ライフサイエンスコーパス: proven

1 on RT in LA-SCCHN and noninferiority was not proven.

2 environmental and food samples has not been proven.

3 ate socioeconomic factors in Africa has been proven.

4 but this hypothesis has never been formally proven.

5 reason their efficacy and safety are rarely proven.

6 autoimmune etiology is suspected but not yet proven.

7 ween Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosp

8 ributing to these declines, but viruses have proven a challenging pathogen to study in a bee model an

9 Cytokine inhibitors have definitively proven a critical role for tumour necrosis factor alpha

10 Such inhibition has proven a major challenge toward a complete biochemical c

11 of STING agonists via particle platforms has proven a more successful strategy, but the opportunity f

12 ive for spheres and negative for saddles-has proven a versatile tool to guide the self-assembly of de

13 outcomes of 20 patients with FMF and biopsy-proven AA amyloidosis that were transplanted between 199

14 ulfolane series led to compound 4, which has proven activity in an in vivo murine model of Mtb infect

15 ents who were operated on had pathologically proven acute appendicitis.

16 senting with symptomatic and sonographically proven acute isolated calf DVT.

17 Rates of biopsy-proven acute rejection (5.7% vs 7.9%), adverse events, a

18 Cumulative rates of biopsy-proven acute rejection (BPAR) from first randomization t

19 Biopsy-proven acute rejection and acute rejection were signific

20 Patients with histologically proven AH had higher levels of total and MV-bound M65 an

21 materials in flexible polymer materials has proven an effective way to achieve flexibility of functi

22 7) embodies the merger of a very potent and proven anabolic selective agonist of the prostaglandin E

23 Proven and cost-effective interventions are available fo

24 In this review, we systematically present proven and potential mechanisms by which sequence-specif

25 of the fatty acid quantification models was proven and the best classification of olive oils accordi

26 trasound and steam treatment application was proven and the optimal processing conditions were select

27 ppendicitis by utilizing histopathologically proven appendicitis and 6-week clinical follow-up as dia

28 Few clades of plants have proven as difficult to classify as cacti.

29 animal models and human clinical trials have proven ASOs both safe and effective.

30 and transmission and pathogenesis, given its proven association with fetal brain defects in pregnant

31 comparator cohort of 25 patients with biopsy-proven ATTR V122I amyloidosis recruited from September 1

32 Two patients had culture-proven bacterial endophthalmitis after DEX monoinjection

33 n aged between 40 and 70 years with a biopsy-proven BBD diagnosis.

34 5-HT4R selective drug intervention has been proven beneficial in subgroups of patients.

35 Treatment of subclinical rejections has only proven beneficial to histological and functional outcome

36 51 cancer cases and 51 controls with biopsy-proven benign lesions, matched by age and year-of-MRI.

37 e Center for Listeria (all microbiologically proven) between Nov 3, 2009, and July 31, 2013, in the c

38 rug-induced liver injury with histologically proven bile duct loss.

39 The versatility of the approach has been proven by successful implementation in three case studie

40 presence of multiple GMOs was unambiguously proven by the characterization of transgene flanking reg

41 Fifty adult patients with MIg and biopsy-proven C3G were extracted from the French national datab

42 0 were patients with newly diagnosed, biopsy-proven CA (65.5+/-10.8 years, 65% male, 62.5% amyloidosi

43 While SPMSs have proven capable of detecting microbes, these instruments

44 clinical trial open to patients with biopsy-proven carcinoma of the esophagus.

45 On the basis of proven cardiovascular and renal benefit, the antihypergl

46 of sonographic and CT images of 6 surgically proven cases of retained surgical sponges was undertaken

47 tic revision of all published histologically proven cases, this study aimed to describe the clinical

48 anaplastic large-T-cell lymphoma, had biopsy-proven CD30-positive tumours, had an Eastern Cooperative

49 We used a privileged scaffold with proven cellular potency as well as in vivo efficacy and

50 have been reported in the literature, it has proven challenging to achieve high binding selectivity f

51 suited for high-throughput schemes has been proven challenging to find.

