ライフサイエンスコーパス: prove

1 mic transformation and survival has not been proved.

2 eitis, although its noninferiority cannot be proved.

3 autoimmune etiology is suspected but not yet proven.

4 on RT in LA-SCCHN and noninferiority was not proven.

5 reason their efficacy and safety are rarely proven.

6 Images of beads prove a near-isotropic lateral resolution of sub-100 nm.

7 but-because of low patient numbers-would not prove a positive dose-response relationship.

8 Our in vitro cell model could prove a powerful tool to further dissect the complex pat

9 Overall, our findings have proved a major step forward to accurately modeling multi

10 estimation of age using methylation data has proved a useful and heritable biomarker, with accelerati

11 ween Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosp

12 ive for spheres and negative for saddles-has proven a versatile tool to guide the self-assembly of de

13 senting with symptomatic and sonographically proven acute isolated calf DVT.

14 Cumulative rates of biopsy-proven acute rejection (BPAR) from first randomization t

15 and conventional imaging modalities have not proved adequate.

16 ctively, the use of MS-based proteomics will prove advantageous for advancing the application of CFPS

17 Such information may prove advantageous in elucidating chemical class and res

18 An extended integrative view also proves advantageous in terms of conceptual coherence.

19 materials in flexible polymer materials has proven an effective way to achieve flexibility of functi

20 often because of difficulties in objectively proving an effective antireflux barrier.

21 Proven and cost-effective interventions are available fo

22 of the fatty acid quantification models was proven and the best classification of olive oils accordi

23 ppendicitis by utilizing histopathologically proven appendicitis and 6-week clinical follow-up as dia

24 VSVDeltaG pseudovirion vaccines may prove as efficacious and have better safety, but they ha

25 Few clades of plants have proven as difficult to classify as cacti.

26 this protease-dependent cleavage of Akt may prove beneficial in preventing tau hyperphosphorylation

27 of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound heal

28 icting the conditions under which Ca(2+) may prove beneficial.

29 Treatment of subclinical rejections has only proven beneficial to histological and functional outcome

30 This technique proves beneficial in reducing the amount of ink used dur

31 However, ELA proved better than Apelin-13 by improving fluid homeosta

32 For the beam tuner application, we prove both theoretically and experimentally that the dou

33 genes accounting for non-syndromic cases may prove broadly relevant to understanding other congenital

34 o)halide functionalities in the polymers was proved by elemental analysis, IR, and NMR spectroscopy.

35 Its identity with the natural isolate was proved by the comparison of the NMR and circular dichroi

36 The versatility of the approach has been proven by successful implementation in three case studie

37 presence of multiple GMOs was unambiguously proven by the characterization of transgene flanking reg

38 clinical trial open to patients with biopsy-proven carcinoma of the esophagus.

39 On the basis of proven cardiovascular and renal benefit, the antihypergl

40 in defined post-Golgi trafficking processes proved causal for this phenotype and might be due to lac

41 xperimental identification of these gaps has proved challenging.

42 at play a causal role in decision making has proved challenging.

43 have been reported in the literature, it has proven challenging to achieve high binding selectivity f

44 ed paradigm-chronic social defeat stress-has proven challenging to implement in females.

45 tanding the fine details of this synergy has proven challenging to scientific research.

46 nor templates for targeted gene addition has proven challenging, which in turn has limited the capabi

47 iscovery of selective, direct activators has proven challenging.

48 ring of absorbers having such properties has proven challenging.

49 t reproducibility in microbiome research has proven challenging.

50 al, 273 patients with possible, probable, or proven chronic Q fever were included.

51 All patients had HCV infection and biopsy-proven cirrhosis, were Child-Pugh class A, and had no pr

52 21 board-certified dermatologists on biopsy-proven clinical images with two critical binary classifi

53 logic phenomenon of reactive hyperoxia could prove clinically beneficial for both diagnosis and optim

54 r practical appropriateness has not yet been proven clinically.

