ライフサイエンスコーパス: prothrombin time

1 ed by the international normalized ratio for prothrombin time).

2 brain "thromboplastic" activity used in the prothrombin time.

3 eserves normal liver function as assessed by prothrombin time.

4 candidacy for liver transplant and prolonged prothrombin time.

5 m: age, Glasgow Coma Scale, base excess, and prothrombin time.

6 or Xa inhibitor which has a strong impact on prothrombin time.

7 d the international normalized ratio for the prothrombin time.

8 nogen at the time of surgery, with unchanged prothrombin time.

9 rked thrombocytopenia or prolongation in the prothrombin time.

10 g activated partial thromboplastin times and prothrombin times.

11 irect bilirubin (0.13 versus 0.1, P = 0.01), prothrombin time (14.4 versus 12.4, P = 0.002), and AST-

12 ssue factor; 60 nM lactadherin prolonged the prothrombin time 150% versus 20% for 60 nM annexin V.

13 ificantly decreased in the small group, with prothrombin time 18.2 +/- 2.2 seconds versus 14.8 +/- 1.

14 had ascites (91%), jaundice (88%), elevated prothrombin time (18 +/- 3 seconds), and hypoalbuminemia

15 nd 2.3 [0.8-8.7] microg/mL, p = .05), longer prothrombin time (19.3 [15.4-25.9] vs. 15.3 [14.8-17.1],

16 d heparin followed by warfarin for 3 months (prothrombin time, 20 to 25 seconds).

17 >5 weeks after onset; P < .01), more severe prothrombin time abnormalities (26% vs. 0% with >3 secon

18 C was confirmed within 4 hours by changes in prothrombin time, activated partial thromboplastin time,

19 unction was assessed by thrombin generation, prothrombin time, activated partial thromboplastin time,

20 thological grades, total bilirubin, albumin, prothrombin time, alpha-fetoprotein, and tumor number, w

21 S) status, ABO blood group, bilirubin level, prothrombin time, ammonia level, creatinine level, and r

22 ere present in the patient's plasma and both prothrombin time and activated partial thromboplastin ti

23 ory studies demonstrated prolongation of the prothrombin time and activated partial thromboplastin ti

24 s prothrombinase activity and increases both prothrombin time and activated partial thromboplastin ti

25 The mutant was inactive in both prothrombin time and activated partial thromboplastin ti

26 Laboratory findings (such as prothrombin time and bilirubin level), complications, an

27 and absolute lymphocyte counts and increased prothrombin time and creatinine and amylase levels.

28 Knockout FVII mice demonstrated a delayed prothrombin time and decreased plasma FVII expression.

29 Prothrombin time and INR were measured before and after

30 varices demonstrated a significantly longer prothrombin time and lower platelet count, there was no

31 d patients had more severe injury, prolonged prothrombin time and partial thromboplastin time (PTT),

32 y 3% of normal clotting activity in modified prothrombin time and partial thromboplastin time assays,

33 ase, and cholesterol levels were normal, but prothrombin time and partial thromboplastin time were pr

34 ransplanted baboons (high D-dimer, prolonged prothrombin time and partial thromboplastin time, and fa

35 area, preoperative hematocrit, preoperative prothrombin time and prior myocardial infarction.

36 er 90%, whereas fVII knockdown prolonged the prothrombin time and reduced fVII activity to a similar

37 alth Evaluation II score, modified MODS, and prothrombin time and the lowest platelet counts, whereas

38 re statistically similar with regard to age, prothrombin time and total bilirubin.

39 olongation of the partial thromboplastin and prothrombin times and hyperfibrinolysis with low levels

40 Lupus anticoagulants can influence prothrombin times and lead to INRs that do not accuratel

41 try (glucose, lactate, liver function tests, prothrombin time) and to assess liver regenerative respo

42 ther thrombocytopenia or prolongation of the prothrombin time, and (3) the resources used for large-v

43 fferences including plasma fibrinogen level, prothrombin time, and activated partial thromboplastin t

44 levels, admission lactate levels, platelets, prothrombin time, and activated partial thromboplastin t

45 rotein extracts were used for Western blots, prothrombin time, and activated partial thromboplastin t

46 ine aminotransferase, lactate dehydrogenase, prothrombin time, and alkaline phosphatase, with grafts

47 or age, gender, total bilirubin, creatinine, prothrombin time, and diagnosis.

48 ls, International Normalized Ratio (INR) for prothrombin time, and etiology of liver disease.

