ライフサイエンスコーパス: protrusive

1 within the organoid body were isotropically protrusive.

2 ically depends on the formation of a ring of protrusive actin beneath the plasma membrane, which deve

3 They have a protrusive actin core and an adhesive ring of integrins

4 Structurally, podosomes consist of a protrusive actin core surrounded by adhesion proteins.

5 the formation of adhesive, contractile, and protrusive actin-based structures in spreading and migra

6 directing the cell movement, by coordinating protrusive activities and stabilizing the cell polarity.

7 ly members (p190(RhoGAP); p190) and membrane-protrusive activities at invadopodia.

8 orrelated with a lack of coordination of the protrusive activities at the leading edge of ARPC3(-/-)

9 ctive migration, and modulated spreading and protrusive activities of anterior mesendodermal cells.

10 ated by differential cell-cell adhesions and protrusive activities to drive proper vascular organizat

11 he localized matrix degradation and membrane-protrusive activities were blocked by treatment of LOX c

12 edge bear no apparent relationship to local protrusive activities.

13 showed Cx43alpha1KO CNCs have increased cell protrusive activity accompanied by the loss of polarized

14 DCX/actin filament patches exhibit vigorous protrusive activity and also undergo a proximal-to-dista

15 Profilin-2 and EVL suppress protrusive activity and cell motility by an actomyosin c

16 hanced WRC formation, resulting in increased protrusive activity and cell motility.

17 The inhibition of protrusive activity and cell polarity disables confineme

18 These differences in protrusive activity and cell shape changes between the n

19 t with the basement membrane, exhibit biased protrusive activity and directed movement along the axis

20 in, result in significantly reduced cellular protrusive activity and invasive behavior.

21 ur analyses reveal that PGE(2) promotes cell protrusive activity and limits cell adhesion by modulati

22 This coupling between protrusive activity and matrix degradation facilitates t

23 cs of these three systems, Paks regulate the protrusive activity and migration of epithelial cells.

24 around the cell surface and promoted random protrusive activity and migration.

25 ence specifically by regulating the onset of protrusive activity and not the onset of integrin activa

26 hibit blebs and promote polarized actin-rich protrusive activity and PCP.

27 ells within these explants display monopolar protrusive activity and radially intercalate during expl

28 dhesion receptor is associated with enhanced protrusive activity and regulation of directional cell m

29 ding cells where it participates in membrane protrusive activity and the conversion of nascent adhesi

30 's forward movement reduced coupling between protrusive activity and translocation of the cell body:

31 el of how endothelial tip cells regulate its protrusive activity and will pave the way toward strateg

32 lization, paxillin trafficking, and cellular protrusive activity are regulated.

33 nized F-actin and display reduced filopodial protrusive activity at their leading edge.

34 is led by a quartet of cells, which exhibit protrusive activity at their medial tips and are require

35 t embryos maintain tissue polarity and basal protrusive activity but are deficient in apical neighbor

36 down, central growth cones display extensive protrusive activity but make little forward advance.

37 olarized cytoskeleton, loss of the polarized protrusive activity characteristic of intercalating cell

38 Border protrusive activity drives epithelization despite the pr

39 documents for the first time the dynamics of protrusive activity during epithelial cell rearrangement

40 first high-resolution video documentation of protrusive activity during neural convergent extension i

41 gree of phenotypic plasticity, and increased protrusive activity emerge as vital facilitators of rapi

42 Polarized PI3K activity influences protrusive activity from the epidermal leading edge and

43 d the WAVE complex creates stable regions of protrusive activity in each cell and aligns the cells' p

44 f myosin II activity has opposing effects on protrusive activity in fibroblasts on normal and fibroti

45 d to an increase in actin polymerization and protrusive activity in fibroblasts.

