ライフサイエンスコーパス: protocadherin

1 etalloproteinase, hemicentin, and a fat-like protocadherin).

2 Here we describe recent studies of the Fat1 protocadherin.

3 hat harbours the av mutation encodes a novel protocadherin.

4 neurons exhibit signal for subsets of delta-protocadherins.

5 ly of "nonclassic cadherin" genes designated protocadherins.

6 poER2; refs 9-11 ), alpha3beta1 integrin and protocadherins.

7 including the large family of cadherins and protocadherins.

8 We report here that protocadherin 10 (Pcdh10), an autism-spectrum disorders

9 eletions implicated genes, including PCDH10 (protocadherin 10) and DIA1 (deleted in autism1, or c3orf

10 Protocadherin-10 (Pcdh10) is an adhesion molecule found

11 nked proteins important in brain development-protocadherin 11 Y-linked (PCDH11Y) and neuroligin 4 Y-l

12 These genes include protocadherin 12 (Pcdh12), an ortholog of the mouse vasc

13 rmed by a tetramer of two cadherin proteins: protocadherin 15 (PCDH15) and cadherin 23 (CDH23), which

14 ents that consist of cadherin 23 (CDH23) and protocadherin 15 (PCDH15) and connect the stereocilia of

15 iated with deafness and hair bundle defects, protocadherin 15 (PCDH15) and myosin VIIa (MYO7A), into

16 e a static composition of the tip link, with protocadherin 15 (PCDH15) at the lower and cadherin 23 (

17 Here we report two mutations of protocadherin 15 (PCDH15) found in two families segregat

18 The tip link protein protocadherin 15 (PCDH15) is a central component of the

19 Protocadherin 15 (PCDH15) is expressed in hair cells of

20 Protocadherin 15 (PCDH15) is required for mechanotransdu

21 hair cells show that cadherin 23 (CDH23) and protocadherin 15 (PCDH15) localize to the upper and lowe

22 mains of cadherin 23 (CDH23), which binds to protocadherin 15 (PCDH15) to form tip links of mechanose

23 c hearing loss and an associated mutation in protocadherin 15 (Pcdh15), the Ames waltzer mice have be

24 One component of tip links is Protocadherin 15 (PCDH15).

25 ts formed by two atypical cadherins known as protocadherin 15 and cadherin 23 (refs 4, 5).

26 In humans, mutations in protocadherin 15 are known to result in Usher Syndrome t

27 utations in genes coding for cadherin 23 and protocadherin 15 cause deafness in both mice and humans.

28 full-length proteins; HCN1 can interact with protocadherin 15 CD3 and F-actin-binding filamin A formi

29 interact with HCN2 forming a complex without protocadherin 15 CD3 but including F-actin-binding fasci

30 ding sites for HCN1, with binding of HCN1 to protocadherin 15 CD3 favored between 26.5 and 68 microm

31 t interaction of the organ of Corti HCN1 and protocadherin 15 CD3 is mediated by amino-terminal seque

32 Binding by deletion mutants of protocadherin 15 CD3 pointed to amino acids 158-179 (Gen

33 calcium chelators, binding between HCN1 and protocadherin 15 CD3 was characterized by a K(D) = 2.39

34 Specific binding between HCN1 and protocadherin 15 CD3 was confirmed with pull-down assays

35 nteraction between HCN1 and tip-link protein protocadherin 15 CD3, a protein-protein interaction for

36 id analysis to bind the carboxyl terminus of protocadherin 15 CD3, a tip link protein implicated in m

37 [Ca(2+)] than for the HCN1 interaction with protocadherin 15 CD3.

38 We originally showed that the protocadherin 15 gene (Pcdh15) is necessary for hearing

39 rom our study show that both mouse and human protocadherin 15 genes have complex genomic structures a

40 ween HCN1 and stereociliary tip-link protein protocadherin 15 has been described for a teleost vestib

41 results further strengthen the importance of protocadherin 15 in the morphogenesis and cohesion of st

42 The protocadherin 15 labeling pattern with antisera PB303 in

43 We localized protocadherin 15 to inner ear hair cell stereocilia, and

44 e and nonsense mutations of PCDH15, encoding protocadherin 15, are known to cause deafness and retini

45 Mutations of PCDH15, the gene encoding protocadherin 15, cause either nonsyndromic deafness DFN

46 and binding experiments to characterize the protocadherin 15-cadherin 23 bond.

47 -terminal domains of cadherin-23 (CDH23) and protocadherin-15 (PCDH15).