52 ed paradigm-chronic social defeat stress-has proven challenging to implement in females.

53 tanding the fine details of this synergy has proven challenging to scientific research.

54 nor templates for targeted gene addition has proven challenging, which in turn has limited the capabi

55 dentifying optimal dosing of antibiotics has proven challenging-some antibiotics are most effective w

56 ganic semiconductors and their stability has proven challenging.

57 s, therapeutic targeting of this pathway has proven challenging.

58 iscovery of selective, direct activators has proven challenging.

59 ring of absorbers having such properties has proven challenging.

60 t reproducibility in microbiome research has proven challenging.

61 al, 273 patients with possible, probable, or proven chronic Q fever were included.

62 All patients had HCV infection and biopsy-proven cirrhosis, were Child-Pugh class A, and had no pr

63 21 board-certified dermatologists on biopsy-proven clinical images with two critical binary classifi

64 r practical appropriateness has not yet been proven clinically.

65 As ClusterTAD is based on a proven clustering approach, it opens a new avenue to app

66 Sera from 35 children with proven CMA (median age at inclusion of 10 months) were a

67 oss-of-function ACTB mutations have not been proven conclusively.

68 often with promising results, but have never proven curative.

69 ersistent inflammation, yet neutrophils have proven difficult cells to manipulate experimentally.

70 directly through spin relaxation effects has proven difficult due to competing relaxation mechanisms.

71 as the associated magnetic excitations have proven difficult to access with conventional techniques.

72 of the neocortex in human evolution, it has proven difficult to ascertain whether this extent of pre

73 f interaction have been proposed, but it has proven difficult to discriminate which ones are implemen

74 received considerable attention, yet it has proven difficult to measure monolayer and interfacial mo

75 ionships at the root of the animal tree have proven difficult to resolve, with the current debate foc

76 rtant determinant of T cell efficacy, it has proven difficult to selectively induce T cells of high f

77 However, it has proven difficult to test this hypothesis, and a direct l

78 ts as prolonged excruciating pain, which has proven difficult to treat.

79 ms governing protein-ligand interactions has proven difficult, with determination of entropic contrib

80 oducing paCOS with patterns of interest have proven difficult.

81 e and determining its behavioral impact have proven difficult.

82 plete eradication of established disease has proven difficult.

83 ake by the liver in live model organisms has proven difficult.

84 ents including 16 relapsed CLL and 9 RT (all proven diffuse large cell lymphoma) patients were enroll

85 s and in animal models of ALS, but have been proven disappointing in part because effective targets h

86 lts (n = 64) with a new diagnosis of culture-proven, drug-susceptible pulmonary tuberculosis immediat

87 ly reviewed for patients with pathologically proven ECD.

88 s brain-penetrant MT-stabilizing agents have proven effective against tau-mediated neurodegeneration

89 on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-indu

90 den of cardiovascular disease, we review the proven, effective approaches to the prevention and treat

91 ments with SHH or CXCR4 antagonists have not proven efficacious in clinical trials to date.

92 evacizumab) or VEGFR2 (ramucirumab) has been proven efficacious in colorectal cancer (CRC) patients.

93 research community, the only treatment with proven efficacy is early reperfusion of the occluded cor

94 cious vaccine against Ebola virus (EBOV) has proven elusive so far, but various inventive strategies

95 ivity of its putative endogenous ligands has proven elusive so far.

96 ation in the TP of bats that have heretofore proven elusive.

97 ndividual phenotypes and health outcomes has proven elusive.

98 y mediated by cellular immune responses, has proven elusive.

99 es for parcellating higher-order cortex have proven elusive.

100 ate behavior with individual neural data has proven elusive; even when successful, neural forecasts h

101 nts admitted to hospital with histologically proven EM.

102 1, 2014, and December 31, 2016, with biopsy-proven EMPD in whom HRCM was used to monitor treatment r

103 erostructures at such extreme dimensions has proven exceptionally challenging.

104 fty-three consecutive patients with a biopsy-proven extracardiac diagnosis of systemic sarcoidosis (2

105 fields; however, creating such materials has proven extremely challenging.

