ライフサイエンスコーパス: protoporphyrin IX

1 or heme oxygenase-1 inhibitors (1400W or tin protoporphyrin IX).

2 hares a biosynthetic pathway with haem up to protoporphyrin IX.

3 the carbon bearing the peroxyl group and the protoporphyrin IX.

4 tizers verteporfin, temoporfin, S3AlOHPc, or protoporphyrin IX.

5 re blocked by the HO-1 inhibitors Zn- and Sn-protoporphyrin IX.

6 due near the propionate carboxyl function of protoporphyrin IX.

7 osynthesis by insertion of ferrous iron into protoporphyrin IX.

8 rmediates from 5-aminolevulinic acid through protoporphyrin IX.

9 hetic pathway by inserting ferrous iron into protoporphyrin IX.

10 y ferrochelatase inserting ferrous iron into protoporphyrin IX.

11 is the enzyme feedback inhibited by hemin or protoporphyrin IX.

12 latase-catalyzed insertion of magnesium into protoporphyrin IX.

13 tic pathway, catalyzes Fe(2+) chelation into protoporphyrin IX.

14 catalyzes the insertion of a Mg(2+) ion into protoporphyrin IX.

15 results in elevated intracellular levels of protoporphyrin IX.

16 roxypropyl)-5-(1-methylbutyl)barbituric acid)protoporphyrin IX.

17 is is the insertion of iron into the ring of protoporphyrin IX.

18 ectron oxidation of protoporphyrinogen IX to protoporphyrin IX.

19 by both hemin (ferric protoporphyrin IX) and protoporphyrin IX.

20 atalyzes the insertion of an Mg(2+) ion into protoporphyrin IX.

21 we determined the binding site for magnesium protoporphyrin IX.

22 -propionato coordination dimers of iron(III) protoporphyrin IX.

23 like red chlorophyll catabolite or exogenous protoporphyrin IX.

24 ndent conversion of protoporphyrinogen IX to protoporphyrin IX.

25 rotoporphyrinogen IX to the fully conjugated protoporphyrin IX.

26 and was strikingly similar to ferrous (Fe2+) protoporphyrin-IX.

27 Synthetic beta-haematin (FeIII-protoporphyrin-IX)2 is chemically, spectroscopically and

28 ition of heme oxygenase via injection of tin protoporphyrin IX (20 micromol/kg intraperitoneally) res

29 order of magnitude higher than that with Mn protoporphyrin IX (3.3 x 10(6) M(-1) s(-1)), the dissoci

30 imals with the heme oxygenase inhibitor zinc protoporphyrin IX (50 micromol/kg IP) markedly decreased

31 Treatment of the animals with tin protoporphyrin-IX, a global HO inhibitor, or HO-1 small

32 Protoporphyrin IX accumulated in the dysplastic epitheli

33 We report here that protoporphyrin IX accumulates in the mutant embryos, sug

34 Moreover, protoporphyrin IX accumulation in flumioxazin-treated WT

35 eterocyclic herbicide S-23142 causes massive protoporphyrin IX accumulation, resulting in membrane de

36 the Ccm system, and the negative effects of protoporphyrin IX accumulation.

37 changes, but had increased ductular reaction protoporphyrin-IX accumulation, and MDB-preventive K18 i

38 hexylester, EMT6 cells accumulated abundant protoporphyrin IX, an endogenous photosensitizer formed

39 Interestingly, cobalt protoporphyrin IX, an HO-1 inductor, increased the paras

40 Furthermore, zinc protoporphyrin IX, an inhibitor of HO activity, abrogate

41 MGd used in combination with tin protoporphyrin IX, an inhibitor of HO1, resulted in syne

42 and HO-1 and systemic administration of tin-protoporphyrin-IX, an HO inhibitor, abolished these anti

43 EM14C-deficient cells was ameliorated with a protoporphyrin IX analog, indicating that TMEM14C primar

44 ctron donor in solution was examined between protoporphyrin IX and 1-methyl-2-oxomesoheme XIII.

