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1 esidue of beta-galactosyl 1-->1 sphingosine (psychosine).
2 orm for developing a medicinal chemistry for psychosine.
3 actolipids, including galactosylceramide and psychosine.
5 he toxic metabolite of galactosylceramidase, psychosine, a potent inhibitor of protein kinase C (PKC)
6 ming cells resulting from an accumulation of psychosine, a toxic substrate of galactosylceramidase an
7 the cytotoxic lipid, galactosylsphingosine (psychosine), accumulates in the CNS and peripheral nervo
9 hallmarks such as gliosis, globoid cells and psychosine accumulation are present throughout the nervo
10 gue against a causative relationship between psychosine accumulation, white matter loss and gliosis.
11 sults are consistent with an accumulation of psychosine, an inhibitor of PKC, and suggest that the si
12 ebrosidase loss leads to the accumulation of psychosine and subsequent oligodendrocyte cell death, de
13 as lyso-phosphatidylcholine, galactosyl-Sph (psychosine), and lactosyl-Sph at 0.5-10 microM did not s
14 nce sphingolipid classes (e.g., sphingosine, psychosine, and lysosphingomyelin) and molecular species
17 phenomenon may provide a mechanism by which psychosine can exert its known inhibitory effect on prot
19 yde conjugate of beta-galactosylsphingosine (psychosine) found in brain white matter, enhances p140tr
20 We hypothesized that the accumulation of psychosine (galactosyl-sphingosine) in the TWI CNS may r
21 d by the accumulation of a toxic metabolite, psychosine (galactosylsphingosine), which is a substrate
23 e knockout mice and the significantly higher psychosine in the brain of the galc(-/-), bgal(+/-) mice
24 This study underscores the possible role of psychosine in the effect of inducible nitric oxide synth
25 , we have tested neuroprotective efficacy of psychosine in vivo, in a rat model of glutamate excitoto
27 xpression results, TDAG8 was dispensable for psychosine-induced formation of multinucleated cells.
28 Myelin-free in vitro analyses showed that psychosine inhibited fast axonal transport through the a
29 presence of lyso-GM3 or its analogue but not psychosine, lactosyl-sphingosine, or lyso-phosphatidylch
30 This study hypothesizes that accumulated psychosine leads to production of cytokines and iNOS exp
32 ological levels of GALC activity and reduced psychosine levels in both the brain and spinal cord, it
39 and implicated by overexpression studies in psychosine-mediated inhibition of cytokinesis and in GC-
40 itical role for TDAG8 in immune development, psychosine-mediated inhibition of cytokinesis, and GC-in
41 cultured cells expressing this receptor with psychosine or structurally related glycosphingolipids re
43 but not sphingosine 1-phosphate (S1P), PAF, psychosine (Psy), glucosyl-beta1'1-sphingosine (Glu-Sph)
45 In this communication, we demonstrate that psychosine specifically accumulates in LRs in the TWI br
47 cant, 16.5%, reduction in the GALC substrate psychosine, the abnormal accumulation of which is believ
48 og muscles had significant capacity to store psychosine, the neurotoxin that accumulates in Krabbe di
49 Schwann cells are particularly sensitive to psychosine, thus leading to a demyelinating phenotype.
50 responded in vitro to medium conditioned by psychosine-treated oligodendrocytes, indicating the like
51 abnormal accumulation of the GALC substrate psychosine, which is thought to play a pivotal role in d
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