ライフサイエンスコーパス: psychoactive

1 tivation of the human PXR by hyperforin, the psychoactive agent in St. John's wort.

2 These transporters interact with multiple psychoactive agents including cocaine, amphetamines and

3 norepinephrine (NET) are targets of multiple psychoactive agents, and their dysfunction has been impl

4 lease and are important targets for multiple psychoactive agents, including amphetamines, cocaine, an

5 targets for a number of clinically relevant psychoactive agents, including antidepressants, cocaine,

6 partly because it is the target of multiple psychoactive agents, including the antidepressant paroxe

7 aptic ionotropic receptors in the effects of psychoactive and addictive drugs.

8 d other cannabinoids are responsible for the psychoactive and medicinal properties of Cannabis sativa

9 d type 1 (CB1) receptor mediates marijuana's psychoactive and reinforcing properties.

10 Acute NPS toxicity includes significant psychoactive and sympathomimetic effects.

11 The abuse of psychoactive 'bath salts' containing cathinones such as

12 ed changes in Gi and Gq activity predict the psychoactive behavioral effects of a variety of pharmoco

13 In contrast to other psychoactive cathinones (eg, mephedrone), MDPV is not a

14 ht mass spectrometer (APIM(tof)MS) to detect psychoactive cathinones and tryptamines from aqueous pha

15 et of Delta(9)-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide r

16 Delta(9)-tetrahydrocannabinol (THC), a major psychoactive component found in marijuana or anandamide,

17 tetrahydrocannabinol (Delta9-THC), the major psychoactive component in marijuana, can lead to enhance

18 iangle up(9)-tetrahydrocannabinol (THC), the psychoactive component in marijuana.

19 at in mice, subchronic administration of the psychoactive component of cannabis, delta9-tetrahydrocan

20 trahydrocannabinol (Delta(9)-THC), the major psychoactive component of cannabis, produced dose-depend

21 elta(9)-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, results in behaviora

22 -9-tetrahydrocannabinol (THC) is the primary psychoactive component of cannabis.

23 Nicotine, the major psychoactive component of cigarette smoke, modulates neu

24 elta(9)-tetrahydrocannabinol (THC), the main psychoactive component of marijuana (Cannabis sativa), i

25 Delta(9)-tetrahydrocannabinol (THC), a major psychoactive component of marijuana, and AEA.

26 Delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct ca

27 m, most popularly known as the target of the psychoactive component of marijuana, Delta(9)-tetrahydro

28 s capable of oxidatively degrading the major psychoactive component of marijuana, Delta9-tetrahydroca

29 etrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregu

30 Delta9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, is toxic for hippoc

31 elta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, suppresses host imm

32 Cannabidiol (CBD) is a non-psychoactive component of marijuana, which has anti-infl

33 by Delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana.

34 thylenedioxymethamphetamine (MDMA), the main psychoactive component of the recreational drug ecstasy,

35 Nicotine, the main psychoactive component of tobacco, and (-)-Delta(9)-tetr

36 changes primarily involve an increase of the psychoactive compound (9)-tetrahydrocannabinol (THC) and

37 The main psychoactive compound in marijuana, Delta(9)-tetrahydroc

38 trahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regu

39 cs oxantel pamoate and pyrantel pamoate; the psychoactive compounds hydroxyzine pamoate (Vistaril) an

40 The protocol is also a tool for testing psychoactive compounds in the context of a vertebrate br

41 ts possible role in the in vivo synthesis of psychoactive compounds or neurotoxins and has been chara

42 of fast-acting antidepressants and possibly psychoactive compounds with effectiveness against other

43 The psychoactive constituent in cannabis, Delta(9)-tetrahydr

44 of delta-9-tetrahydrocannabinol, the primary psychoactive constituent in cannabis.