45 ing of photosensitizers in milk (riboflavin, protoporphyrin IX and a chlorophyllic compound) by front

46 uted cytochrome b5 may dissociate to free Mn-protoporphyrin IX and apocytochrome b5.

47 ed Michaelis-Menten kinetics with respect to protoporphyrin IX and BchH.

48 gle-channel activity only in the presence of protoporphyrin IX and blue light.

49 ae, forms a stoichiometric complex with iron protoporphyrin IX and catalyzes the oxygen-dependent con

50 It is suggested that protoporphyrin IX and chlorophyll are responsible for ox

51 port other cyclic planar porphyrins, such as protoporphyrin IX and coproporphyrin.

52 ical, we isolated and characterized the iron protoporphyrin IX and heme a from the reactions of CN(-)

53 ochrome oxidase, suggesting a defect between protoporphyrin IX and heme a.

54 , and N-bromosuccinimide) and was blocked by protoporphyrin IX and hemoglobin but not by Congo red.

55 an accumulation of the chlorophyll precursor protoporphyrin IX and in attenuation of FR-regulated gen

56 of PMA are prevented by the HO inhibitor tin protoporphyrin IX and in cultures from mice with deletio

57 he last enzyme in the heme pathway, chelates protoporphyrin IX and iron to form heme and is mutated i

58 RR data on the binding of free-base protoporphyrin IX and its metalated complexes (Fe(III),

59 rkness drastically increased the level of Mg-protoporphyrin IX and Mg-protoporphyrin IX monomethyl es

60 to be dose dependent and specific for heme; protoporphyrin IX and other heme structural analogs did

61 HO-1 inhibition with tin-protoporphyrin IX and silencing with RNA interference re

62 ssion, and markedly increased levels of free protoporphyrin IX and zinc protoporphyrin are generated

63 lirubin and abolished by incubation with tin protoporphyrin-IX and knock down of nuclear factor-E2-re

64 ators of heme synthesis (succinylacetone and protoporphyrin IX) and cellular iron content (holotransf

65 Proteins containing heme, iron(protoporphyrin IX) and its variants, continue to be one

66 nit of Mg-chelatase, as well as a substrate (protoporphyrin IX) and product (Mg-protoporphyrin IX) of

67 xpression is inhibited by both hemin (ferric protoporphyrin IX) and protoporphyrin IX.

68 ctron-transfer reorganization energies of Zn(protoporphyrin IX) and Zn(octaethylporphyrin) are determ

69 plicated DeltaPsim changes in PCD: ceramide, protoporphyrin IX, and the hypersensitive response elici

70 Heme is a complex of iron with protoporphyrin IX, and the iron-containing structure of

71 ressed BchH proteins contained tightly bound protoporphyrin IX, and they were susceptible to inactiva

72 ed photosensitizers verteporfin, temoporfin, protoporphyrin IX, and trisulfonated hydroxyaluminum pht

73 pi-acceptor compounds (e.g., 1,4-dipyridine, protoporphyrin IX), aromatic compounds (e.g., 1,4-dihydr

74 and identified the chlorophyll precursor Mg-protoporphyrin IX as a key signalling molecule.

75 not show any change in the structure of the protoporphyrin IX as indicated by its MALDI mass spectru

76 oli hemA mutant to employ exogenous hemin or protoporphyrin IX as sole sources of porphyrin.

77 BchD, and BchI) that inserts magnesium into protoporphyrin IX as the first committed step of (bacter

78 1) catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis,

79 tentiated by the HO inhibitors, zinc and tin protoporphyrin-IX as well as by the CO scavenger, hemogl

80 Our previous study has shown that endo-Protoporphyrin IX based SDT (ALA-SDT) could induce apopt

81 titrations demonstrated that both hemin and protoporphyrin IX bind to NikA with similar affinity.

