ライフサイエンスコーパス: prove to be

1 in quantification, yield and operating cost, proved to be: 40% ethanol:methanol during 40min, under 4

2 the high specificity of Cry toxins can also prove to be a limitation when there is no known Cry toxi

3 ted modulation of Rip2 and IRAK pathways may prove to be a novel treatment for sarcoidosis.

4 ention and designing antagonists to hPXR may prove to be a promising adjunct therapy for tuberculosis

5 Stress recovery may prove to be a promising approach to increase plant perfo

6 Quantification of TSPO levels in MS could prove to be a sensitive tool for evaluating in vivo the

7 oteomic response across seasons, which might prove to be a therapeutic target for disease prevention.

8 ne balance in fundamental interactions could prove to be a tunable feature in the rational design of

9 Thyroglobulin may prove to be a useful biomarker for both maternal and neo

10 er d for the laminates immersed in water has proved to be a challenge.

11 This, however, has proved to be a challenging analytical task due to the ul

12 roFIR guidelines where strictly followed and proved to be a crucial tool to guarantee data interchang

13 , permitting NPC-mediated matrix remodelling proved to be a generalizable strategy for stemness maint

14 n the Guadix-Baza Basin (southern Spain) has proved to be a great source of information for the Mioce

15 epression, however, its complex etiology has proved to be a major bottleneck in the identification of

16 Therefore, chia mucilage proved to be a new alternative for replacing fat in food

17 ADC proved to be a positive predictor of (18)F-FDG in the wh

18 with an N-(4-azidobutyl)carboxamide moiety, proved to be a potent inhibitor (Ki = 8.2 nM) of the The

19 paramagnetic relaxation enhancements (sPREs) proved to be a powerful method for probing protein-prote

20 Furthermore, this methodology proved to be a powerful strategy for investigating beta-

21 Compound 2 proved to be a powerful two-electron oxidant that can ad

22 The method under investigation proved to be a promising alternative to controlling cont

23 The proposed approach thus proved to be a promising alternative to produce powder-l

24 robustness, the coupled detection method was proved to be a promising platform for point-of-care test

25 Capillary electrophoresis proved to be a sensitive method for evaluating the exten

26 imer, guided by the knob-into-hole assembly, proved to be a stable conformation with homogeneous dist

27 AB setting proved to be a stand-alone scenario with the lowest seve

28 demonstrated that Calcein acetoxymethyl (AM) proved to be a suitable dye for detecting vital bacteria

29 Addition of WP proved to be a suitable tool to modulate the colour, the

30 Hilpda proved to be a target of hypoxia-inducible factor 1 (Hif

31 quid chromatography-tandem mass spectrometry proved to be a useful technique for determining the intr

32 Thus, modeling of the data proved to be a valuable analytical tool which provided a

33 S-LCC proved to be a valuable tool for policy analysis, but ad

34 In recent years, Au(I)-catalyzed reactions proved to be a valuable tool for the synthesis of substi

35 of enhancer activity in the human genome has proven to be a challenging problem.

36 HER2-positive breast cancer has long proven to be a clinically distinct class of breast cance

37 et sequence in the microRNA/target model has proven to be a more efficient strategy, accomplishing th

38 de-alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation stra

39 aphy tandem mass spectrometry (LC-MS/MS) has proven to be a powerful analytical tool for the characte

40 Although Cas9-mediated genome editing has proven to be a powerful genetic tool in eukaryotes, its

41 This approach has proven to be a powerful means for discovering how histor

42 4C-Seq has proven to be a powerful technique to identify genome-wid

43 A-guided endonuclease CRISPR/Cas9 system has proven to be a powerful tool for gene editing in a pleth

44 Flash nanoprecipitation (FNP) has proven to be a powerful tool for the rapid and scalable

45 Second-order nonlinear spectroscopy has proven to be a powerful tool in elucidating key chemical

46 Therefore, MD simulations have proven to be a powerful tool to predict functional diver

47 in various soil N-containing compounds have proven to be a robust tracer of soil N cycling, soil del

48 wing numbers of infections worldwide and has proven to be a significant challenge for vaccine develop

49 l dynamics of large multidomain proteins has proven to be a significant challenge.

