ライフサイエンスコーパス: proton transfer

1 fer), and SET-PT (Single Electron Transfer - Proton Transfer).

2 reversible kinetic responses associated with proton transfer.

3 dered amine shifts the rate-limiting step to proton transfer.

4 ire independent control of both electron and proton transfer.

5 e effected, indicating kinetic inhibition of proton transfer.

6 resulting from water-catalyzed excited-state proton transfer.

7 crossing and the coincidence of hydride and proton transfer.

8 ic intermediate and less sterically hindered proton transfer.

9 conserved in the mutant despite the lack of proton transfer.

10 aspartic acid Asp-396 with cysteine prevents proton transfer.

11 gand systems where binding accompanies a net proton transfer.

12 to the occurrence of diabatic excited-state proton transfer.

13 e achieves complete randomization before the proton transfer.

14 proximal oxygen of the OOH moiety during the proton transfer.

15 lsulfenic acid intermediate can be formed by proton transfer.

16 cinnamic acid and an alkene by a nonspecific proton transfer.

17 o Asp1132 with only a minor effect after the proton transfer.

18 a key role for the Zundel complex in aqueous proton transfer.

19 result from an excited-state intramolecular proton transfer.

20 ng multiple pathways of intra- and interunit proton transfer.

21 center followed by rate-controlling N --> P proton transfer.

22 ves a very low activation energy pathway for proton transfer.

23 termediates that differ by an intramolecular proton transfer.

24 ot present in controls that are incapable of proton transfer.

25 drogen bond and the phosphate anion promotes proton transfer.

26 8-DEA-tC against quenching by excited state proton transfer.

27 argely expressed at the transition state for proton transfer.

28 nding to the initial stage of intermolecular proton transfer.

29 more facile for configurations conducive to proton transfer.

30 -N bond ruptures, hydroxide attachments, and proton transfers.

31 ituent on the Criegee carbon that lowers the proton transfer ability and inhibits the formation of a

32 luorescent protein fibrils are permissive to proton transfer across hydrogen bonds which can lower el

33 energy barriers of 0.61-0.75 eV for aqueous proton transfer across hydroxyl-terminated atomic defect

34 Proton transfer across single-layer graphene proceeds wi

35 ically at 80-120 degrees C) and facilitating proton transfer after each monomer enchainment.

36 gh proton mobility in water as a sequence of proton transfers along a hydrogen-bonded (H-bonded) netw

37 hael addition-6pi-electrocyclic ring opening-proton transfer and 6pi electrocyclization, in which a v

38 drogen bond that would facilitate ultrarapid proton transfer and formation of the ol valence anion.

39 Reactions that involve a combination of proton transfer and heavy-atom bonding changes are norma

40 After additional proton transfer and oxygen transfer steps, benzylic alco

41 he MH and XH bonds in one step, facilitating proton transfer and preparing these bonds for further tr

42 s help with gaining further understanding of proton transfer and ring closure tautomerization process

43 In addition to significant changes in amide proton transfer and semisolid macromolecular magnetizati

44 n of which to Glu produced early Schiff base proton transfer and strongly inhibited channel activity.

45 histidine, allow for studies of the role of proton transfer and tautomeric state in enzymatic mechan

46 ed where the binding process is succeeded by proton transfer and the voltammetric responses depend on

47 The results of photoinduced proton transfer and voltage-driven proton-conductivity m

48 formation, promote mechanistically important proton transfers and stabilize multiple transition state

49 Catalysis proceeds via ligand-centered proton-transfer and electron-transfer events while avoid

50 Different analyte ions (e.g., MH(+) via proton-transfer and M(+.) via charge-transfer) were form

51 merization to trans-3-hydroxy-d-proline (1,1-proton transfer) and dehydration to Delta(1)-pyrroline-2

52 involving reprotonation, intramolecular 1,6 proton transfer, and concerted but asynchronous bicycliz

53 ails of the transition states to hydride and proton transfer, and the role of Tyr196 as proton donor.

