ライフサイエンスコーパス: proton

1 Al atoms, similar to the Bronsted acid site proton.

2 agnetic interaction between target and water protons.

3 Cs) are neuronal receptors for extracellular protons.

4 proposed for the BR cytoplasmic channel for protons.

5 longitudinal range straggling for energetic protons.

6 nt that the carboxyl group acquires a second proton (1H(+)).

7 1,5-dicyclohexylimidazole), toward different proton (4-nitrophenol and [DMF.H(+)](CF3SO3(-))) (DMF =

8 It was found that with 2 MeV protons, a fluence of 10(16) protons/cm(2) was necessary

9 nalized by evaluation of energy barriers for proton abstraction required to form the intermediate und

10 ore commonly observed electron-sheath driven proton acceleration.

11 e Science Experimental Facility of the Japan Proton Accelerator Complex (J-PARC) for an iron sample.

12 ys the energy from quinone reduction to pump protons across its complete approximately 200-A membrane

13 Acid-sensing ion channels (ASICs) are proton-activated Na(+) channels expressed in the nervous

14 Proton adsorption on metallic catalysts is a prerequisit

15 rge neutrality over a wide pH range, and low proton affinity which results in low electrospray interf

16 er and uses the released free energy to pump protons against the transmembrane proton gradient.

17 tive to dilute metabolites with exchangeable protons, allowing tissue characterization in diseases su

18 The diffusion of protons along biological surfaces and the interaction of

19 ch are neutral macrocycles without ionizable protons, also showed interesting coordination chemistry.

20 eloped for heterolytic cleavage of H2 into a proton and a hydride, akin to frustrated Lewis pairs.

21 the data suggest that the separation of the proton and electron to different reagents does not signi

22 Interestingly, the addition of the second proton and nucleophile occurs in a 1,4-fashion, again wi

23 e recognition profile of SbMATE, showing the proton and/or sodium-driven transport of (14C)-citrate a

24 channels that are activated by extracellular protons and are involved in a wide range of physiologica

25 y resolution (deltaE/E) of CR-39 for few MeV protons and Carbon ion is found to be about 3%.

26 Charged particles such as protons and carbon ions are an increasingly important to

27 Model results agreed closely for protons and carbon-ions (mean error within approximately

28 inner-membrane complex that does not conduct protons and does not bind to PG until it is inserted int

29 The spectral flux of space electrons, protons and ions for example in the radiation belts is i

30 The internal structure of nucleons (protons and neutrons) remains one of the greatest outsta

31 e interface and competitive sorption between protons and other cations for binding sites on the surfa

32 to study the relative transport kinetics of protons and reactants to an electrocatalyst and the rela

33 We show that proton application causes a global compaction of the ext

34 Both lithium ions and protons are found to be involved in the oxygen reduction

35 In this way, mobile phase protons are prevented from interfering with the process

36 Paracoccus denitrificans, we show that four protons are pumped for every two electrons transferred i

37 reactive aldehyde group that either transfer protons at the transition state or trap the initially fo

38 porous Teflon membrane used as an additional proton barrier and light scattering layer.

39 The number of proton beam and heavy ion therapy facilities is increasi

40 nt target geometries are presented and their proton beam deliverance characterized: cylindrical (slas

41 The characteristics of laser driven proton beams can be efficiently controlled and optimised

42 ration mechanism, namely quasi-monoenergetic proton beams with small divergence in addition to the mo

43 We show that proton binding at the intracellular pH sensor perturbs t

44 e describe a switching mechanism that senses proton binding by marked reorganization of subunit inter

45 ters via Grotthuss shuttling and reveal that proton binding to the extracellular side of the transpor

46 ctivation because of strong cooperativity in proton binding.

47 Conserved proton-binding residues in all the membrane components w

48 sed the intriguing question of whether acid (protons) can evoke itch like other algogens by spatial c

49 urate determination of experimental one-bond proton-carbon coupling constants ((1)JCH) in small molec

50 The influenza M2 protein not only forms a proton channel but also mediates membrane scission in a

51 The opening of the proton channel involves association of the plug helices

52 e M2 protein, a homotetrameric transmembrane proton channel that acidifies the virion after endocytos

53 the HIV-1 gp41 fusion protein, the influenza proton channel, and the MCU pore.