82 nd the Roussin's red salt ester (mu-S,mu-S')-protoporphyrin-IX-bis(2-thioethyl ester)tetranitrosyldii

83 of sheared SMCs with the HO-1 inhibitor, tin protoporphyrin-IX, blocked the antiaggregatory effect of

84 e of human ferrochelatase with the substrate protoporphyrin IX bound as well as a higher resolution s

85 s the ATP-dependent insertion of Mg(2+) into protoporphyrin IX catalyzed by the multisubunit enzyme m

86 onomethyl ester oxidative cyclase (bchE), Mg-protoporphyrin IX chelatase (bchD), and phytoene dehydro

87 Patients with EPP may overproduce protoporphyrin IX, chiefly in developing erythrocytes.

88 en intraperitoneal injections of cobalt(III) protoporphyrin IX chloride (CoPP), which up-regulates HO

89 rats were treated with HO-1 activator cobalt protoporphyrin IX chloride (Copp; 25 mg/kg body weight)

90 For this catalyst and iron protoporphyrin IX chloride, Fe(PPIX)Cl, two distinct and

91 The suppressive effect of HO-1 induction by protoporphyrin IX cobalt chloride (CoPP; a classical ind

92 ated, respectively, by varying the hemin (or protoporphyrin IX) concentration in the medium and by ad

93 Here, we demonstrate that cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnP

94 Cobaltic protoporphyrin IX (CoPP) is a synthetic heme analog whic

95 HO-1 expression by administration of cobalt protoporphyrin IX (CoPPIX) to the graft donor restored g

96 with induction of HO-1 expression by cobalt protoporphyrin IX (CoPPIX).

97 Tin protoporphyrin IX did not affect heme oxygenase-1 expres

98 , and that of the methoxide adduct of ferric protoporphyrin IX dimethyl ester (FeIIIPPIXDME).

99 strates 4-fluorostyrene, vinylferrocene, and protoporphyrin IX dimethyl ester were then coupled (in d

100 The HO-1 inducer cobalt protoporphyrin IX diminished proinflammatory cytokine le

101 Furthermore, upregulation of HO-1 by cobalt protoporphyrin IX diminished the production of TNF-alpha

102 retreatment with aminolevulinic acid or with protoporphyrin IX dramatically increased the light sensi

103 A was found to comigrate with both hemin and protoporphyrin IX during gel filtration.

104 inhibition of HO by a specific inhibitor, Sn-protoporphyrin IX, enhanced chemotaxis.

105 Treatment with the HO-1 inhibitor zinc protoporphyrin IX exacerbated the inflammatory response

106 in, a detoxified, crystalline form of ferric protoporphyrin IX (Fe(3+)-PPIX) produced by the parasite

107 er bonds between the vinyl groups of heme b (protoporphyrin IX-Fe) and the thiol groups of cysteines

108 ocytochromes and the vinyl groups of heme b (protoporphyrin IX-Fe).

109 x +Fe4+=O) and compound II (Fe4+; formally (protoporphyrin-IX)Fe4+=O) were detected.

110 believed to result from accumulation of iron protoporphyrin IX (FePPIX) derived from erythrocytic hem

111 iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (EC 4.99.1.1).

112 at is capable of ultrasensitive detection of protoporphyrin IX fluorescence in vivo, together with in

113 In vivo animal studies reveal that protoporphyrin IX fluorescence is strongly correlated wi

114 These transfectants still require hemin or protoporphyrin IX for growth but produce porphyrin when

115 fen, and by replacement of heme by manganese protoporphyrin IX (forming MnPGHS-1).

116 stant S. aureus and M. smegmatis was gallium protoporphyrin IX (Ga-PPIX).

117 n of transcription by hemoglobin and (cobalt protoporphyrin IX) globin but not by apoglobin or other

118 articularly striking is the structure of the protoporphyrin IX group, which is distorted from planari

119 manganese protoporphyrin IX instead of iron protoporphyrin IX has been investigated by resonance Ram

120 rm whale myoglobin reconstituted with cobalt protoporphyrin IX have been determined by x-ray crystall

121 eins that contain cysteine thiolate-liganded protoporphyrin IX heme prosthetic groups.