50 The Vmh2-GFP fusion protein has proven to be a smart and effective tool for the study of

51 Fat grafting has proven to be a useful adjunct to breast reconstruction f

52 evels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advant

53 Dynamic combinatorial chemistry has proven to be a useful tool in achieving complexity, howe

54 ars, atomistic free energy calculations have proven to be a valid tool to complement experiments in c

55 protein fusions to herpesvirus capsids have proven to be a valuable method to study virus particle t

56 Three-dimensional (3D) printing has proven to be a versatile and useful technology for speci

57 cs, as the underlying mathematical tool, has proven to be a versatile approach to achieve such unusua

58 ed by dual-comb spectroscopy, which has been proven to be a versatile tool for obtaining one dimensio

59 eled analytically as well as numerically and proven to be a very capable instrument.

60 Prodrug strategies have been proven to be a very effective way of addressing delivery

61 ing as commonly used in computer science has proven to be a very efficient approach to build knowledg

62 Thus, ptxD/Phi has proven to be a very efficient, positive selection system

63 The marine environment has proven to be a very rich source of diverse natural produ

64 ApN proves to be a powerful protector of the skeletal muscle

65 Our robust method proves to be a promising alternative for the high-throug

66 unds and the encapsulation of garlic extract proves to be a promising technology for multiple applica

67 studies will show, whether cyclophosphamide proves to be a valuable alternative for the treatment of

68 ptical Frequency Comb Spectroscopy (DFCS) is proving to be a fundamental tool in many areas of scienc

69 Immunotherapy is proving to be a useful strategy in the treatment of viru

70 he balance between living and necrotic cells proved to be able to reproduce the experimental data obt

71 modeling - based on spin systems - has been proved to be accurate for a wide class of systems matchi

72 obleeds that were matched on histology, five proved to be acute and eight old microhaemorrhages.

73 in real samples and in proficiency tests and proved to be adequate for routine analysis.

74 symptoms, associations and generated models proved to be almost identical but weaker.

75 Recently, ABA has been proven to be also secreted and active in mammals, where

76 EGFR signaling in macrophages may prove to be an effective biomarker of CAC or target for

77 This may prove to be an effective strategy to improve the use of

78 Therefore, these drugs might prove to be an effective treatment by suppressing HK2 in

79 n uncontaminated mountain site during summer proved to be an effective decontamination procedure with

80 ree examples presented, the N-aryl component proved to be an effective photophysical device as it all

81 Targeted exome sequencing also proved to be an efficient and cost-effective strategy to

82 Geographic criteria were was proved to be an efficient delimitation method for onychi

83 In addition, the defect engineering is proved to be an efficient strategy to enhance the perfor

84 o account for the periodicity of prescribing proved to be an efficient way to capture its seasonal va

85 he blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce

86 oying (15)N-IGF1 as internal standard, which proved to be an essential feature of the IGF1 MALDImmuno

87 Thus, the genipin obtained in this work proved to be an excellent alternative to the use of glut

88 This PFAA Staudinger reaction proved to be an excellent bioothorgonal reaction.

89 ing gammadelta T (gammadeltaT-17) cells have proved to be an important early source of IL-17 in many

90 The use of a worst-rank analytical approach proved to be an important limitation of this study since

91 MDCT proved to be an important modality for decision-making i

92 aminated magnetic particles, which has been proven to be an appropriate carrier for enzyme immobiliz

93 starch gel (TC/SG) composite, which has been proven to be an appropriate carrier for enzyme immobiliz

94 tra, which means that Raman spectroscopy has proven to be an effective analytical approach in geology

95 privileged structures in drug discovery has proven to be an effective strategy, allowing the generat

96 rbation of the protein-protein interface has proven to be an efficient strategy to inactivate TNFalph

97 The Naming Game has proven to be an important model of opinion dynamics in c

98 actively 3 decades after its launch and has proven to be an important resource for information on HI