54 The extraordinarily slow proton transfer appears to be an outcome of configuratio

55 Amide proton transfer (APT) imaging is a noninvasive molecular

56 nvolvement of the buffer base in either atom-proton transfer (APT) or concerted electron-proton trans

57 The quenching occurs via electron/proton transfer, as evidenced by transient absorption sp

58 mical approach based on biocatalysis-coupled proton transfer at the mu-ITIES array opens a new way to

59 lecular dynamic simulations, we screened the proton transfer barrier for different un-doped and nitro

60 MM reaction path calculations determined the proton transfer barrier to be 1.53 kcal/mol.

61 and thermal noise leads to efficient uphill proton transfer, being a manifestation of stochastic res

62 wo protons before and after a pH-induced two-proton transfer between catalytic aspartic acid residues

63 The reaction involves a direct proton transfer between HMSA and (R1)(R2)NH, and the res

64 sses are significantly enhanced by ultrafast proton transfer between the core-ionized water and neigh

65 Excited-state proton transfers between these components were induced b

66 The cage molecules also promote proton transfer by confining the water molecules while b

67 dinated N-H group is necessary for efficient proton transfer by Grotthuss-type structural diffusion.

68 oton-transfer mechanisms, where the rates of proton transfer can be rate limiting for the overall rea

69 se cinchonium betaines were found to promote proton transfer catalysis with 1000-5000 turnovers per 2

70 energy to drive the subsequent hydride- and proton-transfer chemistry, have so far proven difficult

71 evels and mutual interactions among electron/proton transfer components and their associated light-ha

72 The first proton transfer (DHNA* --> TA*) is ultrafast (< system r

73 Proton-transfer dynamics plays a critical role in many b

74 to a model for two alternative pathways for proton transfer, each involving multiple protons.

75 this photostability involves electron-driven proton transfer (EDPT) in Watson-Crick base pairs.

76 reas the 1,4-dinitrobenzene did not show any proton transfer effect in the experimental conditions em

77 s using refined coupled (PCET) and decoupled proton transfer-electron transfer (PT/ET) schemes involv

78 including predicting isomerization energies, proton transfer energies, and highest occupied molecular

79 th hydrogen atom transfer (HAT) and electron-proton transfer (EPT) mechanisms, respectively.

80 -proton transfer (APT) or concerted electron-proton transfer (EPT) pathways.

81 that undergoes excited-state intramolecular proton transfer (ESIPT) in neat CH3CN where photodeamina

82 es generated by excited-state intramolecular proton transfer (ESIPT) in the readily available photopr

83 ate through the excited-state intramolecular proton transfer (ESIPT) photochemical process.

84 the ability for excited-state intramolecular proton transfer (ESIPT) to occur in the case of 1 and 3,

85 zolines undergo excited-state intramolecular proton transfer (ESIPT), generating aza-o-xylylenes capa

86 e sensing to be excited-state intramolecular proton transfer (ESIPT).

87 Selective excited-state intramolecular proton-transfer (ESIPT) photocycloaddition of 3-hydroxyf

88 are interpreted in terms of an excited-state proton transfer (ESPT) process that deactivates the exci

89 luorescence is quenched due to excited-state proton transfer (ESPT) to solvent.

90 a* approximately 8-9) enabling excited-state proton transfer (ESPT).

91 making of covalent bonds, and excited-state proton transfer (ESPT).

92 undergo a relay type of excited-state triple proton transfer (ESTPT) in a concerted, asynchronous man

93 the collective reaction coordinate along the proton-transfer event.

94 a key factor that regulates the branching of proton transfer events and therefore contributes to the

95 ether with the interplay of the electron and proton transfer events during the aromatic ring reductio

96 and FTIR spectroscopy, we characterized the proton transfer events in the photocycle of ReaChR and d

97 ite-directed mutagenesis to characterize the proton transfer events occurring upon the formation of t

98 A series of H-atom, electron, and proton transfer events with a thiophenol cocatalyst furn

99 oposed catalytic mechanism requires multiple proton-transfer events.

100 were difficult or impossible to detect with proton-transfer FAPA or direct analysis in real-time (DA

101 sotope effects support concerted hydride and proton transfer for both light and heavy LDHs.

102 with basic pK(a) < ca. -6 and to interfacial proton transfer for reactants with higher basic pK(a) >

103 g is consistent with the large change in the proton transfer free energy and the smaller change in th

104 ransfer from the nickel to the porphyrin and proton transfer from a carboxylic acid hanging group or

105 ron transfer event is coupled to an internal proton transfer from a conserved glutamic acid to the pr

106 ransfer via a conserved tryptophan triad and proton transfer from a nearby aspartic acid.

