ライフサイエンスコーパス: pseudoephedrine

1 (6), using an amide of the chiral auxiliary pseudoephedrine.

2 edicated with antihistamines, albuterol, and pseudoephedrine.

3 Pseudoephedrine, 30 mg PO, increased SBP on average 52+/

4 and Z-enolates, proposed to be opposite the pseudoephedrine alkoxide side chain.

5 iovascular effects of phenylpropanolamine or pseudoephedrine, alone and in combination with water, we

6 addition of the lithium enolate derived from pseudoephedrine alpha-fluoroacetamide to nitroalkene 12,

7 mplified by alkylation of the diastereomeric pseudoephedrine alpha-methylbutyramides, where both subs

8 Pseudoephedrine alpha-phenylbutyramides are found to und

9 Increasing concentrations of ephedrine and pseudoephedrine also increased the number of intraburst

10 Also, we show that alpha,alpha-disubstituted pseudoephedrine amide enolates can be generated in a hig

11 utcome of the asymmetric Michael reaction of pseudoephedrine amide enolates changes dramatically in t

12 presented to transform the alpha-quaternary pseudoephedrine amide products into optically active car

13 rect alkylation of alpha,alpha-disubstituted pseudoephedrine amide substrates is demonstrated to be b

14 mer of an alpha-alkyl-alpha,beta-unsaturated pseudoephedrine amide, providing alpha,alpha-disubstitut

15 Immobilized pseudoephedrine amides are conveniently prepared by the

16 ion of alpha,alpha-disubstituted enolates of pseudoephedrine amides are presented followed by the imp

17 ggered by electrophilic activation of chiral pseudoephedrine amides.

18 amine, MDMA, MDA), ephedrines (ephedrine and pseudoephedrine), antidepressant venlafaxine, and beta-b

19 Ephedrine and pseudoephedrine are stimulant drugs whose use is prohibi

20 base of N'-aryl urea derivatives ligated to pseudoephedrine as a chiral auxiliary.

21 rful and flexible asymmetric synthesis using pseudoephedrine as a chiral auxiliary.

22 carboxylic acid derivatives using (S,S)-(+)-pseudoephedrine as chiral auxiliary, making use of the s

23 Pseudoephedrine-based [1,3,4]-oxadiazinan-2-ones acylate

24 nolamine has been largely substituted for by pseudoephedrine, but it is not clear whether this is ind

25 used to produce the precursors ephedrine and pseudoephedrine by measurement of stable isotope ratios

26 1.5, 95% confidence interval: 1.1, 2.2), and pseudoephedrine combined with acetaminophen (odds ratio

27 hown here that chlorination of the ephedrine/pseudoephedrine compounds occurs via inversion (S(N)2) a

28 for simultaneous separation of ephedrine and pseudoephedrine containing multiple chiral centers and t

29 in the presence of a chiral inductor such as pseudoephedrine, ee's up to 28% have been obtained.

30 mation via the chlorination of ephedrine and pseudoephedrine enantiomers.

31 e (group 2), 60 mg of fexofenadine/120 mg of pseudoephedrine (group 3), and placebo (group 4).

32 Although pseudoephedrine has previously been shown to increase ga

33 ynthesized from either from l-ephedrine or d-pseudoephedrine hydrochloride in reactions which were al

34 hetamine hydrochloride from l-ephedrine or d-pseudoephedrine hydrochloride via reduction with hydriod

35 onfidence interval: 1.0, 4.0) and for use of pseudoephedrine in combination with acetaminophen (odds

36 s developed for one of the PEAs (e.g., (+/-)-pseudoephedrine) in human urine.

37 even model drugs (atenolol, DOPA, ephedrine, pseudoephedrine, isoproterenol, norepinephrine, proprano

38 sal symptom scoring; however, in contrast to pseudoephedrine, it only showed a trend for increasing n

39 square mean difference, -0.126; P = .06) and pseudoephedrine (least square mean difference, -0.195; P

40 he channel blocking effects of ephedrine and pseudoephedrine might reduce the synaptic overactivity t

41 o = 2.7, 95% confidence interval: 1.2, 5.9), pseudoephedrine (odds ratio = 1.8, 95% confidence interv

42 Risks of SIA were increased for any use of pseudoephedrine (odds ratio = 2.0, 95% confidence interv

43 r all scores) compared with placebo, whereas pseudoephedrine only showed a trend for improvement in i

44 ic syndromes respond favorably to ephedrine, pseudoephedrine, or albuterol.

45 d to JNJ-39220675 plus placebo, placebo plus pseudoephedrine, or only placebo.

46 tly smaller for JNJ-39220675 (P = .0003) and pseudoephedrine (P = .04) versus placebo.

47 zed from commercially available (+)- and (-)-pseudoephedrine propionamide in 6 steps and 59% average

48 Finally, the pseudoephedrine resin can be conveniently recycled and u

49 A pseudoephedrine resin has been successfully employed in

50 f linking the intermediates to the ephedrine/pseudoephedrine starting materials.

51 ently prepared by the one-step attachment of pseudoephedrine to Merrifield resin through the hydroxyl

52 of interview responses (e.g., start month of pseudoephedrine use).

53 ten prepared from the precursor ephedrine or pseudoephedrine, which in turn are obtained by three pro