122 l genetic systems that allow the use of iron-protoporphyrin IX (heme) have been described for the pat

123 here that the endogenous small molecule iron protoporphyrin IX (hemin) and several related porphyrin

124 associated with heme transport since cobalt-protoporphyrin IX-hemopexin, which binds to the receptor

125 Experiments with protoporphyrin IX in a glioma rodent model demonstrate i

126 e accumulation of the photosensitizing agent protoporphyrin IX in areas of plaque psoriasis by monito

127 vo heme oxygenase enzyme inhibition with tin protoporphyrin IX in common bile duct ligation animals w

128 cy of ferrochelatase (FECH), accumulation of protoporphyrin IX in erythrocytes, skin, and liver, and

129 Mixed-metal hybrids, with zinc protoporphyrin IX in place of heme on both alpha or both

130 xidase (MP) and 2-methylimidazole ligated Fe protoporphyrin IX in the 10 ns to 10 ms time window.

131 Magnesium chelatase inserts Mg2+ into protoporphyrin IX in the chlorophyll and bacteriochlorop

132 s accumulation of the endogenous hepatotoxin protoporphyrin IX in the liver through PXR-mediated alte

133 yl phenotype of laf6 and the accumulation of protoporphyrin IX in the mutant can be recapitulated by

134 es the oxidation of protoporphyrinogen IX to protoporphyrin IX in the penultimate step of heme and ch

135 -aminolevulinic acid, the level of magnesium-protoporphyrin IX increased 60-fold in the PS I-less/chl

136 the characteristic fluorescence emission of protoporphyrin IX increases in intensity within the 6-h

137 f cytochrome b5 reconstituted with manganese protoporphyrin IX instead of iron protoporphyrin IX has

138 es results in a decreased ability to convert protoporphyrin IX into heme, leading to protoporphyria,

139 s-histidyl N delta 1/N epsilon 2-coordinated protoporphyrin IX iron.

140 e and its biosynthetic intermediates such as protoporphyrin IX is a complex and highly coordinated pr

141 Insertion of ferrous iron into protoporphyrin IX is catalyzed by ferrochelatase (EC 4.9

142 ct of the ferrochelatase-catalyzed reaction, protoporphyrin IX is fluorescent, and therefore the prog

143 The ATP-dependent insertion of Mg(2+) into protoporphyrin IX is the first committed step in the chl

144 Hemin (iron protoporphyrin IX) is a crucial component of many physio

145 biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX fer

146 Replacement of the heme group by mangano protoporphyrin IX largely preserves the cyclooxygenase a

147 elevated serum ferritins, elevated red cell protoporphyrin IX levels, and adult-onset neurodegenerat

148 nt with this, we observed increased cellular protoporphyrin IX levels, reduced mitochondrial heme a a

149 nd Q189R was reduced to that of free Fe(III) protoporphyrin IX levels, whereas Q189N catalyzed more r

150 Holocytochrome b5, the protein with iron protoporphyrin-IX liganded to His-39 and His-63, contain

151 Protoporphyrin IX may accumulate, with resultant toxicit

152 ealed accumulation of very high levels of Mg-protoporphyrin IX methyl ester and only traces of protoc

153 me which converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methion

154 th the next enzyme in the pathway, magnesium protoporphyrin IX methyltransferase (BchM).

155 Sll1214 and the Chl biosynthesis enzymes Mg-protoporphyrin IX methyltransferase and protochlorophyll

156 mutation in the bchM gene that codes for Mg-protoporphyrin IX methyltransferase, the enzyme which co

157 cystis genome should similarly code for a Mg-protoporphyrin IX methyltransferase.

