ライフサイエンスコーパス: proteolytic processing

1 nriched, truncated NRG1 protein resistant to proteolytic processing.

2 GTPase OPA1, whose activity is regulated by proteolytic processing.

3 l flexibility may thus change the pattern of proteolytic processing.

4 ndolysosomal compartments and its subsequent proteolytic processing.

5 onstrating E-cad overexpression and specific proteolytic processing.

6 oteins and activated by the inflammasome via proteolytic processing.

7 sing RNAi that TC10alpha is required for TUG proteolytic processing.

8 play altered gamma-secretase-dependent Notch proteolytic processing.

9 upling entry into the endocytic pathway with proteolytic processing.

10 post-translation modifications, isoforms and proteolytic processing.

11 ocally in tissues and is itself regulated by proteolytic processing.

12 ms, but there is little information on TWEAK proteolytic processing.

13 452) is essential for the initiation of DSPP proteolytic processing.

14 terminus and 65 kDa carboxy terminus, after proteolytic processing.

15 e availability of APP for secretase-mediated proteolytic processing.

16 endoplasmic reticulum (ER) to the Golgi for proteolytic processing.

17 es many important signaling proteins through proteolytic processing.

18 tase (RT) instability as well as inefficient proteolytic processing.

19 alpha- and betaB-subunit mRNA, protein, and proteolytic processing.

20 protein while retaining similar kinetics of proteolytic processing.

21 that these mutant proteins were impaired in proteolytic processing.

22 via inhibition of CA-SP1 cleavage during Gag proteolytic processing.

23 rhomboid family protease required for SREBP proteolytic processing.

24 1 and a type 2 orientation are generated by proteolytic processing.

25 the secreted precursor protein, DfsB, after proteolytic processing.

26 he channel from entering a state that allows proteolytic processing.

27 without affecting its Golgi localization and proteolytic processing.

28 are fully concealed and independent of their proteolytic processing.

29 ting in AMIGO2 silencing and changes in PTK7 proteolytic processing.

30 is activated during ageing and mediates APP proteolytic processing.

31 n destruction complex by gingipain-dependent proteolytic processing.

32 SIRT2 deletion increased TUG acetylation and proteolytic processing.

33 ation status of beta-catenin but resulted in proteolytic processing.

34 s to facilitate LC-MS/MS characterization of proteolytic processing, a major form of posttranslationa

35 ubunits are modified post-translationally by proteolytic processing, acetylation, and/or ubiquitylati

36 isive role in controlling the outcome of APP proteolytic processing and Abeta generation.

37 The presented DISC1 mechanism of APP proteolytic processing and Abeta peptide generation, whi

38 n type III NRG1 that disrupt intramembranous proteolytic processing and abolish intracellular domain

39 enzyme that is internalized and subjected to proteolytic processing and activation in lysosomes.

40 CIRL in the GPS domain inhibit intracellular proteolytic processing and also result in the absence of

41 s of lacritin is multifunctional by dose and proteolytic processing and appears to play a key role in

42 P combination enhances mature glycosylation, proteolytic processing and cell-surface expression of al

43 -GX sPLA2 is a substrate for furin and PCSK6 proteolytic processing and define a novel mechanism for

44 iquitination is associated with irreversible proteolytic processing and inactivation of Bag6.

45 This is followed by proteolytic processing and mobilization of the transcrip

46 e absence of Hh, Cos2 and Kif7 contribute to proteolytic processing and silencing of the Hh-regulated

47 However, the location(s) of proteolytic processing and subsequent secretion of APP f

48 virulence activity of AvrRPS4 requires both proteolytic processing and the KRVY motif at the N-termi

49 wnstream target genes through the control of proteolytic processing and the transcriptional activatio

50 the inner membrane before the FtsH-dependent proteolytic processing and translocation of the toxic tR

51 mal degradation pathway and autophagy on the proteolytic processing and turnover of C99.

52 the expanded PolyQ region can be produced by proteolytic processing and/or aberrant splicing.

53 ar those that perturbed particle production, proteolytic processing, and particle-associated IN level

54 udy the biosynthesis, cell-surface delivery, proteolytic processing, and release of soluble EGFR liga

55 atures of Env involved in protein stability, proteolytic processing, and virus assembly and entry, th

56 ment LG3 is generated at increased levels by proteolytic processing as long as 3 days after ischemia.