54 established inhibitors of the influenza A M2 proton channel, the mechanisms by which they are rendere

55 previously unreported HVCN1, a voltage-gated proton channel-encoding gene and B-cell receptor signali

56 us thermophilus The simulations suggest that proton channels are established at symmetry-related loca

57 by mutations in the gene encoding endosomal proton-chloride exchange transporter 5.

58 that with 2 MeV protons, a fluence of 10(16) protons/cm(2) was necessary to induce a significant char

59 (D405N) mutant was partially inhibited by a proton concentration of 10(-5.5) m, but 10(-9.0) m produ

60 annels and the ICl was nearly insensitive to proton concentrations between 10(-5.5) and 10(-9.0) m.

61 er normal, includes the W41 primary gate for proton conductance and may prevent the gate from opening

62 alternative view for how these drugs prevent proton conductance.

63 y vary the unit cell dimensions and tune the proton conducting pathways.

64 (-1) at 25 degrees C and 40% RH, a very high proton conduction value for low humidity and moderate te

65 ce analysis of pelletized powders revealed a proton conduction value of over 10(-3) S cm(-1) at 25 de

66 e that this inter-helical motion accompanies proton conduction.

67 The proton conductivities for the La and Pr complexes were r

68 An unprecedented combination of high proton conductivity (326 mS cm(-1) at 80 degrees C) and

69 n increases fuel cell performance due to the proton conductivity and macroporosity characteristics of

70 he DNA-threaded ZIF-8 membrane exhibits high proton conductivity of 3.40 x 10(-4) S cm(-1) at 25 degr

71 Proton conductivity of the polymer electrolyte membranes

72 ic modulus (dry condition), 160% increase in proton conductivity, 300% increase in water uptake, cycl

73 al cofactor, the complex is shown to mediate proton coupled electron transfer (PCET) at the {SN} liga

74 kinetic isotope effect (kH/kD = 20) suggests proton coupled electron transfer in the initial oxidatio

75 A cobalt-catalyzed proton-coupled electron transfer (PCET) mediated regiose

76 Proton-coupled electron transfer (PCET) reactions at a p

77 RT is facilitated by sequential proton-coupled electron transfer (PCET) steps along a pa

78 power of nonadiabatic quantum treatments of proton-coupled electron transfer in SLO and (ii) sensiti

79 tro occurs only at alkaline pH, suggesting a proton-coupled electron transfer precedes formation of t

80 s, dynamics, and molecular mechanism for the proton-coupled electron transfer process linked to the Q

81 reagents does not significantly inhibit the proton-coupled electron transfer process.

82 These proton-coupled electron transfer reactions occur without

83 the catalytic cycle, allowing intramolecular proton-coupled electron transfer to lower the potentials

84 a conserved tyrosine residue that reacts via proton-coupled electron transfer with the iron(III)-supe

85 sequential abstraction of a hydrogen atom or proton-coupled electron transfer.

86 s both mTOR Complex 1 and 2 and requires the proton-coupled folate transporter (PCFT, SLC46A1).

87 ate that promotes substrate coordination via proton-coupled ligand exchange.

88 First-principles calculations of proton-coupled redox potentials and magnetizations revea

89 the pyrrole NH also plays a key role in the proton-coupled, two-electron oxidation of isophlorin to

90 ong with measurements that vary the electron/proton delivery rate and use different substrates, revea

91 efficient (ADC) maps with fat-saturated (FS) proton density (PD)-weighted turbo spin-echo (TSE) imagi

92 graphy, magnetic resonance imaging-estimated proton density fat fraction, quantitative collagen conte

93 tiparametric MRI consisting of Dixon MRI and proton-density-weighted ZTE MRI to directly synthesize p

94 alytic proton reduction in CaI proceeds by a proton-dependent process.

95 It is demonstrated that the proton depletion zone may be constrained and controlled

96 Its component ions-hydroxide and protons-diffuse much faster than other ions.

97 n reduction reaction (ORR) was studied under proton diffusion-limited conditions in slightly acidic e

98 All bran samples showed similar proton distributions at a 44% moisture level, although t

99 gh capacitance might be attributed to mobile protons donated by atmospheric water.

