ライフサイエンスコーパス: proximate

1 We hypothesized that Ras proximate 1 (Rap1) functions as an additional target for

2 ntegrins is mediated by the small GTPase Ras-proximate-1 (Rap1).

3 The GTPase Ras-proximate-1 (Rap1b) is upregulated in the hyperglycemic

4 Two major pathways contribute to Ras-proximate-1-mediated integrin activation in stimulated p

5 most on minerals and trace elements (34.8%), proximates (24.5%), amino acids (15.3%) and (pro)vitamin

6 Here we provide a proximate account for this behavior by showing that indi

7 t that our own process model offers a better proximate account of self-control fatigue.

8 tivation of the unreactive C-OMe bond by the proximate amide directing group using catalytic RuH2(CO)

9 Here, we define the proximate amino acids between the actin filament and the

10 The proximate analyses revealed that the composite bread had

11 Proximate analysis and antioxidant assays were done usin

12 Proximate analysis and light micrographs revealed higher

13 Physicochemical analysis, proximate analysis and rheology properties of LH-butter

14 er demand for herbal foods is increasing and proximate analysis has shown that Stevia also contains f

15 from NMR spectroscopy, GC, 3D-TLC as well as proximate analysis permitted the observed growth paramet

16 Mushroom proximate analysis revealed significant variations of co

17 Proximate analysis showed that Andean cereals have simil

18 These were measured through proximate analysis, inhibition assays and HPLC.

19 which a pair of cysteine side chains become proximate and can then be selectively induced to undergo

20 In this work proximate and mineral profile of Andean cereals cultivat

21 were significant (p<0.05) differences in the proximate and some mineral and vitamin composition of th

22 hen the side-chain atoms become unphysically proximate and the van der Waals repulsion becomes too la

23 ; (b) the theoretical pitfalls of conflating proximate and ultimate causation; (c) the role of develo

24 He argued that proximate and ultimate causes addressed different questi

25 this error, I clarify the difference between proximate and ultimate causes of cooperation and punishm

26 Moreover, it supports the connection between proximate and ultimate causes of masting: indeed, large-

27 We also discuss proximate and ultimate causes of size variation and how

28 n biology, in which he distinguished between proximate and ultimate causes.

29 cause they did not distinguish clearly among proximate and ultimate causes.

30 ontribute to a fruitful articulation of such proximate and ultimate explanations of human morality.

31 hors' case, such as a failure to distinguish proximate and ultimate explanations.

32 but also because of a frequent conflation of proximate and ultimate explanatory levels that Guala's r

33 Our results provide insights into both the proximate and ultimate factors that underlie evolved mig

34 Studies that combine proximate and ultimate mechanisms offer great promise fo

35 two fundamental questions: (i) what are the proximate and ultimate mechanisms underlying age-related

36 nd thus suggest an opportunity for a unified proximate and ultimate theory of Bayesian animal brains,

37 Metabolic explanations are both proximate and ultimate, in the same way genetic explanat

38 Moreover, nutritional composition (proximates and vitamins) and bioactive compounds content

39 Integrating these ultimate and proximate approaches, we introduce dual-process cognitio

40 on junctions in the vicinity of structurally proximate bases.

41 e and rapid triplet energy transfer from the proximate benzophenone units to the dibenzobarrelene gro

42 After accounting for proximate biotic factors such as trophic level (delta(15

43 ly involving nonadjacent bases that are made proximate by folding.

44 bond interacts in a "head on" fashion with a proximate C-H bond.

45 uctases catalyze the metabolic activation of proximate carcinogenic PAH trans-dihydrodiols to yield e

46 These interpretations of proximate causal factors should be regarded as hypothese

47 Consideration of both ultimate and proximate causation goes beyond philosophical cogitation

48 Mayr equated proximate causation with immediate factors (for example,

49 Although fire was the primary proximate cause of 1989-2008 deforestation (93%) and net

50 that reduced expression of VEGF-A is not the proximate cause of capillary regression in OIR.