99 Interval estimation has so far proven to be an inadequate solution because it involves

100 The German version of the GSRS-IBS RDF proves to be an effective, reliable, and valid questionn

101 icantly, the isotopic record of Pb pollution proves to be an unparalleled proxy for tracking the urba

102 Immunotherapy is proving to be an effective therapeutic approach in a var

103 vity of the immune system against tumors are proving to be an effective therapeutic approach in multi

104 -C-(ethyltetrazol-2-yl)adenosine derivatives proved to be antagonists at hA3AR but agonists at the rA

105 t mass spectrometric detection (GCxGC/TOFMS) proved to be appropriate for this first simultaneous qua

106 The risk alleles of these SNPs were proved to be associated with the electrolytes metabolism

107 The aberrant activity of T4 PNK has been proven to be associated with a variety of human patholog

108 s can be produced in polynomial time and are proven to be asymptotically bounded by a theoretical opt

109 In 8 patients (1.0%), lesions were proven to be atypical metastases from PC.

110 re that treating or even preventing ARCH may prove to be beneficial for human health.

111 roenvironment in supporting HSC function may prove to be beneficial in treating age-related functiona

112 matic adjustments of the sample stage in xyz proved to be beneficial for analyzing nonplanar samples

113 tion 4 bearing large phenylalkyl side chains proved to be beneficial for MRP1 inhibition.

114 Daily administration of low-dose aspirin has proved to be beneficial in preventing recurrent cardiova

115 s proteasomal degradation and autophagy, has proven to be beneficial in maintaining cellular and card

116 actomannan (GM) and fungal DNA detection has proven to be beneficial in the diagnosis of IA.

117 Furthermore, these peptides prove to be broadly cytotoxic, causing cell death also i

118 Both assays proved to be capable of accurately differentiating betwe

119 In a competing process, the FLP proved to be capable of completely striping-off hydrogen

120 ave used a recently tested protocol that has proven to be capable of following the cytoplasmic change

121 Our proposed methodology proves to be capable of providing a promising solution f

122 od-like morphologies in certain bacteria has proved to be challenging due to an incomplete understand

123 inical tolerance in autoimmune diseases have proven to be challenging.

124 nt of an effective vaccine against HIV-1 has proven to be challenging.

125 This domino process proved to be chemo-, regio-, and stereoselective and all

126 These variants proved to be classifiable by their likely biological act

127 om temperature under mild conditions and has proven to be compatible with a variety of electron-donat

128 In addition, linear amides also prove to be competent substrates, and the phthaloyl-prot

129 The copper-promoted glycosylation was also proven to be completely orthogonal to the gold-promoted

130 The change-point test is proven to be consistent, and an error probability in cha

131 replications have value has, in particular, proven to be contentious.

132 patients with breast cancer liver metastasis proved to be cost-effective when compared with systemic

133 strain harboring the pIP501 plasmid and also proved to be cross-reactive against other clinically rel

134 The observed impairments proved to be decisive in vivo because silencing of the I

135 ulting in an enlargement of the windows have proven to be detrimental.

136 Pyreniporphyrin proved to be devoid of global aromatic character, but up

137 icient amounts of stable dsRNA in plants has proven to be difficult to achieve with conventional tran

138 o vary considerably between systems and have proven to be difficult to predict, spurring the need for

139 in cancer, but targeting lncRNAs in vivo has proven to be difficult.

140 Local photovoltaic current, proven to be driven by the bulk photovoltaic effect, has

141 Moreover, the vaccine effects proved to be durable, persisting for over eight months.

142 mixed in silico/in vitro approaches already proved to be effective first-line analytical tools.

143 The implantation of Ahmed valve proved to be effective treatment for these patients (IOP

144 The clean-up step which employed chitosan proved to be effective, since it reduced both the matrix

145 core with three boron atoms, and these have proven to be effective catalysts for a number of reactio

146 ber of mono- and bidentate ligands have also proven to be effective for accelerating C(sp(3))-H activ

147 The incorporation of BN units has proven to be effective in modulating the electronic prop

148 decades, cyclophosphamide treatment has been proven to be effective in patients with antibody-associa

149 New topical insecticide formulations have proven to be effective in preventing sand fly bites, and

150 If proven to be efficacious, these eating regimens offer pr

151 basic enzymatic purification protocol (BEPP) proved to be efficient while reducing 98.3 +/- 0.1% of t

152 Rabies virus-based vectors have been proven to be efficient dual vaccines against rabies and

153 copies of the matrix gene per reaction, and proved to be equivalent or superior to virus isolation i

154 The Top 3-ID-DIA strategy proved to be equivalent to the gold-standard ID-SRM in t

155 possess favorable solubility properties has proved to be especially challenging.