100 chiff base through a mutation of the primary proton donor (E108Q).

101 hich apparently hinder the close approach of proton donor and acceptor that facilitates MS-CPET.

102 another aspartic acid residue functions as a proton donor in hydrolysis.

103 Here, we mutagenized the predicted proton donor residues and the nucleophilic catalyst resi

104 rmed the catalytic function of the predicted proton donor residues, and sequence analysis suggested t

105 cene and weak O-H bonds upon activation with proton donors.

106 l energy production involves the movement of protons down a large electrochemical gradient via ATP sy

107 (13)C/(13)C chemical shift correlations via proton driven spin diffusion provided distance constrain

108 typically developing controls underwent 3 T proton echo-planar spectroscopic imaging (PEPSI) MRS sca

109 We found a robust reduction of the proton effect at high [Ca(2+) ]i .

110 se, and substrate accumulation depend on the proton electrochemical gradient (DeltamuH(+)) across the

111 Multiple-site concerted proton-electron transfer (MS-CPET) reactions were studie

112 thermodynamic analyses evidence a concerted proton-electron transfer pathway for these processes.

113 udes solvation and intra- and intermolecular proton-, electron-, and energy transfer events of the gu

114 Around Earth, trapped energetic protons, electrons and other particles circulate at alti

115 ereoselectively via ring opening followed by proton elimination.

116 ng condensed-phase reaction, where catalytic proton exchange between intermediate(s) and solvent (Bro

117 as a three electrode system with Nafion as a proton exchange membrane (PEM).

118 ich is crucial for large-scale deployment of proton exchange membrane fuel cells (PEMFCs).

119 that these, when added as an additive to the proton exchange Nafion membrane, provide significant enh

120 at potential as a new type of cost-efficient proton-exchange membranes (PEM) for electrochemical devi

121 e determined from titration experiments, and proton-exchange rates are measured at pH 5 and pH 7.

122 e BBB, we identify NHE9, an endosomal cation/proton exchanger, as a novel regulator of this system.

123 ne perturbs the chloride-binding site in the proton-exit channel.

124 lly-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as

125 Surprisingly, the proton from the acceptor was absorbed by the precipitate

126 e molecule, accompanied by the uptake of two protons from the cytoplasm.

127 The highly energetic proton generates a time-varying field that is highly loc

128 ry catalysis, powered by the electrochemical proton gradient across the membrane.

129 s the O2 level; (2) decreased cross-membrane proton gradient from membrane damage, coupled with hypox

130 gy to pump protons against the transmembrane proton gradient.

131 Defects of the V-type proton (H(+)) ATPase (V-ATPase) impair acidification and

132 are subject to damage arising from energetic proton (H(+)) irradiation.

133 oned selectivities by delivering/accepting a proton (H(+)) via its N-H bond cleavage/formation.

134 he calculated trajectory of H indicates that proton has a good mobility in MC, oxygen can rotate arou

135 res, which consist of a wide-energy range of protons, heavy ions and secondary radiation produced in

136 Conventional T1-weighted proton (hydrogen 1 [(1)H]) images and perfusion images b

137 M, the interaction of the wave packet with a proton in a protein provides the dynamic information.

138 Substitution of the thiol proton in cysteine with m-carborane furnished 2-amino-3-

139 relaxation time, the T1 relaxation time, of protons in a magnetic field after excitation by a radiof

140 D channel provides the route for all pumped protons in bacterial A-type CcOs, studies of bovine mito

141 information on the properties of individual protons in even the most challenging of energy-convertin

142 xploit (i) the narrow resonance of aliphatic protons in free substrate for selective radio-frequency

143 quilibrium exists in our experiments between protons in the near-membrane layers and in the aqueous b

144 or fast magnetic transfer of this label over protons in the target backbone.

145 ns a lack of systematic studies of energetic proton induced changes in the photoelastic properties of

146 We propose a proton-induced desorption mechanism associated with pKa

147 We further show that like the proton-insensitive ASIC2b and ASIC4, nmrASIC3 forms func

148 nds of environments from acidic to alkaline, proton intercalation.