55 As ClusterTAD is based on a proven clustering approach, it opens a new avenue to app

56 tion of criteria to screen for HSV test need proved cost-effective when less than 1 in 200 patients d

57 Asparagine further proved crucial in glutamine-deprived ECs to restore prot

58 ded in 20th century paint tube formulations, proved decisive for the formation of zinc stearate-like

59 m complexity sample, the higher speed of HCD proved decisive.

60 However, isolation of an electrogenic strain proved difficult as transfer cultures failed to grow aft

61 idate the full-length structure of NEMO have proved difficult due to its apparent high conformational

62 ural transition, although these changes have proved difficult to characterize at a global scale.

63 e precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multip

64 as the associated magnetic excitations have proven difficult to access with conventional techniques.

65 of the neocortex in human evolution, it has proven difficult to ascertain whether this extent of pre

66 ionships at the root of the animal tree have proven difficult to resolve, with the current debate foc

67 rtant determinant of T cell efficacy, it has proven difficult to selectively induce T cells of high f

68 ts as prolonged excruciating pain, which has proven difficult to treat.

69 ms governing protein-ligand interactions has proven difficult, with determination of entropic contrib

70 ake by the liver in live model organisms has proven difficult.

71 e and determining its behavioral impact have proven difficult.

72 oducing paCOS with patterns of interest have proven difficult.

73 known chemical compounds-for other purposes-proved disappointing in tests against Ebola virus (EBOV)

74 ly reviewed for patients with pathologically proven ECD.

75 ongoing trials of anti-inflammatory therapy prove effective.

76 A few TMG agents proved effective at both stabilizing a range of membrane

77 s brain-penetrant MT-stabilizing agents have proven effective against tau-mediated neurodegeneration

78 on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-indu

79 t therapeutic CD40-CD40L blocking agents may prove efficacious not only in early and established RA,

80 research community, the only treatment with proven efficacy is early reperfusion of the occluded cor

81 ir state and inter-triplet interactions have proved elusive.

82 es for parcellating higher-order cortex have proven elusive.

83 y mediated by cellular immune responses, has proven elusive.

84 ate behavior with individual neural data has proven elusive; even when successful, neural forecasts h

85 1, 2014, and December 31, 2016, with biopsy-proven EMPD in whom HRCM was used to monitor treatment r

86 comparisons, efficacy of the CD38 bispecific proved equal or superior to streptavidin (SA)-biotin-bas

87 These loci prove essential to accurately modeling yeast growth in r

88 th other novel therapeutic modalities should prove even more effective.

89 +/- 21 nM in neuroblastoma SHSY5Y cells and proved even to efficiently block cancer stem cell growth

90 iting representations and processes without "proving" every component.

91 Hitherto, ancient frozen soils have proved excellent in preserving DNA molecules, and have t

92 erostructures at such extreme dimensions has proven exceptionally challenging.

93 magnetism through N-doping has not yet been proved experimentally, except for systems containing a h

94 ealing these correlations experimentally has proved extremely challenging.

95 ing lestaurtinib with intensive chemotherapy proved feasible in younger patients with newly diagnosed

96 ments of a ferroelectric hysteresis loop, to prove ferroelectricity's hallmark switchable polarizatio

97 protein in glomeruli of patients with biopsy-proven focal segmental glomerulosclerosis (FSGS).

98 de polymorphisms (tag SNPs) in 367 challenge-proven food allergic cases, 199 food-sensitized tolerant

99 during early infancy to subsequent challenge-proven food allergy.

100 orption of sapotexanthin to human plasma was proven for the first time.

101 hensive NUDIX enzyme profile map, which will prove fundamental to understanding their biological func

102 st few years of life, for which there are no proven general therapies.

103 porting and Data System category 5 or biopsy-proven HCC and who were undergoing TAE were enrolled fro

104 , subsequent resection of a brain metastasis proved HER2-positive disease, confirming that the (89)Zr

105 only 34% to 60% of subjects with invasively proven HFpEF on the basis of resting echocardiographic d

106 ems, with dynamic network analyses likely to prove highly informative.

