ライフサイエンスコーパス: pseudohyphal

1 The IH switched between pseudohyphal and filamentous growth.

2 ogical transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells attac

3 tches between growth as budding yeast and as pseudohyphal and hyphal filaments in host organs and in

4 sible morphological transition from yeast to pseudohyphal and hyphal filaments, which is required for

5 nd in significantly greater numbers than did pseudohyphal and hyphal forms, respectively, contrasting

6 e morphogenetic transitions between budding, pseudohyphal and hyphal growth forms that promote the vi

7 gulatory mechanisms that determine growth in pseudohyphal and hyphal morphologies are largely unknown

8 gulatory mechanism functions to specify both pseudohyphal and hyphal morphologies in a dosage-depende

9 thways in yeast, including those involved in pseudohyphal and invasive growth, as well as mating.

10 Deletion of SFL1 enhances pseudohyphal and invasive growth.

11 vidence concerning the role played by yeast, pseudohyphal, and hyphal forms of C. albicans in adhesio

12 The ability to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is

13 east budding pathway, we used enhancement of pseudohyphal budding in S. cerevisiae by human proteins

14 medium and demonstrated a propensity to form pseudohyphal cells on prolonged culture in vitro and in

15 n a ring at the mother-bud neck of yeast and pseudohyphal cells.

16 cerevisiae, S. mikatae, and S. bayanus under pseudohyphal conditions.

17 ound only in S. mikatae and S. bayanus under pseudohyphal conditions.

18 dding cells, was also able to complement the pseudohyphal defect characteristic of the mutant yeast.

19 The pseudohyphal defect of Deltamep2/Deltamep2 strains was s

20 t or exogenous cAMP suppresses the Deltagpa2 pseudohyphal defect.

21 ationship between sporulation efficiency and pseudohyphal development and correlates with variation i

22 Activated alleles of RAS2 and CDC42 induce pseudohyphal development and FG(TyA)-lacZ signaling in B

23 n1 cln2 double mutants are more defective in pseudohyphal development and haploid invasive growth tha

24 quired for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae.

25 ed the transcriptional circuitry controlling pseudohyphal development in Saccharomyces cerevisiae.

26 mentous fungus Aspergillus nidulans, induces pseudohyphal development in the yeast Saccharomyces cere

27 Flo11, a cell surface flocculin required for pseudohyphal development, is transcriptionally regulated

28 nents controls mating, haploid invasion, and pseudohyphal development.

29 ons in a positive feedback loop required for pseudohyphal development.

30 ctions in co-operation with STE12p to induce pseudohyphal development.

31 Mos10 is limited to the maturation stage of pseudohyphal development.

32 at they have dramatically different roles in pseudohyphal development: Tpk2 is essential, whereas Tpk

33 ascade signaling, but they are essential for pseudohyphal-development MAPK cascade signaling and othe

34 genic pathways for which Ste20 is essential, pseudohyphal differentiation and haploid-invasive growth

35 The tap42-11 mutation compromised pseudohyphal differentiation and rendered it resistant t

36 he nitrogen sensing machinery that regulates pseudohyphal differentiation by modulating cAMP levels.

37 affinity ammonium permease, is required for pseudohyphal differentiation in response to ammonium lim

38 Pseudohyphal differentiation in the budding yeast Saccha

39 Our findings support a model in which pseudohyphal differentiation is controlled by a nutrient

40 that the mutant tRNA(CUG)(Gln) constitutive pseudohyphal differentiation phenotype correlates strong

41 However, Swe1 is essential for pseudohyphal differentiation under a number of nonstanda

42 Pseudohyphal differentiation, a filamentous growth form

43 selecting a developmental program--budding, pseudohyphal differentiation, quiescence or sporulation-

44 glucose sensitive, but also affected diploid pseudohyphal differentiation, thereby unexpectedly impli

45 factor Sok2 was found to negatively regulate pseudohyphal differentiation.

46 ntiate to a filamentous growth form known as pseudohyphal differentiation.

47 kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation.

48 n alpha subunit homologs in yeast, regulates pseudohyphal differentiation.

49 es including metabolism, stress response and pseudohyphal differentiation.

50 ap42-regulated phosphatases had no effect on pseudohyphal differentiation.

51 gen starvation or growth on solid medium for pseudohyphal differentiation.

52 and oval cells surrounding and covering the pseudohyphal filament.

53 ays a critical and tightly regulated role in pseudohyphal filamentation.

54 We report here that rapamycin inhibits pseudohyphal filamentous differentiation of S. cerevisia

55 gen deprivation, wherein yeast colonies form pseudohyphal filaments of elongated and connected cells.

56 a role in invasive disease: while hyphal and pseudohyphal filaments penetrate host cells and tissues,

57 ein cells elongate and interconnect, forming pseudohyphal filaments.

