ライフサイエンスコーパス: psychiatric

1 Psychiatric adverse events were the most common in both

2 Cognitive deficits in psychiatric and age-related disorders generally involve

3 CHRNA7 gene, has been implicated in various psychiatric and behavioral disorders, including schizoph

4 of inflammation on motivational behavior in psychiatric and chronic illnesses.

5 pulation-based sample, and matched for other psychiatric and cognitive dimensions.

6 ce intervals were estimated with control for psychiatric and medical conditions, medications, and oth

7 frequently lethal disorder as one with both psychiatric and metabolic etiology.

8 esis or manifestation of neurodevelopmental, psychiatric and neurodegenerative diseases, such as auti

9 In psychiatric and neurodegenerative disorders, therapeutic

10 rk dysfunction is at the core of a number of psychiatric and neurodegenerative disorders.

11 ne neuron dysfunction contributes to various psychiatric and neurological diseases, including drug ad

12 NMDA receptors are also implicated in psychiatric and neurological disorders and have received

13 ula and underscore its pathological roles in psychiatric and neurological disorders that have long be

14 cognitive impairment observed in a number of psychiatric and neurological disorders, such as schizoph

15 ation is a characteristic feature of several psychiatric and neurological disorders.

16 ctivation is implicated in a number of human psychiatric and neurological illnesses.

17 ntrol to the known etiological mechanisms of psychiatric and neurological synaptopathies.

18 nferroni biomarkers for involvement in other psychiatric and non-psychiatric disorders, as a mechanis

19 What makes the molecular study of psychiatric and other neurological conditions particular

20 pressed patients frequently suffer from both psychiatric and somatic comorbid disorders.

21 ies; expansion of integrated care to address psychiatric and substance use comorbidities; and electro

22 Demographic, psychiatric, and biochemical variables at admission and

23 application has transformative potential for psychiatric approaches of the millennium.

24 completed a battery of behavioral measures, psychiatric assessment, and resting-state functional mag

25 designed studies incorporating comprehensive psychiatric assessments, randomization, objective docume

26 : Rates of compulsory admission to inpatient psychiatric beds vary significantly between local areas

27 Individuals discharged from inpatient psychiatric care at least once before their 15th birthda

28 and computational techniques to help improve psychiatric care.

29 information about hospital contacts from the Psychiatric Central Research Register and deaths from th

30 The Danish Psychiatric Central Research Register ascertained schizo

31 d from the Danish Civil Registration System, Psychiatric Central Research Register, and Register of C

32 the Danish Civil Registration System and the Psychiatric Central Research Register.

33 f clinical phenotypes dominated by dementia, psychiatric changes, movement disorders and upper motor

34 e to gender differences and to the impact of psychiatric co-morbidities and medications.

35 After adjusting for psychiatric comorbidities, the risk was reduced but rema

36 risk remains substantial after adjusting for psychiatric comorbidities.

37 Psychiatric comorbidity complicates clinical care and co

38 Q fever infection, without other somatic or psychiatric comorbidity explaining the fatigue.

39 s with TD/CTD, establish the contribution of psychiatric comorbidity to this risk, and identify predi

40 Hispanic ethnicity, bonded release, and psychiatric comorbidity were also associated with LTC wi

41 issues, several individual risk factors for psychiatric comorbidity, and current research on the und

42 was associated with increased endorsement of psychiatric complaints, but not with objective cognitive

43 order (PMDD), a common, recently recognized, psychiatric condition among women, reflect abnormal resp

44 jor depressive disorder (MDD) is a prevalent psychiatric condition with limited therapeutic options b

45 ses were conducted to quantify the impact of psychiatric conditions (posttraumatic stress disorder, d

46 Smokers with psychiatric conditions and socioeconomic disadvantage ar

47 struct that is characteristic of medical and psychiatric conditions such as forms of obesity and eati

48 ses revealed that medication use, medical or psychiatric conditions, case-control vs longitudinal stu

49 A number of psychiatric conditions, including attention deficit hype

50 fusion and has been associated with multiple psychiatric conditions, including schizophrenia, bipolar

51 y D2R blockers when used in neurological and psychiatric conditions, including schizophrenia, bipolar

52 cits in cognition are a core feature of many psychiatric conditions, including schizophrenia, where t

53 and amygdala are thought to underlie several psychiatric conditions, many related to reward learning.

