ライフサイエンスコーパス: proximal tubule cell

1 al, and functional similarities to the renal proximal tubule cell.

2 in the kidney, is a potent mitogen for renal proximal tubule cells.

3 ing of Npt2a to the apical membrane of renal proximal tubule cells.

4 rapid uptake of the protein predominantly by proximal tubule cells.

5 device (RAD) containing 10(9) porcine renal proximal tubule cells.

6 ulation of the Na(+),K(+)-ATPase activity in proximal tubule cells.

7 s, and functional aspects in cultured murine proximal tubule cells.

8 to take place across the apical membrane of proximal tubule cells.

9 f the glomerular membrane and vacuolation of proximal tubule cells.

10 om mitochondria into cytosol in cultured rat proximal tubule cells.

11 transporters (OATs), which are expressed in proximal tubule cells.

12 tly localized at internal sites in the renal proximal tubule cells.

13 n highly expressed on the apical membrane of proximal tubule cells.

14 not pendrin, on the brush border membrane of proximal tubule cells.

15 ll cAMP-dependent Cl(-) conductance in mouse proximal tubule cells.

16 embranes enriched in megalin in L2 cells and proximal tubule cells.

17 adenovirus, was detected primarily in renal proximal tubule cells.

18 f mitochondrial respiration in human primary proximal tubule cells.

19 and the CD21 antigen are found primarily in proximal tubule cells.

20 ities may be coordinately regulated in renal proximal tubule cells.

21 cotransporter kinetics were studied in renal proximal tubule cells.

22 measured in primary cultures of rabbit renal proximal tubule cells.

23 a 1B-AR but not alpha 1D-ARs regulate NHE in proximal tubule cells.

24 event in cell death after hypoxic injury in proximal tubule cells.

25 cant avenue for the entry of this toxin into proximal tubule cells.

26 lathrin-coated pits on the apical surface of proximal tubule cells.

27 ium bicarbonate cotransporter was studied in proximal tubule cells.

28 substrate accumulation in cystinotic kidney proximal tubule cells.

29 h normal-appearing and poorly differentiated proximal tubule cells.

30 roid hormone-stimulated cAMP accumulation in proximal tubule cells.

31 rption of tubularly-filtered proteins by the proximal tubule cells.

32 gial cells, glomerular endothelial cells, or proximal tubule cells.

33 h conditioned media from serum-starved mouse proximal tubule cells.

34 n regulating paracellular transport of renal proximal tubule cells.

35 d pathophysiologic albumin concentrations in proximal tubule cells.

36 antagonism decreased fibronectin in cultured proximal tubule cells.

37 d fusion with the basolateral membrane in S1 proximal tubule cells.

38 ll growth inhibition and cell death in renal proximal tubule cells.

39 ained its efficacy to scavenge superoxide in proximal tubule cells.

40 oxalate crystals to inhibit their uptake by proximal tubule cells.

41 h border enzymes of the CPP before uptake by proximal tubule cells.

42 (-) across the basolateral membrane of renal proximal tubule cells.

43 cal in FSS-induced modulation of V-ATPase in proximal tubule cells.

44 d a decrease in phosphate transport in renal proximal tubule cells.

45 R transcriptional regulation occurs in renal proximal tubule cells.

46 ed transcription of proinflammatory genes by proximal tubule cells.

47 ocyte cell membrane and brush borders of the proximal tubule cells.

48 mitochondrial morphology and respiration in proximal tubule cells.

49 angial, cortical epithelial, epithelial, and proximal tubule cells.

50 ubule cells and an increase in proliferating proximal tubule cells after ischemic injury.

51 and protein kinase C (PKC) activity in renal proximal tubule cells, an effect that was abolished by S

52 nected from ERK activation in cultured renal proximal tubule cells and also in renal proximal tubules

53 pical (AP) and basolateral (BL) membranes in proximal tubule cells and both receptor sites undergo en

54 have reduced clathrin-coated pits in kidney proximal tubule cells and excrete specific plasma protei

55 undant levels of APOL1 mRNA were observed in proximal tubule cells and glomerular endothelial cells,

56 nificance of this interaction in human renal proximal tubule cells and HEK293 cells stably expressing

57 closporine A (CsA) treated and control human proximal tubule cells and identified mRNAs undergoing ac

58 Finally, in (32)P-labeled wild-type proximal tubule cells and in opossum kidney cells, dopam

59 characterizes the development of atrophy in proximal tubule cells and may contribute to the renal pa

60 ke of fluorescently labeled NEFA in cultured proximal tubule cells and microperfused rat proximal tub

61 for the involvement of AQP1 in migration of proximal tubule cells and possibly in the response of th

62 e, consistent with a pathway of synthesis in proximal tubule cells and release into the tubular lumen

63 wth factor (TGF)-beta1 mRNA in mesangial and proximal tubule cells and that treatment with anti-TGF-b

64 as localized to the brush border membrane of proximal tubule cells and was demonstrated to mediate Cl

65 detected by immunocytochemistry primarily on proximal tubule cells and was markedly upregulated in th

66 ted with defective HCO(3)(-) reabsorption in proximal tubule cells) and hypokalaemic periodic paralys

67 reach the primary filtrate, are captured by proximal tubule cells, and are endocytosed.