149 long with two external electrons, reduce two protons into two hydrides, from which reductive eliminat

150 rix, changes the net isotope effect, but the proton inventory plot remains linear, consistent with an

151 re, we present the effects of irradiation by protons, iron, and silver ions at MeV-level energies on

152 For that reason, the effect of proton irradiation on photoelastic coefficients of GaAs

153 y retention, and network stability following proton irradiation were observed at the two-week time po

154 e (20-week) time points following whole body proton irradiation.

155 621 megaelectronvolts (MeV) (the mass of the proton is 938 MeV) also revealed a large binding energy

156 domain of bacteriorhodopsin where an excess proton is shared by a cluster of internal water molecule

157 control insulin secretion via its effect on proton leak but instead via modulation of glucose-fueled

158 and Sib LCLs exhibited significantly higher proton leak respiration.

159 ient metabolism, as shown by the increase in proton leak.

160 rs on the timescale of 100-200 ns before the proton-loading site is protonated.

161 en atom transfer (HAT) and second sequential proton loss electron transfer (SPLET) mechanisms are les

162 e (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy ((1)H-MRS).

163 Proton magnetic resonance spectroscopy at 7T was perform

164 in vivo in patients with schizophrenia using proton magnetic resonance spectroscopy at 7T, which allo

165 Following baseline proton magnetic resonance spectroscopy scans targeting t

166 Protons may be enabled to intercalate between monolayer

167 mmonium group results in the acceleration of proton migration (inverse primary isotope effect), where

168 The activation energies for proton migration are calculated to be 50 and 27 meV for

169 ted on the carbonate ions, implying that the proton migration is a synergetic process and the whole c

170 n can rotate around carbon to facilitate the proton migration, while the movement of carbon is very l

171 All three ligand types enhance proton mobility at the edge site through a unique bioins

172 , the gas-phase reaction follows the "mobile proton model" to form the products via a number of inter

173 UCP1 dissipates the mitochondrial proton motive force (Deltap) generated by the respirator

174 may also be targets because 1 collapsed the proton motive force in membrane vesicles.

175 Its product, the proton-motive force, is composed of an electrical potent

176 ureus by vancomycin, rhamnolipids facilitate proton-motive force-independent tobramycin uptake, and 2

177 18)F-fluoroethyl)-l-tyrosine ((18)F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover me

178 Here, we use side-chain proton NMR relaxation dispersion measurements, X-ray cry

179 ew Zealand and Australia were analysed using proton NMR spectroscopy coupled with chemometrics.

180 High-field and low-field proton NMR spectroscopy were used to analyse lipophilic

181 Proton Nuclear Magnetic Resonance ((1)H NMR) was employe

182 The proton nuclear magnetic resonance analysis indicated tha

183 ned flour was investigated using time-domain proton nuclear magnetic resonance relaxometry, and relat

184 he oxidation products formed were studied by Proton Nuclear Magnetic Resonance.

185 Significantly higher proton numbers in laser-forward direction are observed w

186 = [-3.0, -3.0, 8.7] MHz to the exchangeable proton of a conserved histidine and conclude that the hi

187 The neutral condition allows acidic protons of alcohols, phenols, and malonates to be presen

188 identifying for the first time those of the protons of esters of phytol and of geranylgeraniol.

189 related with the effect of the intercalated protons on electrical conductance and the adsorption ene

190 lopes as steep as -120 mV/pH-suggested a two proton-one electron transfer.

191 o predict the sensitivity of cells to X-ray, proton or carbon ion exposures in vitro against over 800

192 ich uses X-rays, gamma rays, electron beams, protons, or high-intensity focused ultrasound.

193 N139 thus assumes a gating function by which proton passage through the D-channel toward E286 is like

194 quence allowed distinction between different proton pools with different T1 relaxation times, particu

195 cate a common mechanism of regulation of the proton pump and a potassium channel, two essential eleme

196 lar simulations to study the function of the proton pump in complex I from Thermus thermophilus The s

197 : Studies have reported associations between proton pump inhibitor (PPI) use and dementia.