158 Accumulation of magnesium-protoporphyrin IX (Mg-Proto), an intermediate in chlorop

159 oroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated interme

160 liana) knockout ntrc reveals lower magnesium protoporphyrin IX (MgP) and MgPMME steady-state levels,

161 m S-adenosyl-L-methionine (SAM) to magnesium protoporphyrin IX (MgP) forming MgP monomethylester (MgP

162 f Mg(2+)-mesoporphyrin IX (MgMPIX) or Mg(2+)-protoporphyrin IX (MgPPIX) located in the heme pocket of

163 teristics of PGHS reconstituted with mangano protoporphyrin IX (Mn-PGHS) to those of the native heme

164 -2) and in PGHS-1 reconstituted with mangano protoporphyrin IX (MnPGHS-1), but the EPR spectra of the

165 ability of a DeltabluB strain to convert Mg-protoporphyrin IX monomethyl ester (MPE) into protochlor

166 Surprisingly, Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase,

167 sed the level of Mg-protoporphyrin IX and Mg-protoporphyrin IX monomethyl ester in the PS I-less/ch/L

168 d strain containing reporter plasmids for Mg-protoporphyrin IX monomethyl ester oxidative cyclase (bc

169 izes 3,8-divinyl protochlorophyllide from Mg-protoporphyrin IX monomethyl ester, Ho1 oxidatively clea

170 reduced amounts of Crd1/CHL27 accumulate Mg-protoporphyrin IX monomethyl ester, the substrate of the

171 e only proton donating/accepting site, using protoporphyrin IX-monomethyl esters (PPIX(MME)) and N-me

172 the chlorophyll biosynthesis intermediate Mg-protoporphyrin IX monomethylester (Mg-proto MME), consis

173 RC stimulates in vitro activity of magnesium protoporphyrin IX monomethylester (MgPMME) cyclase, most

174 nin), coproporphyrinogen III oxidase, and Mg-protoporphyrin IX monomethylester cyclase.

175 The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and I

176 As neither protoporphyrin IX nor coproporphyrin export improved wit

177 ytochrome b5 into the apoprotein and free Mn protoporphyrin IX occurs with a first-order rate constan

178 ubstrate (protoporphyrin IX) and product (Mg-protoporphyrin IX) of Mg-chelatase.

179 ted ion channels to human subjects, applying protoporphyrin IX or its precursor aminolevulinic acid.

180 adjacent metalloporphyrin, +1 for iron(III) protoporphyrin IX or neutral for zinc(II) protoporphyrin

181 Ca(2+) inhibited sGC stimulated by protoporphyrin IX or YC-1 suggesting that inhibition was

182 xidizes to the hexacoordinate hemin (Fe(III)-protoporphyrin IX) or hemichrome form (hemiHtsA) with an

183 The hexacoordinate heme (Fe(II)-protoporphyrin IX) or hemochrome form of holoShp (hemoSh

184 ts; gallium (Ga) or zinc (Zn) complexed with protoporphyrin IX (PP) or mesoprotoporphyrin IX (MP) tha

185 lic disease that causes excess production of protoporphyrin IX (PP-IX), the final biosynthetic precur

186 Hepatic accumulation of protoporphyrin-IX (PP-IX) in erythropoietic protoporphyr

187 pical photosensitizing agents and subsequent protoporphyrin IX (PPIX) accumulation in photodynamic th

188 nanodrug by conjugating the photosensitizer protoporphyrin IX (PpIX) and polyethylene glycol (PEG) w

189 Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular loc

190 clinical use of a natural fluorophore called protoporphyrin IX (PpIX) for image-guided surgical resec

191 grow on media containing the heme precursor protoporphyrin IX (PPIX) in place of heme.

192 ayed metabolism of 5-ALA and accumulation of protoporphyrin IX (PpIX) in the high fluorescence area.

193 at the hemoglobin (Hb) metabolites hemin and protoporphyrin IX (PPIX) interact with the BZ site on th

194 Protoporphyrin IX (PPIX) is considered a conserved endog

195 FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual

196 We also describe BcTSPO-mediated protoporphyrin IX (PpIX) reactions, including catalytic

197 (PCD) triggered by Pseudomonas syringae and protoporphyrin IX (PPIX) treatment.

