ライフサイエンスコーパス: protrusive

1 within the organoid body were isotropically protrusive.

2 ically depends on the formation of a ring of protrusive actin beneath the plasma membrane, which deve

3 They have a protrusive actin core and an adhesive ring of integrins

4 the formation of adhesive, contractile, and protrusive actin-based structures in spreading and migra

5 directing the cell movement, by coordinating protrusive activities and stabilizing the cell polarity.

6 ly members (p190(RhoGAP); p190) and membrane-protrusive activities at invadopodia.

7 orrelated with a lack of coordination of the protrusive activities at the leading edge of ARPC3(-/-)

8 ctive migration, and modulated spreading and protrusive activities of anterior mesendodermal cells.

9 ated by differential cell-cell adhesions and protrusive activities to drive proper vascular organizat

10 he localized matrix degradation and membrane-protrusive activities were blocked by treatment of LOX c

11 edge bear no apparent relationship to local protrusive activities.

12 showed Cx43alpha1KO CNCs have increased cell protrusive activity accompanied by the loss of polarized

13 DCX/actin filament patches exhibit vigorous protrusive activity and also undergo a proximal-to-dista

14 Profilin-2 and EVL suppress protrusive activity and cell motility by an actomyosin c

15 The inhibition of protrusive activity and cell polarity disables confineme

16 These differences in protrusive activity and cell shape changes between the n

17 t with the basement membrane, exhibit biased protrusive activity and directed movement along the axis

18 in, result in significantly reduced cellular protrusive activity and invasive behavior.

19 ur analyses reveal that PGE(2) promotes cell protrusive activity and limits cell adhesion by modulati

20 cs of these three systems, Paks regulate the protrusive activity and migration of epithelial cells.

21 around the cell surface and promoted random protrusive activity and migration.

22 ence specifically by regulating the onset of protrusive activity and not the onset of integrin activa

23 ells within these explants display monopolar protrusive activity and radially intercalate during expl

24 dhesion receptor is associated with enhanced protrusive activity and regulation of directional cell m

25 's forward movement reduced coupling between protrusive activity and translocation of the cell body:

26 lization, paxillin trafficking, and cellular protrusive activity are regulated.

27 nized F-actin and display reduced filopodial protrusive activity at their leading edge.

28 is led by a quartet of cells, which exhibit protrusive activity at their medial tips and are require

29 t embryos maintain tissue polarity and basal protrusive activity but are deficient in apical neighbor

30 down, central growth cones display extensive protrusive activity but make little forward advance.

31 olarized cytoskeleton, loss of the polarized protrusive activity characteristic of intercalating cell

32 Border protrusive activity drives epithelization despite the pr

33 documents for the first time the dynamics of protrusive activity during epithelial cell rearrangement

34 first high-resolution video documentation of protrusive activity during neural convergent extension i

35 gree of phenotypic plasticity, and increased protrusive activity emerge as vital facilitators of rapi

36 Polarized PI3K activity influences protrusive activity from the epidermal leading edge and

37 f myosin II activity has opposing effects on protrusive activity in fibroblasts on normal and fibroti

38 cells because the neural cells' mediolateral protrusive activity is episodic, whereas the protrusive

39 cross the growth cone is retained, as though protrusive activity is regulated to some set point.

40 axial mesodermal cells fail to shut down the protrusive activity mediated by the Rho/ROCK/Myosin II p

41 d to induce the monopolar, medially directed protrusive activity of deep neural cells.

42 protrusive activity is episodic, whereas the protrusive activity of mesodermal cells is more continuo

43 h synergizes with Cdc42 to contribute to the protrusive activity of migrating cells.

44 dge of these explants restores the monopolar protrusive activity over the entire extent of the midlin

45 Our results suggest an important role for protrusive activity resulting in cell displacement and f

46 ole for integrin signaling in regulating the protrusive activity that drives axial extension.

47 ed that Rac1 is essential for generating the protrusive activity that drives the collective migration

48 tered cytoarchitecture and enhanced membrane protrusive activity that was associated with circumferen

49 ton to constrain process number and restrict protrusive activity to a single leading process, thus re

50 Like regions of high curvature, protrusive activity travels along the boundary in a wave

51 bm(DeltaPDZ-B) fail to acquire the polarized protrusive activity underlying normal cell intercalation

52 rget sites with reduced Flt1 and/or elevated protrusive activity were more likely to form stable conn

53 ral deep cells exhibit mediolaterally biased protrusive activity which is expressed in an episodic fa

54 eceptor signaling regulates endothelial cell protrusive activity, a key determinant of blood vessel m

55 The dynamic properties and polarity of protrusive activity, along with lamellipodia formation,

56 ls of the myeloid lineage exhibited elevated protrusive activity, altered adhesion dynamics, impaired

57 profoundly alters cell morphology, enhances protrusive activity, and can increase the velocity but r

58 e primitive streak, the subsequent polarized protrusive activity, and CE and axial elongation all fai

59 in1-null DCs rescues the defects in membrane protrusive activity, as well as in podosome disassembly.

