ライフサイエンスコーパス: proteolyze

1 actor variants that Rce1p may not be able to proteolyze.

2 ce whether the protein can be prenylated and proteolyzed.

3 rectly to the 26 S proteasome where they are proteolyzed.

4 d by cellular quality control systems and is proteolyzed.

5 in the endolysosomal pathway where MARCH1 is proteolyzed.

6 crystallin, since other crystallins were not proteolyzed.

7 ytic than chymosin and that kappa-casein was proteolyzed.

8 ion of host targets that are inappropriately proteolyzed.

9 he catalytically potent MT1-MMP pool is self-proteolyzed.

10 in Escherichia coli, purified, and partially proteolyzed.

11 imately 100 kDa suggest that POLQ is readily proteolyzed.

12 how that, like human SPP, Drosophila SPP can proteolyze a model signal peptide and is sensitive to an

13 Unexpectedly, C1 failed to proteolyze a soluble recombinant SNAP-25, even though it

14 Both Afc1p and Rce1p were able to proteolyze a-factor with A, V, L, I, C, or M at the a(1)

15 multisubunit gamma-secretase complex, which proteolyzes a number of type I transmembrane proteins, i

16 alyzed by distinct protein components of the proteolyzed ACDS complex: (a) CO dehydrogenase, catalyze

17 In contrast, Afc1p was able to proteolyze additional a-factor variants that Rce1p may n

18 membrane protein T (OmpT) protease, tau was proteolyzed after lysis to a gamma-like protein, gammaP,

19 dly, the related protein HCF-2, which is not proteolyzed, also contains a functional SAS1 association

20 reflect the ability of the 20S proteasome to proteolyze an isopeptide-linked ubiquitin-conjugate.

21 re- and thrombin-treated platelets contained proteolyzed and activated forms of the enzyme, indicatin

22 to isolate nanobodies distinguishing between proteolyzed and non-proteolyzed VWF, leading to the iden

23 lier alpha1 PI-trypsin complex may have been proteolyzed and that the present structure is more likel

24 linker sequence between P1 and P2 is readily proteolyzed and the conserved arginines are solvent acce

25 Ultimately, Cim1 is rapidly and specifically proteolyzed as soybean cultures reach stationary phase.

26 MAG is proteolyzed at a discrete location near its transmembran

27 following gamma-secretase cleavage, Notch is proteolyzed at a novel S5 site.

28 strated that the PKC-phosphorylated form was proteolyzed at a significantly faster rate than the unph

29 When caspase-3 is activated, JNK1-2 is proteolyzed at Asp-385 increasing the release of cytochr

30 urified proteins, we showed that ADAMTS13 is proteolyzed at several cleavage sites by thrombin in a t

31 he cleaved receptor indicated that tie-1 was proteolyzed at the E749/S750 peptide bond in the proxima

32 Analysis of RGS2 mutants proteolyzed at various rates and the effects of proteaso

33 gest that the C-terminal telopeptide must be proteolyzed before collagenase can gain access to the cl

34 at lamin B is phosphorylated by PKCalpha and proteolyzed before DNA fragmentation in HL60 cells under

35 of young donors suggested that the rate that proteolyzed betaB1-crystallins become water-insoluble is

36 ra-axonal loop of the NaCh alpha-subunit was proteolyzed between 5 and 20 min after trauma.

37 ken blood and those reported for a partially proteolyzed bovine fibrinogen in the nature of twist in

38 pproximately 4-A resolution of a selectively proteolyzed bovine fibrinogen.

39 teolysis, demonstrate an independent pool of proteolyzed but nonmethylated lamin B1, as well as fully

40 GLUT1 was extensively proteolyzed by alpha-chymotrypsin, which cuts putative p

41 cadian oscillatory protein) and that SCOP is proteolyzed by calpain when hippocampal neurons are stim

42 d demonstrate that full-length human PRK2 is proteolyzed by caspase-3 at Asp117 and Asp700 in vitro.

