ライフサイエンスコーパス: protrusion

1 beta-Pix, which activates Cdc42 and promotes protrusion.

2 tenuation of RF at sites of forward membrane protrusion.

3 y serving as a physical barrier that opposes protrusion.

4 e flow (RF) to promote leading edge membrane protrusion.

5 ilure in formation of the dorsal mesenchymal protrusion.

6 actin assembly and resulting consequences on protrusion.

7 amics, often resulting in traveling waves of protrusion.

8 scosity-adhesion length, and a rate of actin protrusion.

9 a symmetrical elongated lens to a spherical protrusion.

10 herent keratocytes from waving to persistent protrusion.

11 formation, and (iii) the rapid growth of new protrusions.

12 A gel induced Arp2/3-dependent lamellipodial protrusions.

13 ility to support the localization of RNAs at protrusions.

14 nsistent with that observed in lamellipodial protrusions.

15 of symmetry) and the shoulder of the 3-fold protrusions.

16 lates with formation and elongation of actin protrusions.

17 e PLS and is required for p190A targeting to protrusions.

18 nhance the formation and elongation of actin protrusions.

19 42 activities during the extension of random protrusions.

20 aining RhoB nanoclusters and plasma membrane protrusions.

21 the cytokinetic furrow and the base of cell protrusions.

22 ses responsible for p190A targeting to actin protrusions.

23 tein concentration along flexible filopodial protrusions.

24 local alignment of adhesions and individual protrusions.

25 each other via lateral contacts and/or basal protrusions.

26 h kinetics and membrane shape can yield such protrusions.

27 e membrane in surface reservoirs of pits and protrusions.

28 ing RhoA activity to predominate in invasive protrusions.

29 ve physical interactions between neighboring protrusions.

30 kely that only fascin bundles actin in these protrusions.

31 d form collar-like structures at the base of protrusions.

32 linositol 3,4,5-trisphosphate (PIP3) to form protrusions.

33 d levels of ActA on the bacterial surface in protrusions.

34 persistence specifically within EC branched protrusions.

35 ciated F-actin that precede the extension of protrusions.

36 the early stage of the formation of internal protrusions.

37 EspW results in formation of unique membrane protrusions.

38 rotein controls localization of some RNAs at protrusions.

39 ar structures, including actin-based dynamic protrusions.

40 2/3 complex to induce Rac1-mediated membrane protrusions.

41 obust and active formation and retraction of protrusions.

42 inducing formation of the microtubule-based protrusions.

43 y two domains residing on Sth1 (Post-HSA and Protrusion 1) and by actin-related proteins (ARPs) that

44 dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-s

45 Examination of the distribution of cell protrusions (adhesion to the substrate) in the model pre

46 In these contexts, protrusions adopt lamellipodia or an amoeboid morphology

47 orm and position distinct classes of dynamic protrusion along the apicobasal axis of the cell.

48 Dendritic spines are protrusions along neuronal dendrites that harbor the maj

49 n the ECM and 3) cells preferentially extend protrusions along the strain orientation.

50 in-dependent pathway that builds an invasive protrusion, an isolated lysosome-derived membrane struct

51 Despite protrusion and actin assembly defects, Arpc2(-/-) macrop

52 scade to promote Rac1-mediated lamellipodial protrusion and FA turnover.

53 omotes cell migration by supporting membrane protrusion and focal adhesion stability.

54 quires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extrace

55 ptation of ingestive mouth movements (tongue protrusion and lip smacking) for the purposes of social

56 eukocyte rolling on the endothelium, surface protrusion and membrane tether extraction occur consecut

57 ntegrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation

58 s cell:cell junctions and increases membrane protrusion and overall cell motility.

59 Mena11a can dampen membrane protrusion and reduce actin polymerization in the absenc

60 adigmatic orofacial "gesture," namely tongue protrusion and retraction (TP/R).

61 Protrusion and retraction of lamellipodia are common fea

62 nters the retraction, and the balance of the protrusion and retraction shapes the lamellipodium.