54 e of the most common, burdensome, and costly psychiatric conditions-is characterized by repeated inte

55 signaling in the maintenance of these unique psychiatric conditions.

56 to first-in-man trials for the treatment of psychiatric conditions.

57 nitive processes known to be impaired across psychiatric conditions.

58 aging and various neurological, medical, and psychiatric conditions.

59 mon among AD individuals, but do not lead to psychiatric consultations, hospitalization, or suicide.

60 whole-exome gene and exon expression in non-psychiatric controls (CON, N=29), DSM-IV major depressiv

61 are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts

62 ncluding 26628 participants with established psychiatric diagnoses and genome-wide genotype data.

63 ernal sera, and to relate them to subsequent psychiatric diagnoses in the woman or her child.

64 ciated with a 22q11.2 deletion, and parental psychiatric diagnoses other than schizophrenia were asso

65 ort study of all women in Denmark who had no psychiatric diagnoses, antidepressant use, or hormonal c

66 diagnosis of schizophrenia-but not of other psychiatric diagnoses-was associated with a 22q11.2 dele

67 mpairment on psychosocial questionnaires and psychiatric diagnoses.

68 sis, and excluded participants with comorbid psychiatric diagnoses.

69 r instance, findings that help corroborate a psychiatric diagnosis, and findings that indicate import

70 a paradigm shift in the conceptualization of psychiatric diagnosis, from symptom-based syndromes, pop

71 of hazardous alcohol use, and 57% a comorbid psychiatric diagnosis.

72 Among the psychiatric diagnostic categories assessed, psychoactive

73 therapeutics indicated for the treatment of psychiatric disease (IRR = 3.78; 95% CI, 1.77-8.06; P <

74 al neurogenesis and contribute to aspects of psychiatric disease through abnormal production of D-ser

75 many to speculate that concurrent delirium, psychiatric disease, dementia, or a second lesion is req

76 uding noncoding RNAs that may play a role in psychiatric disease.

77 ts, which may contribute to neurological and psychiatric disease.

78 Effective drug treatments for many psychiatric diseases are lacking, and the emerging tools

79 DBS to rodent models.SIGNIFICANCE STATEMENT Psychiatric diseases are linked to abnormalities in spec

80 gy and treatment of diverse neurological and psychiatric diseases that are characterized by altered o

81 ponses are linked to a number of somatic and psychiatric diseases, emphasizing the importance of prec

82 novo mutations of NMDAR subunits and severe psychiatric diseases, little is known about their pathog

83 ess has a crucial role in the development of psychiatric diseases, such as anxiety and depression.

84 plied to alcohol use disorder (AUD) or other psychiatric diseases, where there is a critical need for

85 festations of several neurodevelopmental and psychiatric diseases.

86 onsequently, to further our understanding of psychiatric diseases.

87 anders, excluding those diagnosed with these psychiatric diseases.

88 hich contributes to various neurological and psychiatric diseases.

89 ground in how we untangle the complexity of psychiatric diseases; by making thalamic circuits access

90 is involved in a variety of neurological and psychiatric diseases; however, the mechanistic link betw

91 Depression in older adults is a common psychiatric disorder affecting their health-related qual

92 tempts across levels of sociodemographic and psychiatric disorder groups.

93 nfections have an increased vulnerability to psychiatric disorder later in life, and this should be t

94 Anorexia nervosa is a psychiatric disorder of unknown etiology.

95 Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippoc

96 suicide attempts across sociodemographic and psychiatric disorder strata.