156 s, including the long isoform of MCL1, which proved to be essential for the antiapoptotic effect of I

157 CIL has been proven to be essential for NC migration in amphibians an

158 ins to protein function and pharmacology has proven to be exceedingly difficult in such large and com

159 mic supramolecular self-assembly of gelators prove to be excellent hosts for the incorporation of the

160 sing this information in subsequent analyses proved to be extremely helpful and is likely to become o

161 ynthesized compounds, while some derivatives proved to be extremely potent on a single target, compou

162 tissues, is important in many fields but has proven to be extremely challenging.

163 Such networks have been proven to be extremely useful, for the prediction of mec

164 The latter proved to be from native molecules that had intramolecul

165 Phosphodiesterases are proving to be fruitful targets for drug discovery.

166 is frustration-based model of allostery will prove to be generally important in explaining signaling

167 nds have NorA IC50 values lower than 5.0 muM proving to be good efflux pump inhibitor (EPI) candidate

168 ydropyran 3 could not be frozen at 100 K and proved to be heavily one-sided (if not anancomeric).

169 f the two-way security thresholds, which are proven to be higher than the corresponding one-way count

170 The predictions proved to be highly accurate, reliable, and unbiased and

171 o-metastatic phenotypes, and in advanced PCa proved to be highly associated with development of metas

172 The KF/crown ethers catalytic systems proved to be highly efficient in terms of yields and res

173 Of note, 1 and 2 proved to be highly sensitive to acid-mediated transform

174 n chronic lymphocytic leukemia, where it has proven to be highly active, even in patients with high-r

175 d, mathematically supported, methodology was proven to be highly appropriate and satisfactory for cap

176 oint inhibitors such as CTLA-4 and PD-1 have proven to be highly effective for the systemic activatio

177 , as well as stronger phosphoric acids, have proven to be highly effective in catalyzing a wide range

178 This methodology has proven to be highly effective in delivering miRNA molecu

179 e importantly, the nano-decorated sensor has proven to be highly effective in quantitative detection

180 This protocol has proven to be highly effective in the quantification of s

181 ministration (FDA)-approved drugs and it too proves to be highly effective.

182 on this effort, constant-mode nano-DESI MSI proved to be ideally suited for imaging biological sampl

183 ens become available, this methodology could prove to be impactful for identification of drug synergy

184 ntaminated equipment, vehicles, or personnel proved to be important for several livestock epidemics.

185 tified as likely having roles in attenuation proved to be important for virulence.

186 Although transcriptional regulation has proven to be important for keratinocyte differentiation,

187 , and how to molecularly manipulate it, will prove to be invaluable in designing crops optimized for

188 rate and physiologically relevant models are proving to be key in establishing appropriate platforms

189 al groups are presented, with N-substitution proving to be key to the reactivity of several substrate

190 endogenous genomic loci in living cells has proven to be laborious until the recent development of C

191 cal outcomes, and deletion of data that have proved to be less relevant or difficult to capture.

192 The diastase activity was proved to be lower than the respective in fresh honey, w

193 pigmented skin lesion on his left calf that proved to be melanoma with positive margins.

194 of the most powerful differentiation markers proved to be Mn content.

195 l fluorescent imaging and therapy, which may prove to be more broadly applicable.

196 This internal standard method proved to be more accurate than label-free quantitation

197 However, it has proved to be more challenging to base DRI values on chro

198 Reproducing drying rates proved to be more challenging, but improved if the addit

199 se proximity to the membrane, the shock wave proved to be more destructive to the protein due to form

200 of chaotropes at) the surface, the kinetics proved to be more difficult to treat.