49 se patient participation, self-monitoring of prothrombin time, and guideline-based management of warf

50 Mean activated partial thromboplastin time, prothrombin time, and international normalized ratio wer

51 Serum albumin, prothrombin time, and platelet count at presentation wer

52 , D-dimer, alpha-2-antiplasmin, antitrombin, prothrombin time, and platelet count) and the DIC score

53 , sex, underlying liver disease, hemoglobin, prothrombin time, and platelet count.

54 d include serum acetaminophen concentration, prothrombin time, and serum bilirubin and transaminase c

55 story model, namely age, bilirubin, albumin, prothrombin time, and the presence or absence of edema.

56 th a relatively modest 1.25-fold increase in prothrombin times, and in the absence of hemorrhagic com

57 irubin, albumin, creatinine, and hemoglobin; prothrombin time; and numbers of platelets and white cel

58 ne aminotransferase (AST/ALT), and prolonged prothrombin time are the earliest indicators of cirrhosi

59 h as endotoxin-induced whole blood clotting, prothrombin time, as well as factor X and factor IX acti

60 ffective inhibitor of a modified whole blood prothrombin time assay in which clotting was initiated b

61 ivated protein C (APC):protein S in modified prothrombin time assays, the effects of depleting endoge

62 inverse correlation with platelet count and prothrombin time but not with serum albumin level.

63 r months to years, to maintain a near-normal prothrombin time can reverse the coagulopathy associated

64 ed activated partial thromboplastin time and prothrombin time clotting times to baseline at 60 mins.

65 protein S anticoagulant activity in modified prothrombin-time clotting assays.

66 asminogen activator inhibitor-1 activity and prothrombin time compared to children with MOF without t

67 control of ascites, level of encephalopathy, prothrombin time, concentration of serum albumin, and co

68 e, grade of encephalopathy, serum bilirubin, prothrombin time, creatinine, serum phosphorus, phosphor

69 cipient mechanical ventilation, preoperative prothrombin time, donor sodium level, donor length of ho

70 f seven serine proteases, and FVII-deficient prothrombin time EC2x = 1.2 muM.

71 sly unrecognized findings included prolonged prothrombin times, elevated platelet counts and serum ph

72 A combination of prothrombin time, endothelium-derived CD105-microparticl

73 markers for liver function are bilirubin and prothrombin time expressed as International Normalized R

74 survival was independently predicted by PS, prothrombin time, extrahepatic tumor spread, macrovascul

75 othrombin were altered by this treatment but prothrombin times, factor VII activity, prothrombin F-1

76 thod affected only by factors II and X (Fiix-prothrombin time [Fiix-PT]) compared with standard PT-IN

77 s thrombin potential and partial reversal of prothrombin time following 50 IU/kg.

78 r = 2 mg/dL, Glasgow Coma Score less than 6, prothrombin time greater than 15 seconds, blood urea nit

79 el greater than or equal to 250 mumol/L, and prothrombin time greater than or equal to 30 seconds was

80 tory insufficiency, age > or = 65 years, and prothrombin time > or = 16 seconds.

81 patients (26%) presented with coagulopathy (prothrombin time > or = 3 seconds prolonged).

82 an absolute platelet count <100 x 10/L; b) a prothrombin time >15.0 secs; c) a 20% decrease in platel

83 he use of sensitive reagents (especially for prothrombin time) has resulted in increased incidence of

84 ody mass index (HR 1.40; 95% CI: 1.01-1.95), prothrombin time (HR 0.79; 95% CI: 0.70-0.90), serum alb

85 Prothrombin time improved to normal in all patients 1 ye

86 actors, and treatment of prolongation of the prothrombin time in critically ill patients using the in

87 in platelets; and d) a >0.3-sec increase in prothrombin time in predicting outcome in patients with

88 ma activated partial thromboplastin time and prothrombin time increased over 10-fold during the bleed

89 eatinine, international normalized ratio for prothrombin time (INR), and the cause of the underlying

90 had hepatic encephalopathy; median levels of prothrombin time, INR, and total bilirubin were, respect

91 fact that screening coagulation tests (APTT, prothrombin time--INR) are often used as though they are

92 Prothrombin time international normalized ratio (INR) wa

93 owed that patient age older than 65 years, a prothrombin time international normalized ratio greater

94 rats had significantly lower blood ammonia, prothrombin time, international normalized ratio, and TG

95 , specifically baseline levels of bilirubin, prothrombin time/international normalized ratio, and Mod

96 Use of the INR to standardize prothrombin times is invalid for some patients with lupu

97 clotting test with the quick clotting time (prothrombin time), it was possible to diagnose factor VI

98 inemia, decreased serum fibrinogen, elevated prothrombin time), lactic acidosis, and hepatic steatosi

99 e influence of several anticoagulants on the prothrombin time limits its diagnostic value.