107 repertoire of Gag293-specific CD4(+) T cells proved highly biased, with a predominant usage of the TC

108 This method has proven highly useful to monitor the Warburg effect in ca

109 masses assessed at diagnostic US with biopsy-proven histologic findings and BI-RADS 3 masses stable a

110 t a GWAS comparing 73 infants with challenge-proven IgE-mediated peanut allergy against 148 non-aller

111 This phenomenon may prove important for the proper development and functioni

112 etabolites pimeloyl-CoA and glutaryl-CoA was proved in cell free extracts, yielding 2,3-dehydropimelo

113 Disease control has been proven in the metastatic and, to a limited extent, the a

114 This study proposes and proves (in concept) a novel approach of combining electr

115 Patients with a proven indication for a PPI should continue to receive i

116 table cardioverter defibrillator is the only proven lifesaving therapy; however, it is associated wit

117 d June 2015, 25 patients with histologically proved locally advanced pancreatic cancer 5 cm or smalle

118 In particular, the domestic pig is a proven model of human physiology and an agriculturally i

119 l to investigate early pathogenic events and prove molecular concepts in patients with psoriasis.

120 hymal GSCs, combined EZH2 and BMI1 targeting proved more effective than either agent alone both in cu

121 with the different approaches, overall qPCR proved more sensitive than qLAMP.

122 Among 237 patients with initial biopsy-proved N1 disease, 69 of 77 (89.6%) with and 68 of 160 (

123 erum metabolomes of 535 patients with biopsy-proven NAFLD (353 with simple steatosis and 182 with NAS

124 characterized cohort of patients with biopsy-proven NAFLD, this study demonstrates that hepatic scar

125 at the development of new antibiotics around proven natural scaffolds is the best short-term solution

126 in four leptomeningeal metastatic models and proved necessary for cancer growth within the leptomenin

127 ed guidelines, with emphasis on titration of proven neurohormonal therapies for HF.

128 ption of personhood, and science can neither prove nor refute the teaching of those religions that co

129 t influence, whereas an SUV threshold of 2.5 proved optimal for automated lesion quantification.

130 h was collected for for 244 individuals (132 proven or obligate C9orf72 carriers), of whom 147 were c

131 s), of whom 147 were clinically affected (89 proven or obligate C9orf72 carriers).

132 waiting surgical resection of histologically proven or radiologically suspected non-small cell lung c

133 All PCR-proven P. malariae monoinfections in Israeli travelers b

134 e sections from 25 patients with genetically-proven pathogenic CI variants.

135 y genetic variants associated with challenge-proven peanut allergy.

136 ifications of an existing and experimentally proven phononic crystal design, the snowflake crystal.

137 structure-function-toxicity relationship may prove pivotal for the detection and mitigation of amyloi

138 Patients with biopsy-proven PMN and nephrotic syndrome after 6 months of noni

139 Among 361 (8%) patients with culture-proven pneumococcal disease, all clinical data were know

140 suspected GBS during the outbreak, 30 had a proven presence of GBS, and 23 had a recent ZIKV infecti

141 T recipients and their donor pairs: 483 with proven/probable IA (183 SGM+) and 2126 with no IA by sta

142 ble LRTI (12 of 45 [27%]) than in those with proven/probable LRTI (29 of 42 [69%]).

143 ns and positive feedback mechanisms that can prove problematic for traditional probe positioning meth

144 cific modification of natural antibodies has proven quite challenging.

