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1 was socially proximal but not geographically proximal.
2 was geographically proximal but not socially proximal, 12% for each geographically and socially proxi
3 and MAPK3, major driver and modifiers of the proximal 16p11.2 600 kb BP4-BP5 syndromes, respectively.
11 di-ubiquitin chains containing differential proximal and distal isotopic labels and measuring USP7 b
12 pared chromatin interaction profiles between proximal and distal limb bud cells isolated from mutant
15 iated compound action potentials (C-CAPs) of proximal and distal peripheral nerve segments and dorsal
16 hoc, P < 0.05).Macronutrient delivery to the proximal and distal small intestine elicits different ou
18 re, we found PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine a
19 folds with basal medium, differentiated into proximal and distal tubules as well as endothelium, as h
25 ients with bicuspid aortic valve and dilated proximal ascending aorta, we sought to assess (1) factor
26 a bipartite structure composed of a membrane-proximal ATPase domain and a membrane-distal substrate-r
28 overexpression rab11 was mistrafficked into proximal axons, and these axons showed less retraction a
32 h displayed moderate expression and promoter-proximal BRD4 occupancy were most highly regulated and s
34 r each injecting peer who was geographically proximal but not socially proximal, 12% for each geograp
35 ny other non-communicable lung diseases, the proximal causes of many occupational lung diseases are w
38 Individuals showing at least two teeth with proximal (clinical AL) progression >/=3 mm over 5 years
39 of the secondary coordination sphere of the proximal CN(-) ligand (i.e., closest to the (4FeH) site)
40 1380 colorectal cancer cases: 690 cases with proximal colon cancer and 690 cases with distal colorect
41 erage clustering coefficient was 0.50 in the proximal colon cancer network and 0.30 in the distal col
44 bstantially associated with overall CRC, but proximal colon cancer risk was higher in the proinflamma
45 IDs, risks of overall CRC, colon cancer, and proximal colon cancer were higher in the highest quintil
46 r with higher connectivity in the network of proximal colon cancer, but not in distal colorectal canc
50 ur data suggest that lumen and mucosa in the proximal colon should be conceptualized not as stratifie
51 ubsite data were available, we observed 1264 proximal colon, 866 distal colon, and 670 rectal tumors.
54 ox coiled-coil (RBCC) domain in KAP1 and the proximal coupling of ubiquitin conjugation to ER degrada
56 al activity, whereas recruitment of CRTC1 to proximal CRE/TATA promoters depends on neuronal activity
57 yndrome frequently develops in patients with proximal deep-vein thrombosis despite treatment with ant
61 juvenile-to-adult transition is delayed, and proximal distal-patterning is abnormal in this mutant.
62 the mechanism of skeletal patterning along a proximal-distal axis has been an area of intense inquiry
64 distances felt bigger, one oriented with the proximal-distal hand axis (Along orientation) and one or
67 isease characterized by muscular weakness of proximal dominance, hypotonia, and respiratory insuffici
70 of the pivotal B-cell antigen receptor (BCR)-proximal effector spleen tyrosine kinase (SYK), which we
71 pe intermediates) and the observed effect of proximal electron-withdrawing groups upon the degradatio
72 YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the i
73 scanning a focussed optical beam across the proximal end of a coherent fibre bundle; high-frequency
74 , PBX1 is bound to the H1-compacted promoter/proximal enhancer of the neuron-specific gene doublecort
76 the known associations with the biologically proximal environmental factors alcohol consumption, body
77 vidence that sustained activation of EGFR in proximal epithelia is sufficient to cause spontaneous, p
78 ent cellular cytotoxicity favored a membrane-proximal epitope, whereas Ab-dependent cellular phagocyt
79 f acid reflux episodes and the percentage of proximal esophageal reflux off-PPI did not change signif
80 that TxA2 plays a critical role in the most proximal event of CLEC-2 signaling, i.e. the CLEC-2 rece
83 re, we present the structure of the membrane proximal external region (MPER) connected to the TM doma
84 rminants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan sit
86 t combines hydrophobic-at-interface membrane-proximal external region aromatics with hydrophobic resi
87 ions near the Cbeta H3 helix at the membrane-proximal face of the TCR, a region implicated in interac
88 ns as a soluble glycoprotein via its carboxy-proximal Fas1 domain and its normal cellular trafficking
90 is and inter- and intraoperator analyses for proximal femur stiffness, yield strain, yield load, ulti