97 Mean (SD) age at diagnosis of any psychiatric disorder was 12.5 (8.3) years for individual

98 tic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime prevalence of nearl

99 ia activation has been noted in all types of psychiatric disorder, no association was seen with speci

100 ogical contributions to the etiology of this psychiatric disorder, which appears to be rising in some

101 Controls had no Axis I psychiatric disorder.

102 ations between these subregions and specific psychiatric disorders (depression, posttraumatic stress

103 eported in seven (25%) patients and included psychiatric disorders (six events in four patients), gai

104 We also describe how therapeutics used for psychiatric disorders act on the purinergic system.

105 eal a high rate of complex cases (25%), with psychiatric disorders among the most common comorbidity

106 precipitate the onset of a broad spectrum of psychiatric disorders and addiction in adulthood.

107 s, associated with cardiometabolic diseases, psychiatric disorders and all-cause mortality, affect 25

108 seven serious adverse events categorised as psychiatric disorders and as gait disturbance were asses

109 Anhedonia is central to multiple psychiatric disorders and causes substantial disability.

110 act of inflammation on the brain cuts across psychiatric disorders and engages dopaminergic and gluta

111 n provide important biological insights into psychiatric disorders and may consequently have direct c

112 To examine how smokers with psychiatric disorders and other vulnerabilities to tobac

113 Psychiatric disorders are debilitating diseases, affecti

114 However, psychiatric disorders are highly multifactorial with a w

115 s can precipitate or worsen symptoms of many psychiatric disorders by dysregulating glutamatergic fun

116 proach to using ketamine in the treatment of psychiatric disorders considering the limited informatio

117 ntelligence, few population-based studies of psychiatric disorders have assessed intelligence.

118 The complexity and genetic heterogeneity of psychiatric disorders have challenged the development of

119 may play a critical role in the emergence of psychiatric disorders in adolescence.

120 nce rate ratios (IRRs) and absolute risk for psychiatric disorders in clinically identified individua

121 lammation and diabetes increase the risk for psychiatric disorders in offspring.

122 y challenging to diagnose and treat the many psychiatric disorders in which serotonin is implicated.

123 e manifestation of endophenotypes related to psychiatric disorders including cognitive decline, impai

124 The neurobiology of psychiatric disorders is still unclear, although changes

125 Psychiatric disorders such as addiction and mania are ma

126 ese are currently targeted in the context of psychiatric disorders such as autism and schizophrenia,

127 for normal brain function and is altered in psychiatric disorders such as autism.

128 anslational relevance for neurodevelopmental psychiatric disorders such as schizophrenia.

129 urthermore, deep-brain stimulation (DBS) for psychiatric disorders targets these fibers.

130 have been studied in relation to suicide and psychiatric disorders that increase the risk of suicide

131 dequately controlled for depression or other psychiatric disorders that may be linked with insomnia.

132 The persistence of common, heritable psychiatric disorders that reduce reproductive fitness i

133 Psychiatric disorders were assessed by a structured inte

134 IN abnormalities are linked to two pediatric psychiatric disorders with high comorbidity: autism spec

135 long-standing interest in the association of psychiatric disorders with intelligence, few population-

136 d both well-known (e.g., substance abuse and psychiatric disorders) and less conventional (e.g., cert

137 ining microglial activation in patients with psychiatric disorders, and explore the relevance of thes

138 r higher) with no history of neurological or psychiatric disorders, and had completed amyloid imaging

139 gly, Hb dysfunction has been associated with psychiatric disorders, and studies in patients have esta

140 mber variations (CNVs) are linked to several psychiatric disorders, and to synaptic and behavioral de

141 for involvement in other psychiatric and non-psychiatric disorders, as a mechanism for biological pre

142 formance and educational attainment, several psychiatric disorders, birth length/weight and smoking b

143 predicted to be damaging were performed for psychiatric disorders, cognitive variables and personali

144 uid intelligence with past-year and lifetime psychiatric disorders, disorder age at onset, and disord

