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1 teractions between the PU.1 enhancer and its proximal promoter.
2 g to the hypoxia-response element in the AXL proximal promoter.
3 er hypoxia by directly binding the TGF-beta1 proximal promoter.
4 an enrichment of acetylated-histone on their proximal promoter.
5 conserved neural crest enhancer of the Pax3 proximal promoter.
6 AD, via distinct binding elements within the proximal promoter.
7 ds to a yet unidentified CRE site within the proximal promoter.
8 f direct binding of RBP-jkappa to the Nkx6.1 proximal promoter.
9 nhancer by looping its position close to the proximal promoter.
10 ription directly by binding two ROREs in its proximal promoter.
11 t of Wnt/beta-catenin signaling on the Runx2 proximal promoter.
12 ing to the GC-rich elements in the p21(Cip1) proximal promoter.
13 conserved ATTA sites located within the GnRH proximal promoter.
14 longation via the release of Pol II from the proximal promoter.
15 c-JUN and ATF2 to two AP-1 sites within the proximal promoter.
16 an NDR, whereas NANOG has a clear NDR at its proximal promoter.
17 a binding sites are conserved in the RCAN1-4 proximal promoter.
18 o T-cell factor/LEF-binding sites within the proximal promoter.
19 D response elements (VDREs) located near the proximal promoter.
20 ensus binding site/DA-motif in the rodent Th proximal promoter.
21 that TBX2 requires EGR1 to target the NDRG1 proximal promoter.
22 s binding to a 10-bp region of the TbetaRIII proximal promoter.
23 cription factors NF-Y and USF1 with the CP27 proximal promoter.
24 and three GC boxes, located within the Tesc proximal promoter.
25 interaction between a distal enhancer and a proximal promoter.
26 SNPs determined by sequence analysis of the proximal promoter.
27 a putative Gli binding site in the col15a1b proximal promoter.
28 of RNA polymerase II (Pol II) from the RPRM proximal promoter.
29 ional interaction by AP-2gamma at the CDKN1A proximal promoter.
30 lpha-binding consensus sequence in the ErbB3 proximal promoter.
31 by two HNF1 sites and two C/EBP sites in the proximal promoter.
32 tive hypoxia-response element in the miR-210 proximal promoter.
33 s mediated by two adjacent Ets motifs in the proximal promoter.
34 thylating the specific CpG sites on IL-1beta proximal promoter.
35 onarily conserved G:C-rich regions in the Th proximal promoter.
36 and this occurred only from an unannotated, proximal promoter.
37 r, proximal enhancer and downstream from the proximal promoter.
38 tial contact between a distal enhancer and a proximal promoter.
39 hypoxia-response element (HRE) in the PD-L1 proximal promoter.
40 reased histone methylation (H3K27me3) in the proximal promoter.
41 ation of distal CGIs, despite methylation at proximal promoters.
42 ed by p53 via p53 response elements in their proximal promoters.
43 he CYP3A4 (-243/-220) and CYP3A7 (-242/-219) proximal promoters.
44 sting regulation through regions outside the proximal promoters.
45 scription via tandem binding events at their proximal promoters.
46 dent on persistent STAT5 activation at these proximal promoters.
47 on the chromatin at 463 genomic positions in proximal promoters.
49 f its endogenous target, locating within the proximal promoter -242 site of the atrial natriuretic fa
50 cts, characterizing 2 common variants in the proximal promoter, A-296C and A-261T, using transfection
52 ntation-dependent positive regulator of IL13 proximal promoter activity in transiently transfected, a
53 quence fused to lacZ were generated and RPGR proximal promoter activity was analyzed by X-gal stainin
56 olymerase II 2 (ELL2) were recruited to this proximal promoter after P-TEFb release and were required
58 anscription regulatory domains: an inducible proximal promoter, an upstream silencer (PAUSE-1), and a
60 involves two principal regulatory regions, a proximal promoter and a distal enhancer located in the m
61 iR-200b approximately 200a approximately 429 proximal promoter and activates miR-200 expression in ep
62 protein kinase C, EGR1 directly binds to the proximal promoter and coordinates the nearby HNF4alpha (
63 s known about chromosomal loopings involving proximal promoter and distal enhancer elements regulatin
64 enic hormone-induced interaction between the proximal promoter and distal enhancer was confirmed in h
65 ases the degree of SIN3A binding to both the proximal promoter and enhancer of the Cyp1a1 gene and de
67 ered two conserved CArG boxes located in the proximal promoter and first intron of the human KCNMB1 g
68 eases in AAR-induced EGR1 binding within the proximal promoter and highly inducible binding to a site
69 tion initiating site, interacts with the MYC proximal promoter and induces orientation-independent MY
70 y, USF1 interacts with the E-box of the CP27 proximal promoter and NF-Y interacts with the CCAAT-box.