48 outer-segment membrane by links composed of protocadherin-15 (USH1F protein).

49 ction channels, is composed of two proteins, protocadherin-15 and cadherin-23, whose mutation causes

50 Protocadherin-15 deficiency, obtained by a knockdown app

51 resent the X-ray crystal structures of human protocadherin-15 EC8-EC10 and mouse EC9-EC10, which show

52 Cadherin-23 and protocadherin-15 form tip links through a calcium-depend

53 Protocadherin-15 is therefore associated with the tip-li

54 ow cadherin-23 may bind with itself and with protocadherin-15 to form the tip link.

55 Multiple protocadherin-15 transcripts are shown to be expressed i

56 The new structure provides a first view of protocadherin-15's non-canonical EC linkers and suggests

57 LHFPL5 and TMC1 were shown to interact with protocadherin-15, a component of the tip link, which app

58 rs in the eye, as an avian ortholog of human protocadherin-15, a product of the gene for the deaf/bli

59 proteins-myosin VIIa, harmonin, cadherin-23, protocadherin-15, sans-do not display retinal degenerati

60 ced F-actin content in rods, suggesting that protocadherin-15-containing links are essential for thei

61 , physically interacts with tip link protein protocadherin-15.

62 to the comparable region in trout hair cell protocadherin 15a-like protein, as necessary for binding

63 he cytoplasmic carboxyl-terminal domain of a protocadherin 15a-like protein.

64 distribution expected for tip link sites of protocadherin 15a.

65 d 32 056 controls) revealing brain expressed protocadherin 17 (PCDH17) as a susceptibility gene for m

66 Protocadherin 17 (PCDH17), a neuronal cell adhesion mole

67 in the fish brain, with protocadherin-19 and protocadherin-17 showing much wider and stronger express

68 ession of three cadherins, protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brai

69 otor nuclei) contain protocadherin-19 and/or protocadherin-17-expressing cell.

70 Both protocadherin-19 and protocadherin-17-expressing cells occur throughout the b

71 Protocadherin-18a (Pcdh18a) belongs to the delta 2-proto

72 In this study, we demonstrate that pcdh 19 (protocadherin 19) acts synergistically with n-cadherin (

73 hanism of adhesion, mediated by a complex of Protocadherin-19 (Pcdh19) and N-cadherin (Ncad).

74 Mutations in the X-linked gene Protocadherin-19 (Pcdh19) cause female-limited epilepsy

75 s genetic studies revealed that mutations in protocadherin-19 (Pcdh19) lead to an epilepsy syndrome w

76 Mutations in protocadherin-19 (PCDH19) result in a female-limited, in

77 t expression pattern in the fish brain, with protocadherin-19 and protocadherin-17 showing much wider

78 Both protocadherin-19 and protocadherin-17-expressing cells o

79 r, abducens, and vagal motor nuclei) contain protocadherin-19 and/or protocadherin-17-expressing cell

80 Interference with Protocadherin-19 function with antisense morpholino olig

81 We have identified the zebrafish homolog of protocadherin-19, a member of the cadherin superfamily,

82 esults provide the first functional data for protocadherin-19, demonstrating an essential role in ear

83 examine mRNA expression of three cadherins, protocadherin-19, protocadherin-17, and cadherin-6 in ad

84 herin 7, contactin 3, netrin G2, cadherin 6, protocadherin 20, retinoid-related orphan receptor beta,

85 on studies showed that PROM1 interacted with protocadherin 21 (PCDH21), a photoreceptor-specific cadh

86 Intermicrovillar links are composed of protocadherin-24 and mucin-like protocadherin, which tar

87 d mouse breast and lung cancer cells express protocadherin 7 (PCDH7), which promotes the assembly of

88 14, located next to the region harboring the protocadherin 7 gene, PCDH7.

89 ed including Secreted Frizzled, cadherin 13, protocadherin 7, CCAAT/enhancer-binding protein-beta and

90 Here we show that protocadherin-8 (PCDH8), the human ortholog of PAPC, is

91 stent with the structural characteristics of protocadherins, a large first exon encodes the extracell

92 on profiles are observed for all eight delta-protocadherins along the dorsoventral, mediolateral, and

93 show that conditional deletion of the mouse protocadherin alpha (Pcdhalpha) gene cluster in serotone

94 large tandem-arrayed gene family, the human protocadherin alpha cluster, on chromosome 5.