46 cells because the neural cells' mediolateral protrusive activity is episodic, whereas the protrusive

47 a(2), but not Ca(2+) signaling, and membrane protrusive activity is promoted by G proteins that deple

48 cell perimeter and fluctuates over time, and protrusive activity is reduced and unpolarized.

49 cross the growth cone is retained, as though protrusive activity is regulated to some set point.

50 Whether protrusive activity is required to maintain adhesion in

51 Actin polymerization-dependent protrusive activity is required to push distally separat

52 axial mesodermal cells fail to shut down the protrusive activity mediated by the Rho/ROCK/Myosin II p

53 d to induce the monopolar, medially directed protrusive activity of deep neural cells.

54 ich promotes neuritogenesis by balancing the protrusive activity of lamellipodia and filopodia.

55 of LASP1 is dynamically associated with the protrusive activity of lamellipodia, depends on the barb

56 protrusive activity is episodic, whereas the protrusive activity of mesodermal cells is more continuo

57 h synergizes with Cdc42 to contribute to the protrusive activity of migrating cells.

58 This work uncovers a stereotyped protrusive activity of newborn neurons that organize lon

59 ts that polarized trafficking stabilizes the protrusive activity of the cell, while protrusive activi

60 Therefore, actin polymerization-dependent protrusive activity operates continuously at cadherin ce

61 s the protrusive activity of the cell, while protrusive activity orients this polarity axis, leading

62 dge of these explants restores the monopolar protrusive activity over the entire extent of the midlin

63 Our results suggest an important role for protrusive activity resulting in cell displacement and f

64 ole for integrin signaling in regulating the protrusive activity that drives axial extension.

65 ed that Rac1 is essential for generating the protrusive activity that drives the collective migration

66 tered cytoarchitecture and enhanced membrane protrusive activity that was associated with circumferen

67 ton to constrain process number and restrict protrusive activity to a single leading process, thus re

68 Like regions of high curvature, protrusive activity travels along the boundary in a wave

69 bm(DeltaPDZ-B) fail to acquire the polarized protrusive activity underlying normal cell intercalation

70 rget sites with reduced Flt1 and/or elevated protrusive activity were more likely to form stable conn

71 ral deep cells exhibit mediolaterally biased protrusive activity which is expressed in an episodic fa

72 eceptor signaling regulates endothelial cell protrusive activity, a key determinant of blood vessel m

73 The dynamic properties and polarity of protrusive activity, along with lamellipodia formation,

74 ls of the myeloid lineage exhibited elevated protrusive activity, altered adhesion dynamics, impaired

75 profoundly alters cell morphology, enhances protrusive activity, and can increase the velocity but r

76 e primitive streak, the subsequent polarized protrusive activity, and CE and axial elongation all fai

77 in1-null DCs rescues the defects in membrane protrusive activity, as well as in podosome disassembly.

78 human HL-60 neutrophils, we abruptly altered protrusive activity, bypassing the chemoattractant recep

79 osomes that promote breast cancer cell (BCC) protrusive activity, motility, and metastasis by activat

80 d feedback between adhesion and Rac-mediated protrusive activity, such that we find Arp2/3 inhibition

81 al focal complexes and exhibit high membrane protrusive activity, while differentiated trophoblast gi

82 subsequent onset of mediolaterally polarized protrusive activity.

83 ngiogenesis, fail to extend and show reduced protrusive activity.

84 matrix remodeling spatially correlates with protrusive activity.

85 ized along the mediolateral axis and exhibit protrusive activity.

86 te cells show a monopolar, medially directed protrusive activity.

87 derm show a bipolar, mediolaterally directed protrusive activity.

88 dline, show bipolar, mediolaterally oriented protrusive activity.

89 required for the initiation of trophectoderm protrusive activity.

90 and nonmetastatic cells are motile and show protrusive activity.

91 lial cell response-a marked decrease in cell protrusive activity.

92 F gain of function strikingly increased cell protrusive activity.

93 tin in mesoderm migration is to control cell protrusive activity.