43 Furthermore, MLH1 is rapidly proteolyzed by caspase-3 in cancer cells induced to unde

44 t IkappaB kinase (IKK) beta was specifically proteolyzed by Caspase-3-related caspases at aspartic ac

45 mately 47-kDa product, which is subsequently proteolyzed by caspases at Asp(1125) into an unstable 22

46 Moreover, we show that RAD21 is specifically proteolyzed by caspases into a similarly sized 65-kDa ca

47 CD2AP itself was proteolyzed by CatL, promoting sustained expression of t

48 e structural proteins of the granule are not proteolyzed by CGSP1.

49 L were unaffected by trypsin but were slowly proteolyzed by chymotrypsin C.

50 Here we show that DrrB is proteolyzed by FtsH when it is expressed alone.

51 Here, we report that tau is proteolyzed by multiple caspases at a highly conserved a

52 lpha3 chain of laminin-5 can be specifically proteolyzed by plasmin to a 160-kD species at enzyme con

53 factor variants with a(1) substitutions were proteolyzed by Rce1p but not by Afc1p.

54 protein substrate that is site-specifically proteolyzed by RNA-activated Craspase.

55 Whereas Hirudo synaptobrevin is proteolyzed by tetanus toxin, its SNAP-25 isoform is res

56 and strongly indicate that Notch and APP are proteolyzed by the same enzyme(s).

57 systematic assembly of fibrinogen molecules proteolyzed by thrombin.

58 tein of Mr = 25 000 (SNAP-25) is selectively proteolyzed by types A and E.

59 llowing IC50 cisplatin treatment, whereas no proteolyzed caspase-3 subunits were detected in the A278

60 d cells, or detergent extracts prepared from proteolyzed cells occurs only to the 85-92 kDa rLHR, the

61 binding to detergent extracts prepared from proteolyzed cells was largely preserved.

62 rison of the binding capacity of control and proteolyzed cells with that of their detergent extracts

63 del, suggesting that Ca(2+) leak through the proteolyzed channel may act as a feed-forward mechanism

64 age (MPhi) activation to a similar extent as proteolyzed chemerin, but exhibited reduced activity as

65 elastase (HNE) and free chymotrypsin (Chtr) proteolyze Chtr within the complex that Chtr forms with

66 s, and the matrix metalloproteinases that do proteolyze collagen are affected by the architecture of

67 is using PET with a peptide tracer targeting proteolyzed collagen IV (T-peptide).

68 onclusion The T-peptide PET tracer targeting proteolyzed collagen IV provided a sensitive and specifi

69 Crystals of proteolyzed complex could be obtained that grew very slo

70 The analysis revealed that EP-B2 extensively proteolyzes complex gluten proteins in bread, whereas SC

71 reveal that highly metastatic tumors express proteolyzed cyclin E and FAK when compared to tumors wit

72 (SMAX1), a transcriptional repressor that is proteolyzed during karrikin signaling.

73 aled that two proteins, Nup153 and p62, were proteolyzed during poliovirus infection.

74 Cell-associated HK is proteolyzed during the course of prekallikrein activatio

75 liva augmented virus infectivity in vitro by proteolyzing extracellular matrix proteins, thereby incr

76 AGPCRs uniquely contain large, self-proteolyzing extracellular regions that range from hundr

77 for macrophages in cell culture, suggesting proteolyzed fibrillar collagen as a candidate ECM mediat

78 y purified Drs2p associates primarily with a proteolyzed form of Drs2p lacking the C-terminal cytosol

79 We also show that a proteolyzed fragment of MotA that contains the C-termina

80 Complete sequences of the peptides proteolyzed from human articular cartilage, including N-

81 ubulin in which two hydrophobic residues are proteolyzed from the C-terminus, thus exposing a charged

82 Finally, the ES is proteolyzed from the mature TcpF protein upon secretion.

83 rus must disassemble the immature lattice by proteolyzing Gag and then reassemble the key proteolytic

84 Taspase1 proenzyme is intramolecularly proteolyzed generating an active 28 kDa alpha/22 kDa bet

85 Calpain I proteolyzed GSK-3beta in vitro at C-terminus, leading to

86 However, binding of partially proteolyzed HeLa eIF3 to the eIF3-binding domain of huma

87 ed-sheet structure is usually formed only by proteolyzed HET-s(218-289), but intact HET-s(218-289) ca

88 ease in total IGFBP-3 levels and increase in proteolyzed IGFBP-3 in circulation when compared to thei

89 ated linker mutants of caspase-8 that can be proteolyzed in a controlled manner by thrombin or tobacc

90 induction of apoptosis, because p62 was not proteolyzed in apoptotic HeLa cells, and Nup153 was clea

91 We found that PKCeta is proteolyzed in apoptotic lymphocytes, generating a kinas

92 multiple cell cycle events, is specifically proteolyzed in cells preparing to initiate DNA replicati

93 Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRp

94 roles in platelet functions, were partially proteolyzed in EHC Cosmc(-/y) platelets.

