ライフサイエンスコーパス: pseudouridine synthase

1 4, an uncharacterized mitochondrial putative pseudouridine synthase.

2 morphic alleles of nop60B, a gene encoding a pseudouridine synthase.

3 id residue is catalytically essential in one pseudouridine synthase.

4 antly alter the catalytic activity of either pseudouridine synthase.

5 uridine (or pseudouridylation) catalyzed by pseudouridine synthases.

6 ends on both site-specific and snoRNA-guided pseudouridine synthases.

7 ficant relative to turnover by the wild-type pseudouridine synthases.

8 to these previously identified ribosomal RNA pseudouridine synthases.

9 Pseudouridine synthase 1 (Pus1p) is an unusual site-spec

10 The PUS1 gene encodes the enzyme pseudouridine synthase 1 (Pus1p) that is known to pseudo

11 tified a homozygous missense mutation in the pseudouridine synthase 1 gene (PUS1) in all patients wit

12 A cDNA encoding mouse pseudouridine synthase 3 (mPus3p) has been cloned.

13 redicted protein has 34% identity with yeast pseudouridine synthase 3 (Pus3), an enzyme known to form

14 Pseudouridine Synthase 4 (Pus4) and the Actin Patch Prot

15 in the ribosomal protein S4, two families of pseudouridine synthases, a novel family of predicted RNA

16 oned, overexpressed, and shown to code for a pseudouridine synthase able to react with in vitro trans

17 de that the conserved Asp60 is essential for pseudouridine synthase activity and propose mechanisms w

18 r novel domain, designated PUA domain, after PseudoUridine synthase and Archaeosine transglycosylase,

19 rate bound to the ribonucleoprotein particle pseudouridine synthase and enzyme activity assay confirm

20 ery similar to the catalytic domain of other pseudouridine synthases and a second large domain (149 a

21 tural properties that are unique among known pseudouridine synthases and are consistent with its dist

22 he downstream genes ppnK (NAD kinase), rluE (pseudouridine synthase), and pta (phosphotransacetylase)

23 Dyskerin is a putative pseudouridine synthase, and it has been suggested that D

24 roteins, including ribosomal protein S4, RNA pseudouridine synthase, and tyrosyl-tRNA synthetase.

25 ase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases,

26 Ten methyltransferases and one pseudouridine synthase are required for complete modific

27 Nine methyltransferases, as well as the pseudouridine synthase, are already known.

28 roline residues in Motif I of RluA and TruB, pseudouridine synthases belonging to different families.

29 The pseudouridine synthases catalyze the isomerization of ur

30 The pseudouridine synthases catalyze the isomerization of ur

31 ific H/ACA RNA and four common proteins, the pseudouridine synthase Cbf5, Nop10, Gar1, and Nhp2.

32 The pseudouridine synthase, Cbf5, is also the protein that s

33 A guide RNA and four proteins, including the pseudouridine synthase, Cbf5.

34 stand alone pseudouridine synthases, the RNP pseudouridine synthase comprises multiple protein subuni

35 e, TERC, and other components, including the pseudouridine synthase, dyskerin, the product of the DKC

36 ight of the global dissimilarity between the pseudouridine synthase families, we changed the aspartic

37 ture of the RNA-modifying enzyme, psi55 tRNA pseudouridine synthase from Mycobacterium tuberculosis,

38 ue is critical for the catalytic activity of pseudouridine synthases from two additional families of

39 of macrophages with a F. tularensis LVS rluD pseudouridine synthase (FTL_0699) mutant resulted in dim

40 our findings also support the assignment of pseudouridine synthase function to certain physiological

41 tic acid residue might be a prerequisite for pseudouridine synthase function.

42 tRNA pseudouridine synthase I (PsiSI) catalyzes the conversio

43 Escherichia coli tRNA pseudouridine synthase I (PSUI) catalyzes the conversion

44 tRNA caused a time-dependent inactivation of pseudouridine synthase I and formed a covalent complex w

45 tRNA pseudouridine synthase I catalyzes the conversion of uri

46 Pseudouridine synthase I was cloned behind a T7 promoter

47 de a resource for identifying the targets of pseudouridine synthases implicated in human disease.

48 TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsib

49 s little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have

50 The pseudouridine synthases isomerize (U) in RNA to pseudour

51 Analysis of total tRNA isolated from E. coli pseudouridine synthase knock-out mutants identified RluF

52 guide RNA and four essential proteins: Cbf5 (pseudouridine synthase), L7Ae, Gar1 and Nop10 in archaea

53 e alignments using the first four identified pseudouridine synthases led Koonin and, independently, S

54 pseudouridine synthases (PUS) uncovers which pseudouridine synthase modifies each site and their targ

55 e caused by mostly missense mutations in the pseudouridine synthase NAP57 (dyskerin/Cbf5).

56 ry to probe the role of cysteine residues in pseudouridine synthases of the families that do not incl

57 ence and structural comparisons suggest that pseudouridine synthases of the RluA, RsuA, and TruA fami

58 The predicted SwoCp is homologous to rRNA pseudouridine synthases of yeast (Cbf5p) and humans (Dkc

59 f the TruA, TruB, RsuA, and RluA families of pseudouridine synthases (PsiS) identifies a strictly con

60 tructural comparisons with other families of pseudouridine synthases (PsiS) indicate that Psi55S may

61 We identified a pseudouridine synthase (PUS), mPus1p, as a coactivator f

62 Perturbing pseudouridine synthases (PUS) uncovers which pseudouridi

63 modification sites to one of seven conserved pseudouridine synthases, Pus1-4, 6, 7 and 9.

64 The rluC gene encodes a pseudouridine synthase responsible for pseudouridine mod

65 The Escherichia coli rluD gene encodes a pseudouridine synthase responsible for the pseudouridine

66 e Escherichia coli gene rluA, coding for the pseudouridine synthase RluA that forms 23 S rRNA pseudou

67 Pseudouridine synthase RluE modifies U2457 in a stem of

68 Escherichia coli pseudouridine synthase RluF is dedicated to modifying U2

69 idine, bound to a ribonucleoprotein particle pseudouridine synthase, strongly prefer the syn glycosid

70 The DKC1 gene encodes a pseudouridine synthase that modifies ribosomal RNA (rRNA

71 Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates

72 n that there are four distinct "families" of pseudouridine synthases that share no statistically sign

73 an active site cleft, conserved in all other pseudouridine synthases, that contains invariant Asp and

74 Different from stand alone pseudouridine synthases, the RNP pseudouridine synthase

75 ar ribonucleoprotein complexes and acts as a pseudouridine synthase to modify newly synthesized ribos

76 Such a role for cysteine in the pseudouridine synthase TruA (also named Psi synthase I)

77 icodon stem loop (ASL) by a highly conserved pseudouridine synthase TruA.

78 The pseudouridine synthase TruB handles 5-fluorouridine in R

79 we prove the tRNA chaperone activity of the pseudouridine synthase TruB, reveal its molecular mechan

80 in the tRNA TPsiC arm by the bacterial tRNA pseudouridine synthase TruB.

81 RNA pseudouridine synthase, TruB, catalyzes pseudouridine fo

82 Asp60, conserved in all known and putative pseudouridine synthases, was mutated to amino acids with

83 On the basis of sequence alignments, the pseudouridine synthases were grouped into four families