145 Antifolates have a proven record as clinically used oncolytic agents.

146 an age, 71.9 years +/- 10.9) with 217 biopsy-proven renal cell carcinoma tumors treated with thermal

147 aged 18 years and older with histologically proven, resectable oesophagogastric adenocarcinoma from

148 In summary, our technology was proven robust to obtain ground-based high-throughput pla

149 Gut microbiota has a proven role in regulating multiple neuro-chemical pathwa

150 structural-1 (NS1) protein from a clinically proven safe, Modified Vaccinia Ankara (MVA) vector, thus

151 responses within directly treated tumors and proved safer and more effective than combination therapy

152 uction of tumor-specific TCR genes, and that proved safer and more effective than conventional TCR ge

153 The proven secretion and surface exposure of mCherry suggest

154 optical simplicity of virtual-electrodes may prove significant for the future development of reconfig

155 ged 60 years and older with angiographically proven stable ischaemic heart disease or stage 2 Global

156 Antivascular therapy represents a proven strategy to treat angiogenesis.

157 Toxicity tests proved strong enantiomer-specific toxicity in the case o

158 Uterus transplantation has proven successful when performed with a living donor.

159 ived contact information for the subfamilies proves sufficient to assemble accurate structural models

160 The technology proved sufficiently sensitive that the same distinctive

161 few cell wall phenotyping methodologies have proven sufficiently precise, robust, or scalable for ass

162 ogous reaction using aldehyde substrates has proven surprisingly elusive.

163 onsecutive series of 55 patients with biopsy-proven SUSCC without bone invasion treated by wide surgi

164 nfirmed by significant downregulation of its proven targets, namely cyclin-dependent kinase 6 and Mcl

165 It has however proven technically challenging to study this parameter d

166 nitride stress capping layer is an industry proven technique for increasing electron mobility and dr

167 Here, we prove that a class of hierarchical architectures and a b

168 degron motif and exploit this information to prove that disruption of the FBXW7-DISC1 complex results

169 angling the quantum kinetic complexities, we prove that fcc lithium is the ground state, and we synth

170 Closer investigations could prove that l-pyroglutamic acid was able to influence non

171 Collectively, our results clearly prove that modulation of the microbiota induces positive

172 We prove that nodes are a consequence of the orthorhombic c

173 To prove that nuclear RNAi occurs and modulates transcripti

174 To prove that suspect products are non-authentic ideally re

175 Experimental and computational data now prove that the alkyne primarily acts as a four-electron

176 Importantly, we used mutagenesis to prove that the inhibition of TRAIL-induced apoptosis by

177 eosomes are components of these filaments to prove that they are SIR-nucleosome filaments.

178 A central tool to prove that viral PtDd neutralize HD5 and support spread

179 We prove that, modulo certain conjectures, the category of

180 We proved that it was directly targeted by miR-124-3p with

181 Recent experiments exploring this phenomenon proved that light-induced electron transfer can be stron

182 Likewise, we proved that our systems did not suffer from interference

183 esults validated the ping-pong mechanism and proved that Rb(+) deocclusion is accelerated when Na(+)

184 In vitro assays proved that recombinant VHR directly dephosphorylated FA

185 It was proved that the amount of urethanes generated at high te

186 Experiments performed to date have proven that real numbers are insufficient, but the need

187 This study proves that after interaction of cells with (f)Si NP, im

188 Our study proves that despite the overall decrease in FL concentra

189 Image analysis proves that the arabinoxylan surrounds the proteins, neg

190 tituted the ternary Mps2-Bbp1-Spc29 complex, proving that Bbp1 can simultaneously interact with Mps2

191 for cytokine production by immune cells and prove the applicability of FRET-FLIM for visualizing SNA

192 To prove the concept, we employed free energy perturbation

193 These results prove the contribution of high densities of CD11d to mac

194 proof-of-concept study has not been done to prove the principle that the Vgamma2Vdelta2 T cell subse

195 the obtained electrochemical results clearly proved the formation of H2O2 in the leaves of plants 3h

196 truments with several collision energies, we proved the method's platform independence.

197 e establish the feasibility of statistically proving the connection between binary black hole mergers

198 iques exhibited comparable performance, thus proving the prototyping ability of FDM versus IM.

199 toxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics.