51 Although evolution of resistance remains the proximate cause of death in most cancer patients, a rece

52 this disease has the potential to impact the proximate cause of death in most patients with scleroder

53 ne failure at the cellular scale is the most proximate cause of death.

54 n of the discordance in monozygotic twins, a proximate cause of mental disorders in individuals with

55 and operations that were unlikely to be the proximate cause of mortality and were instead a marker o

56 It is believed that nonadherence is the proximate cause of multidrug-resistant tuberculosis (MDR

57 mmation of the heart (or myocarditis) is the proximate cause of myocardial dysfunction, causing injur

58 tions of mutant huntingtin with NMDARs are a proximate cause of neurodegeneration in HD.

59 )-mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disea

60 The proximate cause of skipping seems to be insufficient ene

61 electron-electron interactions that are the proximate cause of such SC are more typically drivers of

62 tly and therefore decreases fitness, but the proximate cause of this cost is not clear.

63 onance spectroscopy analysis showed that the proximate cause was an unusually high level of intracell

64 reciprocity suffers from a confusion between proximate causes (psychological mechanisms triggering be

65 We investigated the proximate causes and evolutionary patterns of red flower

66 at does not clearly distinguish ultimate and proximate causes and their reciprocal relations.

67 argets of such interventions, as well as the proximate causes of ageing-related degeneration and dise

68 st extend beyond estimating GFCL to identify proximate causes of forest cover loss and to estimate re

69 Many proximate causes of global amphibian declines have been

70 e, and inadequate clinical responses are the proximate causes of GVHD-related deaths.

71 tage of excess risk mediated (PERM) by these proximate causes of secondary mitral regurgitation was o

72 tive functionalist framework to identify the proximate causes of teaching behaviour in both humans an

73 Although proximate causes of this phase polyphenism have been wid

74 al, whereas floods and human disturbance are proximate causes.

75 sit-amplifying domain, after the division of proximate cells, implying that the determination of stem

76 that exert a passive inertial lift force on proximate cells, thus enabling gentler manipulation of t

77 Proximate chemical composition and iron, zinc and dietar

78 content, microbiological characteristics and proximate chemical properties were observed.

79 work has begun to investigate cooperation's proximate cognitive underpinnings using a dual-process f

80 were found in the nutritional compositions (proximate components, amino acids, minerals, vitamins an

81 Proximate composition analysis and antinutritional facto

82 Proximate composition and functional characteristics of

83 Morphological characteristics; proximate composition and functional compounds were anal

84 gated the changes produced by canning in the proximate composition and in the bioactive constituents

85 Proximate composition and microbiological characteristic

86 In the present study, proximate composition and mineral content on the leaves

87 ficant influence (P>0.05) on the colour, pH, proximate composition and overall sensory acceptability

88 icochemical properties, textural properties, proximate composition and sensory characteristics of the

89 Proximate composition and specific technological propert

90 Proximate composition in the flesh were not modified sig

91 ferences were found in the yields and fillet proximate composition of the two groups.

92 to accessions from eight cultivar groups for proximate composition traits, major sugars, acids and an

93 The proximate composition was significantly affected (P<0.05

94 on, pasting properties, reconstitution test, proximate composition, amino acids, minerals and electro

95 Proximate composition, fatty acid profile, cholesterol,

96 e effects of fermentation and malting on the proximate composition, mineral content, amino acids and

97 A study on the proximate composition, minerals, vitamins, carotenoids,

98 Nonetheless, despite some similarities in proximate composition, mussels presented differences in

99 Proximate composition, pH, acidity, instrumental texture

100 Proximate composition, pH, cooking loss (CL), colour and

101 a pyrifolia tubers was characterized for its proximate composition, physicochemical properties and to

102 The proximate composition, phytic acid, in vitro protein dig

103 e the effects of polishing and parboiling on proximate composition, structure, phenolic compounds, an

104 skin flour (GSF), and oligofructose (OLI) on proximate composition, total phenolic content (TPC), ant

105 fficients due to subtle differences in their proximate composition.