95 P-containing loss-of-function alleles in the protocadherin alpha, beta and gamma gene clusters (Pcdha

96 The genomic organization of the human protocadherin alpha, beta, and gamma gene clusters (desi

97 as gene promoters, particularly those of the protocadherin alpha, beta, and gamma gene families.

98 WS) locus on chromosome 7 and genes from the protocadherin-alpha and -beta clusters.

99 oteins PCDH-J and FAT-J were classified into protocadherin and FAT-like subfamilies, respectively, ba

100 y curated protein-coding genes including the protocadherin and interleukin gene families.

101 Two of these, PCDH18 and PCDH19, are novel protocadherins and a third is the human orthologue of mo

102 o at certain monoallelic neural genes (e.g., protocadherins and olfactory receptors).

103 the seven-helix membrane cadherins, Fat-like protocadherins and the Ret-like cadherins.

104 termined the genomic structure of this novel protocadherin, and found a single-base deletion in exon

105 matrix metalloproteinase, CDH-3, a Fat-like protocadherin, and hemicentin, a fibulin family extracel

106 een identified to date (N-cadherin, paraxial protocadherin, and VN-cadherin).

107 proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, a

108 This report shows that protocadherins are essential for maintenance of normal r

109 Proteins called gamma-protocadherins are essential for the establishment of wo

110 Additionally, zebrafish protocadherins are far more prone to homogenizing gene c

111 Non-clustered delta-protocadherins are homophilic cell adhesion molecules es

112 Protocadherins are members of a nonclassic subfamily of

113 Protocadherins are members of the cadherin superfamily o

114 The protocadherins are the largest subgroup within this supe

115 We have identified a new subclass of protocadherins based on a shared and highly conserved 17

116 ial cells shape apical specializations using protocadherin-based adhesion.

117 a subgroup of the cadherin superfamily, the protocadherin beta (Pcdhbeta) cluster, was up-regulated

118 We show that loss of the apically localized protocadherin Cad99C rescues the SG defects, suggesting

119 In contrast to the two protocadherins, cadherin-6 expression is much weaker and

120 re transcriptionally regulated by HLH-2: the protocadherin cdh-3, and two genes encoding secreted ext

121 These results demonstrate that the protocadherin Celsr3 gene is essential for both tangenti

122 results are consistent with a model in which protocadherin cis-dimers engage in a head-to-tail intera

123 in diversified ectodomains drives vertebrate protocadherin cluster evolution.

124 ation in copy number and sequence content of protocadherin cluster genes among vertebrate species cou

125 Here we show that protocadherin cluster genes in human, mouse, rat, and ze

126 bclusters, alpha, beta, and gamma, as the 54 protocadherin cluster genes in human.

127 We found that coelacanth has 49 protocadherin cluster genes organized in the same three

128 We have completed an analysis of zebrafish protocadherin cluster genes.

129 protocadherin gamma A (PCDHGA) genes of the protocadherin cluster on chromosome 5q31.

130 em duplications have generated two zebrafish protocadherin clusters comprised of at least 97 genes.

131 Zebrafish have two unlinked protocadherin clusters, DrPcdh1 and DrPcdh2.

132 Like mammalian protocadherin clusters, DrPcdh1 has both alpha and gamma

133 , a synergistic underexpression of the gamma-protocadherin complex, located at Chr5q31 is also shown.

134 delta-Protocadherins comprise a family of neural adhesion mole

135 The protocadherins comprise the largest subgroup within the

136 Protocadherins constitute the largest subfamily of cadhe

137 mu-Protocadherin contains both N and O glycosylations.

138 ed that a proximal to distal gradient of the protocadherin Dachsous (Ds) acts as a cue for planar cel

139 Hippo activity, probably via binding to the protocadherin Dachsous.

140 The protocadherins Dachsous and Fat initiate a signaling pat

141 nt studies in Drosophila melanogaster of the protocadherins Dachsous and Fat suggest that they act as

142 polarity proteins, and another utilizing the protocadherins Dachsous and Fat, and the atypical myosin

143 e of a putative binding partner of Fat4, the protocadherin Dchs1.

144 rprisingly, O-mannosylation of cadherins and protocadherins does not require POMT1 and/or POMT2 in co

145 s showed that each of the investigated delta-protocadherins exhibits a spatially restricted and tempo

146 lved before the divergence of these distinct protocadherin families.

147 Recently, a member of the protocadherin family of cell adhesion molecules, called

148 Although the protocadherin family of cell surface receptors is widely

149 The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP

150 The Drosophila protocadherin Fat (Ft) regulates growth, planar cell pol

151 Signaling via the large protocadherin Fat (Ft), regulated in part by its binding

152 teractions by inhibiting the activity of the protocadherin Fat (Ft).