198 nd the iron, copper, and zinc derivatives of protoporphyrin IX (PPIX) with similar affinities, and ap

199 The level of endogenous photosensitiser, protoporphyrin IX (PPIX), can be enhanced in the cells b

200 is based upon the intracellular synthesis of protoporphyrin IX (PpIX), which absorbs light and target

201 Photodynamic therapy (PDT) with protoporphyrin IX (PpIX), which is endogenously derived

202 ng effects of reovirus therapy combined with protoporphyrin IX (PpIX)-mediated photodynamic therapy o

203 lation of the heme biosynthesis intermediate protoporphyrin IX (PPIX).

204 of the tissue in to a photosensitizer called protoporphyrin IX (PPIX).

205 nic acid (ALA) to induce the accumulation of protoporphyrin IX (PpIX).

206 accumulation of the phototoxic intermediate protoporphyrin IX (PPIX).

207 and iron pathways, associated with elevated protoporphyrin IX (PPIX).

208 ccumulation of the PDT-activated ALA product protoporphyrin-IX (PpIX) up to 10-fold, mainly by alteri

209 capable of binding the metalloporphyrin zinc protoporphyrin IX ((PPIX)Zn) have been synthesized.

210 wing the direct fluorescent determination of protoporphyrin IX produced.

211 are features of the iron heme active site: a protoporphyrin IX prosthetic group is linked to the prot

212 wn laf6 seedlings also showed an increase in protoporphyrin IX (Proto IX), Mg-proto, Mg-proto MME and

213 ulinic acid (ALA) causes cells to accumulate protoporphyrin IX (Proto) and heme.

214 Structural determinations of Co(3+)-protoporphyrin IX-reconstituted muCOX-2 with alpha-linol

215 d docosahexaenoic acid (DHA) bound to Co(3+)-protoporphyrin IX-reconstituted murine COX-2 to 2.1, 2.4

216 in the cyclooxygenase active site of Co(3+) protoporphyrin IX-reconstituted ovine PGHS-1 (Co(3+)-oPG

217 Hemin, but not protoporphyrin IX, restored bacterial growth in iron-lim

218 I) protoporphyrin IX or neutral for zinc(II) protoporphyrin IX resulted in a loss of 70 mV [Fe(III)PP

219 lyzes the insertion of ferrous iron into the protoporphyrin IX ring.

220 Irradiation of aminolevulinic acid/protoporphyrin IX-sensitized cells with 10 J cm(-2) of 5

221 Thus, mangano protoporphyrin IX serves as a useful tool to evaluate th

222 In contrast, HO-1 agonists hemin and cobalt protoporphyrin IX significantly increased DAF protein ex

223 HO-1 induction with metalloporphyrin cobalt protoporphyrin IX significantly reduces the loss of body

224 (+) We observed that HO inhibition using tin protoporphyrin IX (SnPP) decreased heme-iron recycling i

225 and absence of neurohumoral inhibitors (tin protoporphyrin IX [SnPP IX] for CO synthesis, N(omega)-n

226 was induced in vivo by treatment with cobalt protoporphyrin IX, starting at week 5 or 12 of mice life

227 run-off assays showed that the sGC activator protoporphyrin IX stimulates transcription of the gamma-

228 istent with a high-spin hexacoordinate MnIII protoporphyrin IX structure that converted to a high-spi

229 with BchM in Escherichia coli overproducing protoporphyrin IX suggests that the chelatase is the rat

230 Protoporphyrin IX synthesis in TMEM14C-deficient erythro

231 ee chelatase complexes insert magnesium into protoporphyrin IX, the activities range by a factor of 1

232 conversion of protoporphyrin IX to magnesium protoporphyrin IX, the first committed step of chlorophy

233 Studies of the binding of MnIII protoporphyrin IX to apocytochrome b5 indicated that the

234 vating Mg-chelatase, the enzyme that commits protoporphyrin IX to chlorophyll biosynthesis.

235 catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme.

236 y in ferrochelatase, which chelates iron and protoporphyrin IX to form heme.

237 hat catalyzes chelation of ferrous iron into protoporphyrin IX to form heme.

238 catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme.