106 t there was no significant difference in the proximate composition; however vacuum dried CPI (VDCPI)

107 ein (GPC) and amylose content (AC) of BR and proximate compositions (protein, crude oil, moisture, as

108 At control and lower NPK rates, the proximate compositions and antioxidant profile of pumpki

109 the control and the highest fertilizer rate, proximate compositions decreased by 7-62% while the anti

110 Proximate compositions varied with portions tested.

111 Proximate compositions were determined, as well as the t

112 measured parameters, mature fruit had higher proximate contents and higher antioxidant concentrations

113 In this study, the total phenolics, proximate contents, and antioxidant, anti-inflammatory,

114 This study was designed to measure the proximate controls of potential CH4 oxidation in semiari

115 and 5a is due to the promoting effect of the proximate COOH group.

116 Cys-1327 and Cys-1337 as the AGA-responsive proximate cysteines.

117 on motivations to achieve objectives as the proximate determinants of behavior.

118 Guided by a "proximate determinants" approach, we focus here on patte

119 Only named in 1999, Bd is a proximate driver of declines in global amphibian biodive

120 nto wilderness or frontier areas are a major proximate driver of habitat loss and fragmentation, wild

121 ed to humans, this implies that an important proximate driver of obesity should be food insecurity ra

122 nd remote sensing method to quantify the key proximate drivers (i.e., replacement land uses) of mangr

123 Major proximate drivers of change in disease dynamics include

124 rnance regimes between 2006-2011; (ii) their proximate drivers; and (iii) whether state PAs, CCs and

125 reflect local resource availability, but the proximate ecological and social forces that determine th

126 beta-Amyloid (Abeta), a potential proximate effector of neurotoxicity in AD, might exert c

127 evolved physiological trade-offs versus the proximate effects of temperature for interspecific varia

128 However, proximate effects of temperature played an increasingly

129 The competition between proximate electronic phases produces a complex phenomeno

130 We then highlight two proximate emotional social comparison reactions linked w

131 followed immediately by antigen formation on proximate endothelial cells.

132 mainland Britain and 400 years earlier than proximate European sites.

133 ermore, by comparison with the reactivity of proximate even-electron clusters, we demonstrate that th

134 omeostasis, and endothelial dysfunction is a proximate event in the pathogenesis of atherothrombosis.

135 r hybrid male sterility factors, providing a proximate explanation for the large X-effect.

136 The model's more proximate explanation, however, falls short of accountin

137 e need to differentiate between ultimate and proximate explanation; the insurance hypothesis (IH) nee

138 multicellular organisms, we hope to uncover proximate explanations for "how" it causes disease in hu

139 ons, avoiding the conflation of ultimate and proximate explanations that has long hindered research o

140 illiams et al. identify S. pombe Scm3 as the proximate factor in the Cnp1/CENP-A deposition pathway,

141 ultimately related to climate, but with the proximate factors largely unknown.

142 Proximate, fatty acid composition, vitamin and mineral c

143 t the top of the cortical plate, as a likely proximate force for tangential expansion that then leads

144 The presence of the proximate free radical masks the chromophore's usual flu

145 al adaptive changes that are specific to the proximate function of their cognate organ(s).

146 ed significantly indicating cross-linking of proximate fusion proteins suggesting that damage of resi

147 ontrolling for physical distance, introns of proximate genes are most different in skew if they have

148 d habitat divergence in vertebrates, but the proximate genetic mechanisms that underlie complex patte

149 gesting that migration across even spatially proximate groups is limited relative to mutational gener

150 xial coordinating amino acid, as well as the proximate H(N)(backbone)-S(Cys) hydrogen bond, were disc

151 C3'* to C2'* conversion in the presence of a proximate H3O(+) has a barrier in agreement with the exp

152 he loss of HF from C3'* in the presence of a proximate H3O(+) is barrierless resulting in C2'* format

153 t C2'* formation via HF loss induced by this proximate H3O(+).