106 protein in glomeruli of patients with biopsy-proven focal segmental glomerulosclerosis (FSGS).

107 de polymorphisms (tag SNPs) in 367 challenge-proven food allergic cases, 199 food-sensitized tolerant

108 rs9325071 (AG) was associated with challenge-proven food allergy in the discovery sample (P=.001, OR=

109 IL13 rs1295686 was associated with challenge-proven food allergy in the discovery sample (P=.003; OR=

110 during early infancy to subsequent challenge-proven food allergy.

111 TBK1 protein levels reduced by 50% have been proven for specific in-frame deletions of 1 or several a

112 on of thiomolybdates could be experimentally proven for the first time in the reaction of MoO4(2-) wi

113 orption of sapotexanthin to human plasma was proven for the first time.

114 exponent of 2/3 in EC materials and the well-proven fractional dimensionality of 2.5 for ferroelectri

115 This approach has proven general for several different alkyl and aryl subs

116 st few years of life, for which there are no proven general therapies.

117 porting and Data System category 5 or biopsy-proven HCC and who were undergoing TAE were enrolled fro

118 only 34% to 60% of subjects with invasively proven HFpEF on the basis of resting echocardiographic d

119 This method has proven highly useful to monitor the Warburg effect in ca

120 masses assessed at diagnostic US with biopsy-proven histologic findings and BI-RADS 3 masses stable a

121 and Methods Consecutive patients with biopsy-proven HRLs who underwent surgery or at least 2 years of

122 mission duration in 376 patients with biopsy-proven idiopathic/primary MGN who achieved a remission a

123 nd 71.3% (57/80) in patients classified with proven IFD based on the European Organization for Resear

124 tween SPINK5 variant rs9325071 and challenge-proven IgE-mediated food allergy.

125 t a GWAS comparing 73 infants with challenge-proven IgE-mediated peanut allergy against 148 non-aller

126 While the first has been proven in the assessment of dynamic processes like cardi

127 Disease control has been proven in the metastatic and, to a limited extent, the a

128 Patients with a proven indication for a PPI should continue to receive i

129 Neuropsychological data have proven invaluable in advancing our understanding of high

130 arcinoma in situ (DCIS) components of biopsy-proven invasive breast cancer before surgery and (b) inv

131 table cardioverter defibrillator is the only proven lifesaving therapy; however, it is associated wit

132 he clinical activity of NAMPT inhibitors has proven limited, suggesting that alternative NAD(+) produ

133 eting the filarial endosymbiont Wolbachia, a proven macrofilaricide target, which reduces treatment f

134 ndred seventeen patients with histologically proven malignancy referred for clinical pBS were prospec

135 Methods Men with advanced PC (proven metastatic and/or castration-resistant biochemica

136 In particular, the domestic pig is a proven model of human physiology and an agriculturally i

137 lasses, such as retinal ganglion cells, have proven much more challenging to image.

138 ical trial involving 98 patients with biopsy-proven myeloma cast nephropathy requiring hemodialysis t

139 haracterized the plasma BA profile in biopsy-proven NAFL and NASH and compared to controls and (2) re

140 erum metabolomes of 535 patients with biopsy-proven NAFLD (353 with simple steatosis and 182 with NAS

141 characterized cohort of patients with biopsy-proven NAFLD, this study demonstrates that hepatic scar

142 ctivity and severity in patients with biopsy-proven NAFLD.

143 at the development of new antibiotics around proven natural scaffolds is the best short-term solution

144 ed guidelines, with emphasis on titration of proven neurohormonal therapies for HF.

145 programming in cancer, but targeting MYC has proven notoriously challenging.

146 Eligible patients had biopsy-proven oesophageal cancer that was unsuitable for curati

147 Patients with a history of IVDA and culture-proven or clinical evidence of fungal endophthalmitis we

148 h was collected for for 244 individuals (132 proven or obligate C9orf72 carriers), of whom 147 were c

149 s), of whom 147 were clinically affected (89 proven or obligate C9orf72 carriers).