68 ion initiates its translocation to the renal proximal tubule cell apical membrane and the internaliza

69 AT2R activation increased renal proximal tubule cell apical membrane AT2R protein (P<0.0

70 Renal proximal tubule cells are responsible for the reabsorpti

71 Proximal tubule cells are thought to secrete AngII or pr

72 lowing Bax translocation in ATP-depleted rat proximal tubule cells, Bak, a proapoptotic molecule that

73 The nuclei of kidney proximal tubule cells became polyploid in a similar way

74 In proximal tubule cells, both pNBC1 and kNBC1 exhibit a 3

75 We detected Klotho in the proximal tubule cell, brush border, and urinary lumen, w

76 receptor not only on the luminal surface of proximal tubule cells but also on the luminal surfaces o

77 - 1.8%) inhibited NHE3 activity in wild-type proximal tubule cells but neither forskolin (-3.2 +/- 3.

78 2)R antagonism occurred selectively in renal proximal tubule cells but not in renal endothelial cells

79 rs is antagonized by adenosine reuptake into proximal tubule cells by equilibrative nucleotide transp

80 ated kidney slices of the mouse and in mouse proximal tubule cells by processes involving mitogen-act

81 uded that albumin induces apoptosis in human proximal tubule cells by stimulating mitochondrial apopt

82 e-1 (KIM-1) is markedly upregulated in renal proximal tubule cells by stimuli that promote dedifferen

83 ating agents are transported from blood into proximal tubule cells by the basolateral membrane organi

84 During recovery by regeneration after AKI, proximal tubule cells can fail to redifferentiate, under

85 amatically prevents injury of cultured renal proximal tubule cells caused by myeloma light chains thr

86 ectively, these findings indicate that renal proximal tubule cell CB1R contributes to the pathogenesi

87 Moreover, in pig kidney proximal tubule cells, cisplatin-induced mitochondrial t

88 In cultured proximal tubule cells, cofilin was distributed in nuclea

89 Primary cilia were elongated in proximal tubule cells, collecting duct cells and parieta

90 to identify the conditions under which adult proximal tubule cells could be directly transcriptionall

91 hat inhibition of HMG-CoA reductase in renal proximal tubule cells could reduce receptor mediated-end

92 d significantly diminished cisplatin-induced proximal tubule cell death in vitro.

93 NHERF-1(-/-) proximal tubule cells demonstrate defective regulation o

94 experiments using primary cultures of renal proximal tubule cells derived from wild-type and NHERF-1

95 Kidney proximal tubule cells developed severe energy deficits d

96 that specific deletion of CB1R in the renal proximal tubule cells did not protect the mice from obes

97 w affinity/high capacity route of entry into proximal tubule cells during hyperglycaemia.

98 When examined in a primary culture of human proximal tubule cells endogenously expressing the CRLR-R

99 autocrine TGFbeta signaling in proliferating proximal tubule cells exceeds the levels that are necess

100 In AQP1-transfected, cultured proximal tubule cells, fluid shear stress or the additio

101 unidentified sites on the luminal surface of proximal tubule cells followed by endocytosis and degrad

102 ata indicate that rapid delivery of siRNA to proximal tubule cells follows intravenous administration

103 e expression profiles in nondiseased primary proximal tubule cells from black patients revealed that

104 ral transduction of p21 completely protected proximal tubule cells from cisplatin toxicity.

105 Infection of proximal tubule cells from NHERF-1 null mice with adenov

106 HE activity in freshly isolated and cultured proximal tubule cells from SHR and Wistar-Kyoto (WKY) no

107 nsport in brush border membrane vesicles and proximal tubule cells from sodium-hydrogen exchanger reg

108 als challenged with a low phosphate diet and proximal tubule cells from these animals cultured in a l

109 igration was compared in primary cultures of proximal tubule cells from wild-type and AQP1 null mice.

