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1 served LRH-1/beta-catenin interaction may be prototypic.
4 y CD6, selected for binding to the NA of the prototypic A(H1N1)pdm09 virus, A/California/07/2009, pro
8 ased in patients with alcoholic hepatitis, a prototypic acute-on-chronic condition; and its expressio
11 pha-Galactosylceramide (alpha-GalCer) is the prototypic agonist, but its excessive potency with simul
14 ed by airway challenge to subtilisin induces prototypic allergic lung inflammation, characterized by
15 Binding and structural studies, focused on a prototypic allo-HLA-A2-restricted T-cell receptor (TCR)
16 shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-
18 B-cell pool is enriched for cells expressing prototypic ANA heavy chains in these mice in a non-autoi
20 clude that developmental diversity positions prototypic and arkypallidal neurons to fulfil distinct r
21 he peptide library was then used to identify prototypic and quantotypic peptides to proceed with MRM
23 GABAergic GPe projection neuron, so-called 'prototypic' and 'arkypallidal' neurons, that have differ
24 ry T cells (Tregs) are generally regarded as prototypic anti-inflammatory cells that maintain immune
27 t interact with the glycoproteins (GPs) of a prototypic arenavirus and hantavirus and show that the l
28 he generation of recombinant versions of the prototypic arenavirus LCMV encoding codon-deoptimized vi
30 ursor (GPC) loci within the S segment of the prototypic arenavirus lymphocytic choriomeningitis virus
31 nce indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus
32 We recoded the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus
33 nce indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus
34 ence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus
35 ion (homotypic interaction) of the NP of the prototypic arenavirus lymphocytic choriomeningitis virus
36 e characterized the NP-Z interaction for the prototypic arenavirus lymphocytic choriomeningitis virus
38 tly prevented the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus
41 nce indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus
42 Here, we investigated the ability of the prototypic arenavirus lymphocytic choriomeningitis virus
45 nce indicates that the worldwide-distributed prototypic arenavirus, lymphocytic choriomeningitis viru
51 erythematosus (SLE) is considered to be the prototypic autoimmune disease, with a complex genetic ar
54 mes for two primordial T-cell lineages and a prototypic B-cell lineage were already present in the la
57 n a century of use in clinical practice, the prototypic binding site for this class of drugs within p
58 CR3 and MUT4, were designed and tested, and prototypic bispecific Abs directed against CD5 and HLA-D
60 nt of TeNT entry into CNS neurons, using the prototypic BoNT serotype A as a reference for SV2-mediat
61 etermined whether SIRT1 is downstream of the prototypic c-MYC oncogene, which is activated in the maj
62 oceria, in order to detect the expression of prototypic cancer biomarkers at pH 7.0, such as the fola
63 ugs: 1) metformin and 2) cimetidine; and two prototypic cationic substrates, 3) 1-methyl-4-phenylpyri
71 hat Chitinase 3-like-1 (Chi3l1), a conserved prototypic chitinase-like protein, is induced by Strepto
74 ies with the M3 muscarinic receptor (M3R), a prototypic class A GPCR, that the M3R is able to form mu
76 yne 1,3-dipolar Huisgen's cycloaddition, the prototypic click reaction, presents a promising opportun
84 nalysis of resting-state fMRI measurements-a prototypic data modality that exhibits variable levels o
89 present the mechanistic analysis of PglC, a prototypic dual domain PGT from Campylobacter concisus U
93 acterization of these enzymes along with the prototypic enzyme Sfp from Bacillus subtilis demonstrate
94 encodes a member of the reticulon family of prototypic ER-shaping proteins, in families with spastic
96 -damaging agent mitomycin C, argue that this prototypic eukaryotic member of the MORC superfamily has
97 suppressor genes by homozygous deletion is a prototypic event in the cancer genome, yet such deletion
102 hereditary cardiomyopathies are discussed as prototypic examples of single-gene disorders, including
104 profibrotic cytokine that is elevated in the prototypic fibrotic autoimmune condition systemic sclero
105 Our results provide insights into how a prototypic flavivirus, yellow fever virus (YFV-17D), dif
106 ependent long-term depression (NMDAR-LTD), a prototypic form of synaptic plasticity, is accompanied b
107 ince early in life, have been considered the prototypic forms of genetic defects of T-cell developmen
108 py of the minor rs12459419T allele decreases prototypic full-length CD33 expression by approximately
110 upratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respect
111 ly unfold the mammalian membrane protein and prototypic G protein coupled receptor rhodopsin, without
112 the beta2-adrenergic receptor (beta2-AR), a prototypic G-protein coupled receptor (GPCR), using epin
115 explored possible activation pathways of the prototypic GPCR bovine rhodopsin by means of biased mole
116 alpha2B-adrenergic receptor (alpha2B-AR), a prototypic GPCR, and studied the underlying mechanisms.
