ライフサイエンスコーパス: proteolyze

1 actor variants that Rce1p may not be able to proteolyze.

2 ytic than chymosin and that kappa-casein was proteolyzed.

3 ce whether the protein can be prenylated and proteolyzed.

4 rectly to the 26 S proteasome where they are proteolyzed.

5 d by cellular quality control systems and is proteolyzed.

6 in the endolysosomal pathway where MARCH1 is proteolyzed.

7 crystallin, since other crystallins were not proteolyzed.

8 ion of host targets that are inappropriately proteolyzed.

9 he catalytically potent MT1-MMP pool is self-proteolyzed.

10 in Escherichia coli, purified, and partially proteolyzed.

11 imately 100 kDa suggest that POLQ is readily proteolyzed.

12 how that, like human SPP, Drosophila SPP can proteolyze a model signal peptide and is sensitive to an

13 Unexpectedly, C1 failed to proteolyze a soluble recombinant SNAP-25, even though it

14 Both Afc1p and Rce1p were able to proteolyze a-factor with A, V, L, I, C, or M at the a(1)

15 multisubunit gamma-secretase complex, which proteolyzes a number of type I transmembrane proteins, i

16 alyzed by distinct protein components of the proteolyzed ACDS complex: (a) CO dehydrogenase, catalyze

17 In contrast, Afc1p was able to proteolyze additional a-factor variants that Rce1p may n

18 membrane protein T (OmpT) protease, tau was proteolyzed after lysis to a gamma-like protein, gammaP,

19 dly, the related protein HCF-2, which is not proteolyzed, also contains a functional SAS1 association

20 re- and thrombin-treated platelets contained proteolyzed and activated forms of the enzyme, indicatin

21 lier alpha1 PI-trypsin complex may have been proteolyzed and that the present structure is more likel

22 linker sequence between P1 and P2 is readily proteolyzed and the conserved arginines are solvent acce

23 Ultimately, Cim1 is rapidly and specifically proteolyzed as soybean cultures reach stationary phase.

24 MAG is proteolyzed at a discrete location near its transmembran

25 following gamma-secretase cleavage, Notch is proteolyzed at a novel S5 site.

26 strated that the PKC-phosphorylated form was proteolyzed at a significantly faster rate than the unph

27 When caspase-3 is activated, JNK1-2 is proteolyzed at Asp-385 increasing the release of cytochr

28 urified proteins, we showed that ADAMTS13 is proteolyzed at several cleavage sites by thrombin in a t

29 he cleaved receptor indicated that tie-1 was proteolyzed at the E749/S750 peptide bond in the proxima

30 Analysis of RGS2 mutants proteolyzed at various rates and the effects of proteaso

31 gest that the C-terminal telopeptide must be proteolyzed before collagenase can gain access to the cl

32 at lamin B is phosphorylated by PKCalpha and proteolyzed before DNA fragmentation in HL60 cells under

33 of young donors suggested that the rate that proteolyzed betaB1-crystallins become water-insoluble is

34 ra-axonal loop of the NaCh alpha-subunit was proteolyzed between 5 and 20 min after trauma.

35 ken blood and those reported for a partially proteolyzed bovine fibrinogen in the nature of twist in

36 pproximately 4-A resolution of a selectively proteolyzed bovine fibrinogen.

37 teolysis, demonstrate an independent pool of proteolyzed but nonmethylated lamin B1, as well as fully

38 GLUT1 was extensively proteolyzed by alpha-chymotrypsin, which cuts putative p

39 cadian oscillatory protein) and that SCOP is proteolyzed by calpain when hippocampal neurons are stim

40 d demonstrate that full-length human PRK2 is proteolyzed by caspase-3 at Asp117 and Asp700 in vitro.

41 Furthermore, MLH1 is rapidly proteolyzed by caspase-3 in cancer cells induced to unde

42 t IkappaB kinase (IKK) beta was specifically proteolyzed by Caspase-3-related caspases at aspartic ac

43 mately 47-kDa product, which is subsequently proteolyzed by caspases at Asp(1125) into an unstable 22

44 Moreover, we show that RAD21 is specifically proteolyzed by caspases into a similarly sized 65-kDa ca

45 CD2AP itself was proteolyzed by CatL, promoting sustained expression of t

46 e structural proteins of the granule are not proteolyzed by CGSP1.

47 Here we show that DrrB is proteolyzed by FtsH when it is expressed alone.

48 Here, we report that tau is proteolyzed by multiple caspases at a highly conserved a

49 lpha3 chain of laminin-5 can be specifically proteolyzed by plasmin to a 160-kD species at enzyme con

50 factor variants with a(1) substitutions were proteolyzed by Rce1p but not by Afc1p.

51 Whereas Hirudo synaptobrevin is proteolyzed by tetanus toxin, its SNAP-25 isoform is res

52 and strongly indicate that Notch and APP are proteolyzed by the same enzyme(s).