100 teristics, the most important being a higher prothrombin time, lower bilirubin, and lower incidence o

101 fined according to the "50-50 criteria" (ie, prothrombin time <50% and serum bilirubin >50 micromol/L

102 /= 127 g/L; odds ratio, 0.99; p < 0.01), and prothrombin time (</= 58%; odds ratio, 0.98; p < 0.05) w

103 We analyzed altered prothrombin time (measured as international normalized r

104 tment of warfarin treatment using a portable prothrombin time monitor may be effective and safe.

105 The results of prothrombin time monitoring should be reported as the In

106 factors that influence dosing, conscientious prothrombin time monitoring, and sage dosage adjustment

107 ially bleeding), inconveniences (the cost of prothrombin time monitoring, the need for rigid dietary

108 notransferase (ALT), albumin, bilirubin, and prothrombin time normalized in 76%, 81%, 50%, and 83% of

109 rtate aminotransferase, cholinesterases, and prothrombin time not differed in 2 groups.

110 hromboplastin time of 49.2 seconds, a normal prothrombin time of 12.4 seconds, and a platelet count o

111 mg/dL, alanine aminotransferase of 106 IU/L, prothrombin time of 14.2 sec, and serum albumin of 2.9 g

112 lation panel was unremarkable and included a prothrombin time of 15.4 seconds, an international norma

113 s of liver disease (P = 0.01) and a pre-TIPS prothrombin time of 17 seconds or more (P = 0.016).

114 -183X also had a maximal prolongation of the prothrombin time of 7.6- versus 1.9-fold for A-183, maki

115 national normalized ratio of more than 11, a prothrombin time of more than 120 seconds, and an activa

116 Mean prothrombin time on postoperative day 2 was 14.9 +/- 1.6

117 times are best suited for dabigatran and the prothrombin time or the anti-FXa for rivaroxaban.

118 states that routine correction of prolonged prothrombin time or thrombocytopenia is not required is

119 ndex (p < .02), Lung Injury Score (p < .02), prothrombin time (p < .02), and activated partial thromb

120 0.0001), alkaline phosphatase (P = 0.0009), prothrombin time (P = 0.0005), and maximal vital capacit

121 h baseline esophageal varices (P = 0.01) and prothrombin time (P = 0.002), but not with disease progr

122 wer serum albumin levels (P=0.04) and higher prothrombin times (P<0.001) at presentation.

123 Prolonged prothrombin time, partial activated thromboplastin time,

124 agulation changes were assessed by prolonged prothrombin time, partial activated thromboplastin time,

125 on of cFVIIa resulted in a shortening of the prothrombin time, partial correction of the whole blood

126 ate aminotransferase) and coagulation times (prothrombin time, partial thromboplastin time) indicated

127 were no differences in thrombin generation, prothrombin time, partial thromboplastin time, activated

128 of fibrinogen and platelets and increases of prothrombin time, partial thromboplastin time, and fibri

129 ly obtained measurements of laboratory-based prothrombin time, partial thromboplastin time, complete

130 Platelet counts, with plasma prothrombin time, partial thromboplastin time, fibrinoge

131 iabetes mellitus, relative lymphocyte count, prothrombin time, peripheral artery disease, and contral

132 emia, renal insufficiency, hyponatremia, and prothrombin time prolongation (all P < 0.001).

133 Prothrombin time prolongation is prevalent in critically

134 l for analysis of partial thromboplastin and prothrombin times, prothrombin fragments 1+2, fibrinogen

135 ce antigen positive, grade 1 encephalopathy, prothrombin time (pt) >100 sec, F7<1%, NH3 150 micromol/

136 Coagulation studies revealed prothrombin time (PT) 13.5 seconds, internationalized no

137 The low hemolysis of 2.39% with short prothrombin time (PT) and activated partial thromboplast

138 ale was referred for evaluation of prolonged prothrombin time (PT) and activated partial thromboplast

139 Increases in prothrombin time (PT) and international normalised ratio

140 Prothrombin time (PT) and the associated international n

141 Primary end points were changes in the prothrombin time (PT) and the partial thromboplastin tim

142 vated partial thromboplastin time (aPTT) and prothrombin time (PT) are clinical tests commonly used t