94 disorganized actin cytoskeleton and altered protrusive activity.

95 f coordination between matrix remodeling and protrusive activity.

96 ells, where their exocytosis correlates with protrusive activity.

97 ion of EGF receptors, cell aspect ratio, and protrusive activity.

98 es, indicating the subsequent onset of local protrusive activity.

99 orce of actin bundles is essential for their protrusive activity.

100 tes epithelial intercalation via basolateral protrusive activity.

101 ithelial intercalation relies on basolateral protrusive activity.

102 at this is associated with randomly directed protrusive activity.

103 dary rearrangement and polarized basolateral protrusive activity.

104 t cells, curvature waves are associated with protrusive activity.

105 null DCs exhibit severely decreased membrane protrusive activity.

106 plate/floor plate-specific randomly oriented protrusive activity; (3) the characteristic lack of mixi

107 Actin filament networks exert protrusive and attachment forces on membranes and thereb

108 l transition, revealing a successive loss of protrusive and circumferential tractions, as well as the

109 Eukaryotic cells have diverse protrusive and contractile actin filament structures, wh

110 propose a "compass" model according to which protrusive and contractile actomyosin networks self-pola

111 Coordination of protrusive and contractile cell-matrix contacts is impor

112 t ERK activity can coordinately amplify both protrusive and contractile forces for optimal cell motil

113 ganization depends on cytoskeleton-generated protrusive and contractile forces.

114 eton in invadopodia, thus promoting membrane-protrusive and degradative activities necessary for cell

115 We propose that the protrusive and resisting forces from fusion partners put

116 he accumulation of stress fibres and loss of protrusive and retractile activity.

117 ased on spatially heterogeneous contractile, protrusive, and circumferential tractions.

118 ace, and retracting from the other outwardly protrusive arm.

119 rs are coordinated to generate these diverse protrusive arrays.

120 3D cell cultures has been shown to influence protrusive behavior [2-5].

121 migration, but they fail to shut down their protrusive behavior and undergo the normal intercalation

122 etermined the effect of S100A4 expression on protrusive behavior during chemoattractant-stimulated mo

123 Protrusive behavior of dendritic spines on developing ne

124 entrioles and the accumulation of MTs on the protrusive behavior required during the initiation of ra

125 forces result in coordinate changes in cell protrusive behavior.

126 s both convergent extension and mediolateral protrusive behaviors in explant preparations.

127 how different tissues in vivo craft diverse protrusive behaviors using the same genomic toolkit of a

128 itherto unrecognised and partially redundant protrusive behaviours during later mesoderm spreading.

129 Contractile actomyosin and protrusive branched F-actin networks interact in a dynam

130 variety of cell behaviors such as polarized protrusive cell activity, directional cell movement, and

131 ascade may regulate actin polymerization and protrusive cell behavior in the caudal SpM to promote SH

132 RNA-based knockdown of muskelin resulted in protrusive cell morphologies with enlarged cell perimete

133 -FLI1 protein product causes a shift to more protrusive cells and decreased tissue specificity of the

134 ensity and architecture of its actin network.Protrusive cellular structures contain a heterogeneous d

135 nits of PKA and PKA activity are enriched in protrusive cellular structures formed during chemotaxis.

136 lial cells using lamellipodia as the initial protrusive contact, subsequently transforming into filop

137 The podosome protrusive core contains a central branched actin module

138 ctin assembly of the branched network at the protrusive cup edge, which is initiated by the actin-rel

139 cytoskeletal regulators such as WAVE1 to the protrusive edges where they are needed to elaborate proc

140 changeable associations with contractile and protrusive effectors, Sdk is central to controlling the

141 While the protrusive event of cell locomotion is thought to be dri

142 protein may also have roles in leading edge protrusive events.

143 te Rac activation with plasma membrane-based protrusive events.