45 Given that the psychoactive constituent of cannabis binds to the CB1 ca

46 The discovery of the main psychoactive constituent of Cannabis sativa L., Delta(9)

47 The psychoactive constituent of cannabis, Delta(9)-tetrahydr

48 Rats were exposed to THC, the main psychoactive constituent of cannabis, for 3 days (two in

49 -Delta9-tetrahydrocannabinol (THC; the major psychoactive constituent of marijuana), due to enhanced

50 The main psychoactive constituent of marijuana, (-)-Delta(9)-tetr

51 eptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agoni

52 elta(9)-tetrahydrocannabinol, the main plant psychoactive constituent, activate both cannabinoid rece

53 pairs memory through interaction between its psychoactive constituent, Delta-9-tetrahydrocannabinol (

54 The rewarding properties of the psychoactive constituents of marijuana, termed "cannabin

55 g 1, 1992, and June 30, 1995, and had used a psychoactive drug (tricyclic antidepressant, benzodiazep

56 The psychoactive drug +/-3,4-methylenedioxymethamphetamine (

57 ctive serotonin-reuptake inhibitor, or other psychoactive drug [mainly major tranquillisers]) between

58 Caffeine, the most commonly ingested psychoactive drug and a nonselective adenosine receptor

59 The psychoactive drug caffeine influences neuronal physiolog

60 es), distinguish the pyrrolidones from other psychoactive drug classes.

61 te (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of atten

62 ormone response to stimuli associated with a psychoactive drug in rats and suggest that the effect is

63 Caffeine is the most widely-consumed psychoactive drug in the world, but our understanding of

64 Nicotine, the main psychoactive drug in tobacco, is one of the most heavily

65 lowered by amphetamine, indicating that the psychoactive drug induced a conditioned reduction in tas

66 domide ([+]-alpha-phthalimidoglutarimide), a psychoactive drug that readily crosses the blood-brain b

67 Thalidomide, a psychoactive drug that readily crosses the blood-brain b

68 about current and past church attendance and psychoactive drug use.

69 s outweighed by that of a highly reinforcing psychoactive drug.

70 odiazepines (1.62 [1.24-2.12]), and 47 other psychoactive drugs (0.88 [0.62-1.25]).

71 or dependence was the highest for prescribed psychoactive drugs (hazards ratio, 13.0; 95% confidence

72 d in laboratory animals for almost all other psychoactive drugs abused by humans, as well as for nico

73 Among the psychoactive drugs analyzed, the median environmental em

74 Pure psychoactive drugs and direct routes of administration a

75 examined the association between the use of psychoactive drugs and road-traffic accidents.

76 duced neuroadaptations and demonstrates that psychoactive drugs and stress trigger divergent changes

77 Self-medication for pain with psychoactive drugs appears especially problematic among

78 ters that are the molecular targets for such psychoactive drugs as cocaine, amphetamines, and therape

79 rce of durable fibers, nutritious seeds, and psychoactive drugs but few economic plants are so poorly

80 Currently available psychoactive drugs exert their effects through 3 or 4 of

81 neral therapeutic classes into which various psychoactive drugs fall, based on high-content statistic

82 cher (F344) inbred rat strains to stress and psychoactive drugs have been related to differences in t

83 se and abuse of most other licit and illicit psychoactive drugs have been shown to be substantially h

84 tor studies suggest that commonly prescribed psychoactive drugs impair driving skills.

85 can contribute to the regulation of mood by psychoactive drugs in mental illnesses such as bipolar d

86 The median concentrations of psychoactive drugs in sludge from domestic WWTPs were 1.

87 ention time can affect the concentrations of psychoactive drugs in sludge.

88 tem and is a site of action for a variety of psychoactive drugs including antidepressants, amphetamin

89 convincingly provided in vivo evidence that psychoactive drugs increase dopamine (DA) levels in huma

90 A major obstacle for the discovery of psychoactive drugs is the inability to predict how small

91 on of the cellular and behavioral effects of psychoactive drugs of abuse, we developed Cre/loxP condi

92 Little is known about the acute effects of psychoactive drugs on impulsivity and decision making in

93 be involved in the regulation of behavior by psychoactive drugs such as antipsychotics and mood stabi

94 is rats show greater behavioral responses to psychoactive drugs than Fischer rats and they fail to sh

95 nicotine, cocaine, or amphetamine, which are psychoactive drugs that induce well-documented neuroadap

96 emission rates of some of the metabolites of psychoactive drugs through WWTP discharges were higher t