117 onnectivities, a network of arkypallidal and prototypic GPe neurons comprises a neural substrate capa
120 ors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases
124 in an experimental endocarditis model, using prototypic healthcare- and community-associated MRSA par
125 ollicular helper T cells (TFH cells) are the prototypic helper T cell subset specialized to enable B
126 e causative agent of chronic hepatitis B and prototypic hepadnavirus, is a small DNA virus that repli
128 ficiency was significantly lower compared to prototypic "highly macrophage-tropic" virus strains.
130 by a mechanism similar to that shown by the prototypic HJ resolvase, Escherichia coli RuvC protein,
135 Here, we characterized the interaction of a prototypic human antibody that acquires binding potentia
142 d to be markedly more potent than the parent prototypic inhibitor in the inhibition of eIF4E/eIF4G in
143 on of a series of rigidified mimetic of this prototypic inhibitor in which the phenyl in the 2-(4-(3,
147 results in podocyte damage, cell loss, and a prototypic injury response called focal segmental glomer
149 ytic necessity for the first time, using the prototypic invertebrate representative twitchin (UNC-22)
150 g protein 1) transcription factor c-Jun is a prototypic JNK target and important regulator of hepatoc
151 he La module is at present restricted to the prototypic La protein, which acts as an RNA chaperone bi
154 wined with VEGFR2 surface recognition by its prototypic ligand VEGF-A and its noncanonical ligand gre
157 Tc17 cells express high levels of multiple prototypic lineage-defining transcription factors (eg, R
160 op an enhanced functional profile beyond the prototypic M1, characterized by an even more potent proi
161 and expression of a set of genes involved in prototypic macrophage functions was quantified using rea
163 Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialyl
164 aracteristics of the responses elicited by a prototypic MAPK, Fus3, in the mating pheromone response
167 solved by the identification of Skint-1, the prototypic member of a novel B7-related multigene family
168 acellular signal-regulated kinase (ERK) is a prototypic member of a serine/threonine protein kinase f
173 the angiotensin II type 1 receptor (AT1R), a prototypic member of the G protein-coupled receptor supe
176 While corticotrophin releasing factor is the prototypic member of this class, recent work has identif
177 -constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor.
180 acterial endotoxin, lipopolysaccharide, is a prototypic microbe-derived inflammatory signal that cont
181 the exposure to mating pheromone activates a prototypic mitogen-activated protein kinase (MAPK) casca
184 Based on experimental evidence we propose a prototypic model that focuses on the dynamics of hair ma
187 designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine sp
188 irected transgenic (sd-tg) mice expressing a prototypic NAA, we investigated the effect of NAA and NA
190 suppressor, is required for the entry of the prototypic negative-strand RNA virus, including influenz
191 eral sclerosis, Parkinson's disease, and the prototypic neuroinflammatory disease multiple sclerosis
193 dopamine-intact rats, molecularly identified prototypic neurons fired at relatively high rates and wi
194 rganization, as actioned by arkypallidal and prototypic neurons with specialized molecular, structura
195 s fired at lower rates and regularities than prototypic neurons, and the two cell types could be furt
196 ro was slower and more variable than that of prototypic neurons, which tallied with arkypallidal neur
199 d Mvarphis, yet the binding of p65/RelA (the prototypic NF-kappaB family member) was reduced at IL-6
200 The efficacy of glycolipids, such as the prototypic NKT cell antagonist alpha-galactosylceramide
201 rotein of vesicular stomatitis virus (VSV, a prototypic NNS RNA virus) to examine participation of th
204 d to 10-50% of normal the levels of mRNA for prototypic Nrf2-regulated enzymes, including the glutama
205 Using vesicular stomatitis virus (VSV), a prototypic NS RNA virus in the family Rhabdoviridae, we
206 Toward this end, fur was deleted in the prototypic NTHi clinical isolate, 86-028NP, and we asses
207 nt study, we investigated the ability of the prototypic Old World arenavirus lymphocytic choriomening
209 onceptually, some of these changes behave as prototypic oncogenic addiction loops, being ideal biomar
210 been reported that invasive aspergillosis, a prototypic opportunistic infection in neutropenic hosts,
212 Epidermolysis bullosa acquisita (EBA) is a prototypic organ-specific autoimmune disease induced by
213 sh larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon.