154 xplained thrombocytopenia/thrombosis without proximate heparin exposure and with anti-PF4/heparin IgG

155 thrombotic thrombocytopenic disorder without proximate heparin exposure serologically indistinguishab

156 This question can be understood either as a proximate "how" question or as an ultimate "why" questio

157 ther we can ignore ecological context (e.g., proximate human impacts, trophic level, spatial scale) a

158 ation/C-O cyclization reaction directed by a proximate hydroxyl group has been developed.

159 d that the N-terminus and the C-terminus are proximate in solution, and that the middle of the protei

160 rol sulfur isotope fractionation through the proximate influence of intracellular metabolites.

161 MEK1 is the proximate kinase for activation of ERK1/2, and nuclear t

162 nsulator alpha-RuCl3 is thought to realize a proximate KQSL.

163 On the proximate level, we propose that it is mainly the high n

164 suggesting a role for LAPTM5 at the receptor-proximate level.

165 A proximate Lewis basic group facilitates the mild dehydro

166 In addition, proximate life events such as chronic stress have docume

167 ne the effect of boiling and roasting on the proximate, lipid oxidation, fatty acid profile and miner

168 ified by immunoprecipitation, and a membrane-proximate localization of Beclin-1 was shown by immunoel

169 ing rice seeds, we determined the number and proximate location of their cis-localization elements by

170 cision of interlocus distance of genomically-proximate loci was better than 4% of the cell length.

171 ished in 1999, McMichael's "Prisoners of the Proximate: Loosening the Constraints on Epidemiology in

172 on its short cytoplasmic domain, to date the proximate mechanism by which this RAGE domain engages an

173 ggest that intergenomic epistasis can be the proximate mechanism for social parasitism in ants, revea

174 f barn swallows in contaminated areas, and a proximate mechanism for the demographic effects document

175 t that reinforcement learning may be a major proximate mechanism governing MCC behavior.

176 rred sperm morphologies and thus represent a proximate mechanism of female mate choice when ejaculate

177 border, both the evolutionary trajectory and proximate mechanism of FSD remain unclear.

178 eory, but also treats culture as more than a proximate mechanism that is directly controlled by genes

179 ortance of further studies to understand the proximate mechanisms acting to buffer the negative effec

180 However, the proximate mechanisms behind these intergenerational effe

181 questions about the selective pressures and proximate mechanisms driving cognitive change-have the p

182 Resources are clearly involved in the proximate mechanisms driving masting, but resource budge

183 wo chickadee species helps us understand the proximate mechanisms driving species responses to climat

184 ith high stress- and disease-resistance, but proximate mechanisms for this trait association remain e

185 an explain attractiveness benefits, but what proximate mechanisms might serve as efficient causes of

186 Understanding the proximate mechanisms of caste development in eusocial ta

187 ds are ideal organisms to study ultimate and proximate mechanisms of hormone-dependent behavior and n

188 eural phenotypes, providing insight into the proximate mechanisms that control behavior.

189 argue that a recent surge of studies of the proximate mechanisms that underlie search behavior offer

190 ade significant progress in ascertaining the proximate mechanisms underlying convergent phenotypes, l

191 Our results illuminate proximate mechanisms underpinning recent aspen forest mo

192 d units at lower levels should be studied as proximate mechanisms.

193 er among species and identify the underlying proximate mechanisms.

194 e welcome the various suggestions made about proximate mechanisms.

195 ry can evolve irrespective of the underlying proximate mechanisms.

196 This influence is possibly due to two proximate mechanisms: kin priming through communication

197 The identification of a proximate mediator of HPA-inhibitory limbic influences p

198 Tethering also required proximate membrane anchoring of the PDZ domain, suggesti

199 coupling between the ligand radical and the proximate metal ion.

200 hat originates from the redox synergy of two proximate metal ions in combination with the potentially

201 All nine samples were analysed for proximate, mineral, vitamin and antinutrient composition

202 work aims at evaluating the main nutrients (proximate, minerals), their contribution for Dietary Ref

203 transgenerationally in the germ line and the proximate modifications involving chronic restraint stre

204 ic level is still limited with regard to the proximate molecular factors that both promote and constr

205 specifically the interaction of the QD with proximate molecules.