198 g methods, enhancing antibiotic and possibly proton pump inhibitor stewardship, and prescribing proph

199 BACKGROUND & AIMS: Proton pump inhibitors (PPI) have been associated with a

200 Proton pump inhibitors (PPIs) are widely used to treat g

201 Proton pump inhibitors (PPIs) have been known to induce

202 Recent studies suggest that proton pump inhibitors (PPIs) may increase the risk for

203 e the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use

204 per gastrointestinal bleeding; the effect of proton pump inhibitors on ventilator-associated pneumoni

205 ptosomal mitochondria and synaptic vesicular proton pump protein (V-ATPase H) levels.

206 to orient the insertion of the light-driven proton pump proteorhodopsin (PR) into liposomes.

207 Using full-dose proton-pump inhibitor and high-dose Metronidazole in gro

208 dose Metronidazole in group A, and full-dose proton-pump inhibitor and prescription from a Gastroente

209 Consequently, although co-prescription of proton-pump inhibitors (PPIs) reduces upper gastrointest

210 Proton pumping A-type cytochrome c oxidase (CcO) termina

211 86 through the D-channel, which impairs both proton pumping and the chemical reaction.

212 channel that impair, and sometimes decouple, proton pumping from the chemical catalysis.

213 tion step that could thermodynamically drive proton pumping in complex I.

214 onsible for the delivery of electrons to the proton pumping subunit.

215 Renal intercalated cells (ICs) express the proton pumping vacuolar H(+)-ATPase (V-ATPase) and are e

216 let simultaneously measured the light-driven proton-pumping activities of each bio-pixel.

217 embrane protein that synthesizes ATP through proton-pumping activity across the membrane.

218 ATP-hydrolase activity, which is coupled to proton-pumping activity.

219 he D-channel is imperative to achieving high proton-pumping efficiency in the WT CcO.

220 To better understand the proton-pumping mechanism of the wild-type (WT) CcO, much

221 Shifting the action spectra of these proton pumps beyond 700 nm would generate new prospects

222 tributions, and successfully fit to cellular proton radiosensitivity using a single dose-related para

223 [FeFe] hydrogenases catalyze proton reduction and hydrogen oxidation displaying high

224 The injected electrons induce proton reduction at a Pt electrode.

225 on using COF photosensitizers with molecular proton reduction catalysts for the first time.

226 nd that the Hox-->HredH(+) step of catalytic proton reduction in CaI proceeds by a proton-dependent p

227 owed by an electrocatalytic amplification of proton reduction on an inert carbon fiber electrode.

228 tion of redox intermediates during catalytic proton reduction.

229 The proton-reduction catalytic properties of TPSb(OH)2 (TP=5

230 he hydrogen-bonding pattern conducive to the proton relay is not thermodynamically favorable on the g

231 a proton relay mechanism between a ketone-like oxygen and

232 ribution corresponds to deprotonation of the proton release complex (PRC), a complex in the extracell

233 ton uptake complex, a cluster with an excess proton reminiscent to the PRC but located in the cytopla

234 ile acid receptors such as GPR131 (TGR5) and proton-sensing receptors such as GPR65 show similar feat

235 ASIC2b and ASIC4, nmrASIC3 forms functional, proton-sensitive heteromers with other ASIC subunits.

236 hypercapnia, but not by hypoxia, and express proton sensors, TASK-2 and Gpr4.

237 lysine reactivity and facilitates efficient proton shuffling.

238 ent 2,2,2-trifluoroethanol (TFE) acting as a proton shuttle.

239 4, but with a lysine residue as an essential proton shuttle.

240 the FrdA(E245) residue, which contributes to proton shuttling during fumarate reduction, for detailed

241 3) hybridized diboron reagent and water as a proton source, a broad range of alkenes undergo hydrobor

242 significantly, influence the position of the proton that resides between Asp-222 and the pyridinyl ni

243 lings of the unpaired electron to the methyl protons that shorten Tm at T > 70 K in currently used la

244 centers referred to and treated at a single proton therapy facility between 1996 and 2015.

245 on therapy, particularly intensity-modulated proton therapy, is still needed.

246 Further optimization of proton therapy, particularly intensity-modulated proton

247 t can be avoided by transfer of the carboxyl proton to water in the same step.

248 that undergoes excited-state intramolecular proton transfer (ESIPT) in neat CH3CN where photodeamina

249 e sensing to be excited-state intramolecular proton transfer (ESIPT).