63 Both surface protrusion and tether extraction of leukocytes stabilize

64 is ascribed to the growing condition of the protrusion and the gap filling process.

65 hat RIN1 affects the morphology of dendritic protrusions and accelerates dendritic filopodial motilit

66 ortance, Tpm3.1 is enriched in the dendritic protrusions and cortical actin of melanocytes, where myo

67 ation in mice to determine that both villous protrusions and floating cysts contribute to PEC translo

68 ss, lost polarity and failed to form villous protrusions and floating cysts.

69 eptor Patched is localized in these cellular protrusions and Hh reception takes place in membrane con

70 of branched actin networks powers cell-edge protrusions and motility.

71 ion promotes enrichment of DOCK5 in membrane protrusions and nascent cell-substratum adhesions.

72 zation of specific RNAs from fibroblast cell protrusions and neuronal axons.

73 ers constrict the nucleus, causing chromatin protrusions and nuclear membrane ruptures at sites with

74 y reported mechanisms based on lamellipodial protrusions and purse-string contraction, our data revea

75 nteraction with the WRC disrupts tricellular protrusions and results in the formation of nonpolarized

76 onization of the leading and trailing cells' protrusions and retractions (motility cycles) aided by t

77 ks control cellular dynamics by coordinating protrusions and retractions in space and time.

78 nt in the formation and turnover of synaptic protrusions and synapses of young brain after neuronal m

79 stresses in follower row cells, misdirected protrusions and the formation of actin stress fibers anc

80 roteins to promote the formation of cellular protrusions and to stimulate invasive migration.

81 t RNAs become enriched in high-contractility protrusions and, accordingly, their localization is prom

82 n of actin, results in asymmetrical membrane protrusions and, ultimately, the closure of the aperture

83 headache, hypertension, intervertebral disc protrusion, and malignant lung neoplasm in the acetylcys

84 ment, including actin dynamics, lamellipodia protrusion, and membrane ruffling.

85 , identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of n

86 rounded by the beta' clamp helices, the beta protrusion, and the beta lobe domains to close the promo

87 ed twelve-fold symmetry, concentric flanking protrusions, and a central electron density.

88 clusters is regulated by subcellular forces, protrusions, and adhesions for varying ECM inputs, such

89 differentially enriched in distinct types of protrusions, and are additionally differentially depende

90 etics on flattened membranes and on cellular protrusions, and does not transfer between cells in clos

91 flatness, increased filamentous actin-based protrusions, and increased signal transduction network a

92 actin, causes formation of microtubule-based protrusions, and increases pathogen adherence.

93 g formation of invadopodia and cell-membrane protrusions, and removal of BM.

94 by wide gaps, they are connected by filiform protrusions, and their migration depends on C-cadherin a

95 DrDps1 N-terminal protrusions appear to be directly involved with DNA, whi

96 Tubular protrusions are a common feature of living cells, arisin

97 rvature associated with the tips of cellular protrusions as intuitively expected.

98 During protrusion, as membrane tension increases, velocity slow

99 ing embryo cell expansion leading to radicle protrusion, as well as endosperm weakening prior to its

100 y a leading role in the generation of random protrusions, as we observed an initial strong activation

101 zation and growth factor-stimulated membrane protrusion at lamellipodia.

102 Actin protrusion at the boundary counters the retraction, and

103 ort the existence of finger-like actin-based protrusions at fusion sites in vertebrates that were not

104 in the accumulation of atoms accompanied by protrusions at the anode and atomic depletion causing vo

105 We consistently observed a protrusion between hindlimb and forelimb representation,

106 xcess is stored in a population of bleb-like protrusions (BLiPs), whose size distribution is shown by

107 anning 100 ms to seconds that correlate with protrusions but not predominately the positive curvature

108 s the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional

109 Numerous RNAs are enriched within cellular protrusions, but the underlying mechanisms are largely u

110 central role for cell adhesion and membrane protrusion by directly binding and recruiting paxillin t

111 ting integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with t

112 en implicated in the formation of actin-rich protrusions by macrophages, but their individual activat