53 systematic assembly of fibrinogen molecules proteolyzed by thrombin.

54 tein of Mr = 25 000 (SNAP-25) is selectively proteolyzed by types A and E.

55 llowing IC50 cisplatin treatment, whereas no proteolyzed caspase-3 subunits were detected in the A278

56 d cells, or detergent extracts prepared from proteolyzed cells occurs only to the 85-92 kDa rLHR, the

57 binding to detergent extracts prepared from proteolyzed cells was largely preserved.

58 rison of the binding capacity of control and proteolyzed cells with that of their detergent extracts

59 del, suggesting that Ca(2+) leak through the proteolyzed channel may act as a feed-forward mechanism

60 age (MPhi) activation to a similar extent as proteolyzed chemerin, but exhibited reduced activity as

61 elastase (HNE) and free chymotrypsin (Chtr) proteolyze Chtr within the complex that Chtr forms with

62 s, and the matrix metalloproteinases that do proteolyze collagen are affected by the architecture of

63 Crystals of proteolyzed complex could be obtained that grew very slo

64 The analysis revealed that EP-B2 extensively proteolyzes complex gluten proteins in bread, whereas SC

65 reveal that highly metastatic tumors express proteolyzed cyclin E and FAK when compared to tumors wit

66 aled that two proteins, Nup153 and p62, were proteolyzed during poliovirus infection.

67 Cell-associated HK is proteolyzed during the course of prekallikrein activatio

68 liva augmented virus infectivity in vitro by proteolyzing extracellular matrix proteins, thereby incr

69 for macrophages in cell culture, suggesting proteolyzed fibrillar collagen as a candidate ECM mediat

70 y purified Drs2p associates primarily with a proteolyzed form of Drs2p lacking the C-terminal cytosol

71 We also show that a proteolyzed fragment of MotA that contains the C-termina

72 Complete sequences of the peptides proteolyzed from human articular cartilage, including N-

73 ubulin in which two hydrophobic residues are proteolyzed from the C-terminus, thus exposing a charged

74 rus must disassemble the immature lattice by proteolyzing Gag and then reassemble the key proteolytic

75 Taspase1 proenzyme is intramolecularly proteolyzed generating an active 28 kDa alpha/22 kDa bet

76 Calpain I proteolyzed GSK-3beta in vitro at C-terminus, leading to

77 However, binding of partially proteolyzed HeLa eIF3 to the eIF3-binding domain of huma

78 ed-sheet structure is usually formed only by proteolyzed HET-s(218-289), but intact HET-s(218-289) ca

79 ease in total IGFBP-3 levels and increase in proteolyzed IGFBP-3 in circulation when compared to thei

80 ated linker mutants of caspase-8 that can be proteolyzed in a controlled manner by thrombin or tobacc

81 induction of apoptosis, because p62 was not proteolyzed in apoptotic HeLa cells, and Nup153 was clea

82 We found that PKCeta is proteolyzed in apoptotic lymphocytes, generating a kinas

83 multiple cell cycle events, is specifically proteolyzed in cells preparing to initiate DNA replicati

84 roles in platelet functions, were partially proteolyzed in EHC Cosmc(-/y) platelets.

85 lecules were constitutively internalized and proteolyzed in lysosomes.

86 d that an increased amount of tyrosinase was proteolyzed in melan-p1 cells compared with wild-type me

87 I was then isolated from an SDS-PAGE gel and proteolyzed in situ with trypsin.

88 oposed oral therapies for celiac sprue) were proteolyzed in the absence or presence of a 10 mmol/L co

89 rdered tail in the full-length HasAp must be proteolyzed in the extracellular milieu to make HasAp a

90 EI-C is rapidly proteolyzed in vivo.

91 down-regulated, and the cyclin cig2p can be proteolyzed independently of rum1p.

92 tures of an immature VP70 virion and a fully proteolyzed, infectious virion.

93 The 30-kDa fragment is further proteolyzed into smaller fragments and retains the speci

94 Matrix metalloproteinase-2 proteolyzes intracellular proteins in the heart and indu

95 l-terminal peptide in FR-beta is efficiently proteolyzed intracellularly by a pathway that is indepen

96 city of reovirus outer capsid proteins to be proteolyzed is a determinant of cellular host range.

97 release and the ability of the neurotoxin to proteolyze its target protein and support the view that

98 actor XII generates plasma kallikrein, which proteolyzes kininogen, leading to the liberation of brad

99 f [(125)I]MFZ 2-24 incorporation achieved by proteolyzing labeled wild-type and methionine mutant DAT

100 STQ peptide selectively bound denatured and proteolyzed laminin but showed little interaction with n

101 (Ii) are targeted to endosomes, where Ii is proteolyzed, leaving remnant class II-associated Ii pept

102 Although alternatively proteolyzed legumin-type globulin polypeptides largely a

103 Analysis utilizing modeling of the proteolyzed loop and GlcN-Ins docking, as well as the ex

104 The proteolyzed microsomes were assayed for SRP-independent

105 ation after mechanical injury indicates that proteolyzed NaChs remain in the membrane before noticeab

106 Enteroviruses proteolyze nuclear pore complex (NPC) proteins (Nups) du

107 A proteolyzed nuclear extract was separated on the methyl-

108 failure of this peptide to be appropriately proteolyzed or transported.