57 oteinases as being primarily responsible for proteolytic processing (as opposed to degradation) durin

58 the viral fusion (F) protein, which requires proteolytic processing at a basic cleavage site in order

59 ose bioactivity is closely regulated through proteolytic processing at its C terminus.

60 Proteolytic processing at N- and C-terminal sites of the

61 We demonstrate that native BB0323 undergoes proteolytic processing at the C-terminus, at a site afte

62 Chymotrypsin zymogen is activated by proteolytic processing at the N terminus, resulting in s

63 th both nucleocapsid and matrix domains, and proteolytic processing at the spacer peptide 1|nucleocap

64 oid precursor protein (APP) with consecutive proteolytic processing: beta-secretase, followed by gamm

65 one or together with YXXPhi, did not prevent proteolytic processing but increased cell surface expres

66 ts suggest a direct relationship between APP proteolytic processing, but not amyloid-beta, in GSK-3be

67 in the lymphovascular embolus, E-cad and its proteolytic processing by calpain and other proteases ha

68 demonstrate that TREM2 undergoes sequential proteolytic processing by ectodomain shedding and intram

69 t a 25-kDa fragment, probably resulting from proteolytic processing by eta-secretase.

70 o assessed the affect of lattice assembly on proteolytic processing by exogenous PR.

71 nimum of two events are required for fusion, proteolytic processing by furin-like proteases and expos

72 are synthesized as proproteins that undergo proteolytic processing by furin/subtilisin proprotein co

73 myloid precursor protein (APP) is subject to proteolytic processing by gamma-secretase within neurona

74 n shedding by alpha-secretase and subsequent proteolytic processing by gamma-secretase.

75 Structural changes in DeltaGag upon proteolytic processing by HIV-1 protease, monitored by N

76 Proteolytic processing by matrix metalloproteinase-20 (M

77 fensins protects the mature peptides against proteolytic processing by MMP-7.

78 y deleted, provided that the requirement for proteolytic processing by PLP1 was offset by an alternat

79 le-pass transmembrane protein that undergoes proteolytic processing by secretases to generate the pat

80 In addition to the proteolytic processing by secretases, APP is also metabo

81 epatitis C virus (HCV) core protein requires proteolytic processing by two host proteases: signal pep

82 ene expression levels and post-translational proteolytic processing can be controlled.

83 inding consistent with P. gingivalis-induced proteolytic processing causing the increase in TCF/LEF p

84 Since changes in lectican abundance and proteolytic processing did not accompany the synaptic pr

85 for insulin enhancement of SREBP-1c mRNA and proteolytic processing diverge after mTORC1.

86 we showed that regulation of FANCC involved proteolytic processing during apoptosis.

87 inent yet previously uncharacterized role of proteolytic processing during platelet storage.

88 an unanticipated role of IN for polyprotein proteolytic processing during virion morphogenesis.

89 Post-translational modification, proteolytic processing, endocytosis and membrane traffic

90 erated on the expressed IgG1 Fc by utilizing proteolytic processing enzymes in the yeast secretory pa

91 We demonstrate that this novel proteolytic processing event depends on a two-step casca

92 PKA is known to be required for the proteolytic processing event that generates the represso

93 thways and physiologic processes to specific proteolytic processing events is a major challenge in si

94 The proteolytic processing events of the alpha and gamma sub

95 ination cycling specifically regulates later proteolytic processing events required for destruction o

96 proteases in Giardia have been implicated in proteolytic processing events that enable the continuanc

97 DD8 is translated as a precursor protein and proteolytic processing exposes a C-terminal glycine requ

98 otch with membrane-anchored ligands triggers proteolytic processing, first by Adam10 and then preseni

99 the context of a polyprotein that undergoes proteolytic processing for NS5 maturation.

100 ins than in controls, while genes related to proteolytic processing (for example, LGMN, CTSZ) were hy

101 Site-specific mutagenesis to prevent proteolytic processing generated a full-length enzyme th

102 Although proteolytic processing goes to completion, the rate of c

103 peptide derived from VGF (non-acronymic) by proteolytic processing, has been shown to modulate energ

104 49) and His(151) to asparagine decreased APP proteolytic processing, impaired APP endoplasmic reticul

105 -mediated shedding and highlight the role of proteolytic processing in prion disease.