113 to the vascular endothelium through adhesive protrusions called "knobs" that the parasite induces on

114 carcinoma cells use specialized, actin-rich protrusions called invadopodia to degrade and invade thr

115 The latter mode is supported by thin tubular protrusions, called nanotunnels, that contact other mito

116 re short viscosity-adhesion lengths and fast protrusion cause an accumulation of myosin in a small re

117 Thereby, Lpd supports lamellipodia protrusion, cell migration and endocytosis.

118 This relative size of the genital protrusion co-varied with relative testicle size, an ind

119 tein-coupled receptor at actin-rich cellular protrusions containing VASP, a filopodial marker.

120 oupled to ECM signaling that is modulated by protrusion/contraction.

121 podia and filopodia are dynamic, actin-based protrusions contributing to cancer cell migration, invas

122 Cellular protrusions controlled by Eph/Ephrin signaling mediate h

123 Consistent with the idea that this protrusion corresponds to genital cortex, we observed a

124 n expression promotes elongation and reduces protrusion density in cells with relatively lower L-plas

125 We show that the rapid expansion of the protrusion depends on membrane invaginations that are lo

126 uperfamily protein Fat2 regulates actin-rich protrusions driving collective cell migration during Dro

127 adhesions-along with lateral propagation of protrusion due to the branched architecture of the actin

128 cortex, we observed a size increase of this protrusion during puberty.

129 equired for the maintenance of lamellipodial protrusions during electrotaxis via electric field-activ

130 vivo, supporting a potential role for these protrusions during tumorigenesis.

131 contact guidance, we analyze quantitatively protrusion dynamics and find that the structured ECM ori

132 Differences in adhesion and protrusion dynamics were mediated by balancing the activ

133 extract quantifiable information, including protrusion dynamics, density, and length, from multiple

134 tin polymerases operating at their tips, the protrusion efficiency of lamellipodia is determined by a

135 he same time, network architecture tunes the protrusion efficiency, and regulates the rate of growth.

136 Protrusions, efflorescence, delamination, and opacity de

137 microtubules directly drive plasma membrane protrusion, either in the course of polymerization or mo

138 Using mouse embryos, we show that cell protrusions emanating from the apposed neural fold tips,

139 a4 relieves intercellular tension to promote protrusion engulfment, which represents a distinctive st

140 ffector of spread that specifically promotes protrusion engulfment.

141 tes of cells treated with zinc, and membrane protrusions enriched in zinc were detected on whole cell

142 scale allows identification of active areas (protrusions, flat film surface, or cracks) responsible f

143 nt that promote actin-mediated lamellipodial protrusion followed by the formation of nascent integrin

144 zation of actin cytoskeleton and actin-based protrusions for myoblast fusion in mammals and its requi

145 olarity proteins, with consequent changes in protrusion form and position and additionally show, usin

146 is the level of Rac activity that determines protrusion form.

147 g to skip over gaps in adhesive area, biases protrusion formation along fibers.

148 n but abolishes the ability to enhance actin protrusion formation and elongation in COS7 cells.

149 process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape.

150 septins (SEPT) are essential for CDT-induced protrusion formation.

151 hlorfenuron or knockdown of septins inhibits protrusion formation.

152 The 3' ssDNA protrusion formed through resection activates the ATR-de

153 where distinct types of actin-based membrane protrusions formed.

154 The extending and revolving protrusion forms the carbide shell.

155 Following the breach, a large protrusion forms to clear a path for tissue entry by poo

156 ular protrusions in form of blebs, a type of protrusion found in various cell types.

157 ulling force on the EC, simultaneous surface protrusion from both cells occurred, and it can be model

158 FICANCE STATEMENT Dendritic spines are small protrusions from neuronal dendrites that make synapses w

159 Dendritic spines are small protrusions from neuronal dendrites where the postsynapt

160 at the neck of the protrusion, which enables protrusion growth.

161 reduced during tail retraction, and specific protrusions had reduced Cdc42 activity.

