ライフサイエンスコーパス: pubertal

1 ntials were recorded from hippocampus of pre-pubertal (~28-32 PND) and pubertal (~35-44 PND) female w

2 hippocampus of pre-pubertal (~28-32 PND) and pubertal (~35-44 PND) female wild-type or alpha4-/- mice

3 sed on these data, it can be speculated that pubertal AAS users with low central 5-HT may be especial

4 Kidney disease in males, pubertal abnormalities in females, ovarian primordial fo

5 Pubertal abnormalities, testis disease, obesity, and ova

6 g kisspeptin, a key neuropeptide involved in pubertal activation and fertility.

7 Aergic transmission plays a critical role in pubertal activation of pulsatile GnRH secretion.

8 Sex differences in pubertal addition of cells coincide with adult sexual di

9 Sex differences in pubertal addition of cells coincide with adult sexual di

10 ncy, and physical sexual dysfunction in male pubertal, adolescent, and young adult cancer survivors.

11 Pubertal adolescents were randomly assigned to receive 8

12 ated with supradiaphragmatic radiotherapy at pubertal ages.

13 There is little high-quality evidence on the pubertal alterations of energy expenditure and intake, a

14 In vivo, expression of Csf1 in both pre-pubertal and adult testes was localized to clusters of L

15 there was a significant interaction between pubertal and adult testosterone, such that testosterone

16 ing has been implicated in the regulation of pubertal and adulthood gonadotropin-releasing hormone (G

17 ich coincided with a severely underdeveloped pubertal and mature ductal tree with profoundly decrease

18 littermate controls at 6 (prepubertal), 10 (pubertal), and 14 (young adult) weeks of age in both sex

19 d after AP-1 blockade in adult, prepubertal, pubertal, and hormone-stimulated mammary glands.

20 satile GnRH release and from juvenile, early pubertal, and midpubertal ovary-intact females.

21 ministration of senktide to female rats with pubertal arrest due to chronic undernutrition rescued VO

22 zed that rapidly deteriorating health of pre-pubertal boys with DMD could be due to diminished anabol

23 ot experience endogenous testosterone during pubertal brain development, and then received either tes

24 EGFR promotes pubertal breast ductal morphogenesis in mice, and both E

25 itional oxidative challenge in preweaning or pubertal but not in young adult Gclm KO mice reduces the

26 and that this increase can be blocked by pre-pubertal, but not post-pubertal, gonadectomy.

27 headaches, including comorbid disorders and pubertal changes, which might lead to the development of

28 o systemic hormonal regulation that triggers pubertal changes.

29 Pre-pubertal children show a relative resistance to death fr

30 ood adiposity with vascular phenotype in pre-pubertal children.

31 However, the pubertal decrease in seizure-like discharges was not see

32 nital anomaly disorder and a common cause of pubertal defects, olfactory dysfunction, growth delays,

33 h downstream effects including malnutrition, pubertal delay, low muscle mass and physical inactivity.

34 physiology, particularly retarded growth and pubertal delay, may exist.

35 versus 1.7% in those >/=14 years; P<0.001), pubertal development (9.5% of children with incomplete v

36 Intake increased with pubertal development (P < 0.001), but the timing and mag

37 r to adult height and reported more advanced pubertal development (P < 0.04).

38 Neural responses to rewards, pubertal development (self-report and testosterone level

39 plicable in children and adolescents late in pubertal development (Tanner stage 5).

40 ice lacking LepR in Kiss1 neurons had normal pubertal development and fertility.

41 inin B (NKB) neurocircuits are essential for pubertal development and fertility.

42 hypogonadism, characterized by an absence of pubertal development and low circulating levels of LH an

43 pin-releasing hormone (GnRH) is critical for pubertal development and maintenance of reproductive com

44 vo implicates the GnRH promoter in mediating pubertal development and periodic reproductive cycling,

45 types associated with the loss of JARID1B in pubertal development and pregnancy.

46 distinctive stages throughout embryonic and pubertal development and reproductive life.