106 Toll-like receptor (TLR) 9 requires proteolytic processing in the endolysosome to initiate s

107 for p38 MAPK phosphorylation fail to undergo proteolytic processing in the Golgi apparatus and drive

108 redistribution toward the basolateral side, proteolytic processing in the membranes, and excretion i

109 a requirement for Taspase 1-dependent TFIIA proteolytic processing in the mouse testis to enable TRF

110 xpressed and is subject to posttranslational proteolytic processing in the retina, brain, and kidney.

111 t evidence that chemerin undergoes extensive proteolytic processing in vivo, underlining the importan

112 at most mutations do not disrupt expression, proteolytic processing, incorporation into virus, or rec

113 at several levels, including transcription, proteolytic processing, inhibition of enzymatic function

114 Proteolytic processing inside producing cells is a novel

115 cate that annexin A1 externalization and its proteolytic processing into a chemotactic peptide repres

116 cytokines lack a signal peptide and require proteolytic processing into an active molecule.

117 disease, has a complex biology that includes proteolytic processing into potentially toxic fragments,

118 orm of DMP1 is an inactive precursor and its proteolytic processing is an activation step essential t

119 Together, our data demonstrate that proteolytic processing is an important event that allows

120 Proteolytic processing is dispensable for hydrolytic sul

121 Taken together, our data indicate that TLR3 proteolytic processing is essential for its function, an

122 e we introduce a molecular probe, which upon proteolytic processing is retained at the site of enzyme

123 eavage of the transit peptide and additional proteolytic processing, mature HMR, which begins from Ly

124 sibility that targeting aberrant splicing or proteolytic processing may present attractive therapeuti

125 Therefore, the two-step proteolytic processing may represent a regulatory mechan

126 Tal(2009) and Tal(901-1) can undergo proteolytic processing mid-protein at the glycine-rich s

127 ddition to changes in PrPC glycosylation and proteolytic processing, net reductions in PrPC occur in

128 sponsive transcription factor PacC, and PacC proteolytic processing occurred normally during calcium

129 Proteolytic processing of 38-kDa CTGF occurs during corn

130 n C (SP-C) by alveolar type 2 cells requires proteolytic processing of a 21-kDa propeptide (proSP-C21

131 We show that transcript abundance as well as proteolytic processing of a borrelial protein required f

132 Pg/NIaPro, NIb, and CP, all derived from the proteolytic processing of a large polyprotein, and an ad

133 Proteolytic processing of alpha2delta then permits volta

134 beta-Amyloid peptides (Abeta), derived from proteolytic processing of amyloid precursor protein (APP

135 myloid beta (Abeta) peptide derived from the proteolytic processing of amyloid precursor protein (APP

136 Proteolytic processing of amyloid precursor protein (APP

137 Proteolytic processing of amyloid precursor protein (APP

138 We report the novel regulation of proteolytic processing of amyloid precursor protein (APP

139 embrane aspartyl protease that catalyzes the proteolytic processing of APP and other plasma membrane

140 This sequestration significantly delayed the proteolytic processing of APP by secretases and the prot

141 ral and dynamic features are critical in the proteolytic processing of APP by the gamma-secretase enz

142 Here, we investigated expression and proteolytic processing of APP during differentiation of

143 proteins is required for the P2X7R-dependent proteolytic processing of APP leading to sAPPalpha relea

144 Proteolytic processing of ataxin-7 by caspase-7 generate

145 IFN-stimulated proteolytic processing of ATF6 and ERK1/2-mediated phosp

146 IFN-gamma-induced proteolytic processing of ATF6 and phosphorylation of C/

147 nduced expression of DAPK1 IFN-gamma-induced proteolytic processing of ATF6 and phosphorylation of C/

148 Importantly, active proteolytic processing of AtMCP2d proteins dependent on

149 In addition, proteolytic processing of cadherin extracellular and cyt

150 causing altered febrile responses, increased proteolytic processing of caspase-1, and more rapid infl

151 In cells, F1L inhibits apoptosis and proteolytic processing of caspases induced by overexpres

152 I3C directly inhibits the elastase-mediated proteolytic processing of CD40, which alters downstream

153 SPPL2A deficiency blocked the proteolytic processing of CD74 MHC II invariant chain in

154 n, and DNA replication and reveal widespread proteolytic processing of cellular proteins to generate