71 evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these protei
74 ect binding to an 11-bp fragment of the VEGF proximal promoter and that it functions as a negative re
75 t transcript of Runx3 that is derived from a proximal promoter and that produces functional protein i
76 raction of nuclear receptors with the Cyp7a1 proximal promoter and the expression of regulatory signa
77 This study reveals that Mesp1 binds to the proximal promoter and transactivates Etv2 gene expressio
78 silencer elements to directly interact with proximal promoter and transcription start sites, potenti
79 sequence (kappaB-site) was identified in the proximal promoter and was demonstrated to be required fo
80 resulted in fivefold activation of the CCN2 proximal promoter and, of importance, that small interfe
82 H3K9Ac), the enrichment of H3K9Ac in miR-29a proximal promoter, and miR-29a transcription in high glu
83 oincident hypermethylation of the PPARgamma2 proximal promoter; and elevated circulating adiponectin.
85 to demonstrate that H3 histones at the Rgs10 proximal promoter are deacetylated in BV-2 microglia fol
86 -1) response elements in the murine SerpinB2 proximal promoter are essential for optimal LPS-inducibi
87 ng lines but additional elements outside the proximal promoter are probably required for optimal tiss
88 d contain CLOCK:BMAL1 binding sites on their proximal promoters are likely to be clock-controlled TFs
90 hylation status of specific CpG sites of the proximal promoter, as well as by the actions of differen
91 use studies have shown that enhancers in the proximal promoter between -172/-1 bp of the ovine FSHB g
92 uding factors with strong preferences toward proximal promoter binding, factors that target intergeni
94 The use of DNase I accessibility to define proximal promoter borders revealed that about half of pr
95 usly characterized GC-rich region in the p21 proximal promoter but also by occupancy at a novel, phyl
96 ajority of TRbeta1 binding sites were not in proximal promoters but in the gene body of known genes.
97 anscription factor Yin Yang 1 (YY1) in their proximal promoters, but the physiological relevance is u
99 nd that SIRT1 is recruited to the E-cadherin proximal promoter by ZEB1 to deacetylate histone H3 and
100 wherein actions of ERalpha and Sin3A at the proximal promoter can overcome activating signals at dis
103 further define a 0.3-kb sequence including a proximal promoter (cluster A1) and an enhancer (cluster
104 Cotransfection of HepG2 cells with a CYP3A4 proximal promoter construct and expression vectors for t
105 we have identified a ternary complex at the proximal promoter containing TFAP2C, the oncoprotein Myc
106 ics analysis showed that the human SKIL gene proximal promoter contains a TGF-beta response element (
107 ethylation of a 4 CpG region upstream of the proximal promoter correlated inversely with gene express
108 chanisms relieve the elongation block at the proximal promoter: demethylation and recruitment of andr
109 issue and EMSA experiments with the human Th proximal promoter did not detect ER81 binding to the Th
114 s with the recruitment of HDAC2 to the hTERT proximal promoter, enhancing localized histone H3-K9 ace
115 e region between -128 and -88 as the minimal proximal promoter essential for basal transcription of A
119 ipitation we find dismissal of CtBP from the proximal promoter following DNA-damage, and that PARP1 a
121 Here, we report that DNA methylation of the proximal promoter for the type III deiodinase (dio3) gen
123 e GATA site in intron 8 (int-8-GATA) and the proximal promoter, forming a long-range loop to enhance
124 nalysis in zebrafish, we report here an etv2 proximal promoter fragment that prevents transgene misex
126 higher eukaryotes, these factors shield the proximal promoter from the action of more distant transc
128 ed transcription factor binding sites in the proximal promoters (from 100 bp to 5 kb upstream) of hum
132 ll cultures using methylated tissue-specific proximal promoters identified half-CRE (CGTCA) and half-
133 locates to the nucleus and binds to the CCN2 proximal promoter in an APF-dependent manner, providing
134 nscription factor (REST) occupied the Gabra6 proximal promoter in CGN progenitors and early postmitot
135 d NF-kappaB bind and/or are recruited on the proximal promoter in chromatin immunoprecipitation (ChIP
136 nd decreased HIF-2alpha binding to the MMP13 proximal promoter in chromatin immunoprecipitation assay
139 erved W/S-X-Y core module of the MHC class I proximal promoters, including the RFX factor components
141 ession through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates
142 ssed the transactivation activity of the E1b proximal promoter, indicating their importance as contri
143 on identifying and characterising the ALMS1 proximal promoter, initially by using 5' RACE to map tra
144 ription from the dnaA promoter and an origin-proximal promoter involved in replication initiation is
146 er, the ER81 binding site/DA-motif in the Th proximal promoter is poorly conserved in other mammals.