47 2) to test whether individual differences in pubertal development and risk-taking behavior were contr

48 onto cingulate pyramidal neurons during peri-pubertal development and that this increase can be block

49 Although lumen formation during pubertal development appears to involve apoptosis, the m

50 These sex-specific associations with pubertal development are consistent with endocrine-disru

51 Any pubertal development at age 9 years was reported by pare

52 ventromedial PFC increased with both age and pubertal development during self-evaluations in the soci

53 ction control changes as a function of human pubertal development in 14-year-old adolescents (n = 47)

54 ollution in utero and during early life with pubertal development in Hong Kong, China, an area with a

55 d long-term effects on adolescent growth and pubertal development in rural Gambian children.

56 al a novel role for mast cells during normal pubertal development in the mammary gland.

57 Our findings suggest that impaired pubertal development in these patients results from a de

58 nds from RonTK-/- mice exhibited accelerated pubertal development including significantly increased d

59 The timing of pubertal development is driven in part by genetic factor

60 in humans, of which sex-specific effects on pubertal development may be an indicator, is less clear.

61 d adult height, Tanner staging, score on the Pubertal Development Scale), neuroendocrine function (di

62 us and age at menarche were assessed via the Pubertal Development Scale.

63 Pubertal development was categorized by physical examina

64 Incomplete pubertal development was the only independent predictor

65 deleted in GnRH neurons experienced delayed pubertal development with normal fertility.

66 weight, height, body weight, Tanner stage of pubertal development, axial length, and spherical equiva

67 vior participation, child self-esteem, child pubertal development, child and adult perception of thei

68 ed during the VWM task, controlling for age, pubertal development, gender, IQ, and intracranial volum

69 ect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, an

70 that are L-R independently regulated during pubertal development, including genes that regulate lumi

71 ional injury risk behavior were self-esteem, pubertal development, parent monitoring, and parent perc

72 ovaries, with subsequent lack of spontaneous pubertal development, primary amenorrhea, uterine hypopl

73 al phases of ductal expansion, which, unlike pubertal development, proceeds independent of hormonal i

74 d that all aspects of male health, including pubertal development, testosterone production, and sexua

75 cts of BPA on the oviduct, the placenta, and pubertal development.

76 ) for age at menarche, a milestone in female pubertal development.

77 microstructure were examined in relation to pubertal development.

78 tities of food to meet the growth demands of pubertal development.

79 ount of stored energy is required for normal pubertal development.

80 body composition, peak growth velocity, and pubertal development.

81 subcortical to prefrontal structures during pubertal development.

82 posure to organochlorine pesticides (OCP) on pubertal development.

83 entrations that may affect mammary gland and pubertal development.We evaluated the relation of dairy

84 n and that its alterations may contribute to pubertal disorders linked to metabolic stress and negati

85 ailure of gland development, failure of post-pubertal ductal elongation, or delayed growth with ducta

86 further research into hormonal influences on pubertal energy balance and subsequent effects on obesit

87 study was to summarize existing evidence on pubertal energy expenditure and intake in healthy nonobe

88 (KS), which is characterized by anosmia and pubertal failure due to hypogonadotropic hypogonadism.

89 es causing short stature, metabolic disease, pubertal failure, and often have associated nervous syst

90 hylation blocked both events and resulted in pubertal failure.

91 the neurokinin B receptor (TACR3) result in pubertal failure.

92 as a result of stress, increases anxiety in pubertal female mice, in contrast to its anxiety-reducin

93 Pre-pubertal female pigs, age 35 d, were fed a high-energy d

94 Yet, acute LH responses to senktide in pubertal females were preserved, if not augmented, under

95 Overweight early pubertal girls have significant blunting of sleep-relate

96 branching morphogenesis in the embryonic and pubertal gland to be identified.

97 rminal end buds and ductal epithelium of the pubertal gland.

98 can be blocked by pre-pubertal, but not post-pubertal, gonadectomy.