201 At the acidic level, Ni NPs proved to be more effective in catalyzing CO2 dissolutio

202 This bimetallic W/Zr hydride precatalyst proved to be more efficient (TON = 1436) than the monome

203 pite being present at markedly lower levels, proved to be more pathogenic than a disease-causing coun

204 y employed glassy carbon electrode (GCE) and proved to be more sensitive toward the detection of all

205 Alemtuzumab, an anti-CD52 antibody, is proven to be more efficacious than interferon beta-1a in

206 Our method proves to be more rigorous than NIST's suite and Borel-N

207 Unexpectedly, intermittent stimulation proved to be most beneficial (60 pulses per second, for

208 r-associated genes between regions that were proven to be normal via histopathologic analysis (34 mut

209 identified as modulating virus infection may prove to be novel candidates for the development of ther

210 mploying 2-fluoroethoxyphosphonates that may prove to be of general value in organic synthesis.

211 n vivo arterial thrombosis studies have been proved to be of vital importance to elucidate the mechan

212 microscopy of many different organs and have proven to be of paramount importance in advancing our kn

213 igands directed toward D2-like receptors has proven to be of particular interest to improve the selec

214 avigating intratumoral drug distribution has proven to be one of the most challenging aspects of drug

215 nib treatment, suggesting that ponatinib may prove to be particularly advantageous for patients with

216 X-ray spectroscopic techniques have proven to be particularly useful in elucidating the mole

217 suppressing HK2 infectivity if these viruses prove to be pathogenic in cancer, neurological disorders

218 rol of cell function in general, the changes proved to be pivotal for proarrhythmic myofibroblast-car

219 accinia virus Ankara (MVA) boost vaccine has proven to be potent in eliciting antibody responses.

220 GBLUP-derived set tests proved to be powerful for detecting genomic features, he

221 rmation such as biological networks has been proven to be powerful in identifying disease-associated

222 bidirectional connections between IP and MnR proved to be primarily GABAergic.

223 roteins such as TAL effectors, has generally proved to be quite challenging.

224 extreme stability of the exosporium that has proven to be refractive to existing methods to deconstru

225 the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly t

226 itation of seven chemical markers in guarana proved to be reliable using a simple and convenient HPLC

227 The PCR-based method used in this study proved to be reliable, effective and, therefore, could b

228 The method proved to be reliable, precise and accurate.

229 responses, and the elevated B-cell responses proved to be remarkably durable, lasting more than 60 we

230 DLIT imaging proved to be reproducible and reliable throughout time.

231 f these overlaps at the onset of cytokinesis proved to be required to spatially confine membrane accu

232 1,3-Disiloxanediols proved to be robust and recoverable catalysts with no de

233 PEEK SPME-TM devices proved to be robust and were therefore used to perform e

234 tained and the proposed methodology has been proved to be robust, specific and sensible with a limit

235 Heteroatom-doped carbon nanomaterials have proven to be robust metal-free electrocatalysts for ORR

236 The method is proven to be robust with high-yield (>98%) over large ar

237 Endovascular management of SMAA proved to be safe and efficient.

238 VIT proved to be safe and no fatalities were recorded in the

239 pulmonary vasodilator treatment has not been proven to be safe and effective.

240 Thus far, it has proven to be safe and immunogenic, but it is expected th

241 the present study, therapy with HQ has been proven to be safe, with a relatively low rate of side ef

242 Several candidate measures have proven to be sensitive to the effects of gestational iro

243 lexity of the plasma proteome have, however, proven to be serious challenges and have often led to un

244 ants, both O2-consumption and aerobic growth proved to be severely impaired by sulfide when respirati

245 rreproducible levels of gene expression have proven to be significant challenges to pre-clinical to c

246 yst 4, with a turnover number (TON) of 9784, proved to be significantly more efficient than the silic

247 The method proposed proved to be simple and appropriate for the determinatio

248 14 proved to be soluble, kinase selective, and efficacious

249 e CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detai

250 This sequential approach proved to be suitable for the rapid generation of molecu

251 This methodology proved to be suitable to identify and quantify post-tran

252 with human mesenchymal stromal cells (hMSCs) proved to be superior in terms of HSC engraftment and lo