150 atients with hydration status documentation, proven or presumed STEC infection, and some form of HUS

151 without radiographic abnormality (defined as proven or probable LRTI, respectively) or a positive upp

152 waiting surgical resection of histologically proven or radiologically suspected non-small cell lung c

153 al and should be considered malignant unless proven otherwise.

154 All PCR-proven P. malariae monoinfections in Israeli travelers b

155 e sections from 25 patients with genetically-proven pathogenic CI variants.

156 ty-five patients with clinical diagnosis and proven pathogenic variants in the ABCA4 gene.

157 ls and Methods Eighteen patients with biopsy-proven PCa provided informed consent to be included in t

158 Genetic determinants for challenge-proven peanut allergy include alleles at the HLA-DRB1 lo

159 y genetic variants associated with challenge-proven peanut allergy.

160 At present, there are no proven pharmacological treatments demonstrated to improv

161 ifications of an existing and experimentally proven phononic crystal design, the snowflake crystal.

162 Patients with biopsy-proven PMN and nephrotic syndrome after 6 months of noni

163 Among 361 (8%) patients with culture-proven pneumococcal disease, all clinical data were know

164 However, the use of pig has not proven popular due to technical difficulties and time re

165 suspected GBS during the outbreak, 30 had a proven presence of GBS, and 23 had a recent ZIKV infecti

166 T recipients and their donor pairs: 483 with proven/probable IA (183 SGM+) and 2126 with no IA by sta

167 For the clinical study, 211 samples from 10 proven/probable invasive aspergillosis (IA) and 2 possib

168 consecutive immunocompromised patients with proven/probable IPA were analyzed.

169 ble LRTI (12 of 45 [27%]) than in those with proven/probable LRTI (29 of 42 [69%]).

170 Patients presenting with proven/probable LRTI had a median of 16 fewer supplement

171 However, it has proven problematic to genotype STRs from high-throughput

172 proach that integrates components of several proven quality improvement methodologies to enhance safe

173 cific modification of natural antibodies has proven quite challenging.

174 Antifolates have a proven record as clinically used oncolytic agents.

175 ortion of children developing histologically proven recurrent acute appendicitis or a clinical diagno

176 e proportion of children with histologically proven recurrent acute appendicitis under active observa

177 under active observation had histologically proven recurrent acute appendicitis.

178 ound to combat infectious diseases that have proven refractory to classical approaches.

179 Biopsy-proven rejection was defined according to the Banff 2009

180 icted ACR events up to 40 days before biopsy-proven rejection.

181 on theories, well-crafted interventions have proven remarkably effective because they target specific

182 an age, 71.9 years +/- 10.9) with 217 biopsy-proven renal cell carcinoma tumors treated with thermal

183 aged 18 years and older with histologically proven, resectable oesophagogastric adenocarcinoma from

184 In summary, our technology was proven robust to obtain ground-based high-throughput pla

185 Gut microbiota has a proven role in regulating multiple neuro-chemical pathwa

186 structural-1 (NS1) protein from a clinically proven safe, Modified Vaccinia Ankara (MVA) vector, thus

187 of viral long-terminal-repeat enhancers have proven safe; however, transgene expression from cellular

188 The proven secretion and surface exposure of mCherry suggest

189 t, included 244 patients with pathologically proven serous ovarian cancer (mean age +/- standard devi

190 rgeted therapy in the equivocal group is not proven, so targeted therapy should not be considered for

191 The authors' basic theory has proven solid for the past 5 decades.

192 ged 60 years and older with angiographically proven stable ischaemic heart disease or stage 2 Global

193 olling patients with newly diagnosed, biopsy-proven stage III or IV squamous-cell carcinoma of the or

194 th PDFF and CAP helped detect histologically proven steatosis (>/=S1), but PDFF showed better diagnos

195 Antivascular therapy represents a proven strategy to treat angiogenesis.

196 gulants has been suggested, but has not been proven successful in improving clinically relevant outco

197 Uterus transplantation has proven successful when performed with a living donor.

198 few cell wall phenotyping methodologies have proven sufficiently precise, robust, or scalable for ass

199 ogous reaction using aldehyde substrates has proven surprisingly elusive.