95 lecules were constitutively internalized and proteolyzed in lysosomes.

96 d that an increased amount of tyrosinase was proteolyzed in melan-p1 cells compared with wild-type me

97 I was then isolated from an SDS-PAGE gel and proteolyzed in situ with trypsin.

98 oposed oral therapies for celiac sprue) were proteolyzed in the absence or presence of a 10 mmol/L co

99 rdered tail in the full-length HasAp must be proteolyzed in the extracellular milieu to make HasAp a

100 EI-C is rapidly proteolyzed in vivo.

101 down-regulated, and the cyclin cig2p can be proteolyzed independently of rum1p.

102 tures of an immature VP70 virion and a fully proteolyzed, infectious virion.

103 , the bottom-up approach, where proteins are proteolyzed into peptides, remains predominant due to th

104 The 30-kDa fragment is further proteolyzed into smaller fragments and retains the speci

105 Matrix metalloproteinase-2 proteolyzes intracellular proteins in the heart and indu

106 l-terminal peptide in FR-beta is efficiently proteolyzed intracellularly by a pathway that is indepen

107 city of reovirus outer capsid proteins to be proteolyzed is a determinant of cellular host range.

108 release and the ability of the neurotoxin to proteolyze its target protein and support the view that

109 actor XII generates plasma kallikrein, which proteolyzes kininogen, leading to the liberation of brad

110 f [(125)I]MFZ 2-24 incorporation achieved by proteolyzing labeled wild-type and methionine mutant DAT

111 STQ peptide selectively bound denatured and proteolyzed laminin but showed little interaction with n

112 (Ii) are targeted to endosomes, where Ii is proteolyzed, leaving remnant class II-associated Ii pept

113 Although alternatively proteolyzed legumin-type globulin polypeptides largely a

114 Analysis utilizing modeling of the proteolyzed loop and GlcN-Ins docking, as well as the ex

115 The proteolyzed microsomes were assayed for SRP-independent

116 ation after mechanical injury indicates that proteolyzed NaChs remain in the membrane before noticeab

117 Enteroviruses proteolyze nuclear pore complex (NPC) proteins (Nups) du

118 A proteolyzed nuclear extract was separated on the methyl-

119 failure of this peptide to be appropriately proteolyzed or transported.

120 -calpain required only 1 to 3 microM Ca2+ to proteolyze p53 in WI-38 cell lysates.

121 The resultant proteolyzed particles, unlike intact virions, have the c

122 Proteolyzed peptide products were identified by proteomi

123 Proteolyzed peptides provide the basis for mass-analyzed

124 ingle amino acid change slows degradation of proteolyzed PINK1, increasing its accumulation at the ou

125 threonine as the active site nucleophile to proteolyze polypeptide substrates following aspartate.

126 , a cardiac-specific myofilament protein, is proteolyzed post-MI in humans, which results in an N-ter

127 However, APP substrate is proteolyzed processively by y-secretase along two pathwa

128 nvertases (furin, PACE-4, and PC-2) known to proteolyze proneurotrophins in vivo.

129 Trypsin-proteolyzed protein differed little from the intact prot

130 Surprisingly, the vast majority of proteolyzed proteins, regardless of the extent of cleava

131 The generation of proteolyzed prothrombin species by preassembled prothrom

132 Only proteolyzed PTPmu fragments are detected in human gliobl

133 ponding to the new amino terminal end of the proteolyzed seven-transmembrane domain thrombin receptor

134 In contrast, wild type rhodanese is not proteolyzed significantly under any of the experimental

135 nimally-processed emulsion was lipolyzed and proteolyzed slower than processed formulas.