110 rder membrane vesicles and in cultured renal proximal tubule cells from wild-type but not from NHERF-

111 Primary cultures of rabbit renal proximal tubule cells grown under improved culture condi

112 in mice that expressed somatic ACE (sACE) in proximal tubule cells (Gs strain) or germinal ACE in the

113 AngII) receptors on the luminal membranes of proximal tubule cells has been recognized for many years

114 in proteasomes in HEK cells and human renal proximal tubule cells heterologously and endogenously ex

115 gated apoptotic mechanisms in cultured human proximal tubule cells (HKC-8) that were exposed to endot

116 ey cells expressing high Gb3 (cultured human proximal tubule cells [HPT]) were compared with non-kidn

117 ed NHE3 expression (-50+/-9%) in human renal proximal tubule cells (hRPTCs).

118 blot analysis of primary cultures of normal proximal tubule cells identified a 140-kDa protein, conf

119 of both apical and basolateral membranes of proximal tubule cells in both sustained and recovering A

120 signaling mechanisms were examined in rabbit proximal tubule cells in culture.

121 rface of hepatocytes and the luminal side of proximal tubule cells in the kidney, while not expressed

122 ant renal cells, the latter identified as S3 proximal tubule cells in the outer medulla by in situ hy

123 HSP-25 expression is increased in the proximal tubule cells in the outer stripe of the outer m

124 Rat proximal tubule cells in tissue culture, when challenged

125 proliferating cell nuclear antigen-positive proximal tubule cells, in a punctate cytoplasmic distrib

126 t age-associated lysosomal defects in kidney proximal tubule cells, in the absence of frank CNS patho

127 ng brush border membranes and cultured renal proximal tubule cells indicate a specific requirement fo

128 II (Ang II) stimulation of AT1 receptors in proximal tubule cells induces the recruitment of Na+,K+-

129 Murine NHERF-1-/- renal proximal tubule cells infected with adenovirus-GFP-NHERF

130 n whom Galpha(s)-mediated signaling in renal proximal tubule cells is defective.

131 or AQP1 in kidney involving the migration of proximal tubule cells is reported.

132 demonstrate that metabolism of cisplatin in proximal tubule cells is required for its nephrotoxicity

133 entify K(+)-selective conductances in single proximal tubule cells isolated from frog kidney and to e

134 These data suggest that single proximal tubule cells isolated from frog kidney contain

135 In summary, in single proximal tubule cells isolated from frog kidney, on stim

136 identified a Cl- conductance (GCl) in single proximal tubule cells isolated from frog kidney, which w

137 ocated on the basolateral membrane of single proximal tubule cells isolated from frog kidney.

138 d alanine transport on cell length in single proximal tubule cells isolated from frog kidney.

139 Compared with primary renal proximal tubule cells isolated from KIM-1Deltamucin mice

140 RTL-5 cells and on an immortalized rat renal proximal tubule cell line (IRPT cells), was obtained by

141 ences in more detail, the immortalized human proximal tubule cell line HK-2 was used in an in vitro m

142 sion in the recovery of cell adhesion in the proximal tubule cell line JTC-12 after peroxide injury.

143 s in vitro model of ATP depletion in a human proximal tubule cell line reproduces the pattern of gene

144 ogous expression of KIM-1 in an immortalized proximal tubule cell line triggered MCP-1 secretion and

145 Endosomal acidification in a proximal tubule cell line was partially sensitive to inh

146 In MCT cells, a mouse renal proximal tubule cell line, ATP depletion by antimycin A

147 A mouse renal proximal tubule cell line, deficient in electrogenic sod

148 In a renal proximal tubule cell line, either pharmacologic or genet

149 esent studies utilizing a well characterized proximal tubule cell line, LLCPKcl4, we determined that

150 atin-induced apoptosis in the DR3(+/+) mouse proximal tubule cell line, TKPTS.

151 ction of kNBC1 expressed heterologously in a proximal tubule cell line.

152 LC5 were investigated in the LLC-PK1 porcine proximal tubule cell line.

153 timulates NHE3 transport activity in a model proximal tubule cell line.

154 TNF-alpha and MCP-1 transcription in a human proximal tubule cell line; this effect was associated wi

155 ules and Slc27a2(-/-) or FATP2 shRNA-treated proximal tubule cell lines compared with wild-type or sc

156 sociated with lysosomal membranes in control proximal tubule cell lines suggesting that OCRL may func

157 ule assist device (RAD) containing 109 renal proximal tubule cells may be a new therapeutic approach

158 nhibition of HMG-CoA reductase by statins in proximal tubule cells may reduce tubular protein reabsor

159 Phosphorylation of cofilin in two proximal tubule cell models (porcine renal proximal tubu

160 In NHERF-1-null proximal tubule cells, neither PTH nor dopamine inhibite

161 In freshly isolated proximal tubule cells, NHE activity was elevated almost

162 ) reabsorption across the apical membrane of proximal tubule cells occurs via Cl(-)-formate exchange.