97 A high increase in the use of psychoactive drugs was detected between 2010 and 2014, e

98 Psychoactive drugs with minimal abuse potential do not c

99 metabolic variations, medical comorbidities, psychoactive drugs, alcohol use, mental state) tend to v

100 he determination of common legal and illegal psychoactive drugs, and major metabolites, in breast mil

101 iffer in the initial, reinforcing effects of psychoactive drugs, but not in responses seen after the

102 titute the principal sites of action of many psychoactive drugs, including amphetamines and cocaine,

103 Several psychoactive drugs, including antidepressants, can modul

104 ilieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and

105 evious findings with other licit and illicit psychoactive drugs, individual differences in caffeine u

106 KC is a target for the therapeutic action of psychoactive drugs, our findings indicate that the patho

107 fluences of emotionality, thought speed, and psychoactive drugs--and atypical differences in individu

108 control signaling pathways targeted by many psychoactive drugs.

109 isease, neurosurgical procedures, and use of psychoactive drugs.

110 y microarray studies in animals administered psychoactive drugs.

111 gesting behavioral synergism between the two psychoactive drugs.

112 tanding platelet function and the effects of psychoactive drugs.

113 ed as a basis for decisions about the use of psychoactive drugs.

114 ronmental factors modulate responsiveness to psychoactive drugs.

115 r in behavioral and biochemical responses to psychoactive drugs: Lewis rats show greater behavioral r

116 the circulating drug, thus terminating both psychoactive effects and drug toxicity.

117 While its psychoactive effects are mainly associated with GABAergi

118 Hallucinogens mediate many of their psychoactive effects by activating serotonin 2A receptor

119 not A-NK-amide, showed acute and persisting psychoactive effects in mice.

120 ly consumed behavioral drug caffeine, as the psychoactive effects of caffeine are mediated largely by

121 THC is thought to produce the main psychoactive effects of cannabis, while CBD does not app

122 (decreased) animals, which suggests that the psychoactive effects of cocaine are influenced by the st

123 The physiological and psychoactive effects of cocaine are similar regardless o

124 -steroid hormone estradiol (E2) enhances the psychoactive effects of cocaine, as evidenced by clinica

125 of the phage-displayed proteins to block the psychoactive effects of cocaine.

126 1) cannabinoid receptor mediates many of the psychoactive effects of Delta(9)THC, the principal activ

127 Direct psychoactive effects of exogenously administered androge

128 approach, called DISSECTIV, to mitigate the psychoactive effects of fenethylline and show that its r

129 an effective immunotherapy for reducing the psychoactive effects of fentanyl class drugs.

130 tly neurogenesis by overcoming the undesired psychoactive effects of neuronal CB(1) cannabinoid recep

131 g site for cocaine and other stimulants, the psychoactive effects of which are associated primarily w

132 ol (CBD), a constituent of cannabis with few psychoactive effects, has been reported in some studies

133 nol, have been studied extensively for their psychoactive effects, it has become apparent that certai

134 DA receptors (NMDARs) may trigger ketamine's psychoactive effects, ketamine or its major metabolite n

135 ral) cannabinoid receptors should be free of psychoactive effects, perhaps allowing for more effectiv

136 uppressive properties while demonstrating no psychoactive effects.

137 treatment of acute and chronic pain without psychoactive effects.

138 iscussed, with particular reference to their psychoactive effects.

139 cetylcholine receptors (nAChRs) to exert its psychoactive effects.

140 crush the pills and smoke the powder for its psychoactive effects.

141 crease the enzyme's ability to hydrolyze the psychoactive enantiomer of cocaine.

142 e include the conversion of cocaine to a non-psychoactive form, the degradation of nicotine, activati

143 hesized in 1938 and identified as (potently) psychoactive in 1943.

144 Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the shrub, Taberna

145 Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the West African s

146 elta(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing conc

147 a(9)-tetrahydrocannabinol (THC), the primary psychoactive ingredient in cannabis, are believed to be

148 The primary psychoactive ingredient in cannabis, Delta9-tetrahydroca

149 elta(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, play major roles in

150 9)-tetrahydrocannabinol (THC), the principal psychoactive ingredient in marijuana, acts as a partial

151 The principal psychoactive ingredient in marijuana, Delta(9)-tetrahydr

152 with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsucces

153 of Delta9-tetrahydrocannabinol, the primary psychoactive ingredient in marijuana, whereas S1P recept

154 elta(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana.