60 osomes that promote breast cancer cell (BCC) protrusive activity, motility, and metastasis by activat

61 d feedback between adhesion and Rac-mediated protrusive activity, such that we find Arp2/3 inhibition

62 al focal complexes and exhibit high membrane protrusive activity, while differentiated trophoblast gi

63 ized along the mediolateral axis and exhibit protrusive activity.

64 es, indicating the subsequent onset of local protrusive activity.

65 orce of actin bundles is essential for their protrusive activity.

66 te cells show a monopolar, medially directed protrusive activity.

67 derm show a bipolar, mediolaterally directed protrusive activity.

68 dline, show bipolar, mediolaterally oriented protrusive activity.

69 required for the initiation of trophectoderm protrusive activity.

70 and nonmetastatic cells are motile and show protrusive activity.

71 lial cell response-a marked decrease in cell protrusive activity.

72 F gain of function strikingly increased cell protrusive activity.

73 tes epithelial intercalation via basolateral protrusive activity.

74 tin in mesoderm migration is to control cell protrusive activity.

75 ithelial intercalation relies on basolateral protrusive activity.

76 at this is associated with randomly directed protrusive activity.

77 dary rearrangement and polarized basolateral protrusive activity.

78 t cells, curvature waves are associated with protrusive activity.

79 null DCs exhibit severely decreased membrane protrusive activity.

80 ion of EGF receptors, cell aspect ratio, and protrusive activity.

81 subsequent onset of mediolaterally polarized protrusive activity.

82 ngiogenesis, fail to extend and show reduced protrusive activity.

83 matrix remodeling spatially correlates with protrusive activity.

84 plate/floor plate-specific randomly oriented protrusive activity; (3) the characteristic lack of mixi

85 Actin filament networks exert protrusive and attachment forces on membranes and thereb

86 propose a "compass" model according to which protrusive and contractile actomyosin networks self-pola

87 Coordination of protrusive and contractile cell-matrix contacts is impor

88 eton in invadopodia, thus promoting membrane-protrusive and degradative activities necessary for cell

89 We propose that the protrusive and resisting forces from fusion partners put

90 he accumulation of stress fibres and loss of protrusive and retractile activity.

91 ace, and retracting from the other outwardly protrusive arm.

92 rs are coordinated to generate these diverse protrusive arrays.

93 migration, but they fail to shut down their protrusive behavior and undergo the normal intercalation

94 etermined the effect of S100A4 expression on protrusive behavior during chemoattractant-stimulated mo

95 Protrusive behavior of dendritic spines on developing ne

96 forces result in coordinate changes in cell protrusive behavior.

97 s both convergent extension and mediolateral protrusive behaviors in explant preparations.

98 how different tissues in vivo craft diverse protrusive behaviors using the same genomic toolkit of a

99 itherto unrecognised and partially redundant protrusive behaviours during later mesoderm spreading.

100 variety of cell behaviors such as polarized protrusive cell activity, directional cell movement, and

101 ascade may regulate actin polymerization and protrusive cell behavior in the caudal SpM to promote SH

102 RNA-based knockdown of muskelin resulted in protrusive cell morphologies with enlarged cell perimete

103 ensity and architecture of its actin network.Protrusive cellular structures contain a heterogeneous d

104 nits of PKA and PKA activity are enriched in protrusive cellular structures formed during chemotaxis.

105 lial cells using lamellipodia as the initial protrusive contact, subsequently transforming into filop

106 cytoskeletal regulators such as WAVE1 to the protrusive edges where they are needed to elaborate proc

107 While the protrusive event of cell locomotion is thought to be dri

108 protein may also have roles in leading edge protrusive events.

109 te Rac activation with plasma membrane-based protrusive events.

110 tidylinositol 3,4,5-trisphosphate (PIP3) and protrusive F-actin at the front and actomyosin contracti

111 We infer that protrusive F-actin, induced by the frontness response, c

112 Invadopodia are protrusive, F-actin-driven membrane structures that are

113 ergent signals that promote the formation of protrusive filamentous actin (F-actin; frontness) and Rh

114 During spreading, a wave of protrusive force (75 +/- 8 pN/post) propagates radially

115 ses in the mutual information between tongue-protrusive force and spiking activity, (3) reductions in

116 cin delivering the rigidity and strength for protrusive force and structural stability, whereas L-pla

117 contributions of nucleation and branching to protrusive force are still unknown.

118 We propose that MSP generates the protrusive force for its own vesicular export.

119 is required for nucleation in vitro and for protrusive force in vivo, it is not required for EGF-sti

120 Based on the simple model where the protrusive force on the membrane is generated by the int

121 aments, which through polymerization exert a protrusive force on the membrane.