206 h has been interpreted as originating from a proximate Mott transition.

207 ding between the bound amino alcohol and the proximate N-oxide group.

208 Proximate neural mechanisms that influence preferences f

209 rt studies showing that similarity acts as a proximate neurobiological mechanism where prosocial beha

210 id beta-protein (Abeta) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD).

211 nce showed that seed coat colour varied with proximate nutrients, Ca, Fe, and Vit C.

212 The study investigated, for the first time, proximate nutritional composition and antioxidant activi

213 f the penecontemporaneous and geographically proximate OH 7 partial hand skeleton (part of the Homo h

214 show remarkable behavioral differences, the proximate origins of which remain unknown.

215 system performance may consider using valid proximate outcomes like critical deterioration in additi

216 The factor inhibiting HIF (FIH) is a proximate oxygen sensor for human cells, hydroxylating A

217 ibit two cofacial aniline rings that favor a proximate, parallel arrangement of covalently attached c

218 enerally broadened by their interaction with proximate paramagnetic NV(-) centres through coherent an

219 ypothesis of Alzheimer's disease is that the proximate pathologic agents are oligomers of the amyloid

220 hat an iron-driven increase in phi(m) is the proximate physiological mechanism affected by iron addit

221 ulates PKACbeta, transcriptionally forming a proximate positive feedback loop.

222 ne marrow (BM), but the identity of the most proximate prethymocytes has remained controversial.

223 EST and REST binding sites in NSCs and their proximate progenitor species.

224 There was an increased risk for higher proximate prolactin levels [RR, >15.7 vs. </=8.1 ng/mL (

225 termined total nitrogen content to determine proximate protein composition.

226 living cells, BioID permits the labeling of proximate proteins during a defined labeling period.

227 tect protein-protein associations as well as proximate proteins in living cells.

228 hing and those that escape to effect CALI of proximate proteins.

229 mentation, and exhibits enhanced labeling of proximate proteins.

230 HLH-1 binding did not predict proximate regulatory action overall, despite enrichment

231 esses associated with stress, and attributed proximate, regulatory function.

232 Our aim was to analyse whether the proximate relationship between between-group competition

233 n-Octane serves as a proximate reservoir supplying O2 to result in partial ox

234 d by neurons in the nucleus accumbens drives proximate reward bias by promoting impulsive approach to

235 expenditure and delay to reward; therefore, proximate reward bias was unlikely to be caused by effor

236 provide the first experimental evidence that proximate risk of predation can increase the intensity o

237 We identify new gene products that play a proximate role in skeletal morphogenesis and uncover tra

238 populations than they were to geographically proximate rural areas - the one exception being urban an

239 If antibodies developed, proximate samples were assayed for viral load by polymer

240 d model deprived of behavioral feedstock and proximate selective drivers capable of triggering the ne

241 Proximate selfish goals reflect the machinations of more

242 to an evolutionarily conserved E-box on the proximate Snail2 promoter to induce its transcription.

243 gs address long-standing questions about the proximate source of human altruism by suggesting that pr

244 garding local air quality impacts related to proximate sources, to provide data in areas lacking regi

245 ference to the temporally and geographically proximate species Au. africanus.

246 That observation is consistent with the proximate stimulus for acid taste being intracellular ac

247 ted food composition studies and tables, the proximate system measures protein as total nitrogen (N)

248 rmation; and (c) identification of potential proximate targets down-stream of the CYGB genes.

249 ation of RVI with CLAD was stronger the more proximate the RVI episode: 4.8 (1.9-11.6), P < .01; 3.4

250 Transcending reviewed proximate theories, Van Lange et al.'s CLASH model attem

251 active Orbitrap mass spectrometers, that the proximate TMT10 reporter ion pairs become prone to coale

252 ilms in which the entire switching volume is proximate to a defective surface.

253 hnique that uses irradiation of chromophores proximate to a target protein to inactivate function.