250 ction pathways: one involves nearly complete proton transfer (PT) from the phenol to the peroxo ligan

251 hael addition-6pi-electrocyclic ring opening-proton transfer and 6pi electrocyclization, in which a v

252 histidine, allow for studies of the role of proton transfer and tautomeric state in enzymatic mechan

253 evels and mutual interactions among electron/proton transfer components and their associated light-ha

254 including predicting isomerization energies, proton transfer energies, and highest occupied molecular

255 a key factor that regulates the branching of proton transfer events and therefore contributes to the

256 and FTIR spectroscopy, we characterized the proton transfer events in the photocycle of ReaChR and d

257 on of an ion pair created by shock-triggered proton transfer from phenol to PVP.

258 irst step in a catalytic cycle that requires proton transfer from the bulk at the N-side to the BNC.

259 Proton transfer in cytochrome c oxidase from the cellula

260 a)Ind undergoes N(1)-H to N(6) long-distance proton transfer in neutral H2O, resulting in normal (340

261 s than 0.02 A correspondingly shortening the proton transfer pathway.

262 dissociated proton, where we also suggest a proton transfer process between one of the photoacids to

263 e and are able to capture the intramolecular proton transfer process.

264 Proton transfer reaction quadrupole mass spectrometry (P

265 n the past to probe the dynamics of internal proton transfer reactions taking place during the functi

266 echanism of action of the modifiers includes proton transfer reactions through oxonium ion formation.

267 The rate of the water-catalyzed proton transfer shows a prominent H/D kinetic isotope ef

268 re-equilibrium electron transfer followed by proton transfer to a water or small water cluster as the

269 transfer to ferrocenium oxidants coupled to proton transfer to various pyridine bases.

270 involving reprotonation, intramolecular 1,6 proton transfer, and concerted but asynchronous bicycliz

271 s using refined coupled (PCET) and decoupled proton transfer-electron transfer (PT/ET) schemes involv

272 dered amine shifts the rate-limiting step to proton transfer.

273 ves a very low activation energy pathway for proton transfer.

274 Selective excited-state intramolecular proton-transfer (ESIPT) photocycloaddition of 3-hydroxyf

275 h African lamb meat and fat were measured by proton-transfer mass spectrometry (PTR-MS) to evaluate i

276 lude intra- and intermolecular electron- and proton-transfer processes, as well as photochromic react

277 The investigated coupling of electron- and proton-transfer reactions is reminiscent of the operatio

278 eutral H2O, resulting in normal (340 nm) and proton-transfer tautomer (480 nm) emissions with an over

279 he mutation of amino acid residues along the proton translocating D-channel that impair, and sometime

280 Several redox-coupled proton translocation mechanisms have been proposed, but

281 re involved in coupling electron transfer to proton translocation, are unknown.

282 ed by the redox reaction is used to initiate proton translocation.

283 ion, intracellular transport, energy coupled proton transport against the electrochemical gradient, a

284 scale molecular dynamics simulations confirm proton transport occurs through these waters via Grotthu

285 cterize the free-energy profiles of explicit proton transport through several important D-channel mut

286 e contributes to the vectorial efficiency of proton transport.

287 The occurrence of proton tunneling in MAPbI3 hybrid organic inorganic pero

288 y smaller than what is predicted by a static proton tunneling model.

289 decreased, as can be expected from a static proton tunneling model.

290 er molecules along the path of the energetic proton undergo ionization at individual molecular level,

291 econd component of the continuum band to the proton uptake complex, a cluster with an excess proton r

292 trate reduction is invariably accompanied by proton uptake.

293 border due to the differing time scales for proton versus heavy-atom motion.

294 on properties of the photoacid's dissociated proton, where we also suggest a proton transfer process

295 the active sites in MoS2 by the intercalated protons, which might be related with the effect of the i

296 is filled with cosmic-ray particles, mostly protons with kinetic energies greater than hundreds of m

297 er, does not corrode, and allows exchange of protons with the surrounding water at ambient temperatur

298 This emulates in a controlled manner the proton-withdrawing conditions of polycrystalline films,

299 These protons would retain most of the kinetic energy of the n

300 reversible chemical transformation of H2 and protons, yet the reaction mechanism and composition of i