239 mpaired (by replacement of heme with mangano protoporphyrin IX to form MnPGHS-1 and -2).

240 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme).

241 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme).

242 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.

243 ynthesis, the insertion of ferrous iron into protoporphyrin IX to form protoheme, is catalyzed by the

244 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme.

245 valent cobalt, zinc, nickel, and copper into protoporphyrin IX to form the corresponding metalloporph

246 zyme catalyzes in vivo Fe(2+) chelation into protoporphyrin IX to give heme.

247 Zea mays) are deficient in the conversion of protoporphyrin IX to magnesium protoporphyrin IX, the fi

248 hyltransferase, the enzyme which converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester us

249 lei Pharmacological administration of cobalt protoporphyrin IX to mice resulted in an enhanced bacter

250 inclusion bodies and reconstituted with iron protoporphyrin IX to obtain the ferric form of the holop

251 lyze the insertion of the imported iron into protoporphyrin IX to produce heme.

252 Concomitantly, upon cobalt protoporphyrin IX treatment, there is a significant upre

253 HCR24 and HO-1 small interfering RNA and tin-protoporphyrin-IX treatment abolished these effects.

254 ells with HO-1 small interfering RNA and tin-protoporphyrin-IX treatment did not inhibit the (A-I)rHD

255 ologic induction of HMOX-1 in vivo by cobalt protoporphyrin-IX treatment eradicated intestinal inflam

256 he physiological substrates ferrous iron and protoporphyrin IX under strictly anaerobic conditions.

257 The crystal structure of Co3+-protoporphyrin IX V349A/W387F oPGHS-1 in a complex with

258 ggesting that the protein matrix rather than protoporphyrin IX was attacked by the cyanyl radical.

259 f the endogenously generated photosensitiser protoporphyrin IX was measured with quantitative fluores

260 ible drug-induced precipitation of iron(III) protoporphyrin IX was postulated to account for this.

261 ose, weighted to the absorption spectrum for protoporphyrin IX, was calculated.

262 ion of the fluorescent tetrapyrrole product, protoporphyrin IX, was detected using a fluorescence pla

263 Hemin and protoporphyrin IX were found to form a complex with acri

264 measurement of oxidative stress markers and protoporphyrin-IX were performed.

265 cid ring A and 5-aminolevulinic acid-induced protoporphyrin IX, were studied.

266 catalyzes the insertion of a Mg(2+) ion into protoporphyrin IX, which can be considered as the first

267 alpha or the beta subunits replaced by zinc protoporphyrin IX, which is unable to bind a ligand and

268 or the transport and correct distribution of protoporphyrin IX, which may act as a light-specific sig

269 of PGHS-1 reconstituted with heme or mangano protoporphyrin IX with a lipid hydroperoxide, 15-hydrope

270 Although PfHO bound heme and protoporphyrin IX with modest affinity, it did not catal

271 akly electron-polarizing 2,4-vinyl groups of protoporphyrin IX with strongly electron-polarizing acet

272 the negative controls, while rose bengal or protoporphyrin IX with visible light were the positive c

273 transfer from flavin to the lower potential protoporphyrin IX, with an unfavorable free energy, can

274 We observed that BchM uses protoporphyrin IX without bound metal as a substrate.

275 eroxide (EtOOH), compound I (Fe5+; formally (protoporphyrin-IX) x +Fe4+=O) and compound II (Fe4+; for

276 tion of heme oxygenase1 (HO-1) activity with protoporphyrin IX zinc(II) blocked MLP nuclear accumulat

277 hat cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly

278 Zinc protoporphyrin IX (ZnPP), an endogenous heme analogue th

279 atment of ganglia with the HO inhibitor zinc protoporphyrin-IX (ZnPP) (10 microm) completely and irre

280 The zinc(II)-protoporphyrin IX (ZnPPIX) fluorophore binds to G-quadru

281 complex with a heme analog, zinc-substituted protoporphyrin IX (ZnPPIX).

282 lated when HO-1 activity was blocked by zinc protoporphyrin IX (ZnPPIX).