99 Data were dichotomized into prepubertal and pubertal groups and compared through the use of standard

100 pathway linking earlier puberty with reduced pubertal growth (P = 4.6 x 10(-5)) and short adult statu

101 c determinant regulating the timing of human pubertal growth and development.

102 Regular follow-up through pubertal growth is recommended.

103 ural Gambia also illustrate that an extended pubertal growth phase allows very considerable height re

104 ificant effect of supplementation during the pubertal growth spurt and a diminishing effect thereafte

105 rgy flux override conventional mechanisms of pubertal growth to promote the storage of excess energy

106 release) override conventional mechanisms of pubertal growth to promote the storage of excess energy

107 bone mass (the amount attained at the end of pubertal growth) and from the amount of bone lost subseq

108 mation were clearly increased as a result of pubertal growth) as compared with adult subjects (P<0.00

109 of increased bone formation, such as during pubertal growth.

110 tion and enhances bone mineralization during pubertal growth.

111 IGF-1) production and/or release relative to pubertal growth.

112 skeletal mineralization and strength during pubertal growth.

113 ne formation, and are markedly higher during pubertal growth; therefore, they may represent a previou

114 thalates were associated with an increase in pubertal gynecomastia and premature thelarche.

115 n with antiestrogens may diminish persistent pubertal gynecomastia, but treatment with an aromatase i

116 Pubertal gynecomastia, on the contrary, is common and us

117 Tissues from pre- and post-pubertal heifers and mature mice were collected and the

118 Pre-pubertal hormone treatment also accelerates maturation o

119 We find that pre-pubertal hormone treatment drives an early increase in i

120 We next used pre-pubertal hormone treatment to model early puberty onset,

121 ity, and (2) underlining a critical role for pubertal hormones and individual differences in risk-tak

122 We hypothesized that pubertal hormones could regulate maturation of the front

123 breeding species to investigate the role of pubertal hormones in adolescent development.

124 experiments have directly tested the role of pubertal hormones in cortical maturation.

125 developmental windows of neural plasticity; pubertal hormones may trigger the opening of an adolesce

126 in our understanding of how neural circuits, pubertal hormones, and environmental factors contribute

127 The pubertal increase in Kiss1 expression was accompanied by

128 4 subunit expression strongly influences the pubertal increase of delta subunits at the plasma membra

129 Grafts showed pubertal induction of spermatogenesis to the level of pa

130 llular activity may underlie Kiss1 action in pubertal initiation and female reproduction.

131 roportion of menarche loci are important for pubertal initiation in both sexes.

132 known about these variants' relationship to pubertal initiation or tempo.

133 sults contribute to our understanding of the pubertal initiation program in both sexes and indicate t

134 ts in the BMI growth rate around the time of pubertal initiation were apparent starting after 1973.

135 However, a subgroup of (pre)pubertal knockout mice (runts) exhibits a pronounced mal

136 Despite being recommended for all pubertal male patients, sperm banking is not universally

137 xytryptamine, 5-HT) depletion on behavior of pubertal male rats.

138 wing 41% and 25% greater absolute intakes in pubertal males and females, respectively.

139 ele et al. (2017) establish a model for post-pubertal mammary branching morphogenesis in which positi

140 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contrib

141 However, they do exhibit severe defects in pubertal mammary gland development.

142 t is not required in the mature ducts of the pubertal mammary gland.

143 In this Series paper, we discuss pubertal markers, epidemiological trends of puberty init

144 oids), by pregnant women was associated with pubertal maturation (height, weight, body mass index for

145 gest that NKB-NK3R signaling plays a role in pubertal maturation and that its alterations may contrib

146 to the disruptive actions of these drugs on pubertal maturation and the development of reproductive

147 right after birth, upon weaning, and during pubertal maturation into adulthood.

148 Adolescents with more advanced pubertal maturation showed greater aPFC activity when co

149 with timing of the daughter's transition to pubertal maturation stage 2 or above for development of

150 olescents aged 5-17 y (n = 99) who varied in pubertal maturation stage.