58 when FLO11 is expressed, diploid cells form pseudohyphal filaments; when FLO11 is silent, the cells

59 ME6 expression specify growth largely in the pseudohyphal form and that increasing UME6 levels is suf

60 MNL-mediated fungicidal activity against the pseudohyphal form of C. albicans, thereby suggesting pot

61 east organism, both phenotypic switching and pseudohyphal formation have recently been identified in

62 phal growth on UFA-supplemented medium agar, pseudohyphal formation in the OLE1 KO cells was severely

63 Mutants deficient in pseudohyphal formation were tested in vivo; flo11Delta m

64 ective in nitrogen signaling associated with pseudohyphal formation, sporulation, and NCR.

65 encodes a cell surface protein required for pseudohyphal formation.

66 c switching from the yeast to the hyphal and pseudohyphal forms under certain conditions.

67 Over the last 15 years, yeast pseudohyphal growth (PHG) has been the focus of intense

68 They were also defective for pseudohyphal growth and agar invasion, and displayed red

69 n of the UPR, and subsequent derepression of pseudohyphal growth and meiosis.

70 by the UPR, was sufficient for repression of pseudohyphal growth and meiosis.

71 An activated UPR then represses pseudohyphal growth and meiosis.

72 yclin, prevented fkh1Delta fkh2Delta-induced pseudohyphal growth and modulated some of the fkhDelta-i

73 ing were isolated from an alpha strain using pseudohyphal growth as an assay.

74 egions of the previously known regulators of pseudohyphal growth as well as those of many additional

75 Here, we address the genetic basis of yeast pseudohyphal growth by implementing a systematic analysi

76 gulated protein phosphatase Sit4 exhibited a pseudohyphal growth defect and were markedly hypersensit

77 MEP2 expression or stability, also conferred pseudohyphal growth defects.

78 Finally, we have found that pseudohyphal growth exhibited by wild-type (HOG1) strain

79 m, but eliminated their abilities to provide pseudohyphal growth for the S. cerevisiae triple mutant.

80 cerevisiae differentiate into a filamentous, pseudohyphal growth form.

81 cerevisiae differentiate into a filamentous, pseudohyphal growth form.

82 r-daughter cell junction distinguishes yeast/pseudohyphal growth from hyphal growth in C. albicans.

83 volve processes related to those controlling pseudohyphal growth in budding yeast.

84 of a Gbetagamma dimer to negatively regulate pseudohyphal growth in budding yeast.

85 ein phosphatase regulatory subunit, restored pseudohyphal growth in cells exposed to rapamycin.

86 This defect in FLO8 blocks pseudohyphal growth in diploids, haploid invasive growth

87 Unlike pseudohyphal growth in Saccharomyces cerevisiae, hyphal

88 c subfamily (Cph2) by its ability to promote pseudohyphal growth in Saccharomyces cerevisiae.

89 Swe1 is also required for pseudohyphal growth in the absence of Tec1 and for the i

90 s MEP genes capable of efficiently restoring pseudohyphal growth in yeast.

91 Pseudohyphal growth is a developmental pathway seen in s

92 Our findings reveal that pseudohyphal growth is controlled by the calcineurin sig

93 r all conditions tested, its contribution to pseudohyphal growth is limited to the morphological resp

94 the known role of the MAP kinase pathway in pseudohyphal growth is linked to Mep2 function.

95 tinct from the nutritionally induced form of pseudohyphal growth observed in some strains of S. cerev

96 Our data confirm that pseudohyphal growth occurs gratuitously in sup70-65 muta

97 PCSTE20), a gene participating in mating and pseudohyphal growth of other fungi, was identified follo

98 Early pseudohyphal growth of Saccharomyces cerevisiae is well

99 has, to a large extent, come from studies of pseudohyphal growth of the model organism Saccharomyces

100 A mutant allele, sup70-65, induces pseudohyphal growth on rich medium, an inappropriate nit

101 to wild-type C. parapsilosis, which produced pseudohyphal growth on UFA-supplemented medium agar, pse

102 Sho1p may be a receptor that feeds into the pseudohyphal growth pathway.

103 see text] sup70-65 mutant, which exhibits a pseudohyphal growth phenotype and a 75% slower CAG codon

104 up70-65 background, and ameliorated sup70-65 pseudohyphal growth phenotypes.

105 Classic studies have identified core pseudohyphal growth signaling modules in yeast; however,

106 r of these two proteins specifically induced pseudohyphal growth under noninducing conditions, highli

107 a model in which the Gpr1 receptor regulates pseudohyphal growth via the Gpa2p-cAMP-PKA pathway and i

108 Pseudohyphal growth was derepressed in ire1Delta/ire1Del

109 everal criteria, fkh1Delta fkh2Delta-induced pseudohyphal growth was distinct from the nutritionally

110 calcineurin, are required for C. lusitaniae pseudohyphal growth, a process for which the underlying

111 rmease Mep2 is required for the induction of pseudohyphal growth, a process in Saccharomyces cerevisi

112 Mep2 is localized to the cell surface during pseudohyphal growth, and it is required for both filamen

113 rentiation responses to nitrogen starvation, pseudohyphal growth, and meiosis.

114 s yeast genes affecting nitrogen catabolism, pseudohyphal growth, and meiotic sporulation.