145 c dimension separated personality traits and psychiatric disorders, except that neuroticism and openn

146 th the genetic risk architecture for several psychiatric disorders, fueling PsychENCODE and other lar

147 The familial coaggregation of other psychiatric disorders, in particular schizophrenia, show

148 ests abnormalities in brain bioenergetics in psychiatric disorders, including both bipolar disorder (

149 ible implication in several neurological and psychiatric disorders, including cognitive decline assoc

150 e was associated with pathways implicated in psychiatric disorders, including dopamine neuron differe

151 (ACC) cortices has been linked with several psychiatric disorders, including obsessive-compulsive di

152 itive and affective processing as well as in psychiatric disorders, including schizophrenia, depressi

153 ve an increased genetic risk for three major psychiatric disorders, suggesting that it is useful to c

154 sequencing of patients with neurological or psychiatric disorders, we investigated missense variants

155 gly studied for its therapeutic potential in psychiatric disorders, which are associated with the der

156 k-taking and impulsivity-common behaviors in psychiatric disorders-and provides a novel framework for

157 ch is implicated as dysfunctional in various psychiatric disorders-toward enhanced synthesis of kynur

158 ns in CNTN4 gene have been linked to various psychiatric disorders.

159 oth animal research and the context of human psychiatric disorders.

160 ovel target to develop therapeutics to treat psychiatric disorders.

161 disorder, PVI circuits are altered in these psychiatric disorders.

162 relevance and translation of these tasks in psychiatric disorders.

163 and can be harnessed to shed a new light on psychiatric disorders.

164 ssociated with a variety of neurological and psychiatric disorders.

165 mising therapeutic target for stress-related psychiatric disorders.

166 about the role of the blood-brain barrier in psychiatric disorders.

167 ubspecialty of clinical radiology mainly for psychiatric disorders.

168 mplications for disrupted decision-making in psychiatric disorders.

169 levant to inflexible repetitive behaviors in psychiatric disorders.

170 mory is impaired in several neurological and psychiatric disorders.

171 volvement in multiple neurodevelopmental and psychiatric disorders.

172 he modulation of behaviors with relevance to psychiatric disorders.

173 abnormal connectivity of which is central to psychiatric disorders.

174 zation of the brain is implicated in several psychiatric disorders.

175 rging as an important treatment modality for psychiatric disorders.

176 and hallucinations are hallmark symptoms of psychiatric disorders.

177 modulation as a treatment for stress-related psychiatric disorders.

178 complications associated with stress-related psychiatric disorders.

179 ts against the development of stress-related psychiatric disorders.

180 in a battery of behavioral tasks relevant to psychiatric disorders.

181 as an off-label treatment for mood and other psychiatric disorders.

182 s currently under investigation for treating psychiatric disorders.

183 2) was associated with increased risk of any psychiatric disorders.

184 Cognitive deficits are a common feature of psychiatric disorders.

185 ern society, is a major risk factor for many psychiatric disorders.

186 salutary social bonds and clinically defined psychiatric disorders.

187 tput of NAc MSNs contributes to a variety of psychiatric disorders.

188 ly linked to the genetic mechanisms of major psychiatric disorders.

189 of particular relevance for neuroscience and psychiatric disorders.

190 ction to altered risk for the development of psychiatric disorders.

191 l pregestational diabetes, hypertension, and psychiatric disorders.

192 ur developmental patterns leading to diverse psychiatric disorders.

193 rculation of individuals with stress-related psychiatric disorders.

194 nteracting with MICALL2 were associated with psychiatric disorders.

195 e for examining interoceptive dysfunction in psychiatric disorders.

196 the context of intellectual disabilities and psychiatric disorders.Brain cytoplasmic (BC1) RNA is a n

197 ts share genetic loci with developmental and psychiatric disorders.Individual SNPs have small effects

198 o develop new mechanisms-based therapies for psychiatric disorders.SIGNIFICANCE STATEMENT Social beha

199 ulated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes.