144 tidylinositol 3,4,5-trisphosphate (PIP3) and protrusive F-actin at the front and actomyosin contracti

145 We infer that protrusive F-actin, induced by the frontness response, c

146 Invadopodia are protrusive, F-actin-driven membrane structures that are

147 ergent signals that promote the formation of protrusive filamentous actin (F-actin; frontness) and Rh

148 During spreading, a wave of protrusive force (75 +/- 8 pN/post) propagates radially

149 on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mech

150 ses in the mutual information between tongue-protrusive force and spiking activity, (3) reductions in

151 cin delivering the rigidity and strength for protrusive force and structural stability, whereas L-pla

152 contributions of nucleation and branching to protrusive force are still unknown.

153 We propose that MSP generates the protrusive force for its own vesicular export.

154 is required for nucleation in vitro and for protrusive force in vivo, it is not required for EGF-sti

155 itly verified by systematically reducing the protrusive force of the actin network in experiments usi

156 Based on the simple model where the protrusive force on the membrane is generated by the int

157 aments, which through polymerization exert a protrusive force on the membrane.

158 rt, branched actin filaments, generating the protrusive force that extends lamellipodia and drives fi

159 ex of mhcA- cells cannot generate sufficient protrusive force to break the contacts between adhered c

160 The magnitude of the protrusive force was found to be unchanged in response t

161 r pool, too few are insufficient to generate protrusive force, so motility is stalled at either extre

162 f cortex as monkeys learn to generate tongue-protrusive force.

163 +/- 37 nm/s) without significantly reducing protrusive force.

164 n force generation that follow rounding: (1) Protrusive forces along the division axis that drive div

165 size that leader cells need to generate high protrusive forces and overcome extracellular matrix (ECM

166 We find that Arp2/3-dependent protrusive forces and Rac1/Cdc42 activity were generally

167 tion of actin filament barbed ends generates protrusive forces at the cell edge, leading to cell migr

168 appears to regulate both cell adhesions and protrusive forces during NCC delamination.

169 process in many biology systems and involves protrusive forces generated by actin polymerization, myo

170 An alternative mechanism, based on the protrusive forces generated by microtubule elongation or

171 by curved membrane proteins that recruit the protrusive forces of actin polymerization, and identifie

172 We demonstrate that traction-mediated protrusive forces or contractile forces due to myosin II

173 polymerization at the leading edge generates protrusive forces that open a path for the monocytes to

174 es that are capable of producing coordinated protrusive forces without buckling is not well understoo

175 polarity with differential distributions of protrusive forces, cell-matrix adhesion, and myosin-base

176 Polarization of cells into a protrusive front and a retracting cell body is the hallm

177 vergent pathways that promote formation of a protrusive front and contracting back and sides.

178 of actin-driven protrusion encircling a non-protrusive interior domain.

179 l framework to couple matrix remodeling with protrusive invasion.

180 eading, fascin spike assembly, and extensive protrusive lateral ruffling on TSP-1 or on syndecan-1 an

181 cells must become polarized, establishing a protrusive leading edge and a contractile trailing edge.

182 Cells employ protrusive leading edges to navigate and promote their m

183 itatively the propulsion of Listeria and the protrusive mechanics of lamellipodia.

184 This is the first case in which the protrusive mechanism underlying epithelial cell rearrang

185 erization process for blocking intercellular protrusive membrane activity and for coupling AJs with t

186 nges in cell shape, notably the formation of protrusive membrane extensions.

187 localize to sites of actin polymerization in protrusive membrane structures and regulate actin dynami

188 purely filopodial, and that it extends by a protrusive mode of growth.

189 10A-Kras, HOXA5 loss increased branching and protrusive morphology in Matrigel, all features suggesti

190 Current models for protrusive motility in animal cells focus on cytoskeleto

191 ivation markedly (approximately 40%) reduced protrusive motility in deprived regions of the barrel co

192 s reveal a role for Rac2-mediated macrophage protrusive motility in melanoma invasion.