136 89) can form stacked sheets when seeded with proteolyzed stacked-sheet HET-s(218-289).

137 Botulinum neurotoxin C1, which specifically proteolyzes syntaxin, or antibodies against syntaxin res

138 We further show that human PSA directly proteolyzes tau in vitro.

139 Protein sequencing of proteolyzed tetanus toxin C fragment co-migrating with t

140 BoNT/E is thought to selectively proteolyze the 25,000-dalton synaptosomal associated pro

141 improperly initiate chromosome replication, proteolyze the replication inhibitor CtrA, localize the

142 ecific interaction in the melting domain, we proteolyzed the cross-linked T7 RNAP and analyzed the fr

143 In vitro, the R227W mutant HTRA1 efficiently proteolyzed the disordered substrate casein but not aggr

144 CatL proteolyzed the regulatory GTPase dynamin and the actin-

145 nel TRPC6, which activates host calpain that proteolyzes the host cytoskeleton allowing parasite rele

146 Mouse 3-OST cDNAs were isolated by proteolyzing the purified enzyme with Lys-C, sequencing

147 se only the mutant protein is quantitatively proteolyzed these data suggest that a post-ER quality co

148 Apart from identifying a function of proteolyzed thrombin and its fragments, our findings pro

149 Further, pro-caspase-3 at 32 kDa was proteolyzed to a fragment at 30 kDa, tau protein was los

150 ggregates as a full-length protein, becoming proteolyzed to a smaller fragment through a process requ

151 ted and cyclized concatemeric repeat is then proteolyzed to afford OF4949.

152 Moreover, spirals still form when dynamin is proteolyzed to either a predominant approximately 90-kDa

153 at only one of the catalytic domains must be proteolyzed to enable activation.

154 chymotrypsin, the outer capsid is completely proteolyzed to form cores.

155 at 30 kDa, tau protein was lost, and p35 was proteolyzed to p25 suggesting prolonged activation of cd

156 Gli2 and Gli3 are proteolyzed to produce a repressor form able to inhibit

157 Gag is then proteolyzed to produce the smaller capsid protein CA, wh

158 mino acid preproHNP(1-94), cotranslationally proteolyzed to proHNP(20-94), then converted by removal

159 ed as membrane-bound precursors that must be proteolyzed to release the transcriptionally active NH2-

160 hnRNP A1 can be proteolyzed to unwinding protein (UP1), a 22.1-kDa prote

161 The proteolyzed tyrosinase was no longer membrane bound, but

162 in cooperation with p97 and Ufd1-Npl4, SPRTN proteolyzed unfolded Eos-DPC, which relied on recognitio

163 When Rpl23ab was proteolyzed, using proteinase ArgC or CNBr, and the pept

164 and tetanus neurotoxins, which specifically proteolyze vesicle fusion proteins involved in regulated

165 ight mass spectrometry studies of intact and proteolyzed vesicles from the cyanobacterium Anabaena fl

166 cute respiratory syndrome (SARS) coronavirus proteolyzes viral polyproteins and has been a target for

167 s distinguishing between proteolyzed and non-proteolyzed VWF, leading to the identification of a nano

168 hibits mesotrypsin very weakly and is slowly proteolyzed, whereas, despite close sequence and structu

169 When tetanus toxin C fragment was proteolyzed with clostripain, whether before or after re

170 e extracted by immunomagnetic separation and proteolyzed with pepsin yielding a phosphylated nonapept

171 transport inside sensitive cells where it is proteolyzed with release of a toxic warhead-a nonhydroly

172 essing 6xHis-tagged ubiquitin were isolated, proteolyzed with trypsin and analyzed by multidimensiona

173 and membrane proteins of strain Rd KW20 were proteolyzed with trypsin and directly examined by LC-MS/

174 AR2CSA protein unless it was first partially proteolyzed with trypsin or chymotrypsin.

175 In the second approach, 6aJL2 protein was proteolyzed with trypsin, and the products incubated in

176 uilibration, rhodanese was not significantly proteolyzed with trypsin.

177 oxyl-terminal peptide was at least partially proteolyzed without GPI modification.