162 opmental and neural basis of neonatal tongue protrusion has important implications for current unders

163 rs and its influence on the effectiveness of protrusion have been unclear.

164 nificant residual intrastent plaque/thrombus protrusion (hazard ratio [HR], 2.35; P<0.01), in-stent m

165 and the residual intrastent plaque/thrombus protrusion (HR, 2.83; P=0.008) were confirmed as indepen

166 in cell morphology, observed as cytoskeleton protrusions-i.e., lamellipodia and filopodia-were reduce

167 Blebs are pressure-driven cell protrusions implicated in cellular functions such as cel

168 of invadopodia, actin-rich matrix degrading protrusions, important for tumor cell invasion and trans

169 osterior staphylomas, lateral angulation, or protrusion in all eyes.

170 sexual monomorphism of the putative genital protrusion in all species, similar to previous observati

171 variants but not VASP reduced lamellipodial protrusion in B16-F1 cells, albeit to variable extents.

172 universal mechanism to drive plasma membrane protrusion in motile cells.

173 e observed an unexpected phenotype of spinal protrusion in Nkx3.1:Cre;Erk5 (fl/fl) (Erk5 (fl/fl)) mic

174 ment of GFP-NM-IIA filaments to leading edge protrusions in 2D, and this in turn blocks maturation of

175 evere defects in invasion and in stabilizing protrusions in 3D.

176 able ImageJ plugin, to detect filopodia-like protrusions in both fixed- and live-cell microscopy data

177 l junctions and the formation of basolateral protrusions in distinct subsets of hypodermal cells.

178 gration depends on the formation of cellular protrusions in form of blebs, a type of protrusion found

179 ar lamina, and the HER2 receptor on membrane protrusions in human breast cancer specimens.

180 combinations of both, or absence of any such protrusions in MCF-7 cells.

181 piston, switching from low- to high-pressure protrusions in response to the surrounding three-dimensi

182 cell's trailing edge to induce leading edge protrusions in the cell behind, in part by stabilizing L

183 Actin polymerization-based protrusion increases tension in the plasma membrane, whi

184 observe Cdc42 and Rac1 activity in cellular protrusions, indicating that Rac1 but not Cdc42 activity

185 omatic relief and complications such as tube protrusion, infection, persistent bleeding, and return t

186 ading-edge enrichment greatest just prior to protrusion initiation.

187 tend vimentin intermediate filament-enriched protrusions into the 3D ECM.

188 depleted cells lacked the ability to sustain protrusions into the subendothelial matrix in contrast w

189 The resolution of membrane protrusions into vacuoles from which the pathogen escape

190 Furthermore, we discovered novel podocyte protrusions invading into the glomerular basement membra

191 Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadopodia), which

192 Therefore, EC surface protrusion is an important aspect of leukocyte rolling,

193 Live-cell imaging revealed that the protrusion is enriched in the matrix metalloprotease ZMP

194 Matching of tongue-protrusion is not imitation, but a manifestation of the

195 can modulate the rate and the direction of a protrusion, is by varying both density and architecture

196 Here, using protrusion-isolation schemes and RNA-Seq, we find that R

197 Adherence is mediated by membrane protrusions known as knobs, whose formation depends on t

198 it to play an important role in stable actin protrusion length and ultrastructure maintenance.

199 ey can switch between high- and low-pressure protrusions like primary fibroblasts.

200 ntified a novel functional p190A domain: the protrusion localization sequence (PLS) necessary and suf

201 ogy of these cells, with broad lamellipodial protrusions, mature focal adhesions and a gradient of ac

202 in regulator Cortactin, a major organizer of protrusion, membrane mobility, and invasiveness, and def

203 y of dynamic cellular events, including cell protrusion, migration, proliferation, and cell-fate dete

204 AOK2 depletion results in unstable dendritic protrusions, mislocalized shaft-synapses, and loss of co

205 tages of nymphal development, while odontoid protrusions more prominent in the female than in the mal

206 Regulation of cellular protrusions, movement and intercalation within the cochl

207 ), culotte (n=5), modified-T (n=5), or T-and protrusion (n=5) stenting techniques.