155 ydrocannabinol (Delta9-THC) is the principal psychoactive ingredient in marijuana.

156 Tetrahydrocannabinol (Delta9-THC), the major psychoactive ingredient in preparations of Cannabis sati

157 Nicotine, the psychoactive ingredient in tobacco, can be neuroprotecti

158 used by humans, as well as for nicotine, the psychoactive ingredient in tobacco, these studies would

159 ivated by Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiol

160 tetrahydrocannabinol (delta-9-THC), the main psychoactive ingredient of cannabis, on anxiety and on a

161 elta-9-tetrahydrocannabinol (THC), a primary psychoactive ingredient of marijuana, affects locomotor

162 Single injections with the main psychoactive ingredient of marijuana, Delta(9)-tetrahydr

163 Nicotine, the main psychoactive ingredient of tobacco smoke, induces negati

164 Nicotine, the main psychoactive ingredient of tobacco, induces negative emo

165 tetrahydrocannabinol (THC), marijuana's main psychoactive ingredient.

166 ein-coupled receptor (GPCR) triggered by the psychoactive ingredients in marijuana, as well as endoge

167 The only other psychoactive medication allowed was lorazepam for agitat

168 racteristics such as severity, duration, and psychoactive medication do further impact on biological

169 es (r = 0.91, P<.001), quantity of different psychoactive medication dosages 8 hours prior to assessm

170 Risk of new psychoactive medication prescriptions was also increased

171 tical illness, new psychiatric diagnoses and psychoactive medication use is increased in the months a

172 nder, dementia stage, function, comorbidity, psychoactive medication use) and nesting effects of resi

173 d documented psychiatric history or received psychoactive medication within 30 days before entering t

174 e history, and psychiatric history or recent psychoactive medication.

175 psychiatric illnesses and prescriptions for psychoactive medications in the 5 years before critical

176 enduring effects have been observed for the psychoactive medications, which appear to be largely pal

177 nted for age, sex, adiposity, and the use of psychoactive medications.

178 at creates antibodies against heroin and its psychoactive metabolites by presenting multihaptenic str

179 The street drug "bath salts" are psychoactive mixtures of cathinone derivatives.

180 tic target, as it is metabolized to multiple psychoactive molecules.

181 re we report that serotonin differs from the psychoactive N-methyltryptamines by its ability to engag

182 Salvinorin A is a psychoactive natural product that has been found to be a

183 CBD, which alone produced no significant psychoactive or cardiovascular effects, did not signific

184 A total of 16 psychoactive pharmaceuticals (0.12-460 ng/g dry weight)

185 This study draws upon a nationwide survey of psychoactive pharmaceuticals (i.e., antischizophrenics,

186 vity contingent upon the administration of a psychoactive pharmacological agent has been demonstrated

187 of puparial casings; (4) distinguish between psychoactive plants products; and (5) differentiate betw

188 Five-year preadmission psychoactive prescription rates were similar to hospital

189 e and show that its rapid-onset and distinct psychoactive properties are facilitated by functional sy

190 d in traditional spiritual practices for its psychoactive properties by the Mazatecs of Oaxaca, Mexic

191 Although the psychoactive properties of fenethylline have been report

192 AR agonists such as lisuride lack comparable psychoactive properties.

193 -like hallucinations, while others lack this psychoactive property entirely.

194 ity for CB1 and CB2 receptors nor with their psychoactive side effects.

195 Moreover, THC produces motor and psychoactive side effects.

196 cts but are also associated with undesirable psychoactive side effects.

197 e because of the dose limitations imposed by psychoactive side effects.

198 receptor agonists remain limited because of psychoactive side effects.

199 The psychoactive stimulant 3, 4-methylenedioxymethamphetamin

200 n by the trade name Captagon, is a synthetic psychoactive stimulant that has recently been linked to

201 Psychoactive stimulants that activate the dopamine D(1)

202 ot applicable to detect an alarming array of psychoactive stimulants, tranquilizers, and synthetic op

203 ettes to facilitate covert use of a range of psychoactive stimulants.