155 s a polytopic membrane protein that inhibits proteolytic processing of CREB3L1 (cAMP response element

156 Proteolytic processing of CTGF in HCF cultures, normal a

157 This study addresses the role of proteolytic processing of CTGF in human corneal fibrobla

158 In addition to liver, the enhanced proteolytic processing of CtsB was also observed in brai

159 Proteolytic processing of defensins is a critical mode o

160 t D213A substitution effectively blocked the proteolytic processing of DMP1 in vivo.

161 13A-Tg mice) to test the hypothesis that the proteolytic processing of DMP1 is an activation step ess

162 These findings indicate that the proteolytic processing of DMP1 is essential to the forma

163 t D452A substitution effectively blocked the proteolytic processing of DSPP in vivo.

164 These results indicate that the proteolytic processing of DSPP is an activation step ess

165 We believe that the proteolytic processing of DSPP is an essential activatio

166 ere we report that phosphorylation-regulated proteolytic processing of EIN2 triggers its endoplasmic

167 to lymphatic vessels stimulated release and proteolytic processing of endothelium-derived Reelin.

168 Proteolytic processing of epithelial sodium channel (ENa

169 This is an intriguing cue, since proteolytic processing of extracellular matrix macromole

170 ly on ameloblast-ameloblast interactions and proteolytic processing of extracellular matrix proteins

171 dent ubiquitination in controlling the later proteolytic processing of G protein-coupled receptors, w

172 We hypothesized that proteolytic processing of gammaENaC occurs in the human

173 a function, we find that cilia formation and proteolytic processing of Gli3 are disrupted in C2cd3 mu

174 of Hh signaling, is down-regulated, and the proteolytic processing of Gli3 is compromised.

175 we had provided evidence of tissue-specific proteolytic processing of histone H3 in White Leghorn ch

176 ells exhibited markers of lysosomal-mediated proteolytic processing of histones and were progressivel

177 dition, A3G and Mov10 overexpression reduced proteolytic processing of HIV-1 Gag.

178 edly, T124N/T174I IN substitutions inhibited proteolytic processing of HIV-1 polyproteins Gag and Gag

179 Our understanding of proteolytic processing of Htt has thus far focused on th

180 Proteolytic processing of human host cell factor 1 (HCF-

181 regulated in large part by the extracellular proteolytic processing of hyaluronan-bound proteoglycan.

182 ediated knockout of caspase b, which acts by proteolytic processing of il1beta, results in increased

183 activate the inflammasome complex and drive proteolytic processing of inflammatory cytokines; howeve

184 ermed "inflammasomes," which are involved in proteolytic processing of interleukin-1beta (IL-1beta) a

185 ote T cell activation was due to inefficient proteolytic processing of internalized ICs.

186 ng through the other branches of the UPR, or proteolytic processing of its close homolog ATF6beta or

187 cum AMB-1, was recently shown to promote the proteolytic processing of itself and two other biominera

188 ode of growth is associated with an abnormal proteolytic processing of L1 and N-cadherin, two ADAM10

189 Heat shock-induced proteolytic processing of Lsb1 is crucial for prion main

190 impaired lysosomal acidification, decreased proteolytic processing of lysosomal enzymes, reduced deg

191 trostudies showing that FAP mediates ordered proteolytic processing of matrix metalloproteinase (MMP)

192 Post-translational proteolytic processing of mature chemokines is a key, ye

193 We show here that proteolytic processing of Msb2p was induced by underglyc

194 SP1-specific antibodies shown to inhibit the proteolytic processing of MSP1 that occurs at invasion.

195 roteolysis of APP, BACE1 participates in the proteolytic processing of neuregulin 1 (NRG1) and influe

196 abnormalities, and pcd mice display altered proteolytic processing of Nna1 interacting proteins.

197 ubsequent study suggested that site-specific proteolytic processing of Nrf1 by the proteasome yields

198 Here we investigated proteolytic processing of NRG1 type III and demonstrate

199 ression and the subcellular distribution and proteolytic processing of NRG1-IVNV isoforms were also d

200 aracterized the synaptic consequences of the proteolytic processing of Nrxns in cultured hippocampal

201 min-related protein 1) at Ser637 and altered proteolytic processing of OPA1 (optic atrophy 1).