200 onsecutive series of 55 patients with biopsy-proven SUSCC without bone invasion treated by wide surgi

201 nfirmed by significant downregulation of its proven targets, namely cyclin-dependent kinase 6 and Mcl

202 It has however proven technically challenging to study this parameter d

203 nitride stress capping layer is an industry proven technique for increasing electron mobility and dr

204 red electrodes are examined, and it has been proven that electric double layer (EDL) formed on porous

205 Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can serve as a power

206 It has been proven that micronization could improve the bioavailabil

207 Experiments performed to date have proven that real numbers are insufficient, but the need

208 It was anticipated early on, although never proven, that 2PG could also be a regulatory metabolite t

209 xplaining the associations of these loci has proven the main challenge.

210 If clinical benefit is proven, then the cost-effectiveness of screening for and

211 aneurysm in patients with FMD has yet to be proven, these data lend support to the recommendation th

212 No single marker has been proven to accurately categorize patients into their resp

213 of enhancer activity in the human genome has proven to be a challenging problem.

214 et sequence in the microRNA/target model has proven to be a more efficient strategy, accomplishing th

215 aphy tandem mass spectrometry (LC-MS/MS) has proven to be a powerful analytical tool for the characte

216 Although Cas9-mediated genome editing has proven to be a powerful genetic tool in eukaryotes, its

217 A-guided endonuclease CRISPR/Cas9 system has proven to be a powerful tool for gene editing in a pleth

218 Flash nanoprecipitation (FNP) has proven to be a powerful tool for the rapid and scalable

219 Second-order nonlinear spectroscopy has proven to be a powerful tool in elucidating key chemical

220 in various soil N-containing compounds have proven to be a robust tracer of soil N cycling, soil del

221 wing numbers of infections worldwide and has proven to be a significant challenge for vaccine develop

222 l dynamics of large multidomain proteins has proven to be a significant challenge.

223 The Vmh2-GFP fusion protein has proven to be a smart and effective tool for the study of

224 Fat grafting has proven to be a useful adjunct to breast reconstruction f

225 evels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advant

226 Dynamic combinatorial chemistry has proven to be a useful tool in achieving complexity, howe

227 ars, atomistic free energy calculations have proven to be a valid tool to complement experiments in c

228 protein fusions to herpesvirus capsids have proven to be a valuable method to study virus particle t

229 Three-dimensional (3D) printing has proven to be a versatile and useful technology for speci

230 cs, as the underlying mathematical tool, has proven to be a versatile approach to achieve such unusua

231 ed by dual-comb spectroscopy, which has been proven to be a versatile tool for obtaining one dimensio

232 eled analytically as well as numerically and proven to be a very capable instrument.

233 Thus, ptxD/Phi has proven to be a very efficient, positive selection system

234 The marine environment has proven to be a very rich source of diverse natural produ

235 Recently, ABA has been proven to be also secreted and active in mammals, where

236 aminated magnetic particles, which has been proven to be an appropriate carrier for enzyme immobiliz

237 rbation of the protein-protein interface has proven to be an efficient strategy to inactivate TNFalph

238 The Naming Game has proven to be an important model of opinion dynamics in c

239 Interval estimation has so far proven to be an inadequate solution because it involves

240 s can be produced in polynomial time and are proven to be asymptotically bounded by a theoretical opt

241 In 8 patients (1.0%), lesions were proven to be atypical metastases from PC.

242 s proteasomal degradation and autophagy, has proven to be beneficial in maintaining cellular and card

243 ave used a recently tested protocol that has proven to be capable of following the cytoplasmic change

244 inical tolerance in autoimmune diseases have proven to be challenging.

245 nt of an effective vaccine against HIV-1 has proven to be challenging.

246 om temperature under mild conditions and has proven to be compatible with a variety of electron-donat

247 The copper-promoted glycosylation was also proven to be completely orthogonal to the gold-promoted

248 The change-point test is proven to be consistent, and an error probability in cha

249 replications have value has, in particular, proven to be contentious.