204 rain by chronic exposure to several types of psychoactive stimuli, including drugs of abuse, stress,

205 psychiatric diagnostic categories assessed, psychoactive substance abuse conferred the highest risk

206 dioxy-N-methylcathinone (methylone) is a new psychoactive substance and the beta-keto analog of 3,4-m

207 f genetic and environmental risk factors for psychoactive substance dependence was similar in males a

208 Caffeine is the most widely consumed psychoactive substance in the world and presents with wi

209 Nicotine is the primary psychoactive substance in tobacco, and it exerts its eff

210 tic factors are important in the etiology of psychoactive substance use (PSU), we know little of how

211 %; alcohol dependence, 11.2%; and nonalcohol psychoactive substance use dependence, 15.2%.

212 t 12-month alcohol dependence and nonalcohol psychoactive substance use dependence.

213 on deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abu

214 s were more likely to receive a diagnosis of psychoactive substance use disorder but no other psychia

215 he criteria for an anxiety disorder, 60% for psychoactive substance use disorder, 53% for another par

216 he risks in first-degree relatives for ADHD, psychoactive substance use disorder, alcohol dependence,

217 t patients with concurrent schizophrenia and psychoactive substance use disorders may be adequately t

218 on demographic characteristics and comorbid psychoactive substance use in 2,200 consecutive involunt

219 the distribution of diagnoses, and comorbid psychoactive substance use in a large sample of patients

220 ly, the diagnostic distribution and comorbid psychoactive substance use in all 2,200 admissions were

221 Unexpectedly, the impact of comorbid psychoactive substance use was relatively modest and sho

222 aches to prevention and treatment of illicit psychoactive substance use, abuse, and dependence, we ne

223 The electrochemical sensing of new psychoactive substance(s) (NPSs), synthetic cathinone de

224 Caffeine is the most commonly used psychoactive substance, and consumption by adolescents h

225 Caffeine is a widely consumed psychoactive substance, but little is known about the ef

226 Caffeine, the most widely consumed psychoactive substance, produces complex pharmacological

227 the influence of cannabis, specifically the psychoactive substance, tetrahydrocannabinol (THC).

228 Caffeine is an addictive psychoactive substance.

229 affeine is by far the most commonly consumed psychoactive substance.

230 SCs) continue to be the largest group of new psychoactive substances (NPS) monitored by the European

231 c cathinones are among the most consumed new psychoactive substances (NPS), but their increasing numb

232 As novel psychoactive substances appeared in Europe, they should

233 enetic risk factors for dependence on common psychoactive substances cannot be explained by a single

234 New psychoactive substances constitute a growing and dynamic

235 The abuse of synthetic psychoactive substances known as "designer drugs," or "n

236 neral physiological and cognitive effects of psychoactive substances or psychopathological conditions

237 individuals will use or misuse one class of psychoactive substances rather than another.

238 New psychoactive substances refer to emerging substances tha

239 ubstances known as "designer drugs," or "new psychoactive substances" (NPS), is increasing at an alar

240 amine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitor

241 Other psychoactive substances, such as increasingly prescribed

242 The electrochemical sensing of new psychoactive substances, synthetic cannabinoids (SCs), c

243 bute to dependence on both licit and illicit psychoactive substances, we know little of how these ris

244 mind-altering compounds, also known as "new psychoactive substances," is increasing globally at an a

245 and families and exposure to other prenatal psychoactive substances.

246 available and one of the most commonly used psychoactive substances.

247 vely, had current diagnoses of dependence on psychoactive substances.

248 Europe by the EU Early Warning System on new psychoactive substances.

249 s (SCs) are among the most commonly used new psychoactive substances.

250 btained from a single instrument run for the psychoactive substances.

251 In patients without psychoactive treatment (n = 101), the incidence of falls

252 Patients taking psychoactive treatment (n = 21) had a higher frequency o

253 These findings show that, like several other psychoactive treatments, repeated rTMS sessions can exer

254 cribe how toluene, the most commonly studied psychoactive volatile solvent, alters synaptic transmiss