93 lly, we find a higher percentage of promoter-proximal GR binding for genes regulated by GR across cel
95 x of the branched actin network promotes the proximal growth of the FA and contributes to a traction
98 ture: it drastically rearranges a network of proximal hydrogen bonds, modifying the local architectur
101 al, 12% for each geographically and socially proximal injecting peer, and 22% for each injecting peer
102 the number of socially and/or geographically proximal injecting peers and a person's injection status
105 water-soluble antimicrobials are limited to proximal interactions via aqueous diffusion, volatile an
106 ctivities, outputs (products), and outcomes (proximal, intermediate, distal) and applied retrospectiv
108 t Kog1/Raptor, which in turn allow the TORC1 proximal kinase Sch9/S6K1 to regulate the MT polymerase
111 al perturbations of drebrin demonstrate that proximal leading process microtubule-actomyosin coupling
112 cterized by ptosis, swallowing difficulties, proximal limb weakness and nuclear aggregates in skeleta
113 , (18)F-FLT uptake in the axial skeleton and proximal limbs assessed by SUVmax correlated with the gr
116 morphogenesis and progressive atrophy of the proximal lung endoderm with complete epithelial loss at
118 3.3; P < .0001 vs ERD, BE, and controls) and proximal (median, 5.0 cell layers to surface; IQR, 2.5-9
119 the intracranial internal carotid artery or proximal middle cerebral artery who had last been known
121 o explore the capabilities of a non-invasive proximal nerve stimulation technique in eliciting variou
122 oid-beta peptide (AbetaOs) are thought to be proximal neurotoxins involved in early neuronal oxidativ
123 filing of the distal (ischemia-affected) and proximal (non-affected) anterior myocardial regions were
124 fined the role of talin binding to the beta1 proximal NPxY motif in the developing kidney collecting
125 chains (PheK and FPheK) that can react with proximal nucleophilic residues to form intra- or intermo
130 presenting an endo or exo configuration and proximal or distal geometry, were activated in solution
133 f the HLA-A 3'UTR based on use of either the proximal or the distal PAS, which differ in length by 10
134 NTP's work on CrVI by external stakeholders (proximal outcome) and citations of NTP's research in sci
136 ted to larger organ and cap cell size in the proximal part of the hearing organ while in the distal p
137 distal PAS, with some alleles using only the proximal PAS, and others using both the proximal and dis
138 nscriptional enhancers regulate the promoter-proximal pausing of RNAPII, a key rate-limiting step req
140 ts suggest that KOW5 is involved in promoter-proximal pausing through contact with the nascent RNA.
141 nd tested their capacity to restore promoter-proximal pausing to DSIF-depleted Drosophila nuclear ext
142 tment levels tend to display Pol II promoter-proximal pausing, while Pol II recruitment and Pol II pa
144 leg position showed a widening of the right proximal physis below the right femoral head, with a med
145 ruitment, transcription initiation, promoter-proximal Pol II pause release, and transcription termina
150 to demonstrate that H3 histones at the Rgs10 proximal promoter are deacetylated in BV-2 microglia fol
151 ssive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event
152 active chromatin marks (acetylation) at its proximal promoter region as well as increased cyclic ade
153 lar analysis reveals that PRMT5 binds to the proximal promoter region of the AR gene and contributes
154 ndard exome capture, we included genome-wide proximal promoter regions that contain sequences that re
155 oincident hypermethylation of the PPARgamma2 proximal promoter; and elevated circulating adiponectin.
158 on (STAT) binding elements (SBEs) within the proximal promoters of the MMP-1 and MMP-3 genes, which i
160 chment of specific DNA motifs in the 1000 bp proximal promotor, some of which associate with known tr
163 teraction between the nitrogen lone pair and proximal radical center in angular 5,6-diethynylquinoxal
166 ear the -1.1 kb essential PRE, and also to a proximal region near -130 bp that contains PRE half-site
167 is preferentially integrated into the leader-proximal region of the CRISPR array, guided by the leade
168 C with more MT growth in the distal than the proximal region of the GC during repulsion, and knockdow
169 for a single amino acid within the membrane-proximal region of the GluA2 cytoplasmic tail, and sugge
170 mplex signaling component, p65, binds to the proximal region of the IL22 promoter and promotes transc
171 These residues are located in the membrane-proximal region of the N terminus of chECL1, suggesting
173 ions between lipid bilayers and the membrane-proximal regions of membrane-associated proteins play im
174 evious studies, we propose that Gene 33 is a proximal regulator of DDR that promotes DNA repair.