107 Proton transfer from A-1(O2') to G40 is concomitant with

108 mechanism of BACE-1 requires water-mediated proton transfer from aspartyl dyad to the substrate, as

109 ossibly A-1(O2'), which would be followed by proton transfer from G40(N1) to A-1(O2').

110 the existence of a possible pathway by which proton transfer from Lys 73 to Ser 130 can occur.

111 C-O bond cleavage step, with an intermediate proton transfer from nitrogen to oxygen facilitated by a

112 on of an ion pair created by shock-triggered proton transfer from phenol to PVP.

113 nd scission is very low and that synchronous proton transfer from the 2'-hydroxyl to the departing ph

114 irst step in a catalytic cycle that requires proton transfer from the bulk at the N-side to the BNC.

115 tonated reactive intermediate involves early proton transfer from the carboxyl group to water along w

116 splays a distinct minimum which results from proton transfer from the carboxylic to the keto group; t

117 Binding of the noncovalent ligand induces a proton transfer from the catalytic Ser70 to the negative

118 pports the hypothesis that the photo-induced proton transfer from the chromophore occurs through wate

119 rs of 2-4 kcal/mol for both steps; moreover, proton transfer from the exocyclic amine of protonated C

120 al-phosphate dissociation is associated with proton transfer from the intermediate oxazoline ring for

121 transient water networks that could support proton transfer from the N phase toward heme a via neutr

122 ydride or dihydrogen complex, resulting from proton transfer from the pendant amine to the metal hydr

123 ed that the acting repair mechanism involves proton transfer from the protonated His365 to the N3' ni

124 ion step, however, is greatly facilitated by proton transfer from the reacting NH3 to the solvent.

125 ts (tau = 65 ps), followed by intermolecular proton transfer from TsOH (tau approximately 3 ns for th

126 Proton transfer from weakly coordinated H2O2 to the oxo

127 al base does not participate, but rather the proton transfers from A-1(O2') to a nonbridging oxygen d

128 ations, we elucidate the key role of surface proton transfers from co-adsorbed H2O molecules in activ

129 tailed picture of the dynamics of long-range proton transfer in a protein against which calculations

130 we investigated the kinetics of electron and proton transfer in a structural variant of the ba3 oxida

131 ded the first kinetic data for excited state proton transfer in a transition metal compound.

132 probe water molecule catalyzed excited-state proton transfer in aqueous solution.

133 The unique three-step excited-state proton transfer in avGFP allows observations of protein

134 voltage changes associated with electron and proton transfer in cytochrome c oxidase could, in princi

135 Proton transfer in cytochrome c oxidase from the cellula

136 Proton transfer in cytochrome c oxidase from the cellula

137 Li2CO3)8H](+), the mechanism and kinetics of proton transfer in lithium molten carbonate (MC) were in

138 a)Ind undergoes N(1)-H to N(6) long-distance proton transfer in neutral H2O, resulting in normal (340

139 for the first time the fundamental of triple proton transfer in pure water for azaindoles as well as

140 nduced by UV excitation triggers interstrand proton transfer in the alternating miniduplex containing

141 rding synchronous versus asynchronous double-proton transfer in the excited state.

142 pe of the proton transfer step, favoring the proton transfer in the fully phosphorylated enzyme.

143 We describe ultrafast proton transfer in the ground electronic state triggered

144 ts do not provide evidence for an ultrarapid proton transfer in the lowest pi* resonance of AA(-), wh

145 ld not be fit to models for one- or multiple-proton transfers in the transition state.

146 on as both a redox enzyme and a proton pump, proton transfer into the protein toward the BNC or towar

147 uces Tyr-O radicals by combined electron and proton transfer involving the phenol and carboxyl groups

148 gating is tightly coupled to intramolecular proton transfers involving the same residues that define

149 olation were subjected both to oxidation and proton transfer ion/ion chemistry to illustrate the iden

150 acid support a transition state in which the proton transfer is complete.

151 Proton transfer is critical in many important biochemica

152 sruption of distance-dependent excited-state proton transfer is important for the successful generati

153 nges are normally categorized by whether the proton transfer is occurring during the rate-limiting st

154 of the thermochemistry and insight into how proton transfer is regulated in this system.