148 ary conservation of TFBEs within orthologous proximal promoters is closely linked to function, define
149 scriptional enhancer sequences interact with proximal promoters is poorly understood within the conte
151 f a G-rich sequence located within the c-KIT proximal promoter (kit2) in the presence of monovalent c
152 onsensus binding motif within the MIP-3alpha proximal promoter leading to increased protein secretion
153 l promoter located upstream of lmo1569 and a proximal promoter located upstream of the lmo1568 gene.
154 II remain accumulated or "bookmarked" at the proximal promoter long after transcription has terminate
155 the expression variance is not explained by proximal promoter methylation, with the exception of gen
157 ining a cAMP response element (CRE) in their proximal promoter, more than half of which are conserved
158 ic variation at the NPY locus, especially in proximal promoter nabla-880Delta, disrupts glucocorticoi
159 pared tumor necrosis factor alpha (TNFalpha) proximal promoter nucleosome alignment in endotoxin-resp
160 demonstrated that EWS-WT1 directly bound the proximal promoter of ASCL1, activating its transcription
162 ied a highly conserved 13-bp sequence in the proximal promoter of COX4I2 that functions as an oxygen
163 EMSA identified a ZBP-89-binding site in the proximal promoter of CTNNB1 Reciprocally, siRNA-mediated
164 inant GPATCH3 protein activated in vitro the proximal promoter of CXCR4, a gene involved in embryo ne
166 d that hypoxia response element sites in the proximal promoter of ET-1 and ET-BR were required for th
167 potential ERRalpha response elements in the proximal promoter of human OPN showed that ERRalpha and
168 ulation, we identified a 70-bp region in the proximal promoter of IDOL, distinct from that containing
169 ed a functional cAMP response element in the proximal promoter of Lrrtm2, indicating that at least Lr
171 tation revealed that Kdm5b is present at the proximal promoter of Reln, and H3K4me3 methylation was i
172 interactions between the distal enhancer and proximal promoter of rhodopsin and long/medium-wavelengt
174 monstrated enhanced binding of the AR to the proximal promoter of the CEBPB gene in the presence of d
175 l ROR response element was identified in the proximal promoter of the FGF21 gene and shown to exhibit
179 that endogenous Prox1 directly binds to the proximal promoter of the Olig2 gene locus, as well as to
183 iated with an increase in methylation of the proximal promoter of the serotonin transporter gene, whi
187 intergenic regions and gene bodies flanking proximal promoters of a large cohort of transcriptionall
189 ofiling the dynamic interaction of p300 with proximal promoters of human T cells identified a class o
190 ated CREB constitutively associated with the proximal promoters of many of the induced target genes i
191 NLRC5 associates with and transactivates the proximal promoters of MHC class I genes, although the mo
193 he methylation of different CpG sites in the proximal promoters of the human MMP13 and IL1B genes mod
194 on (STAT) binding elements (SBEs) within the proximal promoters of the MMP-1 and MMP-3 genes, which i
198 ACs) differentially bind to various RAREs in proximal promoters or enhancer regions of RA-regulated g
199 d potentially deliver RNA polymerase II to a proximal promoter, or alternatively might function direc
201 ssive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event
202 cers in gene-rich neighborhoods, rather than proximal promoters, preventing straightforward assignmen
203 nsulin in non-tumor pituitary cells, but the proximal promoter region (nucleotides -496/+1) responds
204 CAF was increasingly recruited to the MMP-13 proximal promoter region after PTH treatment, and this w
205 I, p300, Oct4, Sox2, and Tet1 from the Nanog proximal promoter region and with no increase in repress
206 active chromatin marks (acetylation) at its proximal promoter region as well as increased cyclic ade
207 Vascular endothelial growth factor (VEGF) proximal promoter region contains a poly G/C-rich elemen
213 ecipitation revealed that MYST3 binds to the proximal promoter region of ERalpha gene, and inactivati
217 tional repressor complex mSin3A-HDAC1 at the proximal promoter region of OGA and correspondingly decr
218 essor Fep1, which strongly associates with a proximal promoter region of shu1(+) in vivo in response
220 lar analysis reveals that PRMT5 binds to the proximal promoter region of the AR gene and contributes
222 hippocampal cell line stably expressing the proximal promoter region of the arginase 1 gene fused to
223 hat IkappaBzeta is directly recruited to the proximal promoter region of the Ccl2 gene and is require
224 th this suggestion, Brd4 associates with the proximal promoter region of the Gli1 locus, and does so
226 The polypurine/polypyrimidine tract in the proximal promoter region of the human RET gene (-51 to -
228 g a construct consisting of a portion of the proximal promoter region of the mouse COX-2 gene upstrea
229 y forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetyla
230 s indicate that FoxO1 can associate with the proximal promoter region of the srebp1 gene and disrupt
233 -quadruplexes have been shown to form in the proximal promoter region of VEGF and are amenable to sma
235 estrogen-response element located within the proximal promoter region that is also targeted by ERalph
236 on between remote enhancer sequences and the proximal promoter region through "looping" of intervenin
237 ypoxia response elements in the human eIF4E1 proximal promoter region to activate eIF4E1 expression.