200 terials above 2000 degrees C is necessary to prove their capabilities at anticipated operating temper

201 cause they could not meet the requirement of proving their forefathers settled in Burma before 1823,

202 ical edge solitons emerge undistorted, which proves them to be true solitons as opposed to solitary w

203 To prove this concept, trans-/intramucosal and lymph-node d

204 Despite numerous works that prove this phenomenon, a method to appropriately transla

205 We prove this principle using caffeine as a substrate in vi

206 e CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detai

207 ned source, and oral anticoagulant drugs may prove to reduce stroke risk from atrial cardiomyopathy g

208 , permitting NPC-mediated matrix remodelling proved to be a generalizable strategy for stemness maint

209 epression, however, its complex etiology has proved to be a major bottleneck in the identification of

210 The method under investigation proved to be a promising alternative to controlling cont

211 imer, guided by the knob-into-hole assembly, proved to be a stable conformation with homogeneous dist

212 Hilpda proved to be a target of hypoxia-inducible factor 1 (Hif

213 The use of a worst-rank analytical approach proved to be an important limitation of this study since

214 These variants proved to be classifiable by their likely biological act

215 The observed impairments proved to be decisive in vivo because silencing of the I

216 The clean-up step which employed chitosan proved to be effective, since it reduced both the matrix

217 possess favorable solubility properties has proved to be especially challenging.

218 ntaminated equipment, vehicles, or personnel proved to be important for several livestock epidemics.

219 tified as likely having roles in attenuation proved to be important for virulence.

220 cal outcomes, and deletion of data that have proved to be less relevant or difficult to capture.

221 Reproducing drying rates proved to be more challenging, but improved if the addit

222 bidirectional connections between IP and MnR proved to be primarily GABAergic.

223 roteins such as TAL effectors, has generally proved to be quite challenging.

224 f these overlaps at the onset of cytokinesis proved to be required to spatially confine membrane accu

225 PEEK SPME-TM devices proved to be robust and were therefore used to perform e

226 Endovascular management of SMAA proved to be safe and efficient.

227 VIT proved to be safe and no fatalities were recorded in the

228 coated with chitosan enriched with PPE (CHE) proved to be the most effective treatment in maintaining

229 methods for comparing protein sequences have proved to be viable alternatives to approaches that firs

230 Such alkenes are also proved to exhibit very clean on/off fluorescence switchi

231 tracts prepared from 'Bravo de Esmolfe' also proved to have antioxidant activity and antibacterial ef

232 These samples proved to have higher content of protein, polyunsaturate

233 No strategies have been proved to improve access to surgery for black patients w

234 The immobilized SrtA was proved to retain full enzymatic activity for peptide-to-

235 et sequence in the microRNA/target model has proven to be a more efficient strategy, accomplishing th

236 aphy tandem mass spectrometry (LC-MS/MS) has proven to be a powerful analytical tool for the characte

237 Second-order nonlinear spectroscopy has proven to be a powerful tool in elucidating key chemical

238 The Vmh2-GFP fusion protein has proven to be a smart and effective tool for the study of

239 Fat grafting has proven to be a useful adjunct to breast reconstruction f

240 evels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advant

241 Three-dimensional (3D) printing has proven to be a versatile and useful technology for speci

242 cs, as the underlying mathematical tool, has proven to be a versatile approach to achieve such unusua

243 Thus, ptxD/Phi has proven to be a very efficient, positive selection system

244 The marine environment has proven to be a very rich source of diverse natural produ

245 Recently, ABA has been proven to be also secreted and active in mammals, where

246 rbation of the protein-protein interface has proven to be an efficient strategy to inactivate TNFalph

247 s can be produced in polynomial time and are proven to be asymptotically bounded by a theoretical opt

248 inical tolerance in autoimmune diseases have proven to be challenging.

249 nt of an effective vaccine against HIV-1 has proven to be challenging.