155 Moreover, the intrinsic proton transfer is required for stabilization of the sig

156 stem response of 150 fs), whereas the second proton transfer is reversible, for which the rates of fo

157 rough iron-sulfur clusters, the mechanism of proton transfer is still debated.

158 It is confirmed that proton transfer is the central event in the spectrochemi

159 The two-proton transfer is triggered by electrostatic effects ar

160 n sequential or concerted electron-transfer, proton-transfer is not well understood.

161 does not prove, that electron transfer, not proton transfer, is rate-limiting for these reactions.

162 r completes in less than 4 ps, it triggers a proton transfer lasting over hundreds of microseconds.

163 Amide proton transfer magnetic resonance imaging, a chemical e

164 h African lamb meat and fat were measured by proton-transfer mass spectrometry (PTR-MS) to evaluate i

165 tion of the supramolecular systems, and when proton transfer may occur which, in turn, may affect the

166 However, fundamental issues of proton transfer mechanism via 2D membranes are unclear a

167 three mutants yielding novel information on proton transfer mechanism, rates, isotope effects, H-bon

168 y of enzymes utilize acid-base catalysis and proton-transfer mechanisms, where the rates of proton tr

169 H2Q serves as an electron-proton transfer mediator (EPTM) that enables electrochem

170 onsisting of the proposed conjugate addition-proton transfer-NHC release fundamental steps.

171 dol reaction followed by fast intramolecular proton transfer occurs to give the ring-opened aldehyde.

172 The importance of proton transfer on the intrinsic fluorescence observed i

173 different photochemical reactions, including proton transfer or hydride transfer.

174 th a photoactivation mechanism that involves proton transfer or proton-coupled electron transfer from

175 inst initial outer-sphere electron transfer, proton transfer, or substrate coordination.

176 nction as both redox enzyme and proton pump, proton transfer out of either of the channels toward the

177 s than 0.02 A correspondingly shortening the proton transfer pathway.

178 within the protein structure that gates the proton transfer pathway.

179 with the lattice water to form an efficient proton transfer pathway.

180 ow for this to provide the means to create a proton transfer pathway.

181 Three possible proton transfer pathways (D, K, and H channels) have bee

182 The regulation of competitive proton transfer pathways has been established to be esse

183 structure of MauG it was possible to propose proton-transfer pathways consistent with the experimenta

184 al ion, and by coupling electron transfer to proton transfer (PCET).

185 ic attack to NO by the alcohol, coupled to a proton transfer (PCNA: proton-coupled nucleophilic attac

186 pectroscopy to record, in D2 O, the complete proton transfer photocycle of avGFP, and two mutants (T2

187 Contributions from hydrogen bonding, proton transfer, pi-pi interactions, chromophore twistin

188 ns, in which electron transfer is coupled to proton transfer, play an important role in these process

189 o the N-heterocyclic carbene (NHC)-catalyzed proton-transfer polymerization (HTP) that converts commo

190 t bridge with the Asp252, thus making direct proton transfer possible.

191 dissociated proton, where we also suggest a proton transfer process between one of the photoacids to

192 chanistic viewpoint, a two-step coordination/proton transfer process for N-H activation is shown to b

193 ously described CL/K pathway, fine-tunes the proton transfer process.

194 e and are able to capture the intramolecular proton transfer process.

195 For the proton-transfer process, PPI(+)(PrOH) + H3O(+) --> PPII(

196 results in a complex cascade of photoinduced proton transfer processes and can be interpreted by the

197 gen bonding reactions, and the second one to proton transfer processes.

198 Visualizing proton-transfer processes at the nanoscale is essential

199 g photoswitch in water and enable controlled proton-transfer processes for diverse applications.