200 such as women who experience PPD as a first psychiatric episode.

201 fy the rates of suicide after discharge from psychiatric facilities and examine what moderates those

202 The suicide rate after discharge from psychiatric facilities was the main outcome, and the ass

203 d questionnaires concerning psychosocial and psychiatric functioning.

204 Our findings suggest that psychiatric genetic risk factors expressed in astrocytes

205 In psychiatric genetics specifically, targeting intermediat

206 ate the many sources of heterogeneity within psychiatric genetics that can obscure the identification

207 ch approaches (e.g., nonhuman animal models, psychiatric genetics, pharmacologic challenge) to elucid

208 1235 trios) were either obtained through the Psychiatric Genomics Consortium (PGC) or the Danish iPSY

209 land group of the most recent release of the Psychiatric Genomics Consortium (PGC), the PGC2-MDD (Maj

210 ng consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroima

211 results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of t

212 te PRSs, we used the results from the latest Psychiatric Genomics Consortium schizophrenia meta-analy

213 dy of the Schizophrenia Working Group of the Psychiatric Genomics Consortium with data on macroscale

214 from the Tobacco And Genetics Consortium and Psychiatric Genomics Consortium.

215 phenotypic measures from 14 data sets of the Psychiatric Genomics Consortium.

216 e association study results generated by the Psychiatric Genomics Consortium.

217 genomic studies of other medical conditions, psychiatric genomics researchers should offer findings t

218 ated in both neurobiological functioning and psychiatric health.

219 age, weight, injection drug use history, and psychiatric history or recent psychoactive medication.

220 .6% of childbirths among women with no prior psychiatric history.

221 or adult-onset ADHD independent of a complex psychiatric history.

222 ntrol study was conducted at a tertiary care psychiatric hospital from May 1, 2010, to November 30, 2

223 Services are predominantly based in psychiatric hospitals.

224 variants conferring moderate to high risk of psychiatric illness are associated with having fewer chi

225 impairment, but also metabolic syndrome and psychiatric illness including depression (1,2).

226 is or represent a transdiagnostic feature of psychiatric illness remains unclear.

227 MENT Schizophrenia is a profoundly disabling psychiatric illness with a devastating impact not only u

228 ne system in vulnerability to stress-related psychiatric illness.

229 connectivity as a transdiagnostic feature of psychiatric illness.

230 ptic function and cognition, are abnormal in psychiatric illnesses such as schizophrenia.

231 PNN integrity are implicated in a variety of psychiatric illnesses, suggesting a potential global rol

232 major depressive disorder (rMDD) are common psychiatric illnesses.

233 ot disrupt treatment regimens for underlying psychiatric illnesses.

234 gnition, and influence many neurological and psychiatric illnesses.

235 rimary outcome was compulsory admission to a psychiatric inpatient bed, compared with people admitted

236 py may be associated with reduced short-term psychiatric inpatient readmissions among psychiatric inp

237 iable was relapse, defined as admission to a psychiatric inpatient unit after exacerbation of symptom

238 with a reduced 30-day readmission risk among psychiatric inpatients with severe affective disorders f

239 erm psychiatric inpatient readmissions among psychiatric inpatients with severe affective disorders.

240 From a population-based sample of 490252 psychiatric inpatients, a sample was drawn that consiste

241 Psychiatric interventions offered after natural disaster

242 cal basis through which THC exposure elicits psychiatric manifestations.

243 , and behavioral effects of cannabis related psychiatric manifestations.

244 cohol-dependent individuals with no comorbid psychiatric, medical, or drug abuse disorders were scann

245 cannabis for opioids, and also possibly for psychiatric medications.

246 Its potential as a psychiatric medicine has recently been demonstrated and

247 OUND DATA: Concerns regarding severe adverse psychiatric outcomes after GBP have been raised.

248 associations between air pollution and acute psychiatric outcomes, the association with depression on

249 driver of sex differences that are found in psychiatric outcomes.

250 irth regarding their potential connection to psychiatric outcomes.