202 Proteolytic processing of PKCalpha by calcium-activated

203 Recently, we showed that calpain-mediated proteolytic processing of PKCalpha in ischemic myocardiu

204 ic function, we address the relevance of the proteolytic processing of presynaptic neurexins (Nrxns)

205 e that mature L-SMase arises from C-terminal proteolytic processing of pro-aSMase and suggest that im

206 or activation of Met signaling that bypasses proteolytic processing of pro-HGF.

207 nt molecular protein complex which initiates proteolytic processing of pro-IL-1beta and pro-IL-18 int

208 scription whereas inflammasomes regulate the proteolytic processing of pro-IL-1beta.

209 d profound effects on MHC-I presentation and proteolytic processing of proinsulin.

210 Nalpha acetylation, protein maturation, and proteolytic processing of proteins in human platelets.

211 m open reading frame repression requires the proteolytic processing of PTEF by PfCalpain.

212 drive the amyloid cascade in AD and that the proteolytic processing of RanBP9 may be an attractive th

213 valent modification in controlling the later proteolytic processing of receptors.

214 h is essential for viral replication through proteolytic processing of RNA replicase machinery.

215 Adenovirus maturation involves proteolytic processing of seven precursor proteins.

216 Adenovirus assembly concludes with proteolytic processing of several capsid and core protei

217 amily of endosomal proteases is required for proteolytic processing of several viruses during entry i

218 these studies, it has become recognized that proteolytic processing of signaling molecules by certain

219 n collagen fibril assembly is the C-terminal proteolytic processing of soluble procollagen precursors

220 CMV infection was also found to increase the proteolytic processing of SREBP-2, a transcription facto

221 notion that proper vacuolar trafficking and proteolytic processing of storage proteins require endom

222 Proteolytic processing of synaptic adhesion components c

223 Interestingly, the observed proteolytic processing of Tal(2009) and Tal(901-1) facil

224 Because cathepsins are known to influence proteolytic processing of Tg in vivo, we examined in thi

225 tural dimer, 3,3'-diindolylmethane, disrupts proteolytic processing of the 50-kDa cyclin E into the l

226 effects of elastase on receptor activation, proteolytic processing of the adhesion protein ICAM-1, N

227 Abeta is generated by the proteolytic processing of the amyloid precursor protein

228 in Alzheimer's disease (AD), is generated by proteolytic processing of the amyloid precursor protein

229 There is compelling evidence that the proteolytic processing of the amyloid precursor protein

230 Alzheimer's disease (AD) is associated with proteolytic processing of the amyloid precursor protein

231 Proteolytic processing of the amyloid precursor protein

232 Proteolytic processing of the amyloid-beta precursor pro

233 re in that its maturation requires extensive proteolytic processing of the astrovirus capsid protein

234 Maturation of HAstV requires proteolytic processing of the astrovirus CP both inside

235 gene and represent products of intracellular proteolytic processing of the CIRL precursor.

236 ease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is c

237 pitope presentation at a step other than the proteolytic processing of the epitope.

238 Proteolytic processing of the flavivirus polyprotein is

239 hybridization and immunostaining and confirm proteolytic processing of the FRFamide precursor by mass

240 that in skeletal muscle, insulin stimulates proteolytic processing of the GLUT4 retention protein, T

241 Apparently, proteolytic processing of the HIV-1 Env precursor decrea

242 Remarkably, proteolytic processing of the HIV-1 Env precursor result

243 Proteolytic processing of the laminin-gamma2 chain is a

244 When L2 expression was repressed, proteolytic processing of the major core proteins and th

245 We have demonstrated proteolytic processing of the matrix proteoglycan, versi

246 , insulin rapidly and selectively stimulates proteolytic processing of the nascent SREBP-1c by enhanc

247 Proteolytic processing of the nuclear factor (NF)-kappaB

248 Proteolytic processing of the pigment cell-specific Mela

249 but there was no change in the abundance or proteolytic processing of the prominent lecticans brevic

250 Proteolytic processing of the protein leads to a number

251 how cleavage might activate membrane fusion, proteolytic processing of the SARS-CoV S protein remains