153 Here, we report that the protocadherin Fat acts as an upstream component in the H

154 we have examined the functions of the giant protocadherin FAT by generating a transgenic mouse lacki

155 recent studies taken together show that the protocadherin Fat can regulate Warts in two different wa

156 y (PCP) signaling mediated by the Drosophila protocadherin Fat depends on its ability to change the s

157 The large protocadherin Fat functions to promote Hippo pathway act

158 The protocadherin Fat is known as a tumor suppressor regulat

159 The protocadherins Fat (Ft) and Dachsous (Ds) are required f

160 he spatial distribution of bonds between the protocadherins Fat (Ft) and Dachsous (Ds), which form he

161 show that signaling interactions between the protocadherins Fat and Dachsous, organized by the morpho

162 The protocadherin Fat4 influences signaling from stromal to

163 The protocadherins Fat4 and Dchs1 act as a receptor-ligand p

164 The seven-transmembrane protocadherin, Flamingo, functions in a number of proces

165 the first evidence for the requirement of a protocadherin for normal function of the mammalian inner

166 ed one of these genes, a member of the gamma-protocadherins for further study to determine the basis

167 In the enterocyte brush border, protocadherin function requires a complex of cytoplasmic

168 whether oligomerization also plays a role in protocadherin function.

169 , but little is known about the mechanism of protocadherin function.

170 pecies could reflect adaptive differences in protocadherin function.

171 Little is known about how protocadherins function in cell adhesion and tissue deve

172 cadherins in the mouse, i.e., the clustered protocadherins, functions in an analogous fashion to pro

173 We screened for variation in the 12 protocadherin gamma A (PCDHGA) genes of the protocadheri

174 enes, (Ring1 and YY1 binding protein (RYBP); protocadherin gamma subfamily C,3 (PCDHGC3); and signal

175 The 22 gamma-Protocadherin (gamma-Pcdh) adhesion molecules encoded by

176 The gamma-protocadherins (gamma-Pcdhs) are a family of 22 adhesion

177 The 22 gamma-protocadherins (gamma-Pcdhs) potentially specify thousan

178 Here we show that the gamma-protocadherins (gamma-Pcdhs), a family of 22 neuronal ad

179 ion molecule family encoded by the 22-member protocadherin-gamma (Pcdh-gamma) gene cluster in its con

180 Twenty-two tandemly arranged protocadherin-gamma (Pcdh-gamma) genes encode transmembr

181 e C-terminal TM and intracellular domains of protocadherin-gamma, a cell surface glycoprotein.

182 gamma2-GABA(A)R) specifically interacts with protocadherin-gammaC5 (Pcdh-gammaC5) in the rat brain.

183 aptic cell adhesion molecules encoded by the protocadherin gene cluster are hypothesized to provide a

184 e by complete sequencing and analysis of the protocadherin gene cluster of the Indonesian coelacanth,

185 he encoded ectodomains of each member of the protocadherin gene clusters are present in one large exo

186 Protocadherin gene clusters on chromosome 5q31 may act a

187 rthologous human (750 kb) and mouse (900 kb) protocadherin gene clusters.

188 Because a precise pattern of protocadherin gene expression is required for neuronal d

189 t we examined in greater detail involved the protocadherin gene family clusters on chromosome 5 (PCDH

190 It is an unusual member of the protocadherin gene family containing two large overlappi

191 populations, suggesting that a reduction in protocadherin gene number is not obviously deleterious.

192 se chromosome 10 contains Pcdh15, encoding a protocadherin gene that is mutated in ames waltzer and c

193 gamma and PCDH-alpha suggests that dozens of protocadherins generated by Pcdh-alpha and Pcdh-gamma ge

194 he combinatorial expression of the clustered protocadherin genes (Pcdhalpha, -beta, and -gamma).

195 mic organization of several additional human protocadherin genes by using DNA sequence information in

196 We sequenced the promoters of all 13 alpha protocadherin genes in 96 European Americans and identif

197 Remarkably, all of these protocadherin genes share a common feature: most of the

198 ge ectodomain exons are a general feature of protocadherin genes we have investigated the genomic org

199 rin 23, but differs significantly from other protocadherin genes, such as Pcdhalpha, beta, or gamma.

200 y large exons is a characteristic feature of protocadherin genes.

201 tion of cyclic AMP signaling, cell death and protocadherin genes.