238 d that constitutively bound ELK1 at the EGR1 proximal promoter region was phosphorylated after AAR ac
241 d CtBP-responsive repression elements to the proximal promoter region, and found ZBRK1 overexpression
246 he research effort in this area has examined proximal promoter regions and epigenetic alterations at
247 nhancer-binding protein delta (C/EBP) to the proximal promoter regions and STAT3 to the distal promot
248 elements mediate chromatin accessibility in proximal promoter regions and the repeat content of prom
249 distinguishes binding between distal versus proximal promoter regions as well as the 3' ends of gene
250 evealing, and sequencing the IER3 coding and proximal promoter regions of 74 MDS patients disclosed n
251 Site-specific CpG methylation within the proximal promoter regions of approximately 14,500 genes
252 binding domain of ER and is recruited to the proximal promoter regions of ER target genes upon gene i
253 differential patterns of DNA methylation in proximal promoter regions of most (eg, CD31, von Willebr
254 sly found that SUMO-1 marks chromatin at the proximal promoter regions of some of the most active hou
255 ndard exome capture, we included genome-wide proximal promoter regions that contain sequences that re
256 romoters are common and are more likely than proximal promoter regions to show differentiation-specif
257 ture is its ability to detect REs outside of proximal promoter regions, as it takes advantage of the
258 t or susceptible, share the identical coding/proximal promoter regions, but vary in the upstream regu
259 n-specific enhancer, I12b, and the Dlx1/Dlx2 proximal promoter regions, through repressor E2F sites b
260 binding peaks show a striking enrichment in proximal promoter regions, with 52% located within 1 kb
263 e comprise the necessary cis-elements of the proximal promoter required for both constitutive and ind
266 wo additional mutations within the conserved proximal promoter sequence (c.-274T>G and c.-307T>C).
268 variants in a conserved region of the OVOL2 proximal promoter sequence in the index families (c.-339
275 Strongest association was observed at the proximal promoter single nucleotide polymorphism (SNP) r
276 n was significantly associated with the IL-6 proximal promoter single nucleotide polymorphism (SNP) r
278 gamma binding sites in the CYP3A7 and CYP3A4 proximal promoters suggests that regulation of basal pro
280 cate that NF-Y is not merely a commonly used proximal promoter TF, but rather performs a more diverse
283 stic regulation of KIRs by the bidirectional proximal promoter, the specificity of inhibitory KIRs on
284 duced VDR/RXR binding to the VDRE-containing proximal promoter, the VDR/RXR heterodimer also localize
286 tively, of the polyG/polyC tract in the VEGF proximal promoter under conditions that favor the transi
287 leotide polymorphism analyses indicated that proximal promoter variant nabla-880Delta (2-bp TG/-, Ins
288 ring the chromatin structure around the HAS2 proximal promoter via O-GlcNAcylation and acetylation.
290 diabetes in adulthood, the CpG island in the proximal promoter was methylated, resulting in permanent
291 rope-specific regulation associated with the proximal promoter was observed as expected, but the mode
292 by activator protein 1 (AP-1) binding on the proximal promoter was sensitive to inhibition of de novo
293 stitutions at positions -331 and -164 in the proximal promoter were each sufficient to account for th
295 xpression from both distal promoter (Pd) and proximal promoter, whereas MS-275 and ATO induced gene e
296 ession of STARS in vitro activates the STARS proximal promoter, which contains a conserved SRF site.
297 an enhanced binding of HDAC3 to the sGCbeta1 proximal promoter, which could be reversed by panobinost
299 atin immunoprecipitations of the osteocalcin proximal promoter with antibodies against Runx2 demonstr
300 models specifically in the CR1 region of its proximal promoter, with the insertion of a nucleosome an
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