175 ally expressed proteins contain within their proximal regulatory regions sites that are bound by SOX6
176 intronic non-coding region, indicating that proximal regulatory sequences are sufficient for HPRT1 e
178 buminuria (aOR = 5.8; 95% CI = 3.7-9.0), and proximal renal tubular dysfunction (aOR = 7.0; 95% CI =
180 omal proteins, and the majority upstream and proximal ribosome binding sites, suggesting a regulatory
181 ral flow index as obtained during a 1-minute proximal right coronary artery (RCA) and left coronary a
182 the associations between anemia and multiple proximal risk factors (e.g., iron and vitamin A deficien
183 ause release and drive angiogenesis.Promoter proximal RNAPII pausing is a rate-limiting transcription
189 suggest that structural changes at the heme-proximal side, the globin domain-dimerization interface,
190 otably, mutation of Y192 blocks critical TCR-proximal signaling events and impairs thymocyte developm
191 aling pathway is a central axis in mediating proximal signaling events of TCR and CD28 engagement in
193 observe distinct kinetic profiles, even for proximal sites, and this suggests that target sequence a
201 d significant gene-expression changes in the proximal stromal compartment, and estrogen treatment uni
204 ine to form anthrax lethal toxin (LT), whose proximal targets are mitogen-activated kinase kinases (M
206 d no suppressed TCR response at the level of proximal TCR signaling (activation/phosphorylation of PL
209 termolecular beta-sheet between the membrane-proximal (third) Fibronectin type III domains (Fn3) of T
212 lated CpGs (DMCs; false discovery rate < 5%) proximal to 81 genes (across 14 chromosomes), of which 1
213 ddition, disruption of a conserved structure proximal to A1 caused a 10-fold reduction in all transcr
217 roteotoxicity and that PINK1 recruits Parkin proximal to focal misfolded aggregates of the mitochondr
218 F) requires both a PPI to deliver a protease proximal to its cleavage peptide and blue light to uncag
224 to the proper orientation of a flexible loop proximal to the dimer-dimer interface that is essential
226 because chelation anchors the organometallic proximal to the electrophilic, tetrasubstituted sulfone
228 rentially within the ring, multiple proteins proximal to the membrane form clusters of different size
230 usly reported P-CAB-free form, to a location proximal to the P-CAB binding site in the present BYK99-
235 on-depleted media and find that gene PA2374, proximal to the type VI secretion system H3 (H3-T6SS), f
236 tern basin of Lake Erie, including a station proximal to the water intake for the city of Toledo.
238 20 stabilizes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 t
242 c expression of epithelial cytokeratin 8.18, proximal tubular CD10, distal tubular cytokeratin 7, and
244 n peptide transporter 2 (PEPT2) expressed by proximal tubular cells mediates the reabsorption of ALA,
245 lysis of Pi transport in primary cultures of proximal tubular cells or in freshly isolated renal tubu
248 neys are initially affected with generalized proximal tubular dysfunction (renal Fanconi syndrome), t
249 r1 in the renal tubule exhibited generalized proximal tubular dysfunction indicative of Fanconi syndr
253 OX4 expression and activity at 24 h in renal proximal tubular epithelial cells, which was inhibited b
254 ential for zebrafish pronephric podocyte and proximal tubular function and that the ctns-mutant can b
257 In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and s
258 n is most abundantly expressed in the kidney proximal tubule and collecting duct epithelia, where it
259 ) intake decreased Na(+) reabsorption in the proximal tubule and increased it in distal segments with
261 al tubulointerstitial disease resulting from proximal tubule antigen-specific antibodies and immune c
262 tubular Na(+) reabsorption increased in the proximal tubule but decreased in the distal nephron beca
263 tubular Na(+) reabsorption decreased in the proximal tubule but increased in distal segments with lo
265 ectively, these findings indicate that renal proximal tubule cell CB1R contributes to the pathogenesi
266 ke of fluorescently labeled NEFA in cultured proximal tubule cells and microperfused rat proximal tub
267 that specific deletion of CB1R in the renal proximal tubule cells did not protect the mice from obes
269 s with ABBA disease who had a combination of proximal tubule damage, IgG-positive immune deposits in
274 pattern in which genes of the glomerular and proximal tubule lineages were either unchanged or upregu
275 iew that OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively m
276 We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapop
277 pared with the proximal tubule of males, the proximal tubule of females had greater phosphorylation o
281 w-level transfection of the collecting duct, proximal tubule, distal tubule, interstitial cells, and
282 a renal cystic model, ectopic p-Creb stained proximal tubule-derived cystic segments that lost the di
284 Using genetic murine models, we found that proximal tubule-specific deletion of Drp1 prevented the
288 RNA expression analyses revealed that kidney proximal tubules express transmembrane fatty acid transp
289 ture microdissection to obtain glomeruli and proximal tubules from 98 human needle kidney biopsy spec
290 g expression of NUPR1 in the nuclei of renal proximal tubules of injured human kidney allografts, but
291 vealed the metabolic signatures of S1 and S2 proximal tubules to be distinct and resolvable at the su
292 stering of macrophages around S1 segments of proximal tubules, and full renal protection required bot
293 in-dependent and -independent endocytosis in proximal tubules, phenocopying what has been reported fo
294 proximal tubule cells and microperfused rat proximal tubules, with greater uptake from the apical su
299 fic HLA-A alleles varied in the usage of the proximal versus distal PAS, with some alleles using only
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