250 ulting in an enlargement of the windows have proven to be detrimental.

251 icient amounts of stable dsRNA in plants has proven to be difficult to achieve with conventional tran

252 o vary considerably between systems and have proven to be difficult to predict, spurring the need for

253 in cancer, but targeting lncRNAs in vivo has proven to be difficult.

254 core with three boron atoms, and these have proven to be effective catalysts for a number of reactio

255 ber of mono- and bidentate ligands have also proven to be effective for accelerating C(sp(3))-H activ

256 decades, cyclophosphamide treatment has been proven to be effective in patients with antibody-associa

257 New topical insecticide formulations have proven to be effective in preventing sand fly bites, and

258 If proven to be efficacious, these eating regimens offer pr

259 CIL has been proven to be essential for NC migration in amphibians an

260 d, mathematically supported, methodology was proven to be highly appropriate and satisfactory for cap

261 This methodology has proven to be highly effective in delivering miRNA molecu

262 This protocol has proven to be highly effective in the quantification of s

263 Although transcriptional regulation has proven to be important for keratinocyte differentiation,

264 Alemtuzumab, an anti-CD52 antibody, is proven to be more efficacious than interferon beta-1a in

265 r-associated genes between regions that were proven to be normal via histopathologic analysis (34 mut

266 microscopy of many different organs and have proven to be of paramount importance in advancing our kn

267 igands directed toward D2-like receptors has proven to be of particular interest to improve the selec

268 Heteroatom-doped carbon nanomaterials have proven to be robust metal-free electrocatalysts for ORR

269 The method is proven to be robust with high-yield (>98%) over large ar

270 Thus far, it has proven to be safe and immunogenic, but it is expected th

271 lexity of the plasma proteome have, however, proven to be serious challenges and have often led to un

272 rreproducible levels of gene expression have proven to be significant challenges to pre-clinical to c

273 linear unbiased prediction (GBLUP) model has proven to be useful for prediction of complex traits as

274 Ion mobility spectrometry (IMS) has proven to be useful in separating isomer and isobar ions

275 ectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain

276 Enoldiazo esters and amides have proven to be versatile reagents for cycloaddition reacti

277 n receptors specific for cancer targets have proven to be very efficient.

278 dissociation (UVPD) using 193 nm photons has proven to be well-suited for activation and fragmentatio

279 y confer, and no medication has been clearly proven to cure or delay the progression of AD.

280 e bioaccessibility of the above nutrients is proven to differ in both the gastric and gastrointestina

281 molog) is a prominent oncogene that has been proven to drive tumorigenesis.

282 UPS-indel is theoretically proven to find all equivalent indels, and thus exhaustiv

283 hysiological technique is available that has proven to have good classification performance, and the

284 lectronic and magnetic behaviours, have been proven to play a crucial role in photovoltaic properties

285 In the European Arctic, this model has proven to simulate BC concentrations and source contribu

286 Interventions proven to work in other cultures should be introduced an

287 It was assumed that the new, proven treatments from these trials established new stan

288 There are no proven treatments.

289 duced fragmentation of analytes, ME-SIMS has proven useful for detection of numerous biorelevant spec

290 These detailed data have been proven useful for inferring disease transmission to a mo

291 Multicellular monolayer cultures have proven useful for investigating arrhythmias and other co

292 These proxies have proven useful for understanding the soil C cycle, which

293 We recommend techniques that have proven useful in each stage of the data analysis process

294 The prevalence of culture-proven UTI among pregnant women with UTI symptoms was 4%

295 of our approach, complementing the method's proven utility for Gram-positive bacteria.

296 Single-cell genome sequencing has proven valuable for the detection of somatic variation,

297 ifficult to study experimentally, but it has proven valuable to prepare and probe transition-state dy

298 Solid tumor perfusion is a proven variable of interest for predicting cancer aggres

299 urface plasmon resonance (LSPR) sensors have proven widely useful for studying lipid membrane configu

300 be related to focal iron deposits; this was proven with Perls staining in two patients.