208 americ sphere, contrasting strongly with the protrusions observed in the full-length models.

209 are normally characterized by the persistent protrusion of a broad leading edge, increasing cell-subs

210 ubstrate adhesion strength results in waving protrusion of a short leading edge.

211 tion and cell-cell communication involve the protrusion of actin-rich cell surface projections such a

212 tropic matrix is able to guide the dendritic protrusion of cells.

213 ed from endothelial cells (ECs), but surface protrusion of ECs has never been confirmed to exist.

214 an of the lumbar spine which only revealed a protrusion of the L5-S1 intervertebral disc and no appar

215 At the leading edge of migrating cells, protrusion of the lamellipodium is driven by Arp2/3-medi

216 Advancing protrusions of gliding cells push, on average, in the di

217 and RNA-Seq, we find that RNAs localized in protrusions of migrating fibroblasts can be distinguishe

218 Stromules are highly dynamic protrusions of the plastids in plants.

219 We found that, like leukocytes, surface protrusion on an EC did exist when a point force was imp

220 that of residual intrastent plaque/thrombus protrusion) on outcome.

221 ongation of filament barbed ends in membrane protrusions or at the surface of bacterial pathogens.

222 The bilayers either expel lipid protrusions or spread laterally as a result of the ensui

223 in the surface ectoderm, we show that these protrusions originate from surface ectodermal cells and

224 rowth period, the primary M7C3 carbide forms protrusion parallel to {} crystal planes.

225 ind that the structured ECM orients cellular protrusions parallel to the ECM.

226 , forming networks involved in lamellipodial protrusion, phagocytosis, and cell adhesion.

227 The co-alignment of multiple protrusions polarizes the entire cell; if the fibers are

228 al role and molecular regulation of membrane protrusions prior to fusion of a key organ primordium in

229 nt after modified-T, whereas in 3 of 5 T-and protrusion procedures single strut fractures were noted.

230 gakaryocytes (MKs), which extend cytoplasmic protrusions (proplatelets) into BM sinusoids.

231 ac1 evident at the leading edge, while small protrusions, rapid turnover of immature focal adhesions

232 This spatial organization of protrusion relies on myosin II contractility, and feedba

233 icient control of actin polymerization-based protrusion requires an additional mechanosensory feedbac

234 ease Mpl is required for ActA processing and protrusion resolution.

235 Impaired formation of actin-based protrusions, resulting in slower three-dimensional migra

236 As membrane tension decreases, protrusion resumes and buckling disappears, until the ne

237 ab1 probe also allows us to control membrane protrusion, retraction and ruffling by local illuminatio

238 rrant rigidity sensing, loss of CUs, loss of protrusion-retraction cycles, and, surprisingly, enables

239 the leading edges of cells undergo periodic protrusion-retraction cycles.

240 Tongue protrusion-retraction is critical to early nutrition but

241 ion, spatiotemporal coordination of membrane protrusion/retraction, and how cells within each mode re

242 duced filopodia and associated abnormal cell protrusions seen in Pak2 (Delta/Delta)HSPCs were rescued

243 , -6, -7, and -9 accumulate at predetermined protrusion sites and form collar-like structures at the

244 Protrusion stability and persistence are functions of ad

245 not aligned, contact guidance of individual protrusions still occurs, but does not produce overall c

246 Jaw protrusion substantially enhances the suction feeding me

247 es in the extension of actin-filled membrane protrusions such as filopodia and bind to microtubules (

248 ructure regulators within stable actin-based protrusions such as stereocilia and calycal processes.

249 ve ovarian cancer cells spontaneously formed protrusions, such as lamellipodia, which are required fo

250 isoforms exhibit different types of membrane protrusions, such as multiple blebs, lamellipodia, combi

251 ed in a pocket located at the base of capsid protrusions surrounding icosahedral 3-fold axes.