115 programs in response to nitrogen starvation, pseudohyphal growth, and sporulation.

116 ot preclude an sla2-6 mutant from undergoing pseudohyphal growth, highlighting the central role of da

117 ile of differential protein abundance during pseudohyphal growth, identifying a previously uncharacte

118 PKA signals pseudohyphal growth, in part, by regulating Flo8-depende

119 logue in yeast, FKH2, caused a form of yeast pseudohyphal growth, indicating that the two genes have

120 uolar degradation, results in abnormal early pseudohyphal growth, not in the filament maturation defe

121 We identified TF targets relevant for pseudohyphal growth, producing a detailed map of its reg

122 ulence attributes of C. lusitaniae including pseudohyphal growth, serum survival, and growth at 37 de

123 However, none conferred pseudohyphal growth, showing altered CUG anticodon prese

124 h FKH2 is redundant with FKH1 in controlling pseudohyphal growth, the two genes have different functi

125 abundant at the yeast cell periphery during pseudohyphal growth, we generated quantitative proteomic

126 ergoes a dimorphic transition to filamentous pseudohyphal growth.

127 Tpk2, but not Tpk1 or Tpk3, is required for pseudohyphal growth.

128 of the osmoresponsive MAPK Hog1p may enhance pseudohyphal growth.

129 ndergo a dimorphic transition to filamentous pseudohyphal growth.

130 of Mks1p or deletion of MKS1 interferes with pseudohyphal growth.

131 c regulator that we show to be essential for pseudohyphal growth.

132 n promotes the initiation of sporulation and pseudohyphal growth.

133 a2/Deltagpa2 mutant strains have a defect in pseudohyphal growth.

134 anticodon presentation cannot itself induce pseudohyphal growth.

135 aughter cell-specific function necessary for pseudohyphal growth.

136 ed morphogenesis during budding, mating, and pseudohyphal growth.

137 here that Ash1 has an essential function for pseudohyphal growth.

138 lized to the nuclei of daughter cells during pseudohyphal growth.

139 tationary phase but opt for pathways such as pseudohyphal growth.

140 of a morphological transition, in this case pseudohyphal growth.

141 sly been shown to respond to IAA by inducing pseudohyphal growth.

142 increased expression of a gene required for pseudohyphal growth.

143 CSTE20 suppressed defects in both mating and pseudohyphal growth.

144 with a role for nuclear Hog1p in repressing pseudohyphal growth.

145 logical changes similar to those seen during pseudohyphal growth.

146 t exhibited a constitutive polarized mode of pseudohyphal growth.

147 and transcriptional outputs regulating yeast pseudohyphal growth.

148 cluding hyperpolarization and enhancement of pseudohyphal growth.

149 veal crosstalk between these pathways during pseudohyphal growth.

150 that its dynamics are distinct from that of pseudohyphal growth; during pheromone-induced filament f

151 y, the three A kinases are not redundant for pseudohyphal growth; Tpk2, but not Tpk1 or Tpk3, is requ

152 is sufficient to drive the C. albicans yeast-pseudohyphal-hyphal transition.

153 transition from the normal yeast form to the pseudohyphal, invasive form.

154 rity glycerol (HOG), pheromone response, and pseudohyphal/invasive growth pathways], but its activati

155 cellular signals: mating-pheromone response, pseudohyphal/invasive growth, cell wall integrity, and h

156 Our data suggest that the differentiation of pseudohyphal-like sterigmatal cells during multicellular

157 and changes in budding pattern, leading to a pseudohyphal morphology, even in liquid medium.

158 the fkh1 fkh2 mutant displays a constitutive pseudohyphal morphology, indicating that Fkh1 and Fkh2 m

159 myces cerevisiae that plays a direct role in pseudohyphal or filamentous growth for that organism.

160 c switching and to produce wrinkled (WR) and pseudohyphal (PH) colony types at frequencies of approxi

161 imorphic and switches from a yeast form to a pseudohyphal (PH) form when starved for nitrogen.

162 ific gene expression required for mating and pseudohyphal (PH)/filamentous growth (FG).

163 In addition, the sup70-65 pseudohyphal phenotype was partly complemented by overex

164 To investigate the basis of the pseudohyphal phenotype, 10 novel sup70 UAG suppressor al

165 young cells differ significantly from their pseudohyphal progenitors, in their shape, and in their t

166 , the divergence in the binding sites of the pseudohyphal regulators Ste12 and Tec1 was determined in

167 l intracellular loop of MEP2 involved in the pseudohyphal regulatory function.

168 cient to cause cells to gradually shift from pseudohyphal to hyphal morphology.

169 2), suggesting that Cln1,2/Cdks regulate the pseudohyphal transcriptional program.

170 on are separable processes controlled by the pseudohyphal transcriptional program.

171 species overexpression approach, we used the pseudohyphal transition of Saccharomyces cerevisiae as a

172 central to both the mating response and the pseudohyphal transition.

173 al profile of the C. albicans reverse hyphal-pseudohyphal-yeast transition and demonstrate that this