fragments of mutant (D187N/Y) plasma gelsoli
173 from porcine plasma, and sequencing of four proteolytic fragments of pICA revealed that each of the
176 ied fractions of plasma fibrinogen, purified proteolytic fragments of plasma fibrinogen, recombinant
178 RG was localized to the H/P domain by use of proteolytic fragments of rbHPRG and was further confirme
179 c inflammatory conditions that develops when proteolytic fragments of serum amyloid A protein (SAA) a
183 binding class II molecules, we have studied proteolytic fragments of the I chain generated both by n
184 ified by amino-terminal sequence analysis of proteolytic fragments of the Na,K-ATPase alpha-subunit a
190 pondin-1 (TSP1) based on activities of large proteolytic fragments of TSP1 or peptides containing TSP
191 xpression of OLE1 is activated by N-terminal proteolytic fragments of two homologous endoplasmic reti
193 cked the inhibitory effect of chromogranin A proteolytic fragments on nicotinic-stimulated catecholam
194 in D3, preceding A1, and corresponded to the proteolytic fragment originally identified as the GP Iba
197 inal, the noncovalent interactions among the proteolytic fragments produced by papain and chymotrypsi
198 d the N-terminal amino acid sequences of the proteolytic fragments produced by the processing events.
200 tions and under agitation the residue 49-127 proteolytic fragment rapidly and completely self-aggrega
206 CH, PSH and AMA in relation to levels of APP proteolytic fragments reported from AD-associated mutati
207 (5) CV2 binds even more strongly to Chordin proteolytic fragments resulting from Tolloid digestion o
208 ion kinetics in the presence of gp32 and its proteolytic fragments reveal three types of kinetic beha
209 ification and sequencing of the radiolabeled proteolytic fragments revealed that each of Ssa1p's thre
210 nt fusion protein was similar to that of the proteolytic fragment seen in NMU cells transformed with
211 wever, MALDI signals from the phosphorylated proteolytic fragments sometimes increase dramatically wh
212 (C364S) prevented the generation of smaller proteolytic fragments, suggesting that the processing mi
213 sin generates reproducible patterns of large proteolytic fragments that are consistent with the forma
214 calmodulin is initially degraded into large proteolytic fragments that are released from the proteas
215 he high prevalence of endogenous CgA and CgB proteolytic fragments that function in chromaffin secret
216 ke other LCAT enzymes it is cleaved into two proteolytic fragments that share the residues of the cat
217 ide assays and sequencing of radiolabeled L1 proteolytic fragments, the phosphorylation site was dete
218 he delinking of the frozen topoisomerase (or proteolytic fragments thereof) from the DNA substrate, w
219 the functions of human myocilin and its two proteolytic fragments, these proteins were expressed in
220 proteolysis and the ability of the resulting proteolytic fragments to form multiply charged negative
221 , we noted evidence for cross-linking of AE2 proteolytic fragments to higher-order oligomeric forms.
223 illary channel followed by separation of the proteolytic fragments using capillary electrophoresis (C
227 y folded as its pattern of stable C-terminal proteolytic fragments was identical to that of native br
228 s in the predicted N-terminal and C-terminal proteolytic fragments, we demonstrate that the BEHAB/bre
229 pproximately 76 and approximately 56 kDa IDE proteolytic fragments were active toward the physiologic
230 reduction, the obtained approximately 25 kDa proteolytic fragments were analyzed by reversed phase li
231 with Abeta40 and Abeta42, and the resulting proteolytic fragments were assessed via immunoprecipitat
234 ormation and degradation of the six produced proteolytic fragments were significantly different, howe
235 and subjected to protease digestion, and the proteolytic fragments were subjected to mass spectroscop
236 pes, and the concomitant release of a 70-kDa proteolytic fragment, which correlated with a reduced ab
237 tase 1B (PTP1B) corresponding to the calpain proteolytic fragment, which indicates that calpain modul
238 oth endogenous and added SecA yield the same proteolytic fragments, which are distinct from those obt
239 onic functionalities permits detection of 22 proteolytic fragments, while analysis using a stainless
240 lastic A-band part of the protein, and for a proteolytic fragment with 100-nm contour length from the
241 DE approximately 76 and approximately 56 kDa proteolytic fragments with a synthetic fluorogenic subst
242 -2, -3, -7, -9, and -12 resulted in similar proteolytic fragments with MMP-7 and -12 being the most
243 ied by gel analysis of fluorescently labeled proteolytic fragments with the aid of Western blotting w
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