254 onance experiments show that this species is proximate to Al atoms, similar to the Bronsted acid site

255 hydroxyls on extra-lattice aluminol species proximate to Bronsted lattice sites, i.e., a small popul

256 limiting analyses to variants that are in or proximate to coding regions.

257 de the discovery of exotic superconductivity proximate to conventional spin and charge order, and the

258 On the other hand, PAHs in soils proximate to current Juan Carlos I research station show

259 We used neuropsychological data proximate to death to create summary measures of global

260 en considering number of baseline aPLs, aPLs proximate to death, and persistence of aPLs.

261 who had at least 1 week of wrist actigraphy proximate to death.

262 ociation between APOE genotype and cognition proximate to death.

263 racteristics on global cognitive performance proximate to death.

264 cluding episodic memory function (P < 0.001) proximate to death.

265 ognitive function was evaluated annually and proximate to death.

266 e wobble orientation such that Tg(6) O(2) is proximate to G(19) N1H and Tg(6) N3H is proximate to G(1

267 ) is proximate to G(19) N1H and Tg(6) N3H is proximate to G(19) O(6).

268 n economically relevant traits that are most proximate to known biological mechanisms.

269 iple proteins that associate with and/or are proximate to LaA in vivo.

270 dicates that the naphthalene group of ANS is proximate to Leu105 in the cavity.

271 normal laboratory results and adverse events proximate to MRA initiation.

272 ophyletic group at the base of the Mollusca, proximate to other derived clades such as Cephalopoda, o

273 rts to modulate the change in steroid levels proximate to ovulation merit further study.

274 (CRFR1 Glu104/CRFR2alpha Pro-100) at a site proximate to peptide residue 35 (Arg in CRF/Ucn1, Ala in

275 In the present study, we analyzed tissues proximate to saliva, urine, and fecal production by sPMC

276 residue Gln-57, a residue hypothesized to be proximate to the aryl group of the bound agonist and a p

277 ariants at SLC26A9 (which mediates processes proximate to the CF disease-causing gene) and at four su

278 Proximate to the COOH terminus of the BRCA2 protein, a c

279 hlorophyll-a was greatest at reef ecosystems proximate to the equator and northern-most locations, sh

280 binding pocket formed by K30, K77, and P81, proximate to the hinge region of the N-terminal helix, w

281 dinates 35, -71, 19) and white matter region proximate to the left superior frontal gyrus (Tailerach

282 jor groove and position the aziridinium ions proximate to the major groove edge of the N+2 C.G base p

283 fuel burn-weighted departures on the runway proximate to the monitor, whereas ozone is negatively as

284 perature magnetic order matching predictions proximate to the QSL.

285 the bilateral fornices, white matter region proximate to the right angular gyrus (Tailerach coordina

286 er exclusion of patients who were transfused proximate to the time of rejection.

287 og (AmTRPV4) to be activated at temperatures proximate to the TSD-related temperature in alligators,

288 ormation that allows an ortho hydrogen to be proximate to the two ring oxygens, leading to attractive

289 layers, one-dimensional edge contacts and a proximate top gate configured as microwave ground togeth

290 Positive correlations were found between proximate traits related to taste and antioxidants.

291 quential heating of each muTM stage, while a proximate, underlying thermoelectric cooler provides con

292 mutated, ADAMTS5 cleaves inefficiently at a proximate upstream site but normally does not cleave els

293 It also provided a more proximate variable relating animal distribution to clima

294 Although proximate vegetation is known to be sensed through a red

295 ge tumor development, suggesting that levels proximate (versus distant) to diagnosis may better predi

296 r prolactin levels on samples collected <10 (proximate) versus >/=10 (distant) years before diagnosis

297 sease prevalence in spatially and temporally proximate villages modulates the influences of village-l

298 women with two blood samples (Pinteraction, proximate vs. distant = 0.07).

299 ttern of shared ancestry with geographically proximate wild barley populations.

300 m CO2 emissions of colocated or electrically proximate wind/storage and solar/storage facilities acro