122 rt, branched actin filaments, generating the protrusive force that extends lamellipodia and drives fi

123 ex of mhcA- cells cannot generate sufficient protrusive force to break the contacts between adhered c

124 The magnitude of the protrusive force was found to be unchanged in response t

125 r pool, too few are insufficient to generate protrusive force, so motility is stalled at either extre

126 +/- 37 nm/s) without significantly reducing protrusive force.

127 f cortex as monkeys learn to generate tongue-protrusive force.

128 We find that Arp2/3-dependent protrusive forces and Rac1/Cdc42 activity were generally

129 tion of actin filament barbed ends generates protrusive forces at the cell edge, leading to cell migr

130 appears to regulate both cell adhesions and protrusive forces during NCC delamination.

131 process in many biology systems and involves protrusive forces generated by actin polymerization, myo

132 An alternative mechanism, based on the protrusive forces generated by microtubule elongation or

133 We demonstrate that traction-mediated protrusive forces or contractile forces due to myosin II

134 es that are capable of producing coordinated protrusive forces without buckling is not well understoo

135 Polarization of cells into a protrusive front and a retracting cell body is the hallm

136 vergent pathways that promote formation of a protrusive front and contracting back and sides.

137 l framework to couple matrix remodeling with protrusive invasion.

138 eading, fascin spike assembly, and extensive protrusive lateral ruffling on TSP-1 or on syndecan-1 an

139 Cells employ protrusive leading edges to navigate and promote their m

140 itatively the propulsion of Listeria and the protrusive mechanics of lamellipodia.

141 This is the first case in which the protrusive mechanism underlying epithelial cell rearrang

142 nges in cell shape, notably the formation of protrusive membrane extensions.

143 localize to sites of actin polymerization in protrusive membrane structures and regulate actin dynami

144 10A-Kras, HOXA5 loss increased branching and protrusive morphology in Matrigel, all features suggesti

145 Current models for protrusive motility in animal cells focus on cytoskeleto

146 ivation markedly (approximately 40%) reduced protrusive motility in deprived regions of the barrel co

147 c or genetic inhibition of myosin IIB alters protrusive motility of spines, destabilizes their classi

148 a common dendritic nucleation mechanism for protrusive motility.

149 boundary shape thus reflects the history of protrusive motion.

150 on of novel hybrid KIR genes, facilitated by protrusive non-B DNA structures at transposon recombinat

151 e plasma membrane, which became increasingly protrusive over time.

152 length, F-actin organization, lifetime, and protrusive persistence.

153 t in Ikkbeta(-/-) cells caused a reversal of protrusive phenotype and high motility, respectively.

154 ac and inactive Rho followed by formation of protrusive processes mediated by active Cdc42 and inacti

155 ment of CECs with FGF-2 induced formation of protrusive processes through activated Cdc42.

156 Formation of protrusive processes was observed in the elongated cells

157 ltilayers of spindle-shaped cells containing protrusive processes, is mediated by fibroblast growth f

158 nd defined a quantitative "fingerprint"--the protrusive profile--which our data suggest is characteri

159 y as early as 30 s and remained localized to protrusive regions at later time points.

160 rst component to appear visibly organized in protrusive regions of the cell.

161 this, AMIC colocalizes with PIP2 at dynamic, protrusive regions of the plasma membrane.

162 y to the cell cortex and becomes enriched in protrusive regions, a localization pattern that is simil

163 on requires both polarized activation of the protrusive signal, Rac1, and redistribution of inactive

164 ization coefficient, defined as the ratio of protrusive stress to tissue-substrate friction, that all

165 We identify an actin-based protrusive structure in growth cones termed "intrapodium

166 ght all control the formation of actin-based protrusive structures (lamellipodia and filopodia) that

167 n cytoskeleton within the tumor cell to form protrusive structures and (ii) vascular permeablization

168 We propose that these protrusive structures enhance signaling by increasing co

169 Podosomes are protrusive structures implicated in macrophage extracell

170 Rac1 and Cdc42 stimulate the formation of protrusive structures such as membrane ruffles, lamellip

171 Invadopodia are protrusive structures used by tumor cells for degradatio

172 he AIF-induced, ARF6- dependent formation of protrusive structures was blocked by cytochalasin D and

173 Filopodia are finger-like protrusive structures, containing actin bundles.

174 tin-dependent events, including formation of protrusive structures, fibroblast migration, neurite ext

175 In protrusive structures, multiple actin filaments are arra

176 Wnt-3a induced cell spreading, formation of protrusive structures, reorganization of stress fibers a

177 based motility does not appear to be through protrusive structures, such as lamellipodia or filopodia

178 inocytosis and membrane recycling within the protrusive structures.

179 ilament growth and the formation of numerous protrusive structures.