143 Cirrhotic patients with a prolonged prothrombin time (PT) are known to have low levels of fa

144 vated partial thromboplastin time (APTT) and prothrombin time (PT) are less sensitive and may be norm

145 rs of TF-dependent clotting as measured in a prothrombin time (PT) clotting assay and had no effect o

146 hTFAA prolongs prothrombin time (PT) determined with human plasma and r

147 /dL, platelet count less than 100000/microL, prothrombin time (PT) greater than or equal to 16 second

148 neral overview of the plasmatic coagulation, prothrombin time (PT) tests are frequently combined with

149 se [AST] and alanine transaminase [ALT]) and prothrombin time (PT) values achieved by each patient du

150 itial levels of albumin, platelet count, and prothrombin time (PT) were predictive risk factors for d

151 patient, whole blood lactate concentration, prothrombin time (PT), and alanine aminotransferase (ALT

152 nged the partial thromboplastin time (APTT), prothrombin time (PT), and bleeding time (BT).

153 Prothrombin time (PT), partial thromboplastin time (PTT)

154 , in addition to donor age, total bilirubin, prothrombin time (PT), retransplantation, and warm and c

155 Prothrombin time (PT), total bilirubin, serum ammonia, a

156 e (MA), LY30] with their corresponding CCTs [prothrombin time (PT)/activated partial thromboplastin t

157 er, there was no difference in elevations of prothrombin times (PT) or improvement in the vasoconstri

158 Platelet counts, prothrombin times (PT), and levels of fibrinogen, D-dime

159 ongly with anti-factor Xa activity (r=0.97), prothrombin time (r=0.77), and international normalized

160 were recruited within 72 hours of their peak prothrombin time (range 42-120 seconds).

161 nsfusion (detection rate of 71%, vs. 43% for prothrombin time ratio >1.2, p < .001).

162 traumatic coagulopathy defined as laboratory prothrombin time ratio >1.2.

163 Point-of-care prothrombin time ratio had reduced agreement with labora

164 ratio had reduced agreement with laboratory prothrombin time ratio in patients with acute traumatic

165 In trauma hemorrhage, prothrombin time ratio is not rapidly available from the

166 coagulation therapy and the deviation in the prothrombin time ratio using Cox and Poisson regression,

167 Prothrombin time ratio was calculated and acute traumati

168 coagulation therapy and the deviation in the prothrombin time ratio were much stronger predictors of

169 to the mean warfarin dose and dose-adjusted prothrombin time ratio.

170 rtial thromboplastin time (aPTT) reagent and prothrombin time reagent and reduces the anticoagulant e

171 As anticipated, prothrombin time remained unchanged compared with baseli

172 Laboratory prothrombin time results were available at a median of 7

173 c transaminase (U/L), bilirubin (mg/dL), and prothrombin time (sec) during the first postoperative we

174 rats resulted in significant improvement in prothrombin time, serum albumin and bilirubin levels, he

175 flected by changes in the platelet count and prothrombin time that convey prognostic information.

176 ximum amplitude to 75% +/- 3%; and prolonged prothrombin time to 113% +/- 2%, partial thromboplastin

177 available (international normalized ratio of prothrombin time, total bilirubin, and creatinine).

178 ith CO maintained liver function with normal prothrombin times versus a 2-fold prolongation in contro

179 dure mean international normalized ratio for prothrombin time was 1.7 +/- 0.46 (range, 0.9-8.7; inter

180 Postoperative day 2 prothrombin time was 13+/-1 sec.

181 Baseline prothrombin time was 28+/-0.8 secs (n=8) and followed a

182 the international normalized ratio (INR) of prothrombin time was available, MELD correlated with out

183 Mean prothrombin time was shorter in arterial strokes (P < .0

184 olongation of the partial thromboplastin and prothrombin times was only observed with an increased BD

185 otransferase, aspartate aminotransferase,and prothrombin time were not significantly different over t

186 Effects on prothrombin time were partially reversed at 50 IU/kg.

187 Activated partial thromboplastin time and prothrombin time were shortened by these proteinases, wi

188 acetaminophen self-poisoning and a prolonged prothrombin time were studied.

189 Prothrombin times were determined by using several throm

190 um aminotransferase and bilirubin levels and prothrombin times were higher in recipients of older tha

191 nfected mice compared with controls, whereas prothrombin times were normal, suggesting an isolated ab

192 All prothrombin times were normalized within 4 days of trans

193 icoagulants who were not receiving warfarin, prothrombin times were often elevated and varied signifi

194 lupus anticoagulants often have a prolonged prothrombin time, which may complicate management of ant