200 ype of photoacid is promising for control of proton-transfer processes in physiological conditions an

201 lude intra- and intermolecular electron- and proton-transfer processes, as well as photochromic react

202 emission resulting from the first and second proton-transfer products, denoted by TA* and TB*, respec

203 )Trp), which exhibits unique water-catalyzed proton-transfer properties, AnsA and AnsB are shown to h

204 onally, we have investigated the dynamics of proton transfer (PT) by a variety of methods including d

205 ction pathways: one involves nearly complete proton transfer (PT) from the phenol to the peroxo ligan

206 Here, photoinduced interstrand proton transfer (PT) triggered by intrastrand electron t

207 he 1,3-dinitrobenzene isomer showed a higher proton transfer rate constant ( approximately 25 M(-1) s

208 be built into a highly efficient PEM with a proton transfer rate of seven orders of magnitude higher

209 ion and sluggish proton flux produces O2(-), proton transfer rates commensurate with O-O bond breakin

210 ged peptides/proteins and their fragments by proton transfer reaction (PTR).

211 Proton Transfer Reaction - Mass Spectrometry (PTR-MS) is

212 , proton-relay type of intramolecular double-proton transfer reaction in the excited state, which sho

213 LDH, the concerted mechanism of the hydride-proton transfer reaction is not altered.

214 Caldecott Tunnel near San Francisco, using a proton transfer reaction mass spectrometer (PTR-MS).

215 y of the emerging non-destructive technique, proton transfer reaction mass spectrometry (PTR-MS), was

216 progress in analytical technologies, such as proton transfer reaction mass spectrometry (PTR-MS).

217 Proton transfer reaction mass spectrometry is a useful t

218 Proton transfer reaction quadrupole mass spectrometry (P

219 mass-normalized fluxes were estimated with a Proton Transfer Reaction Time-of-Flight Mass Spectromete

220 anal and flavonoids content, while the novel proton transfer reaction time-of-flight mass spectromete

221 ft turbine engines were investigated using a proton transfer reaction time-of-flight mass spectromete

222 different apple cultivars was studied using proton transfer reaction time-of-flight mass spectrometr

223 se VOC masses were tentatively identified by Proton Transfer Reaction Time-of-Flight Mass Spectrometr

224 ncentrations in good agreement with benchtop proton transfer reaction time-of-flight mass spectrometr

225 eveloped and characterized the novel PTR3, a proton transfer reaction-time-of-flight mass spectromete

226 IF) in the reaction region (drift tube) of a proton transfer reaction-time-of-flight-mass spectromete

227 velength aethalometer and a high-sensitivity proton-transfer reaction mass spectrometer installed at

228 bilization with spin traps and analysis with proton-transfer reaction mass spectrometry.

229 A proton-transfer-reaction mass spectrometer measured time

230 ly controlled experimental setup involving a proton-transfer-reaction time-of-flight mass spectromete

231 emissions in a university classroom using a proton-transfer-reaction time-of-flight mass spectromete

232 sis of Aerosol Online") particle inlet and a proton-transfer-reaction time-of-flight mass spectromete

233 We report the implementation of proton transfer reactions (PTR) and ion parking on an Or

234 In all ChRs investigated so far, proton transfer reactions and hydrogen bond changes are

235 Proton transfer reactions are ubiquitous in enzymes and

236 uperb probe to obtain structural details for proton transfer reactions in biological systems at a tru

237 Because proton transfer reactions play a key role in channel gat

238 ve site water structure that can mediate the proton transfer reactions required for both CmpI formati

239 n the past to probe the dynamics of internal proton transfer reactions taking place during the functi

240 echanism of action of the modifiers includes proton transfer reactions through oxonium ion formation.

241 Competition between hydrogen bonding and proton transfer reactions was studied for systems compos

242 romophore isomerization, structural changes, proton transfer reactions, and water rearrangement on ti

243 ster than channel off-gating and most of the proton transfer reactions, implying that the 13-cis phot

244 in fundamental understanding of the multiple proton transfer reactions.

245 Here, we use cation-to-anion proton-transfer reactions (CAPTR) to reduce the charge s

246 ydrogenase were probed using cation-to-anion proton-transfer reactions (CAPTR), ion mobility, mass sp

247 Proton-transfer reactions (PTR) in the gas phase offer t

248 The investigated coupling of electron- and proton-transfer reactions is reminiscent of the operatio

249 ity of an extensive series of intramolecular proton-transfer reactions postulated to occur during ter

250 gests that water exchange will influence the proton-transfer reactions underlying the acid/base react

251 High abundance of proton-transfer reagent ions was observed with relativel

252 Absence of proton transfer results in formation of an ion-zwitterio

253 to cycles of high and low pH, and show that protons transfer reversibly from the aqueous phase throu

254 e (FMN) dependent, implicating an additional proton transfer role for FMN in turnover of NO.