151 Pubertal maturation, indexed by testosterone levels, shi

152 ents of the same age, but with less advanced pubertal maturation, showed greater pulvinar and amygdal

153 gnificantly (P < 0.0001) linked to timing of pubertal maturation.

154 scontinued antiepileptic drug therapy during pubertal maturation.

155 ertal mice showed greater survival than post-pubertal mice (76.3% vs. 28.6%), despite exhibiting a si

156 Pubertal mice also failed to learn a hippocampal, LTP-de

157 ough H3K27me3, and deletion of Ezh2 in early pubertal mice results in premature cellular senescence,

158 intra-peritoneal injection of endotoxin, pre-pubertal mice showed greater survival than post-pubertal

159 ly became evident at twenty hours, when post-pubertal mice showed prolonged elevation of serum cytoki

160 In pubertal mice, mammary cell proliferation was greatly re

161 d cap cells, present in terminal end buds of pubertal mice.

162 cription factor in the mammary epithelium of pubertal mice.

163 to reduce pulsatile GnRH secretion in female pubertal monkeys; the later supporting a key role of kis

164 Pubertal morphine exposed females had increased mu- and

165 y was conducted to determine whether chronic pubertal morphine exposure alters the expression of mu-

166 ng/ml (2.23, 5.05) in those classed as early pubertal (n = 460, P</=0.001).

167 For females classified as post-pubertal (n = 848) at the time of assessment median (IQR

168 hin double mutant (mdx-dm) mice to mimic pre-pubertal nadir androgen condition resulted in premature

169 djusted by TEQs, was associated with earlier pubertal onset [TV = -8.3 months (95% CI:-16.2, -0.3)] a

170 owest TEQ quartile was associated with later pubertal onset [TV = 11.6 months (95% CI: 3.8, 19.4); G2

171 ds [and their toxic equivalents (TEQs)] with pubertal onset and maturity among Russian boys enrolled

172 pubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although no

173 tion and may have critical repercussions for pubertal onset in adolescent users.

174 to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies.

175 elopmental switches, including the timing of pubertal onset in humans.

176 indicate that although mechanisms regulating pubertal onset in males and females may largely be share

177 at sites extrasynaptic to GABAergic input at pubertal onset in tissue of wild-type (WT) mice.

178 er molecular responses to dioxin exposure or pubertal onset influence the association between peripub

179 recurrent early-onset MDD, age of onset, pre-pubertal onset MDD or typical-like MDD from a latent cla

180 ously, as well as a significant delay in the pubertal onset of estrous cycles compared with control a

181 Pubertal onset was based on testicular volume and on gen

182 Pubertal onset was defined as TV > 3 mL, G2, or P2.

183 their axonal extension to the ME, timing of pubertal onset, and fertility in these mice.

184 r plasmalemmal delta subunit localization at pubertal onset, electron microscopic-immunocytochemistry

185 Pubertal onset, initiated by pulsatile gonadotropin-rele

186 At pubertal onset, plasmalemmal localization of the delta s

187 pubertal serum dioxin concentration and male pubertal onset.

188 peripubertal serum dioxin concentration and pubertal onset.

189 ippocampal pyramidal cells of female mice at pubertal onset.

190 sponse to hormone fluctuations that occur at pubertal onset.

191 changes in GnRH secretion are essential for pubertal onset.

192 ent organic pollutants (POPs) in relation to pubertal onset.

193 , most studies address either developmental, pubertal, or adulthood exposures, with few investigation

194 age BMI Z-scores (0.95+/-1.98) compared with pubertal participants (n = 45; 1.92+/-0.60), but this re

195 In pubertal participants this was not observed (SDS, 0.06;

196 Additionally, the adoptive transfer of pre-pubertal peritoneal cells improved the survival of post-

197 of post-pubertal recipient mice, while post-pubertal peritoneal cells or vehicle did not.

198 on induces delayed mammary growth during the pubertal phase and abnormal cell morphology during lacta

199 he relative insulin resistance brought on by pubertal physiology.