202 creased in expression and included clustered protocadherin genes.

203 Protocadherins have been implicated in synapse developme

204 Protocadherins have been shown to regulate cell adhesion

205 Among genes implicated by the top DMRs were protocadherins, homeobox genes, MAPKs and ryanodine rece

206 PCNS (Protocadherin in Neural crest and Somites), a novel Pcdh

207 ly that adhesive interactions mediated by mu-protocadherin induce signaling events that regulate bran

208 The cytoplasmic domains of microvillar protocadherins interact with the scaffolding protein, ha

209 n adhesive function by local expression of a protocadherin is a novel mechanism for controlling cell

210 mu-Protocadherin is expressed in two forms that are develop

211 Expression of these two protocadherins is similar in the ventromedial telencepha

212 res for the EC1-EC3 domain regions from four protocadherin isoforms representing the alpha, beta, and

213 that encompasses >70 genes at the clustered protocadherin locus (hereafter referred to as cPcdh).

214 The subclass currently consists of 18 protocadherin members.

215 ndrome lacking harmonin exhibits microvillar protocadherin mislocalization and severe defects in brus

216 d in the interneuron module, as well as in a protocadherin module.

217 tion factor Cdx2 activates expression of the protocadherin Mucdhl, which interacts with beta-catenin

218 e transcription of the gene that encodes the protocadherin Mucdhl.

219 Here, we demonstrate the requirement for NF-protocadherin (NFPC) and its cytosolic partner TAF1/Set

220 The homophilic cell adhesion molecule NF-protocadherin (NFPC) is expressed in the mid-dorsal opti

221 We examined the function of NF-protocadherin (NFPC), a novel cell adhesion molecule ess

222 functionally interacts with Ror2 to regulate protocadherin papc expression and morphogenesis.

223 65% amino acid identity to Xenopus paraxial protocadherin (PAPC) and 42-49% amino acid identity to P

224 Paraxial protocadherin (PAPC) controls cell sorting and morphogen

225 Paraxial protocadherin (PAPC) expression is lost in the nascent m

226 Paraxial protocadherin (PAPC) is an adhesion protein with six cad

227 We previously showed that Xenopus paraxial protocadherin (PAPC) mediates cell sorting and morphogen

228 g, and demonstrated that it enables paraxial protocadherin (PAPC) to promote tissue separation throug

229 llowed by the transmembrane protein paraxial protocadherin (PAPC).

230 iated by Wnt signaling, Snail1, and paraxial protocadherin (PAPC).

231 Here, we focused on the role of paraxial protocadherin (PAPC/Pcdh8) in this process.

232 odulating complexes (AMCs) with the paraxial protocadherin (PAPC; denoted as AMCP) and C-cadherin (de

233 pus and zebrafish have demonstrated that the protocadherin, papc, is expressed in an anterior-specifi

234 Here we show that the expression of delta-protocadherins partitions the zebrafish optic tectum int

235 LNCaP cells directly transformed with protocadherin-PC cDNA were comparatively resistant to ph

236 king a signal sequence and we refer to it as protocadherin-PC.

237 The mouse protocadherin (Pcdh) -alpha, -beta, and -gamma gene clus

238 The mammalian Protocadherin (Pcdh) alpha, beta, and gamma gene cluster

239 hromatin looping in mammalian genomes, using protocadherin (Pcdh) and beta-globin as model genes.

240 The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded b

241 nd that Celsr3, a member of the nonclustered protocadherin (Pcdh) family, is predominantly expressed

242 The genomic architecture of protocadherin (Pcdh) gene clusters is remarkably similar

243 The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single gen

244 Fifty-eight cadherin-related protocadherin (Pcdh) genes are tandemly arrayed in three

245 This region encompasses 53 individual protocadherin (PCDH) genes divided among three gene clus

246 f) binding sites, for example, the clustered protocadherin (Pcdh) genes, where we show Smchd1 and Ctc

247 The murine genome contains approximately 70 protocadherin (Pcdh) genes.

248 recently demonstrated that initiation of cdh/protocadherin (pcdh) O-Man glycosylation is not dependen

249 A large number of neural transmembrane protocadherin (Pcdh) proteins is encoded by three closel

250 A large family of neural protocadherin (Pcdh) proteins is encoded by three closel

251 stinct repertoires of alpha, beta, and gamma protocadherin (Pcdh) proteins, which function in neural

252 ingle nucleotide polymorphisms (SNPs) in the protocadherin (PCDH)-alpha, -beta and -gamma gene cluste