252 is and surrounding the 5-fold symmetry axis, protrusions surrounding the 3-fold symmetry axis, and a

253 Abnormal nuclear morphology and protrusions termed "blebs" are diagnostic markers for ma

254 esearchers have been fascinated by the small protrusions, termed spines, studding many neuronal dendr

255 he exocyst and SNARE SNAP-29 to form a large protrusion that invades vulval tissue.

256 The primary cilium is a membrane protrusion that is crucial for vertebrate tissue homeost

257 n matrices and track the many small membrane protrusions that appear in these more physiologically re

258 rface fibers, but features 30 A-long surface protrusions that are formed by loops of the major capsid

259 Invadosomes are actin-rich membrane protrusions that degrade the extracellular matrix to dri

260 ovement likely depends on epidermal cellular protrusions that directly contact pObs only where an oth

261 Sema7A controls the assembly of actin-based protrusions that drive DC migration in response to CCL21

262 fuels generation of large, invasive cellular protrusions that expand tiny basement membrane openings.

263 ghly specialized small antenna-like cellular protrusions that extend from the cell surface of many eu

264 re solitary, generally non-motile, hair-like protrusions that extend from the surface of cells betwee

265 Invadopodia are actin-based protrusions that mediate the matrix degradation necessar

266 Blebs are pressure-driven protrusions that play an important role in cell migratio

267 ed motility and formation of plasma membrane protrusions that project into adjacent cells.

268 Invadopodia are specialized membrane protrusions that support degradation of extracellular ma

269 A within lamellipodia to couple actin-driven protrusion to adhesion and advance of the leading edge.

270 ansition of melanoma cells from actin-driven protrusion to blebbing, and we present tools to quantify

271 nascent integrin adhesions (NAs) within the protrusion to drive leading edge advance.

272 on fiber orientation; however the ability of protrusions to form closely spaced adhesions sequentiall

273 unattached cells make active plasma membrane protrusions to migrate.

274 s local retraction and, unexpectedly, distal protrusions to steer cells away.

275 acquired an asymmetric distribution of basal protrusions, traction forces, and apical aspect ratios t

276 The recent discovery of cellular protrusions - tumor microtubes - connecting cancer cells

277 ralong (>10 to hundreds of microns) membrane protrusions [tumor microtubes (TMs)] extended by glioma

278 tors, such as ENA/VASP proteins, to sites of protrusion underlies diverse molecular mechanisms of fil

279 The relative size of the putative genital protrusion varied more than 3-fold between species rangi

280 antagonistic Rac-Rho signaling, Rac-mediated protrusion (via activation of Arp2/3 actin nucleation) a

281 C-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance

282 We show that protrusion waves are due to fluctuations in actin polyme

283 sults, we developed a mathematical model for protrusion waves in which local depletion of VASP from t

284 ck from the cell membrane-results in regular protrusion waves.

285 Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length

286 mote actin polymerization and drive membrane protrusion, we find that Mena11a decreases actin polymer

287 ffness and the crossover force of EC surface protrusion were dependent on the force loading rate and

288 Macrophage filopodia, finger-like membrane protrusions, were first implicated in phagocytosis more

289 PS with additional T-and protrusion whenever needed seems a reasonable approach.

290 regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) a

291 nals in both IVa and IVb contained dendritic protrusions, whereas pulvinocortical terminals do not co

292 pathway and generate filopodial actin-spike protrusions which drive invasion.

293 embrane diffusion barrier at the neck of the protrusion, which enables protrusion growth.

294 nce is determined at the level of individual protrusions, which are individually guided by local fibe

295 llagen matrix using prominent, curved planar protrusions, which are rapidly remodeled and reoriented,

296 ng in thinner dendrites, excessive dendritic protrusion with loss of planarity, reduced resurgent sod

297 In this study, we examined EC surface protrusion with the micropipette aspiration technique.

298 Membrane nanotubes are cytosolic protrusions with diameters <1 microm that extend between

299 s of their stereocilia, which are actin-rich protrusions with graded heights that mediate mechanotran

300 ptic tectum extend highly dynamic filopodial protrusions within the tectal neuropil, the motility of