200 ar networks, and hence in the control of the pubertal process as a whole.

201 secretion from the CNS is a hallmark of the pubertal process.

202 and glial subsets involved in initiating the pubertal process.

203 ved after 14 mo of treatment to have delayed pubertal progression with impaired testicular descent an

204 anguineous family that results in failure of pubertal progression, indicating that functional kisspep

205 We evaluated skeletal maturation (bone age), pubertal progression, serum testosterone levels, height

206 duces a schizophrenia-like phenotype in post-pubertal rats.

207 gonadal male monkeys in association with the pubertal reactivation of gonadotropin secretion.

208 ritoneal cells improved the survival of post-pubertal recipient mice, while post-pubertal peritoneal

209 dentify peritoneal cells as mediators of pre-pubertal resistance.

210 s before (juvenile) and after (pubertal) the pubertal resurgence of pulsatile GnRH release and from j

211 ase of development and may contribute to the pubertal resurgence of pulsatile GnRH release, the centr

212 lopmental trajectory is likely linked to the pubertal rise and premenopausal fall of estradiol levels

213 present study investigated the effect of the pubertal rise in gonadal steroid levels on the subsequen

214 Microarray analysis of pubertal RonTK-/- glands revealed 393 genes temporally i

215 mRNA expression was observed in primiparous, pubertal saline-treated females when compared to nullipa

216 expression were observed during lactation in pubertal saline-treated females; however, increased mu-

217 We found that in primary pre-pubertal Sertoli cells and in adult Sertoli line, TLR4\N

218 d seizure-like discharges in over 60% of pre-pubertal slices, but only in 7% of pubertal slices, wher

219 0% of pre-pubertal slices, but only in 7% of pubertal slices, where the coastline length was reduced

220 lls but is reduced substantially during post-pubertal spermatogenesis.

221 uring infancy was negatively associated with pubertal stage and breast development, whereas among 2,1

222 erent growth phases with clinically assessed pubertal stage at approximately age 11 years (as indicat

223 Pubertal stage did not account for sex disparities.

224 Pubertal stage was Tanner 4 for pubic hair and penile si

225 adjusting for birth weight, gestational age, pubertal stage, age, ethnicity, socioeconomic position,

226 EAH in both paradigms after age, sex, race, pubertal stage, and meal intake were controlled for (P v

227 ight, body mass index percentile, %BF, FFST, pubertal stage, dietary intake, physical activity, and s

228 In multivariable analysis, advanced pubertal stage, greater height Z-score, difficulty walki

229 in girls and were positively associated with pubertal stage, measures of central and peripheral adipo

230 ntake were examined with adjustment for age, pubertal stage, physical fitness, socioeconomic status,

231 longitudinal data, adjusted for baseline and pubertal stage, showed that the zinc group had significa

232 in childhood were negatively associated with pubertal stage.

233 dels were adjusted for age, sex, season, and pubertal stage.

234 umed more energy than did females across all pubertal stages (P < 0.001).

235 measure energy intakes of youth at different pubertal stages.

236 until age 17-18 years, a physician performed pubertal staging [genitalia (G), pubarche (P), and testi

237 res were made every 1-2 y until age 21-25 y; pubertal status and menarche data were collected.

238 is difference persisted regardless of sex or pubertal status at diagnosis.

239 mportant to use data obtained at the age and pubertal status being evaluated rather than to interpola

240 included demographic (sex, age, weight, and pubertal status), clinical, and family measures.

241 confounders [+5.1% L/min; country, sex, age, pubertal status, and BMI (adjusted P < 0.001) or fat mas

242 ect inclusion criteria, including mosaicism, pubertal status, and history of testosterone replacement

243 ree groups were matched for age, gender, and pubertal status, and obese children with NAFLD were matc

244 dy weight, which vary according to age, sex, pubertal status, and population ancestry in the pediatri

245 After adjustment for demographics, pubertal status, and psychiatric diagnosis, 1 hour less

246 race-ethnicity, socioeconomic status, Tanner pubertal status, percentage body fat, physical activity,

247 ifference by sex persisted after considering pubertal status.