253 The clustered protocadherins (Pcdh) are encoded by three closely linke

254 Genetic studies demonstrate that gamma-protocadherins (PCDH-gamma) are required for the surviva

255 gamma-Protocadherins (PCDH-gamma) regulate neuronal survival i

256 gamma-Protocadherins (Pcdh-gammas) are involved in cell-cell i

257 It has been proposed that gamma-protocadherins (Pcdh-gammas) are involved in the establi

258 ic approach to investigate the role of gamma-protocadherins (Pcdh-gammas) in hypothalamic neuronal ci

259 h4, Cdh6, Cdh7, Cdh8, Cdh11) and eight delta-protocadherins (Pcdh1, Pcdh7, Pcdh8, Pcdh9, Pcdh10, Pcdh

260 on, we placed the human homolog of the mouse protocadherin Pcdh15 in the linkage interval defined by

261 d99C, the Drosophila ortholog of human Usher protocadherin PCDH15, is expressed in several embryonic

262 and cell type specific expression of a novel protocadherin, PCDH20, in the olfactory system.

263 es are free to make junctions containing the protocadherin, PCDH21, with the inner segment plasma mem

264 tosis-selective cell surface localization of protocadherin PCDH7, a member of a family with anti-adhe

265 turn activates multiple genes including the protocadherin pcdh8l (PCNS).

266 The alpha-, beta-, and gamma-protocadherins (Pcdhalpha, Pcdhbeta, and Pcdhgamma) comp

267 Cs, both processes are mediated by the gamma-protocadherins (Pcdhgs), a family of 22 recognition mole

268 Clustered protocadherins (Pcdhs) are a family of cadherin-like mol

269 The clustered protocadherins (Pcdhs) are a large family of cadherin-li

270 Clustered protocadherins (Pcdhs) are arranged in gene clusters (al

271 Protocadherins (Pcdhs) are cell adhesion and signaling p

272 The clustered protocadherins (Pcdhs) comprise >50 putative synaptic re

273 Here we demonstrate roles for the clustered protocadherins (Pcdhs) in dendritic self-avoidance and s

274 Clustered protocadherins (Pcdhs) mediate numerous neural patternin

275 ession of alpha-, beta-, and gamma-clustered protocadherins (Pcdhs) provides vertebrate neurons with

276 Protocadherins (Pcdhs), a major subfamily of cadherins,

277 sively, much less is known about the related protocadherins (Pcdhs), which together make up the major

278 , Drosophila Dscams and vertebrate clustered protocadherins (Pcdhs).

279 A consensus protocadherin promoter motif sequence identified in mamm

280 racellular and transmembrane domains of each protocadherin protein are encoded by an unusually large

281 hastic single-neuron expression of clustered protocadherin protein isoforms.

282 Clustered protocadherin proteins (alpha-, beta-, and gamma-Pcdhs)

283 are apparent between zebrafish and mammalian protocadherin proteins.

284 We thus term this protein mu-protocadherin, reflecting the hybrid nature of its extra

285 ely 120 diverse membrane proteins, including protocadherins, ROBOs, netrin receptors, neuroligins, GP

286 nt to both non-clustered delta and clustered protocadherin subfamilies.

287 homology between the cytoplasmic domains of protocadherin subfamily members.

288 study, we cloned eight members of the delta-protocadherin subfamily of cadherins (Pcdh1, Pcdh7, Pcdh

289 these genes was found to be a member of the protocadherin subfamily, based on amino acid sequence co

290 spatiotemporal expression patterns of delta-protocadherins suggest that they have multiple and diver

291 izing gene conversion events than coelacanth protocadherins, suggesting that recombination- and dupli

292 B interacts with USH1C and MYO7B, which link protocadherins to the actin cytoskeleton.

293 functions of O-Man glycans on cadherins and protocadherins, we used a combinatorial gene-editing str

294 Genes encoding stochastically expressed protocadherins were transcribed by increased numbers of

295 composed of protocadherin-24 and mucin-like protocadherin, which target to microvillar tips and inte

296 adherin-18a (Pcdh18a) belongs to the delta 2-protocadherins, which constitute the largest subgroup wi

297 to be uniquely enlarged in vertebrates: the protocadherins, which regulate neuronal development, and

298 Colocalization of mu-protocadherin with beta-catenin was noted primarily at t

299 We propose a model in which association of a protocadherin with Ncad acts as a switch, converting bet

300 The gene pair protocadherin X and Y within this region is under new se