193 c or genetic inhibition of myosin IIB alters protrusive motility of spines, destabilizes their classi

194 pulations, we demonstrated that EVL promotes protrusive motility through membrane-direct actin polyme

195 a common dendritic nucleation mechanism for protrusive motility.

196 boundary shape thus reflects the history of protrusive motion.

197 on of novel hybrid KIR genes, facilitated by protrusive non-B DNA structures at transposon recombinat

198 ng in short-range connectivity and a focally protrusive, non-degradative state.

199 Inhibiting protrusive or contractile forces shifted this transition

200 tumor is mediated by invadopodia, actin-rich protrusive organelles that secrete matrix metalloproteas

201 omes that deliver lipids and cargoes to fuel protrusive outgrowth of nascent dendrites.

202 e plasma membrane, which became increasingly protrusive over time.

203 length, F-actin organization, lifetime, and protrusive persistence.

204 MP at tips of invadopodia as the duration of protrusive phase is increased, and (2) the movement of n

205 ntrol of PIP(3) by Pten and PI3K governs the protrusive phase of junctional remodeling, which is esse

206 t in Ikkbeta(-/-) cells caused a reversal of protrusive phenotype and high motility, respectively.

207 ac and inactive Rho followed by formation of protrusive processes mediated by active Cdc42 and inacti

208 ment of CECs with FGF-2 induced formation of protrusive processes through activated Cdc42.

209 Formation of protrusive processes was observed in the elongated cells

210 ltilayers of spindle-shaped cells containing protrusive processes, is mediated by fibroblast growth f

211 nd defined a quantitative "fingerprint"--the protrusive profile--which our data suggest is characteri

212 y as early as 30 s and remained localized to protrusive regions at later time points.

213 Localization of RNAs at protrusive regions of cells is important for single-cell

214 rst component to appear visibly organized in protrusive regions of the cell.

215 this, AMIC colocalizes with PIP2 at dynamic, protrusive regions of the plasma membrane.

216 y to the cell cortex and becomes enriched in protrusive regions, a localization pattern that is simil

217 tream of UNC-5, and a long isoform had a pro-protrusive role.

218 on requires both polarized activation of the protrusive signal, Rac1, and redistribution of inactive

219 ization coefficient, defined as the ratio of protrusive stress to tissue-substrate friction, that all

220 We identify an actin-based protrusive structure in growth cones termed "intrapodium

221 ght all control the formation of actin-based protrusive structures (lamellipodia and filopodia) that

222 n cytoskeleton within the tumor cell to form protrusive structures and (ii) vascular permeablization

223 convex plasma membrane areas at the base of protrusive structures and interacted with three motifs i

224 We propose that these protrusive structures enhance signaling by increasing co

225 Podosomes are protrusive structures implicated in macrophage extracell

226 Rac1 and Cdc42 stimulate the formation of protrusive structures such as membrane ruffles, lamellip

227 Invadopodia are protrusive structures used by tumor cells for degradatio

228 he AIF-induced, ARF6- dependent formation of protrusive structures was blocked by cytochalasin D and

229 Filopodia are finger-like protrusive structures, containing actin bundles.

230 tin-dependent events, including formation of protrusive structures, fibroblast migration, neurite ext

231 In protrusive structures, multiple actin filaments are arra

232 e plasma membrane at the leading edge of the protrusive structures, N-WASP is enriched with WIP along

233 Wnt-3a induced cell spreading, formation of protrusive structures, reorganization of stress fibers a

234 based motility does not appear to be through protrusive structures, such as lamellipodia or filopodia

235 ilament growth and the formation of numerous protrusive structures.

236 inocytosis and membrane recycling within the protrusive structures.

237 as well as protrusion-dominated spreading ("protrusive zipper hypothesis").

238 In contrast, the protrusive zipper model agrees well with experimental fi