215 omerization domain-like receptors (NLRs) are prototypic pattern recognition receptors that detect ext
216 studied the minimal fusion requirements of a prototypic phlebovirus, Uukuniemi virus, in an in vitro
220 te conformation of GLIC, currently used as a prototypic pLGIC, and opens new avenues to study the sig
227 tructurally nonrelevant modifications of the prototypic proinflammatory cytokine IL-1beta during an i
230 he single-molecule level the activity of the prototypic proton-pumping P-type ATPase Arabidopsis thal
233 ical transformation is rapidly emerging as a prototypic, redox-based post-translational modification
234 angiopoietin/Tie ligand/receptor system is a prototypic regulator of vessel remodeling and maturation
235 developed a fusion protein consisting of two prototypic regulatory cytokines, interleukin 4 (IL4) and
237 approach, we have generated and validated a prototypic reverse diagnosis catalog for the MMR gene Mu
238 ggested that formation of a complex with the prototypic RNase H inhibitor beta-thujaplicinol is slow,
242 these cells share common hallmarks with the prototypic SCs in somite-derived muscles, they distincti
247 like behaviors that are not rescued with the prototypic selective serotonin reuptake inhibitor (SSRI)
248 ction relationships of Antigen 43 (Ag43a), a prototypic self-associating AT protein from uropathogeni
249 roteins and that the function defined by the prototypic SelK is the widespread function of selenium i
250 n this disease are small bile ducts, and the prototypic serologic response includes antimitochondrial
252 ctive agent in this in vitro cell assay, the prototypic sigma 1 receptor agonist (+)-pentazocine was
253 of the beta-2 adrenergic receptor (B2AR), a prototypic signaling receptor, between sequence-dependen
254 NALE: Hypertrophic cardiomyopathy (HCM) is a prototypic single-gene disease caused mainly by mutation
255 at clearly was morphologically distinct from prototypic SIV encephalitis and human immunodeficiency v
258 e of yeast mgt1Delta rad52Delta cells to the prototypic Sn1-type methylating agent N-methyl-N'-nitro-
259 medial amygdala (MeA) has been implicated in prototypic social behaviors such as aggression, the circ
260 evidence suggest that L. pneumophila lacks a prototypic SOS response and competence development in re
261 ost-interacting effector proteins from these prototypic strains has led to the discovery of novel pos
262 fections is based on the study of one or two prototypic strains that have provided deep insight into
263 acellular signal-regulated kinase (ERK) is a prototypic subclass of MAPKs and is densely expressed in
264 t Fbw7-dependent regulation of cyclin E, its prototypic substrate, and to examine the consequences of
265 oxidations of nifedipine and quinidine, two prototypic substrates, in liver microsomes and a reconst
267 Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, is a debilitatin
268 es elicited by T cells via engagement of the prototypic T cell costimulatory receptor CD28 by the cog
270 and conventional DCs, we found that CD28, a prototypic T cell stimulatory receptor, was highly expre
272 affinity maturation of antibodies against a prototypic T-dependent B. burgdorferi protein, Arthritis
273 c Escherichia coli bundle-forming pilus is a prototypic T4P assembled and powered by BfpD, a conserve
275 behavior of T cells with specificity for the prototypic TEIPP antigen, the "self" TRH4 peptide/Db com
276 by dendritic cell IL-12 and IL-10, which are prototypic Th1 and regulatory T cell polarizing cytokine
277 increased transcripts and expression of the prototypic TH1 genes Eomesodermin, IFN-gamma, T-box tran
278 N is essential for host resistance against a prototypic Th1 pathogen, Toxoplasma gondii, and for the
280 effector functions that are inhibited by the prototypic Th2 cytokine IL4 and the TGFbeta superfamily
285 ne doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding s
286 used single-channel optical analysis of the prototypic transmembrane beta-barrel alpha-hemolysin (al
288 quantification concatamer (QconCAT) carrying prototypic tryptic peptides of UCH-L1 was used as an int
290 reactive V3 NAbs elicited by vaccination and prototypic V3 NAbs derived from natural infections in hu
292 is also reported to be less sensitive to the prototypic viral antagonist human immunodeficiency virus
293 ised against E7 from human papillomavirus, a prototypic viral oncoprotein and a model intrinsically d
294 ciency virus type 1 (HIV-1) Vpu protein, the prototypic viral tetherin antagonist, in rescuing HIV-1
295 The positive-stranded RNA genome of the prototypic virulence-attenuating hypovirus CHV-1/EP713 c
297 suppressor PTEN to the voltage sensor of the prototypic VSP from Ciona intestinalis, Ci-VSP, we gener
299 n with the ferret-adapted CDV(5804P) and the prototypic wild-type CDV(R252) showed that hematogenous
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