253 We generated Ube2w germ line KO mice that proved to be susceptible to early postnatal lethality wi

254 has been entirely convincing, and most have proved to be taphonomic artifacts, either undertracks or

255 Additionally, in our study, UAE proved to be the best extraction method with extraction

256 The volumetric measurement of the atrophy proved to be the best imaging biomarker, which allowed t

257 Cefoperazone and cloxacillin proved to be the less and the most heat-stable substance

258 The deacetyl glycoside of dihydroeugenol proved to be the most active compound against the bacter

259 coated with chitosan enriched with PPE (CHE) proved to be the most effective treatment in maintaining

260 Halogenated phenazine 14 proved to be the most potent biofilm-eradicating agent (

261 These highly preorganized molecules proved to be the most potent compounds of the series.

262 model; of these mutations, the E46K mutation proved to be the most toxic.

263 RuCl2(PPh3)3 has been proven to be the most efficient catalyst for this transf

264 SET-PT also proved to be thermodynamically unfavourable for all thre

265 Clinical research has proven to be too slow, unreliable, and expensive as cond

266 ectivity in complex chemical reactions could prove to be transformative.

267 exhaustive exploration had some success but proved to be unfeasible due to the massive number of alt

268 the dihydrazides 2, beyond simple isolation, proved to be unnecessary owing to the impurity rejection

269 Like clinical virus, this genome proved to be unstable in cell culture; however, propagat

270 Additionally, these observations may prove to be useful for the development of vaccine protoc

271 abnormalities in heart failure patients and prove to be useful in predicting response to CRT.

272 embedded within a large proteomic survey may prove to be useful in the evaluation of therapies to pre

273 thetic biology, where engineered RNATs could prove to be useful tools in biosensors and conditional g

274 Furthermore, the same nuclease treatment proved to be useful for sensitive and specific detection

275 by capitalizing on computational ideas that proved to be useful in assemblies of single cells and hi

276 Additionally, they proved to be useful to stain different blood cells with

277 Although protein-RNA free docking approaches proved to be useful, in general, the template-based appr

278 linear unbiased prediction (GBLUP) model has proven to be useful for prediction of complex traits as

279 Ion mobility spectrometry (IMS) has proven to be useful in separating isomer and isobar ions

280 ct as effective reverse-turn mimics and have proven to be useful intermediates for the preparation of

281 d in natural microRNA (miRNA) backbones have proven to be useful tools for RNA interference (RNAi).

282 The method was proven to be valid for the synthesis of a diverse librar

283 Moreover, IL-1alpha and IL-1beta might prove to be valuable targets for both prevention and tre

284 These models have also proven to be valuable experimental tools with which to e

285 High-dimensional flow cytometry is proving to be valuable for the study of subtle changes i

286 ectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain

287 Enoldiazo esters and amides have proven to be versatile reagents for cycloaddition reacti

288 nhibitors such as pacritinib or NS-018 could prove to be very useful additions to the therapeutic arm

289 EPhos with NaOPh as a mild homogeneous base proved to be very effective in the formation of 4-arylam

290 Importantly, the developed protocol proved to be very general and efficient for the substrat

291 ch clade was further characterized, and they proved to be very good singlet oxygen quenchers.

292 Overall, the proposed approach proved to be very worthy to study protein hydrolysis dur

293 g materials, such as metals and oxides, have proven to be very challenging.

294 n receptors specific for cancer targets have proven to be very efficient.

295 Hepatitis B vaccination has proven to be very safe and highly effective.

296 al strength relies on |gamma|(2), the method proves to be very sensitive and allows rapid screening o

297 methods for comparing protein sequences have proved to be viable alternatives to approaches that firs

298 wild-type virulence in vivo The fusion also proved to be well tolerated in herpes simplex virus.

299 highly efficacious, the vaccine formulation proved to be well-tolerated, demonstrating no elevation

300 dissociation (UVPD) using 193 nm photons has proven to be well-suited for activation and fragmentatio