163 elling induced by Na+-alanine cotransport in proximal tubule cells of the frog kidney is followed by

164 An antibody to myosin-VIIb labeled proximal tubule cells of the kidney and enterocytes of t

165 Addition of purified TSP-1 to normal kidney proximal tubule cells or cells subjected to ATP depletio

166 daily from the glomerular filtrate by kidney proximal tubule cells (PT), requiring ferrireductase act

167 In wild-type primary proximal tubule cells (PTC), we observed a time-dependen

168 Mouse proximal tubule cells (PTCs) were subjected to 5 h of FS

169 Proximal tubule cells (PTCs), which are the primary site

170 nsfer, expression of NHERF-1 in NHERF-1(-/-) proximal tubule cells restored the inhibitory response t

171 Primary cultures of mice proximal tubule cells retain selected regulatory pathway

172 In vitro studies using immortalized rat proximal tubule cells revealed that 50 pmol/l TGF-beta1

173 2 (GLUT2) during diabetes may lead to renal proximal tubule cell (RPTC) injury, inflammation, and in

174 odulates AT1 receptor expression in cultured proximal tubule cells (RPTC) expressing DA1 receptors.

175 Exposure of renal proximal tubule cells (RPTC) to the oxidants tert-butyl

176 ct of catalase (Cat) overexpression in renal proximal tubule cells (RPTCs) on nuclear factor erythroi

177 Human renal proximal tubule cells (RPTECs) were used to characterize

178 In vitro studies revealed that proximal tubule cells secrete pro-AOAH, which can be tak

179 Cultured proximal tubule cells showed regulated signaling that wa

180 Differentiated proximal tubule cells showed upregulation of specific ge

181 on of gallein on normal rat kidney (NRK-52E) proximal tubule cells significantly reduced (P < 0.05) S

182 To obtain proximal tubule cell-specific data, the impact of oxidan

183 tubule cells was confirmed in cultured human proximal tubule cells subjected to in vitro ischemic inj

184 e receptor-2 promoter-driven Cre-transfected proximal tubule cells, suggesting that knockdown of stan

185 educed amounts of megalin and cubilin at the proximal tubule cell surface in Rab38 knockout versus co

186 The Na+/H+ exchanger NHE1 regulates proximal tubule cell survival through interaction with p

187 ) may directly, and differentially, increase proximal tubule cell susceptibility to superimposed atta

188 Kidney proximal tubule cells take up Krebs cycle intermediates

189 In rat proximal tubule cells that express endogenous AT1R and D

190 angiotensinogen and angiotensinogen mRNA in proximal tubule cells, the data indicate that AngII or p

191 e for all three alpha 1-AR subtypes in mouse proximal tubule cells through reverse transcription-poly

192 conditioned media from high glucose-treated proximal tubule cells to induce transmigration of mononu

193 TGF-beta1, we exposed confluent human renal proximal tubule cells to TGF-beta1 and observed a signif

194 In vitro, exposure of proximal tubule cells to the inflammatory cytokines IFN-

195 2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta i

196 icated to provide a structural framework for proximal tubule cells to transmit mechanical forces and

197 pha 1-AR subtypes that regulate NHE in mouse proximal tubule cells, two strategies were used: (i) ant

198 Immediately after the onset of albuminuria, proximal tubule cells underwent a transient burst of pro

199 logously expressed in BS-C-1 cells or rabbit proximal tubule cells, uniform cytosolic and nuclear flu

200 ucing TGF-beta1-induced disruptions of renal proximal tubule cell uptake of albumin.

201 In primary cultures of mouse renal proximal tubule cells, uric acid uptake was significantl

202 specifically targets an antioxidant to renal proximal tubule cells via the folate receptor.

203 ism by which cisplatin selectively kills the proximal tubule cells was heretofore unknown.

204 intracellular redox-signaling pathway in the proximal tubule cells was well within levels that are se

205 Because AGT is expressed in renal proximal tubule cells, we hypothesized that its loss may

206 In iron-challenged, cultured proximal tubule cells, we observed a positive correlatio

207 In cultured mesangial cells and proximal tubule cells, where both PPARalpha and -gamma w

208 cated in the brush border membrane of kidney proximal tubule cells, where it mediates renal urate sec

209 Jade-1 is abundant in proximal tubule cells, which are clear-cell renal cancer

210 fect on NHE3 activity in opossum kidney (OK) proximal tubule cells, which lack expression of endogeno

211 Treatment of cultured proximal tubule cells with mouse recombinant sclerostin

212 Infection of NHERF-1-null proximal tubule cells with wild-type adenovirus-GFP-NHER

213 on the apical brush-border membrane of 786-O proximal tubule cells within the OOC surface, and the re