252 tern blot analysis revealed an age-dependent proteolytic processing of the TGFBIp N terminus resultin

253 omplex array of glycosylation substrates and proteolytic processing of the transcription factor host

254 Proteolytic processing of the viral nonstructural polypr

255 inhibitor and exhibit a significant delay in proteolytic processing of the viral replicase polyprotei

256 ctivate KLKs because of gingipain K-mediated proteolytic processing of the zymogenic proform of KLK13

257 ation of collagen metabolism by uPA-mediated proteolytic processing of transforming growth factor (TG

258 Immunoblots demonstrated that proteolytic processing of TRAP5b and the cytoskeletal pr

259 To determine whether peptides derived from proteolytic processing of VGF participate in nociceptive

260 ivity of endosomal proteases or delaying the proteolytic processing of virions.

261 Proteolytic processing of von Willebrand factor (VWF) by

262 uggest that FVIII plays a role in regulating proteolytic processing of VWF by ADAMTS13 under shear st

263 to the trans-Golgi network (TGN) to prevent proteolytic processing or by directing newly produced Ab

264 variations are not caused by differences in proteolytic processing or degrees of phosphorylation or

265 processed by TDP2 unless they first undergo proteolytic processing or denaturation.

266 signaling proteins IKKbeta and IKKgamma, the proteolytic processing p105 and p100 and NF-kappaB DNA b

267 cell culture model to investigate huntingtin proteolytic processing; previous studies of these cells

268 Contrary, in PNS glia, but not in neurons, proteolytic processing produced a two-chain SorCS2 isofo

269 at axonal entry and secretion of APP and its proteolytic processing products traverse different pathw

270 ined with the appropriate enzymes to analyze proteolytic processing rates in the presence or absence

271 Here we demonstrate that proteolytic processing regulates the biological activity

272 Subsequent proteolytic processing releases the toxic compound insid

273 that Sonic hedgehog (Shh) is solubilized by proteolytic processing (shedding) of lipidated peptide t

274 eavage fragments produced by pathogen-driven proteolytic processing should be further characterized t

275 without altering cell surface expression or proteolytic processing significantly.

276 Multiple proteolytic processing sites in Glass bottom boat (Gbb),

277 We demonstrate that HERV-K ENV undergoes a proteolytic processing step and triggers membrane fusion

278 w that PmpD undergoes an infection-dependent proteolytic processing step late in the growth cycle tha

279 w here that Fat is subject to a constitutive proteolytic processing, such that most or all cell surfa

280 hundreds of peptides in different levels of proteolytic processing that may provide a range of biolo

281 In the cell, monomeric gp12 undergoes proteolytic processing that releases the C-terminal doma

282 r knowledge, the first example of tail fiber proteolytic processing that results in a heterogeneous p

283 e site of protein VI that profoundly impacts proteolytic processing, the generation of infectious par

284 this study, we demonstrate that, after hTLR7 proteolytic processing, the liberated amino (N)-terminal

285 A proteolytic processing then transforms the proenzyme int

286 cked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability t

287 Da proenzyme and then undergoes biosynthetic proteolytic processing to active approximately 30 kDa LO

288 Whether TLR3 requires similar proteolytic processing to become competent for signaling

289 Nrf1 was reported to require proteolytic processing to enter the nucleus [3].

290 LOX protein and then undergoes extracellular proteolytic processing to form approximately 30 kDa LOX

291 s constitutively active and does not require proteolytic processing to function.

292 ssibility to the aqueous environment undergo proteolytic processing to generate active neuropeptides

293 ized the necessity of appropriate C-terminal proteolytic processing to generate the likely physiologi

294 rmore, both increased CAMP secretion and its proteolytic processing to LL-37 are required for antimic

295 ly transcription factors and prevents Ci/Gli proteolytic processing to repressor forms.

296 This proteolytic processing, unusually extensive for an envel

297 hereas certain NLRs trigger their subsequent proteolytic processing via caspase 1.

298 A1 during secondary necrosis coincided with proteolytic processing within its unique N-terminal doma

299 Activation of TLR9 for signaling requires proteolytic processing within the ectodomain by endosome

300 sm of aSMase maturation involving C-terminal proteolytic processing within, or in close proximity to,