109 -calpain required only 1 to 3 microM Ca2+ to proteolyze p53 in WI-38 cell lysates.

110 The resultant proteolyzed particles, unlike intact virions, have the c

111 Proteolyzed peptide products were identified by proteomi

112 Proteolyzed peptides provide the basis for mass-analyzed

113 threonine as the active site nucleophile to proteolyze polypeptide substrates following aspartate.

114 , a cardiac-specific myofilament protein, is proteolyzed post-MI in humans, which results in an N-ter

115 nvertases (furin, PACE-4, and PC-2) known to proteolyze proneurotrophins in vivo.

116 Trypsin-proteolyzed protein differed little from the intact prot

117 Surprisingly, the vast majority of proteolyzed proteins, regardless of the extent of cleava

118 The generation of proteolyzed prothrombin species by preassembled prothrom

119 Only proteolyzed PTPmu fragments are detected in human gliobl

120 ponding to the new amino terminal end of the proteolyzed seven-transmembrane domain thrombin receptor

121 In contrast, wild type rhodanese is not proteolyzed significantly under any of the experimental

122 nimally-processed emulsion was lipolyzed and proteolyzed slower than processed formulas.

123 89) can form stacked sheets when seeded with proteolyzed stacked-sheet HET-s(218-289).

124 Botulinum neurotoxin C1, which specifically proteolyzes syntaxin, or antibodies against syntaxin res

125 We further show that human PSA directly proteolyzes tau in vitro.

126 Protein sequencing of proteolyzed tetanus toxin C fragment co-migrating with t

127 BoNT/E is thought to selectively proteolyze the 25,000-dalton synaptosomal associated pro

128 improperly initiate chromosome replication, proteolyze the replication inhibitor CtrA, localize the

129 ecific interaction in the melting domain, we proteolyzed the cross-linked T7 RNAP and analyzed the fr

130 CatL proteolyzed the regulatory GTPase dynamin and the actin-

131 nel TRPC6, which activates host calpain that proteolyzes the host cytoskeleton allowing parasite rele

132 Mouse 3-OST cDNAs were isolated by proteolyzing the purified enzyme with Lys-C, sequencing

133 se only the mutant protein is quantitatively proteolyzed these data suggest that a post-ER quality co

134 Apart from identifying a function of proteolyzed thrombin and its fragments, our findings pro

135 Further, pro-caspase-3 at 32 kDa was proteolyzed to a fragment at 30 kDa, tau protein was los

136 ggregates as a full-length protein, becoming proteolyzed to a smaller fragment through a process requ

137 Moreover, spirals still form when dynamin is proteolyzed to either a predominant approximately 90-kDa

138 at only one of the catalytic domains must be proteolyzed to enable activation.

139 chymotrypsin, the outer capsid is completely proteolyzed to form cores.

140 at 30 kDa, tau protein was lost, and p35 was proteolyzed to p25 suggesting prolonged activation of cd

141 Gli2 and Gli3 are proteolyzed to produce a repressor form able to inhibit

142 Gag is then proteolyzed to produce the smaller capsid protein CA, wh

143 mino acid preproHNP(1-94), cotranslationally proteolyzed to proHNP(20-94), then converted by removal

144 ed as membrane-bound precursors that must be proteolyzed to release the transcriptionally active NH2-

145 hnRNP A1 can be proteolyzed to unwinding protein (UP1), a 22.1-kDa prote

146 The proteolyzed tyrosinase was no longer membrane bound, but

147 When Rpl23ab was proteolyzed, using proteinase ArgC or CNBr, and the pept

148 ight mass spectrometry studies of intact and proteolyzed vesicles from the cyanobacterium Anabaena fl

149 hibits mesotrypsin very weakly and is slowly proteolyzed, whereas, despite close sequence and structu

150 When tetanus toxin C fragment was proteolyzed with clostripain, whether before or after re

151 transport inside sensitive cells where it is proteolyzed with release of a toxic warhead-a nonhydroly

152 essing 6xHis-tagged ubiquitin were isolated, proteolyzed with trypsin and analyzed by multidimensiona

153 and membrane proteins of strain Rd KW20 were proteolyzed with trypsin and directly examined by LC-MS/

154 AR2CSA protein unless it was first partially proteolyzed with trypsin or chymotrypsin.

155 uilibration, rhodanese was not significantly proteolyzed with trypsin.

156 oxyl-terminal peptide was at least partially proteolyzed without GPI modification.