250 om temperature under mild conditions and has proven to be compatible with a variety of electron-donat

251 o vary considerably between systems and have proven to be difficult to predict, spurring the need for

252 core with three boron atoms, and these have proven to be effective catalysts for a number of reactio

253 ber of mono- and bidentate ligands have also proven to be effective for accelerating C(sp(3))-H activ

254 decades, cyclophosphamide treatment has been proven to be effective in patients with antibody-associa

255 CIL has been proven to be essential for NC migration in amphibians an

256 d, mathematically supported, methodology was proven to be highly appropriate and satisfactory for cap

257 This methodology has proven to be highly effective in delivering miRNA molecu

258 Although transcriptional regulation has proven to be important for keratinocyte differentiation,

259 r-associated genes between regions that were proven to be normal via histopathologic analysis (34 mut

260 The method is proven to be robust with high-yield (>98%) over large ar

261 Thus far, it has proven to be safe and immunogenic, but it is expected th

262 Ion mobility spectrometry (IMS) has proven to be useful in separating isomer and isobar ions

263 ectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain

264 Enoldiazo esters and amides have proven to be versatile reagents for cycloaddition reacti

265 dissociation (UVPD) using 193 nm photons has proven to be well-suited for activation and fragmentatio

266 UPS-indel is theoretically proven to find all equivalent indels, and thus exhaustiv

267 hysiological technique is available that has proven to have good classification performance, and the

268 lectronic and magnetic behaviours, have been proven to play a crucial role in photovoltaic properties

269 ApN proves to be a powerful protector of the skeletal muscle

270 Our robust method proves to be a promising alternative for the high-throug

271 vity of the immune system against tumors are proving to be an effective therapeutic approach in multi

272 Phosphodiesterases are proving to be fruitful targets for drug discovery.

273 There are no proven treatments.

274 mperature vapor phase epitaxy (VPE) has been proved ubiquitously powerful in enabling high-performanc

275 le complexes, including dynamic regions that proved unresolvable by X-ray crystallography in homologo

276 n genetic variants are therefore unlikely to prove useful as predictive biomarkers of ICS response in

277 This method may also prove useful for imaging other structures, such as neuro

278 This demonstrates that this strategy might prove useful for next generation sequencing.

279 This model will prove useful for preclinical drug studies and for elucid

280 Our findings could prove useful for quantum gate operations, but also for c

281 t for targeting these retinopathies may also prove useful for the treatment of many forms of RP.

282 he bone marrow, this MSC subpopulation could prove useful in determining the risk of metastatic disea

283 We anticipate that GWAX will prove useful in future genetic studies of complex traits

284 e genetic diversity of gametes, which should prove useful in plant breeding and other applications.

285 e discovery of novel biomarkers may not only prove useful in predicting severity of illness but also

286 and aggressiveness, the pHLIP technology may prove useful in targeting cancer cells and metastases fo

287 these materials.Carbon-based molecules could prove useful in terahertz and optical devices controlled

288 Furthermore, voltage-ramp stimulation proved useful.

289 duced fragmentation of analytes, ME-SIMS has proven useful for detection of numerous biorelevant spec

290 These detailed data have been proven useful for inferring disease transmission to a mo

291 Multicellular monolayer cultures have proven useful for investigating arrhythmias and other co

292 We recommend techniques that have proven useful in each stage of the data analysis process

293 ts using early-onset glaucoma genes are also proving useful for pre-symptomatic disease detection and

294 Moreover, we prove using the relationship between the temperatures of

295 The prevalence of culture-proven UTI among pregnant women with UTI symptoms was 4%

296 e nuclease resistance and that SFM4-3 should prove valuable for the further exploration and productio

297 ifficult to study experimentally, but it has proven valuable to prepare and probe transition-state dy

298 organic self-assembled spheres along with GO proved very valuable for the detection of PPi in unprece

299 We prove with ISH that HRVs can enter B cells, form their v

300 be related to focal iron deposits; this was proven with Perls staining in two patients.