251 on Medical Status Ratings Twenty-one elderly psychiatric patients had lower levels of psychopathology

252 gs from these studies highlight that not all psychiatric patients have microglial activation.

253 articipants including healthy volunteers and psychiatric patients with schizophrenia, depression, or

254 ly gained attention as a mediator of complex psychiatric phenomena such as stress and addiction.

255 d blood-based DNAm for insights into ASD and psychiatric phenotypes more broadly.

256 In addition, psychiatric populations should have access to the potent

257 rate hypotheses about social dysfunctions in psychiatric populations.

258 longitudinal relationship between childhood psychiatric problems and brain development.

259 S or ICS/LABA were assessed for physical and psychiatric problems and followed up for one year from a

260 cipants underwent a diagnostic interview and psychiatric ratings, a comprehensive neuropsychological

261 talization and treatment failure (defined as psychiatric rehospitalization, suicide attempt, disconti

262 The Integrative Psychiatric Research (iPSYCH) consortium has established

263 The value of cognitive assessments in psychiatric research can be substantially increased by a

264 Psychiatric research has mostly accepted these denotatio

265 Psychiatric research may benefit from approaching psycho

266 ers, the Danish Twin Register and the Danish Psychiatric Research Register, we identified a sample of

267 he brain-based neuropathological paradigm of psychiatric research then dominant in most European cent

268 e that the transcriptional regulation by the psychiatric risk gene TCF4 enhances NMDA receptor-depend

269 re, we show in utero gain-of-function of the psychiatric risk gene transcription factor 4 (TCF4) seve

270 ht into the transcriptional landscape of the psychiatric risk gene, NRG3, in human neocortical develo

271 eir use is associated with some physical and psychiatric risks.

272 g a bifactor model of item-level data from a psychiatric screening interview, which delineated four f

273 arge for inpatients or clinical contact with psychiatric services for outpatients (patient episode) t

274 toms within 2 years of first presentation to psychiatric services.

275 patients recently discharged from inpatient psychiatric services.

276 t study using national registers of clinical psychiatric services.

277 of broader violence reduction strategies in psychiatric settings.

278 ul but modest contribution and may depend on psychiatric space.

279 physical and quality of life status, but not psychiatric status, were associated with fewer hospitali

280 physical and quality of life status, but not psychiatric status, were associated with fewer subsequen

281 was also shorter in relatives (regardless of psychiatric status; p<0.01) and patients with BD not on

282 -harm or depression, which may be in need of psychiatric support after GBP.

283 e used to determine the associations between psychiatric symptom ratings and quantitative anatomic an

284 with life, neurobehavioral symptom severity, psychiatric symptom severity, and sleep impairment were

285 c steroid (AAS) use has been associated with psychiatric symptoms and cognitive deficits, yet we have

286 differences in emotional responses and many psychiatric symptoms between males and females.

287 tempts before treatment may reflect emerging psychiatric symptoms that trigger medical consultations

288 However, as for many other psychiatric symptoms the biological mechanisms underlyin

289 ulation study with data on social habits and psychiatric symptoms to compare prevalences of depressio

290 tanding fluctuations in emotional memory and psychiatric symptoms.

291 Delirium is a common and serious psychiatric syndrome caused by an underlying medical con

292 mes pathological in trauma- and stress-based psychiatric syndromes, such as PTSD.

293 ms of genetic variation that might influence psychiatric traits and then finally, the heterogeneity t

294 Many psychiatric traits are sexually dimorphic in terms of pr

295 e assessed using measures of behavioural and psychiatric traits with logistic regression being used t

296 tween loneliness and several personality and psychiatric traits.

297 oups with sexually-dimorphic behavioural and psychiatric traits.

298 patients recently discharged from inpatient psychiatric treatment at ages 15 to 44 years.

299 of NRG3 signaling as a potential target for psychiatric treatment development.

300 residents were discharged from an inpatient psychiatric unit or ward on or after their 15th birthday