248 rence persisted after further adjustment for pubertal status.

249 acebo) were adjusted for chronologic age and pubertal status.

250 examination and an assessment of growth and pubertal status.

251 girls, even after adjustment for height and pubertal status; boys with CF had higher body mass index

252 tion model was developed for prepubertal and pubertal subjects (Tanner stage </=4) aged >/=5 y.

253 a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for

254 eural systems modulating this behavior using pubertal Syrian hamsters (Mesocricetus auratus) as an ad

255 relevant blood levels of the drug, impaired pubertal testicular development until approximately 5 y

256 stage and become adult Leydig cells in post-pubertal testis.

257 Pubertal testosterone also decreased neuronal number in

258 la, suggesting a possible mechanism by which pubertal testosterone decreases volume in this subregion

259 The results show that pubertal testosterone has long-term organizational effec

260 In conclusion, pubertal testosterone organizes the medial amygdala in a

261 he medial amygdala such that the presence of pubertal testosterone resulted in 1) decreased volume of

262 in males that did not experience endogenous pubertal testosterone.

263 ogen/ERalpha-dependent cell proliferation in pubertal Tg (c-neu).

264 support higher absolute BMR/RMR and TDEE in pubertal than in prepubertal adolescents.

265 effects on IQ were significantly greater in pubertal than in prepubertal boys.

266 ation of BLL with IGF-1 was stronger for mid-pubertal than prepubertal boys (p = 0.04).

267 agonadal males before (juvenile) and after (pubertal) the pubertal resurgence of pulsatile GnRH rele

268 polychlorinated biphenyl concentrations with pubertal timing among Russian boys.

269 IR deleted in GnRH neurons displayed normal pubertal timing and fertility, but male and female mice

270 scribed inverse relationships between female pubertal timing and obesity.

271 nt advances regarding the genetic control of pubertal timing and presents areas for future investigat

272 egulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk r

273 try, physical activity by accelerometry, and pubertal timing by age at peak high velocity.

274 n between genetic variants and variations in pubertal timing has been discovered so far.

275 ovide insight into the mechanisms regulating pubertal timing in anabolic states.

276 ared, the relationship between body mass and pubertal timing in boys may be complex and requires furt

277 Early pubertal timing in girls is associated with psychosocial

278 increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasi

279 ciated with central or overall adiposity and pubertal timing in girls.

280 alling, among novel mechanisms that regulate pubertal timing in humans.

281 The effects of early pubertal timing on adolescent psychosocial problems were

282 Further, while many identified pubertal timing variants associate with age at menarche,

283 Pubertal timing was defined on the basis of self-reporte

284 bstitutes, infection rates, underweight, and pubertal timing) differ between these settings.

285 sity up to 14 years independent of sex, age, pubertal timing, and activity.

286 intelligence quotient, socioeconomic status, pubertal timing, and aerobic fitness (maximal oxygen vol

287 obesity, radiation-associated differences in pubertal timing, development of primary hypothyroidism,

288 Given the health impact of altered pubertal timing, further investigation across the life c

289 netic basis of pathological abnormalities in pubertal timing, including causes of idiopathic hypogona

290 of offspring outcomes, including changes in pubertal timing, intelligence quotient, and mental healt

291 ally active chemicals could plausibly affect pubertal timing, so we are investigating this in the Bre

292 ession in the liver, affecting body mass and pubertal timing.

293 ns of lipid-standardized concentrations with pubertal timing.

294 Many loci were associated with other pubertal traits in both sexes, and there was substantial

295 r 11 000 European samples with data on early pubertal traits, male genital and female breast developm

296 n associative region that matures during the pubertal transition and is implicated in decision making

297 Longitudinally, the age at pubertal transition was consistently older with greater

298 on variants in the coordinated timing of the pubertal transition.

299 ere the expression of Tacr3 increased across pubertal transition.

300 of height growth that was evident before the pubertal years.