255 methides (QMs) that underwent either reverse proton transfer (RPT) or electrocyclic ring closure to g

256 g ESPT to aromatic carbon atoms: (1) reverse proton transfer (RPT) to regenerate starting material; (

257 d that further react by an electron transfer-proton transfer sequence forming benzaldehyde derivative

258 sfer (SPLET), and single electron transfer - proton transfer (SET-PT) mechanisms of 5CQA in benzene,

259 The rate of the water-catalyzed proton transfer shows a prominent H/D kinetic isotope ef

260 Also, a proton transfers spontaneously to Asn, advancing a new h

261 The third electron/proton transfer step is the bottleneck for water product

262 miacetal intermediates for the rate-limiting proton transfer step were also intercepted and character

263 changes to the free energy landscape of the proton transfer step, favoring the proton transfer in th

264 This catalysis also involves a separate proton transfer step, mediated by an ordered solvent net

265 termediate 2 unstable against a preferential proton-transfer step at 25 degrees C leading to the gene

266 band and call for a reevaluation of the last proton transfer steps in bacteriorhodopsin.

267 All proton transfer steps involved in proton diffusion throu

268 ay for H2 evolution involves two consecutive proton transfer steps to the H-cluster following transfe

269 ts occurs through a sequence of electron and proton transfer steps, the resulting photoproduct decays

270 Excited state proton transfer studies of six Ru polypyridyl compounds

271 Similar excited-state double-proton transfer takes place for DHNA in a single crystal

272 eutral H2O, resulting in normal (340 nm) and proton-transfer tautomer (480 nm) emissions with an over

273 termediate state between photoexcitation and proton transfer that lives for 3 ps.

274 st redox state in its catalytic cycle, where proton transfer through the K-channel, from K362 to Y288

275 re-equilibrium electron transfer followed by proton transfer to a water or small water cluster as the

276 to a proximal radical cation in concert with proton transfer to a weak Bronsted base.

277 he protein dynamics of the enzyme before the proton transfer to Asp1132 with only a minor effect afte

278 rence ( approximately 36 kcal/mol), favoring proton transfer to formate, is offset by the gain in int

279 ium/aryl carbanion) undergoes intramolecular proton transfer to generate a more stable S-aryl sulfur

280 hich thermodynamically disfavors a concerted proton transfer to H2O.

281 imaging technique, from charge transfer and proton transfer to nucleophilic substitution and elimina

282 cal importance of the dynamics that may link proton transfer to ring compliance.

283 An X-ray crystal structure suggests that proton transfer to the (tBu) PCP (kappa(3)-2,6-((t)Bu2PC

284 formation with subsequent methyl cation and proton transfer to the acid to yield [PC - CH3](-) anion

285 tonated E286, which would in principle allow proton transfer to the BNC, but no proton pumping until

286 embles the cleavage product in the degree of proton transfer to the leaving group.

287 er hand, undergo charge inversion via double proton transfer to the two carboxylate moieties in doubl

288 transfer to ferrocenium oxidants coupled to proton transfer to various pyridine bases.

289 Au-COOH decomposition involves proton transfer to water and was suggested to be rate de

290 n acidic solutions reveals the importance of proton transfers to both carbon and oxygen in the overal

291 s chemical barrier involves both hydride and proton transfers to pyruvate to form l-lactate, using re

292 ollowed by a rate controlling amine assisted proton transfer toward the singly substituted product.

293 his transition state, the new O-H bond after proton transfer undergoes several vibrations before heav

294 peptide cations experience both electron and proton transfers upon photoexcitation, proving an amenab

295 evealed that stepwise C-C bond formation and proton transfer via a chair-shaped transition state dict

296 Excited state charge transfer followed by proton transfer was also observed in the Z form during t

297 ard (TA* --> TB*) and backward (TA* <-- TB*) proton transfer were determined to be (1.7 ps)(-1) and (

298 rmodynamic parameters governing electron and proton transfer were used to determine the appropriate r

299 s O-O bond formation via intramolecular atom-proton transfer with a calculated barrier of only 9.1 kc

300 Direct proton transfer yielding a charge-reduced peptide is als